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Hepatobiliary disorders associated with orally administered terbinafine have rarely been reported.	[ { "ade": "Hepatobiliary disorders", "drug": "terbinafine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatobiliary disorders associated with orally administered terbinafine have rarely been reported.", "role": "user" }, { ...
Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.	[ { "ade": "mild hepatotoxicity", "drug": "nevirapine" }, { "ade": "Severe leukopenia", "drug": "nevirapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.", "role": "user" }, { ...
PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.	[ { "ade": "decreased vision", "drug": "rifabutin" }, { "ade": "retinal damage", "drug": "rifabutin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal da...
To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration.	[ { "ade": "isolated paresthesia", "drug": "sulindac" }, { "ade": "peripheral neuropathy", "drug": "sulindac" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involveme...
Anaphylactic reaction to recombinant insulin-like growth factor-I.	[ { "ade": "Anaphylactic reaction", "drug": "recombinant insulin-like growth factor-I" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Anaphylactic reaction to recombinant insulin-like growth factor-I.", "role": "user" }, { "content": "[{'ade': 'Anaphyla...
Chromosome abnormalities after chlorambucil therapy of polycythaemia vera.	[ { "ade": "Chromosome abnormalities", "drug": "chlorambucil" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Chromosome abnormalities after chlorambucil therapy of polycythaemia vera.", "role": "user" }, { "content": "[{'ade': '...
METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.	[ { "ade": "pseudoporphyria", "drug": "oxaprozin" }, { "ade": "pseudoporphyria", "drug": "naproxen" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.", "role": "user" }, { "content": "[{'...
Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia.	[ { "ade": "Philadelphia positive chronic myeloid leukaemia", "drug": "hydroxyurea" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential ...
We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.	[ { "ade": "ileus", "drug": "nimodipine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimod...
The authors report the first case of bucillamine-induced giant mammary hyperplasia.	[ { "ade": "giant mammary hyperplasia", "drug": "bucillamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors report the first case of bucillamine-induced giant mammary hyperplasia.", "role": "user" }, { "content": "[...
These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.	[ { "ade": "intrahepatic cholestasis", "drug": "chlorpropamide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur w...
A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery.	[ { "ade": "anaphylactoid reaction", "drug": "Gelofusine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, ...
Acute dystonic reaction with low-dose pimozide.	[ { "ade": "Acute dystonic reaction", "drug": "pimozide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute dystonic reaction with low-dose pimozide.", "role": "user" }, { "content": "[{'ade': 'Acute dystonic reaction', '...
Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.	[ { "ade": "Dyspnea", "drug": "rituximab" }, { "ade": "pleuritic chest pain", "drug": "rituximab" }, { "ade": "hypoxemia", "drug": "rituximab" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent ...
Leflunomide-associated infections in rheumatoid arthritis.	[ { "ade": "infections", "drug": "Leflunomide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Leflunomide-associated infections in rheumatoid arthritis.", "role": "user" }, { "content": "[{'ade': 'infections', 'dr...
We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.	[ { "ade": "myelotoxicity", "drug": "chloramphenicol" }, { "ade": "dyserythropoietic anaemia", "drug": "linezolid" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to c...
We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL), presenting with right-sided paralysis and aphasia after second consolidation with intrathecal triple-drug therapy gi...	[ { "ade": "sub-acute leukoencephalopathy", "drug": "methotrexate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-ye...
Aminophylline hypersensitivity apparently due to ethylenediamine.	[ { "ade": "Aminophylline hypersensitivity", "drug": "Aminophylline" }, { "ade": "Aminophylline hypersensitivity", "drug": "ethylenediamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Aminophylline hypersensitivity apparently due to ethylenediamine.", "role": "user" }, { "content": "[{'ade': 'Aminophyl...
We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.	[ { "ade": "seizures", "drug": "clozapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.", "role": "user" }, {...
The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.	[ { "ade": "hypersensitivity reaction", "drug": "pranlukast" }, { "ade": "ATIN", "drug": "pranlukast" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing ...
Transfusion haemosiderosis inspite of regular use of desferrioxamine: case report.	[ { "ade": "Transfusion haemosiderosis", "drug": "desferrioxamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Transfusion haemosiderosis inspite of regular use of desferrioxamine: case report.", "role": "user" }, { "content": "[{...
