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Hepatobiliary disorders associated with orally administered terbinafine have rarely been reported.
|
[
{
"ade": "Hepatobiliary disorders",
"drug": "terbinafine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatobiliary disorders associated with orally administered terbinafine have rarely been reported.",
"role": "user"
},
{
"content": "[{'ade': 'Hepatobiliary disorders', 'drug': 'terbinafine'}]",
"role": "assistant"
}
] |
Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.
|
[
{
"ade": "mild hepatotoxicity",
"drug": "nevirapine"
},
{
"ade": "Severe leukopenia",
"drug": "nevirapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.",
"role": "user"
},
{
"content": "[{'ade': 'mild hepatotoxicity', 'drug': 'nevirapine'}, {'ade': 'Severe leukopenia', 'drug': 'nevirapine'}]",
"role": "assistant"
}
] |
PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.
|
[
{
"ade": "decreased vision",
"drug": "rifabutin"
},
{
"ade": "retinal damage",
"drug": "rifabutin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.",
"role": "user"
},
{
"content": "[{'ade': 'decreased vision', 'drug': 'rifabutin'}, {'ade': 'retinal damage', 'drug': 'rifabutin'}]",
"role": "assistant"
}
] |
To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration.
|
[
{
"ade": "isolated paresthesia",
"drug": "sulindac"
},
{
"ade": "peripheral neuropathy",
"drug": "sulindac"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration.",
"role": "user"
},
{
"content": "[{'ade': 'isolated paresthesia', 'drug': 'sulindac'}, {'ade': 'peripheral neuropathy', 'drug': 'sulindac'}]",
"role": "assistant"
}
] |
Anaphylactic reaction to recombinant insulin-like growth factor-I.
|
[
{
"ade": "Anaphylactic reaction",
"drug": "recombinant insulin-like growth factor-I"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Anaphylactic reaction to recombinant insulin-like growth factor-I.",
"role": "user"
},
{
"content": "[{'ade': 'Anaphylactic reaction', 'drug': 'recombinant insulin-like growth factor-I'}]",
"role": "assistant"
}
] |
Chromosome abnormalities after chlorambucil therapy of polycythaemia vera.
|
[
{
"ade": "Chromosome abnormalities",
"drug": "chlorambucil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Chromosome abnormalities after chlorambucil therapy of polycythaemia vera.",
"role": "user"
},
{
"content": "[{'ade': 'Chromosome abnormalities', 'drug': 'chlorambucil'}]",
"role": "assistant"
}
] |
METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.
|
[
{
"ade": "pseudoporphyria",
"drug": "oxaprozin"
},
{
"ade": "pseudoporphyria",
"drug": "naproxen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.",
"role": "user"
},
{
"content": "[{'ade': 'pseudoporphyria', 'drug': 'oxaprozin'}, {'ade': 'pseudoporphyria', 'drug': 'naproxen'}]",
"role": "assistant"
}
] |
Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia.
|
[
{
"ade": "Philadelphia positive chronic myeloid leukaemia",
"drug": "hydroxyurea"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia.",
"role": "user"
},
{
"content": "[{'ade': 'Philadelphia positive chronic myeloid leukaemia', 'drug': 'hydroxyurea'}]",
"role": "assistant"
}
] |
We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.
|
[
{
"ade": "ileus",
"drug": "nimodipine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.",
"role": "user"
},
{
"content": "[{'ade': 'ileus', 'drug': 'nimodipine'}]",
"role": "assistant"
}
] |
The authors report the first case of bucillamine-induced giant mammary hyperplasia.
|
[
{
"ade": "giant mammary hyperplasia",
"drug": "bucillamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors report the first case of bucillamine-induced giant mammary hyperplasia.",
"role": "user"
},
{
"content": "[{'ade': 'giant mammary hyperplasia', 'drug': 'bucillamine'}]",
"role": "assistant"
}
] |
These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.
|
[
{
"ade": "intrahepatic cholestasis",
"drug": "chlorpropamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.",
"role": "user"
},
{
"content": "[{'ade': 'intrahepatic cholestasis', 'drug': 'chlorpropamide'}]",
"role": "assistant"
}
] |
A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery.
|
[
{
"ade": "anaphylactoid reaction",
"drug": "Gelofusine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery.",
"role": "user"
},
{
"content": "[{'ade': 'anaphylactoid reaction', 'drug': 'Gelofusine'}]",
"role": "assistant"
}
] |
Acute dystonic reaction with low-dose pimozide.
|
[
{
"ade": "Acute dystonic reaction",
"drug": "pimozide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute dystonic reaction with low-dose pimozide.",
"role": "user"
},
{
"content": "[{'ade': 'Acute dystonic reaction', 'drug': 'pimozide'}]",
"role": "assistant"
}
] |
Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.
|
[
{
"ade": "Dyspnea",
"drug": "rituximab"
},
{
"ade": "pleuritic chest pain",
"drug": "rituximab"
},
{
"ade": "hypoxemia",
"drug": "rituximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.",
"role": "user"
},
{
"content": "[{'ade': 'Dyspnea', 'drug': 'rituximab'}, {'ade': 'pleuritic chest pain', 'drug': 'rituximab'}, {'ade': 'hypoxemia', 'drug': 'rituximab'}]",
"role": "assistant"
}
] |
Leflunomide-associated infections in rheumatoid arthritis.
