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Concomitant use of sodium zirconium cyclosilicate (SZC) could allow a more liberal intake of fruit and vegetables for patients with CKD, as SZC effectively treats hyperkalemia and counteracts metabolic acidosis \[1\]. With this strategy, the beneficial effects of potassium in fruits and vegetables on (vascular) health ... |
Objective: To demonstrate that a potassium-rich diet, including the use of SZC as potential rescue treatment (in case of hyperkalemia), does not result in an unacceptable rise in plasma potassium (i.e. max rise of 0.5 mmol/L and no hyperkalemia). Study Design: Investigator initiated, single center, cross-over randomize... |
Intervention: Addition of fruit- and vegetables that contain 40 mmol of potassium on top of regular diet. Addition of SZC after 1 week in case hyperkaliemia develops (serum potassium \> 5,5 mmol/L). Weekly measurement of plasma potassium and dose adjustment of SZC if needed conditions: Hyperkalemia conditions: Diet ... |
<|newrecord|> nctId: NCT06365671 id: ASCT-CART briefTitle: CAR-T Following ASCT for Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (R/R B-NHL) With High-Risk Prognostic Factors overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2027-04 date: 2024-04-15 date: 2024-04-15 name: Ruijin Hospital class: O... |
<|newrecord|> nctId: NCT06365658 id: 2024/PTPiP/1 briefTitle: Cognitive Functioning in Adults With Somatic Diseases and General Population From a Biopsychosocial Perspective overallStatus: RECRUITING date: 2023-07-03 date: 2025-03 date: 2025-12 date: 2024-04-15 date: 2024-04-22 name: Bartosz M. Radtke class: OTHER_GOV ... |
The study group consist of minimal 600 adults (over 18 y.o.) who will be examined by qualified diagnosticians. Participants will be evaluated with tasks related to the studied variables: memory, learning and language. Furthermore informations regarding past and present health condition will be collected from participan... |
The main questions it aims to answer are: |
1. What is the profile of memory and learning among polish adults? |
2. Do gender and age moderates patterns of memory and learning functioning among polish adults? |
3. What is a specific pattern of language functioning in adults with neurologically recognized aphasic syndromes? |
4. Do gender moderates specific patterns of language functioning in adults with neurologically recognized aphasic syndromes? |
Researchers will compare the following groups of adults: |
1. general population/control group |
2. with neurologically recognized aphasic syndromes |
3. seniors (over 60 y.o.) conditions: Aphasia conditions: Development, Human conditions: Neuropathology studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 600 type: ESTIMATED name: Psychological assessment measure: Memory and learning measure: Language measure: Socio-demog... |
<|newrecord|> nctId: NCT06365645 id: 2138752 briefTitle: Feasibility & Acceptability of App-based Cognitive Behavioral Therapy for Postpartum Depression Prevention overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-12 date: 2024-04-15 date: 2024-04-15 name: Women and Infants Hospital of Rhode Isla... |
<|newrecord|> nctId: NCT06365632 id: OLTOSPAN-02 briefTitle: Clinical Study of the Effectiveness, Tolerability and Safety of the Drug "Anti-spike, Gel, 100 g in Bottles in Package No. 1" Produced by the Republican Unitary Enterprise "Unitekhprom BSU", With a Single Intraperitoneal Use After Surgery in Adult Patients Wi... |
<|newrecord|> nctId: NCT06365619 id: HCI168525 briefTitle: Neoadjuvant Ipilimumab/Nivolumab for Patients With Recurrent, High Risk, Resectable Melanoma acronym: NeoRelapse overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2026-08 date: 2029-08 date: 2024-04-15 date: 2024-04-15 name: University of Utah class: OTHER ... |
Participants will receive 2 cycles of treatment prior to their standard of care surgery. After surgery participants will receive standard of care adjuvant therapy and be followed for response. conditions: Melanoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TR... |
<|newrecord|> nctId: NCT06365606 id: CLS-015A briefTitle: Study to Evaluate Diagnostic Sensitivity and Specificity of iStatis Syphilis Ab Test at the Point- Of-Care Sites overallStatus: RECRUITING date: 2024-03-14 date: 2024-04-10 date: 2024-05-29 date: 2024-04-15 date: 2024-04-15 name: bioLytical Laboratories class: I... |
<|newrecord|> nctId: NCT06365593 id: D8450R00005 briefTitle: hATTR Polyneuropathy in Russia acronym: PRIMER overallStatus: RECRUITING date: 2023-12-29 date: 2024-05-31 date: 2024-05-31 date: 2024-04-15 date: 2024-04-15 name: AstraZeneca class: INDUSTRY briefSummary: A multicenter observational retrosPective Registry of... |
