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Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.	[ { "ade": "Skin necrosis", "drug": "heparin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.", "role": "user" ...
A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).	[ { "ade": "AVT", "drug": "quinidine" }, { "ade": "AVT", "drug": "disopyramide" }, { "ade": "torsade de pointes", "drug": "quinidine" }, { "ade": "atypical ventricular tachycardia", "drug": "quinidine" }, { "ade": "AVT", "drug": "amiodarone" }, { "ade": ...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical v...
A patient with severe cholestatic jaundice induced by captopril is presented.	[ { "ade": "severe cholestatic jaundice", "drug": "captopril" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient with severe cholestatic jaundice induced by captopril is presented.", "role": "user" }, { "content": "[{'ade'...
Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.	[ { "ade": "flare-up", "drug": "goserelin acetate" }, { "ade": "worsening pleuritis carcinomatosa", "drug": "goserelin acetate" }, { "ade": "severe dyspnea", "drug": "goserelin acetate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinoma...
After stopping indapamide, glucose tolerance impairing may be reversed.	[ { "ade": "glucose tolerance impairing", "drug": "indapamide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After stopping indapamide, glucose tolerance impairing may be reversed.", "role": "user" }, { "content": "[{'ade': 'glu...
Intrathecal methotrexate-induced acute cerebellar syndrome.	[ { "ade": "acute cerebellar syndrome", "drug": "methotrexate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Intrathecal methotrexate-induced acute cerebellar syndrome.", "role": "user" }, { "content": "[{'ade': 'acute cerebella...
We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.	[ { "ade": "parkinsonism", "drug": "metoclopramide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.", "role": "user"...
Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.	[ { "ade": "myocardial ischemia", "drug": "BCNU" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial i...
Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.	[ { "ade": "thrombocytopenia", "drug": "IFN" }, { "ade": "hypoalbuminemia", "drug": "IFN" }, { "ade": "ocular side effects", "drug": "IFN" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurren...
Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.	[ { "ade": "multiple skin cancers", "drug": "hydroxyurea" }, { "ade": "longitudinal melanonychia", "drug": "hydroxyurea" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatme...
Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.	[ { "ade": "cortical negative myoclonus", "drug": "pregabalin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.", ...
The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.	[ { "ade": "grand mal seizure", "drug": "propranolol" }, { "ade": "photosensitivity", "drug": "propranolol" }, { "ade": "delirium", "drug": "propranolol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the...
Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.	[ { "ade": "anaphylaxis", "drug": "methotrexate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylax...
Amphotericin B nephrotoxicity in humans decreased by salt repletion.	[ { "ade": "nephrotoxicity", "drug": "Amphotericin B" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Amphotericin B nephrotoxicity in humans decreased by salt repletion.", "role": "user" }, { "content": "[{'ade': 'nephro...
Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.	[ { "ade": "hepatotoxicity", "drug": "amiodarone" }, { "ade": "aggravation of arrhythmia", "drug": "amiodarone" }, { "ade": "pulmonary toxicity", "drug": "amiodarone" }, { "ade": "thyroid diseases", "drug": "amiodarone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are wel...
A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.	[ { "ade": "angio-oedema", "drug": "irbesartan" }, { "ade": "hypotensive shock", "drug": "irbesartan" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenalin...
In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.	[ { "ade": "cutaneous herpes zoster", "drug": "cytarabine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after adminis...
We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.	[ { "ade": "choroidal detachment", "drug": "dorzolamide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically unt...
After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.	[ { "ade": "blindness", "drug": "lithium" }, { "ade": "CPM", "drug": "lithium" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucl...
The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS).	[ { "ade": "thrombosis syndrome", "drug": "heparin" }, { "ade": "thrombocytopenia", "drug": "heparin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thro...
Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.	[ { "ade": "Delayed pseudocyst of the pancreas", "drug": "L-asparaginase" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.", "role": "user" }, { "conten...