|
[
{
"ade": "infections",
"drug": "Leflunomide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Leflunomide-associated infections in rheumatoid arthritis.",
"role": "user"
},
{
"content": "[{'ade': 'infections', 'drug': 'Leflunomide'}]",
"role": "assistant"
}
] |
We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.
|
[
{
"ade": "myelotoxicity",
"drug": "chloramphenicol"
},
{
"ade": "dyserythropoietic anaemia",
"drug": "linezolid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.",
"role": "user"
},
{
"content": "[{'ade': 'myelotoxicity', 'drug': 'chloramphenicol'}, {'ade': 'dyserythropoietic anaemia', 'drug': 'linezolid'}]",
"role": "assistant"
}
] |
We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL), presenting with right-sided paralysis and aphasia after second consolidation with intrathecal triple-drug therapy given intrathecally.
|
[
{
"ade": "sub-acute leukoencephalopathy",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL), presenting with right-sided paralysis and aphasia after second consolidation with intrathecal triple-drug therapy given intrathecally.",
"role": "user"
},
{
"content": "[{'ade': 'sub-acute leukoencephalopathy', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Aminophylline hypersensitivity apparently due to ethylenediamine.
|
[
{
"ade": "Aminophylline hypersensitivity",
"drug": "Aminophylline"
},
{
"ade": "Aminophylline hypersensitivity",
"drug": "ethylenediamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Aminophylline hypersensitivity apparently due to ethylenediamine.",
"role": "user"
},
{
"content": "[{'ade': 'Aminophylline hypersensitivity', 'drug': 'Aminophylline'}, {'ade': 'Aminophylline hypersensitivity', 'drug': 'ethylenediamine'}]",
"role": "assistant"
}
] |
We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.
|
[
{
"ade": "seizures",
"drug": "clozapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.",
"role": "user"
},
{
"content": "[{'ade': 'seizures', 'drug': 'clozapine'}]",
"role": "assistant"
}
] |
The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.
|
[
{
"ade": "hypersensitivity reaction",
"drug": "pranlukast"
},
{
"ade": "ATIN",
"drug": "pranlukast"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity reaction', 'drug': 'pranlukast'}, {'ade': 'ATIN', 'drug': 'pranlukast'}]",
"role": "assistant"
}
] |
Transfusion haemosiderosis inspite of regular use of desferrioxamine: case report.
|
[
{
"ade": "Transfusion haemosiderosis",
"drug": "desferrioxamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Transfusion haemosiderosis inspite of regular use of desferrioxamine: case report.",
"role": "user"
},
{
"content": "[{'ade': 'Transfusion haemosiderosis', 'drug': 'desferrioxamine'}]",
"role": "assistant"
}
] |
In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.
|
[
{
"ade": "thrombocytopenia",
"drug": "mitomycin C"
},
{
"ade": "progressive renal failure",
"drug": "MMC"
},
{
"ade": "hemolytic anemia",
"drug": "mitomycin C"
},
{
"ade": "thrombocytopenia",
"drug": "MMC"
},
{
"ade": "hemolytic uremic syndrome",
"drug": "mitomycin C"
},
{
"ade": "hemolytic anemia",
"drug": "MMC"
},
{
"ade": "progressive renal failure",
"drug": "mitomycin C"
},
{
"ade": "hemolytic uremic syndrome",
"drug": "MMC"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'mitomycin C'}, {'ade': 'progressive renal failure', 'drug': 'MMC'}, {'ade': 'hemolytic anemia', 'drug': 'mitomycin C'}, {'ade': 'thrombocytopenia', 'drug': 'MMC'}, {'ade': 'hemolytic uremic syndrome', 'drug': 'mitomycin C'}, {'ade': 'hemolytic anemia', 'drug': 'MMC'}, {'ade': 'progressive renal failure', 'drug': 'mitomycin C'}, {'ade': 'hemolytic uremic syndrome', 'drug': 'MMC'}]",
"role": "assistant"
}
] |
Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.
|
[
{
"ade": "Nephrotic syndrome",
"drug": "interferon-beta-1b"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.",
"role": "user"
},
{
"content": "[{'ade': 'Nephrotic syndrome', 'drug': 'interferon-beta-1b'}]",
"role": "assistant"
}
] |
However, to our knowledge, in newborns there have been no reported cases to date of thrombocytosis induced by enoxaparin.
|
[
{
"ade": "thrombocytosis",
"drug": "enoxaparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, to our knowledge, in newborns there have been no reported cases to date of thrombocytosis induced by enoxaparin.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytosis', 'drug': 'enoxaparin'}]",
"role": "assistant"
}
] |
CASE SUMMARY: A 57-year-old female with cardiomyopathy and "sulfa" (trimethoprim/sulfamethoxazole) allergy documented as pancreatitis presented with symptoms consistent with pancreatitis after use of furosemide.
|
[
{
"ade": "pancreatitis",
"drug": "furosemide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CASE SUMMARY: A 57-year-old female with cardiomyopathy and \"sulfa\" (trimethoprim/sulfamethoxazole) allergy documented as pancreatitis presented with symptoms consistent with pancreatitis after use of furosemide.",
"role": "user"
},
{
"content": "[{'ade': 'pancreatitis', 'drug': 'furosemide'}]",
"role": "assistant"
}
] |
A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.
