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* Does spinal analgesia result in improved recovery as quantified by QoR-15 at POD 7, the incidence of postoperative pain at rest and at mobilization, nausea and vomiting, the need for opioid analgesics, time out-of-bed, length of stay and the incidence of complications? |
* Does spinal analgesia increase workload in the OR, as quantified by time from arrival in the OR to start of surgery? |
* Does spinal analgesia result in an increased incidence of hypotension and cardiac dysfunction during surgery, as well as an increased incidence of pruritus after surgery? |
Participants will be randomized to receive either spinal analgesia with bupivacaine and morphine preoperatively or an intravenous infusion with lidocaine intraoperatively. |
QoR-15 and other markers of recovery will be registered using structured interviews preoperatively, at POD1 and POD7. In addition, patients will record pain at rest and at mobilization three times daily in a diary. |
In a subgroup of patients advanced hemodynamic parameters will be recorded using pulse-contour analysis before, during and after surgery. Blood samples will also be collected in these patients at fixed intervals and analyzed for amongst others inflammation and cardiac dysfunction. conditions: Other Specified Disorders ... |
<|newrecord|> nctId: NCT06349655 id: 2023-KY-0865-001 briefTitle: The Real-world Clinical Study of Azvudine Tablets in the Treatment of COVID-19 overallStatus: COMPLETED date: 2023-12-05 date: 2024-01-15 date: 2024-03-10 date: 2024-04-05 date: 2024-04-05 name: The First Affiliated Hospital of Zhengzhou University class... |
<|newrecord|> nctId: NCT06349642 id: MC230901 id: 23-008413 type: OTHER domain: Mayo Clinic Institutional Review Board id: NCI-2024-02979 type: REGISTRY domain: CTRP (Clinical Trials Reporting Program) briefTitle: Predicting Response to Immune Checkpoint Inhibitors Across Solid Tumors Using a Live Tumor Diagnostic Plat... |
<|newrecord|> nctId: NCT06349629 id: 20240401 briefTitle: The Clinical Study of 3D-printed Magnesium Alloy Prosthesis With Controllable Degradation Rate in the Repair of Periarticular Bone Defects overallStatus: RECRUITING date: 2023-01-01 date: 2025-01-01 date: 2027-01-01 date: 2024-04-05 date: 2024-04-05 name: Peking... |
<|newrecord|> nctId: NCT06349616 id: STUDY24458 briefTitle: Cooling Strategies for Older Adults in the Heat overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-12 date: 2026-12 date: 2024-04-05 date: 2024-04-05 name: Penn State University class: OTHER briefSummary: The earth's climate is warming, and the number ... |
There is compelling evidence that intermittent hand and forearm cold-water immersion effectively reduces the rise of core temperature during heat stress in older adults. However, it is still unknown if this is an effective cooling strategy for older adults. Furthermore, our laboratory has shown that folic acid suppleme... |
<|newrecord|> nctId: NCT06349603 id: S2023 briefTitle: Physiotherapy Approach for Susac Syndrome overallStatus: COMPLETED date: 2023-02-13 date: 2023-04-01 date: 2023-04-06 date: 2024-04-05 date: 2024-04-05 name: Rehabilitation Centre Zivot class: OTHER briefSummary: Susac's syndrome is a rare autoimmune disorder chara... |
<|newrecord|> nctId: NCT06349590 id: IRB24-0373 briefTitle: Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery acronym: DIET overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2029-04 date: 2029-04 date: 2024-04-05 date: 202... |
<|newrecord|> nctId: NCT06349577 id: 23-0921 id: 5K23HL151882 type: NIH link: https://reporter.nih.gov/quickSearch/5K23HL151882 briefTitle: Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-04 date: 2028-10 date: 2024-04-05 date... |
<|newrecord|> nctId: NCT06349564 id: 23-01443 briefTitle: Implementing Virtual Reality (VR) to Reduce Sedation overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-05 date: 2024-04-05 name: NYU Langone Health class: OTHER briefSummary: The study is a prospective pilot patients aged ... |
