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35,940,559
[Translated article] Transcultural validation and adaptation of the Pedi-IKDC scale for the functional assessment of children that undergo knee surgery.
Revista espanola de cirugia ortopedica y traumatologia
Rev Esp Cir Ortop Traumatol
66
6
10.1016/j.recot.2022.08.001
eng
2,022
null
null
2,022
8
6
[INTRODUCTION] In the last decades sports practice in children has increased, thus increasing the number of musculoskeletal injuries. There are no validated scales in Spanish for the functional evaluation of knee aspects in children. The validation and cross-cultural adaptation of the Pedi-IKDC scale to Spanish, used f...
Children; Eminencia tibial; Escala; Knee; Rodilla; Scale; Tibial eminence
0.274
20
Orthopedics and Sports Medicine; Surgery
Medicine
2,022
35,940,344
Flavonoid-containing supplements for preventing acute respiratory tract infections: A systematic review and meta-analysis of 20 randomized controlled trials.
Complementary therapies in medicine
Complement Ther Med
70
null
10.1016/j.ctim.2022.102865
eng
2,022
11
null
2,022
8
5
[BACKGROUND] This systematic review and meta-analysis was conducted to investigate the efficacy and safety of flavonoid-containing supplements in preventing acute respiratory tract infection (ARTI). [METHODS] Randomized controlled trials (RCTs) investigating the effects of flavonoid-containing supplements on ARTI preve...
Acute respiratory tract infection; Flavonoid; Meta-analysis; Systematic review
0.652
86
Advanced and Specialized Nursing; Complementary and Alternative Medicine; Complementary and Manual Therapy
Health Professions; Medicine; Nursing
2,022
35,940,302
Predicting misdiagnosed adult-onset type 1 diabetes using machine learning.
Diabetes research and clinical practice
Diabetes Res Clin Pract
191
null
10.1016/j.diabres.2022.110029
eng
2,022
9
null
2,022
8
5
[AIMS] It is now understood that almost half of newly diagnosed cases of type 1 diabetes are adult-onset. However, type 1 and type 2 diabetes are difficult to initially distinguish clinically in adults, potentially leading to ineffective care. In this study a machine learning model was developed to identify type 1 diab...
AI; Adult-onset type 1 diabetes; Clinical decision support tool; Machine learning; Misdiagnosis; Predictive algorithm
1.634
146
Endocrinology; Endocrinology, Diabetes and Metabolism; Internal Medicine; Medicine
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,939,987
Indocyanine green fluorescence-guided surgery in head and neck cancer: A systematic review.
American journal of otolaryngology
Am J Otolaryngol
43
5
10.1016/j.amjoto.2022.103570
eng
2,022
null
null
2,022
8
2
[OBJECTIVE] To assess the feasibility and effectiveness of indocyanine green (ICG) for image-guided resection of head and neck cancer (HNC). [DATA SOURCES] PubMed, Embase, and Scopus databases. [REVIEW METHODS] Searches were conducted from database inception to February 2022. Patient and study characteristics, imaging ...
Fluorescence-guided surgery; Head and neck cancer; Indocyanine green (ICG); Intraoperative imaging; Near-infrared fluorescence imaging
null
null
null
null
null
35,939,628
Switching from standard to extended half-life FVIII prophylaxis in haemophilia A: Comparison of factor product use, bleed rates and pharmacokinetics.
Haemophilia : the official journal of the World Federation of Hemophilia
Haemophilia
28
6
10.1111/hae.14649
eng
2,022
11
null
2,022
8
8
[INTRODUCTION] Majority of haemophilia A patients in our comprehensive care centre have switched from standard half-life (SHL) to extended half-life (EHL) FVIII products in a short time. [AIM] We compared the clinical and laboratory outcomes between SHL and EHL FVIII prophylaxis in product switchers. [METHODS] This is ...
annualized bleed rate; extended half-life; factor FVIII deficiency; haemophilia A; prophylaxis
1.145
107
Hematology; Medicine; Genetics
Medicine
2,022
35,939,577
Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults.
The New England journal of medicine
N Engl J Med
387
4
10.1056/NEJMoa2202106
eng
2,022
7
28
null
null
null
[BACKGROUND] Vitamin D supplements are widely recommended for bone health in the general population, but data on whether they prevent fractures have been inconsistent. [METHODS] In an ancillary study of the Vitamin D and Omega-3 Trial (VITAL), we tested whether supplemental vitamin D3 would result in a lower risk of fr...
null
26.015
1,231
Medicine
Medicine
2,022
35,939,340
Serial neurocognitive changes following transcatheter aortic valve replacement: comparison between low and intermediate-high risk groups.
Aging
Aging (Albany NY)
14
15
10.18632/aging.204202
eng
2,022
8
5
2,022
8
5
[BACKGROUND] Data comparing the neurocognitive trajectory between low and intermediate-high risk patients following transcatheter aortic valve replacement (TAVR) is never reported. [AIMS] To report serial neurocognitive changes up to 1 year post-TAVR in low and intermediate-high risk groups as well as overall cohort. [...
TAVR; aortic stenosis; neurocognitive function
1.2
132
Aging; Cell Biology
Biochemistry, Genetics and Molecular Biology
2,022
35,939,332
Efficacy of ablation index-guided pulmonary vein isolation in patients with paroxysmal atrial fibrillation.
Pacing and clinical electrophysiology : PACE
Pacing Clin Electrophysiol
45
10
10.1111/pace.14578
eng
2,022
10
null
2,022
9
1
[BACKGROUND] Ablation index (AI) is a novel technology of ablation lesion quality to help improve homogeneity of lesion size and continuity. In this study, we aim to evaluate whether AI-guided PVI improves clinical outcomes compared to CF-guided PVI in patients with paroxysmal AF (PAF). [METHODS] Patients undergoing fi...
ablation index; atrial fibrillation; catheter ablation; contact force; radiofrequency ablation
null
null
null
null
null
35,991,671
Treatment with β-blocker nebivolol ameliorates oxidative stress and endothelial dysfunction in tenofovir-induced nephrotoxicity in rats.
Frontiers in medicine
Front Med (Lausanne)
9
null
10.3389/fmed.2022.953749
eng
2,022
null
null
2,022
8
4
[BACKGROUND] Tenofovir disoproxil fumarate (TDF), a widely prescribed component in antiretroviral regimens, has been associated with nephrotoxicity. Nebivolol is a third generation selective β-1 adrenergic receptor blocker and may protect renal structure and function through the suppression of oxidative stress and enha...
endothelium dysfunction; hypertension; nebivolol; nephrotoxicity; oxidative stress; tenofovir
0.926
102
Medicine
Medicine
2,022
35,991,360
Addition of 2 mg dexamethasone to improve the anesthetic efficacy of 2% lidocaine with 1:80,000 epinephrine administered for inferior alveolar nerve block to patients with symptomatic irreversible pulpitis in the mandibular molars: a randomized double-blind clinical trial.
Journal of dental anesthesia and pain medicine
J Dent Anesth Pain Med
22
4
10.17245/jdapm.2022.22.4.305
eng
2,022
8
null
2,022
7
26
[INTRODUCTION] This clinical trial aimed to evaluate the anesthetic effect of the addition of 2 mg (4 mg/ml) of dexamethasone to 2% lidocaine (plain or with 1:80,000 epinephrine). The solutions were injected for a primary inferior alveolar nerve block (IANB) to provide mandibular anesthesia for the endodontic treatment...
Anesthesia; Dexamethasone; Irreversible Pulpitis; Lidocaine; Mandible
null
null
null
null
null
35,991,341
Comparison of treatment outcome definitions in drug-resistant tuberculosis patients with high incidence of acquired second-line drug resistance.
African journal of thoracic and critical care medicine
Afr J Thorac Crit Care Med
28
2
10.7196/AJTCCM.2022.v28i2.177
eng
2,022
null
null
2,022
7
15
[BACKGROUND] Simplified drug-resistant tuberculosis (DR-TB) treatment outcome definitions, mostly centred around receipt of treatment and sputum culture status at 6 months after treatment initiation, have been proposed, but have not been widely evaluated in resource-limited settings. [OBJECTIVES] To compare DR-TB treat...
DR-TB treatment outcome; Drug resistant tuberculosis
null
null
null
null
null
35,991,246
Effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for CABG.
Pakistan journal of medical sciences
Pak J Med Sci
38
6
10.12669/pjms.38.6.5518
eng
2,022
null
null
null
null
null
[OBJECTIVE] To investigate the efficacy of perioperative administration of a single dose of gabapentin on postoperative pain in patients undergoing sternotomy for CABG. [METHODS] A cross-sectional analytical study was conducted at the cardiology ward of Ch. Pervaiz Elahi Institute of Cardiology, Multan, form 9[th] June...
CABG; Gabapentin; Outcomes; Post-surgical pain; Sternotomy
null
null
null
null
null
35,990,942
Developing a Hybrid Risk Assessment Tool for Familial Hypercholesterolemia: A Machine Learning Study of Chinese Arteriosclerotic Cardiovascular Disease Patients.
