text stringlengths 0 197k |
|---|
(a) Prevent development of CKD in the first place (b) Detect CKD earlier so that more cost-effective treatments can be given to slow progression. |
There is little evidence on factors that drive CKD progression in Malawi, or on interventions that may be cost-effective for improving detection and slowing disease progression in this setting. This PhD will address these knowledge gaps, through the following aims: |
1) Determine the mortality associated with CKD, and the risk factors driving its development and progression in Malawian adults 2) Investigate the impacts of different models for integrating screening and prevention strategies for CKD and its risk factors into health services for other long-term conditions in low- and ... |
<|newrecord|> nctId: NCT06312059 id: KNC-GMS-002 briefTitle: Goat or Cow Milk Based Infant Formula GMS overallStatus: RECRUITING date: 2023-12-14 date: 2024-08-15 date: 2024-08-15 date: 2024-03-15 date: 2024-03-15 name: Kendal Nutricare Ltd class: INDUSTRY name: ObvioHealth briefSummary: This study is a non-inferiority... |
<|newrecord|> nctId: NCT06312046 id: 2018 374-31 briefTitle: Motor-cognitive Performance in People With Multiple Sclerosis acronym: HiBalance-MS overallStatus: RECRUITING date: 2024-02-26 date: 2025-12-31 date: 2027-08-31 date: 2024-03-15 date: 2024-03-15 name: Karolinska Institutet class: OTHER name: Karolinska Univer... |
The investigators have adapted a previously developed balance training program to a highly challenging program specifically directed to MS (HiBalance-MS). This program was recently tested and found feasible in a pilot study. The investigators will now perform a randomized controlled trial in people with MS, in order to... |
<|newrecord|> nctId: NCT06312033 id: MRTG_P01 briefTitle: Estradiol's Effect on Brain Volume and Connectivity overallStatus: COMPLETED date: 2018-08-01 date: 2019-07-31 date: 2021-12-31 date: 2024-03-15 date: 2024-03-15 name: International Research Training Group 2804 class: OTHER name: University Hospital Tübingen nam... |
Parts of the study are already described in Rehbein et al., 2021 and 2022. conditions: Emotion Regulation conditions: Estradiol studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: The intervention assessed the effect of estradiol administration on stres... |
<|newrecord|> nctId: NCT06312020 id: HZNP-HZN-1116-201 briefTitle: A Phase 2 Study to Investigate Efficacy and Safety of HZN-1116 in Participants With Sjogren's Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2026-09-03 date: 2026-11-26 date: 2024-03-15 date: 2024-03-15 name: Horizon Therapeutics Irel... |
<|newrecord|> nctId: NCT06312007 id: UH23030202 briefTitle: Semi-seated Holding Position to Reduce Stress Responses in in the Neonatal Intensive Care Unit overallStatus: COMPLETED date: 2023-07-01 date: 2023-11-01 date: 2023-12-01 date: 2024-03-15 date: 2024-03-15 name: Hasanuddin University class: OTHER briefSummary: ... |
<|newrecord|> nctId: NCT06311994 id: GumushaneUni briefTitle: Applicability and Efficiency of Virtual Reality Intervention in Knee Surgery Patients overallStatus: RECRUITING date: 2024-02-01 date: 2024-05-01 date: 2025-04-01 date: 2024-03-15 date: 2024-03-15 name: Gümüşhane Universıty class: OTHER briefSummary: The str... |
<|newrecord|> nctId: NCT06311981 id: SPHIC-TR-THLC2023-08 briefTitle: Carbon Ion Radiotherapy for Locally Advanced Lung Cancer in Elderly Patients overallStatus: RECRUITING date: 2024-04-01 date: 2025-06-17 date: 2026-06-17 date: 2024-03-15 date: 2024-03-15 name: Jian Chen class: OTHER briefSummary: To observe the effe... |
<|newrecord|> nctId: NCT06311968 id: SPHIC-TR-THLC2023-07 briefTitle: The Clinical Study of Post-operative Proton Radiotherapy for Thymus Tumor overallStatus: RECRUITING date: 2024-04-01 date: 2027-02-28 date: 2027-02-28 date: 2024-03-15 date: 2024-03-15 name: Jian Chen class: OTHER briefSummary: To observe the efficac... |
