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Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.
|
[
{
"ade": "Skin necrosis",
"drug": "heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.",
"role": "user"
},
{
"content": "[{'ade': 'Skin necrosis', 'drug': 'heparin'}]",
"role": "assistant"
}
] |
A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).
|
[
{
"ade": "AVT",
"drug": "quinidine"
},
{
"ade": "AVT",
"drug": "disopyramide"
},
{
"ade": "torsade de pointes",
"drug": "quinidine"
},
{
"ade": "atypical ventricular tachycardia",
"drug": "quinidine"
},
{
"ade": "AVT",
"drug": "amiodarone"
},
{
"ade": "torsade de pointes",
"drug": "amiodarone"
},
{
"ade": "atypical ventricular tachycardia",
"drug": "disopyramide"
},
{
"ade": "atypical ventricular tachycardia",
"drug": "amiodarone"
},
{
"ade": "torsade de pointes",
"drug": "disopyramide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",
"role": "user"
},
{
"content": "[{'ade': 'AVT', 'drug': 'quinidine'}, {'ade': 'AVT', 'drug': 'disopyramide'}, {'ade': 'torsade de pointes', 'drug': 'quinidine'}, {'ade': 'atypical ventricular tachycardia', 'drug': 'quinidine'}, {'ade': 'AVT', 'drug': 'amiodarone'}, {'ade': 'torsade de pointes', 'drug': 'amiodarone'}, {'ade': 'atypical ventricular tachycardia', 'drug': 'disopyramide'}, {'ade': 'atypical ventricular tachycardia', 'drug': 'amiodarone'}, {'ade': 'torsade de pointes', 'drug': 'disopyramide'}]",
"role": "assistant"
}
] |
A patient with severe cholestatic jaundice induced by captopril is presented.
|
[
{
"ade": "severe cholestatic jaundice",
"drug": "captopril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient with severe cholestatic jaundice induced by captopril is presented.",
"role": "user"
},
{
"content": "[{'ade': 'severe cholestatic jaundice', 'drug': 'captopril'}]",
"role": "assistant"
}
] |
Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.
|
[
{
"ade": "flare-up",
"drug": "goserelin acetate"
},
{
"ade": "worsening pleuritis carcinomatosa",
"drug": "goserelin acetate"
},
{
"ade": "severe dyspnea",
"drug": "goserelin acetate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.",
"role": "user"
},
{
"content": "[{'ade': 'flare-up', 'drug': 'goserelin acetate'}, {'ade': 'worsening pleuritis carcinomatosa', 'drug': 'goserelin acetate'}, {'ade': 'severe dyspnea', 'drug': 'goserelin acetate'}]",
"role": "assistant"
}
] |
After stopping indapamide, glucose tolerance impairing may be reversed.
|
[
{
"ade": "glucose tolerance impairing",
"drug": "indapamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After stopping indapamide, glucose tolerance impairing may be reversed.",
"role": "user"
},
{
"content": "[{'ade': 'glucose tolerance impairing', 'drug': 'indapamide'}]",
"role": "assistant"
}
] |
Intrathecal methotrexate-induced acute cerebellar syndrome.
|
[
{
"ade": "acute cerebellar syndrome",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Intrathecal methotrexate-induced acute cerebellar syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'acute cerebellar syndrome', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.
|
[
{
"ade": "parkinsonism",
"drug": "metoclopramide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.",
"role": "user"
},
{
"content": "[{'ade': 'parkinsonism', 'drug': 'metoclopramide'}]",
"role": "assistant"
}
] |
Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.
|
[
{
"ade": "myocardial ischemia",
"drug": "BCNU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.",
"role": "user"
},
{
"content": "[{'ade': 'myocardial ischemia', 'drug': 'BCNU'}]",
"role": "assistant"
}
] |
Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.
|
[
{
"ade": "thrombocytopenia",
"drug": "IFN"
},
{
"ade": "hypoalbuminemia",
"drug": "IFN"
},
{
"ade": "ocular side effects",
"drug": "IFN"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'IFN'}, {'ade': 'hypoalbuminemia', 'drug': 'IFN'}, {'ade': 'ocular side effects', 'drug': 'IFN'}]",
"role": "assistant"
}
] |
Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.
|
[
{
"ade": "multiple skin cancers",
"drug": "hydroxyurea"
},
{
"ade": "longitudinal melanonychia",
"drug": "hydroxyurea"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.",
"role": "user"
},
{
"content": "[{'ade': 'multiple skin cancers', 'drug': 'hydroxyurea'}, {'ade': 'longitudinal melanonychia', 'drug': 'hydroxyurea'}]",
"role": "assistant"
}
] |
Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.