Frontiers in cardiovascular medicine
Front Cardiovasc Med
9
null
10.3389/fcvm.2022.893986
eng
2,022
null
null
2,022
8
3
[BACKGROUND] Familial hypercholesterolemia (FH) is an autosomal-dominant genetic disorder with a high risk of premature arteriosclerotic cardiovascular disease (ASCVD). There are many alternative risk assessment tools, for example, DLCN, although their sensitivity and specificity vary among specific populations. We aim...
DLCN; early detection and prevention; familial hypercholesterolemia (FH); hybrid diagnosis; risk assessment
1.391
81
Cardiology and Cardiovascular Medicine
Medicine
2,022
35,990,788
Non-alcoholic fatty liver disease (NAFLD) in Filipino North American patients: Results from a multi-ethnic cohort.
Canadian liver journal
Can Liver J
5
1
10.3138/canlivj-2021-0025
eng
2,022
null
null
2,022
2
4
[BACKGROUND] Non-alcoholic fatty liver disease (NAFLD) is more prevalent in certain ethnicities due to a combination of genetic, environmental, and metabolic factors. North American Filipino populations may have lifestyle and metabolic risk factors for NAFLD; however, the prevalence of NAFLD in this group is unknown. W...
Filipino; cirrhosis; ethnicity; fibrosis; non-alcoholic fatty liver disease
null
null
null
null
null
35,990,084
Duration of the effectiveness of nicotine electronic cigarettes on smoking cessation and reduction: Systematic review and meta-analysis.
Frontiers in psychiatry
Front Psychiatry
13
null
10.3389/fpsyt.2022.915946
eng
2,022
null
null
2,022
8
4
[BACKGROUND] The success of pharmacotherapies for smoking cessation in real-life remains limited, with a significant number of long-term relapses. Despite first promising results, the duration of the effectiveness of electronic cigarettes is still unknown. Our objective was to assess the duration of the effectiveness o...
Electronic Nicotine Delivery Systems (ENDS); electronic cigarettes (E-cigarettes); serious adverse effects; smoking cessation; smoking reduction
1.222
134
Psychiatry and Mental Health
Medicine
2,022
35,989,519
Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb.
Movement disorders : official journal of the Movement Disorder Society
Mov Disord
37
10
10.1002/mds.29161
eng
2,022
10
null
2,022
8
21
[BACKGROUND] Lewy body diseases (LBDs), which are pathologically defined as the presence of intraneuronal α-synuclein (α-Syn) inclusions called Lewy bodies, encompass Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies. Autopsy studies have shown that the olfactory bulb (OB) is one of ...
olfactory bulb; primate
2.602
238
Neurology; Neurology
Medicine; Neuroscience
2,022
35,989,399
2-Mercaptoethanol protects against DNA double-strand breaks after kidney ischemia and reperfusion injury through GPX4 upregulation.
Pharmacological reports : PR
Pharmacol Rep
74
5
10.1007/s43440-022-00403-x
eng
2,022
10
null
2,022
8
22
[BACKGROUND] Kidney ischemia reperfusion injury (IRI) is characterized by tubular cell death. DNA double-strand breaks is one of the major sources of tubular cell death induced by IRI. 2-Mercaptoethanol (2-ME) is protective against DNA double-strand breaks derived from calf thymus and bovine embryo. Here, we sought to ...
2-Mercaptoethanol; Ataxia telangiectasia mutated; DNA damage response; Glutathione peroxidase 4; H2A.X variant histone; Ischemia and reperfusion injury
0.802
100
Medicine; Pharmacology
Medicine; Pharmacology, Toxicology and Pharmaceutics
2,022
35,989,266
Health check attendance association with health and study-related factors: a register-based cohort study of Finnish university entrants.
Environmental health and preventive medicine
Environ Health Prev Med
27
null
10.1265/ehpm.22-00032
eng
2,022
null
null
null
null
null
[BACKGROUND] General health checks are an established component of preventive health care in many countries. Declining participation rates have raised concerns in health care providers. Understanding the reasons for attendance and non-attendance is necessary to improve the preventive health care system. The aim of this...
Health behavior; Health check; Health promotion; Health services research; Student health care
0.996
64
Medicine; Public Health, Environmental and Occupational Health
Medicine
2,022
35,988,882
Prevalence of bovine rotavirus among cattle in mainland China: A meta-analysis.
Microbial pathogenesis
Microb Pathog
170
null
10.1016/j.micpath.2022.105727
eng
2,022
9
null
2,022
8
19
[BACKGROUND] Bovine rotavirus is the primary pathogen causing diarrhea in cattle and can be transmitted vertically through the placenta. It mainly presents with clinical signs such as depression, loss of appetite, diarrhea, vomiting, and dehydration. [METHODS] A systematic review and meta-analysis were conducted to ass...
Bovine rotavirus; China; Epidemiology; Systematic review
0.716
107
Infectious Diseases; Microbiology
Immunology and Microbiology; Medicine
2,022
35,988,397
Facial involvement in multiple sclerosis.
Multiple sclerosis and related disorders
Mult Scler Relat Disord
67
null
10.1016/j.msard.2022.104110
eng
2,022
11
null
2,022
8
13
[BACKGROUND] Multiple sclerosis (MS) can present with facial symptoms and signs, such as facial palsy, myokymia, and hemifacial spasm. Considering the importance of early diagnosis, treatment, and exclusion of causes other than MS, we aimed to assess the prevalence of these disorders in patients with MS. [METHODS] MS p...
Facial palsy; Hemifacial palsy; Multiple sclerosis; Myokymia
0.92
70
Medicine; Neurology; Neurology
Medicine; Neuroscience
2,022
35,988,395
Application of DCE-US using the LI-RADS for patients with liver nodules at high risk for hepatocellular carcinoma: A preliminary study and comparison with visual interpretation.
European journal of radiology
Eur J Radiol
155
null
10.1016/j.ejrad.2022.110473
eng
2,022
10
null
2,022
8
12
[OBJECTIVE] To explore the value of dynamic contrast-enhanced ultrasound (DCE-US) for the Liver Imaging Reporting and Data System (LI-RADS). [METHODS] We included 220 liver nodules at high risk for hepatocellular carcinoma (HCC) from January 2019 to October 2021. Visual interpretation and DCE-US-based quantitative cate...
Dynamic contrast-enhanced ultrasound (DCE-US); Hepatocellular carcinoma; Liver imaging reporting and data system; Ultrasound
0.939
139
Medicine; Radiology, Nuclear Medicine and Imaging
Medicine
2,022
35,988,367
Efficacy of tranexamic acid (TXA) for post-tonsillectomy hemorrhage.
American journal of otolaryngology
Am J Otolaryngol
43
5
10.1016/j.amjoto.2022.103582
eng
2,022
null
null
2,022
8
6
[PURPOSE] To determine if tranexamic acid (TXA) reduces the need for operative re-cauterization in the setting of a post-tonsillectomy hemorrhage (PTH). [METHODS] A retrospective chart review was performed on 1428 adult and pediatric patients who underwent tonsillectomy over a two-year period at a tertiary care hospita...
Post-tonsillectomy hemorrhage; Tonsillar hemorrhage; Tonsillectomy; Tranexamic acid
null
null
null
null
null
35,988,229
Observation of the effect of arthroscopically assisted percutaneous minimally invasive Kirschner wire tension band fixation on the treatment of patellar fractures.
Technology and health care : official journal of the European Society for Engineering and Medicine
Technol Health Care
31
1
10.3233/THC-220133
eng
2,023
null
null
null
null
null
[BACKGROUND] Patellar fractures are common intra-articular fractures. Arthroscopically assisted reduction and fixation has been shown to advantageous in the treatment of patellar fractures. [OBJECTIVE] This study aimed to investigate the effect of arthroscopically assisted percutaneous minimally invasive Kirschner wire...
Patellar fracture; arthroscopy; internal fixation; percutaneous; tension band
null
null
null
null
null
35,988,134
Examining the relationship between dysmorphia symptoms and suicidality through the lens of the Interpersonal Theory of Suicide.
Journal of clinical psychology
J Clin Psychol
79
2
10.1002/jclp.23433
eng
2,023
2
null
2,022
8
21
[OBJECTIVE] Using the Interpersonal Theory of Suicide (IPTS) as a framework, this two-study investigation tested whether burdensomeness and low belongingness explained the association between body and muscle dysmorphia symptoms and suicidal ideation (tested in Study 1 and Study 2), and if fearlessness about death and p...
Interpersonal Theory of Suicide; body dysmorphic disorder; muscle dysmorphia; suicidal ideation; suicide attempts
1.133
149
Arts and Humanities; Clinical Psychology
Arts and Humanities; Psychology
2,023
35,988,099
Complete mitochondrial genome of freshwater pearl mussel Lamellidens marginalis (Lamarck, 1819) and its phylogenetic relation within unionidae family.