<|newrecord|> nctId: NCT06365580 id: Kylo-0603-I-C01 briefTitle: Dose Escalation Study of Kylo-0603 in Healthy Subjects overallStatus: RECRUITING date: 2023-05-23 date: 2024-06-30 date: 2024-06-30 date: 2024-04-15 date: 2024-04-16 name: Kylonova (Xiamen) Biopharma co., LTD. class: INDUSTRY briefSummary: This clinical t... |
<|newrecord|> nctId: NCT06365567 id: CE209/2023 briefTitle: Dietary Fructose: a Metabolic Switch in Pediatric Obesity-related Disease. acronym: EO2022 overallStatus: RECRUITING date: 2024-03-04 date: 2025-03-05 date: 2026-03-02 date: 2024-04-15 date: 2024-04-15 name: Azienda Ospedaliero Universitaria Maggiore della Car... |
Fructose is a monosaccharide naturally found in fruits, vegetables, and honey; due to its high sweetness and taste-enhancing properties, fructose is widely used in the food industry. High-fructose corn syrup, in particular, is one of the most widely used ingredients in the production of soft drinks, jams, breakfast cer... |
The objective of this study is to understand the effect of fructose on the molecular events that contribute to the evolution of the pediatric age, and its effective relationship with the onset of liver and osteoarticular complications in this population. Understanding the mechanisms of fructose regulation and its effec... |
<|newrecord|> nctId: NCT06365554 id: 2 briefTitle: On-Premise and Remote Robotic Neurointervention overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-01-01 date: 2025-06-01 date: 2024-04-15 date: 2024-04-15 name: Remedy Robotics, Inc. class: INDUSTRY name: Unity Health Toronto briefSummary: This study is a p... |
<|newrecord|> nctId: NCT06365541 id: GYLLPJ-2024006 briefTitle: The Efficacy and Safety of Dapagliflozin in Improving Heart Failure in Dialysis Patients overallStatus: RECRUITING date: 2024-03-01 date: 2024-08-31 date: 2024-08-31 date: 2024-04-15 date: 2024-04-15 name: The People's Hospital of Gaozhou class: OTHER brie... |
<|newrecord|> nctId: NCT06365528 id: 2023-0232 briefTitle: Tunneled Peripherally Inserted Central Catheter (PICC) in Adult Patients and Associated Outcomes overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2025-12-31 date: 2026-07-31 date: 2024-04-15 date: 2024-04-15 name: Hospital de Clinicas de Porto Alegre cl... |
<|newrecord|> nctId: NCT06365515 id: TUE010_IRTG_P5 briefTitle: Dopamine, Reward Learning and Sex Hormones overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-12 date: 2025-12 date: 2024-04-15 date: 2024-04-15 name: University Hospital Tuebingen class: OTHER name: German Research Foundation name: Uppsala Univers... |
To this end, dopamine intervention will be tested on effort-based decision-making and motivational circuits in three hormonal stages (i.e., women in early-follicular phase (EF), women in mid-luteal phase (ML), and men). Additionally, we are testing the effects of hormonal status on metabolic indices and its effects on ... |
The investigator hypothesizes that women in EF cycle phase (1) have naturally less dopamine and show less effort, and (2) they show greater improvement in effort-based decision-making after Levodopa administration. We have exploratory outcomes about (3) sex differences in reward-learning with and without Levodopa admin... |
<|newrecord|> nctId: NCT06365502 id: KY2023-156 briefTitle: Preventive Drug-coated Balloon Angioplasty in Vulnerable Atherosclerotic Plaque (RESTORE Trial) overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-12 date: 2030-12 date: 2024-04-15 date: 2024-04-15 name: Harbin Medical University class: OTHER name: Sha... |
<|newrecord|> nctId: NCT06365489 id: 113293 briefTitle: Comparison of Brachial Wrist Index Before and After Implantation of Arteriovenous Fistulas, Based on Brachial Artery overallStatus: ACTIVE_NOT_RECRUITING date: 2022-12-11 date: 2023-02-20 date: 2024-09 date: 2024-04-15 date: 2024-04-15 name: Golestan University of... |
<|newrecord|> nctId: NCT06365476 id: 202309126RIND briefTitle: FlexWave Trial: Efficacy of Extracorporeal Shock Wave Therapy in Post-Stroke Upper Limb Spasticity overallStatus: RECRUITING date: 2024-04-15 date: 2026-04-15 date: 2027-04-15 date: 2024-04-15 date: 2024-04-22 name: National Taiwan University Hospital class... |
<|newrecord|> nctId: NCT06365463 id: URIS202401 briefTitle: Telerehabilitation to Improve Balance and Mobility in Patients After Stroke acronym: TeleHome overallStatus: RECRUITING date: 2024-04-09 date: 2024-05-31 date: 2024-05-31 date: 2024-04-15 date: 2024-04-23 name: University Rehabilitation Institute, Republic of ... |
<|newrecord|> nctId: NCT06365450 id: IRB00315481 briefTitle: Breast and Cervical Cancer Education Program acronym: OCEAP overallStatus: COMPLETED date: 2022-09-22 date: 2024-02-28 date: 2024-04-05 date: 2024-04-15 date: 2024-04-15 name: Johns Hopkins University class: OTHER name: Older Women Embracing Life name: The Jo... |
