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The spectrum of nitrofurantoin lung injury continues to widen.
|
[
{
"ade": "lung injury",
"drug": "nitrofurantoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The spectrum of nitrofurantoin lung injury continues to widen.",
"role": "user"
},
{
"content": "[{'ade': 'lung injury', 'drug': 'nitrofurantoin'}]",
"role": "assistant"
}
] |
Long lasting respiratory depression induced by morphine-6-glucuronide?
|
[
{
"ade": "respiratory depression",
"drug": "morphine-6-glucuronide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Long lasting respiratory depression induced by morphine-6-glucuronide?",
"role": "user"
},
{
"content": "[{'ade': 'respiratory depression', 'drug': 'morphine-6-glucuronide'}]",
"role": "assistant"
}
] |
A case is reported of an elderly woman who developed febrile agranulocytosis several weeks after commencing ticlopidine but who had a favorable outcome after cessation of that drug and treatment with filgastrim.
|
[
{
"ade": "febrile agranulocytosis",
"drug": "ticlopidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case is reported of an elderly woman who developed febrile agranulocytosis several weeks after commencing ticlopidine but who had a favorable outcome after cessation of that drug and treatment with filgastrim.",
"role": "user"
},
{
"content": "[{'ade': 'febrile agranulocytosis', 'drug': 'ticlopidine'}]",
"role": "assistant"
}
] |
Within 6 months of pranlukast withdrawal, anemia resolved and urinary sediment and renal function normalized.
|
[
{
"ade": "anemia",
"drug": "pranlukast"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Within 6 months of pranlukast withdrawal, anemia resolved and urinary sediment and renal function normalized.",
"role": "user"
},
{
"content": "[{'ade': 'anemia', 'drug': 'pranlukast'}]",
"role": "assistant"
}
] |
When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.
|
[
{
"ade": "worsening of the dysesthesia",
"drug": "5-aminosalicylic acid"
},
{
"ade": "weakness",
"drug": "5-ASA"
},
{
"ade": "atrophy",
"drug": "5-ASA"
},
{
"ade": "weakness",
"drug": "5-aminosalicylic acid"
},
{
"ade": "gait disturbance",
"drug": "5-ASA"
},
{
"ade": "gait disturbance",
"drug": "5-aminosalicylic acid"
},
{
"ade": "worsening of the dysesthesia",
"drug": "5-ASA"
},
{
"ade": "atrophy",
"drug": "5-aminosalicylic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.",
"role": "user"
},
{
"content": "[{'ade': 'worsening of the dysesthesia', 'drug': '5-aminosalicylic acid'}, {'ade': 'weakness', 'drug': '5-ASA'}, {'ade': 'atrophy', 'drug': '5-ASA'}, {'ade': 'weakness', 'drug': '5-aminosalicylic acid'}, {'ade': 'gait disturbance', 'drug': '5-ASA'}, {'ade': 'gait disturbance', 'drug': '5-aminosalicylic acid'}, {'ade': 'worsening of the dysesthesia', 'drug': '5-ASA'}, {'ade': 'atrophy', 'drug': '5-aminosalicylic acid'}]",
"role": "assistant"
}
] |
Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.
|
[
{
"ade": "protamine hypersensitivity",
"drug": "neutral protamine Hagedorn (NPH) insulin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.",
"role": "user"
},
{
"content": "[{'ade': 'protamine hypersensitivity', 'drug': 'neutral protamine Hagedorn (NPH) insulin'}]",
"role": "assistant"
}
] |
Despite administration of phenytoin and lorazepam, the seizures persisted and occurred only during amphotercin B administration.
|
[
{
"ade": "seizures",
"drug": "amphotercin B"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Despite administration of phenytoin and lorazepam, the seizures persisted and occurred only during amphotercin B administration.",
"role": "user"
},
{
"content": "[{'ade': 'seizures', 'drug': 'amphotercin B'}]",
"role": "assistant"
}
] |
Does acyclovir increase serum lithium levels?
|
[
{
"ade": "increase serum lithium levels",
"drug": "acyclovir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Does acyclovir increase serum lithium levels?",
"role": "user"
},
{
"content": "[{'ade': 'increase serum lithium levels', 'drug': 'acyclovir'}]",
"role": "assistant"
}
] |
Prolonged severe cholestasis induced by oxacillin derivatives.
|
[
{
"ade": "severe cholestasis",
"drug": "oxacillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Prolonged severe cholestasis induced by oxacillin derivatives.",
"role": "user"
},
{
"content": "[{'ade': 'severe cholestasis', 'drug': 'oxacillin'}]",
"role": "assistant"
}
] |
OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.
|
[
{
"ade": "serotonin syndrome",
"drug": "citalopram"
},
{
"ade": "serotonin syndrome",
"drug": "fentanyl"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.",
"role": "user"
},
{
"content": "[{'ade': 'serotonin syndrome', 'drug': 'citalopram'}, {'ade': 'serotonin syndrome', 'drug': 'fentanyl'}]",
"role": "assistant"
}
] |
Tegaserod-associated ischemic colitis.
|
[
{
"ade": "ischemic colitis",
"drug": "Tegaserod"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Tegaserod-associated ischemic colitis.",
"role": "user"
},
{
"content": "[{'ade': 'ischemic colitis', 'drug': 'Tegaserod'}]",
"role": "assistant"
}
] |
Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity.
