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RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.
|
[
{
"ade": "increased libido",
"drug": "fluvoxamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.",
"role": "user"
},
{
"content": "[{'ade': 'increased libido', 'drug': 'fluvoxamine'}]",
"role": "assistant"
}
] |
Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.
|
[
{
"ade": "toxic epidermal necrolysis",
"drug": "Levofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.",
"role": "user"
},
{
"content": "[{'ade': 'toxic epidermal necrolysis', 'drug': 'Levofloxacin'}]",
"role": "assistant"
}
] |
Cimetidine-induced fever.
|
[
{
"ade": "fever",
"drug": "Cimetidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cimetidine-induced fever.",
"role": "user"
},
{
"content": "[{'ade': 'fever', 'drug': 'Cimetidine'}]",
"role": "assistant"
}
] |
Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.
|
[
{
"ade": "acute myeloid leukemia",
"drug": "etoposide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.",
"role": "user"
},
{
"content": "[{'ade': 'acute myeloid leukemia', 'drug': 'etoposide'}]",
"role": "assistant"
}
] |
The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.
|
[
{
"ade": "subacute interstitial pneumonitis-related pulmonary fibrosis",
"drug": "docetaxel"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.",
"role": "user"
},
{
"content": "[{'ade': 'subacute interstitial pneumonitis-related pulmonary fibrosis', 'drug': 'docetaxel'}]",
"role": "assistant"
}
] |
The patient continued to have fever and autonomic instability without evidence of infection which entirely resolved within 24 hours of reinstitution of full preadmission dosing of oral baclofen.
|
[
{
"ade": "autonomic instability",
"drug": "baclofen"
},
{
"ade": "fever",
"drug": "baclofen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient continued to have fever and autonomic instability without evidence of infection which entirely resolved within 24 hours of reinstitution of full preadmission dosing of oral baclofen.",
"role": "user"
},
{
"content": "[{'ade': 'autonomic instability', 'drug': 'baclofen'}, {'ade': 'fever', 'drug': 'baclofen'}]",
"role": "assistant"
}
] |
The exact mechanism of IVIG-associated acute renal failure remains unclear.
|
[
{
"ade": "acute renal failure",
"drug": "IVIG"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The exact mechanism of IVIG-associated acute renal failure remains unclear.",
"role": "user"
},
{
"content": "[{'ade': 'acute renal failure', 'drug': 'IVIG'}]",
"role": "assistant"
}
] |
Can magnesium sulfate therapy impact lactogenesis?
|
[
{
"ade": "lactogenesis",
"drug": "magnesium sulfate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Can magnesium sulfate therapy impact lactogenesis?",
"role": "user"
},
{
"content": "[{'ade': 'lactogenesis', 'drug': 'magnesium sulfate'}]",
"role": "assistant"
}
] |
Severe akathisia during olanzapine treatment of acute schizophrenia.
|
[
{
"ade": "Severe akathisia",
"drug": "olanzapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe akathisia during olanzapine treatment of acute schizophrenia.",
"role": "user"
},
{
"content": "[{'ade': 'Severe akathisia', 'drug': 'olanzapine'}]",
"role": "assistant"
}
] |
Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.
|
[
{
"ade": "Accelerated nodulosis",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.",
"role": "user"
},
{
"content": "[{'ade': 'Accelerated nodulosis', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
A syndrome of increased affect in response to risperidone among patients with schizophrenia.
|
[
{
"ade": "syndrome of increased affect",
"drug": "risperidone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A syndrome of increased affect in response to risperidone among patients with schizophrenia.",
"role": "user"
},
{
"content": "[{'ade': 'syndrome of increased affect', 'drug': 'risperidone'}]",
"role": "assistant"
}
] |
Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.
|
[
{
"ade": "extensive skin rash",
"drug": "MTX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.",
"role": "user"
},
{
"content": "[{'ade': 'extensive skin rash', 'drug': 'MTX'}]",
"role": "assistant"
}
] |
A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.
|
[
{
"ade": "lichen planus",
"drug": "gold"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.",
"role": "user"
},
{
"content": "[{'ade': 'lichen planus', 'drug': 'gold'}]",
"role": "assistant"
}
] |
Losartan-induced angioedema.
|
[
{
"ade": "angioedema",
"drug": "Losartan"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Losartan-induced angioedema.",
"role": "user"
},
{
"content": "[{'ade': 'angioedema', 'drug': 'Losartan'}]",
"role": "assistant"
}
] |
With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.
