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After the initial diagnostic laparoscopy the Study group patients undergo courses of polychemotherapy according to the scheme FLOT (the 1st, the 3rd, the 5th courses) and mFLOT (the 2nd , the 4th, the 6th courses) in the amount of 6 (six, 3+3); the examination is carried out every 3 courses (after the 3rd and the 6th c... |
<|newrecord|> nctId: NCT06313788 id: EC007-2324 briefTitle: Applying a Small Procedure Prior to Injection/Vaccination Reduces Pain Experiences in Child Patients overallStatus: NOT_YET_RECRUITING date: 2025-01-01 date: 2026-01-01 date: 2026-01-01 date: 2024-03-15 date: 2024-03-15 name: Lingnan University class: OTHER br... |
<|newrecord|> nctId: NCT06313775 id: SPS005 briefTitle: Comparison of Spinal Anesthesia and Spermatic Cord Block for Bilateral Orchiectomy overallStatus: ENROLLING_BY_INVITATION date: 2024-06-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-15 date: 2024-03-15 name: Sanpasitthiprasong Hospital class: OTHER_GOV briefS... |
• Is there a difference in the level of pain during bilateral orchiectomy between spinal anesthesia and spermatic cord block? |
Participants will undergo bilateral orchidectomy. They will be randomly assigned to two groups: the group receiving spinal anesthesia and the group receiving spermatic cord block If there is a comparison group: Researchers will compare intraoperative pain score, Morphine consumption during 6 and 12 hour after surgery, ... |
<|newrecord|> nctId: NCT06313762 id: Codi CEIm: 21/132-P briefTitle: Use of Virtual Reality in the Reduction of Pain After the Administration of Vaccines Among Children in Primary Care Centers. overallStatus: COMPLETED date: 2022-01-18 date: 2024-01-24 date: 2024-02-08 date: 2024-03-15 date: 2024-03-15 name: Fundacio d... |
The main question\[s\] it aims to answer are: |
1. To evaluate the reduction in pain during the administration of two vaccines in children aged 3 and 6 years. |
2. To evaluate the reduction in anxiety during and after the administration of two vaccines in children aged 3 and 6 years. |
3. Improve the satisfaction of parents or legal guardians after the administration of two vaccines in children aged 3 and 6 years. |
4. Evaluate the Safety of the use of virtual reality glasses in children aged 3 and 6 years during the administration of vaccines. |
The study population will include children aged 3 and 6 years who are included in the patient registry and are being seen in a primary care center of the Catalan Institute of Health in Central Catalonia. |
The clinical trial has two assigned groups: a control group and an intervention group. |
The intervention group will use the Pico G2 VR goggles (Pico Interactive Inc) during the administration of the two vaccines, together with an Android AOYODKG tablet, which will be connected to the goggles as a controller. |
The control group participants will receive traditional distractors, such as being held by the parent or guardian who accompanies them to the appointment, receiving stickers at the end of the appointment, or receiving rewards that the parent or guardian has prepared from home. |
International Registered Report Identifier (IRRID): PRR1-10.2196/35910 conditions: Pain conditions: Pediatrics conditions: Vaccination conditions: Virtual Reality studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The intervention group will use the Pic... |
The control group participants will receive traditional distractors, such as being held by the parent or guardian who accompanies them to the appointment, receiving stickers at the end of the appointment, or receiving rewards that the parent or guardian has prepared from home. primaryPurpose: HEALTH_SERVICES_RESEARCH m... |
<|newrecord|> nctId: NCT06313749 id: MMS-US-1 briefTitle: Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-12 date: 2025-12 date: 2024-03-... |
Eligible screened participants will undergo the MIMS® procedure and will be followed for a period of 12 months in this single-arm study. Investigators will compare the results of this study to the surgical success rate of traditional trabeculectomy with Mitomycin-C. conditions: Primary Open Angle Glaucoma conditions: O... |