In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.	[ { "ade": "thrombocytopenia", "drug": "mitomycin C" }, { "ade": "progressive renal failure", "drug": "MMC" }, { "ade": "hemolytic anemia", "drug": "mitomycin C" }, { "ade": "thrombocytopenia", "drug": "MMC" }, { "ade": "hemolytic uremic syndrome", "drug": "mito...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia,...
Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.	[ { "ade": "Nephrotic syndrome", "drug": "interferon-beta-1b" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.", "role": "user" }, { "content": ...
However, to our knowledge, in newborns there have been no reported cases to date of thrombocytosis induced by enoxaparin.	[ { "ade": "thrombocytosis", "drug": "enoxaparin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, to our knowledge, in newborns there have been no reported cases to date of thrombocytosis induced by enoxaparin.", "ro...
CASE SUMMARY: A 57-year-old female with cardiomyopathy and "sulfa" (trimethoprim/sulfamethoxazole) allergy documented as pancreatitis presented with symptoms consistent with pancreatitis after use of furosemide.	[ { "ade": "pancreatitis", "drug": "furosemide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CASE SUMMARY: A 57-year-old female with cardiomyopathy and \"sulfa\" (trimethoprim/sulfamethoxazole) allergy documented as pancreat...
A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.	[ { "ade": "lupus-like syndrome", "drug": "methotrexate" }, { "ade": "lupus-like syndrome", "drug": "infliximab" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotre...
Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.	[ { "ade": "Hepatocellular damage", "drug": "iron sucrose" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.", "role": "user" }, { "conten...
We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.	[ { "ade": "nephrotoxicity", "drug": "TDF" }, { "ade": "nephrotoxicity", "drug": "tenofovir" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.", "role": "user" },...
Optic neuropathy in ethambutol-treated renal tuberculosis.	[ { "ade": "Optic neuropathy", "drug": "ethambutol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Optic neuropathy in ethambutol-treated renal tuberculosis.", "role": "user" }, { "content": "[{'ade': 'Optic neuropathy...
The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously.	[ { "ade": "visual field loss", "drug": "vigabatrin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed vi...
INH, which is a leading cause of drug eruptions in the above group of drugs was withdrawn.	[ { "ade": "drug eruptions", "drug": "INH" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: INH, which is a leading cause of drug eruptions in the above group of drugs was withdrawn.", "role": "user" }, { "conte...
Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.	[ { "ade": "peripheral vasculopathy", "drug": "Methylphenidate" }, { "ade": "peripheral vasculopathy", "drug": "dextroamphetamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.", "role": "user" }, { "content": "[{'ade': 'peri...
We herein report this rare case of acute onset of nephrotic syndrome during interferon-alpha retreatment.	[ { "ade": "nephrotic syndrome", "drug": "interferon-alpha" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We herein report this rare case of acute onset of nephrotic syndrome during interferon-alpha retreatment.", "role": "user" },...
Primary cutaneous coccidioidomycosis and subsequent drug eruption to itraconazole in a dog.	[ { "ade": "Primary cutaneous coccidioidomycosis", "drug": "itraconazole" }, { "ade": "drug eruption", "drug": "itraconazole" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Primary cutaneous coccidioidomycosis and subsequent drug eruption to itraconazole in a dog.", "role": "user" }, { "cont...
Acute esmolol toxicity may be self-limiting because of its extremely short half-life.	[ { "ade": "esmolol toxicity", "drug": "esmolol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute esmolol toxicity may be self-limiting because of its extremely short half-life.", "role": "user" }, { "content": ...
We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency.	[ { "ade": "life-threatening complications", "drug": "5-FU" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was...
It is likely that RA contributed to the deterioration in renal function in these patients.	[ { "ade": "deterioration in renal function", "drug": "RA" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is likely that RA contributed to the deterioration in renal function in these patients.", "role": "user" }, { "conte...
Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.	[ { "ade": "Myoglobinuria", "drug": "vasopressin" }, { "ade": "acute renal failure", "drug": "vasopressin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.", "ro...
Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.	[ { "ade": "contact dermatitis", "drug": "sodium bisulfite" }, { "ade": "eruption", "drug": "sodium bisulfite" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.", "role": "user" }, { "content": "[...
A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.	[ { "ade": "one patient became unconscious", "drug": "cotrimoxazole" }, { "ade": "hyperkalaemia", "drug": "cotrimoxazole" }, { "ade": "increased urinary N-acetyl glucosaminase", "drug": "cotrimoxazole" }, { "ade": "elevation of serum creatinine and blood urea", "drug": "cot...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-a...