harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
The male patient was treated with 225-mg/day clozapine and the time to the diagnosis of agranulocytosis was 6 weeks.	[ [ "clozapine", "agranulocytosis" ] ]
The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.	[ [ "hydroxyurea", "interstitial pneumonitis" ] ]
Severe hepatocellular dysfunction following cyproterone acetate therapy.	[ [ "cyproterone acetate", "Severe hepatocellular dysfunction" ] ]
BACKGROUND: Hypersensitivity reactions to cyclosporine are rare.	[ [ "cyclosporine", "Hypersensitivity reactions" ] ]
Statin-associated myasthenia gravis: report of 4 cases and review of the literature.	[ [ "Statin", "myasthenia gravis" ] ]
Cefuroxime-induced acute renal failure.	[ [ "Cefuroxime", "acute renal failure" ] ]
A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.	[ [ "bromocriptine", "pleuropulmonary abnormalities" ], [ "cabergoline", "pleuropulmonary abnormalities" ] ]
On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.	[ [ "magnesium sulfate", "edema" ], [ "terbutaline", "edema" ], [ "nifedipine", "edema" ], [ "betamethasone", "edema" ] ]
To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-beta therapy for the malignant melanoma.	[ [ "IFN-beta", "histological abnormalities of the glomerulus" ] ]
CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.	[ [ "clozapine", "granulocytopenia" ] ]
Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.	[ [ "fluvoxamine", "akathisia" ] ]
Allergic contact angioedema to benzoyl peroxide.	[ [ "benzoyl peroxide", "Allergic contact angioedema" ] ]
To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.	[ [ "amiodarone", "pulmonary toxicity" ] ]
Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.	[ [ "Interferon-alpha", "MPGN" ], [ "IFN-alpha", "MPGN" ] ]
Ulcerating enteritis associated with flucytosine therapy.	[ [ "flucytosine", "Ulcerating enteritis" ] ]
We describe a patient who developed granulocytopenia and fever after taking dipyrone and discuss the available literature.	[ [ "dipyrone", "granulocytopenia" ] ]
We report a 13 year-old male who developed life-threatening anaphylaxis early in the course of Increlex therapy.	[ [ "Increlex", "anaphylaxis" ] ]
Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.	[ [ "temozolomide", "Pneumocystis pneumonia" ], [ "temozolomide", "Listeria brain abscess" ], [ "temozolomide", "Kaposi's sarcoma" ] ]
Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.	[ [ "piperacillin", "tardive seizures" ], [ "cefotiam", "tardive seizures" ] ]
The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.	[ [ "ethambutol", "optic neuropathy" ] ]
Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.	[ [ "methotrexate", "Lymphoma" ] ]
Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration.	[ [ "celiprolol", "pneumonitis" ] ]
Development of persistent late onset asthma following treatment with captopril.	[ [ "captopril", "persistent late onset asthma" ] ]
Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.	[ [ "ouabain", "Minor electrocardiographical changes" ] ]
Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.	[ [ "ribavirin", "Cutaneous sarcoidosis" ], [ "interferon alfa", "Cutaneous sarcoidosis" ] ]
This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.	[ [ "aspirin", "tracheal compression" ] ]
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.	[ [ "pegvisomant", "hepatitis" ], [ "octreotide", "hepatitis" ] ]
She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany.	[ [ "tobramycin", "tetany" ] ]
Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.	[ [ "L-asparaginase", "Cerebrovascular complications" ], [ "L-asparaginase", "neuropsychological deficits" ], [ "L-asparaginase", "aphasia" ] ]
ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.	[ [ "ARA-C", "dermatologic toxicity" ], [ "ARA-C", "toxic epidermal necrolysis" ] ]
MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate.	[ [ "PCCs", "MI" ] ]
Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.	[ [ "topiramate", "angle closure glaucoma" ], [ "topiramate", "acute-onset myopia" ] ]
Edema associated with ibuprofen therapy.	[ [ "ibuprofen", "Edema" ] ]
Rapidly developing hyperglycemia during treatment with olanzapine.	[ [ "olanzapine", "hyperglycemia" ] ]
Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.	[ [ "Tacrolimus", "acute renal failure" ], [ "Tacrolimus", "HUS" ] ]
Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.	[ [ "all-trans retinoic acid", "Relapse in the external auditory canal of acute promyelocytic leukemia" ] ]
Protamine-induced fatal anaphylaxis.	[ [ "Protamine", "fatal anaphylaxis" ] ]
Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.	[ [ "heparin", "hyperkalemia" ] ]
The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufacturer.	[ [ "zafirlukast", "increase in the theophylline level" ], [ "theophylline", "increase in the theophylline level" ] ]
To the best of our knowledge, corneoscleral melting in the first postoperative week after a single intraoperative application of mitomycin C has not been reported.	[ [ "mitomycin C", "corneoscleral melting" ] ]
Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.	[ [ "cyclophosphamide", "Hepatic angiosarcoma" ] ]
DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.	[ [ "cisplatin", "Anaphylactoid reactions" ] ]
DISCUSSION: The Naranjo probability scale indicated a probable relationship between sertraline treatment and the onset of rhabdomyolysis.	[ [ "sertraline", "rhabdomyolysis" ] ]
Reduction of methylprednisolone dosage rather than insulin therapy resulted in better control of glycemia.	[ [ "methylprednisolone", "glycemia" ] ]
Fatal hepatitis after long-term pulse itraconazole treatment for onychomycosis.	[ [ "itraconazole", "Fatal hepatitis" ] ]
The elicitation of a movement disorder by trazodone: case report.	[ [ "trazodone", "movement disorder" ] ]
CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision.	[ [ "amiodarone HCl", "visual \"shining" ], [ "amiodarone HCl", "decreased vision" ], [ "amiodarone HCl", "glare" ], [ "amiodarone HCl", "color vision anomalies" ] ]
CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.	[ [ "IFN-alpha", "Hashimoto's disease" ] ]
Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.	[ [ "Clozapine", "tardive dyskinesia" ] ]
Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.	[ [ "lenalidomide", "Hypersensitivity pneumonitis-like syndrome" ] ]
Retinoic acid may increase the risk of bone marrow transplant nephropathy.	[ [ "Retinoic acid", "bone marrow transplant nephropathy" ] ]
CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.	[ [ "lovastatin", "rhabdomyolysis" ], [ "clarithromycin", "rhabdomyolysis" ], [ "azithromycin", "rhabdomyolysis" ] ]
We report a case of papillary necrosis in a patient treated with indinavir.	[ [ "indinavir", "papillary necrosis" ] ]
CONTEXT: Previous investigators have reported discrepancies between hematologic, marrow morphologic, and cytogenetic responses to imatinib mesylate among patients with chronic myeloid leukemia (CML).	[ [ "imatinib mesylate", "discrepancies between hematologic, marrow morphologic, and cytogenetic responses" ] ]
Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.	[ [ "PPA", "stroke" ], [ "Phenylpropanolamine", "stroke" ], [ "Phenylpropanolamine", "neurologic events" ], [ "PPA", "neurologic events" ] ]
The nephrotic syndrome developed in a patient receiving therapy with gold for rheumatoid arthritis.	[ [ "gold", "nephrotic syndrome" ] ]
Although there have been numerous reports of effusions, none have provided complete pleural fluid analysis; therefore, we report 2 patients with dasatinib-induced pleural effusion with complete pleural fluid analysis.	[ [ "dasatinib", "pleural effusion" ] ]
Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?	[ [ "etoposide", "Secondary leukemia" ] ]
Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.	[ [ "radioiodine", "hypothyroidism" ] ]
Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.	[ [ "azathioprine", "myelosuppression" ] ]
We reported a case of disulfiram-induced hepatitis with unique clinical features and compared our case with others in the literature.	[ [ "disulfiram", "hepatitis" ] ]
In addition, an immediate erythematous macule was observed on the photopatch test site of mequitazine directly after UV exposure which was similar to the immediate erythema noted in chlorpromazine photoallergy.	[ [ "mequitazine", "immediate erythema" ], [ "mequitazine", "erythematous macule" ] ]
We report on a patient with acromegaly who developed severe drug-induced hepatitis during combined treatment with the long-acting somatostatin-analog octreotide and the GH receptor antagonist pegvisomant.	[ [ "pegvisomant", "hepatitis" ], [ "octreotide", "hepatitis" ] ]
Though they are generally considered safe, there have been a few reports of myocardial infarction and stroke associated with triptan use.	[ [ "triptan", "myocardial infarction" ], [ "triptan", "stroke" ] ]
We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.	[ [ "cytosine arabinoside", "severe demyelinating peripheral neuropathy" ], [ "cytosine arabinoside", "death" ], [ "cytosine arabinoside", "Horner's syndrome" ] ]
Flaccid quadriparesis was noted after discontinuation of vecuronium.	[ [ "vecuronium", "Flaccid quadriparesis" ] ]
A 53-year-old male, without any prior history of psychosis, developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma.	[ [ "bromocriptine", "schizophrenia" ] ]
We report a myeloma patient who developed severe paralytic ileus during bortezomib therapy, which presented in the context of progressive constipation without other known causes and which regressed promptly with medical management after drug cessation, suggesting a direct causal relationship.	[ [ "bortezomib", "severe paralytic ileus" ] ]
OBJECTIVE: To report a case of possible foscarnet-induced severe hypomagnesemia and other electrolyte disorders.	[ [ "foscarnet", "electrolyte disorders" ], [ "foscarnet", "severe hypomagnesemia" ] ]
BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.	[ [ "sodium valproate", "Reproductive endocrine disorders" ], [ "sodium valproate", "polycystic ovaries" ], [ "sodium valproate", "hyperandrogenism" ], [ "sodium valproate", "menstrual disorders" ] ]
