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<|newrecord|> nctId: NCT06311110 id: #BC-11326 AM04 briefTitle: Impaired Toilet Training, LUTS and Bowel Dysfunction in Children With DCD overallStatus: ACTIVE_NOT_RECRUITING date: 2023-10-30 date: 2024-02-08 date: 2024-06-30 date: 2024-03-15 date: 2024-03-15 name: University Hospital, Ghent class: OTHER briefSummary: ... |
<|newrecord|> nctId: NCT06311097 id: M402 briefTitle: Dairy Products to Your Gut and Brain acronym: YourGutBrain overallStatus: RECRUITING date: 2024-04-08 date: 2025-09 date: 2025-09 date: 2024-03-15 date: 2024-04-15 name: University of Copenhagen class: OTHER name: University of Aarhus name: APC Microbiome Ireland br... |
In addition, a sub-study will be conducted to explore differences in gut and brain measures between women with daily (reference group) and few (intervention group) weekly bowel movements, respectively, and to explore associations between measures of gut- and brain function. conditions: Healthy conditions: Constipation ... |
The crossover intervention will include 60 participants. Another 40 participants will only complete the first (baseline) visit. primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: INVESTIGATOR count: 100 type: ESTIMATED name: Fermented dairy name: Non-fermented dairy measure: Difference in change from baseline in ... |
<|newrecord|> nctId: NCT06311084 id: 310211 briefTitle: IMAGINATOR 2.0: Co-design and Early Evaluation of a Novel Blended Digital Intervention Targeting Self-harm in Young People acronym: IMAG2 overallStatus: COMPLETED date: 2022-11-25 date: 2023-11-09 date: 2024-01-23 date: 2024-03-15 date: 2024-04-04 name: Imperial C... |
Following an initial proof-of-concept study of Imaginator (Di Simplicio et al., 2020), we co-designed a new version of the app that supports consolidation and practice of the techniques learnt in therapy, and adapted the protocol to be extended to younger adolescents. |
Imaginator 2.0 uses 'functional imagery training', training in individuals to develop and use functional (that is, helpful) mental images to support an alternative behaviour instead of self-harm. Mental imagery is the process of picturing something in the mind, and mental images have strong emotional and motivational c... |
<|newrecord|> nctId: NCT06311071 id: IR.SUMS.MED.REC.1401.200 briefTitle: The Predictive Value of Coronary Artery Calcium Score overallStatus: COMPLETED date: 2022-01-01 date: 2023-05-01 date: 2023-09-01 date: 2024-03-15 date: 2024-03-22 name: Shiraz University of Medical Sciences class: OTHER briefSummary: In this ana... |
<|newrecord|> nctId: NCT06311058 id: PRO00032531 briefTitle: Protein Supplementation After ACL Surgery overallStatus: RECRUITING date: 2024-02-16 date: 2026-12-01 date: 2027-12-01 date: 2024-03-15 date: 2024-04-02 name: The Methodist Hospital Research Institute class: OTHER briefSummary: The purpose of the study is to ... |
Secondary outcomes will be to evaluate the survey data from the KOOS JR and Tampa Scale surveys, as well as functional measures recorded during physical therapy. conditions: ACL Reconstruction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Subjects ... |
<|newrecord|> nctId: NCT06311045 id: 23-01469 briefTitle: Obstructive Sleep Apnea (OSA) and Sex-Specific Responses to N-acetylcysteine (NAC) overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-06 date: 2028-12 date: 2024-03-15 date: 2024-03-15 name: NYU Langone Health class: OTHER name: National Heart, Lung, and... |
<|newrecord|> nctId: NCT06311032 id: 22-01227 briefTitle: Clinician Decision Making Regarding Surveillance for Low-risk Intraductal Papillary Mucinous Neoplasms of The Pancreas overallStatus: COMPLETED date: 2023-03-29 date: 2023-06-28 date: 2023-07-28 date: 2024-03-15 date: 2024-03-15 name: NYU Langone Health class: O... |
<|newrecord|> nctId: NCT06311019 id: 791572 briefTitle: The Effects of CGM and Connected Pen in T2DM Treated With Multiple Daily Insulin Injections acronym: Dia2tech overallStatus: RECRUITING date: 2024-02-27 date: 2025-09-01 date: 2026-06-01 date: 2024-03-15 date: 2024-03-15 name: Klavs Würgler Hansen class: OTHER nam... |
