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And the final stage, having gained the opportunity to overcome internal obstacles, the doctor is ready to begin mastering specialized digital skills directly related to medical activities: work in medical information systems, remote monitoring, artificial intelligence, medical decision support systems. |
The result of the development of a doctor within this model will be not only digital literacy, but also the development of an internally stable personality that easily overcomes any obstacles not only in training, but also in communication with patients and colleagues. conditions: Digital Competences conditions: Emotio... |
<|newrecord|> nctId: NCT06349174 id: 2024-valve-1 briefTitle: Safety and Efficacy of Endobronchial Valve for Bronchoscopic Lung Volume Reduction Surgery: A Prospective Pilot Study overallStatus: NOT_YET_RECRUITING date: 2024-04-11 date: 2025-03-20 date: 2025-03-31 date: 2024-04-05 date: 2024-04-05 name: China-Japan Fri... |
Does self-devloped endobronchial valves improve the lung function、exercise capacity and symptons of participants? What surgery-related adverse events do participants have after transbronchial lung volume reduction surgery using the self-devloped endobronchial valves? |
Participants will: |
undergo transbronchial lung volume reduction surgery using the self-devloped endobronchial valves. |
receive follow-up before surgery (baseline) and 3 days, 4 weeks, 12weeks after surgery. conditions: Emphysema conditions: Chronic Obstructive Pulmonary Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: bron... |
<|newrecord|> nctId: NCT06349161 id: 1451_02/BVNTW-VNCSKTE briefTitle: Long-term Outcome of Retroperitoneoscopic One-trocar-assisted Pyeloplasty: A Single-center and Single-surgeon Experience overallStatus: COMPLETED date: 2011-05 date: 2013-06 date: 2024-03 date: 2024-04-05 date: 2024-04-05 name: National Children's H... |
<|newrecord|> nctId: NCT06349148 id: NESTLE2022QN-0007 briefTitle: The Effects of Immunonutrition Therapy on Locally Advanced Cervical Cancer Patients overallStatus: RECRUITING date: 2024-01-01 date: 2025-08 date: 2025-12 date: 2024-04-05 date: 2024-04-05 name: SHUANGZHENGJIA class: OTHER briefSummary: The goal of this... |
<|newrecord|> nctId: NCT06349135 id: A.Ayman OMFS briefTitle: Assessment of Serum Concentration of Interleukin-17 and Osteoprotegerin in Response to Surgical Trauma Induced by Management of Mandibular Fractures Via Intraoral Versus Extraoral Approaches: Prospective Cohort Study overallStatus: NOT_YET_RECRUITING date: 2... |
<|newrecord|> nctId: NCT06349122 id: 2023-509421-41-00 briefTitle: Screen-and-treat Strategy for Vaginal Flora Abnormalities in Pregnant Women at High Risk of Preterm Birth acronym: AUTOP2 overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2027-03 date: 2028-01 date: 2024-04-05 date: 2024-04-05 name: Assistance Publ... |
The main objective of the study is to evaluate the effectiveness of an innovative screen-and-treat strategy for vaginal flora abnormalities by molecular biology using a Point of Care multiplex technology before 18 weeks' gestation to reduce the rate of preterm birth in a population of pregnant women at high risk of pre... |
The hypothesis is that a strategy for screening and treating vaginal flora abnormalities and their recurrences using molecular biology in women with a history of prematurity or late-term abortion could be effective in reducing premature births by 40%. conditions: Bacterial Vaginosis conditions: Vaginal Dysbiosis condit... |
<|newrecord|> nctId: NCT06349109 id: PA-WPW briefTitle: Physical Activity in Children With Wolff-Parkinson-White Syndrome overallStatus: RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-05-01 date: 2024-04-05 date: 2024-04-09 name: Karamanoğlu Mehmetbey University class: OTHER briefSummary: The aim of this study... |
