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Schematically, after recognition of the MHC-peptide complex by the TCR, the T lymphocyte response is modulated by several activating or inhibiting co-stimulatory signals (or "checkpoints"). The balance of these different signals determines whether the T lymphocyte (LT) is activated, resulting in the destruction of the ... |
However, the efficacy of ICIs varies from one cancer to another. In addition to the expression of PDL1 by the tumour and/or immune cells, and the mutational load, one of the primary factors predicting response to immunotherapy mentioned in several studies is microsatellite instability (MSI). conditions: Colorectal Canc... |
<|newrecord|> nctId: NCT06353841 id: 2023/435 briefTitle: Effect of Therapeutic Touch on Functional Constipation in Infants and Young Children overallStatus: RECRUITING date: 2023-05-03 date: 2024-05-01 date: 2024-12-31 date: 2024-04-09 date: 2024-04-09 name: Burdur Mehmet Akif Ersoy University class: OTHER briefSummar... |
<|newrecord|> nctId: NCT06353828 id: ICBD-UC-01 briefTitle: Phase 2a Study to Evaluate IcBD-01 Enema in Active Ulcerative Colitis Patients overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-01 date: 2024-04-01 date: 2025-04-01 date: 2024-04-09 date: 2024-04-09 name: CannaMore Biotechs class: INDUSTRY briefSummary: Ulce... |
Based on positive safety and initial efficacy profiles of CBD found in IBD animal and clinical studies, the main aim of this study is to evaluate the safety, tolerability and efficacy of a novel enema formulation of CBD for the treatment of active ulcerative proctitis. conditions: Ulcerative Colitis studyType: INTERVEN... |
<|newrecord|> nctId: NCT06353815 id: anaesthetic efficacy briefTitle: Clinical Evaluation of Anaesthetic Efficacy of 4% Articaine Buccal Infiltration Versus Inferior Alveolar Nerve Block overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2025-02 date: 2025-06 date: 2024-04-09 date: 2024-04-09 name: Cairo University ... |
<|newrecord|> nctId: NCT06353802 id: P.T.REC/012/004963 briefTitle: Relationship Between Chronic Non-Specific Neck Pain And Lumbar Reposition Sense overallStatus: ACTIVE_NOT_RECRUITING date: 2023-09-01 date: 2024-04 date: 2024-05 date: 2024-04-09 date: 2024-04-09 name: Cairo University class: OTHER briefSummary: to inv... |
<|newrecord|> nctId: NCT06353789 id: RoADPain Clinical Study briefTitle: Adolescent Dysmenorrhoea as a Risk Factor for Chronic Pain: Clinical Cohort Study acronym: RoADPain overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-01 date: 2027-05-01 date: 2024-04-09 date: 2024-04-09 name: University of Oxford c... |
<|newrecord|> nctId: NCT06353776 id: 02052023 briefTitle: MicroPulse Transscleral Laser Therapy and Its Short-term Impact on Ocular Surface overallStatus: COMPLETED date: 2023-05-03 date: 2023-10-31 date: 2023-10-31 date: 2024-04-09 date: 2024-04-09 name: University Tunis El Manar class: OTHER briefSummary: MicroPulse ... |
<|newrecord|> nctId: NCT06353763 id: CV briefTitle: Design, Implementation, and Evaluation of Virtual Reality in the Nursing Curriculum overallStatus: COMPLETED date: 2022-02-24 date: 2022-05-30 date: 2022-06-30 date: 2024-04-09 date: 2024-04-09 name: Clinica Universidad de Navarra, Universidad de Navarra class: OTHER ... |
The design was an exploratory randomised controlled trial. The variables used to measure effectiveness were competence and its attributes: knowledge assessment by a multiple-choice test (Pressure Ulcer Knowledge Assessment Tool, Pukat 2.0 instrument), skill performance by direct observation of procedural skills (simula... |
<|newrecord|> nctId: NCT06353750 id: 331039 briefTitle: Intracellular Magnesium and Heart Failure overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-02-28 date: 2026-04-25 date: 2024-04-09 date: 2024-04-09 name: University of Oxford class: OTHER name: British Heart Foundation name: Oxford University Hospital... |
<|newrecord|> nctId: NCT06353737 id: CTO 4489 briefTitle: Looking for Asymptomatic Mpox in a Population at High Risk acronym: LAMP overallStatus: RECRUITING date: 2024-04-01 date: 2026-03-31 date: 2026-03-31 date: 2024-04-09 date: 2024-04-18 name: Unity Health Toronto class: OTHER briefSummary: Mpox is caused by a viru... |
<|newrecord|> nctId: NCT06353724 id: RP2218 briefTitle: Comparison Between the Effect of Using Conventional and Digital Oral Positional Radiation Stent acronym: stent overallStatus: COMPLETED date: 2019-10-14 date: 2020-10-01 date: 2021-01-01 date: 2024-04-09 date: 2024-04-09 name: Tanta University class: OTHER briefSu... |
Participants will use radiation positioning stent during radiotherapy sessions Two groups will be compared |