Molecular biology reports
Mol Biol Rep
49
10
10.1007/s11033-022-07857-5
eng
2,022
10
null
2,022
8
21
[BACKGROUND] Freshwater mussels play a key role in ecology and are often considered as ecological indicators. Conversely, these molluscs are one of the most threatened groups due to several anthropogenic factors. Knowledge of phylogenetic diversity would assist in formulating effective management and conservation measu...
Biogeography; Bivalvia; F-type mitochondrial genome; Monophyly; Parreysiinae
0.578
96
Medicine; Genetics; Molecular Biology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,988,095
Reproductive outcomes from ten years of elective oocyte cryopreservation.
Archives of gynecology and obstetrics
Arch Gynecol Obstet
306
5
10.1007/s00404-022-06711-0
eng
2,022
11
null
2,022
8
21
[RESEARCH QUESTION] To assess the relationship between the number of oocytes retrieved during elective oocyte cryopreservation (EOC) cycles with various clinical, biochemical, and radiological markers, including age, body mass index (BMI), baseline anti-Müllerian hormone (AMH), antral follicle count (AFC), Oestradiol l...
Elective oocyte cryopreservation; Fertility preservation; Livebirth rate; Vitrification
0.727
90
Medicine; Obstetrics and Gynecology
Medicine
2,022
35,988,055
Graphene Coated Ti-6Al-4V Exhibits Antibacterial and Antifungal Properties Against Oral Pathogens.
Journal of prosthodontics : official journal of the American College of Prosthodontists
J Prosthodont
32
6
10.1111/jopr.13595
eng
2,023
7
null
2,022
9
13
[PURPOSE] This study aimed to explore the antimicrobial properties of graphene coated Ti-6Al-4V to oral pathogens. [MATERIALS AND METHODS] Graphene directly synthesized on Ti-6Al-4V alloy was characterized by scanning electron microscopy (SEM) and Raman spectroscopy. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazoliu...
Candida albicans; Fusobacterium nucleatum; Graphene; Porphyromonas gingivalis; Ti-6Al-4V alloy
1.475
87
Dentistry
Dentistry
2,023
35,987,805
Associations of HDL subclasses and lipid content with complement proteins over the menopause transition: The SWAN HDL ancillary study: HDL and complement proteins in women.
Journal of clinical lipidology
J Clin Lipidol
16
5
10.1016/j.jacl.2022.07.015
eng
2,022
null
null
2,022
7
31
[BACKGROUND] The menopause transition (MT) could trigger low-grade chronic inflammation which may modify high-density lipoproteins (HDL) and lead to additional inflammatory responses contributing to atherosclerosis development. [OBJECTIVE] To test whether complement proteins C3 and C4 increase around the final menstrua...
Complement; Estradiol; High-density lipoproteins; Lipid; Menopause
1.256
79
Cardiology and Cardiovascular Medicine; Endocrinology, Diabetes and Metabolism; Internal Medicine; Nutrition and Dietetics
Medicine; Nursing
2,022
35,987,675
Spontaneous resolution of asymptomatic alumina matrix composite ceramic liner dissociation: a case report.
BMC musculoskeletal disorders
BMC Musculoskelet Disord
23
1
10.1186/s12891-022-05743-6
eng
2,022
8
20
2,022
8
20
[BACKGROUND] Total hip arthroplasty(THA)is widely used to treat end-stage hip disorders. Ceramic-on-ceramic total hip prostheses are widely used because of their durability. Alumina matrix composite (AMC), known as the fourth-generation ceramics, reduces implant fracture and wear rate compared to their predecessors. Ho...
Ceramics; Equipment failure; Hip prostheses; Total hip arthroplasty
0.716
131
Orthopedics and Sports Medicine; Rheumatology
Medicine
2,022
35,987,563
Measuring anxiety and fear of Covid-19 among older people: psychometric properties of anxiety and fear of Covid-19 scale (AMICO) in Spain.
BMC public health
BMC Public Health
22
1
10.1186/s12889-022-13960-w
eng
2,022
8
20
2,022
8
20
[BACKGROUND] The elderly population has proven to be a particularly vulnerable group with regard to the effects of the COVID-19 pandemic. The aim of this study was to study the psychometric properties of the Ansiedad y MIedo a Covid-19 scale (AMICO) on a population-based sample of elderly people. [METHODS] A descriptiv...
Anxiety; Assessment; COVID-19; Elderly people; Fear; Mental Health
1.307
211
Public Health, Environmental and Occupational Health
Medicine
2,022
35,987,557
Antihypertensive and Statin Medication Adherence Among Medicare Beneficiaries.
American journal of preventive medicine
Am J Prev Med
63
3
10.1016/j.amepre.2022.02.019
eng
2,022
9
null
2,022
7
21
[INTRODUCTION] Medication adherence is important for optimal management of chronic conditions, including hypertension and hypercholesterolemia. This study describes adherence to antihypertensive and statin medications, individually and collectively, and examines variation in adherence by demographic and geographic char...
null
2.181
260
Epidemiology; Public Health, Environmental and Occupational Health
Medicine
2,022
35,987,415
The pharmacological validation of the Xiao-Jian-Zhong formula against ulcerative colitis by network pharmacology integrated with metabolomics.
Journal of ethnopharmacology
J Ethnopharmacol
298
null
10.1016/j.jep.2022.115647
eng
2,022
11
15
2,022
8
17
[ETHNOPHARMACOLOGICAL RELEVANCE] Inflammatory bowel disease (IBD) is pathologically characterized by an immune response accommodative insufficiency and dysbiosis accompanied by persistent epithelial barrier dysfunction, and is divided into ulcerative colitis (UC) and Crohn's disease (CD). Its progression increases the ...
Dysbiosis; Inflammatory bowel disease; Mucosal healing; Xiao-Jian-Zhong formula
0.833
243
Drug Discovery; Pharmacology
Pharmacology, Toxicology and Pharmaceutics
2,022
35,987,333
Utilization of elderly donors in liver transplantation for patients with hepatocellular carcinoma: A national retrospective cohort study of China.
International journal of surgery (London, England)
Int J Surg
105
null
10.1016/j.ijsu.2022.106839
eng
2,022
9
null
2,022
8
18
[BACKGROUND] Profound organ shortages worldwide have led to the increased utilization of marginal organs from older individuals. However, the effectiveness of liver transplantation (LT) with organs from elderly donors for patients with hepatocellular carcinoma (HCC) remains controversial. The objective of the current s...
Deceased donor; Elderly donor; Hepatocellular carcinoma; Liver transplantation; Survival
2.597
99
Medicine; Surgery
Medicine
2,022
35,987,174
Renal and vascular outcomes in patients with isolated antiphospholipid syndrome nephropathy.
Journal of autoimmunity
J Autoimmun
132
null
10.1016/j.jaut.2022.102889
eng
2,022
10
null
2,022
8
18
[BACKGROUND] Antiphospholipid syndrome (APS) nephropathy (APSN) is a rare pattern with specific features resulting from microvascular lesions. The prognosis of APSN, outside of lupus nephritis, is unknown. The aim of this study was to describe the renal, vascular and overall outcomes of patients with APSN. [METHODS] Re...
Antiphospholipid syndrome; End-stage renal disease; Renal histology; Renal prognosis
2.594
147
Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,022
35,986,830
Predicting reachability to peripheral lesions in transbronchial biopsies using CT-derived geometrical attributes of the bronchial route.
International journal of computer assisted radiology and surgery
Int J Comput Assist Radiol Surg
18
2
10.1007/s11548-022-02723-y
eng
2,023
2
null
2,022
8
20
[PURPOSE] The bronchoscopist's ability to locate the lesion with the bronchoscope is critical for a transbronchial biopsy. However, much less study has been done on the transbronchial biopsy route. This study aims to determine whether the geometrical attributes of the bronchial route can predict the difficulty of reach...
Bronchoscopy; Geometrical index; Navigation; Reachability
0.853
71
Computer Graphics and Computer-Aided Design; Radiology, Nuclear Medicine and Imaging; Surgery; Biomedical Engineering; Computer Science Applications; Computer Vision and Pattern Recognition; Health Informatics; Medicine
Computer Science; Engineering; Medicine
2,023
35,986,740
GPR78 Regulates Autophagy and Drug Resistance in Non-small Cell Lung Cancer.
Alternative therapies in health and medicine
Altern Ther Health Med
29
1
null
eng
2,023
1
null
null
null
null
[CONTEXT] Lung cancer is one of the most common forms of cancer. Autophagy and apoptosis play an important role in the development of lung cancer. Researchers have found upregulation of GRP78 expression in cancer cells of various types. [OBJECTIVE] The study intended to explore the mechanism of G protein-coupled recept...
null
0.282
78
Complementary and Alternative Medicine; Medicine
Medicine
2,023
35,986,732
Molecular characteristics of incidental lower-grade glioma for treatment decision-making.
