harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa.	[ [ "L-dopa", "unintended sleep episodes" ] ]
These findings are consistent with an immune-complex form of glomerulopathy in which gold is neither the antigen nor a hapten in the glomerular deposits, and they suggest the hypothesis that antibodies to tubular epithelial antigens induced by gold therapy may be a causative factor in the renal disease associated with gold therapy in rheumatoid arthritis.	[ [ "gold", "renal disease" ] ]
Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.	[ [ "risperidone", "periods of crying" ], [ "risperidone", "depression" ], [ "risperidone", "feelings of agitation" ], [ "risperidone", "insomnia" ], [ "risperidone", "intolerable affect" ] ]
Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgaris.	[ [ "prednisone", "Disseminated cellulitic cryptococcosis" ] ]
Focal glomerulonephritis and interstitial nephritis in methicillin-treated, heroin-related infective endocarditis.	[ [ "methicillin", "interstitial nephritis" ], [ "methicillin", "Focal glomerulonephritis" ] ]
Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital.	[ [ "Oxcarbazepine", "angioedema" ] ]
We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.	[ [ "metaraminol", "anaphylaxis" ] ]
We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone.	[ [ "ibuprofen", "depressed level of consciousness" ] ]
However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.	[ [ "thalidomide", "neuropathic side effects" ] ]
Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.	[ [ "carbamazepine", "Deposits of plasma proteins in the skin" ], [ "diphenylhydantoin", "Deposits of plasma proteins in the skin" ] ]
Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.	[ [ "valproic acid", "dementia" ] ]
We report a case of a patient with rheumatoid arthritis treated with low-dose methotrexate (15 mg/week) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip.	[ [ "methotrexate", "infection with both M. tuberculosis and M. chelonae" ] ]
We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures.	[ [ "carbamazepine", "antidiuresis" ] ]
This case report describes a 38-year-old male in whom SIADH was strongly suspected secondary to Tegretol therapy to control a seizure disorder.	[ [ "Tegretol", "SIADH" ] ]
This article describes a patient with suspected ciprofloxacin-induced interstitial nephritis.	[ [ "ciprofloxacin", "interstitial nephritis" ] ]
We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.	[ [ "cyclophosphamide", "systemic candidiasis" ] ]
Concomitant irradiation apparently enhanced the skin toxicity of aminoglutethimide or possibly aminoglutethimide had a radiosensitizing role in this patient.	[ [ "aminoglutethimide", "skin toxicity" ] ]
We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.	[ [ "doxetaxel", "glaucoma" ] ]
The first patient was a 61-year-old man with a 30-year history of fistulizing CD in whom B-cell non-Hodgkin's lymphoma was diagnosed 9 months after treatment with infliximab.	[ [ "infliximab", "B-cell non-Hodgkin's lymphoma" ] ]
He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy.	[ [ "licorice", "hypokalemia" ] ]
A few recent individual case reports have suggested that a myasthenic syndrome may be associated with statin treatment, but this association is not well described.	[ [ "statin", "myasthenic syndrome" ] ]
According to the Naranjo probability scale, the relationship of gemcitabine treatment with cutaneous eruption in our patient is possible.	[ [ "gemcitabine", "cutaneous eruption" ] ]
This article reports the occurrence of rifampin-associated thrombocytopenia in an indigent patient after a four-month lapse in therapy for pulmonary tuberculosis.	[ [ "rifampin", "thrombocytopenia" ] ]
Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.	[ [ "tamoxifen", "malignant transformation of endometriosis" ] ]
Occurrence of IDDM during interferon therapy for chronic viral hepatitis.	[ [ "interferon", "IDDM" ] ]
Fluorouracil for allergic reactions to capecitabine.	[ [ "capecitabine", "allergic reactions" ] ]
