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One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.
|
[
{
"ade": "neurotoxicity",
"drug": "cyclosporin"
},
{
"ade": "MRI T2 abnormalities",
"drug": "cyclosporin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.",
"role": "user"
},
{
"content": "[{'ade': 'neurotoxicity', 'drug': 'cyclosporin'}, {'ade': 'MRI T2 abnormalities', 'drug': 'cyclosporin'}]",
"role": "assistant"
}
] |
Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.
|
[
{
"ade": "Lupus-like syndrome",
"drug": "5-aminosalicylic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.",
"role": "user"
},
{
"content": "[{'ade': 'Lupus-like syndrome', 'drug': '5-aminosalicylic acid'}]",
"role": "assistant"
}
] |
Optic neuropathy associated with penicillamine therapy in a patient with rheumatoid arthritis.
|
[
{
"ade": "Optic neuropathy",
"drug": "penicillamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Optic neuropathy associated with penicillamine therapy in a patient with rheumatoid arthritis.",
"role": "user"
},
{
"content": "[{'ade': 'Optic neuropathy', 'drug': 'penicillamine'}]",
"role": "assistant"
}
] |
The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.
|
[
{
"ade": "interstitial nephritis",
"drug": "indinavir"
},
{
"ade": "nephrolithiasis",
"drug": "indinavir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.",
"role": "user"
},
{
"content": "[{'ade': 'interstitial nephritis', 'drug': 'indinavir'}, {'ade': 'nephrolithiasis', 'drug': 'indinavir'}]",
"role": "assistant"
}
] |
In a postoperative patient with pre-existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.
|
[
{
"ade": "exacerbation in myasthenic weakness",
"drug": "verapamil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In a postoperative patient with pre-existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.",
"role": "user"
},
{
"content": "[{'ade': 'exacerbation in myasthenic weakness', 'drug': 'verapamil'}]",
"role": "assistant"
}
] |
This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue.
|
[
{
"ade": "hypersensitivity",
"drug": "carboplatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity', 'drug': 'carboplatin'}]",
"role": "assistant"
}
] |
We report a case of myoclonus induced by quetiapine.
|
[
{
"ade": "myoclonus",
"drug": "quetiapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of myoclonus induced by quetiapine.",
"role": "user"
},
{
"content": "[{'ade': 'myoclonus', 'drug': 'quetiapine'}]",
"role": "assistant"
}
] |
In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.
|
[
{
"ade": "dyskinesias",
"drug": "apomorphine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.",
"role": "user"
},
{
"content": "[{'ade': 'dyskinesias', 'drug': 'apomorphine'}]",
"role": "assistant"
}
] |
Metformin-associated lactic acidosis precipitated by diarrhea.
|
[
{
"ade": "lactic acidosis",
"drug": "Metformin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Metformin-associated lactic acidosis precipitated by diarrhea.",
"role": "user"
},
{
"content": "[{'ade': 'lactic acidosis', 'drug': 'Metformin'}]",
"role": "assistant"
}
] |
We report in detail an unusual adverse reaction to infliximab therapy, a drug-induced lupus-like clinical syndrome.
|
[
{
"ade": "lupus-like clinical syndrome",
"drug": "infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report in detail an unusual adverse reaction to infliximab therapy, a drug-induced lupus-like clinical syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'lupus-like clinical syndrome', 'drug': 'infliximab'}]",
"role": "assistant"
}
] |
During analysis of 28 patients receiving CAP with concomitant radiation (XRT) for pancreatic cancer (resected or locally advanced), two patients developed signs and symptoms consistent with peripheral neuropathy.
|
[
{
"ade": "peripheral neuropathy",
"drug": "CAP"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: During analysis of 28 patients receiving CAP with concomitant radiation (XRT) for pancreatic cancer (resected or locally advanced), two patients developed signs and symptoms consistent with peripheral neuropathy.",
"role": "user"
},
{
"content": "[{'ade': 'peripheral neuropathy', 'drug': 'CAP'}]",
"role": "assistant"
}
] |
This case had radiation fibrosis, so we suggest that radiation fibrosis may be another contributor of the occurrence of ILD in patients taking erlotinib.
|
[
{
"ade": "ILD",
"drug": "erlotinib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case had radiation fibrosis, so we suggest that radiation fibrosis may be another contributor of the occurrence of ILD in patients taking erlotinib.",
"role": "user"
},
{
"content": "[{'ade': 'ILD', 'drug': 'erlotinib'}]",
"role": "assistant"
}
] |
Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.
|
[
{
"ade": "Rhabdomyolysis",
"drug": "ritodrine hydrochloride"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.",
"role": "user"
},
{
"content": "[{'ade': 'Rhabdomyolysis', 'drug': 'ritodrine hydrochloride'}]",
"role": "assistant"
}
] |
This case illustrates the potential decoupling of PSA response from disease status in flutamide withdrawal.
|
[
{
"ade": "decoupling of PSA response",
"drug": "flutamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case illustrates the potential decoupling of PSA response from disease status in flutamide withdrawal.",
"role": "user"
},
{
"content": "[{'ade': 'decoupling of PSA response', 'drug': 'flutamide'}]",
"role": "assistant"
}
] |
Near fatal acute colchicine intoxication in a child.
|
[
{
"ade": "Near fatal",
"drug": "colchicine"
},
{
"ade": "colchicine intoxication",
"drug": "colchicine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Near fatal acute colchicine intoxication in a child.",
"role": "user"
},
{
"content": "[{'ade': 'Near fatal', 'drug': 'colchicine'}, {'ade': 'colchicine intoxication', 'drug': 'colchicine'}]",
"role": "assistant"
}
] |
The possible role of interferon beta in the pathogenesis of sarcoidosis in this patient is discussed.
