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34,748,364
The mental health of Medicare beneficiaries with disabilities during the COVID-19 pandemic.
Rehabilitation psychology
Rehabil Psychol
67
1
10.1037/rep0000427
eng
2,022
2
null
2,021
11
8
[PURPOSE] During the coronavirus disease 2019 (COVID-19) pandemic, there was a tremendous increase in adverse mental and behavioral health symptoms. People with disabilities who are Medicare beneficiaries (under 65) are a vulnerable population, frequently having multiple chronic conditions, and facing a number of socia...
null
0.975
83
Clinical Psychology; Physical Therapy, Sports Therapy and Rehabilitation; Rehabilitation; Psychiatry and Mental Health
Health Professions; Medicine; Psychology
2,022
34,748,170
Improved Glycemic Control Observed in Children with Type 1 Diabetes Following the Introduction of Smart Insulin Pens: A Real-World Study.
Diabetes therapy : research, treatment and education of diabetes and related disorders
Diabetes Ther
13
1
10.1007/s13300-021-01177-w
eng
2,022
1
null
2,021
11
8
[INTRODUCTION] Many challenges are associated with optimizing glycemic control in pediatric patients with type 1 diabetes (T1D); combining data from smart insulin pens and continuous glucose monitoring (CGM) could mitigate some of these obstacles. [METHODS] This one-arm, prospective, observational study investigated th...
Adolescent; Biomedical technology; Child; Diabetes mellitus type 1; Insulin; Smart insulin pens
1.039
59
Endocrinology, Diabetes and Metabolism; Internal Medicine
Medicine
2,022
34,748,088
Evaluation of long-term survival in patients with severe comorbidities after endoscopic submucosal dissection for esophageal squamous cell carcinoma.
Surgical endoscopy
Surg Endosc
36
7
10.1007/s00464-021-08859-3
eng
2,022
7
null
2,021
11
8
[BACKGROUND] Endoscopic submucosal dissection (ESD) is becoming widely popular as a less invasive treatment option for superficial esophageal squamous cell carcinoma. However, data on long-term survival after esophageal ESD in patients with severe comorbidities are limited. This study aimed to evaluate long-term surviv...
Endoscopic submucosal dissection; Esophageal cancer; Long-term outcome; Propensity score matching
1.124
178
Surgery
Medicine
2,022
34,748,028
Real-world efficacy and safety of anlotinib as third- or further-line treatment in refractory small cell lung cancer.
Journal of cancer research and clinical oncology
J Cancer Res Clin Oncol
148
10
10.1007/s00432-021-03848-4
eng
2,022
10
null
2,021
11
8
[PURPOSE] As a novel antiangiogenic multi-target tyrosine kinase inhibitor recently approved in China, anlotinib has exhibited promising anticancer efficacy and acceptable safety profile in the salvage treatment of small cell lung cancer (SCLC) in clinical trials. Here we retrospectively investigated the efficacy and s...
Adverse events; Anlotinib; Efficacy; Small cell lung cancer; Survival
1.017
114
Medicine; Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
34,748,010
Racial and Ethnic Disparities in the Use of Prostate Magnetic Resonance Imaging Following an Elevated Prostate-Specific Antigen Test.
JAMA network open
JAMA Netw Open
4
11
10.1001/jamanetworkopen.2021.32388
eng
2,021
11
1
2,021
11
1
[IMPORTANCE] Prostate cancer screening and diagnosis exhibit known racial and ethnic disparities. Whether these disparities persist in prostate magnetic resonance imaging (MRI) utilization after elevated prostate-specific antigen (PSA) results is poorly understood. [OBJECTIVE] To assess potential racial and ethnic disp...
null
4.031
154
Medicine
Medicine
2,021
34,747,502
Clinical use of controlled oxygenated rewarming of kidney grafts prior to transplantation by ex vivo machine perfusion. A pilot study.
European journal of clinical investigation
Eur J Clin Invest
52
2
10.1111/eci.13691
eng
2,022
2
null
2,021
11
8
[BACKGROUND] Sudden restoration of normothermic conditions upon reperfusion of cold-stored grafts has been suggested to entail a massive energy demand not yet met by the cells that still suffer from hypothermic torpor. An adapted and gentle rise of graft temperature by ex-vivo machine perfusion has, therefore, been pro...
controlled rewarming; machine perfusion; rewarming injury; temperature paradox
1.3
126
Biochemistry; Clinical Biochemistry; Medicine
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
34,747,463
Econazole as adjuvant to conventional antibiotics is able to eradicate starvation-induced tolerant bacteria by causing proton motive force dissipation.
The Journal of antimicrobial chemotherapy
J Antimicrob Chemother
77
2
10.1093/jac/dkab384
eng
2,022
2
2
null
null
null
[OBJECTIVES] Bacterial antibiotic tolerance is responsible for the recalcitrance of chronic infections. This study aims to investigate a potential drug that can effectively kill antibiotic-tolerant bacteria and evaluate the ability of this drug on the eradication of tolerant cells both in vitro and in vivo. [METHODS] T...
null
1.382
229
Infectious Diseases; Microbiology; Pharmacology; Pharmacology
Medicine; Pharmacology, Toxicology and Pharmaceutics
2,022
34,747,461
Sex difference in the risk factor distributions and outcomes after coronary artery bypass graft surgery in the young population.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Eur J Cardiothorac Surg
62
1
10.1093/ejcts/ezab475
eng
2,022
6
15
null
null
null
[OBJECTIVES] Coronary artery disease is becoming a major health concern in the young population. Male and female patients may experience different journeys after coronary artery disease events. We aimed to evaluate risk factors and compare outcomes between young male and female patients undergoing coronary artery bypas...
All-cause mortality; Premature coronary artery disease; Premature isolated coronary artery bypass graft; Revascularization
1.183
158
Cardiology and Cardiovascular Medicine; Medicine; Pulmonary and Respiratory Medicine; Surgery
Medicine
2,022
34,747,308
The Histopathological Effect of Aloe Vera on the Wound Healing Process in a Surgically Created Tubularized Incised Plate Urethroplasty Model on Rats.
Journal of investigative surgery : the official journal of the Academy of Surgical Research
J Invest Surg
35
5
10.1080/08941939.2021.1999537
eng
2,022
5
null
2,021
11
7
[BACKGROUND] Hypospadias is a common congenital anomaly which is determined as an abnormal urethral opening on the ventral face of penis. The purpose of this rat model study was to research the effect of topically applied Aloe vera after a tubularized incised plate urethroplasty (TIPU). [METHODS] The TIPU model was app...
Aloe vera; hypospadias; rats; wound healing
0.415
48
Surgery
Medicine
2,022
34,747,262
Microbiological and Antimicrobial Pattern of Diabetic Foot Ulcers at a Tertiary Care Center in East China.
The international journal of lower extremity wounds
Int J Low Extrem Wounds
23
1
10.1177/15347346211055972
eng
2,024
3
null
2,021
11
6
[BACKGROUND] Diabetic foot infections (DFIs) are the most complex and challenging pathological state, characterized by high complexity of management, morbidity, and mortality. Empirical antimicrobial administration is needed before the identification of the causative organisms. Microbiological profile of the diabetic f...
null
0.511
52
Surgery; Medicine
Medicine
2,024
34,747,090
Kirkpatrick's evaluation of the effect of a nursing innovation team training for clinical nurses.
Journal of nursing management
J Nurs Manag
30
7
10.1111/jonm.13504
eng
2,022
10
null
2,021
11
18
[AIM] This study aims to design a 100-h training programme for nursing innovation teams and to evaluate the effect of this training programme using Kirkpatrick's model. [BACKGROUND] The innovative capability of nurses is a powerful driver for the development of the nursing discipline, and it is currently at a low to me...
Kirkpatrick's evaluation; nursing innovation; team training
1.341
103
Leadership and Management
Nursing
2,022
34,746,655
Efficacy of orthopaedic-inspired osteoporosis management: a secondary fracture prevention program after a fracture of the hip in a prospective randomized study.
OTA international : the open access journal of orthopaedic trauma
OTA Int
4
2
10.1097/OI9.0000000000000122
eng
2,021
6
null
2,021
3
22
[AIMS] Patients who present with fragility fractures are consistently under-evaluated and under-treated for underlying osteoporosis. This point-of-care represents a lost opportunity to prevent future fractures. This 2-arm study evaluated the success by an orthopaedic department in osteoporosis evaluation and initiating...
FLS; fracture liason service; fragility hip fracture; osteoporosis
null
13
Orthopedics and Sports Medicine; Surgery
Medicine
2,021
34,746,324
Professional Pitchers Display Differences in UCL Morphology and Elbow Gapping During Moving Valgus Stress Testing After UCL Reconstruction.
