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This is the first histologically confirmed case of NASH that was aggravated by raloxifene.	[ { "ade": "NASH", "drug": "raloxifene" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the first histologically confirmed case of NASH that was aggravated by raloxifene.", "role": "user" }, { "conte...
Allergic and irritant contact dermatitis to calcipotriol.	[ { "ade": "irritant contact dermatitis", "drug": "calcipotriol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Allergic and irritant contact dermatitis to calcipotriol.", "role": "user" }, { "content": "[{'ade': 'irritant contact ...
We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.	[ { "ade": "cardiac toxicity", "drug": "diphenhydramine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.", "role": "user" }, { ...
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.	[ { "ade": "tremulous", "drug": "clozapine" }, { "ade": "shivering", "drug": "clozapine" }, { "ade": "shivering", "drug": "clomipramine" }, { "ade": "tremulous", "drug": "clomipramine" }, { "ade": "agitated", "drug": "clozapine" }, { "ade": "behaving odd...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating ...
Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).	[ { "ade": "Systemic capillary leak syndrome", "drug": "granulocyte colony-stimulating factor" }, { "ade": "Systemic capillary leak syndrome", "drug": "G-CSF" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).", "role": "user" }, { "content": ...
We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP).	[ { "ade": "bronchiolitis obliterans with organizing pneumonia", "drug": "rituximab" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obl...
Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.	[ { "ade": "gastrointestinal adverse reactions", "drug": "Ibuprofen" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in pati...
CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.	[ { "ade": "DAT-positive hemolytic episode", "drug": "oxaliplatin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered du...
Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.	[ { "ade": "carcinoma of the corpus uteri", "drug": "tamoxifen" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of...
In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.	[ { "ade": "visual loss", "drug": "ethambutol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.", "role": "user" }, ...
Clinical signs of hypermagnesemia are an uncommon complication following oral administration of magnesium sulfate.	[ { "ade": "hypermagnesemia", "drug": "magnesium sulfate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Clinical signs of hypermagnesemia are an uncommon complication following oral administration of magnesium sulfate.", "role": "u...
Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomylysis.	[ { "ade": "rhabdomylysis", "drug": "colchicine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and b...
Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.	[ { "ade": "pseudomembranous colitis", "drug": "trimethoprim" }, { "ade": "colitis", "drug": "trimethoprim" }, { "ade": "colitis", "drug": "sulfamethoxazole" }, { "ade": "pseudomembranous colitis", "drug": "sulfamethoxazole" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimeth...
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity.	[ { "ade": "osteonecrosis of the jaw", "drug": "Bisphosphonate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphon...
We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.	[ { "ade": "dapsone reaction", "drug": "dapsone" }, { "ade": "fatal", "drug": "dapsone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fata...
Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.	[ { "ade": "severe neutropenia", "drug": "olanzapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.", "role": "user" }...
A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.	[ { "ade": "glycosuria", "drug": "halcinonide" }, { "ade": "postprandial hyperglycemia", "drug": "halcinonide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes...
Didanosine also has a potential for inducing seizures.	[ { "ade": "seizures", "drug": "Didanosine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Didanosine also has a potential for inducing seizures.", "role": "user" }, { "content": "[{'ade': 'seizures', 'drug': '...
Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.	[ { "ade": "Acute erythroid leukemia", "drug": "cyclophosphamide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.", "role": "user" }, { ...
This was accepted as evidence for propranolol being the cause of this conduction disorder.	[ { "ade": "conduction disorder", "drug": "propranolol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This was accepted as evidence for propranolol being the cause of this conduction disorder.", "role": "user" }, { "conte...
Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.	[ { "ade": "Fatal interstitial pneumonitis", "drug": "chlorambucil" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.", "role":...
CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.	[ { "ade": "serotonin syndrome", "drug": "venlafaxine" }, { "ade": "extrapyramidal reactions", "drug": "sertraline" }, { "ade": "extrapyramidal reactions", "drug": "venlafaxine" }, { "ade": "extrapyramidal reactions", "drug": "metoclopramide" }, { "ade": "serotonin ...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving...
A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment.	[ { "ade": "symmetric sensorimotor polyneuropathy", "drug": "amiodarone" }, { "ade": "cerebellar syndrome", "drug": "amiodarone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment...
This report describes a case of bilateral ptosis induced by chloroquine.	[ { "ade": "bilateral ptosis", "drug": "chloroquine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report describes a case of bilateral ptosis induced by chloroquine.", "role": "user" }, { "content": "[{'ade': 'bi...
We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.	[ { "ade": "hypersensitivity", "drug": "carboplatin" }, { "ade": "hypersensitivity", "drug": "CBDCA" }, { "ade": "hypersensitivity", "drug": "paclitaxel" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the conc...
Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline.	[ { "ade": "dacryolith", "drug": "adrenaline" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline.", "role": "user" }...
Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.	[ { "ade": "PV", "drug": "penicillamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicill...
5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.	[ { "ade": "peripheral neuropathy", "drug": "5-fluorouracil" }, { "ade": "peripheral neuropathy", "drug": "5-FU" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: 5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.", "role": "user" }, { "content": "[{'ade':...
The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.	[ { "ade": "reversible hearing loss", "drug": "quinine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is p...
It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in these patients.	[ { "ade": "osteonecrosis", "drug": "dexamethasone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in the...
Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.	[ { "ade": "Peripheral neuropathy", "drug": "amiodarone" }, { "ade": "cerebellar syndrome", "drug": "amiodarone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.", "role": "user" }, { "content": "[{'...
Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss.	[ { "ade": "progressive sensorineural hearing loss", "drug": "cisplatin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss.", "role": ...
Reversible cholestasis with bile duct injury following azathioprine therapy.	[ { "ade": "cholestasis", "drug": "azathioprine" }, { "ade": "bile duct injury", "drug": "azathioprine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reversible cholestasis with bile duct injury following azathioprine therapy.", "role": "user" }, { "content": "[{'ade':...
Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur.	[ { "ade": "cutaneous side-effects", "drug": "Captopril" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been ...
Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.	[ { "ade": "Cushing's syndrome", "drug": "TCA" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.", "role"...
This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.	[ { "ade": "hypophosphatemia", "drug": "Fosamax" }, { "ade": "hypophosphatemia", "drug": "Fleet Phospho-Soda" }, { "ade": "hypocalcemic tetany", "drug": "alendronate" }, { "ade": "hypocalcemic tetany", "drug": "Fosamax" }, { "ade": "hypophosphatemia", "drug": "a...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosp...
BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.	[ { "ade": "Ovarian cancer", "drug": "tamoxifen" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.", "rol...
A case of fluoxetine induced seizures, in a person with Down syndrome, is described.	[ { "ade": "seizures", "drug": "fluoxetine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of fluoxetine induced seizures, in a person with Down syndrome, is described.", "role": "user" }, { "content": "...
A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.	[ { "ade": "movement disorder", "drug": "trazodone" }, { "ade": "movement disorder", "drug": "lithium" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a...
These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).	[ { "ade": "skin lesions", "drug": "IFN" }, { "ade": "skin lesions", "drug": "interferon-alpha" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).", "role": "user" }, { ...