|
[
{
"ade": "sarcoidosis",
"drug": "interferon beta"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The possible role of interferon beta in the pathogenesis of sarcoidosis in this patient is discussed.",
"role": "user"
},
{
"content": "[{'ade': 'sarcoidosis', 'drug': 'interferon beta'}]",
"role": "assistant"
}
] |
To date, there have been few reports of visual disturbances associated with BTX-B use.
|
[
{
"ade": "visual disturbances",
"drug": "BTX-B"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To date, there have been few reports of visual disturbances associated with BTX-B use.",
"role": "user"
},
{
"content": "[{'ade': 'visual disturbances', 'drug': 'BTX-B'}]",
"role": "assistant"
}
] |
Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.
|
[
{
"ade": "general erythema",
"drug": "cisplatin"
},
{
"ade": "abdominal pain",
"drug": "cisplatin"
},
{
"ade": "dyspnea",
"drug": "cisplatin"
},
{
"ade": "fever",
"drug": "cisplatin"
},
{
"ade": "hypotension",
"drug": "cisplatin"
},
{
"ade": "hypersensitivity reactions",
"drug": "cisplatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",
"role": "user"
},
{
"content": "[{'ade': 'general erythema', 'drug': 'cisplatin'}, {'ade': 'abdominal pain', 'drug': 'cisplatin'}, {'ade': 'dyspnea', 'drug': 'cisplatin'}, {'ade': 'fever', 'drug': 'cisplatin'}, {'ade': 'hypotension', 'drug': 'cisplatin'}, {'ade': 'hypersensitivity reactions', 'drug': 'cisplatin'}]",
"role": "assistant"
}
] |
He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.
|
[
{
"ade": "fever",
"drug": "Pentasa"
},
{
"ade": "nausea",
"drug": "Pentasa"
},
{
"ade": "diarrhea",
"drug": "Pentasa"
},
{
"ade": "malaise",
"drug": "Pentasa"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.",
"role": "user"
},
{
"content": "[{'ade': 'fever', 'drug': 'Pentasa'}, {'ade': 'nausea', 'drug': 'Pentasa'}, {'ade': 'diarrhea', 'drug': 'Pentasa'}, {'ade': 'malaise', 'drug': 'Pentasa'}]",
"role": "assistant"
}
] |
We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.
|
[
{
"ade": "hepatic adenomas",
"drug": "danazol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.",
"role": "user"
},
{
"content": "[{'ade': 'hepatic adenomas', 'drug': 'danazol'}]",
"role": "assistant"
}
] |
We report a case of baclofen withdrawal syndrome resulting from oral baclofen underdosing.
|
[
{
"ade": "withdrawal syndrome",
"drug": "baclofen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of baclofen withdrawal syndrome resulting from oral baclofen underdosing.",
"role": "user"
},
{
"content": "[{'ade': 'withdrawal syndrome', 'drug': 'baclofen'}]",
"role": "assistant"
}
] |
We present a case in which dipyridamole induced high-grade atrioventricular (AV) block that responded promptly to intravenous aminophylline but not to atropine.
|
[
{
"ade": "high-grade atrioventricular (AV) block",
"drug": "dipyridamole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present a case in which dipyridamole induced high-grade atrioventricular (AV) block that responded promptly to intravenous aminophylline but not to atropine.",
"role": "user"
},
{
"content": "[{'ade': 'high-grade atrioventricular (AV) block', 'drug': 'dipyridamole'}]",
"role": "assistant"
}
] |
Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.
|
[
{
"ade": "infectious complications",
"drug": "ARA-C"
},
{
"ade": "gastrointestinal tract symptoms",
"drug": "ARA-C"
},
{
"ade": "severe myalgias",
"drug": "cytosine arabinoside"
},
{
"ade": "fever",
"drug": "ARA-C"
},
{
"ade": "severe myalgias",
"drug": "ARA-C"
},
{
"ade": "infectious complications",
"drug": "cytosine arabinoside"
},
{
"ade": "gastrointestinal tract symptoms",
"drug": "cytosine arabinoside"
},
{
"ade": "fever",
"drug": "cytosine arabinoside"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.",
"role": "user"
},
{
"content": "[{'ade': 'infectious complications', 'drug': 'ARA-C'}, {'ade': 'gastrointestinal tract symptoms', 'drug': 'ARA-C'}, {'ade': 'severe myalgias', 'drug': 'cytosine arabinoside'}, {'ade': 'fever', 'drug': 'ARA-C'}, {'ade': 'severe myalgias', 'drug': 'ARA-C'}, {'ade': 'infectious complications', 'drug': 'cytosine arabinoside'}, {'ade': 'gastrointestinal tract symptoms', 'drug': 'cytosine arabinoside'}, {'ade': 'fever', 'drug': 'cytosine arabinoside'}]",
"role": "assistant"
}
] |
A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.
|
[
{
"ade": "acute renal failure",
"drug": "acyclovir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.",
"role": "user"
},
{
"content": "[{'ade': 'acute renal failure', 'drug': 'acyclovir'}]",
"role": "assistant"
}
] |
Clinicians should be aware that an erythematous and exfoliative rash may be induced by temozolomide, and be familiar with the pharmacologic and supportive measures necessary for its treatment.
|
[
{
"ade": "exfoliative rash",
"drug": "temozolomide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Clinicians should be aware that an erythematous and exfoliative rash may be induced by temozolomide, and be familiar with the pharmacologic and supportive measures necessary for its treatment.",
"role": "user"
},
{
"content": "[{'ade': 'exfoliative rash', 'drug': 'temozolomide'}]",
"role": "assistant"
}
] |
Clostridium difficile toxin-induced colitis after use of clindamycin phosphate vaginal cream.