<|newrecord|> nctId: NCT06349096 id: ALM-HAR-CLL-23-01 briefTitle: Safety And Efficacy Investigation Of The Effects Of ClearLift Q-Switched Nd:Yag 1064nm Laser Module In The Treatment Of Facial Skin Wrinkles overallStatus: NOT_YET_RECRUITING date: 2024-03-26 date: 2024-10 date: 2024-10 date: 2024-04-05 date: 2024-04-05... |
Based on this background, we have considered an interest to design a study aimed at assessing the efficacy and safety of a treatment course with ClearLift Module in patients with facial skin wrinkles conditions: Facial Skin Wrinkles studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP pri... |
<|newrecord|> nctId: NCT06349083 id: 23-01227 briefTitle: Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2029-01 date: 2029-01 date: 2024-04-05 date: 2024-04-05 name: NYU Langone Health class: OTHER name: National Institute on Alcohol Abuse and ... |
<|newrecord|> nctId: NCT06349070 id: 23-00404 briefTitle: RESTORE - Phase II overallStatus: RECRUITING date: 2024-01-26 date: 2027-01-30 date: 2027-03-30 date: 2024-04-05 date: 2024-04-05 name: NYU Langone Health class: OTHER name: National Heart, Lung, and Blood Institute (NHLBI) briefSummary: The study will apply the... |
<|newrecord|> nctId: NCT06349057 id: AnkaraCHBilkent.1 briefTitle: The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery overallStatus: RECRUITING date: 2024-01-01 date: 2024-12-01 date: 2024-12-30 date: 2024-04-05 date: 2024-04-05 name: Ankara City Hospital Bilkent class: OTHER briefSumma... |
In this study, the anticholinergic burden of the patients in the perioperative period will be calculated with the Anticholinergic Cognitive Burden Scale (ACBS) and patients with a score of 1 or above will be included in the study. Anticholinergic load of drugs used in the intraoperative period; Its effect on postoperat... |
<|newrecord|> nctId: NCT06349044 id: BASIMA briefTitle: A Randomized, Multicenter Phase II Basket Study of Hypofractionated Radiotherapy/Stereotactic Body Radiotherapy Followed by Immunotherapy-Based Systemic Therapy +/- L. Rhamnosus M9 for the First-Line Treatment of Advanced Digestive System Malignancies. overallStat... |
<|newrecord|> nctId: NCT06349031 id: IEC/IMS.SH/SOA/2024/683 briefTitle: Comparison of Efficacy & Tolerability Of PEG 4000 Versus PEG 3350+ Electrolytes for Pediatric Fecal Disimpaction overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-09-15 date: 2024-09-15 date: 2024-04-05 date: 2024-04-12 name: Institute... |
Polyethylene glycol (PEG) based laxatives have been recommended as the first-line therapeutic agents. The commonly used formulations are PEG 3350 with a molecular weight between 3200- 3700 g/mol and PEG 4000 with molecular weight of 4000 g/mol. Both are shown to be effective in pediatric constipation management in plac... |
Present study has been planned to evaluate the efficacy \& tolerability of PEG 4000 versus PEG 3350+ E for fecal disimpaction in pediatric functional constipation. Patients between age 1-16 years having functional constipation (as per ROME IV criteria) with fecal impaction will be included. Subjects will be randomly as... |
Primary outcome is defined as the proportion of subjects achieving fecal disimpaction in each arm. |
Secondary outcomes are defined as follows: |
1. Total no of Days required to achieve fecal disimpaction in each arm |
2. Cumulative dose of PEG required for fecal disimpaction in each arm |
3. Proportion of subjects (\> 5 years age) reporting palatability issues in each arm |
4. Proportion of subjects discontinuing the treatment due to palatability issues in each arm conditions: Functional Constipation conditions: Fecal Impaction conditions: Constipation - Functional conditions: Constipation Chronic Idiopathic conditions: Pediatric Functional Constipation studyType: INTERVENTIONAL phases: P... |