|
[
{
"ade": "cortical negative myoclonus",
"drug": "pregabalin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.",
"role": "user"
},
{
"content": "[{'ade': 'cortical negative myoclonus', 'drug': 'pregabalin'}]",
"role": "assistant"
}
] |
The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.
|
[
{
"ade": "grand mal seizure",
"drug": "propranolol"
},
{
"ade": "photosensitivity",
"drug": "propranolol"
},
{
"ade": "delirium",
"drug": "propranolol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.",
"role": "user"
},
{
"content": "[{'ade': 'grand mal seizure', 'drug': 'propranolol'}, {'ade': 'photosensitivity', 'drug': 'propranolol'}, {'ade': 'delirium', 'drug': 'propranolol'}]",
"role": "assistant"
}
] |
Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.
|
[
{
"ade": "anaphylaxis",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.",
"role": "user"
},
{
"content": "[{'ade': 'anaphylaxis', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Amphotericin B nephrotoxicity in humans decreased by salt repletion.
|
[
{
"ade": "nephrotoxicity",
"drug": "Amphotericin B"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Amphotericin B nephrotoxicity in humans decreased by salt repletion.",
"role": "user"
},
{
"content": "[{'ade': 'nephrotoxicity', 'drug': 'Amphotericin B'}]",
"role": "assistant"
}
] |
Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.
|
[
{
"ade": "hepatotoxicity",
"drug": "amiodarone"
},
{
"ade": "aggravation of arrhythmia",
"drug": "amiodarone"
},
{
"ade": "pulmonary toxicity",
"drug": "amiodarone"
},
{
"ade": "thyroid diseases",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.",
"role": "user"
},
{
"content": "[{'ade': 'hepatotoxicity', 'drug': 'amiodarone'}, {'ade': 'aggravation of arrhythmia', 'drug': 'amiodarone'}, {'ade': 'pulmonary toxicity', 'drug': 'amiodarone'}, {'ade': 'thyroid diseases', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.
|
[
{
"ade": "angio-oedema",
"drug": "irbesartan"
},
{
"ade": "hypotensive shock",
"drug": "irbesartan"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.",
"role": "user"
},
{
"content": "[{'ade': 'angio-oedema', 'drug': 'irbesartan'}, {'ade': 'hypotensive shock', 'drug': 'irbesartan'}]",
"role": "assistant"
}
] |
In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.
|
[
{
"ade": "cutaneous herpes zoster",
"drug": "cytarabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.",
"role": "user"
},
{
"content": "[{'ade': 'cutaneous herpes zoster', 'drug': 'cytarabine'}]",
"role": "assistant"
}
] |
We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.
|
[
{
"ade": "choroidal detachment",
"drug": "dorzolamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.",
"role": "user"
},
{
"content": "[{'ade': 'choroidal detachment', 'drug': 'dorzolamide'}]",
"role": "assistant"
}
] |
After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.
|
[
{
"ade": "blindness",
"drug": "lithium"
},
{
"ade": "CPM",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.",
"role": "user"
},
{
"content": "[{'ade': 'blindness', 'drug': 'lithium'}, {'ade': 'CPM', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS).
|
[
{
"ade": "thrombosis syndrome",
"drug": "heparin"
},
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS).",
"role": "user"
},
{
"content": "[{'ade': 'thrombosis syndrome', 'drug': 'heparin'}, {'ade': 'thrombocytopenia', 'drug': 'heparin'}]",
"role": "assistant"
}
] |
Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.
|
[
{
"ade": "Delayed pseudocyst of the pancreas",
"drug": "L-asparaginase"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.",
"role": "user"
},
{
"content": "[{'ade': 'Delayed pseudocyst of the pancreas', 'drug': 'L-asparaginase'}]",
"role": "assistant"
}
] |
Captopril-induced acute reversible renal failure.
|
[
{
"ade": "acute reversible renal failure",
"drug": "Captopril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Captopril-induced acute reversible renal failure.",
"role": "user"
},
{
"content": "[{'ade': 'acute reversible renal failure', 'drug': 'Captopril'}]",
"role": "assistant"
}
] |
Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.
|
[
{
"ade": "neurologic toxic effects",
"drug": "Sulindac"
},
{
"ade": "neurologic toxic effects",
"drug": "Clinoril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.",
"role": "user"
},
{
"content": "[{'ade': 'neurologic toxic effects', 'drug': 'Sulindac'}, {'ade': 'neurologic toxic effects', 'drug': 'Clinoril'}]",
"role": "assistant"
}
] |
Acute leukopenia associated with silver sulfadiazine therapy.