|
[
{
"ade": "hepatotoxicity",
"drug": "Interferon-beta"
},
{
"ade": "hepatotoxicity",
"drug": "IFN beta"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity.",
"role": "user"
},
{
"content": "[{'ade': 'hepatotoxicity', 'drug': 'Interferon-beta'}, {'ade': 'hepatotoxicity', 'drug': 'IFN beta'}]",
"role": "assistant"
}
] |
Anaphylaxis to calcitonin.
|
[
{
"ade": "Anaphylaxis",
"drug": "calcitonin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Anaphylaxis to calcitonin.",
"role": "user"
},
{
"content": "[{'ade': 'Anaphylaxis', 'drug': 'calcitonin'}]",
"role": "assistant"
}
] |
Methadone-induced myoclonus in advanced cancer.
|
[
{
"ade": "myoclonus",
"drug": "Methadone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methadone-induced myoclonus in advanced cancer.",
"role": "user"
},
{
"content": "[{'ade': 'myoclonus', 'drug': 'Methadone'}]",
"role": "assistant"
}
] |
Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.
|
[
{
"ade": "hypokalemia",
"drug": "vinorelbine"
},
{
"ade": "SIADH",
"drug": "vinorelbine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.",
"role": "user"
},
{
"content": "[{'ade': 'hypokalemia', 'drug': 'vinorelbine'}, {'ade': 'SIADH', 'drug': 'vinorelbine'}]",
"role": "assistant"
}
] |
Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.
|
[
{
"ade": "death",
"drug": "Fluoxetine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.",
"role": "user"
},
{
"content": "[{'ade': 'death', 'drug': 'Fluoxetine'}]",
"role": "assistant"
}
] |
Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.
|
[
{
"ade": "hepatic impairment",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.",
"role": "user"
},
{
"content": "[{'ade': 'hepatic impairment', 'drug': 'propylthiouracil'}]",
"role": "assistant"
}
] |
This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.
|
[
{
"ade": "multiple nodules in the liver",
"drug": "phosphate diethylstilbestrol"
},
{
"ade": "multiple nodules in the liver",
"drug": "PDES"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.",
"role": "user"
},
{
"content": "[{'ade': 'multiple nodules in the liver', 'drug': 'phosphate diethylstilbestrol'}, {'ade': 'multiple nodules in the liver', 'drug': 'PDES'}]",
"role": "assistant"
}
] |
A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported.
|
[
{
"ade": "erythroderma",
"drug": "dapsone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported.",
"role": "user"
},
{
"content": "[{'ade': 'erythroderma', 'drug': 'dapsone'}]",
"role": "assistant"
}
] |
Amphotericin B-induced seizures in a patient with AIDS.
|
[
{
"ade": "seizures",
"drug": "Amphotericin B"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Amphotericin B-induced seizures in a patient with AIDS.",
"role": "user"
},
{
"content": "[{'ade': 'seizures', 'drug': 'Amphotericin B'}]",
"role": "assistant"
}
] |
A rechallenge, performed in both patients, confirmed the diagnosis of mesalamine-induced pancreatitis.
|
[
{
"ade": "pancreatitis",
"drug": "mesalamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A rechallenge, performed in both patients, confirmed the diagnosis of mesalamine-induced pancreatitis.",
"role": "user"
},
{
"content": "[{'ade': 'pancreatitis', 'drug': 'mesalamine'}]",
"role": "assistant"
}
] |
Anaphylactoid reaction to 50% solution of dextrose.
|
[
{
"ade": "Anaphylactoid reaction",
"drug": "dextrose"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Anaphylactoid reaction to 50% solution of dextrose.",
"role": "user"
},
{
"content": "[{'ade': 'Anaphylactoid reaction', 'drug': 'dextrose'}]",
"role": "assistant"
}
] |
We suggest that the previous classification of nitrofurantoin induced lung injury into "acute" and "chronic" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.
|
[
{
"ade": "nitrofurantoin induced lung injury",
"drug": "nitrofurantoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We suggest that the previous classification of nitrofurantoin induced lung injury into \"acute\" and \"chronic\" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.",
"role": "user"
},
{
"content": "[{'ade': 'nitrofurantoin induced lung injury', 'drug': 'nitrofurantoin'}]",
"role": "assistant"
}
] |
Six days after starting acyclovir she exhibited signs of lithium toxicity.
|
[
{
"ade": "lithium toxicity",
"drug": "lithium"
},
{
"ade": "lithium toxicity",
"drug": "acyclovir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Six days after starting acyclovir she exhibited signs of lithium toxicity.",
"role": "user"
},
{
"content": "[{'ade': 'lithium toxicity', 'drug': 'lithium'}, {'ade': 'lithium toxicity', 'drug': 'acyclovir'}]",
"role": "assistant"
}
] |
Two patients are described in whom subtle cognitive impairments are associated with therapeutic doses of amoxapine.
