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* complete three separate assessments three months after completing the treatment - a clinical interview to evaluate symptoms, a cognitive assessment, and completing a set of questionnaires conditions: Post-Traumatic Stress Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL... |
One group will receive nine sessions of Trauma-Informed Goal Management Training, and the other group will receive nine sessions of standard Goal Management Training. |
Each group session will be 2 hours long, and offered virtually (using Zoom for Healthcare). primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 64 type: ESTIMATED name: Trauma-Informed Goal Management Training (TI-GMT) name: Goal Management Training (GMT) measure: Change... |
<|newrecord|> nctId: NCT06354348 id: GastrectomyUSG briefTitle: Practical Ultrasonographic Detection of Sarcopenia in Patients With Long-term Gastrectomy overallStatus: COMPLETED date: 2023-12-06 date: 2024-03-30 date: 2024-03-30 date: 2024-04-09 date: 2024-04-09 name: Dr Abdurrahman Yurtaslan Ankara Oncology Training ... |
<|newrecord|> nctId: NCT06354335 id: 1-16-02-62-20 briefTitle: Impact of a Major Organizational Change on Employee Productivity and Mental Health acronym: PRO-MENTA overallStatus: ACTIVE_NOT_RECRUITING date: 2022-03-01 date: 2024-12-31 date: 2026-12-31 date: 2024-04-09 date: 2024-04-11 name: Aarhus University Hospital ... |
<|newrecord|> nctId: NCT06354322 id: APHP230630 briefTitle: Unclassified GENotypes of Autoinflammatory Diseases and AA Amyloidosis acronym: IPHYGENI MAI overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-06 date: 2034-05 date: 2024-04-09 date: 2024-04-09 name: Assistance Publique - Hôpitaux de Paris class: OTHE... |
However, genetic analyses are sometimes confronted with results that are difficult to interpret. These are the Variants of Unknown Significance, for which genetic analysis alone does not allow to determine if the genetic mutation is responsible for the symptoms. |
genetic analysis sometimes has limitations in the diagnosis of AID which can only be overcome by pathophysiological studies of the variants found. conditions: AA Amyloidosis conditions: Autoinflammatory Disease studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 200 type: ESTIM... |
<|newrecord|> nctId: NCT06354309 id: vr_study briefTitle: The Impact of Immersive Virtual Reality Training on Adult: Motion Sickness, and Ocular Surface: A Pilot Study overallStatus: COMPLETED date: 2023-08-01 date: 2023-10-20 date: 2023-10-20 date: 2024-04-09 date: 2024-04-09 name: He Eye Hospital class: OTHER briefSu... |
<|newrecord|> nctId: NCT06354296 id: CAF2024 briefTitle: Comparison of the Accuracy of Different Intraocular Lens Power Calculation Formulas in Cataract Patients With Prior Radial Keratotomy overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-08-15 date: 2024-08-31 date: 2024-04-09 date: 2024-04-09 name: He E... |
<|newrecord|> nctId: NCT06354283 id: Progresif briefTitle: Progressive Muscle Relaxation Exercises Women With Low Sexual Satisfaction Sexual Satisfaction and Functioning of Women and Their Partners overallStatus: COMPLETED date: 2023-04-10 date: 2024-01-30 date: 2024-02-08 date: 2024-04-09 date: 2024-04-09 name: Halic ... |
Method: The single-blind, randomized controlled study was conducted between April 2023 and January 2024. The sample of the study was women with low sexual satisfaction and their partners were randomized into two groups as intervention and control. Each group consisted of 120 couples, n=60. The women in the intervention... |
<|newrecord|> nctId: NCT06354270 id: 300104 briefTitle: A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers overallStatus: ACTIVE_NOT_RECRUITING date: 2024-04-11 date: 2024-06-24 date: 2024-06-24 date: 2024-04-09 date: 2024-04... |