|
[
{
"ade": "lupus-like syndrome",
"drug": "methotrexate"
},
{
"ade": "lupus-like syndrome",
"drug": "infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.",
"role": "user"
},
{
"content": "[{'ade': 'lupus-like syndrome', 'drug': 'methotrexate'}, {'ade': 'lupus-like syndrome', 'drug': 'infliximab'}]",
"role": "assistant"
}
] |
Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.
|
[
{
"ade": "Hepatocellular damage",
"drug": "iron sucrose"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.",
"role": "user"
},
{
"content": "[{'ade': 'Hepatocellular damage', 'drug': 'iron sucrose'}]",
"role": "assistant"
}
] |
We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.
|
[
{
"ade": "nephrotoxicity",
"drug": "TDF"
},
{
"ade": "nephrotoxicity",
"drug": "tenofovir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.",
"role": "user"
},
{
"content": "[{'ade': 'nephrotoxicity', 'drug': 'TDF'}, {'ade': 'nephrotoxicity', 'drug': 'tenofovir'}]",
"role": "assistant"
}
] |
Optic neuropathy in ethambutol-treated renal tuberculosis.
|
[
{
"ade": "Optic neuropathy",
"drug": "ethambutol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Optic neuropathy in ethambutol-treated renal tuberculosis.",
"role": "user"
},
{
"content": "[{'ade': 'Optic neuropathy', 'drug': 'ethambutol'}]",
"role": "assistant"
}
] |
The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously.
|
[
{
"ade": "visual field loss",
"drug": "vigabatrin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously.",
"role": "user"
},
{
"content": "[{'ade': 'visual field loss', 'drug': 'vigabatrin'}]",
"role": "assistant"
}
] |
INH, which is a leading cause of drug eruptions in the above group of drugs was withdrawn.
|
[
{
"ade": "drug eruptions",
"drug": "INH"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: INH, which is a leading cause of drug eruptions in the above group of drugs was withdrawn.",
"role": "user"
},
{
"content": "[{'ade': 'drug eruptions', 'drug': 'INH'}]",
"role": "assistant"
}
] |
Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.
|
[
{
"ade": "peripheral vasculopathy",
"drug": "Methylphenidate"
},
{
"ade": "peripheral vasculopathy",
"drug": "dextroamphetamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.",
"role": "user"
},
{
"content": "[{'ade': 'peripheral vasculopathy', 'drug': 'Methylphenidate'}, {'ade': 'peripheral vasculopathy', 'drug': 'dextroamphetamine'}]",
"role": "assistant"
}
] |
We herein report this rare case of acute onset of nephrotic syndrome during interferon-alpha retreatment.
|
[
{
"ade": "nephrotic syndrome",
"drug": "interferon-alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We herein report this rare case of acute onset of nephrotic syndrome during interferon-alpha retreatment.",
"role": "user"
},
{
"content": "[{'ade': 'nephrotic syndrome', 'drug': 'interferon-alpha'}]",
"role": "assistant"
}
] |
Primary cutaneous coccidioidomycosis and subsequent drug eruption to itraconazole in a dog.
|
[
{
"ade": "Primary cutaneous coccidioidomycosis",
"drug": "itraconazole"
},
{
"ade": "drug eruption",
"drug": "itraconazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Primary cutaneous coccidioidomycosis and subsequent drug eruption to itraconazole in a dog.",
"role": "user"
},
{
"content": "[{'ade': 'Primary cutaneous coccidioidomycosis', 'drug': 'itraconazole'}, {'ade': 'drug eruption', 'drug': 'itraconazole'}]",
"role": "assistant"
}
] |
Acute esmolol toxicity may be self-limiting because of its extremely short half-life.
|
[
{
"ade": "esmolol toxicity",
"drug": "esmolol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute esmolol toxicity may be self-limiting because of its extremely short half-life.",
"role": "user"
},
{
"content": "[{'ade': 'esmolol toxicity', 'drug': 'esmolol'}]",
"role": "assistant"
}
] |
We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency.
|
[
{
"ade": "life-threatening complications",
"drug": "5-FU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency.",
"role": "user"
},
{
"content": "[{'ade': 'life-threatening complications', 'drug': '5-FU'}]",
"role": "assistant"
}
] |
It is likely that RA contributed to the deterioration in renal function in these patients.
|
[
{
"ade": "deterioration in renal function",
"drug": "RA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is likely that RA contributed to the deterioration in renal function in these patients.",
"role": "user"
},
{
"content": "[{'ade': 'deterioration in renal function', 'drug': 'RA'}]",
"role": "assistant"
}
] |
Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.
|
[
{
"ade": "Myoglobinuria",
"drug": "vasopressin"
},
{
"ade": "acute renal failure",
"drug": "vasopressin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.",
"role": "user"
},
{
"content": "[{'ade': 'Myoglobinuria', 'drug': 'vasopressin'}, {'ade': 'acute renal failure', 'drug': 'vasopressin'}]",
"role": "assistant"
}
] |
Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.