<|newrecord|> nctId: NCT06311955 id: SPHIC-TR-THLC2023-06 briefTitle: Clinical Study of Postoperative Carbon Ion Radiotherapy for Thymus Tumor With Residual Tumor overallStatus: RECRUITING date: 2024-04-01 date: 2028-02-28 date: 2029-02-28 date: 2024-03-15 date: 2024-03-15 name: Jian Chen class: OTHER briefSummary: To ... |
<|newrecord|> nctId: NCT06311942 id: Precision AT-02 briefTitle: Triple vs. Dual Adjuvant Therapy Following Liver Resection for HCC. overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-12-31 date: 2028-12-31 date: 2024-03-15 date: 2024-03-15 name: Chen Xiaoping class: OTHER briefSummary: Vessels that encapsul... |
<|newrecord|> nctId: NCT06311929 id: Precision AT-01 briefTitle: Precision Adjuvant Therapy After Surgery for Hepatocellular Carcinoma overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-12-31 date: 2028-12-31 date: 2024-03-15 date: 2024-03-15 name: Chen Xiaoping class: OTHER briefSummary: Vessels that encaps... |
<|newrecord|> nctId: NCT06311916 id: Neoadj-Net briefTitle: Efficacy and Safety of Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning Model. overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-12-31 date: 2028-12-31 date: 2024-03-15 date: 2024-03-15 name: Chen Xiaoping ... |
<|newrecord|> nctId: NCT06311903 id: 36264PR430/11/23 briefTitle: Norepinephrine in Preperiod of Hypotensive Resuscitation in Hemorrhagic Shock overallStatus: RECRUITING date: 2023-12-01 date: 2024-04-01 date: 2024-04-01 date: 2024-03-15 date: 2024-03-15 name: Tanta University class: OTHER briefSummary: The aim of this... |
<|newrecord|> nctId: NCT06311890 id: 2023XLA141-2 briefTitle: Study to Evaluate the Efficacy, Safety and Tolerability of Photodynamic Therapy(PDT) With Chlorin-e6 in Treating Moderate to Severe Acne overallStatus: RECRUITING date: 2024-02-01 date: 2026-09-30 date: 2026-09-30 date: 2024-03-15 date: 2024-03-15 name: Xiyu... |
<|newrecord|> nctId: NCT06311877 id: 6795 briefTitle: Effects of Flavor Modification for Management of Radiation Induced Dysgeusia overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-02-14 date: 2025-02-14 date: 2024-03-15 date: 2024-03-15 name: University of South Florida class: OTHER briefSummary: Intervent... |
<|newrecord|> nctId: NCT06311864 id: PROxy240215 briefTitle: Real-World Observational Study on Patient-Reported Outcomes in the Treatment of Insomnia With Daridorexant in Canada overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-09-15 date: 2024-09-15 date: 2024-03-15 date: 2024-03-15 name: PeriPharm class: ... |
<|newrecord|> nctId: NCT06311851 id: PNCC140201 briefTitle: Transarterial Chemoembolization (TACE) Plus Bevacizumab for Liver Metastases overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-06-01 date: 2024-12-01 date: 2024-03-15 date: 2024-04-01 name: Pardis Noor Medical Imaging and Cancer Center class: OTHER... |
<|newrecord|> nctId: NCT06311838 id: 2023H0244 briefTitle: Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-12 date: 2029-12 date: 2024-03-15 date: 2024-04-09 name: Ohio State Universi... |
<|newrecord|> nctId: NCT06311825 id: IstanbulUCDH briefTitle: The Effect of Horticultural Therapy on Loneliness and Life Satisfaction in Elderly Adults Living in Nursing Home overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-07-31 date: 2024-10-31 date: 2024-03-15 date: 2024-03-15 name: Istanbul University ... |
In our country, no study has been found on the effects of horticultural therapy on physical or mental health in elderly individuals. This research will be conducted as a randomized control group study to examine the effects of horticultural therapy on loneliness and life satisfaction in elderly individuals living in nu... |
<|newrecord|> nctId: NCT06311812 id: CREC 2023.683 briefTitle: Retrospective Review on Uterovaginal Anomalies overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2025-02-14 date: 2025-02-14 date: 2024-03-15 date: 2024-03-15 name: Chinese University of Hong Kong class: OTHER briefSummary: Review of surgical outcome... |
