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Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.
|
[
{
"ade": "diabetes insipidus",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.",
"role": "user"
},
{
"content": "[{'ade': 'diabetes insipidus', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
Mental nerve neuropathy as a result of hepatitis B vaccination.
|
[
{
"ade": "Mental nerve neuropathy",
"drug": "hepatitis B vaccination"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Mental nerve neuropathy as a result of hepatitis B vaccination.",
"role": "user"
},
{
"content": "[{'ade': 'Mental nerve neuropathy', 'drug': 'hepatitis B vaccination'}]",
"role": "assistant"
}
] |
Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.
|
[
{
"ade": "severe hypersensitivity",
"drug": "carboplatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.",
"role": "user"
},
{
"content": "[{'ade': 'severe hypersensitivity', 'drug': 'carboplatin'}]",
"role": "assistant"
}
] |
Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).
|
[
{
"ade": "diabetes",
"drug": "indapamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).",
"role": "user"
},
{
"content": "[{'ade': 'diabetes', 'drug': 'indapamide'}]",
"role": "assistant"
}
] |
The role of Adriamycin in the production of cardiotoxicity is reviewed.
|
[
{
"ade": "cardiotoxicity",
"drug": "Adriamycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The role of Adriamycin in the production of cardiotoxicity is reviewed.",
"role": "user"
},
{
"content": "[{'ade': 'cardiotoxicity', 'drug': 'Adriamycin'}]",
"role": "assistant"
}
] |
Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.
|
[
{
"ade": "Growth and adrenal suppression",
"drug": "fluticasone propionate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.",
"role": "user"
},
{
"content": "[{'ade': 'Growth and adrenal suppression', 'drug': 'fluticasone propionate'}]",
"role": "assistant"
}
] |
Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.
|
[
{
"ade": "hypoadrenalism",
"drug": "o,p'-DDD"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.",
"role": "user"
},
{
"content": "[{'ade': 'hypoadrenalism', 'drug': \"o,p'-DDD\"}]",
"role": "assistant"
}
] |
A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.
|
[
{
"ade": "myoclonus",
"drug": "methadone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.",
"role": "user"
},
{
"content": "[{'ade': 'myoclonus', 'drug': 'methadone'}]",
"role": "assistant"
}
] |
In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.
|
[
{
"ade": "severe systemic CMV infection",
"drug": "cyclosporine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.",
"role": "user"
},
{
"content": "[{'ade': 'severe systemic CMV infection', 'drug': 'cyclosporine'}]",
"role": "assistant"
}
] |
OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).
|
[
{
"ade": "myopathy",
"drug": "colchicine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).",
"role": "user"
},
{
"content": "[{'ade': 'myopathy', 'drug': 'colchicine'}]",
"role": "assistant"
}
] |
Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.
|
[
{
"ade": "SJS",
"drug": "nevirapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.",
"role": "user"
},
{
"content": "[{'ade': 'SJS', 'drug': 'nevirapine'}]",
"role": "assistant"
}
] |
The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.
|
[
{
"ade": "fungal infections",
"drug": "alemtuzumab"
},
{
"ade": "opportunistic infections",
"drug": "alemtuzumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.",
"role": "user"
},
{
"content": "[{'ade': 'fungal infections', 'drug': 'alemtuzumab'}, {'ade': 'opportunistic infections', 'drug': 'alemtuzumab'}]",
"role": "assistant"
}
] |
It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.
|
[
{
"ade": "cerebral atrophy",
"drug": "ACTH"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.",
"role": "user"
},
{
"content": "[{'ade': 'cerebral atrophy', 'drug': 'ACTH'}]",
"role": "assistant"
}
] |
To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.
|
[
{
"ade": "irreversible renal failure",
"drug": "TDF"
},
{
"ade": "rickets",
"drug": "TDF"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.",
"role": "user"
},
{
"content": "[{'ade': 'irreversible renal failure', 'drug': 'TDF'}, {'ade': 'rickets', 'drug': 'TDF'}]",
"role": "assistant"
}
] |
Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.
|
[
{
"ade": "acute intermittent porphyria",
"drug": "Diphenylhydantoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.",
"role": "user"
},
{
"content": "[{'ade': 'acute intermittent porphyria', 'drug': 'Diphenylhydantoin'}]",
"role": "assistant"
}
] |
We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).