|
[
{
"ade": "cognitive impairments",
"drug": "amoxapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two patients are described in whom subtle cognitive impairments are associated with therapeutic doses of amoxapine.",
"role": "user"
},
{
"content": "[{'ade': 'cognitive impairments', 'drug': 'amoxapine'}]",
"role": "assistant"
}
] |
Paraplegia following prophylactic intrathecal cytosine arabinoside (Ara-C) is described in a patient with acute myelogenous leukemia in remission who received doses of 100 mg/m2/d for 5 consecutive days.
|
[
{
"ade": "Paraplegia",
"drug": "Ara-C"
},
{
"ade": "Paraplegia",
"drug": "cytosine arabinoside"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Paraplegia following prophylactic intrathecal cytosine arabinoside (Ara-C) is described in a patient with acute myelogenous leukemia in remission who received doses of 100 mg/m2/d for 5 consecutive days.",
"role": "user"
},
{
"content": "[{'ade': 'Paraplegia', 'drug': 'Ara-C'}, {'ade': 'Paraplegia', 'drug': 'cytosine arabinoside'}]",
"role": "assistant"
}
] |
We report a case of a 23-year-old man who developed a vancomycin-induced anaphylactic reaction in the treatment of methicillin-resistant Staphylococcus aureus infection.
|
[
{
"ade": "anaphylactic reaction",
"drug": "vancomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of a 23-year-old man who developed a vancomycin-induced anaphylactic reaction in the treatment of methicillin-resistant Staphylococcus aureus infection.",
"role": "user"
},
{
"content": "[{'ade': 'anaphylactic reaction', 'drug': 'vancomycin'}]",
"role": "assistant"
}
] |
This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.
|
[
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.",
"role": "user"
},
{
"content": "[{'ade': 'toxic epidermal necrolysis', 'drug': 'ofloxacin'}]",
"role": "assistant"
}
] |
Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.
|
[
{
"ade": "sensorineural hearing loss",
"drug": "Propylthiouracil"
},
{
"ade": "antineutrophil cytoplasmic antibodies",
"drug": "Propylthiouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.",
"role": "user"
},
{
"content": "[{'ade': 'sensorineural hearing loss', 'drug': 'Propylthiouracil'}, {'ade': 'antineutrophil cytoplasmic antibodies', 'drug': 'Propylthiouracil'}]",
"role": "assistant"
}
] |
Ramipril-induced cutaneous vasculitis is particularly rare and our case was atypical because the patient had tolerated lisinopril before.
|
[
{
"ade": "cutaneous vasculitis",
"drug": "Ramipril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ramipril-induced cutaneous vasculitis is particularly rare and our case was atypical because the patient had tolerated lisinopril before.",
"role": "user"
},
{
"content": "[{'ade': 'cutaneous vasculitis', 'drug': 'Ramipril'}]",
"role": "assistant"
}
] |
The patient's other comorbidities and medications have not been suggested as possible interactions with sertraline that can cause rhabdomyolysis.
|
[
{
"ade": "rhabdomyolysis",
"drug": "sertraline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient's other comorbidities and medications have not been suggested as possible interactions with sertraline that can cause rhabdomyolysis.",
"role": "user"
},
{
"content": "[{'ade': 'rhabdomyolysis', 'drug': 'sertraline'}]",
"role": "assistant"
}
] |
Vancomycin-induced vasculitis.
|
[
{
"ade": "vasculitis",
"drug": "Vancomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Vancomycin-induced vasculitis.",
"role": "user"
},
{
"content": "[{'ade': 'vasculitis', 'drug': 'Vancomycin'}]",
"role": "assistant"
}
] |
Treatment of lithium tremor with metoprolol.
|
[
{
"ade": "tremor",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Treatment of lithium tremor with metoprolol.",
"role": "user"
},
{
"content": "[{'ade': 'tremor', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
RESULTS: Two patients with ocular inflammation of unknown origin developed severe chorioretinitis after IVTA injection.
|
[
{
"ade": "severe chorioretinitis",
"drug": "IVTA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: Two patients with ocular inflammation of unknown origin developed severe chorioretinitis after IVTA injection.",
"role": "user"
},
{
"content": "[{'ade': 'severe chorioretinitis', 'drug': 'IVTA'}]",
"role": "assistant"
}
] |
After several unrevealing medical work-ups, he was found to have a high blood lead level (122 microg/dL); he has a history of scraping and sanding lead paint without adequate protective measures.
|
[
{
"ade": "high blood lead level",
"drug": "lead"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After several unrevealing medical work-ups, he was found to have a high blood lead level (122 microg/dL); he has a history of scraping and sanding lead paint without adequate protective measures.",
"role": "user"
},
{
"content": "[{'ade': 'high blood lead level', 'drug': 'lead'}]",
"role": "assistant"
}
] |
This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.
|
[
{
"ade": "acute hemoglobinemia",
"drug": "anti-D IGIV"
},
{
"ade": "hemoglobinuria",
"drug": "anti-D IGIV"
},
{
"ade": "DIC",
"drug": "anti-D IGIV"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.",
"role": "user"
},
{
"content": "[{'ade': 'acute hemoglobinemia', 'drug': 'anti-D IGIV'}, {'ade': 'hemoglobinuria', 'drug': 'anti-D IGIV'}, {'ade': 'DIC', 'drug': 'anti-D IGIV'}]",
"role": "assistant"
}
] |
This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.