|
[
{
"ade": "contact dermatitis",
"drug": "sodium bisulfite"
},
{
"ade": "eruption",
"drug": "sodium bisulfite"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.",
"role": "user"
},
{
"content": "[{'ade': 'contact dermatitis', 'drug': 'sodium bisulfite'}, {'ade': 'eruption', 'drug': 'sodium bisulfite'}]",
"role": "assistant"
}
] |
A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.
|
[
{
"ade": "one patient became unconscious",
"drug": "cotrimoxazole"
},
{
"ade": "hyperkalaemia",
"drug": "cotrimoxazole"
},
{
"ade": "increased urinary N-acetyl glucosaminase",
"drug": "cotrimoxazole"
},
{
"ade": "elevation of serum creatinine and blood urea",
"drug": "cotrimoxazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.",
"role": "user"
},
{
"content": "[{'ade': 'one patient became unconscious', 'drug': 'cotrimoxazole'}, {'ade': 'hyperkalaemia', 'drug': 'cotrimoxazole'}, {'ade': 'increased urinary N-acetyl glucosaminase', 'drug': 'cotrimoxazole'}, {'ade': 'elevation of serum creatinine and blood urea', 'drug': 'cotrimoxazole'}]",
"role": "assistant"
}
] |
Hypoglycemia induced by long-acting somatostatin analogues in a patient with nonfunctional neuroendocrine tumor.
|
[
{
"ade": "Hypoglycemia",
"drug": "somatostatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hypoglycemia induced by long-acting somatostatin analogues in a patient with nonfunctional neuroendocrine tumor.",
"role": "user"
},
{
"content": "[{'ade': 'Hypoglycemia', 'drug': 'somatostatin'}]",
"role": "assistant"
}
] |
When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug.
|
[
{
"ade": "life-threatening arrhythmias",
"drug": "pilsicainide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug.",
"role": "user"
},
{
"content": "[{'ade': 'life-threatening arrhythmias', 'drug': 'pilsicainide'}]",
"role": "assistant"
}
] |
A case of severe visual loss following a single dose of vincristine is described.
|
[
{
"ade": "severe visual loss",
"drug": "vincristine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of severe visual loss following a single dose of vincristine is described.",
"role": "user"
},
{
"content": "[{'ade': 'severe visual loss', 'drug': 'vincristine'}]",
"role": "assistant"
}
] |
A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.
|
[
{
"ade": "seizures",
"drug": "lorazepam"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.",
"role": "user"
},
{
"content": "[{'ade': 'seizures', 'drug': 'lorazepam'}]",
"role": "assistant"
}
] |
Generalised cutaneous rash associated with ganciclovir therapy has rarely been reported in literature.
|
[
{
"ade": "Generalised cutaneous rash",
"drug": "ganciclovir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Generalised cutaneous rash associated with ganciclovir therapy has rarely been reported in literature.",
"role": "user"
},
{
"content": "[{'ade': 'Generalised cutaneous rash', 'drug': 'ganciclovir'}]",
"role": "assistant"
}
] |
Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus sustained an anaphylactoid reaction after the intravenous administration of 50% solution of dextrose.
|
[
{
"ade": "anaphylactoid reaction",
"drug": "dextrose"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus sustained an anaphylactoid reaction after the intravenous administration of 50% solution of dextrose.",
"role": "user"
},
{
"content": "[{'ade': 'anaphylactoid reaction', 'drug': 'dextrose'}]",
"role": "assistant"
}
] |
OBJECTIVES: To describe the clinicopathologic features of 3 patients with CML who rapidly progressed from chronic phase to blast crisis while taking imatinib and to perform a review of the literature.
|
[
{
"ade": "blast crisis",
"drug": "imatinib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVES: To describe the clinicopathologic features of 3 patients with CML who rapidly progressed from chronic phase to blast crisis while taking imatinib and to perform a review of the literature.",
"role": "user"
},
{
"content": "[{'ade': 'blast crisis', 'drug': 'imatinib'}]",
"role": "assistant"
}
] |
Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine.
|
[
{
"ade": "tardive OGC",
"drug": "clozapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine.",
"role": "user"
},
{
"content": "[{'ade': 'tardive OGC', 'drug': 'clozapine'}]",
"role": "assistant"
}
] |
We describe two cases of PSVT that changed to non-sustained polymorphic ventricular tachycardia after administration of verapamil.
|
[
{
"ade": "non-sustained polymorphic ventricular tachycardia",
"drug": "verapamil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe two cases of PSVT that changed to non-sustained polymorphic ventricular tachycardia after administration of verapamil.",
"role": "user"
},
{
"content": "[{'ade': 'non-sustained polymorphic ventricular tachycardia', 'drug': 'verapamil'}]",
"role": "assistant"
}
] |
Gemcitabine-related radiation recall preferentially involves internal tissue and organs.
|
[
{
"ade": "radiation recall",
"drug": "Gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gemcitabine-related radiation recall preferentially involves internal tissue and organs.",
"role": "user"
},
{
"content": "[{'ade': 'radiation recall', 'drug': 'Gemcitabine'}]",
"role": "assistant"
}
] |
We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.