<|newrecord|> nctId: NCT06311006 id: K170103J id: 2019-A02579-48 type: OTHER domain: ANSM briefTitle: Safety Registry of a Fecal Microbiota Transplant Cohort acronym: COSMIC-FMT overallStatus: RECRUITING date: 2021-01-04 date: 2029-01-04 date: 2029-01-04 date: 2024-03-15 date: 2024-03-15 name: Assistance Publique - Hôp... |
There is no cohort or multicenter registry in France prospectively collecting FMTs, the methods used, their efficacy and side effects. Likewise, there is no prospective collection focused on the cohort of stool donors. A large national cohort of patients who have undergone FMT as part of routine care as well as donors,... |
<|newrecord|> nctId: NCT06310993 id: STH22549 briefTitle: Exercise to Boost Immunity in Advanced Cancer acronym: BICEP overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2026-03-01 date: 2026-03-01 date: 2024-03-15 date: 2024-03-15 name: Sheffield Teaching Hospitals NHS Foundation Trust class: OTHER name: Univers... |
<|newrecord|> nctId: NCT06310980 id: SMARTPEN briefTitle: Pilot Study to Verify Effect of Smartpen Coordinated With Glucose Sensor. acronym: SMARTPEN overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-07-01 date: 2025-04-01 date: 2024-03-15 date: 2024-03-15 name: Giulio Frontino class: OTHER briefSummary: Th... |
Primary endpoint: time in range Secondary endpoints: other glucometrics, Hba1c, treatment satisfaction. conditions: Diabetes Mellitus, Type 1 studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 34 type: ESTIMATED name: smartpen measure: Time in ... |
<|newrecord|> nctId: NCT06310967 id: IG3018-23-02-01 briefTitle: A Dose Escalation Study of IG3018 in Subjects With Hyperuricemia With or Without Chronic Kidney Disease overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-06 date: 2025-06 date: 2024-03-15 date: 2024-03-15 name: Intelligem Therapeutics Australia P... |
Initiation Dose shall be at 0.25 g tablets (Cohort A) and doses are escalated to 0.5 g (Cohort B) and then to 1.0 g (Cohort C) in a planned manner. Each cohort will have 10 eligible patients. Randomization will be performed in Part 1 and as per the randomization code, 8 subjects will receive the active study drug (IG30... |
Part 2 is an open-label proof of concept study involving hyperuricemia subjects with advanced predialysis CKD (Stage 3A, Stage 3B and Stage 4), and treated with two doses \[0.5 g BID IG3018 (Cohort D) and 1.0 g BID IG3018 (Cohort E)\] . At least 5 to 8 hyperuricemia subjects with advanced CKD will be enrolled in each d... |
Part 2 is an open-label proof of concept study. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 46 type: ESTIMATED name: IG3018 name: Placebo matching IG3018 measure: Safety Assessments (Part 1 and Part 2) measure: The proportions of change from baseline in se... |
<|newrecord|> nctId: NCT06310954 id: 2022-KY-012 briefTitle: Ketogenic Diet in Pediatric Intractable Epilepsy overallStatus: RECRUITING date: 2022-08-11 date: 2024-04-30 date: 2024-04-30 date: 2024-03-15 date: 2024-03-15 name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University class: OTHER briefSummary: This study... |
<|newrecord|> nctId: NCT06310941 id: ABSENTA id: Pending type: OTHER domain: Ceim HCSC (ERB of Hospital Clinico San Carlos)) briefTitle: Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection acronym: ABSENTA overallStatus: NOT_YET_RECRUITING date: 2024-12-01 date... |
Lung infection is a serious complication that may occur during hospital stay and may need artificial respiration or even develop during artificial ventilation for other causes. |
Current specific treatment consists of intravenous antibiotics. The current study evaluated whether aspiration and drainage of infected sputum helps curing this severe complication and whether nebulized HS has additional benefits, like eradicating bacteria or reducing inflammation. conditions: Nosocomial Infection cond... |