|
[
{
"ade": "extramedullary relapse",
"drug": "ATRA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.",
"role": "user"
},
{
"content": "[{'ade': 'extramedullary relapse', 'drug': 'ATRA'}]",
"role": "assistant"
}
] |
Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.
|
[
{
"ade": "duodenal ulceration",
"drug": "Tolazoline"
},
{
"ade": "intestinal perforation",
"drug": "Tolazoline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.",
"role": "user"
},
{
"content": "[{'ade': 'duodenal ulceration', 'drug': 'Tolazoline'}, {'ade': 'intestinal perforation', 'drug': 'Tolazoline'}]",
"role": "assistant"
}
] |
Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).
|
[
{
"ade": "hemolytic-uremic syndrome",
"drug": "Mitomycin C"
},
{
"ade": "HUS",
"drug": "MMC"
},
{
"ade": "hemolytic-uremic syndrome",
"drug": "MMC"
},
{
"ade": "HUS",
"drug": "Mitomycin C"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).",
"role": "user"
},
{
"content": "[{'ade': 'hemolytic-uremic syndrome', 'drug': 'Mitomycin C'}, {'ade': 'HUS', 'drug': 'MMC'}, {'ade': 'hemolytic-uremic syndrome', 'drug': 'MMC'}, {'ade': 'HUS', 'drug': 'Mitomycin C'}]",
"role": "assistant"
}
] |
Noncardiogenic pulmonary edema during intrabiliary infusion of mono-octanoin.
|
[
{
"ade": "Noncardiogenic pulmonary edema",
"drug": "mono-octanoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Noncardiogenic pulmonary edema during intrabiliary infusion of mono-octanoin.",
"role": "user"
},
{
"content": "[{'ade': 'Noncardiogenic pulmonary edema', 'drug': 'mono-octanoin'}]",
"role": "assistant"
}
] |
Gemcitabine is a known risk factor for hemolytic uremic syndrome (HUS), which can often have a rapidly fatal clinical course despite intervention with steroids, plasmapheresis and hemodialysis.
|
[
{
"ade": "hemolytic uremic syndrome",
"drug": "Gemcitabine"
},
{
"ade": "HUS",
"drug": "Gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gemcitabine is a known risk factor for hemolytic uremic syndrome (HUS), which can often have a rapidly fatal clinical course despite intervention with steroids, plasmapheresis and hemodialysis.",
"role": "user"
},
{
"content": "[{'ade': 'hemolytic uremic syndrome', 'drug': 'Gemcitabine'}, {'ade': 'HUS', 'drug': 'Gemcitabine'}]",
"role": "assistant"
}
] |
Nonconvulsive status epilepticus due to ifosfamide.
|
[
{
"ade": "Nonconvulsive status epilepticus",
"drug": "ifosfamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nonconvulsive status epilepticus due to ifosfamide.",
"role": "user"
},
{
"content": "[{'ade': 'Nonconvulsive status epilepticus', 'drug': 'ifosfamide'}]",
"role": "assistant"
}
] |
A case of recall pneumonitis induced by gemcitabine is reported.
|
[
{
"ade": "recall pneumonitis",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of recall pneumonitis induced by gemcitabine is reported.",
"role": "user"
},
{
"content": "[{'ade': 'recall pneumonitis', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
Ticlopidine is an oral antiplatelet agent frequently utilized in the treatment of cerebrovascular disease and is rarely associated with severe bone marrow suppression, typically aplastic anemia.
|
[
{
"ade": "severe bone marrow suppression",
"drug": "Ticlopidine"
},
{
"ade": "aplastic anemia",
"drug": "Ticlopidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ticlopidine is an oral antiplatelet agent frequently utilized in the treatment of cerebrovascular disease and is rarely associated with severe bone marrow suppression, typically aplastic anemia.",
"role": "user"
},
{
"content": "[{'ade': 'severe bone marrow suppression', 'drug': 'Ticlopidine'}, {'ade': 'aplastic anemia', 'drug': 'Ticlopidine'}]",
"role": "assistant"
}
] |
We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.
|
[
{
"ade": "aspergillus arthritis of the knee joint",
"drug": "fludarabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.",
"role": "user"
},
{
"content": "[{'ade': 'aspergillus arthritis of the knee joint', 'drug': 'fludarabine'}]",
"role": "assistant"
}
] |
Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.
|
[
{
"ade": "neuroleptic malignant syndrome",
"drug": "metoclopramide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.",
"role": "user"
},
{
"content": "[{'ade': 'neuroleptic malignant syndrome', 'drug': 'metoclopramide'}]",
"role": "assistant"
}
] |
Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more.
|
[
{
"ade": "neutropenia",
"drug": "penicillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more.",
"role": "user"
},
{
"content": "[{'ade': 'neutropenia', 'drug': 'penicillin'}]",
"role": "assistant"
}
] |
In the other patient, a 78-year-old woman, Neisseria mucosa knee arthritis occurred after a single sodium hyaluronate injection.
|
[
{
"ade": "Neisseria mucosa knee arthritis",
"drug": "sodium hyaluronate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In the other patient, a 78-year-old woman, Neisseria mucosa knee arthritis occurred after a single sodium hyaluronate injection.",
"role": "user"
},
{
"content": "[{'ade': 'Neisseria mucosa knee arthritis', 'drug': 'sodium hyaluronate'}]",
"role": "assistant"
}
] |
Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.
