text stringlengths 0 197k |
|---|
<|newrecord|> nctId: NCT06364878 id: 813533 briefTitle: Non-invasive Diagnostics of Microbial Keratitis overallStatus: RECRUITING date: 2023-08-23 date: 2025-03-01 date: 2028-04-08 date: 2024-04-15 date: 2024-04-15 name: Sorlandet Hospital HF class: OTHER_GOV briefSummary: Infectious keratitis is a significant cause of... |
This project is designed to break this cycle of nonspecific diagnosis, suboptimal treatment, and progressive worsening of vision with increased interventions. New, advanced diagnostics will be brought into the clinic to provide additional information which, if our hypothesis is correct, will result in more rapid and ac... |
Using in vivo confocal microscopy (IVCM) we will document the cellular status of the cornea and identify microbes infecting the cornea in real-time. Secondly, tear samples will be obtained from patients with keratitis to evaluate and quantify the molecular cytokine signatures associated with specific microbial species,... |
The project aims are translated into the following hypotheses: |
H1: In vivo confocal microscopy imaging features detect microbial keratitis consistent with clinical assessment and outcome at a greater frequency than microbiological culture results. |
H2: Cytokine profiles (or a subset of molecules) in the eye are specific for viral, bacterial, fungal, or amoebic keratitis; and H3: A combination of in vivo confocal microscopy and molecular profiling of the tear film can yield a specific keratitis diagnosis closely matching the clinical progression and outcome of ker... |
<|newrecord|> nctId: NCT06364865 id: 2022-04 briefTitle: AE05ML Device for ML Hem-o-lok Polymer Clip Delivery in Laparoscopic Surgical Procedures Observational Registery Study acronym: AE05ML overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2025-01-31 date: 2025-03-30 date: 2024-04-15 date: 2024-04-16 name: Tel... |
<|newrecord|> nctId: NCT06364852 id: LY007C1101 briefTitle: An Evaluation of LY007 Cell Injection for r/r B-NHL acronym: r/r B-NHL overallStatus: RECRUITING date: 2021-12-25 date: 2024-08-31 date: 2026-05-31 date: 2024-04-15 date: 2024-04-15 name: Ruijin Hospital class: OTHER name: The First Affiliated Hospital with Na... |
<|newrecord|> nctId: NCT06364839 id: CT2024-ZJU-OBS7 briefTitle: Liver Transplantation for Hepatocellular Carcinoma Arising in Non-cirrhotic Liver: a Propensity Score-matched Retrospective Cohort Study of Two National Databases overallStatus: COMPLETED date: 2024-02-20 date: 2024-03-23 date: 2024-03-25 date: 2024-04-15... |
Methods: This retrospective study analyze outcomes between adult HCC recipients arising in non-cirrhotic and cirrhotic liver from two national databases (CLTR and UNOS, January 2015 to December 2020). Based on important variables, 1:2 and 1:1 propensity score matching (PSM) were performed respectively. conditions: Hepa... |
<|newrecord|> nctId: NCT06364826 id: NPC-202403 briefTitle: Sintilimab Combination Therapy Plus IMRT in Nasopharyngeal Carcinoma overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2026-04-22 date: 2026-04-22 date: 2024-04-15 date: 2024-04-15 name: Zhejiang Cancer Hospital class: OTHER briefSummary: This is a pros... |
<|newrecord|> nctId: NCT06364813 id: H20-01461 briefTitle: Co-developing a Novel Intervention to Promote Wellbeing of Family Caregivers of Individuals With Spinal Cord Injury overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-11 date: 2024-04-15 date: 2024-04-23 name: University of British Columbi... |
<|newrecord|> nctId: NCT06364800 id: GDT-001-07-02 briefTitle: Allogeneic Gamma-delta T Cells Combined With Targeted Therapy and Immunotherapy in a Phase 1 Clinical Trial of Hepatocellular Carcinoma Resistant to PD-1 Monoclonal Antibody overallStatus: NOT_YET_RECRUITING date: 2024-04-26 date: 2026-04-26 date: 2026-09-2... |
Hepatocellular Carcinoma conditions: Hepatocellular Carcinoma studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 18 type: ESTIMATED name: γδ T cells name: PD-1 monoclonal antibody name: targeted drugs measure: Safety evaluatio... |
<|newrecord|> nctId: NCT06364787 id: GDT-001-07-01 briefTitle: Allogeneic Gamma-delta T Cells Combined With Targeted Therapy and Immunotherapy in a Phase 1 Clinical Trial for First-line Treatment of Hepatocellular Carcinoma overallStatus: NOT_YET_RECRUITING date: 2024-04-26 date: 2026-04-26 date: 2026-09-26 date: 2024-... |