The aim of this report is to describe the clinical and electroencephalographic findings seen in an elderly woman without previous history of seizures who developed a nonconvulsive generalized status epilepticus following acute withdrawal of lorazepam.	[ [ "lorazepam", "nonconvulsive generalized status epilepticus" ] ]
Allopurinol hypersensitivity.	[ [ "Allopurinol", "hypersensitivity" ] ]
Transtubular potassium gradient (TTKG) also decreased and an inverse correlation was found between TTKG and doses of phosphate (r = -0.37; p < 0.02; N = 38).	[ [ "phosphate", "Transtubular potassium gradient (TTKG) also decreased" ] ]
OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.	[ [ "valproate", "reproductive endocrine disorders" ] ]
High-grade atrioventricular block during dipyridamole stress testing.	[ [ "dipyridamole", "High-grade atrioventricular block" ] ]
Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.	[ [ "methylprednisolone", "Acute myocardial infarction" ] ]
Captopril-related (and -induced?) asthma.	[ [ "Captopril", "asthma" ] ]
Epsilon-aminocaproic acid and renal complications: case report and review of the literature.	[ [ "Epsilon-aminocaproic acid", "renal complications" ] ]
We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.	[ [ "BH-AC", "encephalopathy syndrome" ], [ "idarubicin", "encephalopathy syndrome" ] ]
CONCLUSIONS: We conclude that a high dose combined with a short infusion time increases the risk of anaphylactoid reactions with the administration of intraperitoneal cisplatin.	[ [ "cisplatin", "anaphylactoid reactions" ] ]
Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.	[ [ "garenoxacin", "Torsades de Pointes" ], [ "disopyramide", "Torsades de Pointes" ] ]
NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.	[ [ "ifosfamide", "NCSE" ] ]
Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.	[ [ "lithium", "Brugada type electrocardiographic changes" ], [ "propafenone", "Brugada type electrocardiographic changes" ] ]
Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia.	[ [ "imatinib mesylate", "Kaposi's sarcoma" ] ]
Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.	[ [ "Zidovudine", "birth defects" ] ]
Late lethal hepatitis B virus reactivation after rituximab treatment of low-grade cutaneous B-cell lymphoma.	[ [ "rituximab", "hepatitis B virus reactivation" ] ]
Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.	[ [ "clomipramine", "extrapyramidal symptoms" ], [ "clomipramine", "Seizures" ], [ "interferon beta-1a", "extrapyramidal symptoms" ], [ "interferon beta-1a", "Seizures" ] ]
Three patients developed proteinuria following gold therapy for rheumatoid arthritis.	[ [ "gold", "proteinuria" ] ]
We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.	[ [ "Warfarin", "stuttering" ], [ "Warfarin", "priapism" ] ]
In addition to the recognized arrhythmic complications, the authors emphasize myocardial necrosis as a possible further manifestation of amsacrine-related cardiotoxicity.	[ [ "amsacrine", "cardiotoxicity" ], [ "amsacrine", "myocardial necrosis" ] ]
Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy.	[ [ "hydroxychloroquine", "nephrosis" ] ]
A short review on imatinib-related hepatotoxicity is also presented.	[ [ "imatinib", "hepatotoxicity" ] ]
The authors report a further case of methimazole-associated liver damage and present a brief review of eleven previous cases found in the literature.	[ [ "methimazole", "liver damage" ] ]
The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.	[ [ "gold", "skin disturbances" ] ]
Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.	[ [ "cyproterone acetate", "Avascular necrosis of the femoral head" ] ]
PURPOSE: To describe transient structured visual hallucinations in a patient with vascular age-related macular degeneration (AMD), following an intravitreal Avastin-injection.	[ [ "Avastin", "transient structured visual hallucinations" ] ]
The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.	[ [ "insulin", "angioedema" ], [ "insulin", "urticaria" ], [ "NPH", "angioedema" ], [ "NPH", "urticaria" ] ]
We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.	[ [ "busulfan", "severe interstitial lung fibrosis" ], [ "melphalan", "severe interstitial lung fibrosis" ] ]