|
[
{
"ade": "Clostridium difficile toxin-induced colitis",
"drug": "clindamycin phosphate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Clostridium difficile toxin-induced colitis after use of clindamycin phosphate vaginal cream.",
"role": "user"
},
{
"content": "[{'ade': 'Clostridium difficile toxin-induced colitis', 'drug': 'clindamycin phosphate'}]",
"role": "assistant"
}
] |
Vision declined after treatment with methylprednisolone, after which fundus examination became consistent with progressive outer retinal necrosis.
|
[
{
"ade": "Vision declined",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Vision declined after treatment with methylprednisolone, after which fundus examination became consistent with progressive outer retinal necrosis.",
"role": "user"
},
{
"content": "[{'ade': 'Vision declined', 'drug': 'methylprednisolone'}]",
"role": "assistant"
}
] |
We describe a patient with idiopathic RLS who developed augmentation after 8 months of levodopa treatment.
|
[
{
"ade": "augmentation",
"drug": "levodopa"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a patient with idiopathic RLS who developed augmentation after 8 months of levodopa treatment.",
"role": "user"
},
{
"content": "[{'ade': 'augmentation', 'drug': 'levodopa'}]",
"role": "assistant"
}
] |
Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy.
|
[
{
"ade": "agranulocytosis",
"drug": "infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy.",
"role": "user"
},
{
"content": "[{'ade': 'agranulocytosis', 'drug': 'infliximab'}]",
"role": "assistant"
}
] |
Case report: lack of control of diabetes and weight gain in a patient on initiation and rechallenge of therapy with olanzapine.
|
[
{
"ade": "weight gain",
"drug": "olanzapine"
},
{
"ade": "diabetes",
"drug": "olanzapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Case report: lack of control of diabetes and weight gain in a patient on initiation and rechallenge of therapy with olanzapine.",
"role": "user"
},
{
"content": "[{'ade': 'weight gain', 'drug': 'olanzapine'}, {'ade': 'diabetes', 'drug': 'olanzapine'}]",
"role": "assistant"
}
] |
Vocal cord paralysis as a consequence of peritonsillar infiltration with bupivacaine.
|
[
{
"ade": "Vocal cord paralysis",
"drug": "bupivacaine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Vocal cord paralysis as a consequence of peritonsillar infiltration with bupivacaine.",
"role": "user"
},
{
"content": "[{'ade': 'Vocal cord paralysis', 'drug': 'bupivacaine'}]",
"role": "assistant"
}
] |
Myoclonic spasms following intrathecal morphine.
|
[
{
"ade": "Myoclonic spasms",
"drug": "morphine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Myoclonic spasms following intrathecal morphine.",
"role": "user"
},
{
"content": "[{'ade': 'Myoclonic spasms', 'drug': 'morphine'}]",
"role": "assistant"
}
] |
We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G-CSF therapy.
|
[
{
"ade": "skin eruptions",
"drug": "G-CSF"
},
{
"ade": "neutrophilic dermatoses",
"drug": "G-CSF"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G-CSF therapy.",
"role": "user"
},
{
"content": "[{'ade': 'skin eruptions', 'drug': 'G-CSF'}, {'ade': 'neutrophilic dermatoses', 'drug': 'G-CSF'}]",
"role": "assistant"
}
] |
Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.
|
[
{
"ade": "acute vision loss",
"drug": "bevacizumab"
},
{
"ade": "change of consciousness",
"drug": "bevacizumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.",
"role": "user"
},
{
"content": "[{'ade': 'acute vision loss', 'drug': 'bevacizumab'}, {'ade': 'change of consciousness', 'drug': 'bevacizumab'}]",
"role": "assistant"
}
] |
Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C.
|
[
{
"ade": "Vogt-Koyanagi-Harada disease",
"drug": "interferon alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C.",
"role": "user"
},
{
"content": "[{'ade': 'Vogt-Koyanagi-Harada disease', 'drug': 'interferon alpha'}]",
"role": "assistant"
}
] |
Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases.
|
[
{
"ade": "severe hypocalcaemia",
"drug": "Zoledronic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases.",
"role": "user"
},
{
"content": "[{'ade': 'severe hypocalcaemia', 'drug': 'Zoledronic acid'}]",
"role": "assistant"
}
] |
Polymyositis after propylthiouracil treatment for hyperthyroidism.
|
[
{
"ade": "Polymyositis",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Polymyositis after propylthiouracil treatment for hyperthyroidism.",
"role": "user"
},
{
"content": "[{'ade': 'Polymyositis', 'drug': 'propylthiouracil'}]",
"role": "assistant"
}
] |
Patients treated with captopril who develop "atypical cholangitis" should be suspected of having captopril-associated liver damage.
|
[
{
"ade": "atypical cholangitis",
"drug": "captopril"
},
{
"ade": "liver damage",
"drug": "captopril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Patients treated with captopril who develop \"atypical cholangitis\" should be suspected of having captopril-associated liver damage.",
"role": "user"
},
{
"content": "[{'ade': 'atypical cholangitis', 'drug': 'captopril'}, {'ade': 'liver damage', 'drug': 'captopril'}]",
"role": "assistant"
}
] |
We present the case of a patient who had undergone cholecystectomy previously, but in whom morphine given in the Emergency Department precipitated pain consistent with biliary colic; the pain resolved promptly after administration of naloxone.
|
[
{
"ade": "pain",
"drug": "morphine"
},
{
"ade": "biliary colic",
"drug": "morphine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present the case of a patient who had undergone cholecystectomy previously, but in whom morphine given in the Emergency Department precipitated pain consistent with biliary colic; the pain resolved promptly after administration of naloxone.",
"role": "user"
},
{
"content": "[{'ade': 'pain', 'drug': 'morphine'}, {'ade': 'biliary colic', 'drug': 'morphine'}]",
"role": "assistant"
}
] |
In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.