<|newrecord|> nctId: NCT06354257 id: 220104 briefTitle: A Study to Investigate the Pharmacokinetics of a Combined Oral Contraceptive When Given Alone and in Combination With GSK3036656 in Female Participants of Non-childbearing Potential Aged 18 to 65 Years of Age overallStatus: NOT_YET_RECRUITING date: 2024-04-05 date... |
<|newrecord|> nctId: NCT06354244 id: 2023-183-KY-02 briefTitle: Electroacupuncture of Different Treatment Frequency in Chronic Urinary Retention Caused by Lower Motor Neuron Lesions overallStatus: RECRUITING date: 2024-04 date: 2024-09 date: 2024-09 date: 2024-04-09 date: 2024-04-09 name: Guang'anmen Hospital of China ... |
<|newrecord|> nctId: NCT06354231 id: RC48-C012 briefTitle: DV Combined With Toripalimab for Renal Preservation in Solitary Kidney or Renal Insufficiency or Bilateral Multiple UTUC overallStatus: RECRUITING date: 2023-07-20 date: 2026-12-30 date: 2026-12-30 date: 2024-04-09 date: 2024-04-11 name: Fudan University class:... |
<|newrecord|> nctId: NCT06354218 id: GXL-005 briefTitle: Serplulimab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old Age overallStatus: RECRUITING date: 2023-12-01 date: 2025-12-01 date: 2027-12-01 date: 2024-04-09 date: 2024-04-09 name: The First Affiliated Hospital w... |
<|newrecord|> nctId: NCT06354205 id: 24-3.1T/98 briefTitle: Comparison of Salivary Procalcitonin (PCT) Levels and Serum PCT Levels overallStatus: RECRUITING date: 2024-06-01 date: 2025-03-01 date: 2025-04-01 date: 2024-04-09 date: 2024-04-09 name: Ege University class: OTHER name: THE SCIENTIFIC AND TECHNOLOGICAL RESEA... |
The aim of this study is to evaluate the correlation between serum PCT levels and saliva PCT levels in children suspected of SBE and to determine the diagnostic value of saliva PCT. conditions: Bacterial Infections conditions: Children, Only conditions: Procalcitonin conditions: Saliva studyType: INTERVENTIONAL phases:... |
<|newrecord|> nctId: NCT06354192 id: 0450 briefTitle: Precision Nudging for Hypertension Management: Observational Study overallStatus: NOT_YET_RECRUITING date: 2024-04-11 date: 2025-10-11 date: 2026-10-11 date: 2024-04-09 date: 2024-04-09 name: Lirio class: INDUSTRY name: Cone Health briefSummary: The purpose of the p... |
<|newrecord|> nctId: NCT06354179 id: 87RI23_0031 (EASY) briefTitle: Evaluation of the Benefits of Administering Immunosuppressive Drugs as Single Daily Doses Over the First Year After Liver Transplantation (EASY) acronym: EASY overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2027-07-01 date: 2027-07-01 date: 20... |
The immunosuppressive regimen after liver transplantation is in most cases based on different combinations of tacrolimus, mycophenolate mofetil and corticosteroids. While corticosteroids are administered once daily, tacrolimus can be administered either twice-daily (BID) as an immediate-release, or once-daily (QD) as a... |
Although the half-life of mycophenolic acid (MPA), the active moiety of mycophenolate mofetil (MMF) is compatible with once-daily administration, no published randomized clinical study has ever evaluated the efficacy and safety of MMF administered QD. |
The narrow therapeutic index and wide pharmacokinetic variability of tacrolimus and mycophenolate justify individual dose adjustment by means of therapeutic drug monitoring (TDM), in order to minimize the risk of acute rejection and the occurrence of adverse events. For tacrolimus, TDM is generally based on the trough ... |
Limited sampling strategies with maximum a posteriori Bayesian estimation have been developed by our team for both molecules in adult liver transplant patients to estimate their AUC, which is considered the best marker of exposure for both. Therefore, tacrolimus AUC0-24h can be estimated by Bayesian estimation using sa... |
Even if limited to 2 or 3 blood samples, tacrolimus TDM for ENVARSUS® requires late sampling (12h post-dose). To overcome the necessity of a longer hospital stay, microsampling devices (MSD) such as the Volumetric absorptive microsampling (VAMS®) device (Mitra®) can be used by the patients to take samples themselves, a... |