|
[
{
"ade": "severe hepatotoxic reactions",
"drug": "CPA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.",
"role": "user"
},
{
"content": "[{'ade': 'severe hepatotoxic reactions', 'drug': 'CPA'}]",
"role": "assistant"
}
] |
CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.
|
[
{
"ade": "malignant transformation of endometriosis",
"drug": "Tamoxifen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.",
"role": "user"
},
{
"content": "[{'ade': 'malignant transformation of endometriosis', 'drug': 'Tamoxifen'}]",
"role": "assistant"
}
] |
Psoriasis induced by interferon-alpha.
|
[
{
"ade": "Psoriasis",
"drug": "interferon-alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Psoriasis induced by interferon-alpha.",
"role": "user"
},
{
"content": "[{'ade': 'Psoriasis', 'drug': 'interferon-alpha'}]",
"role": "assistant"
}
] |
It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.
|
[
{
"ade": "VBDS",
"drug": "ciprofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.",
"role": "user"
},
{
"content": "[{'ade': 'VBDS', 'drug': 'ciprofloxacin'}]",
"role": "assistant"
}
] |
In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.
|
[
{
"ade": "acute interstitial nephritis",
"drug": "ampicillin"
},
{
"ade": "exfoliative dermatitis",
"drug": "ampicillin"
},
{
"ade": "renal failure",
"drug": "ampicillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.",
"role": "user"
},
{
"content": "[{'ade': 'acute interstitial nephritis', 'drug': 'ampicillin'}, {'ade': 'exfoliative dermatitis', 'drug': 'ampicillin'}, {'ade': 'renal failure', 'drug': 'ampicillin'}]",
"role": "assistant"
}
] |
Response of a promethazine-induced coma to flumazenil.
|
[
{
"ade": "coma",
"drug": "promethazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Response of a promethazine-induced coma to flumazenil.",
"role": "user"
},
{
"content": "[{'ade': 'coma', 'drug': 'promethazine'}]",
"role": "assistant"
}
] |
They seemed to involve multiple aetiological factors, such as autoimmune thyroid disease, the toxic and immunomodulatory roles of lithium and perhaps genetic and dietary factors.
|
[
{
"ade": "toxic and immunomodulatory roles",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: They seemed to involve multiple aetiological factors, such as autoimmune thyroid disease, the toxic and immunomodulatory roles of lithium and perhaps genetic and dietary factors.",
"role": "user"
},
{
"content": "[{'ade': 'toxic and immunomodulatory roles', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
Lipoid pneumonia: a silent complication of mineral oil aspiration.
|
[
{
"ade": "Lipoid pneumonia",
"drug": "mineral oil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Lipoid pneumonia: a silent complication of mineral oil aspiration.",
"role": "user"
},
{
"content": "[{'ade': 'Lipoid pneumonia', 'drug': 'mineral oil'}]",
"role": "assistant"
}
] |
Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.
|
[
{
"ade": "Multicentric hepatocellular carcinoma",
"drug": "phosphate diethylstilbestrol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.",
"role": "user"
},
{
"content": "[{'ade': 'Multicentric hepatocellular carcinoma', 'drug': 'phosphate diethylstilbestrol'}]",
"role": "assistant"
}
] |
Sunburn may sometimes be a major injury in psoralen users because high doses or inappropriate use of the drug may render the skin extremely sensitive.
|
[
{
"ade": "Sunburn",
"drug": "psoralen"
},
{
"ade": "skin extremely sensitive",
"drug": "psoralen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sunburn may sometimes be a major injury in psoralen users because high doses or inappropriate use of the drug may render the skin extremely sensitive.",
"role": "user"
},
{
"content": "[{'ade': 'Sunburn', 'drug': 'psoralen'}, {'ade': 'skin extremely sensitive', 'drug': 'psoralen'}]",
"role": "assistant"
}
] |
Ototoxicity as a result of cis-platinum administration is well documented.
|
[
{
"ade": "Ototoxicity",
"drug": "cis-platinum"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ototoxicity as a result of cis-platinum administration is well documented.",
"role": "user"
},
{
"content": "[{'ade': 'Ototoxicity', 'drug': 'cis-platinum'}]",
"role": "assistant"
}
] |
We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence.
|
[
{
"ade": "hepatotoxicity",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence.",
"role": "user"
},
{
"content": "[{'ade': 'hepatotoxicity', 'drug': 'methylprednisolone'}]",
"role": "assistant"
}
] |
Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis.
|
[
{
"ade": "fatal pulmonary fibrosis",
"drug": "CCNU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis.",
"role": "user"
},
{
"content": "[{'ade': 'fatal pulmonary fibrosis', 'drug': 'CCNU'}]",
"role": "assistant"
}
] |
In one case, disulfiram was the only potential teratogen exposed to the fetus.
|
[
{
"ade": "teratogen",
"drug": "disulfiram"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In one case, disulfiram was the only potential teratogen exposed to the fetus.",
"role": "user"
},
{
"content": "[{'ade': 'teratogen', 'drug': 'disulfiram'}]",
"role": "assistant"
}
] |
Inappropriate antidiuretic hormone secretion after high dose vinblastine.