<|newrecord|> nctId: NCT06349551 id: RC23_0586 briefTitle: Clot Formation and Coagulation Factors Consumption in the Clearing Fluid After Arterial Catheter Blood Sampling. acronym: SECU-BIO2 overallStatus: RECRUITING date: 2024-04-17 date: 2025-03-20 date: 2025-03-20 date: 2024-04-05 date: 2024-04-18 name: Nantes Unive... |
<|newrecord|> nctId: NCT06349538 id: 35-435 ex 22/23 briefTitle: Identifying Markers of Disease Subtypes and Disease Progression in the Syndrome of Essential Tremor overallStatus: ENROLLING_BY_INVITATION date: 2024-04-04 date: 2026-04-30 date: 2034-04-30 date: 2024-04-05 date: 2024-04-16 name: Medical University of Gra... |
* The prevalence of ET-plus compared to ET in a prospectively collected ET population. |
* To assess in detail the heterogenous group of ET patients using comprehensive clinical (motor and non-motor scales, questionnaires), imaging \[magnetic resonance imaging (MRI), sonography of substantia nigra and cerebral vessels\], neurophysiological (tremor analysis, digital spiral drawing) and laboratory markers (s... |
* To assess possible non-invasive markers of neurodegeneration in ET patients (optic coherence tomography, alpha-synuclein in olfactory mucosa) |
Participants will be asked to undergo the above mention evaluation at baseline and at follow-up approx. 5 years later. |
Researchers will compare the findings within the ET group to independently existing cohorts of healthy controls and/or patients with other movement disorders like Parkinson's disease. conditions: Essential Tremor studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED... |
<|newrecord|> nctId: NCT06349525 id: DU-2021-00103 briefTitle: Retention of Telescopic Versus Locator Attachments overallStatus: COMPLETED date: 2021-04-01 date: 2023-07-05 date: 2023-10-01 date: 2024-04-05 date: 2024-04-09 name: Delta University for Science and Technology class: OTHER briefSummary: Forty patients ( 24... |
<|newrecord|> nctId: NCT06349512 id: IC 2022-07 id: 2023-507860-37-00 type: CTIS briefTitle: 68Ga-FAPI-46 PET/CT for Predicting Histological Response in Triple-negative Breast Cancer (FAP-IT) acronym: FAP-IT overallStatus: NOT_YET_RECRUITING date: 2024-06-15 date: 2027-07-30 date: 2027-07-30 date: 2024-04-05 date: 2024... |
<|newrecord|> nctId: NCT06349499 id: CIIPCL-AMD-MAG-23 briefTitle: [Trial of device that is not approved or cleared by the U.S. FDA] overallStatus: WITHHELD date: 2024-04-05 date: 2024-04-05 name: [Redacted] hasResults: False |
<|newrecord|> nctId: NCT06349486 id: KMUHIRB-F(II)-20230179 briefTitle: Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy, Vonoprazan-amoxicillin Dual Therapy and Proton Pump Inhibitor-based Standard Triple Therapy for Hp Eradication overallStatus: RECRUITING date: 2023-11-28 date: 2026-12-31 date: 2026-12-31... |
2. To investigate the impacts of antibiotic resistance of H. pylori as well as CYP3A4, CYP2C19 and IL-1B -511 genotypes of host on the eradication efficacies of anti-H. pylori treatments. conditions: Helicobacter Pylori Eradication studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL ... |
2. vonoprazan-amoxicillin dual therapy |
3. proton pump inhibitor-based standard triple therapy primaryPurpose: TREATMENT masking: NONE count: 780 type: ESTIMATED name: vonoprazan, amoxicillin, tripotassium dicitrate bismuthate name: vonoprazan, amoxicillin name: rabeprazole, amoxicillin, clarithromycin measure: the eradication rate of Helicobacter pylori mea... |
<|newrecord|> nctId: NCT06349473 id: SR604-1 briefTitle: A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B) overallStatus: RECRUITING date: 2024-04-15 date: 2025-09-27 date... |
<|newrecord|> nctId: NCT06349460 id: STU00216998 id: R01DK133300 type: NIH link: https://reporter.nih.gov/quickSearch/R01DK133300 briefTitle: A Micro-Randomized Trial to Optimize Just-in-Time Adaptive Intervention for Binge Eating & Weight-related Behaviors overallStatus: RECRUITING date: 2024-03-21 date: 2026-09-30 da... |