|
[
{
"ade": "mononucleosis-like syndrome",
"drug": "minocycline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.",
"role": "user"
},
{
"content": "[{'ade': 'mononucleosis-like syndrome', 'drug': 'minocycline'}]",
"role": "assistant"
}
] |
The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.
|
[
{
"ade": "cutaneous vasculitis",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.",
"role": "user"
},
{
"content": "[{'ade': 'cutaneous vasculitis', 'drug': 'propylthiouracil'}]",
"role": "assistant"
}
] |
We describe a patient who became hypothyroid while taking ferrous sulfate.
|
[
{
"ade": "hypothyroid",
"drug": "ferrous sulfate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a patient who became hypothyroid while taking ferrous sulfate.",
"role": "user"
},
{
"content": "[{'ade': 'hypothyroid', 'drug': 'ferrous sulfate'}]",
"role": "assistant"
}
] |
Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.
|
[
{
"ade": "thyroid dysfunctions",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.",
"role": "user"
},
{
"content": "[{'ade': 'thyroid dysfunctions', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.
|
[
{
"ade": "Stuttering priapism",
"drug": "warfarin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.",
"role": "user"
},
{
"content": "[{'ade': 'Stuttering priapism', 'drug': 'warfarin'}]",
"role": "assistant"
}
] |
Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.
|
[
{
"ade": "Hypersensitivity reaction",
"drug": "chloramphenicol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.",
"role": "user"
},
{
"content": "[{'ade': 'Hypersensitivity reaction', 'drug': 'chloramphenicol'}]",
"role": "assistant"
}
] |
Concomitant administration of lithium with olanzapine may place patients at risk for NMS.
|
[
{
"ade": "NMS",
"drug": "olanzapine"
},
{
"ade": "NMS",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Concomitant administration of lithium with olanzapine may place patients at risk for NMS.",
"role": "user"
},
{
"content": "[{'ade': 'NMS', 'drug': 'olanzapine'}, {'ade': 'NMS', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
After five and six weeks of continuous oral administration of methylprednisolone, the boys developed steroid diabetes.
|
[
{
"ade": "steroid diabetes",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After five and six weeks of continuous oral administration of methylprednisolone, the boys developed steroid diabetes.",
"role": "user"
},
{
"content": "[{'ade': 'steroid diabetes', 'drug': 'methylprednisolone'}]",
"role": "assistant"
}
] |
Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.
|
[
{
"ade": "Acute lung injury",
"drug": "oxaliplatinum"
},
{
"ade": "Acute lung injury",
"drug": "5-fluorouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.",
"role": "user"
},
{
"content": "[{'ade': 'Acute lung injury', 'drug': 'oxaliplatinum'}, {'ade': 'Acute lung injury', 'drug': '5-fluorouracil'}]",
"role": "assistant"
}
] |
Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.
|
[
{
"ade": "fibrillation",
"drug": "bretylium"
},
{
"ade": "Paradoxical ventricular tachycardia",
"drug": "bretylium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.",
"role": "user"
},
{
"content": "[{'ade': 'fibrillation', 'drug': 'bretylium'}, {'ade': 'Paradoxical ventricular tachycardia', 'drug': 'bretylium'}]",
"role": "assistant"
}
] |
Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.
|
[
{
"ade": "keratitis",
"drug": "methamphetamine"
},
{
"ade": "toxic effects",
"drug": "methamphetamine"
},
{
"ade": "toxic effects",
"drug": "lidocaine"
},
{
"ade": "keratitis",
"drug": "lidocaine"
},
{
"ade": "keratitis",
"drug": "quinine"
},
{
"ade": "toxic effects",
"drug": "quinine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or \"cutting\" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.",
"role": "user"
},
{
"content": "[{'ade': 'keratitis', 'drug': 'methamphetamine'}, {'ade': 'toxic effects', 'drug': 'methamphetamine'}, {'ade': 'toxic effects', 'drug': 'lidocaine'}, {'ade': 'keratitis', 'drug': 'lidocaine'}, {'ade': 'keratitis', 'drug': 'quinine'}, {'ade': 'toxic effects', 'drug': 'quinine'}]",
"role": "assistant"
}
] |
In the third child, the tics ceased after CBZ discontinuation.
|
[
{
"ade": "tics",
"drug": "CBZ"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In the third child, the tics ceased after CBZ discontinuation.",
"role": "user"
},
{
"content": "[{'ade': 'tics', 'drug': 'CBZ'}]",
"role": "assistant"
}
] |
The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.
|
[
{
"ade": "pro-arrhythmic effects",
"drug": "procainamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.",
"role": "user"
},
{
"content": "[{'ade': 'pro-arrhythmic effects', 'drug': 'procainamide'}]",
"role": "assistant"
}
] |
Atenolol induced memory impairment: a case report.