Orthopaedic journal of sports medicine
Orthop J Sports Med
9
11
10.1177/23259671211035734
eng
2,021
11
null
2,021
11
1
[BACKGROUND] Ulnar collateral ligament (UCL) reconstruction (UCLR) of the elbow has received much attention given the rise in incidence among baseball pitchers. Stress ultrasonography has been demonstrated to be a critical evaluation tool of the UCL. No study has dynamically evaluated the ability of UCLR to restore nor...
baseball; moving valgus stress test; ulnar collateral ligament; ultrasound
1.037
68
Orthopedics and Sports Medicine
Medicine
2,021
34,745,325
The Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis.
Computational and mathematical methods in medicine
Comput Math Methods Med
2021
null
10.1155/2021/4487393
eng
2,021
null
null
2,021
10
27
[BACKGROUND] Ischemic stroke combined with hypertension can increase risks of stroke recurrence and death. [AIM] The aim of this study is to investigate the clinical efficacy of clopidogrel bisulfate tablets combined with olmesartan medoxomil in the treatment of ischemic stroke patients with hypertension and the effect...
null
null
null
null
null
null
34,745,303
Use of Traditional Chinese Medicine and Its Impact on Medical Cost among Urban Ischemic Stroke Inpatients in China: A National Cross-Sectional Study.
Evidence-based complementary and alternative medicine : eCAM
Evid Based Complement Alternat Med
2021
null
10.1155/2021/8554829
eng
2,021
null
null
2,021
10
29
[BACKGROUND] Traditional Chinese medicine (TCM) has long been widely adopted by the Chinese people and has been covered by China's basic medical insurance schemes to treat ischemic stroke. Previous research has mainly highlighted the therapy effect of TCM on ischemic stroke patients. Some studies have demonstrated that...
null
null
null
null
null
null
34,744,999
Focal Thyroid Incidentalomas on [18]F-FDG PET/CT: A Systematic Review and Meta-Analysis on Prevalence, Risk of Malignancy and Inconclusive Fine Needle Aspiration.
Frontiers in endocrinology
Front Endocrinol (Lausanne)
12
null
10.3389/fendo.2021.723394
eng
2,021
null
null
2,021
10
20
[BACKGROUND] The rising demand for [18]F-fluorodeoxyglucose positron emission tomography with computed tomography ([18]F-FDG PET/CT) has led to an increase of thyroid incidentalomas. Current guidelines are restricted in giving options to tailor diagnostics and to suit the individual patient. [OBJECTIVES] We aimed at ex...
FDG (18F-fluorodeoxyglucose)-PET/CT; incidentaloma; thyroid; thyroid cancer; thyroid nodule
1.375
138
Endocrinology, Diabetes and Metabolism
Medicine
2,021
34,744,188
Religious Congregations' Technological and Financial Capacities on the Eve of the COVID-19 Pandemic.
Review of religious research
Rev Relig Res
64
1
10.1007/s13644-021-00477-8
eng
2,022
null
null
2,021
11
2
[BACKGROUND] The COVID-19 pandemic dramatically upended religious life and placed significant strain on religious congregations. However, the effects of the pandemic were likely not felt evenly across the religious landscape. [PURPOSE] We used data from the fourth wave of the National Congregations Study, gathered on t...
COVID-19; Congregations; Finances; National Congregations Study; Technology
null
null
null
null
null
34,744,067
The efficacy of transcatheter arterial embolization for knee pain on patients with knee osteoarthritis: A case series.
Journal of back and musculoskeletal rehabilitation
J Back Musculoskelet Rehabil
35
4
10.3233/BMR-210043
eng
2,022
null
null
null
null
null
[BACKGROUND] Knee osteoarthritis (OA) is accompanied by inflammation and angiogenesis. Modifying angiogenesis through transcatheter arterial embolization (TAE) can be a potential treatment for knee OA. [OBJECTIVE] We subjected five OA knees in three patients to TAE and report the results of our post-treatment observati...
Knee; embolization; osteoarthritis; pain
null
null
null
null
null
34,743,673
Modjaw® device: Analysis of mandibular kinematics recorded for a group of asymptomatic subjects.
Cranio : the journal of craniomandibular practice
Cranio
42
5
10.1080/08869634.2021.2000790
eng
2,024
9
null
2,021
11
6
[OBJECTIVE] To assess the repeatability and kinematic data of Modjaw® recordings from a group of asymptomatic patients. [METHODS] Modjaw® mandibular kinematic data were recorded for 22 asymptomatic volunteers (DC/TMD questionnaire). Sagittal (SCI at 3 and 5 mm) and transversal (TCI at 4 mm) condylar inclination values ...
Bennett angle; Condylar inclination; mandibular kinematics; temporomandibular joint
null
null
null
null
null
34,743,632
Artesunate attenuates inflammatory injury and inhibits the NF-κB pathway in a mouse model of cerebral ischemia.
The Journal of international medical research
J Int Med Res
49
11
10.1177/03000605211053549
eng
2,021
11
null
null
null
null
[OBJECTIVE] Inflammation is an important factor in the pathological process of cerebral ischemia. Artesunate exhibits a broad range of anti-inflammatory properties in many diseases. We investigated the potential protective effect of artesunate against cerebral ischemia and the related mechanisms. [METHODS] Mice were di...
Artesunate; inflammation; ischemic stroke; microglia; neuroprotective effect
0.366
74
Biochemistry; Biochemistry; Medicine; Cell Biology
Biochemistry, Genetics and Molecular Biology; Medicine
2,021
34,743,275
CDKN1A (p21 gene) polymorphisms correlates with age in esophageal cancer.
Molecular biology reports
Mol Biol Rep
49
1
10.1007/s11033-021-06865-1
eng
2,022
1
null
2,021
11
7
[BACKGROUND] CDKN1A gene encoding p21 is an important tumour supressor involved in the pathogenesis of cancers. A few studies have been devoted to the association between CDKN1A single nucleotide polymorphisms (SNPs) and esophageal cancer (EC) in China, India and Iran. The aim of this case-control study was to investig...
CDKN1A; Esophageal cancer; Polymorphism; p21
0.578
96
Medicine; Genetics; Molecular Biology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
34,743,021
Hepatitis B virus genotypes and subgenotypes and the natural history and epidemiology of hepatitis B.
Annals of hepatology
Ann Hepatol
27 Suppl 1
null
10.1016/j.aohep.2021.100574
eng
2,022
1
null
2,021
11
4
[INTRODUCTION AND OBJECTIVES] Espírito Santo state is considered a region with a higher frequency of hepatitis B virus infection. This study characterized demographic, epidemiological, laboratory, virological and clinical aspects of 587 chronic HBV carriers followed up at the University of Espírito Santo Hospital. [MAT...
Brazil; Genotype; Hepatitis B; Natural history of disease
0.859
70
Hepatology; Medicine
Medicine
2,022
34,742,873
Survivorship and Radiographic Evaluation of Metaphyseal Cones With Short Cemented Stems in Revision Total Knee Arthroplasty.
The Journal of arthroplasty
J Arthroplasty
37
2
10.1016/j.arth.2021.10.027
eng
2,022
2
null
2,021
11
3
[BACKGROUND] The purpose of this study is to evaluate the survivorship and radiographic outcomes of a single design of metaphyseal cone used in conjunction with short cemented stems. [METHODS] A retrospective analysis was conducted of revision total knee arthroplasty (rTKA) patients (June 2015 to December 2017) using p...
Survivorship; aseptic loosening; cemented stems; metaphyseal cones; revision total knee arthroplasty
2.028
171
Orthopedics and Sports Medicine
Medicine
2,022
34,742,240
Genome-wide analysis of Dof transcription factors and their response to cold stress in rice (Oryza sativa L.).
BMC genomics
BMC Genomics
22
1
10.1186/s12864-021-08104-0
eng
2,021
11
6
2,021
11
6
[BACKGROUND] Rice (Oryza sativa L.) is a food crop for humans worldwide. However, temperature has an effect during the vegetative and reproductive stages. In high-latitude regions where rice is cultivated, cold stress is a major cause of yield loss and plant death. Research has identified a group of plant-specific tran...
Cold; Dof; Expression profiling; Rice; Stress response; Transcription factor
1.258
208
Biotechnology; Genetics
Biochemistry, Genetics and Molecular Biology
2,021
34,742,231
Reporting of methods to prepare, pilot and perform data extraction in systematic reviews: analysis of a sample of 152 Cochrane and non-Cochrane reviews.
BMC medical research methodology
BMC Med Res Methodol
21
1
10.1186/s12874-021-01438-z
eng
2,021
11
6
2,021
11
6
[BACKGROUND] Previous research on data extraction methods in systematic reviews has focused on single aspects of the process. We aimed to provide a deeper insight into these methods by analysing a current sample of reviews. [METHODS] We included systematic reviews of health interventions in humans published in English....