<|newrecord|> nctId: NCT06349447 id: KY2021-771 briefTitle: Pilot Study of LED for PIE and PIH overallStatus: RECRUITING date: 2024-04-10 date: 2024-05-10 date: 2024-06-01 date: 2024-04-05 date: 2024-04-05 name: Yanjun Dan class: OTHER briefSummary: The aim of this study is to explore the effect of medical LEDs (830 nm... |
<|newrecord|> nctId: NCT06349434 id: R-1215-23 briefTitle: The Utilization Effects of Powered Wearable Orthotics in Improving Upper Extremity Function and ADL in Persons With SCI overallStatus: RECRUITING date: 2023-10-15 date: 2028-10-01 date: 2028-10-01 date: 2024-04-05 date: 2024-04-15 name: Kessler Foundation class... |
<|newrecord|> nctId: NCT06349421 id: 202401078RINE briefTitle: Exploring the Impact of Fully Guided Implant Placement on Classifying Bone Quality Through Tactile Sensation overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2024-05-31 date: 2024-10-31 date: 2024-04-05 date: 2024-04-05 name: National Taiwan Univers... |
Technological advancements now enable the preoperative design of implant placement through a comprehensive guide, merging CBCT DICOM files with digital oral scanning data. This "fully guided" approach enhances the precision, stability, and safety of implant placement surgery. However, the use of a fully guided surgical... |
This study aims to assess the difference in bone quality evaluation by tactile sensation between freehand drilling and drilling with a fully guided surgical guide, using test blocks of different bone density. The discussion will explore the pros and cons of employing a fully guided guide to optimize outcomes in implant... |
<|newrecord|> nctId: NCT06349408 id: CIBI3001A101 briefTitle: IBI3001 in Participants With Unresectable, Locally Advanced or Metastatic Solid Tumors overallStatus: NOT_YET_RECRUITING date: 2024-05-30 date: 2026-05-30 date: 2027-05-30 date: 2024-04-05 date: 2024-04-05 name: Innovent Biologics (Suzhou) Co. Ltd. class: IN... |
<|newrecord|> nctId: NCT06349395 id: NisantasiU briefTitle: The Effect of Mindfulness-Based Stress Reduction Training Before Mastectomy on Postoperative Pain in Early Period overallStatus: RECRUITING date: 2023-05-01 date: 2024-06-29 date: 2024-07-29 date: 2024-04-05 date: 2024-04-05 name: Istanbul Nisantasi University... |
<|newrecord|> nctId: NCT06349382 id: CALAS briefTitle: CArbohydrate Loading in Aortic Surgery overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-10-01 date: 2024-11-01 date: 2024-04-05 date: 2024-04-08 name: University of Belgrade class: OTHER briefSummary: The adverse effects of overnight fasting before sur... |
<|newrecord|> nctId: NCT06349369 id: PG Thesis/2023-24/105 briefTitle: Effect of tDCS on Inflammatory Biomarkers in Chronic Schizophrenia acronym: tDCS overallStatus: RECRUITING date: 2024-04-08 date: 2025-12-09 date: 2026-04-09 date: 2024-04-05 date: 2024-04-25 name: All India Institute of Medical Sciences, Bhubaneswa... |
<|newrecord|> nctId: NCT06349356 id: FDACSTIM0012023 id: IRB00000533 type: OTHER domain: WCG IRB briefTitle: Prospective Evaluation of Efficacy and Safety of an Intense Pulsed Light Device to Treat Dry Eye Disease" overallStatus: RECRUITING date: 2023-03-28 date: 2024-09-30 date: 2024-12-31 date: 2024-04-05 date: 2024-... |
• Difference of the evolution of Tear Break-Up time (TBUT) between the 2 arms of the study (placebo and treated). |
Researchers will compare treated group and placebo to respond to the main question. |
Participants will assess to an inclusion visit (disease evaluation purpose) and then four IPL treatment visit to finish with the last visit (disease evaluation purpose). conditions: Dry Eye Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: MULT... |
<|newrecord|> nctId: NCT06349343 id: UHCT230949 briefTitle: CD19/BCMA HLA-independent TCR-T Cell Therapy for Refractory/Moderate-to-severe Systemic Lupus Erythematosus overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-01 date: 2026-01 date: 2024-04-05 date: 2024-04-05 name: Wuhan Union Hospital, China class: O... |