|
[
{
"ade": "memory impairment",
"drug": "Atenolol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Atenolol induced memory impairment: a case report.",
"role": "user"
},
{
"content": "[{'ade': 'memory impairment', 'drug': 'Atenolol'}]",
"role": "assistant"
}
] |
We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.
|
[
{
"ade": "severe hypertension",
"drug": "phenylephrine"
},
{
"ade": "severe hypertension",
"drug": "epinephrine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.",
"role": "user"
},
{
"content": "[{'ade': 'severe hypertension', 'drug': 'phenylephrine'}, {'ade': 'severe hypertension', 'drug': 'epinephrine'}]",
"role": "assistant"
}
] |
There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.
|
[
{
"ade": "transient myopia",
"drug": "Accutane"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.",
"role": "user"
},
{
"content": "[{'ade': 'transient myopia', 'drug': 'Accutane'}]",
"role": "assistant"
}
] |
Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?
|
[
{
"ade": "skeletal fluorosis",
"drug": "Niflumic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?",
"role": "user"
},
{
"content": "[{'ade': 'skeletal fluorosis', 'drug': 'Niflumic acid'}]",
"role": "assistant"
}
] |
Acute coronary events following cisplatin-based chemotherapy.
|
[
{
"ade": "Acute coronary events",
"drug": "cisplatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute coronary events following cisplatin-based chemotherapy.",
"role": "user"
},
{
"content": "[{'ade': 'Acute coronary events', 'drug': 'cisplatin'}]",
"role": "assistant"
}
] |
A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.
|
[
{
"ade": "polymyositis",
"drug": "interferon alpha"
},
{
"ade": "dilated cardiomyopathy",
"drug": "interferon alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.",
"role": "user"
},
{
"content": "[{'ade': 'polymyositis', 'drug': 'interferon alpha'}, {'ade': 'dilated cardiomyopathy', 'drug': 'interferon alpha'}]",
"role": "assistant"
}
] |
Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.
|
[
{
"ade": "Musculoskeletal complaints",
"drug": "cyclophosphamide"
},
{
"ade": "Musculoskeletal complaints",
"drug": "ifosfamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.",
"role": "user"
},
{
"content": "[{'ade': 'Musculoskeletal complaints', 'drug': 'cyclophosphamide'}, {'ade': 'Musculoskeletal complaints', 'drug': 'ifosfamide'}]",
"role": "assistant"
}
] |
Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis.
|
[
{
"ade": "Posterior reversible encephalopathy syndrome",
"drug": "PRES"
},
{
"ade": "cyclosporine",
"drug": "PRES"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis.",
"role": "user"
},
{
"content": "[{'ade': 'Posterior reversible encephalopathy syndrome', 'drug': 'PRES'}, {'ade': 'cyclosporine', 'drug': 'PRES'}]",
"role": "assistant"
}
] |
Fulminant hepatitis associated with disulfiram.
|
[
{
"ade": "Fulminant hepatitis",
"drug": "disulfiram"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fulminant hepatitis associated with disulfiram.",
"role": "user"
},
{
"content": "[{'ade': 'Fulminant hepatitis', 'drug': 'disulfiram'}]",
"role": "assistant"
}
] |
We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.
|
[
{
"ade": "sensorimotor axonal neuropathy",
"drug": "thalidomide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.",
"role": "user"
},
{
"content": "[{'ade': 'sensorimotor axonal neuropathy', 'drug': 'thalidomide'}]",
"role": "assistant"
}
] |
We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.
|
[
{
"ade": "spontaneous splenic infarction",
"drug": "sumatriptan"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.",
"role": "user"
},
{
"content": "[{'ade': 'spontaneous splenic infarction', 'drug': 'sumatriptan'}]",
"role": "assistant"
}
] |
CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.
|
[
{
"ade": "colchicine intoxication",
"drug": "colchicine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.",
"role": "user"
},
{
"content": "[{'ade': 'colchicine intoxication', 'drug': 'colchicine'}]",
"role": "assistant"
}
] |
After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole.
|
[
{
"ade": "asystole",
"drug": "esmolol hydrochloride"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole.",
"role": "user"
},
{
"content": "[{'ade': 'asystole', 'drug': 'esmolol hydrochloride'}]",
"role": "assistant"
}
] |
Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.
|
[
{
"ade": "renal insufficiency",
"drug": "nimesulide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.",
"role": "user"
},
{
"content": "[{'ade': 'renal insufficiency', 'drug': 'nimesulide'}]",
"role": "assistant"
}
] |
Flucloxacillin-induced aplastic anaemia and liver failure.