Data extraction; Evidence synthesis; Systematic review methods
1.933
176
Epidemiology; Health Informatics
Medicine
2,021
34,742,103
Somatosensory Plasticity in Hemiplegic Cerebral Palsy Following Constraint Induced Movement Therapy.
Pediatric neurology
Pediatr Neurol
126
null
10.1016/j.pediatrneurol.2021.09.019
eng
2,022
1
null
2,021
9
30
[BACKGROUND] Children with hemiplegic cerebral palsy (HCP) experience upper limb somatosensory and motor deficits. Although constraint-induced movement therapy (CIMT) improves motor function, its impact on somatosensory function remains underinvestigated. [OBJECTIVE] The objective of this study was to evaluate somatose...
Constraint-induced movement therapy; Hemiplegic cerebral palsy; Magnetoencephalography; Sensory function; Somatosensory evoked field
0.876
111
Pediatrics, Perinatology and Child Health; Developmental Neuroscience; Neurology; Neurology
Medicine; Neuroscience
2,022
34,742,052
Molnupiravir in COVID-19: A systematic review of literature.
Diabetes metabolic syndrome
Diabetes Metab Syndr
15
6
10.1016/j.dsx.2021.102329
eng
2,021
null
null
2,021
10
30
[BACKGROUND AND AIMS] Molnupiravir is a newer oral antiviral drug that has recently been tested in COVID-19. We aim to conduct a systematic review of literature to find out the efficacy and safety of molnupiravir in patients with COVID-19. [METHODS] We systematically searched the electronic database of PubMed, MedRxiv ...
COVID-19; EIDD-2801; MK-4482; Molnupiravir; SARS-CoV-2
null
null
null
null
null
34,741,860
Cystocolostomy as an unusual approach to recurrent pancreatic pseudocyst in a Ugandan male with dense hepatogastroduodenal adhesions: A case report.
International journal of surgery case reports
Int J Surg Case Rep
88
null
10.1016/j.ijscr.2021.106546
eng
2,021
11
null
2,021
11
2
[INTRODUCTION AND IMPORTANCE] Pancreatic pseudocyst is one of the most frequent late complications of acute pancreatitis with increasing prevalence in chronic pancreatitis. Other causes include abdominal trauma, biliary tract disease, and other idiopathic causes. 85% resolve spontaneously within 4-6 weeks. Intervention...
Case report; Cystocolostomy; Pancreatic pseudocyst; Pancreatitis; Uganda
0.198
31
Surgery
Medicine
2,021
34,741,631
Conventional white light imaging-assisted transurethral resection of bladder tumour (TURBT) versus IMAGE1S-assisted TURBT in non-muscle-invasive bladder cancer patients: trial protocol and 18 months results.
World journal of urology
World J Urol
40
3
10.1007/s00345-021-03866-4
eng
2,022
3
null
2,021
11
6
[PURPOSE] White light (WL) is the traditional imaging modality for transurethral resection of bladder tumour (TURBT). IMAGE1S is a likely addition. We compare 18-mo recurrence rates following TURBT using IMAGE1S versus WL guidance. [METHODS] Twelve international centers conducted a single-blinded randomized controlled ...
Image 1S imaging; Non-muscle-invasive bladder; Transurethral resection of bladder tumour; Tumour recurrence; White light imaging
1.014
104
Urology
Medicine
2,022
34,741,538
Insulin-like growth factor-1 and insulin-like growth factor binding protein-3: impact on early haematopoietic reconstitution following allogeneic haematopoietic stem cell transplantation.
European journal of haematology
Eur J Haematol
108
3
10.1111/ejh.13724
eng
2,022
3
null
2,021
11
12
[OBJECTIVES] The aim of the study was to investigate whether high endogenous levels of insulin-like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3) were related to a faster reconstitution of different blood cell populations in the early phase after allogeneic myeloablative haematopoietic stem cell transplan...
haematopoiesis; haematopoietic stem cell transplantation; immune reconstitution; insulin-like growth factor binding protein-3; insulin-like growth factor-1
1.094
99
Hematology; Medicine
Medicine
2,022
34,741,334
Pragmatic review of interventions to prevent inpatient hypoglycaemia.
Diabetic medicine : a journal of the British Diabetic Association
Diabet Med
39
2
10.1111/dme.14737
eng
2,022
2
null
2,021
11
16
[AIMS] This pragmatic review aimed to map and summarize the literature on model of care interventions to prevent inpatient hypoglycaemia. Model of care interventions were broadly defined as interventions that either directly target the workforce or where implementation had a strong workforce effect. The review intended...
diabetes mellitus; glycaemic control; hospital-acquired condition; hospitals; hypoglycaemia; prevention and control; review
1.246
171
Endocrinology; Endocrinology, Diabetes and Metabolism; Internal Medicine
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
34,741,107
Kernicterus Spectrum Disorders Diagnostic Toolkit: validation using retrospective chart review.
Pediatric research
Pediatr Res
91
4
10.1038/s41390-021-01755-5
eng
2,022
3
null
2,021
11
5
[BACKGROUND] Kernicterus Spectrum Disorders (KSDs) result from hyperbilirubinemia-induced brain injury. We developed a Toolkit (KSD-TK) to predict the likelihood of KSDs. This study aims to validate the KSD-TK by comparing it to clinical diagnoses made by the Kernicterus Clinic in the Division of Neurology. [METHODS] T...
null
1.04
176
Pediatrics, Perinatology and Child Health
Medicine
2,022
34,740,809
Altered diversity and composition of gut microbiota in patients with allergic rhinitis.
Microbial pathogenesis
Microb Pathog
161
Pt A
10.1016/j.micpath.2021.105272
eng
2,021
12
null
2,021
11
2
[BACKGROUND] Recently, multiple studies have suggested an association between gut dysbiosis and allergic rhinitis (AR) development. However, the role of gut microbiota in AR development remains obscure. [METHODS] The goal of this study was to compare the gut microbiota composition and short-chain fatty acid (SCFAs) dif...
Allergic rhinitis; Gut microbiota; SCFAS
0.693
107
Infectious Diseases; Microbiology
Immunology and Microbiology; Medicine
2,021
34,740,352
Determinants and levels of cervical Cancer screening uptake among women of reproductive age in South Africa: evidence from South Africa Demographic and health survey data, 2016.
BMC public health
BMC Public Health
21
1
10.1186/s12889-021-12020-z
eng
2,021
11
5
2,021
11
5
[BACKGROUND] Cervical cancer (CC) is the cancer with the most incidents and the leading cause of cancer mortality among women in South Africa. CC screening is one of the most cost-effective control approaches for the disease burden. This study assessed the determinants and individual-level indicators of cervical cancer...
Cervical cancer; Determinants; Levels; Reproductive age; Screening; South Africa; Women
1.156
211
Public Health, Environmental and Occupational Health
Medicine
2,021
34,740,149
Patient experience of the diagnosis and management of patellofemoral pain: A qualitative exploration.
Musculoskeletal science practice
Musculoskelet Sci Pract
57
null
10.1016/j.msksp.2021.102473
eng
2,022
2
null
2,021
10
28
[BACKGROUND] Patellofemoral pain (PFP) is common and long-term treatment outcomes are unsatisfactory. Qualitative exploration of diagnosis and management from the perspective of people with PFP is lacking. [OBJECTIVES] To inform care and improve intervention delivery by exploring the experience of people with PFP regar...
Diagnosis; Education; Management; Patellofemoral; Qualitative; Treatment
null
null
null
null
null
34,740,137
Temporal Validation of an Assessment Tool that Predicts a Possibility of Home Discharge for Patients with Acute Stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
J Stroke Cerebrovasc Dis
31
1
10.1016/j.jstrokecerebrovasdis.2021.106188
eng
2,022
1
null
2,021
11
2
[OBJECTIVES] Several prediction models have been developed to assess discharge destinations for patients with acute stroke; however, few studies have performed external validation. We aimed to perform a temporal external validation of a prediction tool to identify stroke patients with a high possibility of discharge to...
Clinical prediction rule; Patient discharge; Stroke; Stroke rehabilitation; Validation studies
0.713
85
Rehabilitation; Surgery; Cardiology and Cardiovascular Medicine; Neurology
Medicine
2,022
34,739,506
Longitudinal analysis of sociodemographic, clinical and therapeutic factors of HIV-infected individuals in Kinshasa at antiretroviral therapy initiation during 2006-2017.