<|newrecord|> nctId: NCT06364774 id: 22-020309 briefTitle: ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-12-31 date: 2027-12-31 date: 2024-04-15 date: 2024-04-15 name: Children's Hospital of Philadelphia class: OTHER briefSummary: The main goal of t... |
<|newrecord|> nctId: NCT06364761 id: 24103_BIL_EDOF briefTitle: Assesment of Intermediate Vision After BIL Cataract Surgery overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2024-12 date: 2024-04-15 date: 2024-04-15 name: Universitair Ziekenhuis Brussel class: OTHER briefSummary: The goal of this obse... |
The main question it aims to answer is whether patiens who underwent this type of cataract surgery have better intermediate vision without spectacle correction than patients who underwent the classic lens in the bag cataract surgery. |
Participants will: |
* Have to read with and without spectacle correction at different distances (4 meters, 66 centimeters, 40 centimeters) |
* Have to fill in 2 questionnaires about visual functioning and spectacle independance |
Researchers will compare these values to the same values from the standard population who underwent the classic lens in the bag cataract surgery with a monofocal intraocular lens . conditions: Cataract studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 38 type: ESTIMATED name... |
<|newrecord|> nctId: NCT06364748 id: 002-2024-Shalowitz briefTitle: Expanding Access to Care Through Telemedical Support for Vital Sign Monitoring in High-risk Patients With Cancer overallStatus: RECRUITING date: 2024-03-11 date: 2025-03 date: 2025-09 date: 2024-04-15 date: 2024-04-15 name: West Michigan Cancer Center ... |
<|newrecord|> nctId: NCT06364735 id: Entità e variabili briefTitle: Entities and Variables Related to Catch-up Growth overallStatus: RECRUITING date: 2024-05-01 date: 2024-11-01 date: 2024-12-01 date: 2024-04-15 date: 2024-04-29 name: ASST Fatebenefratelli Sacco class: OTHER briefSummary: A retrospective monocentric ob... |
<|newrecord|> nctId: NCT06364722 id: ZYS2024-02 briefTitle: Effect of Acupuncture on the Microbiota-gut-brain Axis in Crohn's Disease overallStatus: COMPLETED date: 2015-05-01 date: 2023-12-31 date: 2024-03-28 date: 2024-04-15 date: 2024-04-15 name: Shanghai Institute of Acupuncture, Moxibustion and Meridian class: OTH... |
<|newrecord|> nctId: NCT06364709 id: 4526 id: R01DC015516 type: NIH link: https://reporter.nih.gov/quickSearch/R01DC015516 briefTitle: Criterion-learning Based Naming Treatment in Aphasia overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2028-08 date: 2028-08 date: 2024-04-15 date: 2024-04-15 name: Albert Einste... |
<|newrecord|> nctId: NCT06364696 id: 4396-CL-0101 briefTitle: A Study to Find a Suitable Dose of ASP4396 in Adults With Solid Tumors overallStatus: RECRUITING date: 2024-04-16 date: 2027-04-30 date: 2027-04-30 date: 2024-04-15 date: 2024-04-29 name: Astellas Pharma Inc class: INDUSTRY briefSummary: Genes contain geneti... |
ASP4396 is being developed as a potential new treatment for solid tumors in people who have the G12D mutation in their KRAS gene. ASP4396 is not currently available as a treatment for the public. In this study, researchers will learn how ASP4396 is processed by and acts upon the body. This information will help find a ... |
In this study, ASP4396 is being given to humans for the first time. |
People in this study will be adults with locally advanced (unresectable), or metastatic solid tumors with the G12D mutation in their KRAS gene. Locally advanced means the cancer has spread to nearby tissue. Unresectable means the cancer cannot be removed by surgery. Metastatic means the cancer has spread to other parts... |
The main aims of the study are to check the safety of ASP4396, how well people cope with medical problems during the study (how well it is tolerated), and to find a suitable dose of ASP4396. |
This is an open-label study. This means that people in this study and clinic staff will know that they will receive ASP4396. |
This study will be in 2 parts. |
Part 1 is called Dose Escalation. Different small groups of people will receive lower to higher doses of ASP4396. For each dose, all medical problems will be recorded. The first group will receive the lowest dose of ASP4396. A medical expert panel will check the results and decide if the next group can receive a higher... |