<|newrecord|> nctId: NCT06310928 id: SBU-201001077-2022 briefTitle: The Effect of Thermal Blanket After Peripheral Artery Surgery overallStatus: RECRUITING date: 2022-05-20 date: 2024-03 date: 2024-03 date: 2024-03-15 date: 2024-03-15 name: Saglik Bilimleri Universitesi class: OTHER briefSummary: Peripheral arterial di... |
* To increase peripheral tissue perfusion and decrease neurovascular damage by using thermal blankets for heating after peripheral arterial surgery. |
* To reduce the degree of surgical wound site and ischemic pain by using thermal blankets for warming after peripheral arterial surgery. |
* To increase the patient's postoperative mobility and mobilization by using thermal blankets in peripheral artery postoperative warming. |
* To contribute to the control of pain, neurovascular follow-up and reduction of damage and mobilization, which are the main nursing goals after surgery. |
* To increase the comfort of the patient by utilizing the heat insulation and flexible effect of thermal blankets, thus providing an easy-to-apply, effective care in terms of nursing and increasing the quality of health care service. |
Research Design This study is a randomized controlled trial to determine the effect of a thermal blanket applied to the area after peripheral arterial surgery on the patient's circulation, pain and mobilization. conditions: Peripheral Arterial Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interven... |
<|newrecord|> nctId: NCT06310915 id: CROC202310 briefTitle: Oral Chemotherapeutic Drugs Were Analyzed in Patients With Driver Gene Negative Locally Advanced/Advanced Non-small Cell Lung Cancer With PS Score 2 A Prospective, Single-arm, Multicenter, Observational Study on the Efficacy and Safety of Radiochemotherapy Com... |
<|newrecord|> nctId: NCT06310902 id: 2024KY022 briefTitle: Single-cell Sequencing Analysis of Resectable/Borderline Resectable Pancreatic Cancer Patients overallStatus: RECRUITING date: 2024-03-01 date: 2026-03-01 date: 2026-09-01 date: 2024-03-15 date: 2024-03-15 name: Fujian Medical University Union Hospital class: O... |
<|newrecord|> nctId: NCT06310889 id: EPIC-Baseline-Survey briefTitle: Evaluation of Palliative Care Co-treatment by Attending Physicians and Nurses: an Online Survey as Part of the Project acronym: EPIC-BS overallStatus: WITHDRAWN date: 2024-04-01 date: 2024-06-30 date: 2024-06-30 date: 2024-03-15 date: 2024-03-18 name... |
<|newrecord|> nctId: NCT06310876 id: M24-852 briefTitle: A Thorough QT Study of ABBV-CLS-7262 in Healthy Subjects overallStatus: RECRUITING date: 2024-03-14 date: 2024-06 date: 2024-07 date: 2024-03-15 date: 2024-03-29 name: Calico Life Sciences LLC class: INDUSTRY name: AbbVie briefSummary: This is a randomized, blind... |
<|newrecord|> nctId: NCT06310863 id: EXOCOBIO-NASAL-01 briefTitle: Pivotal Study to Evaluate the Efficacy and Safety of Injection With LASBEAU Strong in Correction of Nasolabial Folds overallStatus: COMPLETED date: 2019-10-07 date: 2020-11-24 date: 2020-11-24 date: 2024-03-15 date: 2024-03-15 name: Asan Medical Center ... |
Aim: The aim of this study was to demonstrate the efficacy and safety of a new HA filler (LASBEAU Strong) (24 mg/mL) compared with a conventional HA filler (Restylane Lyft) for the restoration of nasolabial folds. |
Patients/methods: A total of 72 subjects were enrolled and randomized to receive injections of the new HA filler (test group) or the conventional HA filler (control group) on the left or right side of the face. The mean value difference in the Wrinkle Severity Rating Scale (WSRS) scores at week 24 evaluated primary eff... |
<|newrecord|> nctId: NCT06310850 id: KEAH-238 briefTitle: The Effect of Preprocedural Subanesthetic Ketamine on Pain and Anxiety overallStatus: COMPLETED date: 2013-06-01 date: 2023-01-01 date: 2023-06-01 date: 2024-03-15 date: 2024-03-15 name: Ankara Ataturk Sanatorium Training and Research Hospital class: OTHER_GOV b... |