Trazodone-induced transient hypomanic symptoms and their management.	[ [ "Trazodone", "transient hypomanic symptoms" ] ]
Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block.	[ [ "amiodarone", "Atrioventricular block" ], [ "amiodarone", "hypothyroidism" ] ]
Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.	[ [ "ethambutol", "optic neuropathy" ] ]
Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.	[ [ "minocycline", "lymphadenopathy" ], [ "minocycline", "eosinophilia" ], [ "minocycline", "dermatitis" ], [ "minocycline", "lymphocytosis" ], [ "minocycline", "Fever" ], [ "minocycline", "hepatitis" ] ]
We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.	[ [ "yohimbine", "worsening of Raynaud's phenomenon" ] ]
Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.	[ [ "Calcipotriol", "allergic reactions" ], [ "Calcipotriol", "irritation of the skin" ] ]
The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor.	[ [ "ofloxacin", "renal insufficiency" ], [ "ofloxacin", "seizures" ] ]
Syndrome of inappropriate antidiuretic hormone associated with vinorelbine therapy.	[ [ "vinorelbine", "Syndrome of inappropriate antidiuretic hormone" ] ]
Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.	[ [ "prednisone", "Hypertension" ], [ "cyclosporine", "Hypertension" ] ]
The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.	[ [ "gold", "respiratory failure" ], [ "gold", "pulmonary toxicity" ] ]
Symptoms and signs of augmentation were related to low plasma levodopa levels, abating 75 minutes after oral levodopa administration and reappearing after 3 hours, closely mirroring the rapid rise and fall of plasma levodopa concentration.	[ [ "levodopa", "augmentation" ] ]
When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.	[ [ "lithium", "intense anxiety" ], [ "lithium", "neurotoxicity" ], [ "lithium", "psychotic symptoms" ] ]
We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.	[ [ "efavirenz", "psychosis" ] ]
We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).	[ [ "ethanol injection", "cutaneous seeding" ] ]
Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature.	[ [ "acetazolamide", "aplastic anemia" ], [ "methazolamide", "aplastic anemia" ] ]
A 68-year-old female patient with advanced ovarian carcinoma collapsed whilst receiving a carboplatin and cyclophosphamide infusion.	[ [ "cyclophosphamide", "collapsed" ], [ "carboplatin", "collapsed" ] ]
OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.	[ [ "propylthiouracil", "antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis" ], [ "PTU", "ototoxicity" ], [ "propylthiouracil", "ototoxicity" ], [ "PTU", "antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis" ] ]
Although the existence of an acute pericarditis or an acute myocarditis as possible causes of the ST elevation cannot be fully ruled out, the sudden onset, prominent magnitude, and brief duration of the ST elevation are perhaps more indicative of an acute ischemic event, possibly related to a transient coronary vasoconstriction induced by the dopamine infusion.	[ [ "dopamine", "coronary vasoconstriction" ] ]
Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.	[ [ "Acyclovir", "neurologic symptoms" ] ]
Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.	[ [ "carboplatin", "Fatal lung fibrosis" ], [ "paclitaxel", "Fatal lung fibrosis" ] ]
We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.	[ [ "dexmedetomidine", "bradycardia" ], [ "glycopyrrolate", "exaggerated increase of arterial blood pressure" ] ]
An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.	[ [ "clofazimine", "severe enteropathy" ] ]
We report on a 56-year-old female who exhibited drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion on electrocardiogram was demonstrated reproducibly shortly after the administration of oral pirmenol therapy.	[ [ "pirmenol", "T wave inversion" ], [ "pirmenol", "prolongation of the QT interval" ] ]
Subsequent in vivo/vitro studies clearly demonstrated that the neurological effects were due to a synergistic action of desferrioxamine and prochlorperazine, probably resulting in exceptional fluxes of intra/extra cellular iron/copper disturbing noradrenergic and serotonergic systems.	[ [ "desferrioxamine", "neurological effects" ], [ "prochlorperazine", "neurological effects" ] ]
Ethambutol toxicity manifesting as acute onset psychosis.	[ [ "Ethambutol", "acute onset psychosis" ] ]
Erythema multiforme bullosum due to rifampicin.	[ [ "rifampicin", "Erythema multiforme bullosum" ] ]
Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.	[ [ "adrenaline", "Dilated cardiomyopathy" ] ]
We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.	[ [ "doxycycline", "hypoglycemia" ] ]
A case of SIADH associated with desipramine treatment in an elderly depressed woman is described.	[ [ "desipramine", "SIADH" ] ]
We presented the case of a patient who developed a cutaneous reaction induced by captopril with positive patch test.	[ [ "captopril", "cutaneous reaction" ] ]