|
[
{
"ade": "Inappropriate antidiuretic hormone secretion",
"drug": "vinblastine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Inappropriate antidiuretic hormone secretion after high dose vinblastine.",
"role": "user"
},
{
"content": "[{'ade': 'Inappropriate antidiuretic hormone secretion', 'drug': 'vinblastine'}]",
"role": "assistant"
}
] |
Suspected ciprofloxacin-induced interstitial nephritis.
|
[
{
"ade": "interstitial nephritis",
"drug": "ciprofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Suspected ciprofloxacin-induced interstitial nephritis.",
"role": "user"
},
{
"content": "[{'ade': 'interstitial nephritis', 'drug': 'ciprofloxacin'}]",
"role": "assistant"
}
] |
We describe a 63 year old woman with a suppurative mediastinitis, treated with continuous PI irrigation who developed an acute oliguric renal failure.
|
[
{
"ade": "acute oliguric renal failure",
"drug": "PI"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a 63 year old woman with a suppurative mediastinitis, treated with continuous PI irrigation who developed an acute oliguric renal failure.",
"role": "user"
},
{
"content": "[{'ade': 'acute oliguric renal failure', 'drug': 'PI'}]",
"role": "assistant"
}
] |
RESULTS: The estimated number of Accutane prescriptions for reproductive-aged women has more than doubled in the past 10 years; it is the most widely used teratogenic drug in the United States, with approximately 2.5 per 1,000 reproductive-aged women exposed to Accutane in 1999.
|
[
{
"ade": "teratogenic",
"drug": "Accutane"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: The estimated number of Accutane prescriptions for reproductive-aged women has more than doubled in the past 10 years; it is the most widely used teratogenic drug in the United States, with approximately 2.5 per 1,000 reproductive-aged women exposed to Accutane in 1999.",
"role": "user"
},
{
"content": "[{'ade': 'teratogenic', 'drug': 'Accutane'}]",
"role": "assistant"
}
] |
Catatonia associated with disulfiram therapy.
|
[
{
"ade": "Catatonia",
"drug": "disulfiram"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Catatonia associated with disulfiram therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Catatonia', 'drug': 'disulfiram'}]",
"role": "assistant"
}
] |
One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension.
|
[
{
"ade": "severe hyponatremia",
"drug": "hydrochlorothiazide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension.",
"role": "user"
},
{
"content": "[{'ade': 'severe hyponatremia', 'drug': 'hydrochlorothiazide'}]",
"role": "assistant"
}
] |
Suxamethonium apnoea terminated with commercial serumcholinesterase.
|
[
{
"ade": "apnoea",
"drug": "Suxamethonium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Suxamethonium apnoea terminated with commercial serumcholinesterase.",
"role": "user"
},
{
"content": "[{'ade': 'apnoea', 'drug': 'Suxamethonium'}]",
"role": "assistant"
}
] |
Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.
|
[
{
"ade": "pneumonitis",
"drug": "Methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.",
"role": "user"
},
{
"content": "[{'ade': 'pneumonitis', 'drug': 'Methotrexate'}]",
"role": "assistant"
}
] |
Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.
|
[
{
"ade": "severe skin rash",
"drug": "methotrexate"
},
{
"ade": "Bone marrow aplasia",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.",
"role": "user"
},
{
"content": "[{'ade': 'severe skin rash', 'drug': 'methotrexate'}, {'ade': 'Bone marrow aplasia', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Persistent hypoglycemia in a patient with diabetes taking etanercept for the treatment of psoriasis.
|
[
{
"ade": "Persistent hypoglycemia",
"drug": "etanercept"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Persistent hypoglycemia in a patient with diabetes taking etanercept for the treatment of psoriasis.",
"role": "user"
},
{
"content": "[{'ade': 'Persistent hypoglycemia', 'drug': 'etanercept'}]",
"role": "assistant"
}
] |
Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).
|
[
{
"ade": "TD",
"drug": "Risperidone"
},
{
"ade": "tardive dyskinesia",
"drug": "Risperidone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).",
"role": "user"
},
{
"content": "[{'ade': 'TD', 'drug': 'Risperidone'}, {'ade': 'tardive dyskinesia', 'drug': 'Risperidone'}]",
"role": "assistant"
}
] |
We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI).
|
[
{
"ade": "fulminant hepatic failure",
"drug": "ddI"
},
{
"ade": "fulminant hepatic failure",
"drug": "didanosine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI).",
"role": "user"
},
{
"content": "[{'ade': 'fulminant hepatic failure', 'drug': 'ddI'}, {'ade': 'fulminant hepatic failure', 'drug': 'didanosine'}]",
"role": "assistant"
}
] |
The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.
|
[
{
"ade": "hypertension",
"drug": "sunitinib"
},
{
"ade": "fatigue",
"drug": "sunitinib"
},
{
"ade": "elevated lipase",
"drug": "sunitinib"
},
{
"ade": "hand-foot syndrome",
"drug": "sunitinib"
},
{
"ade": "lymphopenia",
"drug": "sunitinib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.",
"role": "user"
},
{
"content": "[{'ade': 'hypertension', 'drug': 'sunitinib'}, {'ade': 'fatigue', 'drug': 'sunitinib'}, {'ade': 'elevated lipase', 'drug': 'sunitinib'}, {'ade': 'hand-foot syndrome', 'drug': 'sunitinib'}, {'ade': 'lymphopenia', 'drug': 'sunitinib'}]",
"role": "assistant"
}
] |
Anterior spinal artery syndrome--a complication of cervical intrathecal phenol injection.