<|newrecord|> nctId: NCT06365437 id: TCD601B101 briefTitle: A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation overallStatus: RECRUITING date: 2021-06-06 date: 2025-08 date: 2025-08 date: 2024-04-15 date: 2024-04-15 name: ITB-Med LLC class: INDUSTRY briefSummary: The purpose of this stud... |
<|newrecord|> nctId: NCT06365424 id: KY20151230-5-1 briefTitle: Fenofibrate in Patients With Primary Biliary Cholangitis (PBC) overallStatus: RECRUITING date: 2017-04-08 date: 2027-04 date: 2027-04 date: 2024-04-15 date: 2024-04-15 name: Xijing Hospital of Digestive Diseases class: OTHER briefSummary: An Open Label Lon... |
<|newrecord|> nctId: NCT06365411 id: GEM-KiT briefTitle: GEnomic Medicine in Kidney Transplantation Study acronym: GEM-KiT overallStatus: NOT_YET_RECRUITING date: 2024-06-03 date: 2030-01-01 date: 2035-01-01 date: 2024-04-15 date: 2024-04-24 name: Western Sydney Local Health District class: OTHER briefSummary: Investig... |
1. Determine non-HLA genomic mismatches between donor-recipient pairs which impact kidney allograft survival following transplantation |
2. Derive polygenic risk scores on pre-transplant blood and/or kidney biopsy samples which predict kidney allograft dysfunction |
3. Derive polygenic risk scores on post-transplant blood and/or kidney biopsy samples which predict kidney allograft dysfunction conditions: Transplant Complication conditions: Kidney Transplant Rejection studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: ... |
<|newrecord|> nctId: NCT06365398 id: SELECT id: XWHL-2018010 type: OTHER_GRANT domain: Xuanwu Hospital, Capital Medical University briefTitle: Safety and Efficacy of Low-dose hEparinization in Cerebral Angiography sTudy acronym: SELECT overallStatus: COMPLETED date: 2018-01-01 date: 2021-06-01 date: 2022-01-01 date: 20... |
Methods: A prospective, single-blind, randomized controlled study on patients who experienced transient ischemic attacks (TIAs) or acute ischemic strokes and underwent DSA is performed. Participants are randomized into three groups: regular-dose systemic heparinization, micro-dose systemic heparinization, and no hepari... |
<|newrecord|> nctId: NCT06365385 id: FOODSEQ-MARS briefTitle: Postprandial Metabolic and Appetite Responses to Different Food Intake Sequences in Athletes overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-09 date: 2024-10 date: 2024-04-15 date: 2024-04-15 name: Universidade do Porto class: OTHER name: Federaçã... |
However, to date, no studies on food intake sequence have targeted athletes, despite their increased CHO demands (Thomas et al., 2016) which could expose them to repeated episodes of hyperglycaemia and high glycaemic variability, known to increase the risk of adverse cardiovascular outcomes and all-cause mortality (Loa... |
Therefore, this randomised crossover trial is part of a wider project which seeks to explore the impact of food intake sequence on metabolic health and performance in athletes. Specifically, this trial aims to investigate the acute, postprandial metabolic and appetite responses to consuming an identical meal in two int... |
<|newrecord|> nctId: NCT06365372 id: MrgD and PAH briefTitle: Circulating MrgD in Pulmonary Hypertension overallStatus: RECRUITING date: 2024-04-10 date: 2024-05-10 date: 2024-06-01 date: 2024-04-15 date: 2024-04-15 name: Qilu Hospital of Shandong University class: OTHER briefSummary: The aim of the study is to observe... |
<|newrecord|> nctId: NCT06365359 id: 23_RIPH2-12 briefTitle: Systemic Lupus Erythematosus and Chlordecone Impregnation in Martinique acronym: LUNEK overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-10-15 date: 2025-11-15 date: 2024-04-15 date: 2024-04-15 name: University Hospital Center of Martinique class:... |
Epidemiological studies conducted in the French West Indies have shown that exposure to chlordecone at the levels observed is associated with an increased risk of developing several diseases, including premature birth and prostate cancer. Many of the adverse effects associated with chlordecone could be explained by its... |
Chlordecone has the potential to modify the activity of SLE through mechanisms other than its pro-estrogenic effects. In rats, chlordecone was observed to induce alterations such as a reduction in lymphocyte count, thymic atrophy, and a decrease in splenic germinal centers and NK cells. |
In a mouse model of systemic lupus erythematosus (SLE), exposure to chlordecone results in increased production of immune complexes and anti-DNA antibodies, which are markers of disease activity and monitoring. |