PloS one
PLoS One
16
11
10.1371/journal.pone.0259073
eng
2,021
null
null
2,021
11
5
[BACKGROUND] The benefits of antiretroviral therapy (ART) underpin the recommendations for the early detection of HIV infection and ART initiation. Late initiation (LI) of antiretroviral therapy compromises the benefits of ART both individually and in the community. Indeed, it promotes the transmission of infection and...
null
0.852
467
Multidisciplinary
Multidisciplinary
2,021
34,739,136
Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility.
The Cochrane database of systematic reviews
Cochrane Database Syst Rev
11
11
10.1002/14651858.CD005356.pub3
eng
2,021
11
5
2,021
11
5
[BACKGROUND] Intrauterine insemination (IUI), combined with ovarian stimulation (OS), has been demonstrated to be an effective treatment for infertile couples. Several agents for ovarian stimulation, combined with IUI, have been proposed, but it is still not clear which agents for stimulation are the most effective. Th...
null
1.412
341
Medicine; Pharmacology
Medicine
2,021
34,738,677
DNA-Binding domain mutations confer severe outcome at an early age among STAT1 gain-of-function patients.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Pediatr Allergy Immunol
33
1
10.1111/pai.13694
eng
2,022
1
null
2,021
11
18
[BACKGROUND] STAT1 gain-of-function (GOF) is an immune dysregulatory disorder with poorly studied genotype-phenotype correlation, impeding prognostication and early intervention. Given previous mechanistic studies, as well as anecdotal clinical reports, we sought to systematically determine whether DNA-binding domain (...
DNA-binding domain; STAT1; gain-of-function; genotype; hematopoietic stem cell transplant; immune dysregulation; immunodeficiency; mortality; mutation
1.075
108
Pediatrics, Perinatology and Child Health; Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,022
34,738,091
Essentials for Standardising the Undergraduate Urology Curriculum in Europe: Outcomes of a Delphi Consensus from the European School of Urology.
European urology open science
Eur Urol Open Sci
33
null
10.1016/j.euros.2021.09.003
eng
2,021
11
null
2,021
9
28
[BACKGROUND] The burden of urological diseases is rising as the worldwide population ages. Although specialist urological provision is needed, a large proportion of these conditions will be managed in primary care. The importance of including urology in medical education currently remains unclear. [OBJECTIVE] To provid...
Delphi consensus; Education; Undergraduate medical education; Urology
0.353
41
Urology
Medicine
2,021
34,794,192
IDH Wild-type Glioblastoma Presenting with Seizure: Clinical Specificity, and Oncologic and Surgical Outcomes.
Journal of neurological surgery. Part A, Central European neurosurgery
J Neurol Surg A Cent Eur Neurosurg
83
4
10.1055/s-0041-1735515
eng
2,022
7
null
2,021
11
18
[BACKGROUND] Glioblastoma (GBM) is the most common and aggressive primary brain neoplasia in adults. Seizure is a common manifestation in GBM. Up to 25 to 60% of patients with GBM have seizures. We aim to summarize all the relevant clinical, surgical, radiologic, and molecular features of a cohort of patients suffering...
null
null
null
null
null
null
34,792,589
Development and Validation of a Deep Learning Model for Earlier Detection of Cognitive Decline From Clinical Notes in Electronic Health Records.
JAMA network open
JAMA Netw Open
4
11
10.1001/jamanetworkopen.2021.35174
eng
2,021
11
1
2,021
11
1
[IMPORTANCE] Detecting cognitive decline earlier among older adults can facilitate enrollment in clinical trials and early interventions. Clinical notes in longitudinal electronic health records (EHRs) provide opportunities to detect cognitive decline earlier than it is noted in structured EHR fields as formal diagnose...
null
4.031
154
Medicine
Medicine
2,021
34,792,283
Effects of school-based "We Fit" weight control programme in adolescents.
Nursing open
Nurs Open
9
1
10.1002/nop2.1125
eng
2,022
1
null
2,021
11
18
[AIM] This study examined the effects of a 12-week school-based "We Fit" weight control programme. [DESIGN] A nonequivalent control group was used, with a non-synchronized pretest-posttest design. [METHODS] In total, 109 Korean high school adolescents participated. The programme comprised exergaming, diet diary and cou...
active video game; adolescents; physical activity; school health; weight control
0.636
44
Nursing
Nursing
2,022
34,792,204
Mothers' high glycemic levels and the association between periodontitis and low birth weight.
Journal of periodontology
J Periodontol
93
7
10.1002/JPER.21-0406
eng
2,022
7
null
2,022
2
7
[BACKGROUND] Maternal hyperglycemia, periodontitis, and adverse gestational outcomes are important health problems. The present study investigated the hypothesis that periodontitis and the glycemic level of mothers may have opposing influences on birth weight (BW). This study evaluated the effect of high glycemic level...
epidemiology; glycated hemoglobin A; low birth weight infant; periodontal medicine; periodontitis; pregnancy
1.27
186
Periodontics
Dentistry
2,022
34,792,161
A randomized controlled trial of two dialysate sodium concentrations in hospitalized hemodialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Nephrol Dial Transplant
37
7
10.1093/ndt/gfab329
eng
2,022
6
23
null
null
null
[BACKGROUND] Several large dialysis organizations have lowered the dialysate sodium concentration (DNa) in an effort to ameliorate hypervolemia. The implications of lower DNa on intra-dialytic hypotension (IDH) during hospitalizations of hemodialysis (HD) patients is unclear. [METHODS] In this double-blind, single cent...
blood pressure; chronic hemodialysis; hemodialysis; hypotension; intradialytic hypotension
1.46
203
Medicine; Nephrology; Transplantation
Medicine
2,022
34,792,038
Performance of bone tracer for diagnosis and differentiation of transthyretin cardiac amyloidosis: a systematic review and meta-analysis.
Diagnostic and interventional radiology (Ankara, Turkey)
Diagn Interv Radiol
27
6
10.5152/dir.2021.20662
eng
2,021
11
null
null
null
null
[PURPOSE] Bone tracers have been validated for many years in detecting transthyretin cardiac amyloidosis (TTR-CA). However, several new studies suggest conflicting results. Our study aimed to systematically evaluate the accuracy of bone radiotracers for diagnosis and differentiation of TTR-CA via a systematic review an...
null
0.719
57
Cardiology and Cardiovascular Medicine; Radiology, Nuclear Medicine and Imaging
Medicine
2,021
34,791,958
Persistent sexual dysfunction after SSRI withdrawal: a scoping review and presentation of 86 cases from the Netherlands.
Expert opinion on drug safety
Expert Opin Drug Saf
21
4
10.1080/14740338.2022.2007883
eng
2,022
4
null
2,021
11
27
[BACKGROUND] Sexual dysfunction is highly prevalent worldwide. A specific form is persistent sexual dysfunction after SSRI withdrawal. We conducted a systematic literature review in order to characterize factors related to post SSRI sexual dysfunction (PSSD) and analyzed spontaneous reports of persistent sexual dysfunc...
PSSD; Persistent sexual dysfunction; SSRIs withdrawal; post SSRI sexual dysfunction
0.773
96
Medicine; Pharmacology
Medicine
2,022
34,791,951
Wellbeing and mental health amongst medical students in Canada.
The International journal of social psychiatry
Int J Soc Psychiatry
68
6
10.1177/00207640211057724
eng
2,022
9
null
2,021
11
18
[RESEARCH] There is abundant data revealing that there is significant rate of rates of Psychiatric morbidity, psychological stress, and burnout in the medical student population. A core study group in the UK collaborated with 12 countries around the world to review medical student wellness. In this context we surveyed ...
Canada; Medical students; wellbeing
1.984
86
Medicine; Psychiatry and Mental Health
Medicine
2,022
34,791,940
Reactivation of EBV and CMV in Severe COVID-19-Epiphenomena or Trigger of Hyperinflammation in Need of Treatment? A Large Case Series of Critically ill Patients.
Journal of intensive care medicine
J Intensive Care Med
37
9
10.1177/08850666211053990
eng
2,022
9
null
2,021
11
18
[BACKGROUND] Reactivation of viruses such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are common in critically ill patients and have been described in patients with severe COVID-19. However, it is unclear whether these reactivations are associated with increased mortality and whether targeted treatments are b...
ARDS; CMV; COVID-19; EBV; SARS-CoV-2; hyperinflammation; intensive care unit
1.039
75
Critical Care and Intensive Care Medicine
Medicine
2,022
34,791,718
Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis.
Addiction (Abingdon, England)
Addiction
117
6
10.1111/add.15742
eng
2,022
6
null
2,021
12
3
[BACKGROUND AND AIMS] CYP2B6, a genetically variable enzyme, converts bupropion to its active metabolite hydroxybupropion. CYP2B6 activity and bupropion-aided cessation differ between women and men. The aim of this study was to determine whether genetically normal (versus reduced) CYP2B6 activity increases bupropion-ai...