<|newrecord|> nctId: NCT06310837 id: 2023KYPJ300 briefTitle: Effect of Immunosuppressants With Adalimumab Biosimilars vs Corticosteroids on Noninfectious Uveitis overallStatus: NOT_YET_RECRUITING date: 2024-03-27 date: 2024-08-27 date: 2025-06-30 date: 2024-03-15 date: 2024-03-15 name: Zhongshan Ophthalmic Center, Sun ... |
<|newrecord|> nctId: NCT06310824 id: MAB-22-101 briefTitle: Single Dose, Three-arm Study to Compare the Pharmacokinetic Similarity of MAB-22 Versus Prolia® overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-07 date: 2025-07 date: 2024-03-15 date: 2024-03-18 name: Xentria, Inc. class: INDUSTRY briefSummary: A Ra... |
<|newrecord|> nctId: NCT06310811 id: BHCT-RD06-04-01 briefTitle: Anti-CD19 CAR-T Cell Therapy in Participants With Moderate to Severe Active Systemic Lupus Erythematosus overallStatus: RECRUITING date: 2024-03-07 date: 2025-03-01 date: 2027-03-01 date: 2024-03-15 date: 2024-03-15 name: Wuhan Union Hospital, China class... |
This study will explore the safety of escalating doses of RD06-04 by presetting two dose levels (DL), with 3 to 6 patients enrolled in each dose level. After safety conclusions are reached in each group, the investigator can select the corresponding dose group to expand cases based on treatment response, but the total ... |
This study will enroll patients in a 3+3 design with two DLS: 1×105 CAR+T cells /kg for DL1 and 5×105 CAR+T cells /kg for DL2. |
Dose increment Refer to the 3+3 dose increment principle. Three subjects are expected to be enrolled in each dose group. |
1. Dose increment should start from the minimum dose, and it is not possible to conduct an incremental study of 2 or more dose groups at the same time. |
2. If 1 case of DLT occurs in each dose group, the dose level will be extended to 6 subjects. If 6 subjects at this dose level ≥2 subjects develop DLT, the dose level exceeds the MTD. The previous lower dose level will be extended to 6 subjects, and if 6 subjects have already been enrolled in the previous lower dose le... |
3. If DLT occurred in ≥2 subjects in the highest dose group, the researcher could select a dose between the high dose group and the medium dose group according to the specific situation and perform MTD evaluation. |
4. If the dose increase to the highest dose group still does not reach DLT, researchers can explore the safety and efficacy of higher doses according to specific circumstances. |
Case expansion: |
After the completion of DLT evaluation in all dose groups, the investigators could select the corresponding dose group of extended cases according to the treatment response, but the total number of cases should not exceed 12 (extended cases were not evaluated by DLT). conditions: Safety conditions: Effective studyType:... |
<|newrecord|> nctId: NCT06310798 id: Dnr. 2020-04603 briefTitle: Inter-organizational Health Planning for Older Adults: Public Dental Care and Municipal Care acronym: GAPA overallStatus: NOT_YET_RECRUITING date: 2025-03-01 date: 2025-05-15 date: 2026-03-01 date: 2024-03-15 date: 2024-03-15 name: Vastra Gotaland Region ... |
Following ethics approval, a study design was developed guided by the seven action-steps of the knowledge to action framework. In the sixth action-step, older adults within the existing dental care remuneration program in Sweden will serve as a base for the RCT. From there older adults,dental hygienists (DH) and nursin... |
<|newrecord|> nctId: NCT06310785 id: TJ-IRB20231191 briefTitle: Esketamine Anesthesia in Thoracic Surgery overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-08-31 date: 2024-08-31 date: 2024-03-15 date: 2024-03-15 name: Hui Xu class: OTHER briefSummary: Esketamine group was induced with esketamine 0.5 mg/kg,... |
<|newrecord|> nctId: NCT06310772 id: NSF 2304297 briefTitle: Assessing Comorbidities in Epilepsy Using Eye Movement Recordings acronym: ACER overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03-01 date: 2025-03-01 date: 2024-03-15 date: 2024-03-15 name: Eysz, Inc. class: INDUSTRY name: Wake Forest Universit... |