|
[
{
"ade": "liver failure",
"drug": "Flucloxacillin"
},
{
"ade": "aplastic anaemia",
"drug": "Flucloxacillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Flucloxacillin-induced aplastic anaemia and liver failure.",
"role": "user"
},
{
"content": "[{'ade': 'liver failure', 'drug': 'Flucloxacillin'}, {'ade': 'aplastic anaemia', 'drug': 'Flucloxacillin'}]",
"role": "assistant"
}
] |
We present the first case (to our knowledge) of a potentially serious drug-drug interaction between zafirlukast and theophylline.
|
[
{
"ade": "drug-drug interaction",
"drug": "zafirlukast"
},
{
"ade": "drug-drug interaction",
"drug": "theophylline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present the first case (to our knowledge) of a potentially serious drug-drug interaction between zafirlukast and theophylline.",
"role": "user"
},
{
"content": "[{'ade': 'drug-drug interaction', 'drug': 'zafirlukast'}, {'ade': 'drug-drug interaction', 'drug': 'theophylline'}]",
"role": "assistant"
}
] |
Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.
|
[
{
"ade": "hypersensitivity syndrome",
"drug": "Carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity syndrome', 'drug': 'Carbamazepine'}]",
"role": "assistant"
}
] |
With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking.
|
[
{
"ade": "hepatotoxic",
"drug": "itraconazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking.",
"role": "user"
},
{
"content": "[{'ade': 'hepatotoxic', 'drug': 'itraconazole'}]",
"role": "assistant"
}
] |
The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.
|
[
{
"ade": "unusual weight fluctuation",
"drug": "aripiprazole"
},
{
"ade": "unusual weight fluctuation",
"drug": "mianserin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.",
"role": "user"
},
{
"content": "[{'ade': 'unusual weight fluctuation', 'drug': 'aripiprazole'}, {'ade': 'unusual weight fluctuation', 'drug': 'mianserin'}]",
"role": "assistant"
}
] |
A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.
|
[
{
"ade": "irreversible lethal renal failure",
"drug": "ifosfamide"
},
{
"ade": "anuria",
"drug": "ifosfamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.",
"role": "user"
},
{
"content": "[{'ade': 'irreversible lethal renal failure', 'drug': 'ifosfamide'}, {'ade': 'anuria', 'drug': 'ifosfamide'}]",
"role": "assistant"
}
] |
Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.
|
[
{
"ade": "Pancreatitis",
"drug": "L-asparaginase"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.",
"role": "user"
},
{
"content": "[{'ade': 'Pancreatitis', 'drug': 'L-asparaginase'}]",
"role": "assistant"
}
] |
Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.
|
[
{
"ade": "Neutrophilic dermatoses",
"drug": "granulocyte colony-stimulating factor"
},
{
"ade": "Neutrophilic dermatoses",
"drug": "G-CSF"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Neutrophilic dermatoses', 'drug': 'granulocyte colony-stimulating factor'}, {'ade': 'Neutrophilic dermatoses', 'drug': 'G-CSF'}]",
"role": "assistant"
}
] |
The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.
|
[
{
"ade": "agranulocytosis",
"drug": "clozapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.",
"role": "user"
},
{
"content": "[{'ade': 'agranulocytosis', 'drug': 'clozapine'}]",
"role": "assistant"
}
] |
Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.
|
[
{
"ade": "Interstitial lung disease",
"drug": "gefitinib"
},
{
"ade": "ILD",
"drug": "gefitinib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.",
"role": "user"
},
{
"content": "[{'ade': 'Interstitial lung disease', 'drug': 'gefitinib'}, {'ade': 'ILD', 'drug': 'gefitinib'}]",
"role": "assistant"
}
] |
The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.
|
[
{
"ade": "coma",
"drug": "5-FU"
},
{
"ade": "encephalopathy",
"drug": "5-FU"
},
{
"ade": "neurologic symptoms",
"drug": "5-FU"
},
{
"ade": "severe acute 5-FU reactions",
"drug": "5-FU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.",
"role": "user"
},
{
"content": "[{'ade': 'coma', 'drug': '5-FU'}, {'ade': 'encephalopathy', 'drug': '5-FU'}, {'ade': 'neurologic symptoms', 'drug': '5-FU'}, {'ade': 'severe acute 5-FU reactions', 'drug': '5-FU'}]",
"role": "assistant"
}
] |
However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.