<|newrecord|> nctId: NCT06349330 id: 2022/00908 briefTitle: The Immediate Effectiveness of a 3D Intraoral Scanner as an Oral Hygiene Educational Tool acronym: 3D scanner overallStatus: RECRUITING date: 2023-11-07 date: 2024-07-31 date: 2024-07-31 date: 2024-04-05 date: 2024-04-24 name: National University Hospital, Sin... |
* Does a 3D intra-oral scanner facilitate the improvement of oral hygiene in subjects? |
* Does a 3D-rendered image of plaque-stained teeth confer better visualization to subjects? |
Prospective Open Cohort study: Patients referred to NUCOHS Periodontology Department will be invited to participate in the study. Included participants will be randomized into the 3D scanner (test) and standard oral hygiene (control) group. Subsequently, both groups will receive personalized oral hygiene instructions b... |
Routine periodontal parameters will be recorded at baseline and researchers will compare the percentage improvement in full mouth plaque scores to see if the test group performed better than the control group. |
A questionnaire will be given to subjects in the test and control group for qualitative analysis. |
The study will require 1 visit. conditions: Periodontal Diseases conditions: Plaque Induced Gingival Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is a parallel-arm randomized controlled trial and subjects are randomized into test and ... |
To investigate the immediate effectiveness on the use of 3D intraoral scanner in the improvement of oral hygiene in two (2) parallel arm study with 52 subjects (n=52). The study will take place over 1 visit. primaryPurpose: PREVENTION masking: SINGLE whoMasked: INVESTIGATOR count: 52 type: ESTIMATED name: Test: 3D intr... |
<|newrecord|> nctId: NCT06349317 id: 2024-005 briefTitle: Neoadjuvant IMRT Combined With Camrelizumab and Apatinib for Resectable HCC With PVTT overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-05 date: 2026-06 date: 2024-04-05 date: 2024-04-05 name: Yongyi Zeng class: OTHER briefSummary: This study is an open... |
<|newrecord|> nctId: NCT06349304 id: S25 briefTitle: Impact of Grape Powder Consumption on Eye Health and Glycemic Status in Singapore Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-08-01 date: 2025-08-01 date: 2024-04-05 date: 2024-04-05 name: National University of Singapore class: OTHER n... |
<|newrecord|> nctId: NCT06349291 id: 0074-24-MMC briefTitle: Venous Thrombosis After Removal of Central Venous Catheter overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2025-08-01 date: 2025-08-01 date: 2024-04-05 date: 2024-04-05 name: Meir Medical Center class: OTHER briefSummary: Insertion of intravenous cat... |
In this study, we aim to check the proportion of patients who developed thrombosis at the central catheter insertion sites after its removal, to check whether there are catheter insertion sites that are at a higher risk of developing thrombosis than other sites, and to check whether there are predictive characteristics... |
<|newrecord|> nctId: NCT06349278 id: 2024-7276 briefTitle: Pancreatic Cancer and Synchronous Liver Metastases Resection Following Neoadjuvant FOLFIRINOX acronym: PDAC-LIV overallStatus: RECRUITING date: 2024-01-16 date: 2026-01-16 date: 2029-01-16 date: 2024-04-05 date: 2024-04-16 name: Laval University class: OTHER br... |
<|newrecord|> nctId: NCT06349265 id: 02 briefTitle: Ultrasound-Guided 5% Dextrose Injection for Carpal Tunnel Syndrome overallStatus: COMPLETED date: 2023-10-02 date: 2024-02-02 date: 2024-03-02 date: 2024-04-05 date: 2024-04-05 name: Kastamonu University class: OTHER briefSummary: This study was a prospective randomiz... |
<|newrecord|> nctId: NCT06349252 id: LUNGTNM briefTitle: Survival Validation and Gene Mutations of N Descriptors in the Ninth Edition of the TNM Classification for Lung Cancer overallStatus: RECRUITING date: 2021-01-01 date: 2024-08-01 date: 2025-01-01 date: 2024-04-05 date: 2024-04-05 name: Fudan University class: OTH... |