|
[
{
"ade": "alters bile acid composition",
"drug": "octreotide"
},
{
"ade": "stone formation",
"drug": "octreotide"
},
{
"ade": "gallbladder stasis",
"drug": "octreotide"
},
{
"ade": "hasten intrahepatic sludge",
"drug": "octreotide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.",
"role": "user"
},
{
"content": "[{'ade': 'alters bile acid composition', 'drug': 'octreotide'}, {'ade': 'stone formation', 'drug': 'octreotide'}, {'ade': 'gallbladder stasis', 'drug': 'octreotide'}, {'ade': 'hasten intrahepatic sludge', 'drug': 'octreotide'}]",
"role": "assistant"
}
] |
Hair loss associated with paroxetine treatment: a case report.
|
[
{
"ade": "Hair loss",
"drug": "paroxetine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hair loss associated with paroxetine treatment: a case report.",
"role": "user"
},
{
"content": "[{'ade': 'Hair loss', 'drug': 'paroxetine'}]",
"role": "assistant"
}
] |
A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.
|
[
{
"ade": "lethargic",
"drug": "brimonidine"
},
{
"ade": "poorly responsive",
"drug": "brimonidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.",
"role": "user"
},
{
"content": "[{'ade': 'lethargic', 'drug': 'brimonidine'}, {'ade': 'poorly responsive', 'drug': 'brimonidine'}]",
"role": "assistant"
}
] |
CONCLUSION: Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole.
|
[
{
"ade": "eruption",
"drug": "omeprazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole.",
"role": "user"
},
{
"content": "[{'ade': 'eruption', 'drug': 'omeprazole'}]",
"role": "assistant"
}
] |
This is a case report of possible association of methylphenidate and enuresis in an 11-year-old boy with attention deficit hyperactivity disorder.
|
[
{
"ade": "enuresis",
"drug": "methylphenidate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is a case report of possible association of methylphenidate and enuresis in an 11-year-old boy with attention deficit hyperactivity disorder.",
"role": "user"
},
{
"content": "[{'ade': 'enuresis', 'drug': 'methylphenidate'}]",
"role": "assistant"
}
] |
Progressive hypoxemia mandated endotracheal intubation 1 week after rituximab administration and led to death 4 weeks after admission.
|
[
{
"ade": "Progressive hypoxemia",
"drug": "rituximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Progressive hypoxemia mandated endotracheal intubation 1 week after rituximab administration and led to death 4 weeks after admission.",
"role": "user"
},
{
"content": "[{'ade': 'Progressive hypoxemia', 'drug': 'rituximab'}]",
"role": "assistant"
}
] |
Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.
|
[
{
"ade": "thrombocytopenia",
"drug": "Rifampin"
},
{
"ade": "hemolytic anemia",
"drug": "Rifampin"
},
{
"ade": "acute renal failure",
"drug": "Rifampin"
},
{
"ade": "hepatitis",
"drug": "Rifampin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'Rifampin'}, {'ade': 'hemolytic anemia', 'drug': 'Rifampin'}, {'ade': 'acute renal failure', 'drug': 'Rifampin'}, {'ade': 'hepatitis', 'drug': 'Rifampin'}]",
"role": "assistant"
}
] |
CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.
|
[
{
"ade": "hypercalcemia",
"drug": "vitamin D"
},
{
"ade": "acute vitamin D poisoning",
"drug": "vitamin D"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.",
"role": "user"
},
{
"content": "[{'ade': 'hypercalcemia', 'drug': 'vitamin D'}, {'ade': 'acute vitamin D poisoning', 'drug': 'vitamin D'}]",
"role": "assistant"
}
] |
OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.
|
[
{
"ade": "NMS",
"drug": "fluphenazine"
},
{
"ade": "neuroleptic malignant syndrome",
"drug": "fluphenazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.",
"role": "user"
},
{
"content": "[{'ade': 'NMS', 'drug': 'fluphenazine'}, {'ade': 'neuroleptic malignant syndrome', 'drug': 'fluphenazine'}]",
"role": "assistant"
}
] |
In addition, the tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods after procainamide.
|
[
{
"ade": "tachycardia",
"drug": "procainamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In addition, the tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods after procainamide.",
"role": "user"
},
{
"content": "[{'ade': 'tachycardia', 'drug': 'procainamide'}]",
"role": "assistant"
}
] |
Nonconvulsive status epilepticus: the role of morphine and its antagonist.
|
[
{
"ade": "Nonconvulsive status epilepticus",
"drug": "morphine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nonconvulsive status epilepticus: the role of morphine and its antagonist.",
"role": "user"
},
{
"content": "[{'ade': 'Nonconvulsive status epilepticus', 'drug': 'morphine'}]",
"role": "assistant"
}
] |
An objective causality assessment indicated a probable relationship between clotting abnormality and warfarin administration, although the degree of elevation of the INR was unusual in the light of the daily warfarin dose and duration of its exposure.
|
[
{
"ade": "clotting abnormality",
"drug": "warfarin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: An objective causality assessment indicated a probable relationship between clotting abnormality and warfarin administration, although the degree of elevation of the INR was unusual in the light of the daily warfarin dose and duration of its exposure.",
"role": "user"
},
{
"content": "[{'ade': 'clotting abnormality', 'drug': 'warfarin'}]",
"role": "assistant"
}
] |
This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy.