|
[
{
"ade": "Acute leukopenia",
"drug": "silver sulfadiazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute leukopenia associated with silver sulfadiazine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Acute leukopenia', 'drug': 'silver sulfadiazine'}]",
"role": "assistant"
}
] |
Intranasal desmopressin-induced hyponatremia.
|
[
{
"ade": "hyponatremia",
"drug": "desmopressin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Intranasal desmopressin-induced hyponatremia.",
"role": "user"
},
{
"content": "[{'ade': 'hyponatremia', 'drug': 'desmopressin'}]",
"role": "assistant"
}
] |
While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.
|
[
{
"ade": "renal failure",
"drug": "dextran"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.",
"role": "user"
},
{
"content": "[{'ade': 'renal failure', 'drug': 'dextran'}]",
"role": "assistant"
}
] |
Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.
|
[
{
"ade": "cicatricial entropion",
"drug": "dipivefrin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.",
"role": "user"
},
{
"content": "[{'ade': 'cicatricial entropion', 'drug': 'dipivefrin'}]",
"role": "assistant"
}
] |
Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.
|
[
{
"ade": "Methemoglobinemia",
"drug": "dapsone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.",
"role": "user"
},
{
"content": "[{'ade': 'Methemoglobinemia', 'drug': 'dapsone'}]",
"role": "assistant"
}
] |
Isoniazid and ethambutol as a cause of optic neuropathy.
|
[
{
"ade": "optic neuropathy",
"drug": "Isoniazid"
},
{
"ade": "optic neuropathy",
"drug": "ethambutol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Isoniazid and ethambutol as a cause of optic neuropathy.",
"role": "user"
},
{
"content": "[{'ade': 'optic neuropathy', 'drug': 'Isoniazid'}, {'ade': 'optic neuropathy', 'drug': 'ethambutol'}]",
"role": "assistant"
}
] |
We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.
|
[
{
"ade": "ARDS",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "ARDS",
"drug": "pegIFNalpha-2a"
},
{
"ade": "ARDS",
"drug": "ribavirin"
},
{
"ade": "adult respiratory distress syndrome",
"drug": "ribavirin"
},
{
"ade": "adult respiratory distress syndrome",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "adult respiratory distress syndrome",
"drug": "pegIFNalpha-2a"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.",
"role": "user"
},
{
"content": "[{'ade': 'ARDS', 'drug': 'pegylated interferon alpha-2a'}, {'ade': 'ARDS', 'drug': 'pegIFNalpha-2a'}, {'ade': 'ARDS', 'drug': 'ribavirin'}, {'ade': 'adult respiratory distress syndrome', 'drug': 'ribavirin'}, {'ade': 'adult respiratory distress syndrome', 'drug': 'pegylated interferon alpha-2a'}, {'ade': 'adult respiratory distress syndrome', 'drug': 'pegIFNalpha-2a'}]",
"role": "assistant"
}
] |
OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.
|
[
{
"ade": "lipoatrophies",
"drug": "insulin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.",
"role": "user"
},
{
"content": "[{'ade': 'lipoatrophies', 'drug': 'insulin'}]",
"role": "assistant"
}
] |
Nephropathy caused by methicillin therapy for staphylococcal septicemia.
|
[
{
"ade": "Nephropathy",
"drug": "methicillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nephropathy caused by methicillin therapy for staphylococcal septicemia.",
"role": "user"
},
{
"content": "[{'ade': 'Nephropathy', 'drug': 'methicillin'}]",
"role": "assistant"
}
] |
PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.
|
[
{
"ade": "glaucoma",
"drug": "triamcinolone acetate"
},
{
"ade": "glaucoma",
"drug": "corticosteroid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.",
"role": "user"
},
{
"content": "[{'ade': 'glaucoma', 'drug': 'triamcinolone acetate'}, {'ade': 'glaucoma', 'drug': 'corticosteroid'}]",
"role": "assistant"
}
] |
Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.
|
[
{
"ade": "hypersensitivity syndrome",
"drug": "carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity syndrome', 'drug': 'carbamazepine'}]",
"role": "assistant"
}
] |
In these patients, long-acting octreotide may trigger serious hypoglycemia.
|
[
{
"ade": "serious hypoglycemia",
"drug": "octreotide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In these patients, long-acting octreotide may trigger serious hypoglycemia.",
"role": "user"
},
{
"content": "[{'ade': 'serious hypoglycemia', 'drug': 'octreotide'}]",
"role": "assistant"
}
] |
This is the first report of UFT-induced scleroderma-like reaction.