In this context, we propose a randomized controlled non-inferiority study to demonstrate that in liver transplant recipients, an immunosuppressive strategy based on single daily doses of LCP-tacrolimus (ENVARSUS XR®) and mycophenolate mofetil (CELLCEPT®) started at M6 post-transplantation is not inferior to XR-tacrolim... |
<|newrecord|> nctId: NCT06354166 id: 2023-A02745-40 briefTitle: Study Human Digital Support Transitional Care acronym: SUNH-ST overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-03 date: 2025-03 date: 2024-04-09 date: 2024-04-09 name: Divoluci class: OTHER briefSummary: The purpose of the study is to compare th... |
<|newrecord|> nctId: NCT06354153 id: 0305898 briefTitle: Polarity Management Training Program for First Line Nurse Manager overallStatus: COMPLETED date: 2022-12-01 date: 2023-04-30 date: 2023-04-30 date: 2024-04-09 date: 2024-04-09 name: Matrouh University class: OTHER briefSummary: Polarities are vital issues in heal... |
<|newrecord|> nctId: NCT06354140 id: WeGuo briefTitle: PPIO-008S-1 Combined With Tislelizumab in Patients With Primary Residual Node-negative Esophageal Squamous Cell Carcinoma (ESCC) After Radical Resection With Neoadjuvant Immunotherapy Combined With Chemotherapy, PHASE II STUDY overallStatus: RECRUITING date: 2024-0... |
<|newrecord|> nctId: NCT06354127 id: DW_DWP450009 briefTitle: DWP450 for Treating Moderate to Severe Glabellar Lines overallStatus: COMPLETED date: 2020-08-12 date: 2020-11-24 date: 2021-01-25 date: 2024-04-09 date: 2024-04-09 name: Daewoong Pharmaceutical Co. LTD. class: INDUSTRY briefSummary: A multi-center, randomiz... |
<|newrecord|> nctId: NCT06354114 id: SYHX2011-003 briefTitle: A Study to Evaluate the Efficacy and Safety in Subjects With Advanced Breast Cancer Treated With SYHX2011 overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-10-31 date: 2026-12 date: 2024-04-09 date: 2024-04-09 name: CSPC Ouyi Pharmaceutical Co., Ltd... |
<|newrecord|> nctId: NCT06354101 id: CorEvitas-VITALITY briefTitle: The Purpose of This Registry Study is to Learn More About Metabolic Health: Approximately 15,000 Participants Who Are Overweight or Have Obesity With or Without Metabolic Diseases Are Expected to Participate in This Registry Study. overallStatus: WITHD... |
<|newrecord|> nctId: NCT06354088 id: AAAU9636 briefTitle: Human Models of Selective Insulin Resistance: Alpelisib, Part I overallStatus: RECRUITING date: 2024-04-24 date: 2026-05 date: 2026-12 date: 2024-04-09 date: 2024-04-29 name: Columbia University class: OTHER name: University of California, Berkeley briefSummary:... |
The objective is to evaluate the effect of lowering insulin levels, while maintaining constant mild hyperglycemia, on plasma glucose and lipid levels. conditions: Insulin Resistance conditions: Prediabetic State conditions: Overweight and Obesity conditions: Non-Alcoholic Fatty Liver Disease studyType: INTERVENTIONAL p... |
<|newrecord|> nctId: NCT06354075 id: IRBN302024/CHUSTE briefTitle: Evaluation of Patient Information in Interventional Radiology overallStatus: RECRUITING date: 2024-04-01 date: 2026-03 date: 2026-03 date: 2024-04-09 date: 2024-04-10 name: Centre Hospitalier Universitaire de Saint Etienne class: OTHER briefSummary: Int... |
<|newrecord|> nctId: NCT06354062 id: 0305896 briefTitle: Talent Management Intervention Program for First-Line Nurse Managers overallStatus: COMPLETED date: 2022-12-01 date: 2023-04-30 date: 2023-04-30 date: 2024-04-09 date: 2024-04-09 name: Matrouh University class: OTHER briefSummary: Nurse leaders will be required t... |
<|newrecord|> nctId: NCT06354049 id: CASE3Z24 briefTitle: Reiki Therapy to Improve Key Symptoms in Integrative Oncology Clinic (REIKI) overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2024-12-31 date: 2025-03-31 date: 2024-04-09 date: 2024-04-09 name: Case Comprehensive Cancer Center class: OTHER briefSummary: ... |