|
[
{
"ade": "neuropathy",
"drug": "linezolid"
},
{
"ade": "peripheral neuropathy",
"drug": "linezolid"
},
{
"ade": "bone marrow depression",
"drug": "linezolid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.",
"role": "user"
},
{
"content": "[{'ade': 'neuropathy', 'drug': 'linezolid'}, {'ade': 'peripheral neuropathy', 'drug': 'linezolid'}, {'ade': 'bone marrow depression', 'drug': 'linezolid'}]",
"role": "assistant"
}
] |
A case of acute respiratory failure due to diaphragmatic weakness following adalimumab therapy for psoriasis is described.
|
[
{
"ade": "acute respiratory failure",
"drug": "adalimumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of acute respiratory failure due to diaphragmatic weakness following adalimumab therapy for psoriasis is described.",
"role": "user"
},
{
"content": "[{'ade': 'acute respiratory failure', 'drug': 'adalimumab'}]",
"role": "assistant"
}
] |
The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.
|
[
{
"ade": "occipital infarcts",
"drug": "PPA"
},
{
"ade": "extremely elevated levels of PPA",
"drug": "PPA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.",
"role": "user"
},
{
"content": "[{'ade': 'occipital infarcts', 'drug': 'PPA'}, {'ade': 'extremely elevated levels of PPA', 'drug': 'PPA'}]",
"role": "assistant"
}
] |
There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.
|
[
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'heparin'}]",
"role": "assistant"
}
] |
He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.
|
[
{
"ade": "fever",
"drug": "chlorambucil"
},
{
"ade": "hypereosinophilia",
"drug": "chlorambucil"
},
{
"ade": "acute renal failure",
"drug": "chlorambucil"
},
{
"ade": "skin rash",
"drug": "chlorambucil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.",
"role": "user"
},
{
"content": "[{'ade': 'fever', 'drug': 'chlorambucil'}, {'ade': 'hypereosinophilia', 'drug': 'chlorambucil'}, {'ade': 'acute renal failure', 'drug': 'chlorambucil'}, {'ade': 'skin rash', 'drug': 'chlorambucil'}]",
"role": "assistant"
}
] |
Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy.
|
[
{
"ade": "thyrotoxicosis",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy.",
"role": "user"
},
{
"content": "[{'ade': 'thyrotoxicosis', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome.
|
[
{
"ade": "respiratory depression",
"drug": "morphine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'respiratory depression', 'drug': 'morphine'}]",
"role": "assistant"
}
] |
The occurrence of BMTN in two children treated with RA in our unit is unlikely to be coincidental.
|
[
{
"ade": "BMTN",
"drug": "RA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The occurrence of BMTN in two children treated with RA in our unit is unlikely to be coincidental.",
"role": "user"
},
{
"content": "[{'ade': 'BMTN', 'drug': 'RA'}]",
"role": "assistant"
}
] |
Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.
|
[
{
"ade": "interstitial lung disease",
"drug": "sorafenib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.",
"role": "user"
},
{
"content": "[{'ade': 'interstitial lung disease', 'drug': 'sorafenib'}]",
"role": "assistant"
}
] |
Dipyrone-induced granulocytopenia: a case for awareness.
|
[
{
"ade": "granulocytopenia",
"drug": "Dipyrone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Dipyrone-induced granulocytopenia: a case for awareness.",
"role": "user"
},
{
"content": "[{'ade': 'granulocytopenia', 'drug': 'Dipyrone'}]",
"role": "assistant"
}
] |
We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug.
|
[
{
"ade": "increased cerebral cortical excitability",
"drug": "flupirtine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug.",
"role": "user"
},
{
"content": "[{'ade': 'increased cerebral cortical excitability', 'drug': 'flupirtine'}]",
"role": "assistant"
}
] |
Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.
|
[
{
"ade": "minor dizziness",
"drug": "ciprofloxacin"
},
{
"ade": "mild headache",
"drug": "ciprofloxacin"
},
{
"ade": "seizures",
"drug": "ciprofloxacin"
},
{
"ade": "hallucinations",
"drug": "ciprofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.",
"role": "user"
},
{
"content": "[{'ade': 'minor dizziness', 'drug': 'ciprofloxacin'}, {'ade': 'mild headache', 'drug': 'ciprofloxacin'}, {'ade': 'seizures', 'drug': 'ciprofloxacin'}, {'ade': 'hallucinations', 'drug': 'ciprofloxacin'}]",
"role": "assistant"
}
] |
Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.
|
[
{
"ade": "Hyponatremia",
"drug": "lorcainide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.",
"role": "user"
},
{
"content": "[{'ade': 'Hyponatremia', 'drug': 'lorcainide'}]",
"role": "assistant"
}
] |
Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol.