Bupropion; CYP2B6; hydroxybupropion; mediation analyses; pharmacogenetics; sex differences; smoking cessation
2.177
224
Medicine; Psychiatry and Mental Health
Medicine
2,022
34,791,655
Low-dose CT reconstruction with Noise2Noise network and testing-time fine-tuning.
Medical physics
Med Phys
48
12
10.1002/mp.15101
eng
2,021
12
null
2,021
11
17
[PURPOSE] Deep learning-based image denoising and reconstruction methods demonstrated promising performance on low-dose CT imaging in recent years. However, most existing deep learning-based low-dose CT reconstruction methods require normal-dose images for training. Sometimes such clean images do not exist such as for ...
Noise2Noise; computed tomography; deep learning; image reconstruction
1.174
218
Biophysics; Medicine; Radiology, Nuclear Medicine and Imaging
Biochemistry, Genetics and Molecular Biology; Medicine
2,021
34,791,551
Non-thermal plasma for surface treatment of inorganic fillers added to resin-based cements.
Clinical oral investigations
Clin Oral Investig
26
3
10.1007/s00784-021-04280-1
eng
2,022
3
null
2,021
11
18
[OBJECTIVES] This study aims to evaluate the effect of non-thermal plasma (NTP) surface treatment in two composite inorganic fillers and evaluate their impact on the chemical-mechanical properties and bond strength ability of experimental resin cements. [MATERIALS AND METHODS] Ytterbium fluoride (YF) and barium silicat...
Barium glass filling; Cold plasma; Resin cement; Silanes; Ytterbium fluoride
0.91
108
Dentistry
Dentistry
2,022
34,791,165
HeartMate 3: new challenges in ventricular tachycardia ablation.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Europace
24
4
10.1093/europace/euab272
eng
2,022
4
5
null
null
null
[AIM] To describe clinical characteristics, procedural details, specific challenges, and outcomes in patients with HeartMate3™ (HM3), a left ventricular assist device system with a magnetically levitated pump, undergoing ventricular tachycardia ablation (VTA). [METHODS AND RESULTS] Data were collected from patients wit...
Ablation; Left ventricular assist device; Ventricular tachycardia
null
null
null
null
null
34,790,815
Bioinformatic Analysis and Integration of Transcriptome and Proteome Results Identify Key Coding and Noncoding Genes Predicting Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas.
BioMed research international
Biomed Res Int
2021
null
10.1155/2021/1056622
eng
2,021
null
null
2,021
11
8
[BACKGROUND] Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma (PDAC). IPMNs are generally associated with high risk of developing malignancy and therefore need to be diagnosed and assessed accurately, once detected. Existing diagnostic methods are inadequate, an...
null
0.647
203
Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine
Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine
2,021
34,789,707
Prosthesis satisfaction and quality of life in US service members with combat-related major lower-limb amputation.
Prosthetics and orthotics international
Prosthet Orthot Int
46
1
10.1097/PXR.0000000000000054
eng
2,022
2
1
null
null
null
[BACKGROUND] Military amputee patient care programs offer extensive services, including advanced prosthetic devices, to restore function and improve quality of life (QOL) among veterans and service members with combat-related limb loss, but research on satisfaction with these devices is limited. [OBJECTIVE] To assess p...
null
0.477
66
Health Professions; Rehabilitation; Medicine
Health Professions; Medicine
2,022
34,789,665
The State of Point-of-Care Ultrasound Training in Undergraduate Medical Education: Findings From a National Survey.
Academic medicine : journal of the Association of American Medical Colleges
Acad Med
97
5
10.1097/ACM.0000000000004512
eng
2,022
5
1
2,022
4
27
[PURPOSE] The primary aim of this study was to evaluate the current state of point-of-care ultrasound (POCUS) integration in undergraduate medical education (UME) at MD-granting medical schools in the United States. [METHOD] In 2020, 154 clinical ultrasound directors and curricular deans at MD-granting medical schools ...
null
1.579
199
Education; Medicine
Medicine; Social Sciences
2,022
34,789,559
Dysregulation of prostaglandins, leukotrienes and lipoxin A4 in bronchiectasis.
Thorax
Thorax
77
10
10.1136/thoraxjnl-2020-216475
eng
2,022
10
null
2,021
11
17
[INTRODUCTION] Bronchiectasis is characterised by excessive neutrophilic inflammation. Lipid mediators such as prostaglandins and leukotrienes have crucial roles in the inflammatory response. Further characterisation of these lipids and understanding the interplay of anti-inflammatory and proinflammatory lipid mediator...
bronchiectasis; neutrophil biology
3.133
259
Pulmonary and Respiratory Medicine
Medicine
2,022
34,789,546
Real-World Effectiveness and Immunogenicity of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Patients on Hemodialysis.
Journal of the American Society of Nephrology : JASN
J Am Soc Nephrol
33
1
10.1681/ASN.2021060778
eng
2,022
1
null
2,021
11
17
[BACKGROUND] Patients on hemodialysis have an elevated risk for COVID-19 but were not included in efficacy trials of SARS-CoV-2 vaccines. [METHODS] We conducted a retrospective, observational study to estimate the real-world effectiveness and immunogenicity of two mRNA SARS-CoV-2 vaccines in a large, representative pop...
BNT162 vaccine; COVID-19; ESRD; RNA; SARS-CoV-2; coronavirus disease 2019; dialysis; end stage kidney disease; end-stage renal disease; messenger; vaccine
4.45
332
Medicine; Nephrology
Medicine
2,022
34,789,395
Response evaluation of locoregional therapies in combined hepatocellular-cholangiocarcinoma and intrahepatic cholangiocarcinoma versus hepatocellular carcinoma: a propensity score matched study.
Clinical radiology
Clin Radiol
77
2
10.1016/j.crad.2021.10.013
eng
2,022
2
null
2,021
11
14
[AIM] To evaluate the response of locoregional therapy (LRT) on combined hepatocellular-cholangiocarcinoma (cHCC-CC) and intrahepatic cholangiocarcinoma (IHC) and compare their outcomes with propensity matched hepatocellular carcinoma (HCC) patients. [MATERIALS AND METHODS] From January 2011 to July 2020, 13 patients w...
null
0.704
110
Medicine; Radiology, Nuclear Medicine and Imaging
Medicine
2,022
34,789,222
Public health implications of heavy metals in foods and drinking water in Ethiopia (2016 to 2020): systematic review.
BMC public health
BMC Public Health
21
1
10.1186/s12889-021-12189-3
eng
2,021
11
17
2,021
11
17
[BACKGROUND] Besides their benefits, heavy metals are toxic, persistent, and hazardous to human health, even at their lower concentrations. Consumption of unsafe concentrations of food contaminated with heavy metals may lead to the disruption of numerous biological and biochemical processes in the human body. In develo...
Drinking water; Ethiopia; Food safety; Health implication; Heavy metals; Public health
1.156
211
Public Health, Environmental and Occupational Health
Medicine
2,021
34,789,221
Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat.
BMC complementary medicine and therapies
BMC Complement Med Ther
21
1
10.1186/s12906-021-03455-3
eng
2,021
11
17
2,021
11
17
[BACKGROUND] Mucuna pruriens (L.) has been used for the treatment of several ailments in folkloric medicine. The present study therefore investigates the hepatoprotective and nephroprotective potentials of its leaves extract with a view to providing a potent alternative in the management of liver and kidney diseases. [...
Carbon tetrachloride; Mucuna pruriens; Oxidative stress; Rifampicin
0.674
123
Complementary and Alternative Medicine
Medicine
2,021
34,789,207
Cardiovascular diseases mortality and alcohol control policy in Lithuania: exploring a possible link.
BMC public health
BMC Public Health
21
1
10.1186/s12889-021-12177-7
eng
2,021
11
17
2,021
11
17
[BACKGROUND] Lithuania possesses one of the highest alcohol per capita consumption and has previously implemented alcohol control policies to reduce the alcohol-attributable burden. The aim of this study was to investigate Lithuanian cardiovascular disease (CVD) mortality rate trends between 2001 and 2018 and to explor...
Age; Alcohol consumption; Alcohol control policy; Cardiovascular diseases; Mortality; Sex; Trends
1.156
211
Public Health, Environmental and Occupational Health
Medicine
2,021
34,789,184
Determinants of the type of health care sought for symptoms of Acute respiratory infection in children: analysis of Ghana demographic and health surveys.
BMC pediatrics
BMC Pediatr
21
1
10.1186/s12887-021-02990-9
eng
2,021
11
17
2,021
11
17
[BACKGROUND] Globally, acute respiratory infection (ARI) is a leading cause of infant and childhood morbidity and mortality. Currently, it is estimated that 50 million cases of childhood ARI are untreated. In this study, we identified determinants of the type of treatment sought for symptoms of childhood acute respirat...