The male patient was treated with 225-mg/day clozapine and the time to the diagnosis of agranulocytosis was 6 weeks.

[ [ "clozapine", "agranulocytosis" ] ]

The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.

[ [ "hydroxyurea", "interstitial pneumonitis" ] ]

Severe hepatocellular dysfunction following cyproterone acetate therapy.

[ [ "cyproterone acetate", "Severe hepatocellular dysfunction" ] ]

BACKGROUND: Hypersensitivity reactions to cyclosporine are rare.

[ [ "cyclosporine", "Hypersensitivity reactions" ] ]

Statin-associated myasthenia gravis: report of 4 cases and review of the literature.

[ [ "Statin", "myasthenia gravis" ] ]

Cefuroxime-induced acute renal failure.

[ [ "Cefuroxime", "acute renal failure" ] ]

A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.

[ [ "bromocriptine", "pleuropulmonary abnormalities" ], [ "cabergoline", "pleuropulmonary abnormalities" ] ]

On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.

[ [ "magnesium sulfate", "edema" ], [ "terbutaline", "edema" ], [ "nifedipine", "edema" ], [ "betamethasone", "edema" ] ]

To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-beta therapy for the malignant melanoma.

[ [ "IFN-beta", "histological abnormalities of the glomerulus" ] ]

CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.

[ [ "clozapine", "granulocytopenia" ] ]

Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.

[ [ "fluvoxamine", "akathisia" ] ]

Allergic contact angioedema to benzoyl peroxide.

[ [ "benzoyl peroxide", "Allergic contact angioedema" ] ]

To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.

[ [ "amiodarone", "pulmonary toxicity" ] ]

Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.

[ [ "Interferon-alpha", "MPGN" ], [ "IFN-alpha", "MPGN" ] ]

Ulcerating enteritis associated with flucytosine therapy.

[ [ "flucytosine", "Ulcerating enteritis" ] ]

We describe a patient who developed granulocytopenia and fever after taking dipyrone and discuss the available literature.

[ [ "dipyrone", "granulocytopenia" ] ]

We report a 13 year-old male who developed life-threatening anaphylaxis early in the course of Increlex therapy.