<|newrecord|> nctId: NCT06313736 id: STU00220591_shortening id: 2T32MH115882-06A1 type: NIH link: https://reporter.nih.gov/quickSearch/2T32MH115882-06A1 briefTitle: What SSI Duration is Most Effective? An Online Experiment With American Adults overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-20 date: 2024-05 date: 20... |
In this online trial, participants will be randomized to a 15-minute single-session depression intervention called the Action Brings Change (ABC) Program, a 10-minute version of it, a 6-minute version of it, or a 2-minute version of it. The main analysis will evaluate how change in depressive symptoms over eight weeks ... |
<|newrecord|> nctId: NCT06313723 id: SBÜ-AYDINKARTAL-030 briefTitle: The Effect of Mother's Anxiety, Fear and Prenatal Connection in the Prenatal Education Given to Pregnant Women Via Podcast During the Non-stress Test overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-08-30 date: 2024-10-31 date: 2024-03-15... |
<|newrecord|> nctId: NCT06313710 id: Y (2024) 058 briefTitle: Head Down Position for Successful Recanalization of Anterior Circulation Large Vessel Occlusion (HOPES4) overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2026-12-01 date: 2026-12-01 date: 2024-03-15 date: 2024-04-19 name: General Hospital of Shenyang... |
<|newrecord|> nctId: NCT06313697 id: GR2102-001 briefTitle: A Study to Evaluate the Safety, Immunogenicity, and Pharmacokinetics of GR2102 in Healthy Adult overallStatus: NOT_YET_RECRUITING date: 2024-03-24 date: 2025-01-06 date: 2025-12-06 date: 2024-03-15 date: 2024-03-15 name: Genrix (Shanghai) Biopharmaceutical Co.... |
<|newrecord|> nctId: NCT06313684 id: Fondecyt 1230787 briefTitle: Comprehensive Hybrid Cardiac Rehabilitation Trial on Heart Failure acronym: COCREATIONHF overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-09 date: 2027-03 date: 2024-03-15 date: 2024-03-26 name: Universidad de La Frontera class: OTHER name: Uni... |
<|newrecord|> nctId: NCT06313671 id: Perfusion Index - FR study briefTitle: Plethysmographic Perfusion Index and Fluid Responsiveness acronym: PPI-FR overallStatus: RECRUITING date: 2024-02-10 date: 2024-09 date: 2024-09 date: 2024-03-15 date: 2024-03-15 name: Avicenna Military Hospital class: OTHER briefSummary: The o... |
<|newrecord|> nctId: NCT06313658 id: Total BPBI briefTitle: Enhancing Functional Hand Recovery Through Nerve Reconstruction in Total Brachial Plexus Birth Injury overallStatus: RECRUITING date: 2024-03-15 date: 2025-03-15 date: 2025-03-15 date: 2024-03-15 date: 2024-03-15 name: Assiut University class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06313645 id: B83C22004880006 briefTitle: Vascular Senescence and Atherosclerotic Plaque Vulnerability acronym: VICTORIA overallStatus: RECRUITING date: 2023-07-01 date: 2025-07-01 date: 2025-12-31 date: 2024-03-15 date: 2024-03-19 name: Niguarda Hospital class: OTHER name: Istituto di Fisiologia... |
It is increasingly evident that genomic instability activates signaling pathways that lead to a multitude of pathophysiological cellular and molecular changes. These changes promote inflammation, apoptosis, autophagy, and ultimately, cellular senescence, accompanied by the "senescence-associated secretory phenotype" (S... |
The objectives of the VICTORIA study are to examine the levels of aging-related non-coding RNA deregulation (specifically lncRNA TERRA and mitomiR) and peripheral markers of cell aging (including telomere length and mitochondrial DNA content) across the various spectra of angina pectoris (stable angina, unstable angina... |
<|newrecord|> nctId: NCT06313632 id: STUDY-23-01105 briefTitle: Erector Spinae Plane Block With Bupivacaine for Medical Thoracoscopy overallStatus: RECRUITING date: 2024-03-13 date: 2025-03 date: 2025-03 date: 2024-03-15 date: 2024-03-20 name: Icahn School of Medicine at Mount Sinai class: OTHER briefSummary: PlAcebo v... |
<|newrecord|> nctId: NCT06313619 id: BSMMU/20236831 briefTitle: Decreasing Irrational Antimicrobial Use in Bangladesh: A Digital Intervention Program overallStatus: RECRUITING date: 2023-10-23 date: 2024-03-31 date: 2024-03-31 date: 2024-03-15 date: 2024-03-15 name: Bangabandhu Sheikh Mujib Medical University, Dhaka, B... |