|
[
{
"ade": "Anterior spinal artery syndrome",
"drug": "phenol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Anterior spinal artery syndrome--a complication of cervical intrathecal phenol injection.",
"role": "user"
},
{
"content": "[{'ade': 'Anterior spinal artery syndrome', 'drug': 'phenol'}]",
"role": "assistant"
}
] |
The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.
|
[
{
"ade": "radiation recall",
"drug": "gemcitabine"
},
{
"ade": "myositis",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.",
"role": "user"
},
{
"content": "[{'ade': 'radiation recall', 'drug': 'gemcitabine'}, {'ade': 'myositis', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
Sensorimotor polyneuropathy with 5-aminosalicylic acid: a case report.
|
[
{
"ade": "Sensorimotor polyneuropathy",
"drug": "5-aminosalicylic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sensorimotor polyneuropathy with 5-aminosalicylic acid: a case report.",
"role": "user"
},
{
"content": "[{'ade': 'Sensorimotor polyneuropathy', 'drug': '5-aminosalicylic acid'}]",
"role": "assistant"
}
] |
Diarrhea-associated over-anticoagulation in a patient taking warfarin: therapeutic role of cholestyramine.
|
[
{
"ade": "Diarrhea-associated over-anticoagulation",
"drug": "warfarin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Diarrhea-associated over-anticoagulation in a patient taking warfarin: therapeutic role of cholestyramine.",
"role": "user"
},
{
"content": "[{'ade': 'Diarrhea-associated over-anticoagulation', 'drug': 'warfarin'}]",
"role": "assistant"
}
] |
Both 6-MP and AZA are widely used and are known to cause hepatotoxicity in a proportion of patients.
|
[
{
"ade": "hepatotoxicity",
"drug": "6-MP"
},
{
"ade": "hepatotoxicity",
"drug": "AZA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Both 6-MP and AZA are widely used and are known to cause hepatotoxicity in a proportion of patients.",
"role": "user"
},
{
"content": "[{'ade': 'hepatotoxicity', 'drug': '6-MP'}, {'ade': 'hepatotoxicity', 'drug': 'AZA'}]",
"role": "assistant"
}
] |
METHODS: Growth retardation was observed in six severely asthmatic children after introduction of high-dose fluticasone propionate treatment (dry powder).
|
[
{
"ade": "Growth retardation",
"drug": "fluticasone propionate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: METHODS: Growth retardation was observed in six severely asthmatic children after introduction of high-dose fluticasone propionate treatment (dry powder).",
"role": "user"
},
{
"content": "[{'ade': 'Growth retardation', 'drug': 'fluticasone propionate'}]",
"role": "assistant"
}
] |
Linear immunoglobulin A bullous dermatosis induced by gemcitabine.
|
[
{
"ade": "Linear immunoglobulin A bullous dermatosis",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Linear immunoglobulin A bullous dermatosis induced by gemcitabine.",
"role": "user"
},
{
"content": "[{'ade': 'Linear immunoglobulin A bullous dermatosis', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
Hydroxyurea (HU) and sodium phenylbutyrate (SPB) have been shown to increase fetal hemoglobin (Hb F) levels in patients with thalassemia intermedia.
|
[
{
"ade": "increase fetal hemoglobin",
"drug": "sodium phenylbutyrate"
},
{
"ade": "increase fetal hemoglobin",
"drug": "Hydroxyurea"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hydroxyurea (HU) and sodium phenylbutyrate (SPB) have been shown to increase fetal hemoglobin (Hb F) levels in patients with thalassemia intermedia.",
"role": "user"
},
{
"content": "[{'ade': 'increase fetal hemoglobin', 'drug': 'sodium phenylbutyrate'}, {'ade': 'increase fetal hemoglobin', 'drug': 'Hydroxyurea'}]",
"role": "assistant"
}
] |
The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.
|
[
{
"ade": "myocardial infarction",
"drug": "etoposide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.",
"role": "user"
},
{
"content": "[{'ade': 'myocardial infarction', 'drug': 'etoposide'}]",
"role": "assistant"
}
] |
PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.
|
[
{
"ade": "lethal adverse reactions",
"drug": "5-fluorouracil"
},
{
"ade": "lethal adverse reactions",
"drug": "5-FU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.",
"role": "user"
},
{
"content": "[{'ade': 'lethal adverse reactions', 'drug': '5-fluorouracil'}, {'ade': 'lethal adverse reactions', 'drug': '5-FU'}]",
"role": "assistant"
}
] |
Bleomycin induced hyperpigmentation with yolk sac tumor.
|
[
{
"ade": "hyperpigmentation",
"drug": "Bleomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Bleomycin induced hyperpigmentation with yolk sac tumor.",
"role": "user"
},
{
"content": "[{'ade': 'hyperpigmentation', 'drug': 'Bleomycin'}]",
"role": "assistant"
}
] |
The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease.