However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued.	[ [ "prednisone", "Cushingoid features" ] ]
We present the case of a 58-year-old woman who ingested more than 35 g of caffeine in a suicide attempt.	[ [ "caffeine", "suicide attempt" ] ]
Renal tubular acidosis secondary to FK506 in living donor liver transplantation: a case report.	[ [ "FK506", "Renal tubular acidosis" ] ]
The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.	[ [ "methotrexate", "nodules" ] ]
The possibility of severe rhabdomyolysis should be considered in a patient with water intoxication due to massive ingestion of caffeine-containing beverages.	[ [ "caffeine", "rhabdomyolysis" ], [ "caffeine", "water intoxication" ] ]
Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.	[ [ "flutamide", "decrease in prostate-specific antigen" ], [ "Flutamide", "Flutamide withdrawal syndrome" ], [ "flutamide", "Flutamide withdrawal syndrome" ], [ "Flutamide", "decrease in prostate-specific antigen" ] ]
Although it is difficult to be certain of the direct link of amiodarone on the basis of a single case, it is reasonable to presume that this histopathology is associated with amiodarone-induced hypothyroidism and that involution changes represent the hypofunctional status of this drug-induced disorder.	[ [ "amiodarone", "hypothyroidism" ] ]
The literature search found 12 cases of radiation recall caused by gemcitabine.	[ [ "gemcitabine", "radiation recall" ] ]
Cholestyramine induced hyperchloremic metabolic acidosis.	[ [ "Cholestyramine", "hyperchloremic metabolic acidosis" ] ]
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.	[ [ "sulfamethoxazole", "symptomatic hypoglycemia" ], [ "glipizide", "symptomatic hypoglycemia" ], [ "trimethoprim", "symptomatic hypoglycemia" ], [ "TMP", "symptomatic hypoglycemia" ], [ "SMX", "symptomatic hypoglycemia" ] ]
Cardiopulmonary arrest following intravenous phenytoin loading.	[ [ "phenytoin", "Cardiopulmonary arrest" ] ]
Atenolol-induced pseudolymphoma.	[ [ "Atenolol", "pseudolymphoma" ] ]
Myoclonus associated with continuous dobutamine infusion in a patient with end-stage renal disease.	[ [ "dobutamine", "Myoclonus" ] ]
A 2-year-old mentally retarded boy with frontal lobe epilepsy presented with an episode that resembled heat stroke during the administration of zonisamide.	[ [ "zonisamide", "heat stroke" ] ]
Mequitazine seemed to play a part similar to chlorpromazine, and absence of mequitazine-induced photosensitivity may be due to a relatively low dosage of the drug.	[ [ "mequitazine", "photosensitivity" ] ]
Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.	[ [ "lenalidomide", "aplastic anemia" ] ]
A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.	[ [ "phenytoin", "erythroderma" ], [ "phenytoin", "pinhead-sized facial pustules" ], [ "phenytoin", "abnormal liver function tests" ], [ "phenytoin", "phenytoin hypersensitivity syndrome" ], [ "phenytoin", "tibial and facial oedema" ], [ "phenytoin", "fever" ] ]
BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.	[ [ "clozapine", "granulocytopenia" ] ]
Exfoliative dermatitis secondary to tobramycin sulfate.	[ [ "tobramycin sulfate", "Exfoliative dermatitis" ] ]
We describe a case of fibrosing alveolitis, diagnosed by lung biopsy, in a patient receiving amiodarone which responded to corticosteroid therapy.	[ [ "amiodarone", "fibrosing alveolitis" ] ]
Chronic fentanyl application induces adrenocortical insufficiency.	[ [ "fentanyl", "adrenocortical insufficiency" ] ]
Papillary necrosis associated with the HIV protease inhibitor indinavir.	[ [ "indinavir", "Papillary necrosis" ] ]
Acute interstitial nephritis due to pantoprazole.	[ [ "pantoprazole", "Acute interstitial nephritis" ] ]
Amiodarone is well recognized as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction.	[ [ "Amiodarone", "thyroid dysfunction" ] ]
Progressive pulmonary fibrosis complicating cyclophosphamide therapy.	[ [ "cyclophosphamide", "Progressive pulmonary fibrosis" ] ]
Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.	[ [ "IFN-beta", "inflammatory arthritis" ] ]