|
[
{
"ade": "Graves' hyperthyroidism",
"drug": "IFN"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy.",
"role": "user"
},
{
"content": "[{'ade': \"Graves' hyperthyroidism\", 'drug': 'IFN'}]",
"role": "assistant"
}
] |
Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol.
|
[
{
"ade": "hypercalcemia",
"drug": "dihydrotachysterol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol.",
"role": "user"
},
{
"content": "[{'ade': 'hypercalcemia', 'drug': 'dihydrotachysterol'}]",
"role": "assistant"
}
] |
A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.
|
[
{
"ade": "restless legs symptoms",
"drug": "IFN alpha"
},
{
"ade": "restless legs symptoms",
"drug": "interferon-alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.",
"role": "user"
},
{
"content": "[{'ade': 'restless legs symptoms', 'drug': 'IFN alpha'}, {'ade': 'restless legs symptoms', 'drug': 'interferon-alpha'}]",
"role": "assistant"
}
] |
Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.
|
[
{
"ade": "Eosinophilic cystitis",
"drug": "dimethyl sulfoxide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.",
"role": "user"
},
{
"content": "[{'ade': 'Eosinophilic cystitis', 'drug': 'dimethyl sulfoxide'}]",
"role": "assistant"
}
] |
Acute valproate ingestion induces symptomatic methemoglobinemia.
|
[
{
"ade": "symptomatic methemoglobinemia",
"drug": "valproate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute valproate ingestion induces symptomatic methemoglobinemia.",
"role": "user"
},
{
"content": "[{'ade': 'symptomatic methemoglobinemia', 'drug': 'valproate'}]",
"role": "assistant"
}
] |
Hepatic damage after danazol treatment.
|
[
{
"ade": "Hepatic damage",
"drug": "danazol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatic damage after danazol treatment.",
"role": "user"
},
{
"content": "[{'ade': 'Hepatic damage', 'drug': 'danazol'}]",
"role": "assistant"
}
] |
The second patient exhibited sudden PLMS following olanzapine injection.
|
[
{
"ade": "PLMS",
"drug": "olanzapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The second patient exhibited sudden PLMS following olanzapine injection.",
"role": "user"
},
{
"content": "[{'ade': 'PLMS', 'drug': 'olanzapine'}]",
"role": "assistant"
}
] |
In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment.
|
[
{
"ade": "aortic wall in this case was damaged",
"drug": "Bleomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment.",
"role": "user"
},
{
"content": "[{'ade': 'aortic wall in this case was damaged', 'drug': 'Bleomycin'}]",
"role": "assistant"
}
] |
The probability of developing acute leukemia in this study was not significantly correlated to the total cumulative dosage of Treosulfan.
|
[
{
"ade": "acute leukemia",
"drug": "Treosulfan"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The probability of developing acute leukemia in this study was not significantly correlated to the total cumulative dosage of Treosulfan.",
"role": "user"
},
{
"content": "[{'ade': 'acute leukemia', 'drug': 'Treosulfan'}]",
"role": "assistant"
}
] |
Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia.
|
[
{
"ade": "Tumor-volume increase",
"drug": "interferon alpha 2-beta"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia.",
"role": "user"
},
{
"content": "[{'ade': 'Tumor-volume increase', 'drug': 'interferon alpha 2-beta'}]",
"role": "assistant"
}
] |
The present report describes the first case of acute pancreatitis associated with danazol treatment of endometriosis.
|
[
{
"ade": "acute pancreatitis",
"drug": "danazol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The present report describes the first case of acute pancreatitis associated with danazol treatment of endometriosis.",
"role": "user"
},
{
"content": "[{'ade': 'acute pancreatitis', 'drug': 'danazol'}]",
"role": "assistant"
}
] |
PURPOSE: To report patients who presented to the oculoplastics department for repair of cicatrical entropion after topical use of dipivefrin.
|
[
{
"ade": "cicatrical entropion",
"drug": "dipivefrin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PURPOSE: To report patients who presented to the oculoplastics department for repair of cicatrical entropion after topical use of dipivefrin.",
"role": "user"
},
{
"content": "[{'ade': 'cicatrical entropion', 'drug': 'dipivefrin'}]",
"role": "assistant"
}
] |
Although it is difficult to solely attribute intratumoral hemorrhage to aspirin, we have to be careful when prescribing aspirin for patients who have asymptomatic meningioma.
|
[
{
"ade": "intratumoral hemorrhage",
"drug": "aspirin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although it is difficult to solely attribute intratumoral hemorrhage to aspirin, we have to be careful when prescribing aspirin for patients who have asymptomatic meningioma.",
"role": "user"
},
{
"content": "[{'ade': 'intratumoral hemorrhage', 'drug': 'aspirin'}]",
"role": "assistant"
}
] |
We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.
|
[
{
"ade": "anticonvulsant hypersensitivity syndrome",
"drug": "phenobarbital"
},
{
"ade": "anticonvulsant hypersensitivity syndrome",
"drug": "belladonna alkaloids"
},
{
"ade": "anticonvulsant hypersensitivity syndrome",
"drug": "Bellamine S"
},
{
"ade": "anticonvulsant hypersensitivity syndrome",
"drug": "ergotamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.",
"role": "user"
},
{
"content": "[{'ade': 'anticonvulsant hypersensitivity syndrome', 'drug': 'phenobarbital'}, {'ade': 'anticonvulsant hypersensitivity syndrome', 'drug': 'belladonna alkaloids'}, {'ade': 'anticonvulsant hypersensitivity syndrome', 'drug': 'Bellamine S'}, {'ade': 'anticonvulsant hypersensitivity syndrome', 'drug': 'ergotamine'}]",
"role": "assistant"
}
] |
According to the Naranjo adverse drug reaction probability scale, the likelihood that temozolomide was responsible for the adverse drug reaction of fever was probable (score of 6).