|
[
{
"ade": "UFT-induced scleroderma-like reaction",
"drug": "UFT"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the first report of UFT-induced scleroderma-like reaction.",
"role": "user"
},
{
"content": "[{'ade': 'UFT-induced scleroderma-like reaction', 'drug': 'UFT'}]",
"role": "assistant"
}
] |
We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.
|
[
{
"ade": "penile fibrosis",
"drug": "papaverine"
},
{
"ade": "penile fibrosis",
"drug": "phentolamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.",
"role": "user"
},
{
"content": "[{'ade': 'penile fibrosis', 'drug': 'papaverine'}, {'ade': 'penile fibrosis', 'drug': 'phentolamine'}]",
"role": "assistant"
}
] |
CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.
|
[
{
"ade": "nonconvulsive status epilepticus",
"drug": "ifosfamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.",
"role": "user"
},
{
"content": "[{'ade': 'nonconvulsive status epilepticus', 'drug': 'ifosfamide'}]",
"role": "assistant"
}
] |
Phenolphthalein-induced toxic epidermal necrolysis.
|
[
{
"ade": "toxic epidermal necrolysis",
"drug": "Phenolphthalein"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Phenolphthalein-induced toxic epidermal necrolysis.",
"role": "user"
},
{
"content": "[{'ade': 'toxic epidermal necrolysis', 'drug': 'Phenolphthalein'}]",
"role": "assistant"
}
] |
The ampicillin rash occurring in cases of infectious mononucleosis is well documented.
|
[
{
"ade": "ampicillin rash",
"drug": "ampicillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The ampicillin rash occurring in cases of infectious mononucleosis is well documented.",
"role": "user"
},
{
"content": "[{'ade': 'ampicillin rash', 'drug': 'ampicillin'}]",
"role": "assistant"
}
] |
We also describe a case of timolol-induced ocular pemphigoid.
|
[
{
"ade": "ocular pemphigoid",
"drug": "timolol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We also describe a case of timolol-induced ocular pemphigoid.",
"role": "user"
},
{
"content": "[{'ade': 'ocular pemphigoid', 'drug': 'timolol'}]",
"role": "assistant"
}
] |
Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.
|
[
{
"ade": "Traumatic late flap dehiscence",
"drug": "LASIK"
},
{
"ade": "Enterobacter keratitis",
"drug": "LASIK"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.",
"role": "user"
},
{
"content": "[{'ade': 'Traumatic late flap dehiscence', 'drug': 'LASIK'}, {'ade': 'Enterobacter keratitis', 'drug': 'LASIK'}]",
"role": "assistant"
}
] |
Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.
|
[
{
"ade": "PPE",
"drug": "cytarabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.",
"role": "user"
},
{
"content": "[{'ade': 'PPE', 'drug': 'cytarabine'}]",
"role": "assistant"
}
] |
After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.
|
[
{
"ade": "polyneuropathy",
"drug": "5-ASA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.",
"role": "user"
},
{
"content": "[{'ade': 'polyneuropathy', 'drug': '5-ASA'}]",
"role": "assistant"
}
] |
Additionally, danazol produces hepatocellular damage in approximately 10% of women.
|
[
{
"ade": "hepatocellular damage",
"drug": "danazol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Additionally, danazol produces hepatocellular damage in approximately 10% of women.",
"role": "user"
},
{
"content": "[{'ade': 'hepatocellular damage', 'drug': 'danazol'}]",
"role": "assistant"
}
] |
There is no consensus on the treatment of ticlopidine-induced marrow aplasia.
|
[
{
"ade": "marrow aplasia",
"drug": "ticlopidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: There is no consensus on the treatment of ticlopidine-induced marrow aplasia.",
"role": "user"
},
{
"content": "[{'ade': 'marrow aplasia', 'drug': 'ticlopidine'}]",
"role": "assistant"
}
] |
Piloerection induced by replacing fluvoxamine with milnacipran.
|
[
{
"ade": "Piloerection",
"drug": "fluvoxamine"
},
{
"ade": "Piloerection",
"drug": "milnacipran"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Piloerection induced by replacing fluvoxamine with milnacipran.",
"role": "user"
},
{
"content": "[{'ade': 'Piloerection', 'drug': 'fluvoxamine'}, {'ade': 'Piloerection', 'drug': 'milnacipran'}]",
"role": "assistant"
}
] |
We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.