|
[
{
"ade": "lung disease",
"drug": "cyclophosphamide"
},
{
"ade": "respiratory insufficiency",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease.",
"role": "user"
},
{
"content": "[{'ade': 'lung disease', 'drug': 'cyclophosphamide'}, {'ade': 'respiratory insufficiency', 'drug': 'cyclophosphamide'}]",
"role": "assistant"
}
] |
Jaundice induced by streptokinase.
|
[
{
"ade": "Jaundice",
"drug": "streptokinase"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Jaundice induced by streptokinase.",
"role": "user"
},
{
"content": "[{'ade': 'Jaundice', 'drug': 'streptokinase'}]",
"role": "assistant"
}
] |
However, acute cardiomyopathy and pericarditis secondary to methylphenidate use has been rarely reported.
|
[
{
"ade": "pericarditis",
"drug": "methylphenidate"
},
{
"ade": "acute cardiomyopathy",
"drug": "methylphenidate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, acute cardiomyopathy and pericarditis secondary to methylphenidate use has been rarely reported.",
"role": "user"
},
{
"content": "[{'ade': 'pericarditis', 'drug': 'methylphenidate'}, {'ade': 'acute cardiomyopathy', 'drug': 'methylphenidate'}]",
"role": "assistant"
}
] |
Thus cabergoline may cause similar pleuropulmonary abnormalities to bromocriptine.
|
[
{
"ade": "pleuropulmonary abnormalities",
"drug": "bromocriptine"
},
{
"ade": "pleuropulmonary abnormalities",
"drug": "cabergoline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thus cabergoline may cause similar pleuropulmonary abnormalities to bromocriptine.",
"role": "user"
},
{
"content": "[{'ade': 'pleuropulmonary abnormalities', 'drug': 'bromocriptine'}, {'ade': 'pleuropulmonary abnormalities', 'drug': 'cabergoline'}]",
"role": "assistant"
}
] |
Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.
|
[
{
"ade": "glaucoma",
"drug": "steroid"
},
{
"ade": "glaucoma",
"drug": "triamcinolone acetonide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.",
"role": "user"
},
{
"content": "[{'ade': 'glaucoma', 'drug': 'steroid'}, {'ade': 'glaucoma', 'drug': 'triamcinolone acetonide'}]",
"role": "assistant"
}
] |
We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment.
|
[
{
"ade": "hair loss",
"drug": "paroxetine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment.",
"role": "user"
},
{
"content": "[{'ade': 'hair loss', 'drug': 'paroxetine'}]",
"role": "assistant"
}
] |
A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger.
|
[
{
"ade": "angioedema",
"drug": "oxcarbazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger.",
"role": "user"
},
{
"content": "[{'ade': 'angioedema', 'drug': 'oxcarbazepine'}]",
"role": "assistant"
}
] |
A possible case of carbamazepine induced pancreatitis.
|
[
{
"ade": "pancreatitis",
"drug": "carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A possible case of carbamazepine induced pancreatitis.",
"role": "user"
},
{
"content": "[{'ade': 'pancreatitis', 'drug': 'carbamazepine'}]",
"role": "assistant"
}
] |
CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.
|
[
{
"ade": "acute hepatitis",
"drug": "itraconazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.",
"role": "user"
},
{
"content": "[{'ade': 'acute hepatitis', 'drug': 'itraconazole'}]",
"role": "assistant"
}
] |
We report AZA-induced drug eruption that developed in two cases of systemic scleroderma with polymyositis.
|
[
{
"ade": "drug eruption",
"drug": "AZA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report AZA-induced drug eruption that developed in two cases of systemic scleroderma with polymyositis.",
"role": "user"
},
{
"content": "[{'ade': 'drug eruption', 'drug': 'AZA'}]",
"role": "assistant"
}
] |
Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient.
|
[
{
"ade": "neuroleptic malignant syndrome",
"drug": "Fluphenazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient.",
"role": "user"
},
{
"content": "[{'ade': 'neuroleptic malignant syndrome', 'drug': 'Fluphenazine'}]",
"role": "assistant"
}
] |
Thalidomide was withdrawn from world markets in 1961 following recognition of its teratogenic effects.
|
[
{
"ade": "teratogenic effects",
"drug": "Thalidomide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thalidomide was withdrawn from world markets in 1961 following recognition of its teratogenic effects.",
"role": "user"
},
{
"content": "[{'ade': 'teratogenic effects', 'drug': 'Thalidomide'}]",
"role": "assistant"
}
] |
The renal consequences of indinavir-associated nephrotoxicity are uncertain.
|
[
{
"ade": "nephrotoxicity",
"drug": "indinavir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The renal consequences of indinavir-associated nephrotoxicity are uncertain.",
"role": "user"
},
{
"content": "[{'ade': 'nephrotoxicity', 'drug': 'indinavir'}]",
"role": "assistant"
}
] |
We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene, which is also a selective estrogen receptor modulator.
|
[
{
"ade": "malignant mixed mesodermal tumor",
"drug": "raloxifene"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene, which is also a selective estrogen receptor modulator.",
"role": "user"
},
{
"content": "[{'ade': 'malignant mixed mesodermal tumor', 'drug': 'raloxifene'}]",
"role": "assistant"
}
] |
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