|
[
{
"ade": "acute myeloid leukaemia",
"drug": "tamoxifen"
},
{
"ade": "AML",
"drug": "tamoxifen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.",
"role": "user"
},
{
"content": "[{'ade': 'acute myeloid leukaemia', 'drug': 'tamoxifen'}, {'ade': 'AML', 'drug': 'tamoxifen'}]",
"role": "assistant"
}
] |
The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.
|
[
{
"ade": "pulmonary hypertension",
"drug": "protamine"
},
{
"ade": "bronchoconstriction",
"drug": "protamine"
},
{
"ade": "severe hemodynamic deterioration",
"drug": "protamine"
},
{
"ade": "systemic hypotension",
"drug": "protamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.",
"role": "user"
},
{
"content": "[{'ade': 'pulmonary hypertension', 'drug': 'protamine'}, {'ade': 'bronchoconstriction', 'drug': 'protamine'}, {'ade': 'severe hemodynamic deterioration', 'drug': 'protamine'}, {'ade': 'systemic hypotension', 'drug': 'protamine'}]",
"role": "assistant"
}
] |
To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.
|
[
{
"ade": "granulomatous reaction",
"drug": "calcium hydroxylapatite"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.",
"role": "user"
},
{
"content": "[{'ade': 'granulomatous reaction', 'drug': 'calcium hydroxylapatite'}]",
"role": "assistant"
}
] |
RESULTS: We recently experienced a case of fatal erlotinib-induced ILD, diagnosed based on clinical and radiologic findings, which occurred in a patient with radiation fibrosis.
|
[
{
"ade": "ILD",
"drug": "erlotinib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: We recently experienced a case of fatal erlotinib-induced ILD, diagnosed based on clinical and radiologic findings, which occurred in a patient with radiation fibrosis.",
"role": "user"
},
{
"content": "[{'ade': 'ILD', 'drug': 'erlotinib'}]",
"role": "assistant"
}
] |
When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.
|
[
{
"ade": "inflammation",
"drug": "cyanamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.",
"role": "user"
},
{
"content": "[{'ade': 'inflammation', 'drug': 'cyanamide'}]",
"role": "assistant"
}
] |
Gold-salt therapy may result in damage to proximal tubules that leak renal tubular antigens, which in turn complex with autoantibody and produce an autoimmune membranous nephropathy.
|
[
{
"ade": "damage to proximal tubules",
"drug": "Gold-salt"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gold-salt therapy may result in damage to proximal tubules that leak renal tubular antigens, which in turn complex with autoantibody and produce an autoimmune membranous nephropathy.",
"role": "user"
},
{
"content": "[{'ade': 'damage to proximal tubules', 'drug': 'Gold-salt'}]",
"role": "assistant"
}
] |
Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.
|
[
{
"ade": "pericardial effusion",
"drug": "gemcitabine"
},
{
"ade": "radiation recall reaction",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.",
"role": "user"
},
{
"content": "[{'ade': 'pericardial effusion', 'drug': 'gemcitabine'}, {'ade': 'radiation recall reaction', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
The relationship between infliximab treatment and lymphoma in Crohn's disease.
|
[
{
"ade": "lymphoma",
"drug": "infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The relationship between infliximab treatment and lymphoma in Crohn's disease.",
"role": "user"
},
{
"content": "[{'ade': 'lymphoma', 'drug': 'infliximab'}]",
"role": "assistant"
}
] |
A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.
|
[
{
"ade": "normotensive scleroderma renal crisis",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.",
"role": "user"
},
{
"content": "[{'ade': 'normotensive scleroderma renal crisis', 'drug': 'methylprednisolone'}]",
"role": "assistant"
}
] |
Detection of activated eosinophils in nasal polyps of an aspirin-induced asthma patient.
|
[
{
"ade": "asthma",
"drug": "aspirin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Detection of activated eosinophils in nasal polyps of an aspirin-induced asthma patient.",
"role": "user"
},
{
"content": "[{'ade': 'asthma', 'drug': 'aspirin'}]",
"role": "assistant"
}
] |
No cases of renal acidosis, and only one case of nephrogenic diabetes insipidus, has been previously reported as a complication of foscarnet treatment.
|
[
{
"ade": "nephrogenic diabetes insipidus",
"drug": "foscarnet"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: No cases of renal acidosis, and only one case of nephrogenic diabetes insipidus, has been previously reported as a complication of foscarnet treatment.",
"role": "user"
},
{
"content": "[{'ade': 'nephrogenic diabetes insipidus', 'drug': 'foscarnet'}]",
"role": "assistant"
}
] |
DISCUSSION: Amphotericin B deoxycholate has been reported to produce significant cardiac toxicity, with ventricular arrhythmias and bradycardia reported in overdoses in children and in adults with preexisting cardiac disease, even when administered in conventional dosages and infusion rates.