<|newrecord|> nctId: NCT06354036 id: NCC4465 briefTitle: Transhiatal Tunnel Valvuloplasty for Reconstruction Following the Laparoscopic Proximal Gastrectomy overallStatus: RECRUITING date: 2023-03-01 date: 2025-03-01 date: 2025-03-01 date: 2024-04-09 date: 2024-04-10 name: Cancer Institute and Hospital, Chinese Academy... |
Review the surgical video and record the time for making the extracorporeal muscle flap, tunnel passage time, and anastomosis time. The production time of the muscle flap is based on the electric knife incision of the muscle flap as the starting point, and successfully penetrating the muscle flap as the endpoint. The t... |
Postoperative pathology was performed using the 8th edition AJCC staging. Follow up every three months after surgery, including blood tests, liver and kidney function, and tumor markers. According to the situation, choose gastroscopy, upper gastrointestinal imaging, and chest abdominal pelvic enhanced CT. Evaluate post... |
<|newrecord|> nctId: NCT06354023 id: IAGH for Osteoarthritis briefTitle: Human Growth Hormone Injections in the Knee Joint to Treat Osteoarthritis overallStatus: NOT_YET_RECRUITING date: 2024-05-08 date: 2025-05-08 date: 2025-05-08 date: 2024-04-09 date: 2024-04-17 name: John Sledge class: OTHER briefSummary: The goal ... |
* Do growth hormone injections in the knee joint stimulate cartilage growth? |
* Do the injections lower pain and stiffness in the participant's treated knee? |
* Does the participant have more mobility after the injections? |
The physician will monitor the participant's progress through X-ray images, questionnaires, and physical evaluation of the treated knee. |
For the trial, participants will: |
* Receive a growth hormone injection in their knee once per week for six weeks, for a total of 6 injections. |
* Complete at-home exercises during the treatment period. |
* Use crutches as needed during the trial. |
* Have X-rays taken at 8 weeks, 6 months, and 12 months after the first injection. |
* Go to follow-up visits at 8 weeks, 6 months, and 12 months after the first injection. |
* Complete treatment surveys before treatment starts and after it is finished. conditions: Osteoarthritis, Knee studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: The proposed clinical trial is a single-arm intervention model. Once per week for six week... |
<|newrecord|> nctId: NCT06354010 id: SENS-NH02 briefTitle: Cross-sectional and Prospective Study to Characterize Early-onset Presbycusis acronym: SONG overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-07 date: 2027-07 date: 2024-04-09 date: 2024-04-09 name: Sensorion class: INDUSTRY briefSummary: The purpose o... |
<|newrecord|> nctId: NCT06353997 id: 2024000099 briefTitle: Neoadjuvant INBRX-106 (Hexavalent OX40 Agonist) in Combination With Pembrolizumab as a Chemotherapy-sparing Regimen for Stage II TNBC (Triple Negative Breast Cancer) Patients overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-06 date: 2029-06 date: 202... |
<|newrecord|> nctId: NCT06353984 id: Minimeal 1.0 briefTitle: Effects of In-between Meal Products on Cognitive Function in Older Adults acronym: Minimeal overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-12 date: 2025-12 date: 2024-04-09 date: 2024-04-09 name: Örebro University, Sweden class: OTHER briefSummar... |
<|newrecord|> nctId: NCT06353971 id: JSP-CP-010 id: 2023-507534-24 type: EUDRACT_NUMBER briefTitle: A Dose Escalation Trial of Safety, Pharmacokinetic/Pharmacodynamic and Preliminary Clinical Activity of Briquilimab in Adult Patients With Chronic Inducible Urticaria (CIndU) Who Remain Symptomatic Despite Treatment With... |
Cohort 1 follows a 3+3 design and will be treated with a single 40mg dose. Cohort 2 will be treated with a single 120mg dose. primaryPurpose: TREATMENT masking: NONE count: 18 type: ESTIMATED name: Briquilimab measure: Incidence and severity of treatment emergent AEs/SAEs [safety and tolerability] of a single dose of b... |