* Group A: OPRS was constructed according to the conventional technique. |
* Group B: OPRS was constructed digitally using CAD /CAM technology. to evaluate Dosimetric analysis to quantify the radiation dose in OARs, PH of saliva measurement and Mucositis assessment. conditions: Radiotherapy Side Effect studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL pri... |
<|newrecord|> nctId: NCT06353711 id: IRB-23-0746 id: R34MH129782 type: NIH link: https://reporter.nih.gov/quickSearch/R34MH129782 briefTitle: CA-LINC Black Youth Suicide Detection and Intervention Study acronym: CA-LINC overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-03 date: 2025-05 date: 2024-04-09 date: 2... |
CA-LINC is a 90-day culturally adapted LINC intervention developed with and for Black youth. The CA-LINC intervention integrates engagement and follow-up strategies to assess/monitor suicide risk, facilitate service use referrals/linkages, develop/refine safety plans, and create villages of care. The CA-LINC interventio... |
CA-LINC is implemented by Peer Support Specialists and Community Health Workers assigned to mental health "hubs" in Black Faith-Based Organizations (FBOs) that facilitate standardization and access to care for Black youth/families regardless of religious affiliation. Black FBOs effectively mobilize Black communities to... |
<|newrecord|> nctId: NCT06353698 id: Nnftri briefTitle: Fasting Mimicking Diet With Chemotherapy in Patients With Leukemia overallStatus: RECRUITING date: 2023-07-02 date: 2024-04-01 date: 2024-05-01 date: 2024-04-09 date: 2024-04-09 name: National Nutrition and Food Technology Institute class: OTHER briefSummary: The ... |
<|newrecord|> nctId: NCT06353685 id: neo-CHART-HNC briefTitle: De-Escalation Postoperative Radiotherapy for Oral Squamous Cell Carcinoma With pCR/MPR. overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-12-31 date: 2028-12-31 date: 2024-04-09 date: 2024-04-19 name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen... |
Continuous hyperfractionated accelerated radiotherapy (CHART, based on hyperfractionated radiotherapy, increasing daily or weekly treatments and shortening the total treatment duration, but reducing the total dose), is to give a higher dose of radiation to tumor tissue in a shorter period of time, so as to overcome the... |
<|newrecord|> nctId: NCT06353672 id: RLR-01 briefTitle: A Study to Evaluate Safety and Feasibility of Robotic Liver Resection overallStatus: RECRUITING date: 2020-12-01 date: 2025-12-31 date: 2026-12-31 date: 2024-04-09 date: 2024-04-09 name: Zhejiang University class: OTHER briefSummary: The robotic surgery system, th... |
This study aimed to evaluate safety and feasibility of robotic liver resection, by comparing it with LLR or OLR, and gain veritable and relevant data on the benefits of RLR. conditions: Liver Diseases conditions: Surgery studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose:... |
<|newrecord|> nctId: NCT06353659 id: M2024077 briefTitle: The Diagnostic Value of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-06-30 date: 2026-06-30 date: 2024-04-09 date: 2024-04-09 name: Peking University Third Hospital class: OTHER briefSum... |
<|newrecord|> nctId: NCT06353646 id: XKY-C-004 briefTitle: XH001 Combination With Ipilimumab and Chemotherapy for Patients With Resected Pancreatic Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-06 date: 2026-12 date: 2024-04-09 date: 2024-04-09 name: Wu Wenming class: OTHER name: NeoCura briefSummar... |
<|newrecord|> nctId: NCT06353633 id: AHekmatdoost briefTitle: The Effect of Exclusion Diet for Crohn's Disease Plus Enteral Nutrition on Children and Adolescents With Crohn's Disease overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-10-20 date: 2024-12-25 date: 2024-04-09 date: 2024-04-09 name: National Nut... |
<|newrecord|> nctId: NCT06353620 id: 1018 briefTitle: Structural-functional Connectome in Drug-resistant Epilepsies and Neurodevelopmental Syndromes With Epilepsy overallStatus: RECRUITING date: 2024-02-13 date: 2024-03-18 date: 2027-02-28 date: 2024-04-09 date: 2024-04-09 name: IRCCS Eugenio Medea class: OTHER briefSu... |
<|newrecord|> nctId: NCT06353607 id: 2023-02267; kt23Berdajs briefTitle: Genetic Architecture of Acute Aortic Syndromes and Aortic Aneurysm. overallStatus: RECRUITING date: 2024-04-08 date: 2028-12-31 date: 2028-12-31 date: 2024-04-09 date: 2024-04-22 name: University Hospital, Basel, Switzerland class: OTHER briefSumm... |
<|newrecord|> nctId: NCT06353594 id: COPERNICAN TRIAL briefTitle: Reduced Stent Strategy Versus Conventional Percutaneous Coronary Revascularization in Patients Presenting With STEMI acronym: COPERNICAN overallStatus: RECRUITING date: 2024-03-11 date: 2026-09 date: 2035-09 date: 2024-04-09 date: 2024-04-09 name: Jorge ... |