|
[
{
"ade": "bronchospasm",
"drug": "propranolol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol.",
"role": "user"
},
{
"content": "[{'ade': 'bronchospasm', 'drug': 'propranolol'}]",
"role": "assistant"
}
] |
Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.
|
[
{
"ade": "non-convulsive status epilepticus",
"drug": "tiagabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.",
"role": "user"
},
{
"content": "[{'ade': 'non-convulsive status epilepticus', 'drug': 'tiagabine'}]",
"role": "assistant"
}
] |
Stupor and fast activity on electroencephalography in a child treated with valproate.
|
[
{
"ade": "Stupor",
"drug": "valproate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Stupor and fast activity on electroencephalography in a child treated with valproate.",
"role": "user"
},
{
"content": "[{'ade': 'Stupor', 'drug': 'valproate'}]",
"role": "assistant"
}
] |
We conclude peripheral neuropathy with 5-FU is rare.
|
[
{
"ade": "peripheral neuropathy",
"drug": "5-FU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We conclude peripheral neuropathy with 5-FU is rare.",
"role": "user"
},
{
"content": "[{'ade': 'peripheral neuropathy', 'drug': '5-FU'}]",
"role": "assistant"
}
] |
OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.
|
[
{
"ade": "serotonin syndrome",
"drug": "venlafaxine"
},
{
"ade": "extrapyramidal movement disorders",
"drug": "venlafaxine"
},
{
"ade": "extrapyramidal movement disorders",
"drug": "sertraline"
},
{
"ade": "serotonin syndrome",
"drug": "metoclopramide"
},
{
"ade": "extrapyramidal movement disorders",
"drug": "metoclopramide"
},
{
"ade": "serotonin syndrome",
"drug": "sertraline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.",
"role": "user"
},
{
"content": "[{'ade': 'serotonin syndrome', 'drug': 'venlafaxine'}, {'ade': 'extrapyramidal movement disorders', 'drug': 'venlafaxine'}, {'ade': 'extrapyramidal movement disorders', 'drug': 'sertraline'}, {'ade': 'serotonin syndrome', 'drug': 'metoclopramide'}, {'ade': 'extrapyramidal movement disorders', 'drug': 'metoclopramide'}, {'ade': 'serotonin syndrome', 'drug': 'sertraline'}]",
"role": "assistant"
}
] |
Pericardial hemorrhage due to acetylsalicylic acid in a patient with essential thrombocythemia.
|
[
{
"ade": "Pericardial hemorrhage",
"drug": "acetylsalicylic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Pericardial hemorrhage due to acetylsalicylic acid in a patient with essential thrombocythemia.",
"role": "user"
},
{
"content": "[{'ade': 'Pericardial hemorrhage', 'drug': 'acetylsalicylic acid'}]",
"role": "assistant"
}
] |
During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.
|
[
{
"ade": "IDDM",
"drug": "IFN"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.",
"role": "user"
},
{
"content": "[{'ade': 'IDDM', 'drug': 'IFN'}]",
"role": "assistant"
}
] |
This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.
|
[
{
"ade": "ulcerating enteritis",
"drug": "flucytosine"
},
{
"ade": "severe luminal narrowing",
"drug": "flucytosine"
},
{
"ade": "marked separation of loops of bowel",
"drug": "flucytosine"
},
{
"ade": "ulceration",
"drug": "flucytosine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.",
"role": "user"
},
{
"content": "[{'ade': 'ulcerating enteritis', 'drug': 'flucytosine'}, {'ade': 'severe luminal narrowing', 'drug': 'flucytosine'}, {'ade': 'marked separation of loops of bowel', 'drug': 'flucytosine'}, {'ade': 'ulceration', 'drug': 'flucytosine'}]",
"role": "assistant"
}
] |
A case of mania associated with fluoxetine.
|
[
{
"ade": "mania",
"drug": "fluoxetine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of mania associated with fluoxetine.",
"role": "user"
},
{
"content": "[{'ade': 'mania', 'drug': 'fluoxetine'}]",
"role": "assistant"
}
] |
Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.
|
[
{
"ade": "CNS lymphoma",
"drug": "mycophenolate mofetil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.",
"role": "user"
},
{
"content": "[{'ade': 'CNS lymphoma', 'drug': 'mycophenolate mofetil'}]",
"role": "assistant"
}
] |
Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist.
|
[
{
"ade": "Severe hyperkalemia",
"drug": "timolol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist.",
"role": "user"
},
{
"content": "[{'ade': 'Severe hyperkalemia', 'drug': 'timolol'}]",
"role": "assistant"
}
] |
Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.