[ [ "Increlex", "anaphylaxis" ] ]

Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.

[ [ "temozolomide", "Pneumocystis pneumonia" ], [ "temozolomide", "Listeria brain abscess" ], [ "temozolomide", "Kaposi's sarcoma" ] ]

Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.

[ [ "piperacillin", "tardive seizures" ], [ "cefotiam", "tardive seizures" ] ]

The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.

[ [ "ethambutol", "optic neuropathy" ] ]

Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.

[ [ "methotrexate", "Lymphoma" ] ]

Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration.

[ [ "celiprolol", "pneumonitis" ] ]

Development of persistent late onset asthma following treatment with captopril.

[ [ "captopril", "persistent late onset asthma" ] ]

Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.

[ [ "ouabain", "Minor electrocardiographical changes" ] ]

Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.

[ [ "ribavirin", "Cutaneous sarcoidosis" ], [ "interferon alfa", "Cutaneous sarcoidosis" ] ]

This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.

[ [ "aspirin", "tracheal compression" ] ]

Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.

[ [ "pegvisomant", "hepatitis" ], [ "octreotide", "hepatitis" ] ]

She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany.

[ [ "tobramycin", "tetany" ] ]

Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.

[ [ "L-asparaginase", "Cerebrovascular complications" ], [ "L-asparaginase", "neuropsychological deficits" ], [ "L-asparaginase", "aphasia" ] ]

ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.

[ [ "ARA-C", "dermatologic toxicity" ], [ "ARA-C", "toxic epidermal necrolysis" ] ]

MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate.

[ [ "PCCs", "MI" ] ]

Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.

[ [ "topiramate", "angle closure glaucoma" ], [ "topiramate", "acute-onset myopia" ] ]

Edema associated with ibuprofen therapy.

[ [ "ibuprofen", "Edema" ] ]

Rapidly developing hyperglycemia during treatment with olanzapine.

[ [ "olanzapine", "hyperglycemia" ] ]

Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.

[ [ "Tacrolimus", "acute renal failure" ], [ "Tacrolimus", "HUS" ] ]

Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.

[ [ "all-trans retinoic acid", "Relapse in the external auditory canal of acute promyelocytic leukemia" ] ]

Protamine-induced fatal anaphylaxis.

[ [ "Protamine", "fatal anaphylaxis" ] ]

Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.

[ [ "heparin", "hyperkalemia" ] ]

The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufacturer.

[ [ "zafirlukast", "increase in the theophylline level" ], [ "theophylline", "increase in the theophylline level" ] ]

To the best of our knowledge, corneoscleral melting in the first postoperative week after a single intraoperative application of mitomycin C has not been reported.

[ [ "mitomycin C", "corneoscleral melting" ] ]

Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.

[ [ "cyclophosphamide", "Hepatic angiosarcoma" ] ]

DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.

[ [ "cisplatin", "Anaphylactoid reactions" ] ]

DISCUSSION: The Naranjo probability scale indicated a probable relationship between sertraline treatment and the onset of rhabdomyolysis.

[ [ "sertraline", "rhabdomyolysis" ] ]

Reduction of methylprednisolone dosage rather than insulin therapy resulted in better control of glycemia.

[ [ "methylprednisolone", "glycemia" ] ]

Fatal hepatitis after long-term pulse itraconazole treatment for onychomycosis.

[ [ "itraconazole", "Fatal hepatitis" ] ]

The elicitation of a movement disorder by trazodone: case report.

[ [ "trazodone", "movement disorder" ] ]

CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision.

[ [ "amiodarone HCl", "visual \"shining" ], [ "amiodarone HCl", "decreased vision" ], [ "amiodarone HCl", "glare" ], [ "amiodarone HCl", "color vision anomalies" ] ]

CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.

[ [ "IFN-alpha", "Hashimoto's disease" ] ]

Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.

[ [ "Clozapine", "tardive dyskinesia" ] ]

Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.

[ [ "lenalidomide", "Hypersensitivity pneumonitis-like syndrome" ] ]

Retinoic acid may increase the risk of bone marrow transplant nephropathy.