|
[
{
"ade": "fever",
"drug": "temozolomide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: According to the Naranjo adverse drug reaction probability scale, the likelihood that temozolomide was responsible for the adverse drug reaction of fever was probable (score of 6).",
"role": "user"
},
{
"content": "[{'ade': 'fever', 'drug': 'temozolomide'}]",
"role": "assistant"
}
] |
Torsade de pointes represents a potential complication of chronic amiodarone therapy.
|
[
{
"ade": "Torsade de pointes",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Torsade de pointes represents a potential complication of chronic amiodarone therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Torsade de pointes', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.
|
[
{
"ade": "retinal hemorrhages",
"drug": "Interferon"
},
{
"ade": "cotton wool spots",
"drug": "Interferon"
},
{
"ade": "cotton wool spots",
"drug": "IFN"
},
{
"ade": "retinopathy",
"drug": "Interferon"
},
{
"ade": "retinal hemorrhages",
"drug": "IFN"
},
{
"ade": "retinopathy",
"drug": "IFN"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.",
"role": "user"
},
{
"content": "[{'ade': 'retinal hemorrhages', 'drug': 'Interferon'}, {'ade': 'cotton wool spots', 'drug': 'Interferon'}, {'ade': 'cotton wool spots', 'drug': 'IFN'}, {'ade': 'retinopathy', 'drug': 'Interferon'}, {'ade': 'retinal hemorrhages', 'drug': 'IFN'}, {'ade': 'retinopathy', 'drug': 'IFN'}]",
"role": "assistant"
}
] |
Initiation of posaconazole led to clinical improvement until the patient's demise from bacteremic vancomycin-resistant enterococcal peritonitis.
|
[
{
"ade": "enterococcal peritonitis",
"drug": "posaconazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Initiation of posaconazole led to clinical improvement until the patient's demise from bacteremic vancomycin-resistant enterococcal peritonitis.",
"role": "user"
},
{
"content": "[{'ade': 'enterococcal peritonitis', 'drug': 'posaconazole'}]",
"role": "assistant"
}
] |
OBJECTIVE: The purpose of this study was to determine whether desensitization to NPH insulin, as well as standard insulin desensitization, could control allergic symptoms in a patient allergic to both NPH and regular insulin.
|
[
{
"ade": "allergic symptoms",
"drug": "insulin"
},
{
"ade": "allergic symptoms",
"drug": "NPH insulin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: The purpose of this study was to determine whether desensitization to NPH insulin, as well as standard insulin desensitization, could control allergic symptoms in a patient allergic to both NPH and regular insulin.",
"role": "user"
},
{
"content": "[{'ade': 'allergic symptoms', 'drug': 'insulin'}, {'ade': 'allergic symptoms', 'drug': 'NPH insulin'}]",
"role": "assistant"
}
] |
However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.
|
[
{
"ade": "diabetes mellitus",
"drug": "norethisterone"
},
{
"ade": "impaired glucose tolerance",
"drug": "norethisterone"
},
{
"ade": "gestational diabetes",
"drug": "norethisterone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.",
"role": "user"
},
{
"content": "[{'ade': 'diabetes mellitus', 'drug': 'norethisterone'}, {'ade': 'impaired glucose tolerance', 'drug': 'norethisterone'}, {'ade': 'gestational diabetes', 'drug': 'norethisterone'}]",
"role": "assistant"
}
] |
OBJECTIVES: A delayed stroke-like leukoencephalopathy has been observed in patients receiving methotrexate (MTX) for childhood leukemia.
|
[
{
"ade": "stroke-like leukoencephalopathy",
"drug": "MTX"
},
{
"ade": "stroke-like leukoencephalopathy",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVES: A delayed stroke-like leukoencephalopathy has been observed in patients receiving methotrexate (MTX) for childhood leukemia.",
"role": "user"
},
{
"content": "[{'ade': 'stroke-like leukoencephalopathy', 'drug': 'MTX'}, {'ade': 'stroke-like leukoencephalopathy', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
We report three cases of severe hypocalcaemia associated with i.v. bisphosphonate treatment in patients with multiple myeloma.
|
[
{
"ade": "severe hypocalcaemia",
"drug": "bisphosphonate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report three cases of severe hypocalcaemia associated with i.v. bisphosphonate treatment in patients with multiple myeloma.",
"role": "user"
},
{
"content": "[{'ade': 'severe hypocalcaemia', 'drug': 'bisphosphonate'}]",
"role": "assistant"
}
] |
CASE SUMMARY: A 39-year-old white Jewish schizophrenic man treated with olanzapine developed an elevated serum CK concentration with a peak concentration of 4000 IU/L (normal < 230).
|
[
{
"ade": "elevated serum CK concentration",
"drug": "olanzapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CASE SUMMARY: A 39-year-old white Jewish schizophrenic man treated with olanzapine developed an elevated serum CK concentration with a peak concentration of 4000 IU/L (normal < 230).",
"role": "user"
},
{
"content": "[{'ade': 'elevated serum CK concentration', 'drug': 'olanzapine'}]",
"role": "assistant"
}
] |
We describe a patient who developed HUS after treatment with mitomycin C (total dose 144 mg/m2) due to a carcinoma of the ascending colon.
|
[
{
"ade": "HUS",
"drug": "mitomycin C"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a patient who developed HUS after treatment with mitomycin C (total dose 144 mg/m2) due to a carcinoma of the ascending colon.",
"role": "user"
},
{
"content": "[{'ade': 'HUS', 'drug': 'mitomycin C'}]",
"role": "assistant"
}
] |
The mechanism of the decrease in plasma potassium induced by phosphate treatment was investigated in a 24-year-old hypertensive patient with hypophosphatemic osteomalacia, who was the youngest of four patients, belonging to a 23 number kindred of five generations.