Captopril-induced acute reversible renal failure.	[ { "ade": "acute reversible renal failure", "drug": "Captopril" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Captopril-induced acute reversible renal failure.", "role": "user" }, { "content": "[{'ade': 'acute reversible renal fa...
Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.	[ { "ade": "neurologic toxic effects", "drug": "Sulindac" }, { "ade": "neurologic toxic effects", "drug": "Clinoril" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been asso...
Acute leukopenia associated with silver sulfadiazine therapy.	[ { "ade": "Acute leukopenia", "drug": "silver sulfadiazine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute leukopenia associated with silver sulfadiazine therapy.", "role": "user" }, { "content": "[{'ade': 'Acute leukope...
Intranasal desmopressin-induced hyponatremia.	[ { "ade": "hyponatremia", "drug": "desmopressin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Intranasal desmopressin-induced hyponatremia.", "role": "user" }, { "content": "[{'ade': 'hyponatremia', 'drug': 'desmo...
While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.	[ { "ade": "renal failure", "drug": "dextran" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.", "rol...
Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.	[ { "ade": "cicatricial entropion", "drug": "dipivefrin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at l...
Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.	[ { "ade": "Methemoglobinemia", "drug": "dapsone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent sympto...
Isoniazid and ethambutol as a cause of optic neuropathy.	[ { "ade": "optic neuropathy", "drug": "Isoniazid" }, { "ade": "optic neuropathy", "drug": "ethambutol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Isoniazid and ethambutol as a cause of optic neuropathy.", "role": "user" }, { "content": "[{'ade': 'optic neuropathy',...
We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.	[ { "ade": "ARDS", "drug": "pegylated interferon alpha-2a" }, { "ade": "ARDS", "drug": "pegIFNalpha-2a" }, { "ade": "ARDS", "drug": "ribavirin" }, { "ade": "adult respiratory distress syndrome", "drug": "ribavirin" }, { "ade": "adult respiratory distress syndrome", ...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (peg...
OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.	[ { "ade": "lipoatrophies", "drug": "insulin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutan...
Nephropathy caused by methicillin therapy for staphylococcal septicemia.	[ { "ade": "Nephropathy", "drug": "methicillin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nephropathy caused by methicillin therapy for staphylococcal septicemia.", "role": "user" }, { "content": "[{'ade': 'Ne...
PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.	[ { "ade": "glaucoma", "drug": "triamcinolone acetate" }, { "ade": "glaucoma", "drug": "corticosteroid" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-y...
Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.	[ { "ade": "hypersensitivity syndrome", "drug": "carbamazepine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine a...
In these patients, long-acting octreotide may trigger serious hypoglycemia.	[ { "ade": "serious hypoglycemia", "drug": "octreotide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In these patients, long-acting octreotide may trigger serious hypoglycemia.", "role": "user" }, { "content": "[{'ade': ...
This is the first report of UFT-induced scleroderma-like reaction.	[ { "ade": "UFT-induced scleroderma-like reaction", "drug": "UFT" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the first report of UFT-induced scleroderma-like reaction.", "role": "user" }, { "content": "[{'ade': 'UFT-indu...
We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.	[ { "ade": "penile fibrosis", "drug": "papaverine" }, { "ade": "penile fibrosis", "drug": "phentolamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.", "rol...
CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.	[ { "ade": "nonconvulsive status epilepticus", "drug": "ifosfamide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide i...
Phenolphthalein-induced toxic epidermal necrolysis.	[ { "ade": "toxic epidermal necrolysis", "drug": "Phenolphthalein" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Phenolphthalein-induced toxic epidermal necrolysis.", "role": "user" }, { "content": "[{'ade': 'toxic epidermal necroly...
The ampicillin rash occurring in cases of infectious mononucleosis is well documented.	[ { "ade": "ampicillin rash", "drug": "ampicillin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The ampicillin rash occurring in cases of infectious mononucleosis is well documented.", "role": "user" }, { "content":...