|
[
{
"ade": "rhinitis",
"drug": "calcitonin"
},
{
"ade": "perspiration",
"drug": "calcitonin"
},
{
"ade": "conjunctivitis",
"drug": "Calsynar"
},
{
"ade": "conjunctivitis",
"drug": "calcitonin"
},
{
"ade": "rhinitis",
"drug": "Calsynar"
},
{
"ade": "perspiration",
"drug": "Calsynar"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).",
"role": "user"
},
{
"content": "[{'ade': 'rhinitis', 'drug': 'calcitonin'}, {'ade': 'perspiration', 'drug': 'calcitonin'}, {'ade': 'conjunctivitis', 'drug': 'Calsynar'}, {'ade': 'conjunctivitis', 'drug': 'calcitonin'}, {'ade': 'rhinitis', 'drug': 'Calsynar'}, {'ade': 'perspiration', 'drug': 'Calsynar'}]",
"role": "assistant"
}
] |
Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.
|
[
{
"ade": "fibrous myopathy",
"drug": "pentazocine"
},
{
"ade": "neuromuscular complication",
"drug": "pentazocine"
},
{
"ade": "pentazocine toxicity",
"drug": "pentazocine"
},
{
"ade": "neuropathy",
"drug": "pentazocine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.",
"role": "user"
},
{
"content": "[{'ade': 'fibrous myopathy', 'drug': 'pentazocine'}, {'ade': 'neuromuscular complication', 'drug': 'pentazocine'}, {'ade': 'pentazocine toxicity', 'drug': 'pentazocine'}, {'ade': 'neuropathy', 'drug': 'pentazocine'}]",
"role": "assistant"
}
] |
A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.
|
[
{
"ade": "severe splenic hemorrhage and rupture",
"drug": "tPA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.",
"role": "user"
},
{
"content": "[{'ade': 'severe splenic hemorrhage and rupture', 'drug': 'tPA'}]",
"role": "assistant"
}
] |
Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.
|
[
{
"ade": "interfere with tacrolimus metabolism",
"drug": "tacrolimus"
},
{
"ade": "interfere with tacrolimus metabolism",
"drug": "nefazodone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.",
"role": "user"
},
{
"content": "[{'ade': 'interfere with tacrolimus metabolism', 'drug': 'tacrolimus'}, {'ade': 'interfere with tacrolimus metabolism', 'drug': 'nefazodone'}]",
"role": "assistant"
}
] |
Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.
|
[
{
"ade": "dyspnea",
"drug": "verapamil"
},
{
"ade": "acute asthma",
"drug": "verapamil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.",
"role": "user"
},
{
"content": "[{'ade': 'dyspnea', 'drug': 'verapamil'}, {'ade': 'acute asthma', 'drug': 'verapamil'}]",
"role": "assistant"
}
] |
On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).
|
[
{
"ade": "pneumonitis",
"drug": "MTX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).",
"role": "user"
},
{
"content": "[{'ade': 'pneumonitis', 'drug': 'MTX'}]",
"role": "assistant"
}
] |
Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.
|
[
{
"ade": "bronchospasm",
"drug": "propranolol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.",
"role": "user"
},
{
"content": "[{'ade': 'bronchospasm', 'drug': 'propranolol'}]",
"role": "assistant"
}
] |
Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.
|
[
{
"ade": "hyperkalemia",
"drug": "ACTH"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.",
"role": "user"
},
{
"content": "[{'ade': 'hyperkalemia', 'drug': 'ACTH'}]",
"role": "assistant"
}
] |
A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.
|
[
{
"ade": "hepatic angiosarcoma",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.",
"role": "user"
},
{
"content": "[{'ade': 'hepatic angiosarcoma', 'drug': 'cyclophosphamide'}]",
"role": "assistant"
}
] |
Sustained monomorphic ventricular tachycardia after adenosine infusion.
|
[
{
"ade": "Sustained monomorphic ventricular tachycardia",
"drug": "adenosine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sustained monomorphic ventricular tachycardia after adenosine infusion.",
"role": "user"
},
{
"content": "[{'ade': 'Sustained monomorphic ventricular tachycardia', 'drug': 'adenosine'}]",
"role": "assistant"
}
] |
An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.
|
[
{
"ade": "leukoencephalopathy",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.",
"role": "user"
},
{
"content": "[{'ade': 'leukoencephalopathy', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.
|
[
{
"ade": "Alveolar-interstitial pneumopathy",
"drug": "gold"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.",
"role": "user"
},
{
"content": "[{'ade': 'Alveolar-interstitial pneumopathy', 'drug': 'gold'}]",
"role": "assistant"
}
] |
Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.