Randomization will be performed after successful culprit-lesion guidewire crossing and flow restoration. Random allocation in a 1:1 fashion to one of the following strategies: |
* Study group: reduced stent PCI strategy (DCB-based) |
* Control group: conventional PCI strategy (DES-based). conditions: ST Elevation Myocardial Infarction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 1272 type: ESTIMATED name: Primary PCI measure: Target lesion failure (TLF) measur... |
<|newrecord|> nctId: NCT06353581 id: 4-2021-0924 briefTitle: Prophylactic Administration of Neulapeg (Pegteograstim) in Patients With Locally Advanced or Metastatic Pancreatic Cancer Receiving the Modified FOLFIRINOX overallStatus: ACTIVE_NOT_RECRUITING date: 2022-02-16 date: 2024-05-08 date: 2024-05-08 date: 2024-04-0... |
<|newrecord|> nctId: NCT06353568 id: 5.888.210 briefTitle: Effect of Photobiomodulation as a Preventive Treatment for Diabetic Foot overallStatus: NOT_YET_RECRUITING date: 2024-05-30 date: 2027-10-30 date: 2027-12-30 date: 2024-04-09 date: 2024-04-09 name: University of Nove de Julho class: OTHER briefSummary: This stu... |
The Control Group will use a non-therapeutic LED boot (placebo) for 6 minutes once daily for 60 days and will also receive therapeutic education. |
Participants will be assessed at the beginning of the study (baseline) and after 30 days (clinical examination) and 60 days (clinical examination, assessment of Peripheral neuropathy, assessment of peripheral artery disease, blood and urine tests, and quality of life evaluation). primaryPurpose: PREVENTION masking: TRI... |
* 1 Vascular surgeon researcher who will perform Doppler ultrasound, Ankle-Brachial Index (ABI), and Toe-Brachial Index (TBI) measurements during the initial assessment and follow-up examinations, without knowledge of the subjects' allocation. |
* 1 Nurse researcher who will retrieve the allocation envelope and provide the appropriate PBM equipment (active or placebo), as well as provide recommendations for its use at home. |
* 1 Researcher, who will not participate in any assessments, will prepare randomization and envelopes to ensure allocation confidentiality. |
* 2 physician residents who will provide daily contact for device usage control, guidance, addressing inquiries, etc. whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 64 type: ESTIMATED name: Photobiomodulation name: Simulation of Photobiomodulation name: Therapeutic education measure:... |
<|newrecord|> nctId: NCT06353555 id: PUMCH-20240311 briefTitle: Efficacy of Thyroid Hormone Replacement for Secondary Hypothyroidism Following Intracerebral Hemorrhage overallStatus: RECRUITING date: 2023-10-11 date: 2025-06-01 date: 2025-12-31 date: 2024-04-09 date: 2024-04-09 name: Peking Union Medical College Hospit... |
Patients with severe neurological diseases often experience more complications and exhibit higher mortality rates, and many studies have provided evidence for a low T3/T4 state being an important prognostic indicator in such cases; Lieberman et al. found that 87% of individuals with severe traumatic brain injury have t... |
As acute progression ceases, thyroid hormone levels may return to normal. This may imply that thyroid hormone supplements could improve the prognosis of patients with secondary hypothyroidism. Previous clinical studies have examined the effect of thyroid HRT on patients undergoing cardiac surgery; patients with malnutr... |
The application of hormone replacement therapy in the treatment of neurocritical patients with secondary hypothyroidism remains controversial. |
This study aims to explore the safety and effectiveness of thyroid hormone replacement therapy in patients with spontaneous intracerebral hemorrhage and concomitant secondary hypothyroidism. conditions: Intracerebral Hemorrhage conditions: Low T3 Syndrome conditions: Neurocritical Care conditions: Hormone Replacement T... |
<|newrecord|> nctId: NCT06353542 id: HCB/2023/1206 id: PI23/01856 type: OTHER domain: Institut d'Investigacions Biomèdiques August Pi i Sunyer briefTitle: Barcelona Esquerra Glaucoma Artificial Intelligence-based Screening Program (BEGAS) acronym: BEGAS overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2026-03 d... |
Subjects between 45 to 64 years old living in the metropolitan area of Barcelona will be invited to participate in a one-time visit, with an optic disc examination and intraocular pressure (IOP). |
The criteria for referring a patient will be the detection of glaucoma but with two different approaches depending on which Integrated Practice Unit (IPU) the patients will be allocated to: one arm using an Artificial Intelligence (AI) reading software of the optic disc picture; and the other one will base their referr... |
