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Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.	[ { "ade": "diabetes insipidus", "drug": "lithium" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfull...
Mental nerve neuropathy as a result of hepatitis B vaccination.	[ { "ade": "Mental nerve neuropathy", "drug": "hepatitis B vaccination" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Mental nerve neuropathy as a result of hepatitis B vaccination.", "role": "user" }, { "content": "[{'ade': 'Mental nerv...
Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.	[ { "ade": "severe hypersensitivity", "drug": "carboplatin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had ...
Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).	[ { "ade": "diabetes", "drug": "indapamide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).", "role": "user" }, {...
The role of Adriamycin in the production of cardiotoxicity is reviewed.	[ { "ade": "cardiotoxicity", "drug": "Adriamycin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The role of Adriamycin in the production of cardiotoxicity is reviewed.", "role": "user" }, { "content": "[{'ade': 'car...
Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.	[ { "ade": "Growth and adrenal suppression", "drug": "fluticasone propionate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.", "role": "user" }, { ...
Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.	[ { "ade": "hypoadrenalism", "drug": "o,p'-DDD" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.", "role": "...
A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.	[ { "ade": "myoclonus", "drug": "methadone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.", "role": "user" }, { ...
In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.	[ { "ade": "severe systemic CMV infection", "drug": "cyclosporine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with...
OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).	[ { "ade": "myopathy", "drug": "colchicine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).", "role": "us...
Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.	[ { "ade": "SJS", "drug": "nevirapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nev...
The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.	[ { "ade": "fungal infections", "drug": "alemtuzumab" }, { "ade": "opportunistic infections", "drug": "alemtuzumab" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular at...
It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.	[ { "ade": "cerebral atrophy", "drug": "ACTH" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with...
To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.	[ { "ade": "irreversible renal failure", "drug": "TDF" }, { "ade": "rickets", "drug": "TDF" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric pat...
Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.	[ { "ade": "acute intermittent porphyria", "drug": "Diphenylhydantoin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.",...
We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).	[ { "ade": "rhinitis", "drug": "calcitonin" }, { "ade": "perspiration", "drug": "calcitonin" }, { "ade": "conjunctivitis", "drug": "Calsynar" }, { "ade": "conjunctivitis", "drug": "calcitonin" }, { "ade": "rhinitis", "drug": "Calsynar" }, { "ade": "persp...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediat...
Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.	[ { "ade": "fibrous myopathy", "drug": "pentazocine" }, { "ade": "neuromuscular complication", "drug": "pentazocine" }, { "ade": "pentazocine toxicity", "drug": "pentazocine" }, { "ade": "neuropathy", "drug": "pentazocine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to p...
A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.	[ { "ade": "severe splenic hemorrhage and rupture", "drug": "tPA" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acu...
Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.	[ { "ade": "interfere with tacrolimus metabolism", "drug": "tacrolimus" }, { "ade": "interfere with tacrolimus metabolism", "drug": "nefazodone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, shoul...
Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.	[ { "ade": "dyspnea", "drug": "verapamil" }, { "ade": "acute asthma", "drug": "verapamil" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic as...
On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).	[ { "ade": "pneumonitis", "drug": "MTX" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).", "role": "user" }, { "c...
Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.	[ { "ade": "bronchospasm", "drug": "propranolol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.", "role":...
Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.	[ { "ade": "hyperkalemia", "drug": "ACTH" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.", "role": "user" }...
A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.	[ { "ade": "hepatic angiosarcoma", "drug": "cyclophosphamide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment....
Sustained monomorphic ventricular tachycardia after adenosine infusion.	[ { "ade": "Sustained monomorphic ventricular tachycardia", "drug": "adenosine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sustained monomorphic ventricular tachycardia after adenosine infusion.", "role": "user" }, { "content": "[{'ade': 'Sus...
An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.	[ { "ade": "leukoencephalopathy", "drug": "methotrexate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medullob...
Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.	[ { "ade": "Alveolar-interstitial pneumopathy", "drug": "gold" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.", "role": "user"...
Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.	[ { "ade": "Disseminated tuberculous lesions", "drug": "BCG" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.", "role"...
The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.	[ { "ade": "nephrotoxicity", "drug": "mannitol" }, { "ade": "ARF", "drug": "mannitol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not r...
Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.	[ { "ade": "wide complex dysrhythmia", "drug": "Propoxyphene" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the lite...
Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).	[ { "ade": "CHF", "drug": "IFN" }, { "ade": "congestive heart failure", "drug": "IFN" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).", "ro...
We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.	[ { "ade": "acute rhabdomyolysis", "drug": "cerivastatin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.", "role": "user" }, { "content": "...
Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).	[ { "ade": "fat embolism", "drug": "Intralipid" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).", "role":...
We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.	[ { "ade": "leukopenia", "drug": "AZA" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy...
Acute renal failure during lisinopril and losartan therapy for proteinuria.	[ { "ade": "Acute renal failure", "drug": "losartan" }, { "ade": "Acute renal failure", "drug": "lisinopril" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute renal failure during lisinopril and losartan therapy for proteinuria.", "role": "user" }, { "content": "[{'ade': ...
A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.	[ { "ade": "severe hypersensitivity reaction", "drug": "ibuprofen" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.", "role": "...
Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.	[ { "ade": "acute hyponatraemia", "drug": "indomethacin" }, { "ade": "acute hyponatraemia", "drug": "cyclophosphamide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.", "role": "user" }, { "cont...
Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.	[ { "ade": "Multifocal inflammatory leukoencephalopathy", "drug": "levamisole" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.", "role": "user" }, { "content": "[{'ad...
Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.	[ { "ade": "myelotoxicity", "drug": "6-mercaptopurine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemi...
A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.	[ { "ade": "circulatory collapse", "drug": "perospirone hydrochloride" }, { "ade": "deep coma", "drug": "perospirone hydrochloride" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days ...