<|newrecord|> nctId: NCT06311799 id: 2024-0102 briefTitle: Advancing Health Equity by Integrating Social-Clinical Models During Pregnancy acronym: FIMPreg overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2025-06-30 date: 2024-03-15 date: 2024-03-15 name: Geisinger Clinic class: OTHER name: Fami... |
<|newrecord|> nctId: NCT06311786 id: 257HV107 briefTitle: A Study to Look at How a Single Oral Dose of Carbon-14-Labelled [14C] BIIB091 Moves Through and is Processed by the Body in Healthy Male Participants acronym: Mass Balance overallStatus: NOT_YET_RECRUITING date: 2024-04-09 date: 2024-05-13 date: 2024-05-13 date:... |
<|newrecord|> nctId: NCT06311773 id: Protocol # 24-01 briefTitle: Pivotal Trial of the Boomerang Catheter for pDVA overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-01-15 date: 2029-01-15 date: 2024-03-15 date: 2024-03-15 name: Aveera Medical, Inc. class: INDUSTRY briefSummary: The purpose of this study is ... |
<|newrecord|> nctId: NCT06311760 id: D7700C00001 briefTitle: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of a Single Ascending Dose of AZD0292 In Healthy Participants overallStatus: RECRUITING date: 2024-04-09 date: 2024-09-24 date: 2024-09-24 date: 2024-03-15 date: 2024-04-18 name: AstraZeneca cla... |
<|newrecord|> nctId: NCT06311747 id: 24-1T/45 briefTitle: The Effect of Oculomotor Exercises in the Warm-up on Forehand and Backhand Stroke Performance in Tennis Players overallStatus: RECRUITING date: 2024-01-15 date: 2024-07 date: 2024-09 date: 2024-03-15 date: 2024-03-20 name: Ege University class: OTHER briefSummar... |
<|newrecord|> nctId: NCT06311734 id: LW231-I-01 briefTitle: A Study of LW231 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers and Participants With Chronic Hepatitis B Virus Infection overallStatus: ACTIVE_NOT_RECRUITING date: 2021-11-01 date: 2024-04-01 date: 2024-05-01 dat... |
<|newrecord|> nctId: NCT06311721 id: 20210033 id: 2023-508336-57 type: EUDRACT_NUMBER briefTitle: A Study to Compare ABP 234 and Keytruda® (Pembrolizumab) in Participants With Advanced or Metastatic Non-squamous Non-Small Cell Lung Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-19 date: 2027-10-22 date: 2027-10... |
<|newrecord|> nctId: NCT06311708 id: TN-401-0011 briefTitle: Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) acro... |
<|newrecord|> nctId: NCT06311695 id: IEO 960 briefTitle: Contrast-Enhanced Spectral Mammography (CESM) acronym: CESM overallStatus: ACTIVE_NOT_RECRUITING date: 2012-01-01 date: 2022-02-28 date: 2024-12-31 date: 2024-03-15 date: 2024-03-15 name: European Institute of Oncology class: OTHER briefSummary: The study's objec... |
<|newrecord|> nctId: NCT06311682 id: LP0162-1336 id: U1111-1285-6559 type: OTHER domain: World Health Organization (WHO) id: 2023-503630-44 type: OTHER domain: European Medicines Agency (EMA) briefTitle: A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children ... |
The study involves two different age groups: children aged 2 to under 12 years and infants aged 6 months to under 2 years. This trial compares tralokinumab +TCS to placebo + TCS for children with moderate-to-severe AD and evaluates tralokinumab + TCS for infants with moderate-to-severe AD. Infants will not receive plac... |
The children will be randomly assigned to receive tralokinumab + TCS or placebo + TCS for the initial 16 weeks, with the treatment being double-blinded. During the first 16 weeks, children will have a 2 out of 3 chance of getting tralokinumab and a 1 out of 3 chance of getting placebo. Thereafter, all subjects will rec... |
<|newrecord|> nctId: NCT06311669 id: 29409010104798 briefTitle: Comparative Study Between Isolated Iliac Vein Stenting Versus Concomitant Iliac Vein Stenting With Pelvic Vein Embolization in Patients With Pelvic Venous Insufficiency Secondary to Nonthrombotic Iliac Vein Lesions overallStatus: ACTIVE_NOT_RECRUITING date... |
<|newrecord|> nctId: NCT06311656 id: 18840 id: J5C-MC-FOAA type: OTHER domain: DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company briefTitle: A Study to Evaluate Safety, Tolerability of LY4100511 (DC-853) in Healthy Asian and Non-Asian Participants overallStatus: NOT_YET_RECRUITING date: 2024-03-12 d... |