Part 2 is called Dose Expansion. Other different small groups of people will receive ASP4396 with the most suitable doses worked out from Part 1. This will help find a more accurate dose of ASP4396 to use in future studies. |
In both parts of the study, ASP4396 will be given through a vein. This is called an infusion. Each treatment cycle is 21 days long. People will continue treatment until: they have medical problems from the treatment they can't cope with (can't tolerate); their cancer gets worse; they start other cancer treatment; or th... |
People will visit the clinic on certain days during their treatment, with extra visits during the first 2 cycles of treatment. The study doctors will check for any medical problems from ASP4396. Also, people in the study will have a health check including blood tests. On some visits they will also have scans to check f... |
People will visit the clinic about 7 days after they stop treatment. They will be asked about any medical problems and will have a health check including blood tests. |
After this, people will visit the clinic for a health check several times. The number of visits and checks done at each visit will depend on the health of each person and whether they completed their treatment or not. |
After treatment has finished, people in the study will be followed up for up to 45 weeks. conditions: Solid Tumor studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 175 type: ESTIMATED name: ASP4396 measure: Incidence of Dose ... |
<|newrecord|> nctId: NCT06364683 id: AIBU-HSF-SDEMIR-04 briefTitle: Coronary Artery Disease and Exercise Adherence overallStatus: NOT_YET_RECRUITING date: 2024-05-13 date: 2024-11-13 date: 2025-05-13 date: 2024-04-15 date: 2024-04-15 name: Abant Izzet Baysal University class: OTHER briefSummary: This study aims to dete... |
<|newrecord|> nctId: NCT06364670 id: ZSLL-KY-2023-011-01 briefTitle: Application of Machine Learning Based on fNIRS in Predicting Acupuncture's Efficacy in Treating Tinnitus overallStatus: RECRUITING date: 2024-05 date: 2026-08-31 date: 2026-12-31 date: 2024-04-15 date: 2024-04-15 name: The Third Affiliated hospital of... |
<|newrecord|> nctId: NCT06364657 id: IRB00439625 briefTitle: Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry Eye acronym: IIR overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-07-31 date: 2027-07-31 date: 2024-04-15 date: 2024-04-15 name: Johns Hopkins University... |
1. To determine whether dry eye is associated with reduced corneal sensation |
2. To determine whether reduced corneal sensation is due to the severity of the dry eye, the type of dry eye (primarily aqueous deficient versus primarily evaporative) or entirely related to the presence of Sjogren's |
3. To determine whether corneal sensation is associated with ocular or systemic pain symptoms Additionally, the study aims to compare the novel corneal esthesiometer measurements to confocal biomicroscopy findings in determining neurotrophic keratitis (NK) and assess correlations between corneal sensation. conditions: ... |
<|newrecord|> nctId: NCT06364644 id: IRB00336599 id: 1P50MD017348-01 type: NIH link: https://reporter.nih.gov/quickSearch/1P50MD017348-01 briefTitle: Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure acronym: UNLOAD-HF overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 202... |
<|newrecord|> nctId: NCT06364631 id: 2023-503317-29-00 id: 2023/3764 type: OTHER domain: CSET number briefTitle: CARE1 Pragmatic Clinical Trial acronym: CARE1 overallStatus: RECRUITING date: 2024-04-12 date: 2032-05-05 date: 2032-05-05 date: 2024-04-15 date: 2024-04-19 name: Gustave Roussy, Cancer Campus, Grand Paris c... |
Study design has been developed to demonstrate that ICI-ICI is superior to ICI-VEGFR TKI in prolonging Overall Survival (OS) for PDL1(+) patients and to demonstrate that ICI-VEGFR TKI is superior to ICI-ICI in prolonging Progression Free Survival (PFS) and OS for PDL1(-) patients. conditions: Metastatic Kidney Cancer c... |
<|newrecord|> nctId: NCT06364618 id: G-24-07 briefTitle: Use of Wearables to Detect Infections in Kidney Transplant Recipients acronym: RENALERT overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2026-12-31 date: 2027-12 date: 2024-04-15 date: 2024-04-15 name: Institute for Clinical and Experimental Medicine clas... |
The main questions it aims to answer are: |
1. What are the biometric data pattern changes in impending infections? |