A before-after designed quasi experimental study will be conducted in urban areas. Data will be collected in both qualitative and quantitative methods. Multi-cluster sampling method will be used to select study locations. Pharmacists or drug sellers and patients aged more than 18 years and located within selected inter... |
The study is expected to bring light upon a comprehensive understanding of the current level of knowledge, perception and practice of irrational use of anti-microbials among target population. Furthermore, a digital intervention design will be produced to reduce irrational use of anti-microbials after considering its e... |
<|newrecord|> nctId: NCT06313606 id: 2047436 briefTitle: Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-05-31 date: 2024-05-31 date: 2024-03-15 date: 2024-03-26 name: University of California, Davis class: OTHER briefSummary: Long-chain cyc... |
<|newrecord|> nctId: NCT06313593 id: INCB160058-101 briefTitle: A Study to Evaluate the Safety, Tolerability of INCB160058 in Participants With Myeloproliferative Neoplasms overallStatus: NOT_YET_RECRUITING date: 2024-06-14 date: 2027-06-06 date: 2027-09-04 date: 2024-03-15 date: 2024-03-15 name: Incyte Corporation cla... |
<|newrecord|> nctId: NCT06313580 id: 22-1055 briefTitle: Spices for Cultivating a Healthy Gut Microbiome and Cardiometabolic Profile overallStatus: RECRUITING date: 2023-01-01 date: 2024-12 date: 2025-06 date: 2024-03-15 date: 2024-03-20 name: University of Alabama, Tuscaloosa class: OTHER name: McCormick Science Insti... |
<|newrecord|> nctId: NCT06313567 id: Meca-GC briefTitle: Metronomic Capecitabine in Stage III Gastric Cancer overallStatus: RECRUITING date: 2024-03-10 date: 2029-03-10 date: 2029-03-10 date: 2024-03-15 date: 2024-03-15 name: Fudan University class: OTHER briefSummary: The purpose of this study is to find out whether t... |
<|newrecord|> nctId: NCT06313554 id: HMPL-012-SH-ICC101 briefTitle: Surufatinib Combined With Toripalimab and HAIC in the Treatment of Inoperable or Metastatic Intrahepatic Cholangiocarcinoma overallStatus: NOT_YET_RECRUITING date: 2024-05-20 date: 2024-05-20 date: 2027-05-20 date: 2024-03-15 date: 2024-03-15 name: Fud... |
The study was divided into three stages: screening period, treatment period and follow-up period. During the treatment period, the tumor status was evaluated by imaging every 6 weeks (±7 days), and the efficacy was changed to every 8 weeks (±7 days) after 12 weeks until the disease progressed (RECIST 1.1) or death (dur... |
<|newrecord|> nctId: NCT06313541 id: 2024-Lung-LDRT/SBRT briefTitle: Treatment Response Adapted Hybrid Radiotherapy in Metastatic Non-small Cell Lung Cancer Receiving First-line Immunotherapy overallStatus: NOT_YET_RECRUITING date: 2024-03-10 date: 2025-06-30 date: 2025-12-31 date: 2024-03-15 date: 2024-03-15 name: Fud... |
<|newrecord|> nctId: NCT06313528 id: 18726 id: J1I-MC-GZBW type: OTHER domain: Eli Lilly and Company briefTitle: A Study to Measure Calorie Consumption and Usage in Participants With Obesity Using LY3437943 overallStatus: RECRUITING date: 2024-03-20 date: 2025-07 date: 2025-07 date: 2024-03-15 date: 2024-04-19 name: El... |
<|newrecord|> nctId: NCT06313515 id: STUDY00019529 briefTitle: Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI overallStatus: RECRUITING date: 2024-04-01 date: 2026-02-01 date: 2027-02-01 date: 2024-03-15 date: 2024-03-19 name: University of Washington class: OTHER brief... |
The main questions the study aims to answer are: |
* Conduct tSCS mapping to determine the most effective location and stimulation intensity for BP control in individuals with motor-complete SCI ≥ T6. |
* Evaluate the effects 8 weeks of targeted tSCS paired with arm-crank exercise compared to sham stimulation with exercise on improving cardiovascular function in individuals with motor-complete SCI ≥T6. |
* Evaluate the dosage-response of 8 weeks vs. 16 weeks of targeted tSCS paired with arm-crank exercise on cardiovascular function in individuals with motor-complete SCI ≥T6. |
* Explore the mechanisms involved in cardiovascular recovery with long-term tSCS paired with arm-crank exercise. |