Journal of neurosurgery
J Neurosurg
138
3
10.3171/2022.6.JNS22967
eng
2,023
3
1
2,022
8
19
[OBJECTIVE] Several limitations are associated with the early diagnosis and treatment of incidental lower-grade glioma (iLGG), and due to its unknown molecular features, its management is categorized as either the "wait-and-see" strategy or immediate treatment. Therefore, in this study the authors explored iLGG's clini...
chemoresistance; incidental lower-grade glioma; mutation analysis; oncology; symptomatic lower-grade glioma; transcriptomic analysis
1.173
244
Neurology; Surgery
Medicine
2,023
35,986,326
Sleep disturbance, dyspnea, and anxiety following total joint arthroplasty: an observational study.
Journal of orthopaedic surgery and research
J Orthop Surg Res
17
1
10.1186/s13018-022-03288-x
eng
2,022
8
19
2,022
8
19
[BACKGROUND] Patient-Reported Outcomes Measurement Information System (PROMIS) domains for sleep disturbance, anxiety, and dyspnea have been under-reported for total joint arthroplasty (TJA). The aims of this study were to report postoperative differences for these domains based on TJA location and chronic pain state. ...
Anxiety; Chronic pain grade; Dyspnea; Patient-reported outcomes; Sleep disturbance; Total joint arthroplasty
0.744
75
Surgery; Orthopedics and Sports Medicine
Medicine
2,022
35,986,145
Association of social determinants with the severity of congenital heart disease.
Pediatric research
Pediatr Res
93
5
10.1038/s41390-022-02205-6
eng
2,023
4
null
2,022
8
19
[BACKGROUND] Congenital heart diseases are the most prevalent congenital malformations and cause greater morbi-mortality in newborns and infants. The aim of this study was to analyze the social determinants in families with children with the severity of congenital heart disease. [METHODS] Analytical cross-sectional stu...
null
1.184
176
Pediatrics, Perinatology and Child Health
Medicine
2,023
35,985,982
Stereotactic Ablative Radiation for Systemic Therapy-naïve Oligometastatic Kidney Cancer.
European urology oncology
Eur Urol Oncol
5
6
10.1016/j.euo.2022.06.008
eng
2,022
12
null
2,022
8
16
[BACKGROUND] Evidence-based guidelines for the management of systemic therapy-naïve oligometastatic renal cell carcinoma (RCC) are lacking. [OBJECTIVE] To evaluate the potential of stereotactic ablative radiotherapy (SAbR) to provide longitudinal disease control while preserving quality of life (QOL) in patients with s...
Oligometastasis; Renal cell carcinoma; Stereotactic ablative radiotherapy; Stereotactic body radiation therapy; Stereotactic radiation
2.597
56
Medicine; Oncology; Radiology, Nuclear Medicine and Imaging; Surgery; Urology
Medicine
2,022
35,985,848
Perioperative outcomes in minimally-invasive versus open surgery in infants undergoing repair of congenital anomalies.
Journal of pediatric surgery
J Pediatr Surg
57
12
10.1016/j.jpedsurg.2022.08.002
eng
2,022
12
null
2,022
8
10
[BACKGROUND] This study compared perioperative outcomes among infants undergoing repair of congenital anomalies using minimally invasive (MIS) versus open surgical approaches. [METHODS] The ACS NSQIP Pediatric (2013-2018) was queried for patients undergoing repair of any of the following 9 congenital anomalies: congeni...
Congenital anomaly; Laparoscopy; Minimally invasive surgery; Neonatology; Surgical outcomes; Thoracoscopy
0.873
147
Medicine; Pediatrics, Perinatology and Child Health; Surgery
Medicine
2,022
35,985,547
MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM.
Journal of hepatology
J Hepatol
77
6
10.1016/j.jhep.2022.07.017
eng
2,022
12
null
2,022
8
18
[BACKGROUND AND AIMS] How hepatic steatosis progresses to non-alcoholic steatohepatitis (NASH) is complicated and remains unclear. The mortality factor 4-like protein 1 (MORF4L1, also called MRG15) was previously identified as a master nuclear chromatin remodeler in the rhythmic regulation of lipid synthesis gene expre...
MRG15; NLRP3 inflammasome; TUFM; mitochondrial ClpXP protease; mitophagy; nonalcoholic fatty liver disease
7.398
319
Hepatology
Medicine
2,022
35,985,275
The safety and efficacy of probiotic supplementation for critically ill adult patients: a systematic review and meta-analysis.
Nutrition reviews
Nutr Rev
81
3
10.1093/nutrit/nuac059
eng
2,023
2
10
null
null
null
[CONTEXT] The safety and efficacy of probiotics during severe illness has been a subject of ongoing interest. The impact of probiotics can worsen nutritional status, which could potentially result in a deterioration of the patient's overall life-threatening status. [OBJECTIVE] This systematic review and meta-analysis e...
Bifido-bacterium; ICU; Lactobacillus; critical care; critically ill; intensive care; prebiotics; probiotics; synbiotics
1.565
185
Medicine; Nutrition and Dietetics
Medicine; Nursing
2,023
35,985,147
Experiences and needs of physiotherapists and exercise therapists regarding the management of working people with complaints of the arm, neck and shoulder (CANS): A focus group study.
Musculoskeletal science practice
Musculoskelet Sci Pract
62
null
10.1016/j.msksp.2022.102644
eng
2,022
12
null
2,022
8
13
[BACKGROUND] Non-traumatic complaints of the arm, neck and/or shoulder (CANS) are difficult-to-treat musculoskeletal conditions. CANS treatment has varying degrees of success, particularly in the working population. [OBJECTIVES] To evaluate the experiences and needs of physiotherapists (PTs) and exercise therapists (ET...
Complaints of the arm; Musculoskeletal conditions; Neck and/or shoulder (CANS); Physiotherapy; Self-management
null
null
null
null
null
35,985,081
Management of complicated acute sinusitis in the setting of concurrent COVID-19.
American journal of otolaryngology
Am J Otolaryngol
43
5
10.1016/j.amjoto.2022.103603
eng
2,022
null
null
2,022
8
13
[PURPOSE] Intraorbital and intracranial complications of acute bacterial rhinosinusitis require timely medical and surgical treatment to prevent the development of long-term neurologic sequelae. The era of Coronavirus Disease-2019 (COVID-19) has complicated the management of complicated acute rhinosinusitis, especially...
COVID-19; Complications; Intracranial abscess; Rhinosinusitis; SARS-CoV-2; Subperiosteal abscess
null
null
null
null
null
35,985,055
Acupuncture in treating obesity combined with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled clinical trials.
Complementary therapies in clinical practice
Complement Ther Clin Pract
49
null
10.1016/j.ctcp.2022.101658
eng
2,022
11
null
2,022
8
13
[BACKGROUND] and purpose: Most type 2 diabetes mellitus (T2DM) patients are accompanied by overweight or obesity, and it is difficult to concurrently solve these two issues with conventional treatment regimens without experiencing adverse effects. While clinical practice demonstrates that acupuncture is beneficial in t...
Acupuncture; Meta-analysis; Obesity; Type 2 diabetes mellitus
0.664
67
Complementary and Alternative Medicine
Medicine
2,022
35,984,687
Effects of Implementing an Acuity Tool on a Psychiatric Intensive Care Unit.
Journal of nursing care quality
J Nurs Care Qual
37
4
10.1097/NCQ.0000000000000652
eng
null
null
null
2,022
8
15
[BACKGROUND] Staff shortages, reduced budgets, and high acuity of violent psychiatric patients can create challenges in psychiatric intensive care units (PICUs). [LOCAL PROBLEM] Staffing of the psychiatric unit was based on patient census rather than evidence-based practices. [METHODS] A pre-/postintervention design wa...
null
null
null
null
null
null
35,984,655
Comparison of 6-Month Outcomes of Endovascular vs Surgical Revascularization for Patients With Critical Limb Ischemia.
JAMA network open
JAMA Netw Open
5
8
10.1001/jamanetworkopen.2022.27746
eng
2,022
8
1
2,022
8
1
[IMPORTANCE] The Bypass Versus Angioplasty for Severe Ischemia of the Leg randomized controlled trial showed comparable outcomes between endovascular revascularization (ER) and surgical revascularization (SR) for patients with critical limb ischemia (CLI). However, several observational studies showed mixed results. Mo...
null
4.108
154
Medicine
Medicine
2,022
35,984,521
Bowel stimulation before loop ileostomy closure to reduce postoperative ileus: a multicenter, single-blinded, randomized controlled trial.
Surgical endoscopy
Surg Endosc
37
5
10.1007/s00464-022-09510-5
eng
2,023
5
null
2,022
8
19
[INTRODUCTION] The objective of this study was to evaluate the impact of preoperative bowel stimulation on the development of postoperative ileus (POI) after loop ileostomy closure. [METHODS] This was a multicenter, randomized controlled trial (NCT025596350) including adult (≥ 18 years old) patients who underwent elect...