|
[
{
"ade": "bilateral optic neuropathy",
"drug": "ethambutol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.",
"role": "user"
},
{
"content": "[{'ade': 'bilateral optic neuropathy', 'drug': 'ethambutol'}]",
"role": "assistant"
}
] |
We report a case of pediatric bupropion ingestion resulting in multiple seizures.
|
[
{
"ade": "multiple seizures",
"drug": "bupropion"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of pediatric bupropion ingestion resulting in multiple seizures.",
"role": "user"
},
{
"content": "[{'ade': 'multiple seizures', 'drug': 'bupropion'}]",
"role": "assistant"
}
] |
Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.
|
[
{
"ade": "Lethal anuria",
"drug": "ifosfamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.",
"role": "user"
},
{
"content": "[{'ade': 'Lethal anuria', 'drug': 'ifosfamide'}]",
"role": "assistant"
}
] |
Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.
|
[
{
"ade": "Lichen planus",
"drug": "hepatitis B vaccination"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.",
"role": "user"
},
{
"content": "[{'ade': 'Lichen planus', 'drug': 'hepatitis B vaccination'}]",
"role": "assistant"
}
] |
Paraplegia following intrathecal cytosine arabinoside.
|
[
{
"ade": "Paraplegia",
"drug": "cytosine arabinoside"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Paraplegia following intrathecal cytosine arabinoside.",
"role": "user"
},
{
"content": "[{'ade': 'Paraplegia', 'drug': 'cytosine arabinoside'}]",
"role": "assistant"
}
] |
Primary central nervous system lymphoma in a patient treated with natalizumab.
|
[
{
"ade": "Primary central nervous system lymphoma",
"drug": "natalizumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Primary central nervous system lymphoma in a patient treated with natalizumab.",
"role": "user"
},
{
"content": "[{'ade': 'Primary central nervous system lymphoma', 'drug': 'natalizumab'}]",
"role": "assistant"
}
] |
Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.
|
[
{
"ade": "pulmonary toxicity",
"drug": "MTX"
},
{
"ade": "pneumonitis",
"drug": "MTX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.",
"role": "user"
},
{
"content": "[{'ade': 'pulmonary toxicity', 'drug': 'MTX'}, {'ade': 'pneumonitis', 'drug': 'MTX'}]",
"role": "assistant"
}
] |
At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.
|
[
{
"ade": "pain",
"drug": "sunitinib"
},
{
"ade": "development of abnormally large mammary glands",
"drug": "sunitinib"
},
{
"ade": "peri-areolar erythema",
"drug": "sunitinib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.",
"role": "user"
},
{
"content": "[{'ade': 'pain', 'drug': 'sunitinib'}, {'ade': 'development of abnormally large mammary glands', 'drug': 'sunitinib'}, {'ade': 'peri-areolar erythema', 'drug': 'sunitinib'}]",
"role": "assistant"
}
] |
A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.
|
[
{
"ade": "hematochezia",
"drug": "warfarin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.",
"role": "user"
},
{
"content": "[{'ade': 'hematochezia', 'drug': 'warfarin'}]",
"role": "assistant"
}
] |
Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.
|
[
{
"ade": "thrombocytopenia",
"drug": "heparin"
},
{
"ade": "Massive pulmonary embolism",
"drug": "heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'heparin'}, {'ade': 'Massive pulmonary embolism', 'drug': 'heparin'}]",
"role": "assistant"
}
] |
Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.
|
[
{
"ade": "Portal vein thrombosis",
"drug": "F VIII"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Portal vein thrombosis', 'drug': 'F VIII'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.
|
[
{
"ade": "Spontaneous hemothorax",
"drug": "LMWH"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.",
"role": "user"
},
{
"content": "[{'ade': 'Spontaneous hemothorax', 'drug': 'LMWH'}]",
"role": "assistant"
}
] |
We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.
|
[
{
"ade": "fatal intravascular autoimmune hemolytic anemia",
"drug": "fludarabine"
},
{
"ade": "AIHA",
"drug": "fludarabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.",
"role": "user"
},
{
"content": "[{'ade': 'fatal intravascular autoimmune hemolytic anemia', 'drug': 'fludarabine'}, {'ade': 'AIHA', 'drug': 'fludarabine'}]",
"role": "assistant"
}
] |
Photo-onycholysis caused by olanzapine and aripiprazole.
|
[
{
"ade": "Photo-onycholysis",
"drug": "olanzapine"
},
{
"ade": "Photo-onycholysis",
"drug": "aripiprazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Photo-onycholysis caused by olanzapine and aripiprazole.",
"role": "user"
},
{
"content": "[{'ade': 'Photo-onycholysis', 'drug': 'olanzapine'}, {'ade': 'Photo-onycholysis', 'drug': 'aripiprazole'}]",
"role": "assistant"
}
] |
Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.