|
[
{
"ade": "bradycardia",
"drug": "Amphotericin B deoxycholate"
},
{
"ade": "ventricular arrhythmias",
"drug": "Amphotericin B deoxycholate"
},
{
"ade": "cardiac toxicity",
"drug": "Amphotericin B deoxycholate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: DISCUSSION: Amphotericin B deoxycholate has been reported to produce significant cardiac toxicity, with ventricular arrhythmias and bradycardia reported in overdoses in children and in adults with preexisting cardiac disease, even when administered in conventional dosages and infusion rates.",
"role": "user"
},
{
"content": "[{'ade': 'bradycardia', 'drug': 'Amphotericin B deoxycholate'}, {'ade': 'ventricular arrhythmias', 'drug': 'Amphotericin B deoxycholate'}, {'ade': 'cardiac toxicity', 'drug': 'Amphotericin B deoxycholate'}]",
"role": "assistant"
}
] |
OBJECTIVE: The authors described a case of interferon-induced psychosis as a framework to review the literature and discuss the decision to pursue antiviral treatment in psychiatrically ill patients with hepatitis C.
|
[
{
"ade": "psychosis",
"drug": "interferon"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: The authors described a case of interferon-induced psychosis as a framework to review the literature and discuss the decision to pursue antiviral treatment in psychiatrically ill patients with hepatitis C.",
"role": "user"
},
{
"content": "[{'ade': 'psychosis', 'drug': 'interferon'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.
|
[
{
"ade": "sclerosing glomerulonephritis",
"drug": "Anastrozole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.",
"role": "user"
},
{
"content": "[{'ade': 'sclerosing glomerulonephritis', 'drug': 'Anastrozole'}]",
"role": "assistant"
}
] |
Several hypersensitivity reactions to cloxacillin have been reported, although IgE-mediated allergic reactions to the drug are rare and there is little information about possible tolerance to other semisynthetic penicillins or cephalosporins in patients with cloxacillin allergy.
|
[
{
"ade": "hypersensitivity",
"drug": "cloxacillin"
},
{
"ade": "IgE-mediated allergic reactions",
"drug": "cloxacillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Several hypersensitivity reactions to cloxacillin have been reported, although IgE-mediated allergic reactions to the drug are rare and there is little information about possible tolerance to other semisynthetic penicillins or cephalosporins in patients with cloxacillin allergy.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity', 'drug': 'cloxacillin'}, {'ade': 'IgE-mediated allergic reactions', 'drug': 'cloxacillin'}]",
"role": "assistant"
}
] |
We report 3 cases of HIV-1 infected patients who experienced symptomatic angiolipomas shortly after starting antiretroviral therapy including the protease inhibitor indinavir.
|
[
{
"ade": "angiolipomas",
"drug": "indinavir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report 3 cases of HIV-1 infected patients who experienced symptomatic angiolipomas shortly after starting antiretroviral therapy including the protease inhibitor indinavir.",
"role": "user"
},
{
"content": "[{'ade': 'angiolipomas', 'drug': 'indinavir'}]",
"role": "assistant"
}
] |
Valvular heart disease in a patient taking benfluorex.
|
[
{
"ade": "Valvular heart disease",
"drug": "benfluorex"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Valvular heart disease in a patient taking benfluorex.",
"role": "user"
},
{
"content": "[{'ade': 'Valvular heart disease', 'drug': 'benfluorex'}]",
"role": "assistant"
}
] |
During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.
|
[
{
"ade": "ataxia",
"drug": "HDARAC"
},
{
"ade": "dysarthria",
"drug": "HDARAC"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.",
"role": "user"
},
{
"content": "[{'ade': 'ataxia', 'drug': 'HDARAC'}, {'ade': 'dysarthria', 'drug': 'HDARAC'}]",
"role": "assistant"
}
] |
Severe vancomycin-induced anaphylactic reaction.
|
[
{
"ade": "anaphylactic reaction",
"drug": "vancomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe vancomycin-induced anaphylactic reaction.",
"role": "user"
},
{
"content": "[{'ade': 'anaphylactic reaction', 'drug': 'vancomycin'}]",
"role": "assistant"
}
] |
Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.
|
[
{
"ade": "anemia",
"drug": "enalapril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.",
"role": "user"
},
{
"content": "[{'ade': 'anemia', 'drug': 'enalapril'}]",
"role": "assistant"
}
] |
The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.
|
[
{
"ade": "diabetic ketoacidosis",
"drug": "perospirone hydrochloride"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.",
"role": "user"
},
{
"content": "[{'ade': 'diabetic ketoacidosis', 'drug': 'perospirone hydrochloride'}]",
"role": "assistant"
}
] |
Case report: acute renal failure after administering intravenous immunoglobulin.
|
[
{
"ade": "acute renal failure",
"drug": "immunoglobulin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Case report: acute renal failure after administering intravenous immunoglobulin.",
"role": "user"
},
{
"content": "[{'ade': 'acute renal failure', 'drug': 'immunoglobulin'}]",
"role": "assistant"
}
] |
Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine.
|
[
{
"ade": "Reactivation of cytomegalovirus",
"drug": "azathioprine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine.",
"role": "user"
},
{
"content": "[{'ade': 'Reactivation of cytomegalovirus', 'drug': 'azathioprine'}]",
"role": "assistant"
}
] |
CONCLUSION: Zidovudine is well a known cause of anaemia and thus should be used with caution in the initiation of antiretroviral therapy.
|
[
{
"ade": "anaemia",
"drug": "Zidovudine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: Zidovudine is well a known cause of anaemia and thus should be used with caution in the initiation of antiretroviral therapy.",
"role": "user"
},
{
"content": "[{'ade': 'anaemia', 'drug': 'Zidovudine'}]",
"role": "assistant"
}
] |
Recurrent hypotension immediately after seizures in nortriptyline overdose.