|
[
{
"ade": "Disseminated tuberculous lesions",
"drug": "BCG"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.",
"role": "user"
},
{
"content": "[{'ade': 'Disseminated tuberculous lesions', 'drug': 'BCG'}]",
"role": "assistant"
}
] |
The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.
|
[
{
"ade": "nephrotoxicity",
"drug": "mannitol"
},
{
"ade": "ARF",
"drug": "mannitol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.",
"role": "user"
},
{
"content": "[{'ade': 'nephrotoxicity', 'drug': 'mannitol'}, {'ade': 'ARF', 'drug': 'mannitol'}]",
"role": "assistant"
}
] |
Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.
|
[
{
"ade": "wide complex dysrhythmia",
"drug": "Propoxyphene"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.",
"role": "user"
},
{
"content": "[{'ade': 'wide complex dysrhythmia', 'drug': 'Propoxyphene'}]",
"role": "assistant"
}
] |
Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).
|
[
{
"ade": "CHF",
"drug": "IFN"
},
{
"ade": "congestive heart failure",
"drug": "IFN"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).",
"role": "user"
},
{
"content": "[{'ade': 'CHF', 'drug': 'IFN'}, {'ade': 'congestive heart failure', 'drug': 'IFN'}]",
"role": "assistant"
}
] |
We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.
|
[
{
"ade": "acute rhabdomyolysis",
"drug": "cerivastatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.",
"role": "user"
},
{
"content": "[{'ade': 'acute rhabdomyolysis', 'drug': 'cerivastatin'}]",
"role": "assistant"
}
] |
Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).
|
[
{
"ade": "fat embolism",
"drug": "Intralipid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).",
"role": "user"
},
{
"content": "[{'ade': 'fat embolism', 'drug': 'Intralipid'}]",
"role": "assistant"
}
] |
We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.
|
[
{
"ade": "leukopenia",
"drug": "AZA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.",
"role": "user"
},
{
"content": "[{'ade': 'leukopenia', 'drug': 'AZA'}]",
"role": "assistant"
}
] |
Acute renal failure during lisinopril and losartan therapy for proteinuria.
|
[
{
"ade": "Acute renal failure",
"drug": "losartan"
},
{
"ade": "Acute renal failure",
"drug": "lisinopril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute renal failure during lisinopril and losartan therapy for proteinuria.",
"role": "user"
},
{
"content": "[{'ade': 'Acute renal failure', 'drug': 'losartan'}, {'ade': 'Acute renal failure', 'drug': 'lisinopril'}]",
"role": "assistant"
}
] |
A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.
|
[
{
"ade": "severe hypersensitivity reaction",
"drug": "ibuprofen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.",
"role": "user"
},
{
"content": "[{'ade': 'severe hypersensitivity reaction', 'drug': 'ibuprofen'}]",
"role": "assistant"
}
] |
Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.
|
[
{
"ade": "acute hyponatraemia",
"drug": "indomethacin"
},
{
"ade": "acute hyponatraemia",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.",
"role": "user"
},
{
"content": "[{'ade': 'acute hyponatraemia', 'drug': 'indomethacin'}, {'ade': 'acute hyponatraemia', 'drug': 'cyclophosphamide'}]",
"role": "assistant"
}
] |
Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.
|
[
{
"ade": "Multifocal inflammatory leukoencephalopathy",
"drug": "levamisole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Multifocal inflammatory leukoencephalopathy', 'drug': 'levamisole'}]",
"role": "assistant"
}
] |
Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.
|
[
{
"ade": "myelotoxicity",
"drug": "6-mercaptopurine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.",
"role": "user"
},
{
"content": "[{'ade': 'myelotoxicity', 'drug': '6-mercaptopurine'}]",
"role": "assistant"
}
] |
A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.
|
[
{
"ade": "circulatory collapse",
"drug": "perospirone hydrochloride"
},
{
"ade": "deep coma",
"drug": "perospirone hydrochloride"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.",
"role": "user"
},
{
"content": "[{'ade': 'circulatory collapse', 'drug': 'perospirone hydrochloride'}, {'ade': 'deep coma', 'drug': 'perospirone hydrochloride'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.