|
[
{
"ade": "decrease in plasma potassium",
"drug": "phosphate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The mechanism of the decrease in plasma potassium induced by phosphate treatment was investigated in a 24-year-old hypertensive patient with hypophosphatemic osteomalacia, who was the youngest of four patients, belonging to a 23 number kindred of five generations.",
"role": "user"
},
{
"content": "[{'ade': 'decrease in plasma potassium', 'drug': 'phosphate'}]",
"role": "assistant"
}
] |
Slow acetylators, who comprise roughly 50% of the South African population, are likely to develop clinical and biochemical features of phenytoin toxicity when this drug is given together with antituberculosis therapy.
|
[
{
"ade": "phenytoin toxicity",
"drug": "phenytoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Slow acetylators, who comprise roughly 50% of the South African population, are likely to develop clinical and biochemical features of phenytoin toxicity when this drug is given together with antituberculosis therapy.",
"role": "user"
},
{
"content": "[{'ade': 'phenytoin toxicity', 'drug': 'phenytoin'}]",
"role": "assistant"
}
] |
A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF.
|
[
{
"ade": "erythematous papular eruption",
"drug": "G-CSF"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF.",
"role": "user"
},
{
"content": "[{'ade': 'erythematous papular eruption', 'drug': 'G-CSF'}]",
"role": "assistant"
}
] |
The pharmacology and toxicology of chloral hydrate are discussed with particular reference to the cardiac arrhythmias that are seen with overdosage.
|
[
{
"ade": "cardiac arrhythmias",
"drug": "chloral hydrate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The pharmacology and toxicology of chloral hydrate are discussed with particular reference to the cardiac arrhythmias that are seen with overdosage.",
"role": "user"
},
{
"content": "[{'ade': 'cardiac arrhythmias', 'drug': 'chloral hydrate'}]",
"role": "assistant"
}
] |
We report here on a heretofore undescribed respiratory syncytial virus (RSV) infection in a patient with a long-standing history of refractory CLL that was treated with fludarabine phosphate.
|
[
{
"ade": "respiratory syncytial virus (RSV) infection",
"drug": "fludarabine phosphate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report here on a heretofore undescribed respiratory syncytial virus (RSV) infection in a patient with a long-standing history of refractory CLL that was treated with fludarabine phosphate.",
"role": "user"
},
{
"content": "[{'ade': 'respiratory syncytial virus (RSV) infection', 'drug': 'fludarabine phosphate'}]",
"role": "assistant"
}
] |
We present a case of respiratory failure occurring in a woman at 16 weeks' gestation who was being treated with nitrofurantoin for a urinary tract infection.
|
[
{
"ade": "respiratory failure",
"drug": "nitrofurantoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present a case of respiratory failure occurring in a woman at 16 weeks' gestation who was being treated with nitrofurantoin for a urinary tract infection.",
"role": "user"
},
{
"content": "[{'ade': 'respiratory failure', 'drug': 'nitrofurantoin'}]",
"role": "assistant"
}
] |
PURPOSE: To investigate the concentration-side effect relationship in a patient with severe acyclovir-induced neurotoxicity and to summarize the information available in the literature about central nervous system side effects due to acyclovir.
|
[
{
"ade": "neurotoxicity",
"drug": "acyclovir"
},
{
"ade": "central nervous system side effects",
"drug": "acyclovir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PURPOSE: To investigate the concentration-side effect relationship in a patient with severe acyclovir-induced neurotoxicity and to summarize the information available in the literature about central nervous system side effects due to acyclovir.",
"role": "user"
},
{
"content": "[{'ade': 'neurotoxicity', 'drug': 'acyclovir'}, {'ade': 'central nervous system side effects', 'drug': 'acyclovir'}]",
"role": "assistant"
}
] |
Gigantomastia induced by bucillamine.
|
[
{
"ade": "Gigantomastia",
"drug": "bucillamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gigantomastia induced by bucillamine.",
"role": "user"
},
{
"content": "[{'ade': 'Gigantomastia', 'drug': 'bucillamine'}]",
"role": "assistant"
}
] |
Because of serious side effects of an increase in the QT interval causing torsades de pointes, dofetilide must be initiated with close monitoring of the QT interval in an inpatient setting.
|
[
{
"ade": "increase in the QT interval",
"drug": "dofetilide"
},
{
"ade": "torsades de pointes",
"drug": "dofetilide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Because of serious side effects of an increase in the QT interval causing torsades de pointes, dofetilide must be initiated with close monitoring of the QT interval in an inpatient setting.",
"role": "user"
},
{
"content": "[{'ade': 'increase in the QT interval', 'drug': 'dofetilide'}, {'ade': 'torsades de pointes', 'drug': 'dofetilide'}]",
"role": "assistant"
}
] |
Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.
|
[
{
"ade": "Anaphylactoid reaction",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.",
"role": "user"
},
{
"content": "[{'ade': 'Anaphylactoid reaction', 'drug': 'methylprednisolone'}]",
"role": "assistant"
}
] |
Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency developed subacute combined degeneration of the spinal cord following nitrous oxide anesthesia.
|
[
{
"ade": "subacute combined degeneration of the spinal cord",
"drug": "nitrous oxide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency developed subacute combined degeneration of the spinal cord following nitrous oxide anesthesia.",
"role": "user"
},
{
"content": "[{'ade': 'subacute combined degeneration of the spinal cord', 'drug': 'nitrous oxide'}]",
"role": "assistant"
}
] |
Cutaneous ulceration: an unusual complication of intravenous pentamidine therapy.