|
[
{
"ade": "bronchospasm",
"drug": "Zoledronic acid"
},
{
"ade": "carpopedal spasm",
"drug": "Zoledronic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.",
"role": "user"
},
{
"content": "[{'ade': 'bronchospasm', 'drug': 'Zoledronic acid'}, {'ade': 'carpopedal spasm', 'drug': 'Zoledronic acid'}]",
"role": "assistant"
}
] |
The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.
|
[
{
"ade": "TEN",
"drug": "TMP-Sx"
},
{
"ade": "SJS",
"drug": "TMP-Sx"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.",
"role": "user"
},
{
"content": "[{'ade': 'TEN', 'drug': 'TMP-Sx'}, {'ade': 'SJS', 'drug': 'TMP-Sx'}]",
"role": "assistant"
}
] |
Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.
|
[
{
"ade": "Nephrogenic diabetes insipidus",
"drug": "lithium"
},
{
"ade": "NDI",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.",
"role": "user"
},
{
"content": "[{'ade': 'Nephrogenic diabetes insipidus', 'drug': 'lithium'}, {'ade': 'NDI', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.
|
[
{
"ade": "metastatic nodules",
"drug": "cyclophosphamide"
},
{
"ade": "metastatic nodules",
"drug": "Bleomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.",
"role": "user"
},
{
"content": "[{'ade': 'metastatic nodules', 'drug': 'cyclophosphamide'}, {'ade': 'metastatic nodules', 'drug': 'Bleomycin'}]",
"role": "assistant"
}
] |
A new type of minocycline-induced cutaneous hyperpigmentation.
|
[
{
"ade": "cutaneous hyperpigmentation",
"drug": "minocycline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A new type of minocycline-induced cutaneous hyperpigmentation.",
"role": "user"
},
{
"content": "[{'ade': 'cutaneous hyperpigmentation', 'drug': 'minocycline'}]",
"role": "assistant"
}
] |
So far, few cases of pulmonary side effects caused by ticlopidine have been reported.
|
[
{
"ade": "pulmonary side effects",
"drug": "ticlopidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: So far, few cases of pulmonary side effects caused by ticlopidine have been reported.",
"role": "user"
},
{
"content": "[{'ade': 'pulmonary side effects', 'drug': 'ticlopidine'}]",
"role": "assistant"
}
] |
As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.
|
[
{
"ade": "hypersensitivity response",
"drug": "tuberculin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity response', 'drug': 'tuberculin'}]",
"role": "assistant"
}
] |
The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.
|
[
{
"ade": "soft-tissue injury",
"drug": "phenytoin"
},
{
"ade": "purple glove syndrome",
"drug": "phenytoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'soft-tissue injury', 'drug': 'phenytoin'}, {'ade': 'purple glove syndrome', 'drug': 'phenytoin'}]",
"role": "assistant"
}
] |
After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.
|
[
{
"ade": "hepatitis",
"drug": "pegvisomant"
},
{
"ade": "hepatic enzyme disturbances",
"drug": "pegvisomant"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.",
"role": "user"
},
{
"content": "[{'ade': 'hepatitis', 'drug': 'pegvisomant'}, {'ade': 'hepatic enzyme disturbances', 'drug': 'pegvisomant'}]",
"role": "assistant"
}
] |
This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy.
|
[
{
"ade": "fatal encephalopathy",
"drug": "methotrexate"
},
{
"ade": "mild neurotoxicity",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy.",
"role": "user"
},
{
"content": "[{'ade': 'fatal encephalopathy', 'drug': 'methotrexate'}, {'ade': 'mild neurotoxicity', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.
|
[
{
"ade": "sarcoidosis",
"drug": "ribavirin"
},
{
"ade": "sarcoidosis",
"drug": "interferon alpha 2b"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.",
"role": "user"
},
{
"content": "[{'ade': 'sarcoidosis', 'drug': 'ribavirin'}, {'ade': 'sarcoidosis', 'drug': 'interferon alpha 2b'}]",
"role": "assistant"
}
] |
Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.
|
[
{
"ade": "Agranulocytosis",
"drug": "vancomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.",
"role": "user"
},
{
"content": "[{'ade': 'Agranulocytosis', 'drug': 'vancomycin'}]",
"role": "assistant"
}
] |
Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.