Participants will: |
* Receive either transcutaneous spinal cord stimulation or "sham" spinal cord stimulation while exercising on an arm-crank bicycle in the first 8 weeks. |
* Come in for approximately 60 visits over a 6-month period. This includes 2, 8-week periods where the investigators will ask participants to come in 3x per week for spinal cord stimulation and exercise. |
* During assessment visits the researchers will perform a variety of exams including a neurologic, cardiovascular, pulmonary, physical, and autonomic exam, and will ask questions about quality of life and functioning. |
Researchers will compare those who receive tSCS and do moderate arm-crank exercise to those who receive a sham stimulation and do moderate arm-crank exercise to see if tSCS is effective at improving cardiovascular and autonomic functioning in those with SCI. conditions: Spinal Cord Injuries studyType: INTERVENTIONAL ph... |
<|newrecord|> nctId: NCT06313502 id: 274271 briefTitle: High Dose Ascorbic Acid (HDAA) in Patients With Plasma Cell Disorders overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2028-04 date: 2024-03-15 date: 2024-03-15 name: University of Arkansas class: OTHER name: University of Iowa briefSummary: The... |
Primary Objective To determine tumor response using International Myeloma Working Group (IMWG) criteria (see Appendix B). |
Secondary Objectives |
Objectives: |
1. Determine the safety and tolerability of HDAA in combination with reduced dose melphalan conditioning and autologous stem cell transplantation (ASCT) in relapsed refractory multiple myeloma subjects. |
2. Determine the rate of Minimal Residual Disease (MRD) negativity at time point of response assessment using 8 color flow cytometry on BM sample. Functional imaging, such as positron emission tomography (PET) scan and magnetic resonance imaging (MRI), will also be performed to assess the disease status. |
3. Categorize and quantify adverse events compared to historical control. |
4. Determine quality of life parameters using standardized health-related quality of life measures |
5. Determine oxidative stress parameters in plasma during treatment. conditions: Plasma Cell Disorder studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 18 type: ESTIMATED name: 75gm HDAA name: 100gm HDAA name: 125gm HDAA meas... |
<|newrecord|> nctId: NCT06313489 id: 282151 briefTitle: Rupture of Thumb's Long Extensor Tendon After Fracture of the Distal Radius, Study of Muscle and Tendon Pathology overallStatus: ACTIVE_NOT_RECRUITING date: 2023-02-01 date: 2023-12-31 date: 2024-06-30 date: 2024-03-15 date: 2024-03-15 name: Sahlgrenska University... |
There are different theories about the cause of the rupture. One theory is that the fracture creates a bleeding in the tight area that the tendon lies, leading to high pressure and therefore low blood supply to the tendon. Another theory is that the tendon comes in contact with some sharp bonny fragments in this area t... |
Such tendon ruptures need almost always some type of surgical intervention in order to reconstruct the function of the thumb. A common problem is that the quality of the tendon is insufficient for just suturing it. Another problem is that the muscle becomes stiff after the rupture. However, there is no objective method... |
The most common treatment option is the transfer of one of the two extensor tendons of the index finger to the thumb, a so-called extensor indicis proprius to extensor pollicis longus transfer. The motivation behind this operation is that the muscle of EPL is so stiff that cannot be used to lift the thumb. However, the... |
The study aims to investigate the microscopical changes in the muscle and tendon of EPL after such a rupture. Better knowledge of these factors could lead to better understanding of the treatment options. |
The investigators plan to include in the study all patients that would get operated for an EPL tendon rupture after a fracture of the distal radius at the institution the study is conducted. After oral and written information to the patient and written consent the investigators will take some samples from the ruptured ... |
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