<|newrecord|> nctId: NCT06311643 id: 35 briefTitle: Ameliorative Potential of Relaxing Back Massage on Puerperial Women's Hormones and Infant Weight overallStatus: COMPLETED date: 2023-03-02 date: 2023-09-01 date: 2024-03-01 date: 2024-03-15 date: 2024-03-15 name: Kafrelsheikh University class: OTHER briefSummary: Effe... |
<|newrecord|> nctId: NCT06311630 id: 65/23/IEC/JMMC&RI briefTitle: Comparative Study of Analgesic Effect of Ultrasound Guided PENG Block vs FEMORAL BLOCK in Hip Fracture overallStatus: RECRUITING date: 2023-05-20 date: 2025-01-20 date: 2025-03-20 date: 2024-03-15 date: 2024-03-15 name: Jubilee Mission Medical College a... |
<|newrecord|> nctId: NCT06311617 id: 231592 briefTitle: Retinal Vascular Changes During Pregnancy overallStatus: RECRUITING date: 2024-02-01 date: 2027-01 date: 2027-01 date: 2024-03-15 date: 2024-03-15 name: Vanderbilt University Medical Center class: OTHER briefSummary: The goal of this study is to better understand ... |
<|newrecord|> nctId: NCT06311604 id: 38RC22.0272 briefTitle: Evaluation of the Safety of Inhaled Sedation With Isoflurane in Head Trauma Patients acronym: IsoSAFE overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-12-01 date: 2024-03-15 date: 2024-03-15 name: University Hospital, Grenoble cl... |
Halogenated agents (Isoflurane, Sevoflurane) are a class of hypnotics routinely used in the operating room. However, doses used in surgical patients (\> 1 Minimal Alveolar Concentration, MAC) are not suitable in neuro-intensive care unit (ICU) patients at risk of intracranial hypertension because of the cerebral vasodi... |
The use of halogenated agents has been recently possible in the ICU through dedicated medical devices (Sedaconda ACD, Mirus). Recommended dosage are lower in the ICU, i.e. 0.3-0.7 MAC, because of their association with intravenous hypnotics and the absence of surgical stimuli. Several clinical studies in general ICUs s... |
The investigator hypothesise that 0.7 MAC Isoflurane can be administered in this population without deleterious effect on ICP. conditions: Traumatic Brain Injury studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective, open-label, single-centre, inte... |
<|newrecord|> nctId: NCT06311591 id: STUDY00000716 Part B id: 1P50MH129701 type: NIH link: https://reporter.nih.gov/quickSearch/1P50MH129701 briefTitle: Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part B acronym: Jaspr-PartB overallStatus: NOT_YET_RECRUITING date: 2024-04-01 dat... |
A Complementary Randomized Controlled Trial and Real-World Study for Efficacy, Effectiveness, and Implementation Study Design (CREID) will be used conditions: Suicidal Ideation conditions: Suicide Attempt conditions: Self Harm studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL... |
<|newrecord|> nctId: NCT06311578 id: 87704916LUC1001 id: 2023-506495-27-00 type: REGISTRY domain: EUCT number briefTitle: A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors overallStatus: RECRUITING date: 2024-04-10 date: 2028-11-08 date: 2033-11-30 date: 2024-03-15 date: 2024-04-25 na... |
<|newrecord|> nctId: NCT06311565 id: SBU-ISTANBUL-0001 briefTitle: Effects of Education After Colorectal Cancer Screening overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2024-10-30 date: 2024-12-30 date: 2024-03-15 date: 2024-03-15 name: Istanbul Saglik Bilimleri University class: OTHER briefSummary: The aim o... |
This study was planned to be conducted as a prospective randomized controlled study in a family health center in Istanbul. The universe of the research; The sample of individuals registered to the family health center will consist of a total of 70 individuals who meet the inclusion criteria for the study. |
Patient Diagnosis Form, Colorectal Cancer Screening Attitude Belief Scale, Healthy Lifestyle Behavior Scale II will be used to collect data. Data will be collected at the first encounter, 1 month later, 3 months later, pre-test and post-test. In the research, individuals will be divided into two groups: intervention (n... |