|
[
{
"ade": "chest tightness",
"drug": "citalopram"
},
{
"ade": "dizziness",
"drug": "citalopram"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.",
"role": "user"
},
{
"content": "[{'ade': 'chest tightness', 'drug': 'citalopram'}, {'ade': 'dizziness', 'drug': 'citalopram'}]",
"role": "assistant"
}
] |
While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.
|
[
{
"ade": "changes in serotonergic or noradrenergic neurotransmission",
"drug": "IFN-alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.",
"role": "user"
},
{
"content": "[{'ade': 'changes in serotonergic or noradrenergic neurotransmission', 'drug': 'IFN-alpha'}]",
"role": "assistant"
}
] |
This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.
|
[
{
"ade": "severe rash",
"drug": "oxcarbazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.",
"role": "user"
},
{
"content": "[{'ade': 'severe rash', 'drug': 'oxcarbazepine'}]",
"role": "assistant"
}
] |
Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.
|
[
{
"ade": "Reversible heart failure",
"drug": "etanercept"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.",
"role": "user"
},
{
"content": "[{'ade': 'Reversible heart failure', 'drug': 'etanercept'}]",
"role": "assistant"
}
] |
A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.
|
[
{
"ade": "complete atrioventricular block",
"drug": "digoxin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.",
"role": "user"
},
{
"content": "[{'ade': 'complete atrioventricular block', 'drug': 'digoxin'}]",
"role": "assistant"
}
] |
Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.
|
[
{
"ade": "C. difficile colitis",
"drug": "cisplatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.",
"role": "user"
},
{
"content": "[{'ade': 'C. difficile colitis', 'drug': 'cisplatin'}]",
"role": "assistant"
}
] |
Metoclopramide-induced parkinsonism.
|
[
{
"ade": "parkinsonism",
"drug": "Metoclopramide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Metoclopramide-induced parkinsonism.",
"role": "user"
},
{
"content": "[{'ade': 'parkinsonism', 'drug': 'Metoclopramide'}]",
"role": "assistant"
}
] |
Acne provoked by gold seems not to have been described elsewhere.
|
[
{
"ade": "Acne",
"drug": "gold"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acne provoked by gold seems not to have been described elsewhere.",
"role": "user"
},
{
"content": "[{'ade': 'Acne', 'drug': 'gold'}]",
"role": "assistant"
}
] |
A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor.
|
[
{
"ade": "TEN",
"drug": "lamotrigine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor.",
"role": "user"
},
{
"content": "[{'ade': 'TEN', 'drug': 'lamotrigine'}]",
"role": "assistant"
}
] |
Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.
|
[
{
"ade": "seizures",
"drug": "methylprednisolone"
},
{
"ade": "transient blindness",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.",
"role": "user"
},
{
"content": "[{'ade': 'seizures', 'drug': 'methylprednisolone'}, {'ade': 'transient blindness', 'drug': 'methylprednisolone'}]",
"role": "assistant"
}
] |
A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.
|
[
{
"ade": "miliary tuberculosis",
"drug": "metformin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.",
"role": "user"
},
{
"content": "[{'ade': 'miliary tuberculosis', 'drug': 'metformin'}]",
"role": "assistant"
}
] |
Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.
|
[
{
"ade": "altered mental status",
"drug": "valproic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.",
"role": "user"
},
{
"content": "[{'ade': 'altered mental status', 'drug': 'valproic acid'}]",
"role": "assistant"
}
] |
Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.
|
[
{
"ade": "aggravation of nonalcoholic steatohepatitis",
"drug": "raloxifene"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.",
"role": "user"
},
{
"content": "[{'ade': 'aggravation of nonalcoholic steatohepatitis', 'drug': 'raloxifene'}]",
"role": "assistant"
}
] |
Nitrendipine-induced gingival hyperplasia.
|
[
{
"ade": "gingival hyperplasia",
"drug": "Nitrendipine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nitrendipine-induced gingival hyperplasia.",
"role": "user"
},
{
"content": "[{'ade': 'gingival hyperplasia', 'drug': 'Nitrendipine'}]",
"role": "assistant"
}
] |
OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.
|
[
{
"ade": "severe chloroquine toxicity",
"drug": "chloroquine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.",
"role": "user"
},
{
"content": "[{'ade': 'severe chloroquine toxicity', 'drug': 'chloroquine'}]",
"role": "assistant"
}
] |
Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.