Acute respiratory infection (ARI); Bayesian spatial analysis; Care-seeking behavior; Demographic and Health Survey (GDHS); Ghana
0.676
106
Pediatrics, Perinatology and Child Health
Medicine
2,021
34,789,124
Recombinant Unique Cartilage Matrix-associated Protein Potentiates Osteogenic Differentiation and Mineralization of MC3T3-E1 Cells.
Current molecular medicine
Curr Mol Med
22
8
10.2174/1566524021666211117144314
eng
2,022
null
null
null
null
null
[OBJECTIVE] The relative balance of osteoblasts in bone formation and osteoclasts in bone resorption is crucial for maintaining bone health. With age, this balance between osteoblasts and osteoclasts is broken, resulting in bone loss. Anabolic drugs are continuously being developed to counteract this low bone mass. Rec...
GST-fusion; UCMA protein; differentiation; mineralization; osteoblast; recombinant
null
null
null
null
null
34,788,786
Time Preference for Immediate Gratification: Associations With Low Medication Adherence and Uncontrolled Blood Pressure.
American journal of hypertension
Am J Hypertens
35
3
10.1093/ajh/hpab175
eng
2,022
3
8
null
null
null
[BACKGROUND] In search of innovative approaches to the challenge of uncontrolled hypertension, we assessed the association between preference for immediate gratification (i.e., high discounting rate), low medication adherence, and uncontrolled blood pressure (BP) in adults with hypertension. [METHODS] Using a probabili...
blood pressure; hypertension; immediate vs. delayed gratification; medication adherence; temporal discounting; time preferences
0.879
156
Internal Medicine
Medicine
2,022
34,788,717
Relative Source Power: A novel method for localizing epileptiform EEG discharges.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Clin Neurophysiol
133
null
10.1016/j.clinph.2021.10.005
eng
2,022
1
null
2,021
10
29
[OBJECTIVE] To validate relative source power (RSP) imaging of extratemporal interictal epileptiform discharges (IEDs). [METHODS] The accuracy of RSP was validated in a cohort of patients with extratemporal focal epilepsy and a confined epileptogenic lesion (19 cm[3]) using distance to the lesion, concordance with rese...
EEG mapping; Epilepsy surgery; Extratemporal lesions; Interictal discharge; Source imaging; Source localization
1.212
230
Neurology; Neurology; Physiology; Sensory Systems
Medicine; Neuroscience
2,022
34,788,700
Meta-Analysis of the Crossed Versus Standard Limb Configuration in Endovascular Aneurysm Repair.
Annals of vascular surgery
Ann Vasc Surg
80
null
10.1016/j.avsg.2021.10.037
eng
2,022
3
null
2,021
11
14
[OBJECTIVE] To investigate whether the crossed-limb technique confers better or worse clinical outcomes compared to the standard straight limb configuration in standard endovascular aneurysm repair (EVAR). [METHODS] We conducted a systematic review to identify studies comparing outcomes of EVAR with the crossed versus ...
null
0.65
87
Cardiology and Cardiovascular Medicine; Medicine; Surgery
Medicine
2,022
34,788,280
Gender-related differences in prevalence, intensity and associated risk factors of Schistosoma infections in Africa: A systematic review and meta-analysis.
PLoS neglected tropical diseases
PLoS Negl Trop Dis
15
11
10.1371/journal.pntd.0009083
eng
2,021
11
null
2,021
11
17
[BACKGROUND] Schistosomiasis remains a global-health problem with over 90% of its burden concentrated in Africa. Field studies reflect the complex ways in which socio-cultural and socio-economic variables, affect the distribution of Schistosoma infections across different populations. This review set out to systematica...
null
1.45
172
Infectious Diseases; Pharmacology, Toxicology and Pharmaceutics; Public Health, Environmental and Occupational Health
Medicine; Pharmacology, Toxicology and Pharmaceutics
2,021
34,788,238
Referral Patterns of Central Retinal Artery Occlusion to an Academic Center Affiliated With a Stroke Center.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
J Neuroophthalmol
41
4
10.1097/WNO.0000000000001409
eng
2,021
12
1
null
null
null
[BACKGROUND] Central retinal artery occlusion (CRAO) is a medical emergency, and patients who present acutely should be immediately referred to the nearest stroke center. We evaluated practice patterns for CRAO management at one academic center over the last decade. [METHODS] This was a retrospective study on all adult...
null
0.731
74
Medicine; Neurology; Ophthalmology
Medicine
2,021
34,787,859
Real world results of venetoclax combined with hypomethylating agents in relapsed/refractory AML.
European review for medical and pharmacological sciences
Eur Rev Med Pharmacol Sci
25
21
10.26355/eurrev_202111_27126
eng
2,021
11
null
null
null
null
[OBJECTIVE] Relapsed/refractory AML cases are much more resistant to chemotherapy. Venetoclax is a highly sensitive BCL-2 inhibitor. It was aimed to evaluate the effects of venetoclax therapy on real-world R/R AML survival outcomes, the effects of the cytogenetic characteristics of the patients and previous clinical ap...
null
null
null
null
null
null
34,787,823
Pharmacokinetics, Pharmacodynamics, and Safety of Dulaglutide After Single or Multiple Doses in Chinese Healthy Subjects and Patients with T2DM: A Randomized, Placebo-Controlled, Phase I Study.
Advances in therapy
Adv Ther
39
1
10.1007/s12325-021-01921-5
eng
2,022
1
null
2,021
11
17
[INTRODUCTION] This study evaluated the pharmacokinetics, pharmacodynamics, and safety of a single dulaglutide dose in Chinese healthy subjects and of multiple dulaglutide doses in Chinese patients with type 2 diabetes mellitus (T2DM). [METHODS] This two-part, double-blind, placebo-controlled study included 16 healthy ...
Chinese participants; Dulaglutide
1.076
89
Medicine; Pharmacology
Medicine
2,022
34,787,691
The risk factors for Graves' ophthalmopathy.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Graefes Arch Clin Exp Ophthalmol
260
4
10.1007/s00417-021-05456-x
eng
2,022
4
null
2,021
11
17
[PURPOSE] This review aimed to provide an overview of current research into the risk factors for Graves' ophthalmopathy (GO). [METHODS] To find information about the risk factors for GO, the research database PubMed was searched and relevant articles were obtained to extract information about risk factors. [RESULTS] Sm...
Environment; Genetic codes; Human organism; Risk factor
null
null
null
null
null
34,787,551
Assessment and Diagnosis of Mental Illness in EDs Among Individuals Without a Home: Findings from the National Hospital Ambulatory Care Survey.
The western journal of emergency medicine
West J Emerg Med
22
6
10.5811/westjem.2021.7.51882
eng
2,021
11
5
2,021
11
5
[INTRODUCTION] Homeless individuals lack resources for primary healthcare and as a result use the emergency department (ED) as a social safety net. Our primary objective in this study was to identify the differences between features of visits to United States (US) EDs made by patients without a home and patients who li...
null
0.837
59
Emergency Medicine; Medicine
Medicine
2,021
34,787,296
Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review.
Sao Paulo medical journal = Revista paulista de medicina
Sao Paulo Med J
139
6
10.1590/1516-3180.2020.0766.R1.22042021
eng
2,021
null
null
2,021
11
15
[BACKGROUND] Rheumatic diseases (RDs) are a group of pathological conditions characterized by inflammation and functional disability. There is evidence suggesting that regular consumption of polyphenols has therapeutic effects capable of relieving RD symptoms. [OBJECTIVE] To synthesize data from randomized controlled t...
null
null
null
null
null
null
34,787,295
Colonization of methicillin-resistant Staphylococcus aureus among healthcare students: an integrative review.
Sao Paulo medical journal = Revista paulista de medicina
Sao Paulo Med J
139
6
10.1590/1516-3180.2020.0564.R2.22042021
eng
2,021
null
null
2,021
11
15
[BACKGROUND] Methicillin-resistant Staphylococcus aureus (MRSA) infection is a worldwide concern given its presence even in non-hospitalized healthy individuals, such as university students. [OBJECTIVE] To identify in the literature the prevalence of colonization by MRSA among healthcare students. [DESIGN AND SETTING] ...
null
null
null
null
null
null
34,787,004
Depression readmission risk is elevated in multiple sclerosis compared to other chronic illnesses.
Multiple sclerosis (Houndmills, Basingstoke, England)
Mult Scler
28
1
10.1177/13524585211051316
eng
2,022
1
null
2,021
11
17
[OBJECTIVE] Assess readmissions for depression or suicide attempt (SA) after MS admission versus other chronic inflammatory illnesses. [METHODS] This retrospective cohort study identified MS, asthma, rheumatoid arthritis (RA), depression, and SA in the 2013 National Readmissions Database by International Classification...