Bowel stimulation; Length of stay; Loop ileostomy closure; Postoperative ileus
1.12
178
Surgery
Medicine
2,023
35,984,511
Effect of heated humidified high-flow nasal cannula (HFNC) oxygen therapy in dyspnea patients with advanced cancer, a randomized controlled clinical trial.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Support Care Cancer
30
11
10.1007/s00520-022-07330-w
eng
2,022
11
null
2,022
8
19
[PURPOSE] Heated humidified high-flow nasal cannula (HFNC) oxygen therapy is one of the most important oxygen therapy methods, which are commonly applied to relieve dyspnea in advanced cancer patients. Our study aims to observe the efficacy and safety of HFNC oxygen therapy on dyspnea patients with advanced cancer and ...
Dyspnea; Neoplasms; Oxygen inhalation therapy; Patient comfort; Randomized controlled trial
0.984
143
Oncology
Medicine
2,022
35,984,415
Preliminary validation of the Norwegian version of misophonia questionnaire (MQ-NOR).
International journal of audiology
Int J Audiol
62
10
10.1080/14992027.2022.2111372
eng
2,023
10
null
2,022
8
19
[OBJECTIVE] To perform a psychometric validation of a Norwegian version of the Misophonia Questionnaire (MQ-NOR) and to test the link between the personality trait neuroticism and misophonia assessed with the MQ-NOR. [DESIGN] Participants completed online versions of the MQ-NOR on two occasions about two weeks apart an...
Misophonia questionnaire; Norwegian; misophonia; neuroticism; test-retest validation
0.942
102
Linguistics and Language; Speech and Hearing
Health Professions; Social Sciences
2,023
35,984,023
In silico Identification of Novel SARS-CoV-2 Main Protease and Nonstructural Protein 13 (nsp13) Inhibitors through Consensus Docking and Free Binding Energy Calculations.
Combinatorial chemistry high throughput screening
Comb Chem High Throughput Screen
26
6
10.2174/1386207325666220818141112
eng
2,023
null
null
null
null
null
[BACKGROUND] A new strain of a novel disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been recently declared a pandemic by the World Health Organization (WHO). The virus results in significant mortality and morbidity across the planet; therefore, novel treatments are urgently required....
Nsp13; SARS-CoV-2; consensus docking; main protease; molecular docking; virtual screening
null
null
null
null
null
35,983,705
Retrospective Clinical Evaluation of Subgingival Composite Resin Restorations with Deep-Margin Elevation.
The journal of adhesive dentistry
J Adhes Dent
24
null
10.3290/j.jad.b3240665
eng
2,022
8
19
2,022
8
19
[PURPOSE] To evaluate the long-term clinical quality of subgingivally placed composite resin restorations and the inflammatory status of surrounding supracrestal gingival and periodontal tissues. [MATERIALS AND METHODS] Patients with at least one subgingival restoration with deep-margin elevation placed between 2010 an...
gingival and periodontal inflammation; proximal box elevation; resin composite restoration.; subgingival defects
0.77
79
Oral Surgery; Orthodontics; Periodontics
Dentistry
2,022
35,983,622
Daprodustat for anaemia in patients with heart failure and chronic kidney disease: A randomized controlled study.
ESC heart failure
ESC Heart Fail
9
6
10.1002/ehf2.14109
eng
2,022
12
null
2,022
8
18
[AIMS] Hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors have been developed for the treatment of renal anaemia; however, no study has evaluated the safety and efficacy of HIF-PH inhibitors in patients with heart failure (HF). This study was designed to evaluate the safety and efficacy of daprodustat, a H...
Anaemia; Chronic kidney disease; Daprodustat; HIF-PH inhibitor; Heart failure; Study protocol
0.899
57
Cardiology and Cardiovascular Medicine
Medicine
2,022
35,983,454
Long-term treatment of dentine with triple antibiotic paste promotes stem cell viability and attachment.
Journal of Taibah University Medical Sciences
J Taibah Univ Med Sci
17
4
10.1016/j.jtumed.2022.01.007
eng
2,022
8
null
2,022
2
10
[OBJECTIVE] Successful regenerative endodontic procedures in dental treatment are critically associated with complete disinfection of the root canal and require irrigants and medicaments. One factor for consideration is the biocompatibility of the medicament as this can affect the intracanal dentine and subsequently th...
Cell viability; Dental pulp stem cells; Intracanal medicaments; Irrigated radicular dentine; Scanning electron microscope
0.418
37
Medicine
Medicine
2,022
35,983,448
The short synacthen test: Variations in methodology and protocols in KSA.
Journal of Taibah University Medical Sciences
J Taibah Univ Med Sci
17
4
10.1016/j.jtumed.2022.01.010
eng
2,022
8
null
2,022
2
11
[OBJECTIVES] This study aimed to compare the current Kingdom-wide practice with our prior institutional study on use of the short synacthen test (SST), and to determine whether physician specialty or grade is associated with a tendency toward using a particular protocol. [METHOD] We surveyed clinicians registered with ...
Addison disease; Adrenal insufficiency; Cosyntropin; Pituitary-adrenal system; Short synacthen test
0.418
37
Medicine
Medicine
2,022
35,983,366
Evaluation of stroke health education for primary school students in Dali, China.
Frontiers in public health
Front Public Health
10
null
10.3389/fpubh.2022.861792
eng
2,022
null
null
2,022
8
2
[OBJECTIVES] To provide us with some evidence to develop more targeted stroke intervention strategies, improve the health awareness of stroke among children, and advocate the health promotion campaign of "small hands holding big hands" among parents and children, we have conducted a health education program on stroke a...
children; effect; ethnic; evaluation; health education; stroke
1.125
119
Public Health, Environmental and Occupational Health
Medicine
2,022
35,983,354
Flexible Assertive Community Treatment in Rural and Remote Areas: A Qualitative Study of the Challenges and Adaptations of the Model.
Frontiers in public health
Front Public Health
10
null
10.3389/fpubh.2022.913159
eng
2,022
null
null
2,022
7
22
[BACKGROUND] Flexible assertive community treatment (FACT) is an innovative model for providing long-term treatment to people with severe mental illness. The model was developed in the Netherlands but is now used in other countries, including Norway, which has a geography different from the Netherlands, with many rural...
flexible assertive community treatment (FACT); innovation; mental health; modification; remote; rural
1.125
119
Public Health, Environmental and Occupational Health
Medicine
2,022
35,983,166
Emergency Department Visits Due to Dyspnea: Association with Inhalation Therapy in COPD and Cases with Adverse Drug Reactions.
International journal of chronic obstructive pulmonary disease
Int J Chron Obstruct Pulmon Dis
17
null
10.2147/COPD.S367062
eng
2,022
null
null
2,022
8
11
[PURPOSE] Dyspnea is a leading symptom of COPD that causes presentations in emergency departments or negatively impacts on them. Guideline-based inhalation therapies are intended to reduce dyspnea in COPD patients. This study analyzed how common guideline recommended inhalation therapy regimens are occurring in clinica...
adverse drug events; chronic obstructive pulmonary disease; dyspnea; emergency department; guideline therapy
null
null
null
null
null
35,983,118
Development and internal validation of preoperative and postoperative nomograms predicting quadrifecta outcomes following robotic radical prostatectomy.
Indian journal of urology : IJU : journal of the Urological Society of India
Indian J Urol
38
3
10.4103/iju.iju_381_21
eng
2,022
null
null
2,022
7
1
[INTRODUCTION] Literature on the factors predicting functional and oncological outcomes following robot-assisted radical prostatectomy (RARP) is sparse for the Indian population. Hence, the primary objective of this study was to develop preoperative and postoperative nomograms predicting these outcomes in patients with...
null
0.311
45
Urology
Medicine
2,022
35,983,001
Efficacy of Laparoscopic Radical Resection Combined with Neoadjuvant Chemotherapy and Its Impact on Long-Term Prognosis of Patients with Colorectal Cancer.
Evidence-based complementary and alternative medicine : eCAM
Evid Based Complement Alternat Med
2022
null
10.1155/2022/4774531
eng
2,022
null
null
2,022
8
9
[OBJECTIVE] The aim of the study is to examine the efficacy of laparoscopic radical resection of colorectal cancer combined with neoadjuvant chemotherapy and its impact on the overall prognosis of patients with colorectal cancer (CC). [METHODS] A total of 80 CC patients hospitalized and treated at our hospital between ...
null
null
null
null
null
null
35,982,961
Phase 1b clinical trial of pucotenlimab (HX008), a novel anti-PD-1 monoclonal antibody, combined with gemcitabine and cisplatin in the first-line treatment of metastatic triple-negative breast cancer.
Frontiers in oncology
Front Oncol
12
null
10.3389/fonc.2022.837963
eng
2,022
null
null
2,022
8
2
[BACKGROUND] Pucotenlimab, also called HX008, is a humanized anti-PD-1 antagonist IgG4 mAb. It blocks programmed cell death protein 1 (PD-1), programmed-death ligand 1 (PD-L1), and programmed death ligand-2 (PD-L2). In the CBCSG 006 trial, gemcitabine plus cisplatin (GP) has shown impressive antitumor activity as first...
cisplatin; gemcitabine; immunotherapy; metastatic triple-negative breast cancer; pucotenlimab
1.138
156
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,982,444
Longitudinal comparison of direct medical cost, radiological and health-related quality of life treatment outcomes between traditional growing rods and magnetically controlled growing rods from preoperative to maturity.