|
[
{
"ade": "angle-closure glaucoma",
"drug": "Topiramate"
},
{
"ade": "anterior chamber shallowing",
"drug": "Topiramate"
},
{
"ade": "displacement of the lens-iris diaphragm",
"drug": "Topiramate"
},
{
"ade": "acute myopia",
"drug": "Topiramate"
},
{
"ade": "ciliochoroidal effusion",
"drug": "Topiramate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.",
"role": "user"
},
{
"content": "[{'ade': 'angle-closure glaucoma', 'drug': 'Topiramate'}, {'ade': 'anterior chamber shallowing', 'drug': 'Topiramate'}, {'ade': 'displacement of the lens-iris diaphragm', 'drug': 'Topiramate'}, {'ade': 'acute myopia', 'drug': 'Topiramate'}, {'ade': 'ciliochoroidal effusion', 'drug': 'Topiramate'}]",
"role": "assistant"
}
] |
An adult male presented with central blindness after ingesting methanol.
|
[
{
"ade": "central blindness",
"drug": "methanol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: An adult male presented with central blindness after ingesting methanol.",
"role": "user"
},
{
"content": "[{'ade': 'central blindness', 'drug': 'methanol'}]",
"role": "assistant"
}
] |
Their parkinsonism improved on discontinuation of metoclopramide therapy.
|
[
{
"ade": "parkinsonism",
"drug": "metoclopramide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Their parkinsonism improved on discontinuation of metoclopramide therapy.",
"role": "user"
},
{
"content": "[{'ade': 'parkinsonism', 'drug': 'metoclopramide'}]",
"role": "assistant"
}
] |
Delay of corneal wound healing in patients treated with colchicine.
|
[
{
"ade": "Delay of corneal wound healing",
"drug": "colchicine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Delay of corneal wound healing in patients treated with colchicine.",
"role": "user"
},
{
"content": "[{'ade': 'Delay of corneal wound healing', 'drug': 'colchicine'}]",
"role": "assistant"
}
] |
Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults.
|
[
{
"ade": "Cutaneous reactions",
"drug": "methimazole"
},
{
"ade": "Cutaneous reactions",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults.",
"role": "user"
},
{
"content": "[{'ade': 'Cutaneous reactions', 'drug': 'methimazole'}, {'ade': 'Cutaneous reactions', 'drug': 'propylthiouracil'}]",
"role": "assistant"
}
] |
To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.
|
[
{
"ade": "rhabdomyolysis",
"drug": "lovastatin"
},
{
"ade": "rhabdomyolysis",
"drug": "clarithromycin"
},
{
"ade": "rhabdomyolysis",
"drug": "azithromycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.",
"role": "user"
},
{
"content": "[{'ade': 'rhabdomyolysis', 'drug': 'lovastatin'}, {'ade': 'rhabdomyolysis', 'drug': 'clarithromycin'}, {'ade': 'rhabdomyolysis', 'drug': 'azithromycin'}]",
"role": "assistant"
}
] |
We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.
|
[
{
"ade": "acute bilateral parotitis",
"drug": "enalaprilat"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.",
"role": "user"
},
{
"content": "[{'ade': 'acute bilateral parotitis', 'drug': 'enalaprilat'}]",
"role": "assistant"
}
] |
CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.
|
[
{
"ade": "increase of INR",
"drug": "levamisole"
},
{
"ade": "increase of INR",
"drug": "5-FU"
},
{
"ade": "increase of INR",
"drug": "warfarin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.",
"role": "user"
},
{
"content": "[{'ade': 'increase of INR', 'drug': 'levamisole'}, {'ade': 'increase of INR', 'drug': '5-FU'}, {'ade': 'increase of INR', 'drug': 'warfarin'}]",
"role": "assistant"
}
] |
In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.
|
[
{
"ade": "blast crisis",
"drug": "imatinib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.",
"role": "user"
},
{
"content": "[{'ade': 'blast crisis', 'drug': 'imatinib'}]",
"role": "assistant"
}
] |
Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.
|
[
{
"ade": "hemorrhage",
"drug": "metformin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.",
"role": "user"
},
{
"content": "[{'ade': 'hemorrhage', 'drug': 'metformin'}]",
"role": "assistant"
}
] |
We describe a case of prolonged terbinafine-induced cholestatic liver disease.
|
[
{
"ade": "cholestatic liver disease",
"drug": "terbinafine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a case of prolonged terbinafine-induced cholestatic liver disease.",
"role": "user"
},
{
"content": "[{'ade': 'cholestatic liver disease', 'drug': 'terbinafine'}]",
"role": "assistant"
}
] |
A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease.