The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).	[ [ "methotrexate", "elevated liver transaminases" ], [ "methotrexate", "mild pruritus" ], [ "methotrexate", "mild neutropenia" ], [ "methotrexate", "bone pain" ], [ "methotrexate", "abdominal pain" ], [ "methotrexate", "nausea" ] ]
A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.	[ [ "CBZ", "tics" ], [ "CBZ", "movement disorders" ], [ "carbamazepine", "tics" ], [ "carbamazepine", "movement disorders" ] ]
CONCLUSIONS: Colchicine-induced myopathy should be excluded in patients with FMF who present with generalized muscle weakness.	[ [ "Colchicine", "myopathy" ] ]
During the first days of arsenic trioxide treatment a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes.	[ [ "arsenic trioxide", "decrease in the D-dimers" ], [ "arsenic trioxide", "slight decrease in peripheral blood leukocytes" ] ]
We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.	[ [ "cibenzoline", "blurred vision" ], [ "cibenzoline", "cibenzoline intoxication" ], [ "cibenzoline", "cardiac failure" ], [ "cibenzoline", "QRS broadening" ] ]
Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.	[ [ "clofazimine", "onycholysis" ], [ "clofazimine", "discoloration of nail plate" ], [ "clofazimine", "subungual hyperkeratosis" ] ]
Decreased plasma cortisol level during alprazolam treatment of panic disorder: a case report.	[ [ "alprazolam", "Decreased plasma cortisol level" ] ]
PURPOSE: To present a case of respiratory depression following the administration of nebulised morphine.	[ [ "morphine", "respiratory depression" ] ]
The harlequin color change and association with prostaglandin E1.	[ [ "prostaglandin E1", "harlequin color change" ] ]
Interstitial granulomatous dermatitis associated with darifenacin.	[ [ "darifenacin", "Interstitial granulomatous dermatitis" ] ]
The authors intend to carry out a case-control study on patients treated with tamoxifen for breast carcinoma to reveal the possible presence of endometrial carcinoma.	[ [ "tamoxifen", "endometrial carcinoma" ] ]
The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.	[ [ "valproate", "amenorrhea" ], [ "valproate", "gained weight" ], [ "valproate", "polycystic changes" ] ]
A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.	[ [ "phenobarbital", "icterus" ], [ "phenobarbital", "protein-losing enteropathy" ], [ "phenobarbital", "hypersensitivity" ], [ "phenobarbital", "alopecia" ], [ "phenobarbital", "a pruritic desquamating erythrodermic rash" ], [ "phenobarbital", "fever" ], [ "phenobarbital", "nephritis" ], [ "phenobarbital", "myositis" ] ]
Leflunomide-associated weight loss in rheumatoid arthritis.	[ [ "Leflunomide", "weight loss" ] ]
Diazepam use by pregnant women can be associated with a later presentation of withdrawal symptoms in the neonate than that induced by the use of other drugs.	[ [ "Diazepam", "withdrawal symptoms" ] ]
CASES: "A" was an 8-year-old boy with attention deficit and chronic tic disorder who developed obsessive-compulsive symptoms within 2 weeks of starting risperidone.	[ [ "risperidone", "obsessive-compulsive symptoms" ] ]
A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.	[ [ "Tegretol", "systemic lupus erythematosus (SLE)-like symptoms" ], [ "Tegretol", "leukopenia" ], [ "carbamazepine", "systemic lupus erythematosus (SLE)-like symptoms" ], [ "CBZ", "fever" ], [ "carbamazepine", "leukopenia" ], [ "CBZ", "rash" ], [ "CBZ", "positive anti-nuclear antibody" ], [ "CBZ", "leukopenia" ], [ "CBZ", "systemic lupus erythematosus (SLE)-like symptoms" ], [ "Tegretol", "fever" ], [ "carbamazepine", "rash" ], [ "Tegretol", "rash" ], [ "carbamazepine", "fever" ], [ "carbamazepine", "positive anti-nuclear antibody" ], [ "Tegretol", "positive anti-nuclear antibody" ] ]
PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.	[ [ "interferon alpha", "bilateral optic neuritis" ] ]
We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril.	[ [ "captopril", "pemphigus" ] ]
This is a report of a case of anuric ARF after high-dose mannitol infusion for treatment of narrow-angle glaucoma that readily responded to acute hemodialysis.	[ [ "mannitol", "anuric ARF" ] ]