Multiple sclerosis; admissions; depression; outcome measurement; psychiatry
null
null
null
null
null
34,786,863
Aberrant salience in first-episode psychosis: Longitudinal stability and treatment-response.
Early intervention in psychiatry
Early Interv Psychiatry
16
8
10.1111/eip.13243
eng
2,022
8
null
2,021
11
16
[AIM] Aberrant salience (AS) is considered a putative predisposing factor for the onset of psychosis. However, despite several studies conducted in the general population, research in early psychosis is still relatively scarce. The main purposes of this study were to investigate any relevant correlation of AS with func...
aberrant salience; early detection; early intervention; early psychosis; first episode psychosis
1.037
62
Biological Psychiatry; Psychiatry and Mental Health
Medicine; Neuroscience
2,022
34,786,545
Telomere shortening in patients on long-term hemodialysis.
Chronic diseases and translational medicine
Chronic Dis Transl Med
7
4
10.1016/j.cdtm.2021.07.003
eng
2,021
12
null
2,021
8
25
[BACKGROUND] Leukocyte telomere length shortening is a characteristic of premature senescence, a process that can be accelerated by oxidative stress. In general, patients with end-stage renal disease undergoing regular hemodialysis (HD) are repeatedly exposed to oxidative stress. Patients undergoing HD tend to have car...
Cardiovascular disease; Chronic kidney disease; Hemodialysis; Hemoglobin; Telomere length
0.75
23
Medicine
Medicine
2,021
34,786,484
Novel open-source 3D-printed eye mount (TEMPO) for the ophthalmology wet lab.
BMJ open ophthalmology
BMJ Open Ophthalmol
6
1
10.1136/bmjophth-2020-000685
eng
2,021
null
null
2,021
11
10
[OBJECTIVE] Procuring an affordable eye mount that can stabilise a cadaveric eye and simulate a patient's normal facial contours represents an ongoing challenge in the ophthalmology simulation wet lab, with notable limitations to all currently available commercial options. This project uses computer-assisted design and...
eye (globe); eye (tissue) banking; medical education
1.067
28
Ophthalmology
Medicine
2,021
34,786,402
Choriocarcinoma misdiagnosed as cerebral hemangioma: A case report.
World journal of clinical cases
World J Clin Cases
9
30
10.12998/wjcc.v9.i30.9174
eng
2,021
10
26
null
null
null
[BACKGROUND] Choriocarcinoma is a subtype of gestational trophoblastic disease, gestational trophoblastic neoplasia. Patients with brain metastasis are rare and information on the optimal treatment and patient outcome is limited. In order to improve the prognosis of this disease, accurate and timely treatments are very...
Brain metastasis; Case report; Chemotherapy; Choriocarcinoma; Craniotomy; Uterine artery embolization; Whole brain radiotherapy
0.38
38
Medicine
Medicine
2,021
34,786,387
"An integrated system, three separated responsibilities", a new fever clinic management model, in prevention and control of novel coronavirus pneumonia.
World journal of clinical cases
World J Clin Cases
9
30
10.12998/wjcc.v9.i30.9050
eng
2,021
10
26
null
null
null
[BACKGROUND] Since December 2019, there have been many new cases of coronavirus pneumonia in Wuhan, Hubei Province, which has gradually spread throughout the country. [AIM] To explore our hospital's innovative management system to ensure the efficient operation of fever clinics during the epidemic, since controlling th...
Epidemic prevention and control; Fever clinics; Integration of three responsibilities; Novel coronavirus; Novel coronavirus pneumonia
0.38
38
Medicine
Medicine
2,021
34,786,176
Machine learning models for predicting non-alcoholic fatty liver disease in the general United States population: NHANES database.
World journal of hepatology
World J Hepatol
13
10
10.4254/wjh.v13.i10.1417
eng
2,021
10
27
null
null
null
[BACKGROUND] Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting over 30% of the United States population. Early patient identification using a simple method is highly desirable. [AIM] To create machine learning models for predicting NAFLD in the general United States populatio...
Artificial intelligence; Fatty liver; Machine learning; NHANES; Non-alcoholic fatty liver disease; United States population
null
null
null
null
null
34,785,935
Association of Admission Blood Glucose Level with All-Cause Mortality According to Age in Patients with Community Acquired Pneumonia.
International journal of general medicine
Int J Gen Med
14
null
10.2147/IJGM.S331082
eng
2,021
null
null
2,021
11
6
[OBJECTIVE] To assess the impact of blood glucose levels on the prognosis of patients with community-acquired pneumonia (CAP) who were elderly or middle-aged. [METHODS] From January 1, 2018, to December 31, 2020, patients with CAP (≥45 years) were retrospectively enrolled in this observational study. They were stratifi...
age; community-acquired pneumonia; hyperglycemia; mortality; prognosis
null
null
null
null
null
34,785,888
Exploring the Underlying Mechanism of Shenyankangfu Tablet in the Treatment of Glomerulonephritis Through Network Pharmacology, Machine Learning, Molecular Docking, and Experimental Validation.
Drug design, development and therapy
Drug Des Devel Ther
15
null
10.2147/DDDT.S333209
eng
2,021
null
null
2,021
11
9
[PURPOSE] This study aimed to explore the underlying mechanisms of Shenyankangfu tablet (SYKFT) in the treatment of glomerulonephritis (GN) based on network pharmacology, machine learning, molecular docking, and experimental validation. [METHODS] The active ingredients and potential targets of SYKFT were obtained throu...
glomerulonephritis; machine learning; molecular docking; network pharmacology; shenyankangfu tablet
0.784
108
Pharmaceutical Science; Drug Discovery; Pharmacology
Pharmacology, Toxicology and Pharmaceutics
2,021
34,785,427
Associations of adipokine levels with the prevalence and extent of valvular and thoracic aortic calcification: The Multi-Ethnic Study of Atherosclerosis (MESA).
Atherosclerosis
Atherosclerosis
338
null
10.1016/j.atherosclerosis.2021.11.002
eng
2,021
12
null
2,021
11
5
[BACKGROUND AND AIMS] Extra-coronary calcification (ECC) is a marker of atherosclerosis and independently associated with cardiovascular disease (CVD). Adipokines may mediate the effect of obesity on atherosclerosis. However, the relationship of adipokines with ECC is not well-established. We examined the associations ...
Adipokines; Atherosclerosis; Epidemiology; Obesity; Risk factors; Thoracic calcium; Valvular calcium
1.399
201
Cardiology and Cardiovascular Medicine
Medicine
2,021
34,785,393
HIV-1 drug resistance in adults and adolescents on protease inhibitor-based antiretroviral therapy in KwaZulu-Natal Province, South Africa.
Journal of global antimicrobial resistance
J Glob Antimicrob Resist
29
null
10.1016/j.jgar.2021.10.023
eng
2,022
6
null
2,021
11
14
[OBJECTIVES] In low-middle-income countries, increasing levels of HIV drug resistance (HIVDR) on second-line protease inhibitor (PI)-based regimens are a cause for concern given the limited drug options for third-line antiretroviral therapy (ART). We conducted a retrospective analysis of routine HIV-1 genotyping labora...
Adults and adolescents; Antiretroviral therapy; Drug resistance; HIV-1; Protease inhibitor; Third-line ART
0.879
55
Immunology; Immunology and Allergy; Microbiology; Microbiology
Immunology and Microbiology; Medicine
2,022
34,785,107
Agrimoniin sensitizes pancreatic cancer to apoptosis through ROS-mediated energy metabolism dysfunction.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Phytomedicine
96
null
10.1016/j.phymed.2021.153807
eng
2,022
2
null
2,021
10
19
[BACKGROUND] Pancreatic cancer is a fatal tumor, which is one of the most common malignant tumors at present. Patients with pancreatic cancer also respond poorly to chemotherapy or radiation therapy and may be accompanied by serious adverse reactions. Therefore, to find an effective way to inhibit the initiation and pr...
Agrimoniin; Energy metabolism; Pancreatic cancer; ROS
1.126
150
Complementary and Alternative Medicine; Drug Discovery; Pharmaceutical Science; Pharmacology; Molecular Medicine
Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics
2,022
34,785,075
Cancer survival prognosis with Deep Bayesian Perturbation Cox Network.
Computers in biology and medicine
Comput Biol Med
141
null
10.1016/j.compbiomed.2021.105012
eng
2,022
2
null
2,021
11
2
[BACKGROUND] The Cox proportional hazards model with neural networks is widely used to accurately predict survival outcome for choosing cancer treatment strategies. Although this method has shown outstanding performance in many tasks, it has encountered challenges when dealing with high-dimensional datasets. In this st...