|
[
{
"ade": "thyrotoxicosis",
"drug": "amiodarone"
},
{
"ade": "hypothyroidism",
"drug": "amiodarone"
},
{
"ade": "Goiter",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.",
"role": "user"
},
{
"content": "[{'ade': 'thyrotoxicosis', 'drug': 'amiodarone'}, {'ade': 'hypothyroidism', 'drug': 'amiodarone'}, {'ade': 'Goiter', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure.
|
[
{
"ade": "respiratory failure",
"drug": "vecuronium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure.",
"role": "user"
},
{
"content": "[{'ade': 'respiratory failure', 'drug': 'vecuronium'}]",
"role": "assistant"
}
] |
The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.
|
[
{
"ade": "pericardial hemorrhage",
"drug": "acetylsalicylic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.",
"role": "user"
},
{
"content": "[{'ade': 'pericardial hemorrhage', 'drug': 'acetylsalicylic acid'}]",
"role": "assistant"
}
] |
Hepatotoxic effects in a child receiving valproate and carnitine.
|
[
{
"ade": "Hepatotoxic effects",
"drug": "valproate"
},
{
"ade": "Hepatotoxic effects",
"drug": "carnitine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatotoxic effects in a child receiving valproate and carnitine.",
"role": "user"
},
{
"content": "[{'ade': 'Hepatotoxic effects', 'drug': 'valproate'}, {'ade': 'Hepatotoxic effects', 'drug': 'carnitine'}]",
"role": "assistant"
}
] |
Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease.
|
[
{
"ade": "disseminated histoplasmosis",
"drug": "prednisone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease.",
"role": "user"
},
{
"content": "[{'ade': 'disseminated histoplasmosis', 'drug': 'prednisone'}]",
"role": "assistant"
}
] |
Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.
|
[
{
"ade": "colitis",
"drug": "cisplatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.",
"role": "user"
},
{
"content": "[{'ade': 'colitis', 'drug': 'cisplatin'}]",
"role": "assistant"
}
] |
A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy.
|
[
{
"ade": "abnormal posture of extreme forward flexion",
"drug": "valproate"
},
{
"ade": "camptocormia",
"drug": "valproate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy.",
"role": "user"
},
{
"content": "[{'ade': 'abnormal posture of extreme forward flexion', 'drug': 'valproate'}, {'ade': 'camptocormia', 'drug': 'valproate'}]",
"role": "assistant"
}
] |
The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.
|
[
{
"ade": "pain to the teeth",
"drug": "niacin"
},
{
"ade": "prostaglandin-mediated vasodilatation",
"drug": "niacin"
},
{
"ade": "hyperalgesia of sensory nerve receptors",
"drug": "niacin"
},
{
"ade": "potentiation of inflammation in the gingiva",
"drug": "niacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.",
"role": "user"
},
{
"content": "[{'ade': 'pain to the teeth', 'drug': 'niacin'}, {'ade': 'prostaglandin-mediated vasodilatation', 'drug': 'niacin'}, {'ade': 'hyperalgesia of sensory nerve receptors', 'drug': 'niacin'}, {'ade': 'potentiation of inflammation in the gingiva', 'drug': 'niacin'}]",
"role": "assistant"
}
] |
RESULTS: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity.
|
[
{
"ade": "platinum hypersensitivity",
"drug": "carboplatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity.",
"role": "user"
},
{
"content": "[{'ade': 'platinum hypersensitivity', 'drug': 'carboplatin'}]",
"role": "assistant"
}
] |
We suggest discontinuing gemcitabine if radiation recall is observed.
|
[
{
"ade": "radiation recall",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We suggest discontinuing gemcitabine if radiation recall is observed.",
"role": "user"
},
{
"content": "[{'ade': 'radiation recall', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.
|
[
{
"ade": "died",
"drug": "doxorubicin"
},
{
"ade": "Adriamycin toxicity",
"drug": "doxorubicin"
},
{
"ade": "Adriamycin toxicity",
"drug": "Adriamycin"
},
{
"ade": "died",
"drug": "Adriamycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.",
"role": "user"
},
{
"content": "[{'ade': 'died', 'drug': 'doxorubicin'}, {'ade': 'Adriamycin toxicity', 'drug': 'doxorubicin'}, {'ade': 'Adriamycin toxicity', 'drug': 'Adriamycin'}, {'ade': 'died', 'drug': 'Adriamycin'}]",
"role": "assistant"
}
] |
Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.