|
[
{
"ade": "chronic, watery diarrhea",
"drug": "lansoprazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease.",
"role": "user"
},
{
"content": "[{'ade': 'chronic, watery diarrhea', 'drug': 'lansoprazole'}]",
"role": "assistant"
}
] |
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.
|
[
{
"ade": "Gynecomastia",
"drug": "phenobarbital"
},
{
"ade": "Gynecomastia",
"drug": "fluoresone"
},
{
"ade": "Gynecomastia",
"drug": "phenytoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.",
"role": "user"
},
{
"content": "[{'ade': 'Gynecomastia', 'drug': 'phenobarbital'}, {'ade': 'Gynecomastia', 'drug': 'fluoresone'}, {'ade': 'Gynecomastia', 'drug': 'phenytoin'}]",
"role": "assistant"
}
] |
Acute coronary syndromes can be associated with the infusion of rituximab.
|
[
{
"ade": "Acute coronary syndromes",
"drug": "rituximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute coronary syndromes can be associated with the infusion of rituximab.",
"role": "user"
},
{
"content": "[{'ade': 'Acute coronary syndromes', 'drug': 'rituximab'}]",
"role": "assistant"
}
] |
In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.
|
[
{
"ade": "asterixis",
"drug": "CBZ"
},
{
"ade": "asterixis",
"drug": "carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.",
"role": "user"
},
{
"content": "[{'ade': 'asterixis', 'drug': 'CBZ'}, {'ade': 'asterixis', 'drug': 'carbamazepine'}]",
"role": "assistant"
}
] |
Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.
|
[
{
"ade": "Cardiomyopathy",
"drug": "adriamycin"
},
{
"ade": "Cardiomyopathy",
"drug": "mithramycin"
},
{
"ade": "Cardiomyopathy",
"drug": "actinomycin-D"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.",
"role": "user"
},
{
"content": "[{'ade': 'Cardiomyopathy', 'drug': 'adriamycin'}, {'ade': 'Cardiomyopathy', 'drug': 'mithramycin'}, {'ade': 'Cardiomyopathy', 'drug': 'actinomycin-D'}]",
"role": "assistant"
}
] |
Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.
|
[
{
"ade": "life-threatening vincristine neurotoxicity",
"drug": "vincristine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.",
"role": "user"
},
{
"content": "[{'ade': 'life-threatening vincristine neurotoxicity', 'drug': 'vincristine'}]",
"role": "assistant"
}
] |
Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction.
|
[
{
"ade": "Serotonin syndrome",
"drug": "metoclopramide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction.",
"role": "user"
},
{
"content": "[{'ade': 'Serotonin syndrome', 'drug': 'metoclopramide'}]",
"role": "assistant"
}
] |
Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.
|
[
{
"ade": "cutaneous skin eruptions",
"drug": "TMP-SMX"
},
{
"ade": "hypersensitivity syndrome",
"drug": "TMP-SMX"
},
{
"ade": "hepatotoxicity",
"drug": "TMP-SMX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.",
"role": "user"
},
{
"content": "[{'ade': 'cutaneous skin eruptions', 'drug': 'TMP-SMX'}, {'ade': 'hypersensitivity syndrome', 'drug': 'TMP-SMX'}, {'ade': 'hepatotoxicity', 'drug': 'TMP-SMX'}]",
"role": "assistant"
}
] |
Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.
|
[
{
"ade": "primary and secondary perforation of the bladder",
"drug": "epirubicin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.",
"role": "user"
},
{
"content": "[{'ade': 'primary and secondary perforation of the bladder', 'drug': 'epirubicin'}]",
"role": "assistant"
}
] |
After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.
|
[
{
"ade": "dyspnea",
"drug": "gemcitabine"
},
{
"ade": "dry cough",
"drug": "gemcitabine"
},
{
"ade": "subfebrile temperatures",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.",
"role": "user"
},
{
"content": "[{'ade': 'dyspnea', 'drug': 'gemcitabine'}, {'ade': 'dry cough', 'drug': 'gemcitabine'}, {'ade': 'subfebrile temperatures', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
Nonoliguric acute renal failure after captopril therapy.
|
[
{
"ade": "Nonoliguric acute renal failure",
"drug": "captopril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nonoliguric acute renal failure after captopril therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Nonoliguric acute renal failure', 'drug': 'captopril'}]",
"role": "assistant"
}
] |
RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated.