|
[
{
"ade": "Recurrent hypotension",
"drug": "nortriptyline"
},
{
"ade": "seizures",
"drug": "nortriptyline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Recurrent hypotension immediately after seizures in nortriptyline overdose.",
"role": "user"
},
{
"content": "[{'ade': 'Recurrent hypotension', 'drug': 'nortriptyline'}, {'ade': 'seizures', 'drug': 'nortriptyline'}]",
"role": "assistant"
}
] |
This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor.
|
[
{
"ade": "HBV reactivation",
"drug": "rituximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor.",
"role": "user"
},
{
"content": "[{'ade': 'HBV reactivation', 'drug': 'rituximab'}]",
"role": "assistant"
}
] |
Cefuroxime-induced immune hemolysis.
|
[
{
"ade": "immune hemolysis",
"drug": "Cefuroxime"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cefuroxime-induced immune hemolysis.",
"role": "user"
},
{
"content": "[{'ade': 'immune hemolysis', 'drug': 'Cefuroxime'}]",
"role": "assistant"
}
] |
Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.
|
[
{
"ade": "Carbamazepine toxicity",
"drug": "clarithromycin"
},
{
"ade": "Carbamazepine toxicity",
"drug": "Carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.",
"role": "user"
},
{
"content": "[{'ade': 'Carbamazepine toxicity', 'drug': 'clarithromycin'}, {'ade': 'Carbamazepine toxicity', 'drug': 'Carbamazepine'}]",
"role": "assistant"
}
] |
We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome.
|
[
{
"ade": "hypersensitivity syndrome",
"drug": "dapsone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity syndrome', 'drug': 'dapsone'}]",
"role": "assistant"
}
] |
Here, we report a case of angio-oedema associated with VRC therapy.
|
[
{
"ade": "angio-oedema",
"drug": "VRC"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Here, we report a case of angio-oedema associated with VRC therapy.",
"role": "user"
},
{
"content": "[{'ade': 'angio-oedema', 'drug': 'VRC'}]",
"role": "assistant"
}
] |
A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy.
|
[
{
"ade": "sensori-neural hearing loss",
"drug": "vincristine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'sensori-neural hearing loss', 'drug': 'vincristine'}]",
"role": "assistant"
}
] |
RESULTS: Both cases presented here describe corneal ulcers that persisted and showed signs of worsening during weeks of frequent topical dosing with moxifloxacin.
|
[
{
"ade": "corneal ulcers",
"drug": "moxifloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: Both cases presented here describe corneal ulcers that persisted and showed signs of worsening during weeks of frequent topical dosing with moxifloxacin.",
"role": "user"
},
{
"content": "[{'ade': 'corneal ulcers', 'drug': 'moxifloxacin'}]",
"role": "assistant"
}
] |
Despite the low dosage of warfarin, international normalized ratio (INR) was markedly elevated from 1.15 to 11.28 for only 4 days, and bleeding symptoms concurrently developed.
|
[
{
"ade": "bleeding symptoms",
"drug": "warfarin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Despite the low dosage of warfarin, international normalized ratio (INR) was markedly elevated from 1.15 to 11.28 for only 4 days, and bleeding symptoms concurrently developed.",
"role": "user"
},
{
"content": "[{'ade': 'bleeding symptoms', 'drug': 'warfarin'}]",
"role": "assistant"
}
] |
Metabolic balance studies and rechallenge with hydrochlorothiazide were undertaken to investigate the mechanism of the thiazide-induced hyponatremia.
|
[
{
"ade": "hyponatremia",
"drug": "hydrochlorothiazide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Metabolic balance studies and rechallenge with hydrochlorothiazide were undertaken to investigate the mechanism of the thiazide-induced hyponatremia.",
"role": "user"
},
{
"content": "[{'ade': 'hyponatremia', 'drug': 'hydrochlorothiazide'}]",
"role": "assistant"
}
] |
RESULTS: Our patient developed Crohn's disease while on Copaxone treatment as a consequence of long-term immunosuppression.
|
[
{
"ade": "long-term immunosuppression",
"drug": "Copaxone"
},
{
"ade": "Crohn's disease",
"drug": "Copaxone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: Our patient developed Crohn's disease while on Copaxone treatment as a consequence of long-term immunosuppression.",
"role": "user"
},
{
"content": "[{'ade': 'long-term immunosuppression', 'drug': 'Copaxone'}, {'ade': \"Crohn's disease\", 'drug': 'Copaxone'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Cicatrization in the substantia propria of the conjunctiva by excessive lymphocytic infiltration after topically administered antiglaucoma drugs including dipivefrin is a possible mechanism of action for entropion.
|
[
{
"ade": "entropion",
"drug": "dipivefrin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Cicatrization in the substantia propria of the conjunctiva by excessive lymphocytic infiltration after topically administered antiglaucoma drugs including dipivefrin is a possible mechanism of action for entropion.",
"role": "user"
},
{
"content": "[{'ade': 'entropion', 'drug': 'dipivefrin'}]",
"role": "assistant"
}
] |
Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy.