Chlordecone also has a cellular effect that reduces the apoptosis of potentially auto-reactive lymphocytes and stimulates the production of GM-CSF, IL-2, TNF-alpha, and IFN-gamma. The latter is central to the pathophysiology of SLE. While experimental studies suggest a potential impact of chlordecone on SLE, no human s... |
The most serious and feared complication of SLE is kidney damage. Kidney damage from the disease and the necessary immunosuppressive treatments can lead to significant morbidity and mortality, including death and end-stage chronic renal failure. Therefore, it is important to manage the disease carefully. Suspected lupu... |
The objective of this project is to determine whether there is a positive association between lupus nephritis occurrence in patients followed by the internal medicine department of the Martinique University Hospital and organochlorine pesticide chlordecone impregnation. conditions: Systemic Lupus Erythematosus conditio... |
<|newrecord|> nctId: NCT06365346 id: 2024.075-T briefTitle: Music Breathing Therapy for Children With Attention-deficit Hyperactivity Disorder and Their Caregivers overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-05-31 date: 2025-08-31 date: 2024-04-15 date: 2024-04-15 name: Chinese University of Hong Kong... |
<|newrecord|> nctId: NCT06365333 id: 1451_04/BVNTW-VNCSKTE briefTitle: Pneumatic Reduction For Intussusception In Children: A Retrospective Cohort Study overallStatus: COMPLETED date: 2016-01 date: 2017-12 date: 2024-04 date: 2024-04-15 date: 2024-04-15 name: National Children's Hospital, Vietnam class: OTHER name: Vin... |
<|newrecord|> nctId: NCT06365320 id: PROTEOMET briefTitle: Association Between Training Load and Lactate and Other Metabolites Analyzed by Metabolomic and Proteomic Techniques acronym: PROTEOMET overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-07 date: 2024-07 date: 2024-04-15 date: 2024-04-15 name: Fundació ... |
The application of omics analytical techniques such as proteomics and metabolomics in the field of sport allows us to understand how the human body responds to exercise and how sports results can be improved by optimising nutrition and training. Both omics techniques offer a quantitative measurement of the metabolic pr... |
Basketball is a high-intensity exercise modality interspersed with low-intensity. The performance requirements of basketball include aerobic and anaerobic metabolism, with anaerobic metabolism being considered the main energy system. Therefore, basketball players need great athletic ability to produce a successful perf... |
For optimal sports performance it is important to adjust the training load, i.e. the degree of effort that the player can withstand in a single training session. Coaches require effective and objective load monitoring tools that allow them to make decisions about training plans based on the needs of each player. |
Microsampling systems emerge as an alternative to venipuncture by facilitating self-sampling, which can be carried out outside healthcare centres, in a comfortable and precise way from a small finger prick that the user can perform. These systems are less expensive and can be effective in measuring the levels of glucos... |
<|newrecord|> nctId: NCT06365307 id: Histograft-SF-2023 briefTitle: Comparative Study of Gene-Activated Bone Substitute "Histograft" for Lumbar and Cervical Spinal Fusion overallStatus: RECRUITING date: 2023-11-13 date: 2024-04 date: 2025-04 date: 2024-04-15 date: 2024-04-15 name: Histograft Co., Ltd. class: INDUSTRY n... |
Distribution of treatment methods by groups: |
1A - use of "Histograft" for spinal fusion of the cervical spine, 50 patients |
1. B - use of synthetic osteoplastic material based on β-TCP for spinal fusion of the cervical spine, 50 patients |
2. A - use of "Histograft" for spinal fusion of the lumbar spine, 100 patients |
2B - use of bone autograft for spinal fusion of the lumbar spine, 100 patients primaryPurpose: TREATMENT masking: NONE count: 300 type: ESTIMATED name: Osteoplastic material based on octacalcium phosphate and biologically active nucleic acids for bone tissue regeneration Nucleostim-VEGF ("Histograft") name: Synthetic o... |
<|newrecord|> nctId: NCT06365294 id: REVET Study briefTitle: Rescue Extracranial Vertebral Stenting in Tandem Occlusions acronym: REVET overallStatus: RECRUITING date: 2020-12-31 date: 2024-04-30 date: 2024-05-31 date: 2024-04-15 date: 2024-04-16 name: Dr. Cuong Tran Chi class: OTHER briefSummary: The acute vertebrobas... |
<|newrecord|> nctId: NCT06365281 id: CARIES PREVALENCE briefTitle: Caries Prevalence, Experience and Risk Related Factors Among Early Middle-aged Patients Attending Cairo University overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-08 date: 2024-04-15 date: 2024-04-15 name: Cairo University class... |
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