BMC musculoskeletal disorders
BMC Musculoskelet Disord
23
1
10.1186/s12891-022-05750-7
eng
2,022
8
18
2,022
8
18
[BACKGROUND] Magnetically controlled growing rods (MCGR) have replaced traditional growing rods (TGR) in the past decade, however, a comparison of their direct costs and treatment outcomes based on real longitudinal data is lacking. This study aims to compare the direct cost and treatment outcomes between TGR and MCGR,...
Direct cost; Early onset scoliosis; HRQoL; MCGR; TGR; Treatment outcomes
0.716
131
Orthopedics and Sports Medicine; Rheumatology
Medicine
2,022
35,982,374
Development of markers using microsatellite loci of two rove beetle species, Paederus fuscipes Curtis and Aleochara (Aleochara) curtula Goeze (Coleoptera: Staphylinidae), followed by analyses of genetic diversity and population structure.
Genes genomics
Genes Genomics
44
12
10.1007/s13258-022-01293-2
eng
2,022
12
null
2,022
8
18
[BACKGROUND] The family Staphylinidae is the most speciose beetle group in the world. The outbreaks of two staphylinid species, Paederus fuscipes and Aleochara (Aleochara) curtula, were recently reported in South Korea. None of research about molecular markers and genetic diversity have been conducted in these two spec...
Aleochara (Aleochara) curtula; Genetic diversity; Korea; Microsatellite; Paederus fuscipes; Population structure
null
null
null
null
null
35,982,283
Robotic repair of perineal hernias: a video vignette and review of the literature.
Surgical endoscopy
Surg Endosc
37
3
10.1007/s00464-022-09521-2
eng
2,023
3
null
2,022
8
18
[BACKGROUND] Perineal hernias can be secondarily acquired following abdominoperineal resection of the rectum. While transabdominal minimally invasive techniques have traditionally used laparoscopy, there are few studies published on the robotic platform, which has been gaining popularity for other types of hernia repai...
Da Vinci; MIS; Perineal hernia; Robotic
1.12
178
Surgery
Medicine
2,023
35,981,632
Pancreatic PCSK9 controls the organization of the β-cell secretory pathway via LDLR-cholesterol axis.
Metabolism: clinical and experimental
Metabolism
136
null
10.1016/j.metabol.2022.155291
eng
2,022
11
null
2,022
8
16
[BACKGROUND] Cholesterol is central to pancreatic β-cell physiology and alterations of its homeostasis contribute to β-cell dysfunction and diabetes. Proper intracellular cholesterol levels are maintained by different mechanisms including uptake via the low-density lipoprotein receptor (LDLR). In the liver, the proprot...
Cholesterol; Diabetes; Glucose homeostasis; Insulin; LDLR; PCSK9
2.886
174
Endocrinology; Endocrinology, Diabetes and Metabolism
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,981,303
Associations of Polypharmacy With Clinical Parameters, Function, and Health-Related Quality of Life in Psoriatic Arthritis.
Journal of clinical rheumatology : practical reports on rheumatic musculoskeletal diseases
J Clin Rheumatol
29
1
10.1097/RHU.0000000000001889
eng
2,023
1
1
2,022
8
18
[OBJECTIVE] The aim of this study was to assess predictors of polypharmacy and its effect on health-related quality of life in patients with psoriatic arthritis (PsA). [METHODS] This cross-sectional study was performed between February and December 2019. The number of medications was grouped into minor (2-4) and major ...
null
0.539
63
Medicine; Rheumatology
Medicine
2,023
35,980,951
Primary headaches increase the risk of dementias: An 8-year nationwide cohort study.
PloS one
PLoS One
17
8
10.1371/journal.pone.0273220
eng
2,022
null
null
2,022
8
18
[BACKGROUND] Headache, a highly prevalent neurological disorder, has consistently been linked with an elevated risk of dementia. However, most studies are focused on the relationship with migraine in limited age groups. Therefore, the objective of this research was to look at the link between various type of headaches ...
null
0.885
467
Multidisciplinary
Multidisciplinary
2,022
35,980,666
Outcomes Among Patients With Mucosal Head and Neck Squamous Cell Carcinoma Treated With Checkpoint Inhibitors.
JAMA otolaryngology-- head neck surgery
JAMA Otolaryngol Head Neck Surg
148
10
10.1001/jamaoto.2022.2284
eng
2,022
10
1
null
null
null
[IMPORTANCE] Immune checkpoint inhibitors (CPIs) are now part of standard therapy for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) because of improved outcomes compared with chemotherapy in clinical trials. However, data on outcomes in patients with HNSCC in the general population...
null
null
null
null
null
null
35,980,560
Expression and Prognostic Significance of Stem Cell Marker CD133 in Survival Rate of Patients with Colon Cancer.
Oncology and therapy
Oncol Ther
10
2
10.1007/s40487-022-00205-4
eng
2,022
12
null
2,022
8
18
[INTRODUCTION] Today, colon cancer is one of the most common types of gastrointestinal cancer worldwide. CD133 as a known cancer stem cell marker has been found effective in cell proliferation and differentiation in various cancers, including colon cancer. We aimed to investigate the relationship between CD133 expressi...
Carcinoma; Colon; Immunohistochemistry; Neoplastic stem cells; Rectum
null
null
null
null
null
35,980,492
Fingolimod does not prevent syndecan-4 shedding from the endothelial glycocalyx in a cultured human umbilical vein endothelial cell model of vascular injury.
Intensive care medicine experimental
Intensive Care Med Exp
10
1
10.1186/s40635-022-00462-7
eng
2,022
8
18
2,022
8
18
[BACKGROUND] Shedding of the endothelial glycocalyx (EG) is associated with poor outcomes in a range of conditions including sepsis. Fresh frozen plasma (FFP) restores the damaged EG to baseline thickness, however the mechanism for this effect is unknown, and some components of FFP have adverse effects unrelated to the...
Cell culture; Endothelium; FTY720; Fingolimod; Fresh frozen plasma; Glycocalyx; Human umbilical vein endothelial cells; Sphingosine 1-phosphate; Syndecan-1; Syndecan-4
0.973
40
Critical Care and Intensive Care Medicine; Emergency Medicine; Physiology
Medicine
2,022
35,980,483
Osteosarcoma pre-diagnosed as another tumor: a report from the Cooperative Osteosarcoma Study Group (COSS).
Journal of cancer research and clinical oncology
J Cancer Res Clin Oncol
149
5
10.1007/s00432-022-04156-1
eng
2,023
5
null
2,022
8
18
[PURPOSE] The course of osteosarcoma patients primarily treated as such has been well described. Little, however, is known about patients who were primarily treated assuming a different tumor diagnosis. [METHODS] The database of the Cooperative Osteosarcoma Study Group COSS was searched (4.435 primary high-grade centra...
Aneurysmatic bone cyst; Chemotherapy; Chondrosarcoma; Giant cell tumor; Osteosarcoma; Surgery
1.023
114
Medicine; Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,023
35,980,443
International urogynecology consultation chapter 3 committee 2; conservative treatment of patient with pelvic organ prolapse: Pelvic floor muscle training.
International urogynecology journal
Int Urogynecol J
33
10
10.1007/s00192-022-05324-0
eng
2,022
10
null
2,022
8
18
[INTRODUCTION AND HYPOTHESIS] This manuscript from Chapter 3 of the International Urogynecology Consultation (IUC) on Pelvic Organ Prolapse (POP) describes the current evidence and suggests future directions for research on the effect of pelvic floor muscle training (PFMT) in prevention and treatment of POP. [METHODS] ...
Long-term; Pelvic floor muscle training; Pelvic organ prolapse; Physical therapy; Postpartum; Surgery
0.765
109
Urology; Obstetrics and Gynecology
Medicine
2,022
35,980,415
The Use of Non-physician Prescribed Medications in Patients Presenting to Two Emergency Departments in a Low/Middle-income Country.
The western journal of emergency medicine
West J Emerg Med
23
4
10.5811/westjem.2022.2.54302
eng
2,022
6
17
2,022
6
17
[INTRODUCTION] With few trained healthcare practitioners and limited personal finances, many patients in low/middle income countries purchase prescription medications from non-physician prescribers (NPP). This study documents various aspects of this practice, including patterns of prescribing, and the patient's underst...
null
0.958
59
Emergency Medicine; Medicine
Medicine
2,022
35,980,168
Heterozygous BRCA1 and BRCA2 and Mismatch Repair Gene Pathogenic Variants in Children and Adolescents With Cancer.