|
[
{
"ade": "Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis', 'drug': 'propylthiouracil'}]",
"role": "assistant"
}
] |
This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli.
|
[
{
"ade": "severe lupus erythematosus",
"drug": "CY"
},
{
"ade": "severe lupus erythematosus",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli.",
"role": "user"
},
{
"content": "[{'ade': 'severe lupus erythematosus', 'drug': 'CY'}, {'ade': 'severe lupus erythematosus', 'drug': 'cyclophosphamide'}]",
"role": "assistant"
}
] |
Methotrexate-induced liver cirrhosis.
|
[
{
"ade": "liver cirrhosis",
"drug": "Methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methotrexate-induced liver cirrhosis.",
"role": "user"
},
{
"content": "[{'ade': 'liver cirrhosis', 'drug': 'Methotrexate'}]",
"role": "assistant"
}
] |
1. Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment (mean 0.62 +/- 0.15 mg/day) compared with during the period of high-dose period (mean 1.08 +/- 0.28 mg/day).
|
[
{
"ade": "Changes in the plasma cortisol level",
"drug": "alprazolam"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: 1. Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment (mean 0.62 +/- 0.15 mg/day) compared with during the period of high-dose period (mean 1.08 +/- 0.28 mg/day).",
"role": "user"
},
{
"content": "[{'ade': 'Changes in the plasma cortisol level', 'drug': 'alprazolam'}]",
"role": "assistant"
}
] |
Fatal toxic epidermal necrolysis related to lamotrigine administration.
|
[
{
"ade": "Fatal toxic epidermal necrolysis",
"drug": "lamotrigine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fatal toxic epidermal necrolysis related to lamotrigine administration.",
"role": "user"
},
{
"content": "[{'ade': 'Fatal toxic epidermal necrolysis', 'drug': 'lamotrigine'}]",
"role": "assistant"
}
] |
Risperidone withdrawal-related respiratory dyskinesia: a case diagnosed by spirography and fibroscopy.
|
[
{
"ade": "respiratory dyskinesia",
"drug": "Risperidone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Risperidone withdrawal-related respiratory dyskinesia: a case diagnosed by spirography and fibroscopy.",
"role": "user"
},
{
"content": "[{'ade': 'respiratory dyskinesia', 'drug': 'Risperidone'}]",
"role": "assistant"
}
] |
Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.
|
[
{
"ade": "hyperpigmentation",
"drug": "bleomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.",
"role": "user"
},
{
"content": "[{'ade': 'hyperpigmentation', 'drug': 'bleomycin'}]",
"role": "assistant"
}
] |
Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.
|
[
{
"ade": "malignant lymphoma",
"drug": "MTX"
},
{
"ade": "malignant lymphoma",
"drug": "Methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.",
"role": "user"
},
{
"content": "[{'ade': 'malignant lymphoma', 'drug': 'MTX'}, {'ade': 'malignant lymphoma', 'drug': 'Methotrexate'}]",
"role": "assistant"
}
] |
The psychotic behavior resolved completely soon after the discontinuation of levetiracetam.
|
[
{
"ade": "psychotic behavior",
"drug": "levetiracetam"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The psychotic behavior resolved completely soon after the discontinuation of levetiracetam.",
"role": "user"
},
{
"content": "[{'ade': 'psychotic behavior', 'drug': 'levetiracetam'}]",
"role": "assistant"
}
] |
The oligohidrosis caused by zonisamide was reversible in that the patient regained the ability to sweat within 2 weeks of the cessation of drug administration.
|
[
{
"ade": "oligohidrosis",
"drug": "zonisamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The oligohidrosis caused by zonisamide was reversible in that the patient regained the ability to sweat within 2 weeks of the cessation of drug administration.",
"role": "user"
},
{
"content": "[{'ade': 'oligohidrosis', 'drug': 'zonisamide'}]",
"role": "assistant"
}
] |
Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.
|
[
{
"ade": "Fatal acute encephalomyelitis",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.",
"role": "user"
},
{
"content": "[{'ade': 'Fatal acute encephalomyelitis', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.
|
[
{
"ade": "hyperhidrosis",
"drug": "Morphine"
},
{
"ade": "facial flushing",
"drug": "Morphine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.",
"role": "user"
},
{
"content": "[{'ade': 'hyperhidrosis', 'drug': 'Morphine'}, {'ade': 'facial flushing', 'drug': 'Morphine'}]",
"role": "assistant"
}
] |
METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.
|
[
{
"ade": "nonoliguric renal failure",
"drug": "acyclovir"
},
{
"ade": "coma",
"drug": "acyclovir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.",
"role": "user"
},
{
"content": "[{'ade': 'nonoliguric renal failure', 'drug': 'acyclovir'}, {'ade': 'coma', 'drug': 'acyclovir'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon alpha administration.
|
[
{
"ade": "Optic neuritis",
"drug": "interferon alpha"
},
{
"ade": "neurological signs",
"drug": "interferon alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon alpha administration.",
"role": "user"
},
{
"content": "[{'ade': 'Optic neuritis', 'drug': 'interferon alpha'}, {'ade': 'neurological signs', 'drug': 'interferon alpha'}]",
"role": "assistant"
}
] |
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