A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa.

[ [ "L-dopa", "unintended sleep episodes" ] ]

These findings are consistent with an immune-complex form of glomerulopathy in which gold is neither the antigen nor a hapten in the glomerular deposits, and they suggest the hypothesis that antibodies to tubular epithelial antigens induced by gold therapy may be a causative factor in the renal disease associated with gold therapy in rheumatoid arthritis.

[ [ "gold", "renal disease" ] ]

Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.

[ [ "risperidone", "periods of crying" ], [ "risperidone", "depression" ], [ "risperidone", "feelings of agitation" ], [ "risperidone", "insomnia" ], [ "risperidone", "intolerable affect" ] ]

Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgaris.

[ [ "prednisone", "Disseminated cellulitic cryptococcosis" ] ]

Focal glomerulonephritis and interstitial nephritis in methicillin-treated, heroin-related infective endocarditis.

[ [ "methicillin", "interstitial nephritis" ], [ "methicillin", "Focal glomerulonephritis" ] ]

Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital.

[ [ "Oxcarbazepine", "angioedema" ] ]

We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.

[ [ "metaraminol", "anaphylaxis" ] ]

We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone.

[ [ "ibuprofen", "depressed level of consciousness" ] ]

However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.

[ [ "thalidomide", "neuropathic side effects" ] ]

Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.

[ [ "carbamazepine", "Deposits of plasma proteins in the skin" ], [ "diphenylhydantoin", "Deposits of plasma proteins in the skin" ] ]

Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.

[ [ "valproic acid", "dementia" ] ]

We report a case of a patient with rheumatoid arthritis treated with low-dose methotrexate (15 mg/week) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip.

[ [ "methotrexate", "infection with both M. tuberculosis and M. chelonae" ] ]

We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures.

[ [ "carbamazepine", "antidiuresis" ] ]

This case report describes a 38-year-old male in whom SIADH was strongly suspected secondary to Tegretol therapy to control a seizure disorder.

[ [ "Tegretol", "SIADH" ] ]

This article describes a patient with suspected ciprofloxacin-induced interstitial nephritis.

[ [ "ciprofloxacin", "interstitial nephritis" ] ]

We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.

[ [ "cyclophosphamide", "systemic candidiasis" ] ]

Concomitant irradiation apparently enhanced the skin toxicity of aminoglutethimide or possibly aminoglutethimide had a radiosensitizing role in this patient.

[ [ "aminoglutethimide", "skin toxicity" ] ]

We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.

[ [ "doxetaxel", "glaucoma" ] ]

The first patient was a 61-year-old man with a 30-year history of fistulizing CD in whom B-cell non-Hodgkin's lymphoma was diagnosed 9 months after treatment with infliximab.

[ [ "infliximab", "B-cell non-Hodgkin's lymphoma" ] ]

He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy.

[ [ "licorice", "hypokalemia" ] ]

A few recent individual case reports have suggested that a myasthenic syndrome may be associated with statin treatment, but this association is not well described.

[ [ "statin", "myasthenic syndrome" ] ]

According to the Naranjo probability scale, the relationship of gemcitabine treatment with cutaneous eruption in our patient is possible.

[ [ "gemcitabine", "cutaneous eruption" ] ]

This article reports the occurrence of rifampin-associated thrombocytopenia in an indigent patient after a four-month lapse in therapy for pulmonary tuberculosis.

[ [ "rifampin", "thrombocytopenia" ] ]

Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.

[ [ "tamoxifen", "malignant transformation of endometriosis" ] ]

Occurrence of IDDM during interferon therapy for chronic viral hepatitis.

[ [ "interferon", "IDDM" ] ]

Fluorouracil for allergic reactions to capecitabine.

[ [ "capecitabine", "allergic reactions" ] ]

The aim of this report is to describe the clinical and electroencephalographic findings seen in an elderly woman without previous history of seizures who developed a nonconvulsive generalized status epilepticus following acute withdrawal of lorazepam.

[ [ "lorazepam", "nonconvulsive generalized status epilepticus" ] ]

Allopurinol hypersensitivity.