|
[
{
"ade": "Methanol toxicity",
"drug": "Methanol"
},
{
"ade": "severe central nervous system insult",
"drug": "Methanol"
},
{
"ade": "bilateral putaminal injury",
"drug": "Methanol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.",
"role": "user"
},
{
"content": "[{'ade': 'Methanol toxicity', 'drug': 'Methanol'}, {'ade': 'severe central nervous system insult', 'drug': 'Methanol'}, {'ade': 'bilateral putaminal injury', 'drug': 'Methanol'}]",
"role": "assistant"
}
] |
This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine.
|
[
{
"ade": "hemophagocytic syndrome",
"drug": "sulfasalazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine.",
"role": "user"
},
{
"content": "[{'ade': 'hemophagocytic syndrome', 'drug': 'sulfasalazine'}]",
"role": "assistant"
}
] |
PURPOSE: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.
|
[
{
"ade": "acute endophthalmitis",
"drug": "bevacizumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PURPOSE: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.",
"role": "user"
},
{
"content": "[{'ade': 'acute endophthalmitis', 'drug': 'bevacizumab'}]",
"role": "assistant"
}
] |
Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature.
|
[
{
"ade": "Erythema multiforme",
"drug": "phenytoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature.",
"role": "user"
},
{
"content": "[{'ade': 'Erythema multiforme', 'drug': 'phenytoin'}]",
"role": "assistant"
}
] |
The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.
|
[
{
"ade": "diffuse subfascial hematoma",
"drug": "alteplase"
},
{
"ade": "cutaneous ecchymosis",
"drug": "alteplase"
},
{
"ade": "sudden fall in hemoglobin",
"drug": "alteplase"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.",
"role": "user"
},
{
"content": "[{'ade': 'diffuse subfascial hematoma', 'drug': 'alteplase'}, {'ade': 'cutaneous ecchymosis', 'drug': 'alteplase'}, {'ade': 'sudden fall in hemoglobin', 'drug': 'alteplase'}]",
"role": "assistant"
}
] |
We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).
|
[
{
"ade": "GPP",
"drug": "Molipaxin"
},
{
"ade": "generalized pustular psoriasis",
"drug": "Molipaxin"
},
{
"ade": "GPP",
"drug": "trazodone hydrochloride"
},
{
"ade": "generalized pustular psoriasis",
"drug": "trazodone hydrochloride"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).",
"role": "user"
},
{
"content": "[{'ade': 'GPP', 'drug': 'Molipaxin'}, {'ade': 'generalized pustular psoriasis', 'drug': 'Molipaxin'}, {'ade': 'GPP', 'drug': 'trazodone hydrochloride'}, {'ade': 'generalized pustular psoriasis', 'drug': 'trazodone hydrochloride'}]",
"role": "assistant"
}
] |
A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.
|
[
{
"ade": "hepatic dysfunction",
"drug": "perhexiline maleate"
},
{
"ade": "papilloedema",
"drug": "perhexiline maleate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.",
"role": "user"
},
{
"content": "[{'ade': 'hepatic dysfunction', 'drug': 'perhexiline maleate'}, {'ade': 'papilloedema', 'drug': 'perhexiline maleate'}]",
"role": "assistant"
}
] |
Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus.
|
[
{
"ade": "Reflex sympathetic dystrophy syndrome",
"drug": "tacrolimus"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus.",
"role": "user"
},
{
"content": "[{'ade': 'Reflex sympathetic dystrophy syndrome', 'drug': 'tacrolimus'}]",
"role": "assistant"
}
] |
Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.
|
[
{
"ade": "Imidazoline intoxication",
"drug": "Imidazoline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.",
"role": "user"
},
{
"content": "[{'ade': 'Imidazoline intoxication', 'drug': 'Imidazoline'}]",
"role": "assistant"
}
] |
Allergic contact dermatitis to compound tincture of benzoin.
|
[
{
"ade": "Allergic contact dermatitis",
"drug": "benzoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Allergic contact dermatitis to compound tincture of benzoin.",
"role": "user"
},
{
"content": "[{'ade': 'Allergic contact dermatitis', 'drug': 'benzoin'}]",
"role": "assistant"
}
] |
The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.
|
[
{
"ade": "renal deterioration",
"drug": "cefuroxime"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.",
"role": "user"
},
{
"content": "[{'ade': 'renal deterioration', 'drug': 'cefuroxime'}]",
"role": "assistant"
}
] |
Cephalosporin-induced leukopenia following rechallenge with cefoxitin.
|
[
{
"ade": "leukopenia",
"drug": "Cephalosporin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cephalosporin-induced leukopenia following rechallenge with cefoxitin.",
"role": "user"
},
{
"content": "[{'ade': 'leukopenia', 'drug': 'Cephalosporin'}]",
"role": "assistant"
}
] |
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