Journal of the National Cancer Institute
J Natl Cancer Inst
114
11
10.1093/jnci/djac151
eng
2,022
11
14
null
null
null
[BACKGROUND] Genetic predisposition is has been identified as a cause of cancer, yet little is known about the role of adult cancer predisposition syndromes in childhood cancer. We examined the extent to which heterozygous pathogenic germline variants in BRCA1, BRCA2, PALB2, ATM, CHEK2, MSH2, MSH6, MLH1, and PMS2 contr...
null
5.409
394
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,979,960
Prophylactic Antibiotics in Patients with Traumatic Pneumocephalus or Cerebrospinal Fluid Leak.
The American surgeon
Am Surg
89
7
10.1177/00031348221117041
eng
2,023
7
null
2,022
8
18
[INTRODUCTION] Pneumocephalus and cerebrospinal fluid (CSF) leaks are uncommon after trauma, but they expose the sterile CSF to environmental pathogens and create theoretical risk of central nervous system infection (CNSI). Prophylactic antibiotics are commonly given to these patients, but there is a paucity of evidenc...
central nervous system infection; cerebrospinal fluid leak; facial trauma; head trauma; pneumocephalus
null
null
null
null
null
35,979,703
Effects of external electrical stimulation added to pelvic floor muscle training in women with stress urinary incontinence: A randomized controlled study.
Neurourology and urodynamics
Neurourol Urodyn
41
8
10.1002/nau.25022
eng
2,022
11
null
2,022
8
18
[OBJECTIVE] In this study, the combination of external electrical stimulation (EES) with pelvic floor muscle training (PFMT) was assessed to determine if it yielded better results than PFMT or EES alone for treatment of stress urinary incontinence (SUI). [STUDY DESIGN] Fifty-one women with SUI were randomly allocated t...
external electrical stimulation; pelvic floor; pelvic floor dysfunction; pelvic floor muscle training; stress urinary incontinence
0.721
112
Urology; Neurology
Medicine
2,022
35,979,300
Isolated cryptococcal osteomyelitis of the ulna in an immunocompetent patient: A case report.
World journal of clinical cases
World J Clin Cases
10
19
10.12998/wjcc.v10.i19.6617
eng
2,022
7
6
null
null
null
[BACKGROUND] Cryptococcal osteomyelitis is a bone infection caused by cryptococcus. As an opportunistic infection, bone cryptococcosis usually occurs in patients with immunodeficiency diseases or in those undergoing immunosuppressive therapy and often displays characteristics of disseminated disease. Isolated cryptococ...
Case report; Cryptococcus neoformans; Immunocompetence; Isolated lesions; Osteomyelitis; Ulna
null
38
Medicine
Medicine
2,022
35,979,255
The Effect and Mechanism of Curcumin Combined with Carboplatin Chemotherapy Promoting on Apoptosis of Lung Cancer HCC827 Cells.
Journal of immunology research
J Immunol Res
2022
null
10.1155/2022/1932692
eng
2,022
null
null
2,022
8
8
[OBJECTIVE] To investigate the effect and mechanism of curcumin (CUR) killing lung cancer HCC827 cell spheres. [METHOD] HCC827 cell spheres were cultured in serum-free medium, and the protein expression of CD133, SOX2, EpCAM, and ABCG2 was detected by western blot. MTT was used to evaluate the cell viability of HCC827 ...
null
0.899
122
Medicine; Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,022
35,979,222
Malnutrition, Eating Habits, Food Consumption, and Risk Factors of Malnutrition among Students at the University of Maroua, Cameroon.
Journal of nutrition and metabolism
J Nutr Metab
2022
null
10.1155/2022/1431743
eng
2,022
null
null
2,022
8
8
[METHODS] Three hundred and thirty students of both sexes, aged between 17 and 35 years old, were recruited from January to February 2018. Anthropometric parameters (weight, height, waist and hip circumference, and BMI) were measured, and an eating and lifestyle questionnaire was administered to each participant, as we...
null
0.62
61
Food Science; Nutrition and Dietetics; Endocrinology, Diabetes and Metabolism
Agricultural and Biological Sciences; Medicine; Nursing
2,022
35,979,189
Dedicated Psychiatry Clinic for Inflammatory Bowel Disease Patients Has a Positive Impact on Depression Scores.
Inflammatory intestinal diseases
Inflamm Intest Dis
7
2
10.1159/000520797
eng
2,022
7
null
2,021
11
10
[BACKGROUND] Psychiatric disorders, including anxiety and depression, are significantly more common in patients with inflammatory bowel disease (IBD). We established an integrated psychiatry clinic for IBD patients at our tertiary center IBD clinic to provide patients with critical, but frequently unavailable, coordina...
Crohn's disease; Inflammatory bowel disease; Mental health; Psychological intervention; Ulcerative colitis
null
null
null
null
null
35,979,177
A nationwide comparison of staggered and simultaneous bilateral knee arthroplasty during a single hospitalization: Trends, risks and benefits.
Journal of orthopaedic translation
J Orthop Translat
36
null
10.1016/j.jot.2022.05.001
eng
2,022
9
null
2,022
8
5
[BACKGROUND] We aimed to: (1) perform a nationwide trend analysis of staggered and simultaneous bilateral knee arthroplasty (KA); (2) investigate patient demographics and hospital characteristics in two groups; and (3) compare the outcomes of two groups with a focus on complications, length of stay (LOS) and hospitaliz...
Benefits; Bilateral knee arthroplasty; Risks; Trends
1.077
60
Orthopedics and Sports Medicine
Medicine
2,022
35,979,157
Novel multiplex stool-based assay for the detection of early-stage colon cancer in a Chinese population.
World journal of gastroenterology
World J Gastroenterol
28
24
10.3748/wjg.v28.i24.2705
eng
2,022
6
28
null
null
null
[BACKGROUND] Stool DNA (sDNA) methylation analysis is a promising, noninvasive approach for colorectal cancer screening; however, reliable biomarkers for detecting early-stage colon cancer (ECC) are lacking, particularly in the Chinese population. [AIM] To identify a novel stool-based assay that can improve the effecti...
Colon cancer; DNA methylation; Early screening; Fecal immunochemical test; Stool biomarker
null
null
null
null
null
35,978,943
A Home-Based Dyadic Music-with-Movement Intervention for People with Dementia and Caregivers: A Hybrid Type 2 Cluster-Randomized Effectiveness-Implementation Design.
Clinical interventions in aging
Clin Interv Aging
17
null
10.2147/CIA.S370661
eng
2,022
null
null
2,022
8
11
[BACKGROUND] Integrating evidence-based music-with-movement into routine practices for people with dementia requires effective implementation strategies. The objectives of this study were to evaluate the clinical efficacy of the intervention and to examine the effectiveness of the implementation strategies in promoting...
acceptability; dementia; implementation; music; well-being
0.923
114
Medicine; Geriatrics and Gerontology
Medicine
2,022
35,978,663
COVID-19 liver and gastroenterology findings: An in silico analysis of SARS-CoV-2 interactions with liver molecules.
World journal of hepatology
World J Hepatol
14
6
10.4254/wjh.v14.i6.1131
eng
2,022
6
27
null
null
null
[BACKGROUND] Coronavirus disease 19 (COVID-19) has not only been shown to affect the respiratory system, but has also demonstrated variable clinical presentations including gastrointestinal tract disorders. In addition, abnormalities in liver enzymes have been reported indicating hepatic injury. It is known that severe...
Bioinformatics; COVID-19; Cell signaling pathway; Liver injury; SARS-CoV-2
null
null
null
null
null
35,978,417
An analysis of COVID-19 information sources.
Journal of pharmaceutical policy and practice
J Pharm Policy Pract
15
1
10.1186/s40545-022-00446-8
eng
2,022
8
17
2,022
8
17
[BACKGROUND] The COVID-19 pandemic has brought new situations that require the effective delivery of health information across the world and it's important to offer clear, consistent, and credible information on the pandemic to mitigate and control the outbreak. [AIM] To assess COVID-19 information source, need and tru...
COVID-19; COVID-19 information gaps; COVID-19 information source; COVID-19 information trust
0.574
35
Pharmacology, Toxicology and Pharmaceutics; Pharmacy; Health Policy
Health Professions; Medicine; Pharmacology, Toxicology and Pharmaceutics
2,022
35,978,223
Push-out bond strength of fiber posts to irradiated and non-irradiated intraradicular dentin.
Clinical oral investigations
Clin Oral Investig
26
12
10.1007/s00784-022-04666-9
eng
2,022
12
null
2,022
8
18
[OBJECTIVES] The aim of this study is to evaluate the influence of ionizing radiotherapy on the resin-dentin interface in endodontically treated teeth restored with fiber posts using a dual-cure resin cement performed with the etch-and-rinse (ER) and self-etch (SE) approaches in terms of push-out bond strength (MPa), a...
Dentin; Push-out; Radiotherapy; Scanning electron microscopy
0.91
108
Dentistry
Dentistry
2,022
35,978,110
Clinical characteristics, causes and predictors of outcomes in patients with in-hospital cardiac arrest: results from the SURVIVE-ARREST study.