[ [ "Allopurinol", "hypersensitivity" ] ]

Transtubular potassium gradient (TTKG) also decreased and an inverse correlation was found between TTKG and doses of phosphate (r = -0.37; p < 0.02; N = 38).

[ [ "phosphate", "Transtubular potassium gradient (TTKG) also decreased" ] ]

OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.

[ [ "valproate", "reproductive endocrine disorders" ] ]

High-grade atrioventricular block during dipyridamole stress testing.

[ [ "dipyridamole", "High-grade atrioventricular block" ] ]

Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.

[ [ "methylprednisolone", "Acute myocardial infarction" ] ]

Captopril-related (and -induced?) asthma.

[ [ "Captopril", "asthma" ] ]

Epsilon-aminocaproic acid and renal complications: case report and review of the literature.

[ [ "Epsilon-aminocaproic acid", "renal complications" ] ]

We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.

[ [ "BH-AC", "encephalopathy syndrome" ], [ "idarubicin", "encephalopathy syndrome" ] ]

CONCLUSIONS: We conclude that a high dose combined with a short infusion time increases the risk of anaphylactoid reactions with the administration of intraperitoneal cisplatin.

[ [ "cisplatin", "anaphylactoid reactions" ] ]

Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.

[ [ "garenoxacin", "Torsades de Pointes" ], [ "disopyramide", "Torsades de Pointes" ] ]

NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.

[ [ "ifosfamide", "NCSE" ] ]

Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.

[ [ "lithium", "Brugada type electrocardiographic changes" ], [ "propafenone", "Brugada type electrocardiographic changes" ] ]

Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia.

[ [ "imatinib mesylate", "Kaposi's sarcoma" ] ]

Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.

[ [ "Zidovudine", "birth defects" ] ]

Late lethal hepatitis B virus reactivation after rituximab treatment of low-grade cutaneous B-cell lymphoma.

[ [ "rituximab", "hepatitis B virus reactivation" ] ]

Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.

[ [ "clomipramine", "extrapyramidal symptoms" ], [ "clomipramine", "Seizures" ], [ "interferon beta-1a", "extrapyramidal symptoms" ], [ "interferon beta-1a", "Seizures" ] ]

Three patients developed proteinuria following gold therapy for rheumatoid arthritis.

[ [ "gold", "proteinuria" ] ]

We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.

[ [ "Warfarin", "stuttering" ], [ "Warfarin", "priapism" ] ]

In addition to the recognized arrhythmic complications, the authors emphasize myocardial necrosis as a possible further manifestation of amsacrine-related cardiotoxicity.

[ [ "amsacrine", "cardiotoxicity" ], [ "amsacrine", "myocardial necrosis" ] ]

Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy.

[ [ "hydroxychloroquine", "nephrosis" ] ]

A short review on imatinib-related hepatotoxicity is also presented.

[ [ "imatinib", "hepatotoxicity" ] ]

The authors report a further case of methimazole-associated liver damage and present a brief review of eleven previous cases found in the literature.

[ [ "methimazole", "liver damage" ] ]

The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.

[ [ "gold", "skin disturbances" ] ]

Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.

[ [ "cyproterone acetate", "Avascular necrosis of the femoral head" ] ]

PURPOSE: To describe transient structured visual hallucinations in a patient with vascular age-related macular degeneration (AMD), following an intravitreal Avastin-injection.

[ [ "Avastin", "transient structured visual hallucinations" ] ]

The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.

[ [ "insulin", "angioedema" ], [ "insulin", "urticaria" ], [ "NPH", "angioedema" ], [ "NPH", "urticaria" ] ]

We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.

[ [ "busulfan", "severe interstitial lung fibrosis" ], [ "melphalan", "severe interstitial lung fibrosis" ] ]

However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued.

[ [ "prednisone", "Cushingoid features" ] ]

We present the case of a 58-year-old woman who ingested more than 35 g of caffeine in a suicide attempt.

[ [ "caffeine", "suicide attempt" ] ]

Renal tubular acidosis secondary to FK506 in living donor liver transplantation: a case report.

[ [ "FK506", "Renal tubular acidosis" ] ]

The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.