<|newrecord|> nctId: NCT06349239 id: 24Hemato01 briefTitle: Oral Azacitidine Maintenance Post-CPX 351 acronym: ORAZ-351 overallStatus: RECRUITING date: 2020-01-01 date: 2025-01-01 date: 2025-01-01 date: 2024-04-05 date: 2024-04-05 name: Centre Hospitalier Universitaire de Nice class: OTHER briefSummary: Approximately 1... |
Although induction chemotherapy results in remission in many older patients with AML, relapse is common and overall survival is poor. For patients not eligible for HSCT, maintenance therapies are needed to reduce the risk of relapse and prolong overall survival without causing undue adverse effects or compromising heal... |
The use of oral azacitidine maintenance is an integral part of clinical practice for AML patients who have achieved a first complete remission (CR) or complete remission with incomplete blood count recovery (CRi) after intensive ""3+7"" induction chemotherapy and who are unable to complete intensive curative therapy. |
But there are few data on its efficacy as a post-CPX-351 maintenance agent in patients with newly diagnosed t-AML or AML-MRC or de novo AML.THe aim of this study is to show the improvement of overall survival with use of oral Azacitidine as maintenance for patients with de novo AML including t-AML or AML-MRC who achiev... |
<|newrecord|> nctId: NCT06349226 id: DISCOLAB briefTitle: Identification of Biomarkers and Molecular Targets Involved on Intervertebral Disc Degeneration and Discogenic Pain overallStatus: RECRUITING date: 2018-05-22 date: 2025-05-21 date: 2025-05-21 date: 2024-04-05 date: 2024-04-05 name: Fondazione IRCCS Ca' Granda, ... |
<|newrecord|> nctId: NCT06349213 id: C23-19 id: 2023-A02263-42 type: OTHER domain: Secondary ID briefTitle: Uncovering the Cognitive and Neural Mechanisms Underlying Cognitive Time acronym: TIMES overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2026-11-01 date: 2030-11-01 date: 2024-04-05 date: 2024-04-10 name:... |
<|newrecord|> nctId: NCT06349200 id: 3197 briefTitle: Comparing Binaural Beats and 432Hz Music for Reduction of Preoperative Anxiety in Root Canal Patients overallStatus: RECRUITING date: 2024-03-27 date: 2024-06 date: 2024-07 date: 2024-04-05 date: 2024-04-12 name: Dow University of Health Sciences class: OTHER briefS... |
<|newrecord|> nctId: NCT06349187 id: dsc002 briefTitle: Digital Competencies of the Doctors overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-05-10 date: 2024-06-10 date: 2024-04-05 date: 2024-04-05 name: Limited Liability Company "Docstarclub" class: OTHER briefSummary: The role of digital technologies in ... |
The most common methodologies for determining a doctor's digital literacy level are HITCOMP and TIGER. In particular, HITCOMP includes 5 areas of expertise: administration, research/biomedicine, direct patient care, computer science, engineering/information systems/information and communication technologies, as well as... |
However, in our opinion, the digital competence of a doctor is not only the ability to work at a computer and use software. The successful development of the digital world is preceded by some psychological and emotional processes. |
It all starts with digital trust, that is, with people's confidence in the reliability and security of digital systems, processes and technologies. Without the conviction that the implementation and active use of certain IT services will be useful and will not bring harm, the successful launch of such technologies will... |
Provided that there is digital trust, a person in his daily life gradually gets experience using various technologies: payments, appointments with specialists, purchases, etc. Thus, basic digital literacy appears in conjunction with the rules of behavior in the online space (digital culture). And only after that, havin... |
Computerization and automation of the healthcare system began relatively recently, traditional (paper) document management in medicine is familiar to everyone, but not optimal from the point of view of system management. Therefore, universal digitalization is perceived as something artificially imposed, increasing the ... |
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