|
[
{
"ade": "RTA",
"drug": "FK506"
},
{
"ade": "nephrotoxicity",
"drug": "FK506"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated.",
"role": "user"
},
{
"content": "[{'ade': 'RTA', 'drug': 'FK506'}, {'ade': 'nephrotoxicity', 'drug': 'FK506'}]",
"role": "assistant"
}
] |
Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.
|
[
{
"ade": "C. difficile colitis",
"drug": "cisplatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.",
"role": "user"
},
{
"content": "[{'ade': 'C. difficile colitis', 'drug': 'cisplatin'}]",
"role": "assistant"
}
] |
With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion.
|
[
{
"ade": "leg pain",
"drug": "cyclosporine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion.",
"role": "user"
},
{
"content": "[{'ade': 'leg pain', 'drug': 'cyclosporine'}]",
"role": "assistant"
}
] |
Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.
|
[
{
"ade": "early chronic cardiomyopathy",
"drug": "anthracycline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.",
"role": "user"
},
{
"content": "[{'ade': 'early chronic cardiomyopathy', 'drug': 'anthracycline'}]",
"role": "assistant"
}
] |
Therefore, clinicians should pay close attention to possible onset of RD in patients with multiple risk factors for TD, even when SDA therapy is used.
|
[
{
"ade": "RD",
"drug": "SDA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Therefore, clinicians should pay close attention to possible onset of RD in patients with multiple risk factors for TD, even when SDA therapy is used.",
"role": "user"
},
{
"content": "[{'ade': 'RD', 'drug': 'SDA'}]",
"role": "assistant"
}
] |
Isoniazid associated, painful, bilateral gynaecomastia.
|
[
{
"ade": "bilateral gynaecomastia",
"drug": "Isoniazid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Isoniazid associated, painful, bilateral gynaecomastia.",
"role": "user"
},
{
"content": "[{'ade': 'bilateral gynaecomastia', 'drug': 'Isoniazid'}]",
"role": "assistant"
}
] |
Ciprofloxacin-induced psychosis.
|
[
{
"ade": "psychosis",
"drug": "Ciprofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ciprofloxacin-induced psychosis.",
"role": "user"
},
{
"content": "[{'ade': 'psychosis', 'drug': 'Ciprofloxacin'}]",
"role": "assistant"
}
] |
Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered.
|
[
{
"ade": "lost consciousness",
"drug": "prochlorperazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered.",
"role": "user"
},
{
"content": "[{'ade': 'lost consciousness', 'drug': 'prochlorperazine'}]",
"role": "assistant"
}
] |
Disulfiram-like reactions with newer cephalosporins: cefmenoxime.
|
[
{
"ade": "Disulfiram-like reactions",
"drug": "cefmenoxime"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Disulfiram-like reactions with newer cephalosporins: cefmenoxime.",
"role": "user"
},
{
"content": "[{'ade': 'Disulfiram-like reactions', 'drug': 'cefmenoxime'}]",
"role": "assistant"
}
] |
Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia.
|
[
{
"ade": "sustained ventricular tachycardia",
"drug": "thalidomide"
},
{
"ade": "Multiple syncopal episodes",
"drug": "thalidomide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia.",
"role": "user"
},
{
"content": "[{'ade': 'sustained ventricular tachycardia', 'drug': 'thalidomide'}, {'ade': 'Multiple syncopal episodes', 'drug': 'thalidomide'}]",
"role": "assistant"
}
] |
A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.
|
[
{
"ade": "exfoliative dermatitis",
"drug": "minocycline"
},
{
"ade": "eruption",
"drug": "minocycline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.",
"role": "user"
},
{
"content": "[{'ade': 'exfoliative dermatitis', 'drug': 'minocycline'}, {'ade': 'eruption', 'drug': 'minocycline'}]",
"role": "assistant"
}
] |
As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.
|
[
{
"ade": "diarrhoea",
"drug": "spironolactone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.",
"role": "user"
},
{
"content": "[{'ade': 'diarrhoea', 'drug': 'spironolactone'}]",
"role": "assistant"
}
] |
In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.
|
[
{
"ade": "ventricular tachycardia",
"drug": "bretylium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.",
"role": "user"
},
{
"content": "[{'ade': 'ventricular tachycardia', 'drug': 'bretylium'}]",
"role": "assistant"
}
] |
Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.