[ [ "methotrexate", "nodules" ] ]

The possibility of severe rhabdomyolysis should be considered in a patient with water intoxication due to massive ingestion of caffeine-containing beverages.

[ [ "caffeine", "rhabdomyolysis" ], [ "caffeine", "water intoxication" ] ]

Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.

[ [ "flutamide", "decrease in prostate-specific antigen" ], [ "Flutamide", "Flutamide withdrawal syndrome" ], [ "flutamide", "Flutamide withdrawal syndrome" ], [ "Flutamide", "decrease in prostate-specific antigen" ] ]

Although it is difficult to be certain of the direct link of amiodarone on the basis of a single case, it is reasonable to presume that this histopathology is associated with amiodarone-induced hypothyroidism and that involution changes represent the hypofunctional status of this drug-induced disorder.

[ [ "amiodarone", "hypothyroidism" ] ]

The literature search found 12 cases of radiation recall caused by gemcitabine.

[ [ "gemcitabine", "radiation recall" ] ]

Cholestyramine induced hyperchloremic metabolic acidosis.

[ [ "Cholestyramine", "hyperchloremic metabolic acidosis" ] ]

An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.

[ [ "sulfamethoxazole", "symptomatic hypoglycemia" ], [ "glipizide", "symptomatic hypoglycemia" ], [ "trimethoprim", "symptomatic hypoglycemia" ], [ "TMP", "symptomatic hypoglycemia" ], [ "SMX", "symptomatic hypoglycemia" ] ]

Cardiopulmonary arrest following intravenous phenytoin loading.

[ [ "phenytoin", "Cardiopulmonary arrest" ] ]

Atenolol-induced pseudolymphoma.

[ [ "Atenolol", "pseudolymphoma" ] ]

Myoclonus associated with continuous dobutamine infusion in a patient with end-stage renal disease.

[ [ "dobutamine", "Myoclonus" ] ]

A 2-year-old mentally retarded boy with frontal lobe epilepsy presented with an episode that resembled heat stroke during the administration of zonisamide.

[ [ "zonisamide", "heat stroke" ] ]

Mequitazine seemed to play a part similar to chlorpromazine, and absence of mequitazine-induced photosensitivity may be due to a relatively low dosage of the drug.

[ [ "mequitazine", "photosensitivity" ] ]

Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.

[ [ "lenalidomide", "aplastic anemia" ] ]

A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.

[ [ "phenytoin", "erythroderma" ], [ "phenytoin", "pinhead-sized facial pustules" ], [ "phenytoin", "abnormal liver function tests" ], [ "phenytoin", "phenytoin hypersensitivity syndrome" ], [ "phenytoin", "tibial and facial oedema" ], [ "phenytoin", "fever" ] ]

BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.

[ [ "clozapine", "granulocytopenia" ] ]

Exfoliative dermatitis secondary to tobramycin sulfate.

[ [ "tobramycin sulfate", "Exfoliative dermatitis" ] ]

We describe a case of fibrosing alveolitis, diagnosed by lung biopsy, in a patient receiving amiodarone which responded to corticosteroid therapy.

[ [ "amiodarone", "fibrosing alveolitis" ] ]

Chronic fentanyl application induces adrenocortical insufficiency.

[ [ "fentanyl", "adrenocortical insufficiency" ] ]

Papillary necrosis associated with the HIV protease inhibitor indinavir.

[ [ "indinavir", "Papillary necrosis" ] ]

Acute interstitial nephritis due to pantoprazole.

[ [ "pantoprazole", "Acute interstitial nephritis" ] ]

Amiodarone is well recognized as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction.

[ [ "Amiodarone", "thyroid dysfunction" ] ]

Progressive pulmonary fibrosis complicating cyclophosphamide therapy.

[ [ "cyclophosphamide", "Progressive pulmonary fibrosis" ] ]

Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.

[ [ "IFN-beta", "inflammatory arthritis" ] ]

The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).

[ [ "methotrexate", "elevated liver transaminases" ], [ "methotrexate", "mild pruritus" ], [ "methotrexate", "mild neutropenia" ], [ "methotrexate", "bone pain" ], [ "methotrexate", "abdominal pain" ], [ "methotrexate", "nausea" ] ]

A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.