[ [ "Retinoic acid", "bone marrow transplant nephropathy" ] ]

CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.

[ [ "lovastatin", "rhabdomyolysis" ], [ "clarithromycin", "rhabdomyolysis" ], [ "azithromycin", "rhabdomyolysis" ] ]

We report a case of papillary necrosis in a patient treated with indinavir.

[ [ "indinavir", "papillary necrosis" ] ]

CONTEXT: Previous investigators have reported discrepancies between hematologic, marrow morphologic, and cytogenetic responses to imatinib mesylate among patients with chronic myeloid leukemia (CML).

[ [ "imatinib mesylate", "discrepancies between hematologic, marrow morphologic, and cytogenetic responses" ] ]

Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.

[ [ "PPA", "stroke" ], [ "Phenylpropanolamine", "stroke" ], [ "Phenylpropanolamine", "neurologic events" ], [ "PPA", "neurologic events" ] ]

The nephrotic syndrome developed in a patient receiving therapy with gold for rheumatoid arthritis.

[ [ "gold", "nephrotic syndrome" ] ]

Although there have been numerous reports of effusions, none have provided complete pleural fluid analysis; therefore, we report 2 patients with dasatinib-induced pleural effusion with complete pleural fluid analysis.

[ [ "dasatinib", "pleural effusion" ] ]

Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?

[ [ "etoposide", "Secondary leukemia" ] ]

Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.

[ [ "radioiodine", "hypothyroidism" ] ]

Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.

[ [ "azathioprine", "myelosuppression" ] ]

We reported a case of disulfiram-induced hepatitis with unique clinical features and compared our case with others in the literature.

[ [ "disulfiram", "hepatitis" ] ]

In addition, an immediate erythematous macule was observed on the photopatch test site of mequitazine directly after UV exposure which was similar to the immediate erythema noted in chlorpromazine photoallergy.

[ [ "mequitazine", "immediate erythema" ], [ "mequitazine", "erythematous macule" ] ]

We report on a patient with acromegaly who developed severe drug-induced hepatitis during combined treatment with the long-acting somatostatin-analog octreotide and the GH receptor antagonist pegvisomant.

[ [ "pegvisomant", "hepatitis" ], [ "octreotide", "hepatitis" ] ]

Though they are generally considered safe, there have been a few reports of myocardial infarction and stroke associated with triptan use.

[ [ "triptan", "myocardial infarction" ], [ "triptan", "stroke" ] ]

We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.

[ [ "cytosine arabinoside", "severe demyelinating peripheral neuropathy" ], [ "cytosine arabinoside", "death" ], [ "cytosine arabinoside", "Horner's syndrome" ] ]

Flaccid quadriparesis was noted after discontinuation of vecuronium.

[ [ "vecuronium", "Flaccid quadriparesis" ] ]

A 53-year-old male, without any prior history of psychosis, developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma.

[ [ "bromocriptine", "schizophrenia" ] ]

We report a myeloma patient who developed severe paralytic ileus during bortezomib therapy, which presented in the context of progressive constipation without other known causes and which regressed promptly with medical management after drug cessation, suggesting a direct causal relationship.

[ [ "bortezomib", "severe paralytic ileus" ] ]

OBJECTIVE: To report a case of possible foscarnet-induced severe hypomagnesemia and other electrolyte disorders.

[ [ "foscarnet", "electrolyte disorders" ], [ "foscarnet", "severe hypomagnesemia" ] ]

BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.

[ [ "sodium valproate", "Reproductive endocrine disorders" ], [ "sodium valproate", "polycystic ovaries" ], [ "sodium valproate", "hyperandrogenism" ], [ "sodium valproate", "menstrual disorders" ] ]

Trazodone-induced transient hypomanic symptoms and their management.

[ [ "Trazodone", "transient hypomanic symptoms" ] ]

Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block.

[ [ "amiodarone", "Atrioventricular block" ], [ "amiodarone", "hypothyroidism" ] ]

Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.

[ [ "ethambutol", "optic neuropathy" ] ]

Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.

[ [ "minocycline", "lymphadenopathy" ], [ "minocycline", "eosinophilia" ], [ "minocycline", "dermatitis" ], [ "minocycline", "lymphocytosis" ], [ "minocycline", "Fever" ], [ "minocycline", "hepatitis" ] ]

We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.