2. What accuracy the machine learning algorithm can achieve? |
Participants will be given/use their own wearable device that will record biometric data. Any infection event will be recorded and an algorithm will be trained to recognize changes in biometric data preceding symptomatic infection. conditions: Kidney Transplant Infection studyType: OBSERVATIONAL observationalModel: COH... |
<|newrecord|> nctId: NCT06364605 id: IIT_UVIP_MySpace briefTitle: MySpace: the Role of Vision in Representing Space overallStatus: ENROLLING_BY_INVITATION date: 2021-05-03 date: 2021-06-26 date: 2025-12-31 date: 2024-04-15 date: 2024-04-15 name: Istituto Italiano di Tecnologia class: OTHER briefSummary: My Space aims t... |
<|newrecord|> nctId: NCT06364592 id: 2024-011-KY briefTitle: Electroacupuncture for Dysmenorrhea Secondary to Adenomyosis overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-02 date: 2026-05 date: 2024-04-15 date: 2024-04-15 name: Guang'anmen Hospital of China Academy of Chinese Medical Sciences class: OTHER bri... |
<|newrecord|> nctId: NCT06364579 id: 6533 briefTitle: Patient Reported Outcomes (PROs) in Anal Cancer Patient Treated by Intensity Modulated Radiotherapy (IMRT). acronym: PROACT overallStatus: RECRUITING date: 2024-03-28 date: 2027-01-31 date: 2031-01-31 date: 2024-04-15 date: 2024-04-15 name: Fondazione Policlinico Un... |
<|newrecord|> nctId: NCT06364566 id: time-exploring briefTitle: Exploring the Optimal Timing of Minimally Invasive Surgery for Esophageal Squamous Cell Carcinoma overallStatus: COMPLETED date: 2010-10-15 date: 2016-10-15 date: 2019-10-15 date: 2024-04-15 date: 2024-04-15 name: Shanghai Zhongshan Hospital class: OTHER b... |
<|newrecord|> nctId: NCT06364553 id: NL86416.078.24 briefTitle: Esophageal Self-expandable Metal Stent for Malignant Strictures: a Safety and Efficacy Study acronym: ENTRANCE overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-05-01 date: 2024-04-15 date: 2024-04-15 name: Erasmus Medical Cent... |
<|newrecord|> nctId: NCT06364540 id: 2023-08-14 briefTitle: Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the ED acronym: KETAFEN overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-06-30 date: 2026-12-31 date: 2024-04-15 date: 2024-04-15 name: Antonios Likourezos class: OT... |
Our research team has published two case series of 10 adult patients who were given nebulized ketamine (via BAN) for a variety of acute traumatic and non-traumatic painful conditions. The patients showed a 60% decrease in pain and a small number of side effects. Furthermore, our group published a randomized, double-bli... |
Nebulized fentanyl given in the ED to adults with acute traumatic and non-traumatic pain syndromes at a dose range of 1.5-4 mcg/kg showed the same or even better pain-relieving effects than IV fentanyl and IV morphine alone. |
Our objective is to compare the analgesic efficacy and rates of side effects of a 0.75 mg/kg dose of ketamine administered via breath-actuated nebulizer (BAN) to a dose of 3 mcg/kg of fentanyl administered via breath-actuated nebulizer (BAN) in adult patients presenting to the ED with acute painful conditions. conditio... |
<|newrecord|> nctId: NCT06364527 id: ADH-BSA-02-23 briefTitle: Use of Aptar Digital Health's Respiratory Disease Management Platform for Asthma overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-11 date: 2024-04-15 date: 2024-04-15 name: CoheroHealth class: INDUSTRY name: Aptar Digital Health name... |
The Aptar Digital Health respiratory disease management platform, a digital therapeutic will be utilized to determine its value and how it supports: i) asthma patient engagement and facilitates communication between patients and providers to accelerate medication adherence; ii) asthma control through the use of the Ast... |
<|newrecord|> nctId: NCT06364514 id: IRB-P00047313 briefTitle: PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-07-01 date: 2025-10-01 date: 2024-04-15 date: 2024-04-15 name: Boston Children's Hospital class: OTHER brief... |
<|newrecord|> nctId: NCT06364501 id: KH801 briefTitle: Phase 1 Trial of KH801 overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-01 date: 2030-05-01 date: 2024-04-15 date: 2024-04-17 name: Beijing Kanghong Biopharmaceutical Co., Ltd. class: INDUSTRY briefSummary: KH801 is a injection used for advanced sol... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.