<|newrecord|> nctId: NCT06310759 id: R21088B briefTitle: Prospective Validation Study of High Volume Urine DNA Testing in Individuals With Suspicion of Urothelial Cancer acronym: UROSCOUT-1 overallStatus: RECRUITING date: 2024-01-08 date: 2026-12-31 date: 2029-12-31 date: 2024-03-15 date: 2024-03-15 name: Tampere Unive... |
<|newrecord|> nctId: NCT06310746 id: HLX6018-FIH101 briefTitle: A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Escalation Phase I Clinical Study to Assess the Safety, Pharmacokinetics, and Immunogenicity of HLX6018 in Healthy Subjects overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2025-12-30 date... |
This is a randomized, double-blind, placebo-controlled study with single dose escalation design to assess the safety, PK, and immunogenicity of HLX6018 in healthy subjects. It is planned to enroll 8-10 subjects in each of seven dose groups (0.25 mg/kg, 1.0 mg/kg, 4.0 mg/kg, 12 mg/kg, 25 mg/kg, 50 mg/kg, and 70 mg/kg). ... |
<|newrecord|> nctId: NCT06310733 id: REC 66-517-1-1 briefTitle: The Effects of Probiotics, Lactobacillus GG, in the Treatment of Abdominal Pain in Children With Functional Abdominal Pain Disorders overallStatus: RECRUITING date: 2024-03-21 date: 2025-12-31 date: 2026-02-20 date: 2024-03-15 date: 2024-03-18 name: Prince... |
Generally, the diagnosis of FAPDs is based on clinical symptoms and criteria, it can be divided into irritable bowel syndrome (IBS), abdominal migraine, functional abdominal pain (FAP) and functional dyspepsia (FD). Approximately 14% of children globally, between the ages of 4 and 18, experience functional abdominal pa... |
The pathogenesis of FAPDs is believed to result from disruptions in the microbiota-gut-brain axis, which may happen early in life or throughout. Hence, several studies, specifically in western countries, reported the role of probiotics, specifically Lactobacillus rhamnosus GG (LGG), in modulating abdominal symptoms in ... |
It is widely known that the diversity of gut microbiota depends on multiple factors including ethnicity, mode of delivery, dietary and environmental factors. However, the studies on the use of probiotics in pediatric patients with FAPDs have been mainly conducted in western countries. Since there are limited studies on... |
The secondary objectives are to measure daily pain score in children with and without FAPDs, to evaluate and compare the diversity of fecal microbiota in children with FAPDs and those without FAPDs, and to compare the diversity of fecal microbiota between children with FAPDs who took probiotics and those who did not. c... |
<|newrecord|> nctId: NCT06310720 id: 23-10026618 briefTitle: Postpartum Video Education in High Risk Populations overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-12 date: 2024-12 date: 2024-03-15 date: 2024-03-15 name: Weill Medical College of Cornell University class: OTHER briefSummary: This is a prospectiv... |
<|newrecord|> nctId: NCT06310707 id: EU RCT: ePatch vs 24h Holter id: 2022-A02338-35 type: OTHER domain: ANSM, French competent authority id: EA4/071/23 type: OTHER domain: German Ethics Committee_Charité Universitätsmedizin Berlin briefTitle: Arrhythmia Identification in Syncope Patients: ePatch® Versus 24h Holter ove... |
<|newrecord|> nctId: NCT06310694 id: EGE-HEM-SL-01 briefTitle: Additional Circular Dressing Material overallStatus: COMPLETED date: 2023-04-27 date: 2023-09-30 date: 2023-12-30 date: 2024-03-15 date: 2024-03-15 name: Ege University class: OTHER briefSummary: The study was conducted to determine the effect of fixing per... |
<|newrecord|> nctId: NCT06310681 id: ETH2223-2528 briefTitle: Pilot Testing of a Co-adapted Group Programme for Parents/Carers of Children With Complex Neurodisability acronym: ENCOMPASS overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-10 date: 2024-12 date: 2024-03-15 date: 2024-03-15 name: City, University ... |
The main questions it aims to answer are: |
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