|
[
{
"ade": "pulmonary infiltrates with eosinophilia",
"drug": "Captopril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.",
"role": "user"
},
{
"content": "[{'ade': 'pulmonary infiltrates with eosinophilia', 'drug': 'Captopril'}]",
"role": "assistant"
}
] |
Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.
|
[
{
"ade": "psoriasiform eruptions",
"drug": "carbamazepine"
},
{
"ade": "psoriasiform eruptions",
"drug": "Sodium valproate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.",
"role": "user"
},
{
"content": "[{'ade': 'psoriasiform eruptions', 'drug': 'carbamazepine'}, {'ade': 'psoriasiform eruptions', 'drug': 'Sodium valproate'}]",
"role": "assistant"
}
] |
We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.
|
[
{
"ade": "seizure",
"drug": "L-asparaginase"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.",
"role": "user"
},
{
"content": "[{'ade': 'seizure', 'drug': 'L-asparaginase'}]",
"role": "assistant"
}
] |
Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.
|
[
{
"ade": "bilateral optic neuritis",
"drug": "recombinant interferon alpha-2b"
},
{
"ade": "bowel and bladder dysfunction",
"drug": "recombinant interferon alpha-2b"
},
{
"ade": "numbness of the lower extremities",
"drug": "recombinant interferon alpha-2b"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.",
"role": "user"
},
{
"content": "[{'ade': 'bilateral optic neuritis', 'drug': 'recombinant interferon alpha-2b'}, {'ade': 'bowel and bladder dysfunction', 'drug': 'recombinant interferon alpha-2b'}, {'ade': 'numbness of the lower extremities', 'drug': 'recombinant interferon alpha-2b'}]",
"role": "assistant"
}
] |
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.
|
[
{
"ade": "neurotoxicity",
"drug": "5-FU"
},
{
"ade": "cerebellar dysfunction",
"drug": "5-FU"
},
{
"ade": "neurotoxicity",
"drug": "5-fluorouracil"
},
{
"ade": "cerebellar dysfunction",
"drug": "5-fluorouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.",
"role": "user"
},
{
"content": "[{'ade': 'neurotoxicity', 'drug': '5-FU'}, {'ade': 'cerebellar dysfunction', 'drug': '5-FU'}, {'ade': 'neurotoxicity', 'drug': '5-fluorouracil'}, {'ade': 'cerebellar dysfunction', 'drug': '5-fluorouracil'}]",
"role": "assistant"
}
] |
Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.
|
[
{
"ade": "Masculinization of a female fetus",
"drug": "norethisterone"
},
{
"ade": "clitoral hypertrophy",
"drug": "norethisterone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.",
"role": "user"
},
{
"content": "[{'ade': 'Masculinization of a female fetus', 'drug': 'norethisterone'}, {'ade': 'clitoral hypertrophy', 'drug': 'norethisterone'}]",
"role": "assistant"
}
] |
A typical case of dextran-40 associated acute renal failure is presented.
|
[
{
"ade": "acute renal failure",
"drug": "dextran-40"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A typical case of dextran-40 associated acute renal failure is presented.",
"role": "user"
},
{
"content": "[{'ade': 'acute renal failure', 'drug': 'dextran-40'}]",
"role": "assistant"
}
] |
An unusual case of Ecstasy poisoning.
|
[
{
"ade": "Ecstasy poisoning",
"drug": "Ecstasy"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: An unusual case of Ecstasy poisoning.",
"role": "user"
},
{
"content": "[{'ade': 'Ecstasy poisoning', 'drug': 'Ecstasy'}]",
"role": "assistant"
}
] |
Persistent light reactivity from systemic quinine.
|
[
{
"ade": "Persistent light reactivity",
"drug": "quinine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Persistent light reactivity from systemic quinine.",
"role": "user"
},
{
"content": "[{'ade': 'Persistent light reactivity', 'drug': 'quinine'}]",
"role": "assistant"
}
] |
A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.
|
[
{
"ade": "hypersensitivity",
"drug": "allopurinol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity', 'drug': 'allopurinol'}]",
"role": "assistant"
}
] |
RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.
|
[
{
"ade": "sexual dysfunction",
"drug": "baclofen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.",
"role": "user"
},
{
"content": "[{'ade': 'sexual dysfunction', 'drug': 'baclofen'}]",
"role": "assistant"
}
] |
AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.