|
[
{
"ade": "hepatocellular injury",
"drug": "isradipine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.",
"role": "user"
},
{
"content": "[{'ade': 'hepatocellular injury', 'drug': 'isradipine'}]",
"role": "assistant"
}
] |
Penicillin-induced Jarisch-Herxheimer reaction.
|
[
{
"ade": "Jarisch-Herxheimer reaction",
"drug": "Penicillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Penicillin-induced Jarisch-Herxheimer reaction.",
"role": "user"
},
{
"content": "[{'ade': 'Jarisch-Herxheimer reaction', 'drug': 'Penicillin'}]",
"role": "assistant"
}
] |
Two patients on long-term lithium therapy developed the nephrotic syndrome.
|
[
{
"ade": "nephrotic syndrome",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two patients on long-term lithium therapy developed the nephrotic syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'nephrotic syndrome', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.
|
[
{
"ade": "teratogenicity",
"drug": "lithium"
},
{
"ade": "Epstein's anomaly",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.",
"role": "user"
},
{
"content": "[{'ade': 'teratogenicity', 'drug': 'lithium'}, {'ade': \"Epstein's anomaly\", 'drug': 'lithium'}]",
"role": "assistant"
}
] |
Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.
|
[
{
"ade": "Proconvulsive",
"drug": "imipenem"
},
{
"ade": "Proconvulsive",
"drug": "cilastatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.",
"role": "user"
},
{
"content": "[{'ade': 'Proconvulsive', 'drug': 'imipenem'}, {'ade': 'Proconvulsive', 'drug': 'cilastatin'}]",
"role": "assistant"
}
] |
Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.
|
[
{
"ade": "ifosfamide-induced encephalopathy",
"drug": "ifosfamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.",
"role": "user"
},
{
"content": "[{'ade': 'ifosfamide-induced encephalopathy', 'drug': 'ifosfamide'}]",
"role": "assistant"
}
] |
We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).
|
[
{
"ade": "acute encephalopathy",
"drug": "HOPA"
},
{
"ade": "acute encephalopathy",
"drug": "calcium hopantenate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).",
"role": "user"
},
{
"content": "[{'ade': 'acute encephalopathy', 'drug': 'HOPA'}, {'ade': 'acute encephalopathy', 'drug': 'calcium hopantenate'}]",
"role": "assistant"
}
] |
This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.
|
[
{
"ade": "ductopenia",
"drug": "clindamycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.",
"role": "user"
},
{
"content": "[{'ade': 'ductopenia', 'drug': 'clindamycin'}]",
"role": "assistant"
}
] |
We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.
|
[
{
"ade": "psychotic disorder",
"drug": "isoniazid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.",
"role": "user"
},
{
"content": "[{'ade': 'psychotic disorder', 'drug': 'isoniazid'}]",
"role": "assistant"
}
] |
In this report, two newborns with congenital heart anomalies demonstrated the harlequin color change, one whose skin findings showed a course related to the dose of systemic prostaglandin E1, suggesting a possible association.
|
[
{
"ade": "harlequin color change",
"drug": "prostaglandin E1"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In this report, two newborns with congenital heart anomalies demonstrated the harlequin color change, one whose skin findings showed a course related to the dose of systemic prostaglandin E1, suggesting a possible association.",
"role": "user"
},
{
"content": "[{'ade': 'harlequin color change', 'drug': 'prostaglandin E1'}]",
"role": "assistant"
}
] |
A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.
|
[
{
"ade": "EEG abnormalities",
"drug": "amphotericin B"
},
{
"ade": "acute toxic delirium",
"drug": "amphotericin B"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.",
"role": "user"
},
{
"content": "[{'ade': 'EEG abnormalities', 'drug': 'amphotericin B'}, {'ade': 'acute toxic delirium', 'drug': 'amphotericin B'}]",
"role": "assistant"
}
] |
Severe neurotoxicity with methyl G: CALGB experience.
|
[
{
"ade": "Severe neurotoxicity",
"drug": "methyl G: CALGB"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe neurotoxicity with methyl G: CALGB experience.",
"role": "user"
},
{
"content": "[{'ade': 'Severe neurotoxicity', 'drug': 'methyl G: CALGB'}]",
"role": "assistant"
}
] |
Falling backward in two elderly patients taking bupropion.
|
[
{
"ade": "Falling backward",
"drug": "bupropion"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Falling backward in two elderly patients taking bupropion.",
"role": "user"
},
{
"content": "[{'ade': 'Falling backward', 'drug': 'bupropion'}]",
"role": "assistant"
}
] |
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