Clinical research in cardiology : official journal of the German Cardiac Society
Clin Res Cardiol
112
2
10.1007/s00392-022-02084-1
eng
2,023
2
null
2,022
8
17
[INTRODUCTION] In-hospital cardiac arrest (IHCA) is acutely life-threatening and remains associated with high mortality and morbidity. Identifying predictors of mortality after IHCA would help to guide acute therapy. [METHODS] We determined patient characteristics and independent predictors of 30-day in-hospital mortal...
Hospitalization; In-hospital cardiac arrest; Mortality; Outcomes; Survival
1.416
87
Cardiology and Cardiovascular Medicine; Medicine
Medicine
2,023
35,978,103
Relationships between intrauterine fetal growth trajectories and markers of adiposity and inflammation in young adults.
International journal of obesity (2005)
Int J Obes (Lond)
46
10
10.1038/s41366-022-01203-2
eng
2,022
10
null
2,022
8
17
[BACKGROUND] There is now good evidence that events during gestation significantly influence the developmental well-being of an individual in later life. This study aimed to investigate the relationships between intrauterine growth trajectories determined by serial ultrasound and subsequent markers of adiposity and inf...
null
1.438
258
Endocrinology, Diabetes and Metabolism; Medicine; Nutrition and Dietetics
Medicine; Nursing
2,022
35,976,513
Neratinib in advanced HER2-positive breast cancer: experience from the royal Marsden hospital.
Breast cancer research and treatment
Breast Cancer Res Treat
195
3
10.1007/s10549-022-06703-3
eng
2,022
10
null
2,022
8
17
[PURPOSE] To describe the tolerability and efficacy of neratinib as a monotherapy and in combination with capecitabine in advanced HER2-positive breast cancer in a real-world setting. [METHODS] Patients who received neratinib for advanced HER2-positive at the Royal Marsden Hospital NHS Trust between August 2016 and May...
Advanced breast cancer; Brain metastases; HER2-positive; Tyrosine kinase inhibitor
1.442
184
Oncology; Cancer Research
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,976,481
A reproducible and repeatable digital method for quantifying nasal and sinus airway changes following suture palatine expansion.
Sleep breathing = Schlaf Atmung
Sleep Breath
27
3
10.1007/s11325-022-02691-2
eng
2,023
6
null
2,022
8
17
[PURPOSE] The airway complex is modified by palatine expansion. Computer tomography has been used in the past to determine the change in volume, but there was a lack of a specific, reproducible method for this purpose. The present study sought to determine the accuracy, reproducibility, and repeatability of an innovati...
Maxillary sinus; Nasal airway; Orthodontics; Rapid maxillary expansion; Suture palatal expansion
null
null
null
null
null
35,976,386
Characterization and clinical management of abnormal cytology findings in pregnant women: a retrospective analysis.
Archives of gynecology and obstetrics
Arch Gynecol Obstet
306
6
10.1007/s00404-022-06699-7
eng
2,022
12
null
2,022
8
17
[PURPOSE] The diagnosis of cervical intraepithelial neoplasia during pregnancy poses a great challenge to the treating clinician and the patient. According to the current guidelines, watchful waiting during pregnancy can be justified. Only in cases of invasion, immediate treatment may be indicated. However, few data ar...
Cervical cancer; Dysplasia; Pregnancy
0.727
90
Medicine; Obstetrics and Gynecology
Medicine
2,022
35,976,327
Cannabidiol and epilepsy in Brazil: a current review.
Arquivos de neuro-psiquiatria
Arq Neuropsiquiatr
80
5 Suppl 1
10.1590/0004-282X-ANP-2022-S137
eng
2,022
5
null
null
null
null
[BACKGROUND] Cannabidiol (CBD) has become a promising therapeutic option in the treatment of epilepsy. Recent studies provide robust evidence that CBD is effective and safe. Limitations in current knowledge and regulatory issues still limit CBD use. CBD use regarding epilepsy types still lacks clear guidelines. [OBJECT...
null
0.391
60
Neurology; Neurology; Biological Psychiatry
Medicine; Neuroscience
2,022
35,976,067
Assessment of serum chemerin levels in acanthosis nigricans: A case-control study.
Journal of cosmetic dermatology
J Cosmet Dermatol
21
11
10.1111/jocd.15311
eng
2,022
11
null
2,022
9
20
[BACKGROUND] Acanthosis nigricans (AN) is an asymptomatic skin condition linked to several underlying systemic conditions. Chemerin is an adipokine that increases during inflammatory disorders such as metabolic syndrome (MetS). [AIMS] This case-control study investigates the link between AN and the underlying MetS and ...
acanthosis nigricans; chemerin; nigricans; serum; study
0.61
67
Dermatology
Medicine
2,022
35,975,662
Lower serum alpha 1 antitrypsin levels in patients with severe COVID-19 compared with patients hospitalized due to non-COVID-19 pneumonia.
Infectious diseases (London, England)
Infect Dis (Lond)
54
12
10.1080/23744235.2022.2111464
eng
2,022
12
null
2,022
8
17
[INTRODUCTION] Alpha 1 antitrypsin (A1AT) is the major human blood serine protease inhibitor. Transmembrane serine protease 2 (TMPRSS2), which is crucial for SARS-CoV-2 cell entry, is inhibited by A1AT. Therefore, we hypothesized that individuals with diminished levels of A1AT may be more prone to SARS-CoV-2 infection ...
A1AT; Alpha-1 antitrypsin; COVID-19; SARS-CoV-2; TMPRSS2; pneumonia
1.146
84
Immunology and Microbiology; Infectious Diseases; Medicine; Microbiology
Immunology and Microbiology; Medicine
2,022
35,975,585
Protecting children from COVID-19: examining U.S. parents motivation and behaviour using an integrated model of self-determination theory and the theory of planned behaviour.
Psychology health
Psychol Health
39
6
10.1080/08870446.2022.2111681
eng
2,024
6
null
2,022
8
17
[OBJECTIVES] This longitudinal study applied the integrated model of self-determination theory (SDT) and the theory of planned behaviour (TPB) to explain COVID-19 preventive behaviours among parents of young children in the United States. [DESIGN] The study adopted a two-wave longitudinal study design. Parents (N = 681...
COVID-19; behavioural adherence; health education; pandemic; parent and children; self-determination theory; theory of planned behaviour
null
null
null
null
null
35,975,486
The Correlation between Serum Lipoprotein(a) and Risk of Mortality in Patients on Peritoneal Dialysis.
Clinical laboratory
Clin Lab
68
8
10.7754/Clin.Lab.2022.220102
eng
2,022
8
1
null
null
null
[BACKGROUND] Patients with peritoneal dialysis commonly have severe disorders of lipid metabolism, with particularly severe changes in serum lipoprotein(α) [Lp(α)]. Serum Lp(α) may play a role in the risk of mortality in peritoneal dialysis patients. The aim was to investigate the correlation between high serum Lp(α) l...
null
null
null
null
null
null
35,975,387
Ureteropelvic junction obstructions: Is side a prognostic factor?
Nigerian journal of clinical practice
Niger J Clin Pract
25
8
10.4103/njcp.njcp_305_22
eng
2,022
8
null
null
null
null
[BACKGROUND] Ureteropelvic junction obstructions (UPJOs) occur more frequently on the left than on the right side. Among patients diagnosed during the neonatal period, those with left-side UPJO have a more severe course than those with right-side UPJO. [AIM] This study examined clinical advances in the surgical managem...
Hydronephrosis; pediatric; pyeloplasty; ureteropelvic junction obstruction
0.277
39
Medicine
Medicine
2,022
35,975,315
Confronting the unknown-Nursing surveillance of COVID-19-infected patients through remote telephone calls and in an on-site urgent clinic.
Journal of advanced nursing
J Adv Nurs
78
11
10.1111/jan.15355
eng
2,022
11
null
2,022
8
16
[AIM] To describe nursing surveillance of coronavirus disease 2019 (COVID-19)-infected patients through remote telephone calls and in an on-site urgent clinic during the first wave of the pandemic as experienced by nurses providing the care. [DESIGN] Qualitative descriptive study. [METHODS] Data were collected through ...
COVID-19; Coronavirus disease 2019; ambulatory care; nursing; outpatient clinics; pandemics; qualitative research; telemedicine; triage; urgent care
0.913
187
Nursing
Nursing
2,022
35,975,292
Between a rock and a hard place: Nurse managers' experiences of large-scale organizational change in the public health service.
Journal of advanced nursing
J Adv Nurs
78
10
10.1111/jan.15413
eng
2,022
10
null
2,022
8
16
[BACKGROUND] Nurse managers are often at the forefront of implementing organizational changes. Studies suggest that conflicting pressures and stress are high during such times, though little is known of how nurse managers experience the continuing run of change initiatives. [AIMS] To explore nurse managers' experience ...
conflicting pressure; nurse manager; nurse work life; organizational change; qualitative research
0.913
187
Nursing
Nursing
2,022