Bayesian estimation; Censored data; Cox proportional hazards; Deep learning; Survival analysis
1.222
142
Computer Science Applications; Health Informatics
Computer Science; Medicine
2,022
34,784,964
Successful induction treatment of bullous pemphigoid using reslizumab: a case report.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Allergy Asthma Clin Immunol
17
1
10.1186/s13223-021-00619-1
eng
2,021
11
16
2,021
11
16
[BACKGROUND] Bullous pemphigoid (BP) is a potentially life-threatening autoimmune blistering disease which is characterized by autoantibodies against hemidesmosomal proteins of the skin and mucous membranes. In recent years, the role of eosinophil and immunoglobulin E autoantibodies have been further elucidated in BP, ...
Bullous pemphigoid; Corticosteroid; Eosinophil; Reslizumab
0.711
56
Pulmonary and Respiratory Medicine; Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,021
34,784,651
Youth use of e-liquid flavours-a systematic review exploring patterns of use of e-liquid flavours and associations with continued vaping, tobacco smoking uptake or cessation.
Addiction (Abingdon, England)
Addiction
117
5
10.1111/add.15723
eng
2,022
5
null
2,021
11
22
[BACKGROUND AND AIMS] There is concern that young people may be attracted to e-liquid flavours, prompting long-term vaping in naive users and potentially subsequent tobacco smoking. We aimed to review the use of e-liquid flavours by young people and describe associations with uptake or cessation of both regular vaping ...
E-cigarettes; flavours; harm reduction; smoking cessation; smoking uptake or continuation; systematic review; young people
2.177
224
Medicine; Psychiatry and Mental Health
Medicine
2,022
34,784,619
Potentially Preventable Primary Cesarean Sections in Future Placenta Accreta Spectrum.
American journal of perinatology
Am J Perinatol
39
2
10.1055/s-0041-1739493
eng
2,022
1
null
2,021
11
16
[OBJECTIVE] Prior cesarean delivery is a well-known risk factor for placenta accreta spectrum disorders. While primary cesarean section is unavoidable in some patients, in others it may not be clearly indicated. The aim of the study is to determine the proportion of patients with placenta accreta spectrum who had a pot...
null
0.732
87
Obstetrics and Gynecology; Pediatrics, Perinatology and Child Health
Medicine
2,022
34,784,590
Cytological Screening Model of Normal Oral Mucosa Exposed to Carcinogens: A Pilot Study.
Acta cytologica
Acta Cytol
66
2
10.1159/000519877
eng
2,022
null
null
2,021
11
16
[INTRODUCTION] Oral cytopathology is able to detect incipient cellular alterations, but it is not routinely applied to this purpose. We aimed to establish a model to screen individuals with no oral lesion exposed to smoking/alcohol, by means of the nuclear area, cell proliferation rate, and analysis of genetic damage. ...
Argyrophilic nucleolar organizer regions; Exfoliative cytology; Oral cancer; Prevention; Tobacco
0.733
67
Histology; Medicine; Pathology and Forensic Medicine
Medicine
2,022
34,784,567
Parental perceptions towards childhood stuttering in Sri Lanka.
Journal of communication disorders
J Commun Disord
95
null
10.1016/j.jcomdis.2021.106162
eng
2,022
null
null
2,021
11
4
[INTRODUCTION] Parental perceptions towards stuttering is an important consideration as parents play a crucial role in the initial identification and management of stuttering in young children. Although several studies have been conducted on parental perceptions towards childhood stuttering in other countries, little i...
Childhood stuttering; Parental perceptions; Qualitative; Sri lanka
0.669
79
Linguistics and Language; LPN and LVN; Experimental and Cognitive Psychology; Speech and Hearing; Cognitive Neuroscience
Health Professions; Neuroscience; Nursing; Psychology; Social Sciences
2,022
34,783,912
Could the socket shield technique be better than conventional immediate implantation? A meta-analysis.
Clinical oral investigations
Clin Oral Investig
26
2
10.1007/s00784-021-04266-z
eng
2,022
2
null
2,021
11
16
[OBJECTIVES] The purpose of this study was to evaluate whether the clinical outcome of socket shield technique (SST) is superior to that of conventional immediate implantation (CII). [MATERIALS AND METHOD] Five electronic databases (PubMed, Cochrane, Web of Science, CNKI, and Google Scholar) were searched to identify r...
Immediate implantation; Labial bone resorption; Pink esthetic; Socket shield
0.91
108
Dentistry
Dentistry
2,022
34,783,397
Psychosocial characteristics of patients evaluated for kidney transplant and associations with functional and frailty metrics at a veterans affairs hospital.
Clinical transplantation
Clin Transplant
36
2
10.1111/ctr.14530
eng
2,022
2
null
2,021
11
29
[BACKGROUND] The effect of psychosocial problems on listing outcomes and potential interactions with functional metrics is not well-characterized among Veteran transplant candidates. [METHODS] The results from psychosocial evaluations, frailty metrics, and biochemical markers were collected on 375 consecutive Veteran k...
depression; frailty; kidney transplant evaluation; listing outcomes; models; nonadherence; pedometer; psychosocial; treadmill; up-and-go
0.842
90
Transplantation
Medicine
2,022
34,783,210
A novel gene signature associated with poor response to chemoradiotherapy in patients with locally advanced cervical cancer.
Journal of gynecologic oncology
J Gynecol Oncol
33
1
10.3802/jgo.2022.33.e7
eng
2,022
1
null
2,021
10
18
[OBJECTIVE] We aimed to investigate the distinct transcriptional landscape in poor responders to concurrent chemoradiotherapy (CCRT) and to gain mechanistic insights into treatment resistance in cervical cancer. [METHODS] RNA sequencing was performed in patients with locally advanced cervical cancer treated with platin...
Cancer-associated Fibroblasts; Cervical Cancer; Chemoradiotherapy; Gene Signature
0.922
56
Medicine; Obstetrics and Gynecology; Oncology
Medicine
2,022
34,783,205
Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling.
Journal of gynecologic oncology
J Gynecol Oncol
33
1
10.3802/jgo.2022.33.e2
eng
2,022
1
null
2,021
10
25
[OBJECTIVE] Endometrial cancer (ECa) is a common gynecological malignancy. Circular RNAs (circRNAs) have been identified as key regulators of human tumorigenesis and development. Herein, we explored the role and mechanism of circular RNA intraflagellar transport 80 (circ-IFT80, also called circ_0067835) in ECa. [METHOD...
Circular RNA Intraflagellar Transport 80; Endometrial Cancer; MicroRNA; Tumor Progression
0.922
56
Medicine; Obstetrics and Gynecology; Oncology
Medicine
2,022
34,782,172
Free flap for lower limb salvage in infectious purpura fulminans.
Annales de chirurgie plastique et esthetique
Ann Chir Plast Esthet
66
6
10.1016/j.anplas.2021.10.001
eng
2,021
12
null
2,021
11
12
[BACKGROUND] Infectious purpura fulminans is a disabling disease often leading to amputations. Free flaps preserve limb length, covering exposed areas. We examined the efficacy of free flaps for lower limb salvage in infectious purpura fulminans survivors by evaluating surgical management, walking ability and quality o...
Free flap; Lambeau libre; Limb salvage; Purpura fulminans; Quality of life; Sauvetage de membre
null
null
null
null
null
34,782,065
Circulating C-reactive protein levels in patients with suspected obstructive sleep apnea.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
J Clin Sleep Med
18
4
10.5664/jcsm.9774
eng
2,022
4
1
null
null
null
[STUDY OBJECTIVES] To assess determinants of C-reactive protein (CRP) in a cohort of patients referred for investigation of obstructive sleep apnea (OSA) and to determine whether the overlap of OSA and chronic obstructive pulmonary disease (overlap syndrome) is associated with higher levels of CRP. [METHODS] This was a...
CRP; obstructive sleep apnea; polysomnography; spirometry; systemic inflammation
0.988
129
Neurology; Neurology; Pulmonary and Respiratory Medicine
Medicine; Neuroscience
2,022
34,782,009
A comparative analysis of L1 retrotransposition activities in human genomes suggests an ongoing increase in L1 number despite an evolutionary trend towards lower activity.
Mobile DNA
Mob DNA
12
1
10.1186/s13100-021-00255-x
eng
2,021
11
15
2,021
11
15
[BACKGROUND] LINE-1 (Long Interspersed Nuclear Elements, L1) retrotransposons are the only autonomously active transposable elements in the human genome. The evolution of L1 retrotransposition rates and its implications for L1 dynamics are poorly understood. Retrotransposition rates are commonly measured in cell cultur...
null
null
null
null
null
null