<|newrecord|> nctId: NCT06349018 id: IRB-2023-972 briefTitle: Effects of Isotonic Beetroot Supplementation on Sprint Interval Exercise Performance overallStatus: RECRUITING date: 2024-02-20 date: 2025-02-28 date: 2025-02-28 date: 2024-04-05 date: 2024-04-09 name: Nanyang Technological University class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06349005 id: 111 briefTitle: Laryngoscopy and Coronary Artery Bypass Graft Surgery acronym: VL overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-08-01 date: 2024-09-01 date: 2024-04-05 date: 2024-04-05 name: Konya Meram State Hospital class: OTHER briefSummary: In this prospective, r... |
<|newrecord|> nctId: NCT06348992 id: HMUDQ20240318001 briefTitle: ACT Combined Yoga for Parental Burnout in Parents With Autistic Children overallStatus: RECRUITING date: 2023-09-01 date: 2024-12-31 date: 2024-12-31 date: 2024-04-05 date: 2024-04-05 name: Harbin Medical University class: OTHER briefSummary: OBJECTIVE: ... |
METHODS: This study used a combination of qualitative research and quantitative analysis to examine the intervention effects of an ACT-centered intervention program on parenting burnout in parents of children with ASD, and to clarify the evaluations and perceptions of parents with ASD about the research program through... |
RESULTS AND CONCLUSION: To clarify the intervention effect of ACT combined with yoga intervention program on parenting burnout of ASD parents. conditions: Autism Spectrum Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoM... |
<|newrecord|> nctId: NCT06348979 id: CEBD 5/2021 briefTitle: Clinical Performance of Fiber Reinforced FRC Base and Bonded CAD/CAM Resin Composite Endocrowns overallStatus: COMPLETED date: 2022-01-01 date: 2023-12-30 date: 2024-01-30 date: 2024-04-05 date: 2024-04-05 name: Cairo University class: OTHER briefSummary: Thi... |
<|newrecord|> nctId: NCT06348966 id: predictors of readmission briefTitle: Predictors of Hospital Readmission for Chronic Obstructive Pulmonary Disease Patients overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05 date: 2026-06 date: 2024-04-05 date: 2024-04-05 name: Assiut University class: OTHER briefSumm... |
<|newrecord|> nctId: NCT06348953 id: Bioactive restorative system briefTitle: Bioactive Versus Non-Bioactive Restorative System in Deep Carious Molars overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-11 date: 2025-11 date: 2024-04-05 date: 2024-04-09 name: Cairo University class: OTHER briefSummary: This rese... |
<|newrecord|> nctId: NCT06348940 id: 83242392 briefTitle: Effects of Behavioral Activation on Negative Emotions, Cancer-related Symptoms and Clinical Indicators in Cancer Patients overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-12 date: 2024-06-12 date: 2024-06-12 date: 2024-04-05 date: 2024-04-08 name: Anhui Medica... |
The investigators aimed to recruit a total of 390 cancer patients, comprising 170 individuals diagnosed with esophageal and gastric cancer, 100 individuals with colorectal cancer, and 120 individuals with lung cancer. These patients were recruited from the Department of Oncology at the Second Affiliated Hospital of Anh... |
This study aims to demonstrate the significant efficacy of behavioral activation in improving negative emotions, somatic symptoms, quality of life, and clinical inflammatory indicators among cancer patients. Furthermore, it may potentially enhance patient survival rates, thereby offering a novel approach for psychologi... |
The investigators have implemented a questionnaire system on the WJX website (https://www.wjx.cn/) to collect patient information through both paper and electronic questionnaires. The psychological measurement questionnaires are stored electronically, while socio-demographic data and clinical indicators are collected i... |
Possible statistical methods include descriptive statistical analysis, generalized estimating equation or repeated measures analysis of variance, structural equation modeling, correlation analysis and regression, survival analysis, etc. conditions: Cancer Patients studyType: INTERVENTIONAL phases: NA allocation: RANDOM... |