<|newrecord|> nctId: NCT06311552 id: 0856 briefTitle: Optimising CMR Scan Acquisitions for Novel Equipment/Sequences in Clinical Cardiovascular Populations. acronym: OPTMISE-HFpEF overallStatus: COMPLETED date: 2022-01-31 date: 2023-11-30 date: 2023-11-30 date: 2024-03-15 date: 2024-03-15 name: University of Leicester ... |
<|newrecord|> nctId: NCT06311539 id: IstanbulBUFC4 briefTitle: The Effect of Circadian Rhythm on Physical Performance in Healthy Male Individuals overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-08-01 date: 2024-10-01 date: 2024-03-15 date: 2024-03-15 name: Istanbul Bilgi University class: OTHER briefSumma... |
The aim of this study is to investigate to what extent strength training given at appropriate times for morning, evening and intermediate chronotypes creates changes in performance in healthy adult male individuals. conditions: Chronotype conditions: Exercise studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED ... |
<|newrecord|> nctId: NCT06311526 id: 24C303 briefTitle: Mechanism of Action of Focal Extracorporeal Shock Waves as a Treatment of Upper Limb Stroke Spasticity: a Pilot Study acronym: SASHA overallStatus: RECRUITING date: 2023-05-30 date: 2025-04-30 date: 2025-04-30 date: 2024-03-15 date: 2024-03-15 name: Istituto Auxol... |
There are different spasticity treatments, such as botulinum neurotoxin, in the first place. Among the emerging therapies is focal extracorporeal shock wave therapy, consisting of a sequence of sonic (mechanical) impulses with high peak pressure. |
Systematic reviews highlighted that shock waves effectively improve lower and upper limb spasticity. Moreover, the shock waves therapeutic effect can last up to 12 weeks from the last treatment session. |
When used to treat stroke spasticity, the shock waves' mechanism of action is poorly detailed. |
On the one side, shock waves could change the physical properties of the muscular tissue (e.g. viscosity, rigidity). |
On the other, the shock waves produce a robust mechanical stimulation that massively activates muscle and skin mechanoreceptors (e.g. muscle spindles). This activation would modulate, in turn, the spinal (and supra-spinal) circuits involved in spasticity. |
To our knowledge, no study investigated the shock waves mechanism of action in stroke upper limb spasticity. |
Research question: do shock waves exert their therapeutic effect on spasticity by changing the muscle's physical properties or by indirectly modulating the excitability of spinal circuits? |
Specific aims: To investigate the mechanism of action of shock wave therapy as a treatment of upper limb spasticity after a stroke. |
Two major hypotheses will be contrasted: shock waves reduce hypertonia 1) by changing the muscle's physical features or 2) by changing the motoneurons excitability and the excitability of the stretch reflex spinal circuits. |
Shock wave therapy is expected to improve spasticity, thus improving the following clinical tests: the Modified Ashworth Scale (an ordinal score of spasticity) and the Functional Assessment for Upper Limb (FAST-UL, an ordinal score of upper limb dexterity). |
This clinical improvement is expected to be associated with changes in spastic muscle echotexture assessed with ultrasounds, such as an improvement in the Heckmatt scale (an ordinal score of muscle echotexture in spasticity). |
Clinical improvement is also expected to be associated with an improvement in the following neurophysiological parameters: a reduction of the H/Mmax ratio (an index of hyperexcitability of the monosynaptic stretch reflex circuit), a decrease in amplitude of the F waves (a neurophysiological signal reflecting the excita... |
Understanding the shock wave mechanism of action will lead to a better clinical application of this spasticity treatment. |
If the shock waves exert their therapeutic effect by changing the muscle's physical properties, they could be more appropriate for patients with muscle fibrosis on ultrasounds. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.