[ [ "yohimbine", "worsening of Raynaud's phenomenon" ] ]

Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.

[ [ "Calcipotriol", "allergic reactions" ], [ "Calcipotriol", "irritation of the skin" ] ]

The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor.

[ [ "ofloxacin", "renal insufficiency" ], [ "ofloxacin", "seizures" ] ]

Syndrome of inappropriate antidiuretic hormone associated with vinorelbine therapy.

[ [ "vinorelbine", "Syndrome of inappropriate antidiuretic hormone" ] ]

Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.

[ [ "prednisone", "Hypertension" ], [ "cyclosporine", "Hypertension" ] ]

The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.

[ [ "gold", "respiratory failure" ], [ "gold", "pulmonary toxicity" ] ]

Symptoms and signs of augmentation were related to low plasma levodopa levels, abating 75 minutes after oral levodopa administration and reappearing after 3 hours, closely mirroring the rapid rise and fall of plasma levodopa concentration.

[ [ "levodopa", "augmentation" ] ]

When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.

[ [ "lithium", "intense anxiety" ], [ "lithium", "neurotoxicity" ], [ "lithium", "psychotic symptoms" ] ]

We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.

[ [ "efavirenz", "psychosis" ] ]

We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).

[ [ "ethanol injection", "cutaneous seeding" ] ]

Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature.

[ [ "acetazolamide", "aplastic anemia" ], [ "methazolamide", "aplastic anemia" ] ]

A 68-year-old female patient with advanced ovarian carcinoma collapsed whilst receiving a carboplatin and cyclophosphamide infusion.

[ [ "cyclophosphamide", "collapsed" ], [ "carboplatin", "collapsed" ] ]

OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

[ [ "propylthiouracil", "antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis" ], [ "PTU", "ototoxicity" ], [ "propylthiouracil", "ototoxicity" ], [ "PTU", "antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis" ] ]

Although the existence of an acute pericarditis or an acute myocarditis as possible causes of the ST elevation cannot be fully ruled out, the sudden onset, prominent magnitude, and brief duration of the ST elevation are perhaps more indicative of an acute ischemic event, possibly related to a transient coronary vasoconstriction induced by the dopamine infusion.

[ [ "dopamine", "coronary vasoconstriction" ] ]

Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.

[ [ "Acyclovir", "neurologic symptoms" ] ]

Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.

[ [ "carboplatin", "Fatal lung fibrosis" ], [ "paclitaxel", "Fatal lung fibrosis" ] ]

We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.

[ [ "dexmedetomidine", "bradycardia" ], [ "glycopyrrolate", "exaggerated increase of arterial blood pressure" ] ]

An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.

[ [ "clofazimine", "severe enteropathy" ] ]

We report on a 56-year-old female who exhibited drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion on electrocardiogram was demonstrated reproducibly shortly after the administration of oral pirmenol therapy.

[ [ "pirmenol", "T wave inversion" ], [ "pirmenol", "prolongation of the QT interval" ] ]

Subsequent in vivo/vitro studies clearly demonstrated that the neurological effects were due to a synergistic action of desferrioxamine and prochlorperazine, probably resulting in exceptional fluxes of intra/extra cellular iron/copper disturbing noradrenergic and serotonergic systems.

[ [ "desferrioxamine", "neurological effects" ], [ "prochlorperazine", "neurological effects" ] ]

Ethambutol toxicity manifesting as acute onset psychosis.

[ [ "Ethambutol", "acute onset psychosis" ] ]

Erythema multiforme bullosum due to rifampicin.

[ [ "rifampicin", "Erythema multiforme bullosum" ] ]

Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.

[ [ "adrenaline", "Dilated cardiomyopathy" ] ]

We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.

[ [ "doxycycline", "hypoglycemia" ] ]

A case of SIADH associated with desipramine treatment in an elderly depressed woman is described.

[ [ "desipramine", "SIADH" ] ]

We presented the case of a patient who developed a cutaneous reaction induced by captopril with positive patch test.

[ [ "captopril", "cutaneous reaction" ] ]