[ [ "CBZ", "tics" ], [ "CBZ", "movement disorders" ], [ "carbamazepine", "tics" ], [ "carbamazepine", "movement disorders" ] ]

CONCLUSIONS: Colchicine-induced myopathy should be excluded in patients with FMF who present with generalized muscle weakness.

[ [ "Colchicine", "myopathy" ] ]

During the first days of arsenic trioxide treatment a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes.

[ [ "arsenic trioxide", "decrease in the D-dimers" ], [ "arsenic trioxide", "slight decrease in peripheral blood leukocytes" ] ]

We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.

[ [ "cibenzoline", "blurred vision" ], [ "cibenzoline", "cibenzoline intoxication" ], [ "cibenzoline", "cardiac failure" ], [ "cibenzoline", "QRS broadening" ] ]

Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.

[ [ "clofazimine", "onycholysis" ], [ "clofazimine", "discoloration of nail plate" ], [ "clofazimine", "subungual hyperkeratosis" ] ]

Decreased plasma cortisol level during alprazolam treatment of panic disorder: a case report.

[ [ "alprazolam", "Decreased plasma cortisol level" ] ]

PURPOSE: To present a case of respiratory depression following the administration of nebulised morphine.

[ [ "morphine", "respiratory depression" ] ]

The harlequin color change and association with prostaglandin E1.

[ [ "prostaglandin E1", "harlequin color change" ] ]

Interstitial granulomatous dermatitis associated with darifenacin.

[ [ "darifenacin", "Interstitial granulomatous dermatitis" ] ]

The authors intend to carry out a case-control study on patients treated with tamoxifen for breast carcinoma to reveal the possible presence of endometrial carcinoma.

[ [ "tamoxifen", "endometrial carcinoma" ] ]

The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.

[ [ "valproate", "amenorrhea" ], [ "valproate", "gained weight" ], [ "valproate", "polycystic changes" ] ]

A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.

[ [ "phenobarbital", "icterus" ], [ "phenobarbital", "protein-losing enteropathy" ], [ "phenobarbital", "hypersensitivity" ], [ "phenobarbital", "alopecia" ], [ "phenobarbital", "a pruritic desquamating erythrodermic rash" ], [ "phenobarbital", "fever" ], [ "phenobarbital", "nephritis" ], [ "phenobarbital", "myositis" ] ]

Leflunomide-associated weight loss in rheumatoid arthritis.

[ [ "Leflunomide", "weight loss" ] ]

Diazepam use by pregnant women can be associated with a later presentation of withdrawal symptoms in the neonate than that induced by the use of other drugs.

[ [ "Diazepam", "withdrawal symptoms" ] ]

CASES: "A" was an 8-year-old boy with attention deficit and chronic tic disorder who developed obsessive-compulsive symptoms within 2 weeks of starting risperidone.

[ [ "risperidone", "obsessive-compulsive symptoms" ] ]

A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.

[ [ "Tegretol", "systemic lupus erythematosus (SLE)-like symptoms" ], [ "Tegretol", "leukopenia" ], [ "carbamazepine", "systemic lupus erythematosus (SLE)-like symptoms" ], [ "CBZ", "fever" ], [ "carbamazepine", "leukopenia" ], [ "CBZ", "rash" ], [ "CBZ", "positive anti-nuclear antibody" ], [ "CBZ", "leukopenia" ], [ "CBZ", "systemic lupus erythematosus (SLE)-like symptoms" ], [ "Tegretol", "fever" ], [ "carbamazepine", "rash" ], [ "Tegretol", "rash" ], [ "carbamazepine", "fever" ], [ "carbamazepine", "positive anti-nuclear antibody" ], [ "Tegretol", "positive anti-nuclear antibody" ] ]

PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.

[ [ "interferon alpha", "bilateral optic neuritis" ] ]

We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril.

[ [ "captopril", "pemphigus" ] ]

This is a report of a case of anuric ARF after high-dose mannitol infusion for treatment of narrow-angle glaucoma that readily responded to acute hemodialysis.

[ [ "mannitol", "anuric ARF" ] ]