<|newrecord|> nctId: NCT06348927 id: DZ2023EI004 briefTitle: Sunvozertinib Plus Anlotinib as 1L Treatment in EGFR-Sensitive Mutations Combined With Co-Mutations Advanced NSCLC acronym: WUKONG-32 overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2025-10-31 date: 2027-04-30 date: 2024-04-05 date: 2024-04-05 name: ... |
Condition or disease Intervention/treatment Phase Non-Small Cell Lung Cancer Drug: sunvozertinib Drug: anlotinib Phase 2 conditions: Non-Small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 52 type: ESTIMATED name: ... |
<|newrecord|> nctId: NCT06348914 id: 6991 briefTitle: Knowledge of Vital Pulp Therapy in Permanent Teeth Among a Group of Dental Students in Egypt overallStatus: NOT_YET_RECRUITING date: 2024-09-10 date: 2024-11-10 date: 2024-12-30 date: 2024-04-05 date: 2024-04-05 name: Cairo University class: OTHER briefSummary: Cond... |
<|newrecord|> nctId: NCT06348901 id: 2021-09-001 briefTitle: Clinical Utility of Oxford Cognitive Screen Test to Screen Cognitive Impairment in Post Stroke Patients overallStatus: RECRUITING date: 2021-09-01 date: 2025-02-28 date: 2025-02-28 date: 2024-04-05 date: 2024-04-05 name: Bundang CHA Hospital class: OTHER brie... |
validate the reliability and validity of the Korean version of the Oxford Cognitive Screen (K-OCS) analyze its sensitivity, specificity, and diagnostic accuracy, and compare its examination participation rates with existing assessment tools to determine the effectiveness of K-OCS in detecting post-stroke cognitive impa... |
<|newrecord|> nctId: NCT06348888 id: 22250 briefTitle: A Study to Learn About How Itraconazole and Carbamazepine Affect the Level of BAY2927088 in the Blood When These Drugs Are Taken Together by Healthy Participants overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-05-30 date: 2024-05-30 date: 2024-04-05 d... |
Advanced NSCLC refers to a type of lung cancer that has spread from the lungs to nearby tissues or other body parts. People with advanced NSCLC may have changes in certain proteins like EGFR and HER2, that cause uncontrolled cell growth and increased spread of cancer. |
In this study, participants will be healthy and will not benefit from taking the study treatment, BAY2927088. However, the study will provide information about how to test BAY2927088 in future studies with people who have advanced NSCLC with EGFR or HER2 mutations. |
BAY2927088 is under development for the treatment of advanced NSCLC with EGFR or HER2 mutations. It is expected to work against these changed proteins, which might slow down the spread of cancer. |
BAY2927088 is broken down by an enzyme called CYP3A4 inside the body. Itraconazole is a drug that inhibits the activity of CYP3A4 while carbamazepine is a drug that enhances the activity of CYP3A4. Giving these drugs together will allow researchers to learn how the blood levels of BAY2927088 change when the CYP3A4 acti... |
The main purpose of this study is to find out how itraconazole and carbamazepine may affect the blood levels of BAY2927088. For this, researchers will measure the following for BAY2927088 when it is given with and without itraconazole and carbamazepine |
* Area under the curve (AUC): a measure of the total amount of BAY2927088 in participants' blood over time |
* Maximum observed concentration (Cmax): the highest amount of BAY2927088 in participants' blood |
The study will have 2 treatment groups. |
In Group 1, participants will take: |
* BAY2927088 as a single dose on Days 1 and 8. |
* Itraconazole once daily on Days 5 to 11. |
In Group 2, participants will take: |
* BAY2927088 as a single dose on Days 1 and 14. |
* Different doses of carbamazepine two times a day on Days 3 to 15. Participants will be in this study for about 7 weeks in Group 1 and 8 weeks in Group 2. |
Participants will visit the study clinic: |
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