In both circuits, an optic nerve head photography will be obtained, and a masked reading center will be established to determine the ground truth for diagnosis. |
This screening trial will explore the level of agreement between both systems and the cost-effectiveness of each of them. |
Secondary analyses will include potential diagnostic composite scores (including other ancillary tests, such as optical coherence tomography images, that could maximize the screening process); the identification of population and disease characteristics (type of glaucoma, intraocular pressure) that could increase the e... |
<|newrecord|> nctId: NCT06353529 id: 17065 briefTitle: Sphenopalatine Ganglion Block for Postop Pain Management acronym: SPGB overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-05 date: 2024-04-09 date: 2024-04-09 name: Hamilton Health Sciences Corporation class: OTHER briefSummary: To assess the ... |
<|newrecord|> nctId: NCT06353516 id: 2310-117-126 briefTitle: The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients overallStatus: RECRUITING date: 2024-02-14 date: 2024-09 date: 2024-12 date: 2024-04-09 date: 2024-04-09 name: Chung-Ang University Gwangmyeong Ho... |
* \[Is the permeability of blood-brain barrier between the intravenous anesthesia group and the inhalation gas anesthesia group in the elderly patients different?\] |
* \[Is the incidence of postoperative cognitive dysfunction between the intravenous anesthesia group and the inhalation gas anesthesia group different?\] Participants will be anesthetized with different categories of anesthetics. |
* Intravenous anesthetics |
* Inhalation gas anesthetics conditions: Postoperative Cognitive Dysfunction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The participants are randomly assigned to total intravenous anesthesia group or inhaled gas anesthesia group primaryPurpose... |
<|newrecord|> nctId: NCT06353503 id: KAZ briefTitle: Bone Marrow Aspirate Concentrate for Anterior Cruciate Ligament Tear Treatment. overallStatus: RECRUITING date: 2024-04-02 date: 2024-09-27 date: 2024-09-27 date: 2024-04-09 date: 2024-04-09 name: abdulmajeed hammadi class: INDUSTRY briefSummary: A single armed multi... |
<|newrecord|> nctId: NCT06353490 id: Geon-111001 briefTitle: The Clinical Performance Validation of Electronic Thermometer and Infrared Thermometers overallStatus: ACTIVE_NOT_RECRUITING date: 2022-08-12 date: 2023-11-08 date: 2024-08-11 date: 2024-04-09 date: 2024-04-09 name: Geon Corporation class: INDUSTRY briefSumma... |
The main objectives of this study are: |
1. To verify that the investigational devices and the reference medical devices have a reasonable deviation value. |
2. To verify the consistency of repeated measurements of investigational devices. conditions: Febrile conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 150 type: ACTUAL name: Infrared Forehead Thermometer (GE-TF03) ... |
<|newrecord|> nctId: NCT06353477 id: EOU 2019-10 briefTitle: Hand, Foot, and Mouth Disease: Could EPs®7630 be a Treatment Option overallStatus: COMPLETED date: 2019-06-01 date: 2022-06-01 date: 2023-01-01 date: 2024-04-09 date: 2024-04-09 name: Eskisehir Osmangazi University class: OTHER name: Abdi Ibrahim Ilac San. ve... |
<|newrecord|> nctId: NCT06353464 id: 2306009984 briefTitle: A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation acronym: OPBIM overallStatus: RECRUITING date: 2023-10-04 date: 2025-09 date: 2025-09 date: 2024-04-09 date: 2024-04-09 name: Drexel University class: OTHER briefS... |
<|newrecord|> nctId: NCT06353451 id: EK GZ 67/2021-2024 briefTitle: Digital Detox Study: A Randomized Controlled Trial overallStatus: COMPLETED date: 2023-10-23 date: 2024-01-21 date: 2024-01-21 date: 2024-04-09 date: 2024-04-09 name: Danube University Krems class: OTHER briefSummary: The aim of the present RCT is to i... |
After inclusion and randomization to intervention- and control group, normal screen time behavior will be assessed for 10-days. After that, the mental health parameters will be carried out in both groups as a baseline survey (T0). After that, intervention group should limit smartphone screen time to less than 2 hours p... |
Main outcome parameters are 1) Well-Being (WHO-5), depressive symptoms (PHQ-9), stress (PSQ-20), and sleep quality (ISI). |
The primary hypothesis (stated at Open Science Framework before Enrollment: https://osf.io/a9k76) is that mental health indicators, particularly stress, depressive symptoms, and sleep quality will improve throughout the intervention compared to the control group as well as to baseline. conditions: Health Behavior study... |
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