<|newrecord|> nctId: NCT06353958 id: MiSaver PIIa briefTitle: MiSaver® Stem Cell Treatment for Acute Myocardial Infarction acronym: MiSaver® overallStatus: COMPLETED date: 2023-01-01 date: 2023-12-31 date: 2023-12-31 date: 2024-04-09 date: 2024-04-09 name: Honya Medical Inc class: INDUSTRY name: Chung Shan Medical Univ... |
Primary Endpoint: |
The primary endpoint focused on safety and adverse events over a 12-month observational period. Results showed the treatment was well-tolerated with no AEs attributed to the study product. |
Secondary Outcomes: |
Secondary outcomes evaluated changes in left ventricular ejection fraction (LVEF) from baseline to 12 months post-treatment. A retrospective study compared eligible controls with low and middle dosage groups. conditions: Acute Myocardial Infarction studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspecti... |
<|newrecord|> nctId: NCT06353945 id: HB062-24 briefTitle: Perceived Effectiveness of the Vaginal Moisturizer Investigational Product Under Normal Conditions of Use. overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2024-05-07 date: 2024-05-15 date: 2024-04-09 date: 2024-04-09 name: Herbarium Laboratorio Botanico... |
<|newrecord|> nctId: NCT06353932 id: KA-23026 briefTitle: The Effect of Monitoring Endotracheal Tube Cuff Pressure and Keeping it in a Certain Range overallStatus: COMPLETED date: 2024-01-25 date: 2024-02-25 date: 2024-02-25 date: 2024-04-09 date: 2024-04-09 name: Hacettepe University class: OTHER briefSummary: The mai... |
<|newrecord|> nctId: NCT06353919 id: NUNM briefTitle: Remote Yoga Nidra for Deprescribing BZRAs overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-05-31 date: 2025-05-31 date: 2024-04-09 date: 2024-04-09 name: National University of Natural Medicine class: OTHER name: US Department of Veterans Affairs briefS... |
<|newrecord|> nctId: NCT06353906 id: N22APC briefTitle: Carboplatin/Paclitaxel + Pembrolizumab for Locoregionally Advanced Penile Cancer acronym: PRIAM overallStatus: NOT_YET_RECRUITING date: 2024-06-14 date: 2026-10-14 date: 2028-01-14 date: 2024-04-09 date: 2024-04-09 name: The Netherlands Cancer Institute class: OTH... |
<|newrecord|> nctId: NCT06353893 id: Integrity-001 briefTitle: MRI Evaluation of Integrity Bio-Inductive Implant for Rotator Cuff Tears overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-12-01 date: 2026-05-01 date: 2024-04-09 date: 2024-04-09 name: Foundation for Orthopaedic Research and Education class: OT... |
* How does the application of the Integrity implant affect patient-reported outcome measures (PROMs) such as ASES, SANE, and PROMIS? |
* What are the imaging characteristics of the rotator cuff tears at 3 and 6 months postoperatively when using the Integrity implant? |
Postoperative MRIs will be obtained from 10 consecutive patients who have undergone rotator cuff repair using the Integrity implant at 3 and 6 months after surgery. Participants include those with partial and full thickness tears treated with different surgical techniques involving the implant. They may receive either ... |
<|newrecord|> nctId: NCT06353880 id: 24K08-001 briefTitle: Obesity With Sperm Quality in Men With Fertility Need overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-06 date: 2025-12 date: 2024-04-09 date: 2024-04-09 name: Yu xiaowei class: OTHER briefSummary: This study aims to investigate the impact of differen... |
<|newrecord|> nctId: NCT06353867 id: 56365223-050.01.04-2023.13754 briefTitle: The Effect of Group Exercise in Children With Special Needs overallStatus: COMPLETED date: 2022-12-27 date: 2023-04-15 date: 2023-04-25 date: 2024-04-09 date: 2024-04-09 name: Istanbul Gedik University class: OTHER briefSummary: Thirty child... |
<|newrecord|> nctId: NCT06353854 id: FFCD 2112-CORESIM briefTitle: Prospective Cohort Study of Immunotherapy Resistance in Metastatic Colorectal Cancer Patients With MSI acronym: CORESIM overallStatus: RECRUITING date: 2024-02-12 date: 2029-02-12 date: 2030-02-12 date: 2024-04-09 date: 2024-04-09 name: Federation Franc... |
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