|
[
{
"ade": "celiac disease",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "celiac disease",
"drug": "ribavirin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.",
"role": "user"
},
{
"content": "[{'ade': 'celiac disease', 'drug': 'pegylated interferon alpha-2a'}, {'ade': 'celiac disease', 'drug': 'ribavirin'}]",
"role": "assistant"
}
] |
OBJECTIVE: To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis.
|
[
{
"ade": "hepatitis",
"drug": "itraconazole"
},
{
"ade": "acute cytolytic hepatitis",
"drug": "itraconazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis.",
"role": "user"
},
{
"content": "[{'ade': 'hepatitis', 'drug': 'itraconazole'}, {'ade': 'acute cytolytic hepatitis', 'drug': 'itraconazole'}]",
"role": "assistant"
}
] |
We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.
|
[
{
"ade": "acute hepatitis B and C",
"drug": "naltrexone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.",
"role": "user"
},
{
"content": "[{'ade': 'acute hepatitis B and C', 'drug': 'naltrexone'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.
|
[
{
"ade": "carotid insufficiency",
"drug": "bevacizumab"
},
{
"ade": "coagulopathy",
"drug": "bevacizumab"
},
{
"ade": "poorly controlled diabetes mellitus",
"drug": "bevacizumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.",
"role": "user"
},
{
"content": "[{'ade': 'carotid insufficiency', 'drug': 'bevacizumab'}, {'ade': 'coagulopathy', 'drug': 'bevacizumab'}, {'ade': 'poorly controlled diabetes mellitus', 'drug': 'bevacizumab'}]",
"role": "assistant"
}
] |
Cardiorespiratory toxicity due to miconazole.
|
[
{
"ade": "Cardiorespiratory toxicity",
"drug": "miconazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cardiorespiratory toxicity due to miconazole.",
"role": "user"
},
{
"content": "[{'ade': 'Cardiorespiratory toxicity', 'drug': 'miconazole'}]",
"role": "assistant"
}
] |
His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.
|
[
{
"ade": "impaired memory",
"drug": "atenolol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.",
"role": "user"
},
{
"content": "[{'ade': 'impaired memory', 'drug': 'atenolol'}]",
"role": "assistant"
}
] |
There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.
|
[
{
"ade": "ocular toxicity",
"drug": "ethambutol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.",
"role": "user"
},
{
"content": "[{'ade': 'ocular toxicity', 'drug': 'ethambutol'}]",
"role": "assistant"
}
] |
Acute sensorineural hearing loss following intravenous ketoralac administration.
|
[
{
"ade": "Acute sensorineural hearing loss",
"drug": "ketoralac"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute sensorineural hearing loss following intravenous ketoralac administration.",
"role": "user"
},
{
"content": "[{'ade': 'Acute sensorineural hearing loss', 'drug': 'ketoralac'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.
|
[
{
"ade": "neurologic symptoms",
"drug": "vancomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.",
"role": "user"
},
{
"content": "[{'ade': 'neurologic symptoms', 'drug': 'vancomycin'}]",
"role": "assistant"
}
] |
A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.
|
[
{
"ade": "trichiasis",
"drug": "prostaglandin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.",
"role": "user"
},
{
"content": "[{'ade': 'trichiasis', 'drug': 'prostaglandin'}]",
"role": "assistant"
}
] |
Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.
|
[
{
"ade": "Fulminant hepatitis",
"drug": "didanosine"
},
{
"ade": "severe lactate acidosis",
"drug": "didanosine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Fulminant hepatitis', 'drug': 'didanosine'}, {'ade': 'severe lactate acidosis', 'drug': 'didanosine'}]",
"role": "assistant"
}
] |
Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.
|
[
{
"ade": "hair loss",
"drug": "paroxetine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.",
"role": "user"
},
{
"content": "[{'ade': 'hair loss', 'drug': 'paroxetine'}]",
"role": "assistant"
}
] |
RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.
|
[
{
"ade": "visual field defects",
"drug": "triamcinolone"
},
{
"ade": "severe vision loss",
"drug": "triamcinolone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.",
"role": "user"
},
{
"content": "[{'ade': 'visual field defects', 'drug': 'triamcinolone'}, {'ade': 'severe vision loss', 'drug': 'triamcinolone'}]",
"role": "assistant"
}
] |
INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.
|
[
{
"ade": "Cardiac complications",
"drug": "amphotericin B"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.",
"role": "user"
},
{
"content": "[{'ade': 'Cardiac complications', 'drug': 'amphotericin B'}]",
"role": "assistant"
}
] |
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