|
[
{
"ade": "Cutaneous ulceration",
"drug": "pentamidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cutaneous ulceration: an unusual complication of intravenous pentamidine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Cutaneous ulceration', 'drug': 'pentamidine'}]",
"role": "assistant"
}
] |
Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.
|
[
{
"ade": "polymyositis",
"drug": "Lupron"
},
{
"ade": "polymyositis",
"drug": "leuprolide acetate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.",
"role": "user"
},
{
"content": "[{'ade': 'polymyositis', 'drug': 'Lupron'}, {'ade': 'polymyositis', 'drug': 'leuprolide acetate'}]",
"role": "assistant"
}
] |
Acute pancreatitis associated with danazol treatment for endometriosis.
|
[
{
"ade": "Acute pancreatitis",
"drug": "danazol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute pancreatitis associated with danazol treatment for endometriosis.",
"role": "user"
},
{
"content": "[{'ade': 'Acute pancreatitis', 'drug': 'danazol'}]",
"role": "assistant"
}
] |
Gemcitabine should be added to the list of drugs known to cause radiation recall.
|
[
{
"ade": "radiation recall",
"drug": "Gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gemcitabine should be added to the list of drugs known to cause radiation recall.",
"role": "user"
},
{
"content": "[{'ade': 'radiation recall', 'drug': 'Gemcitabine'}]",
"role": "assistant"
}
] |
A review of the literature showed no previous description of this pattern in benzodiazepine coma.
|
[
{
"ade": "coma",
"drug": "benzodiazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A review of the literature showed no previous description of this pattern in benzodiazepine coma.",
"role": "user"
},
{
"content": "[{'ade': 'coma', 'drug': 'benzodiazepine'}]",
"role": "assistant"
}
] |
In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.
|
[
{
"ade": "symptoms of toxicity",
"drug": "lamotrigine"
},
{
"ade": "doubling of the lamotrigine blood level",
"drug": "sertraline"
},
{
"ade": "doubling of the lamotrigine blood level",
"drug": "desmethylsertraline"
},
{
"ade": "doubling of the lamotrigine blood level",
"drug": "lamotrigine"
},
{
"ade": "symptoms of toxicity",
"drug": "desmethylsertraline"
},
{
"ade": "symptoms of toxicity",
"drug": "sertraline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.",
"role": "user"
},
{
"content": "[{'ade': 'symptoms of toxicity', 'drug': 'lamotrigine'}, {'ade': 'doubling of the lamotrigine blood level', 'drug': 'sertraline'}, {'ade': 'doubling of the lamotrigine blood level', 'drug': 'desmethylsertraline'}, {'ade': 'doubling of the lamotrigine blood level', 'drug': 'lamotrigine'}, {'ade': 'symptoms of toxicity', 'drug': 'desmethylsertraline'}, {'ade': 'symptoms of toxicity', 'drug': 'sertraline'}]",
"role": "assistant"
}
] |
Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.
|
[
{
"ade": "Pleuropulmonary fibrosis",
"drug": "pergolide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.",
"role": "user"
},
{
"content": "[{'ade': 'Pleuropulmonary fibrosis', 'drug': 'pergolide'}]",
"role": "assistant"
}
] |
Under the suspicion of amiodarone-induced acute pancreatitis, amiodarone was substituted by propafenone.
|
[
{
"ade": "acute pancreatitis",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Under the suspicion of amiodarone-induced acute pancreatitis, amiodarone was substituted by propafenone.",
"role": "user"
},
{
"content": "[{'ade': 'acute pancreatitis', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked.
|
[
{
"ade": "optic neuropathy",
"drug": "ethambutol"
},
{
"ade": "ocular toxicity",
"drug": "isoniazid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked.",
"role": "user"
},
{
"content": "[{'ade': 'optic neuropathy', 'drug': 'ethambutol'}, {'ade': 'ocular toxicity', 'drug': 'isoniazid'}]",
"role": "assistant"
}
] |
This treatment has the potential to cause severe vision loss as a result of intractable corticosteroid-induced glaucoma.
|
[
{
"ade": "glaucoma",
"drug": "corticosteroid"
},
{
"ade": "severe vision loss",
"drug": "corticosteroid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This treatment has the potential to cause severe vision loss as a result of intractable corticosteroid-induced glaucoma.",
"role": "user"
},
{
"content": "[{'ade': 'glaucoma', 'drug': 'corticosteroid'}, {'ade': 'severe vision loss', 'drug': 'corticosteroid'}]",
"role": "assistant"
}
] |
Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.
|
[
{
"ade": "pulmonary toxicity",
"drug": "docetaxel"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.",
"role": "user"
},
{
"content": "[{'ade': 'pulmonary toxicity', 'drug': 'docetaxel'}]",
"role": "assistant"
}
] |
Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.
|
[
{
"ade": "encephalopathy",
"drug": "risperidone"
},
{
"ade": "worsened motorically",
"drug": "risperidone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.",
"role": "user"
},
{
"content": "[{'ade': 'encephalopathy', 'drug': 'risperidone'}, {'ade': 'worsened motorically', 'drug': 'risperidone'}]",
"role": "assistant"
}
] |
Probable enoxaparin-induced hepatotoxicity.
|
[
{
"ade": "hepatotoxicity",
"drug": "enoxaparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Probable enoxaparin-induced hepatotoxicity.",
"role": "user"
},
{
"content": "[{'ade': 'hepatotoxicity', 'drug': 'enoxaparin'}]",
"role": "assistant"
}
] |
A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.
|
[
{
"ade": "proteinuria",
"drug": "temsirolimus"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.",
"role": "user"
},
{
"content": "[{'ade': 'proteinuria', 'drug': 'temsirolimus'}]",
"role": "assistant"
}
] |
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