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40,390,697
The angiotensin receptor blocker, losartan, reduces inflammation and fibrosis, and prevents relapse of fibrosis after steroid-induced remission, in mice prone to Crohn's disease-like ileitis.
Journal of Crohn's & colitis
J Crohns Colitis
19
6
10.1093/ecco-jcc/jjaf083
eng
2,025
6
4
null
null
null
[BACKGROUND AND AIMS] The renin-angiotensin system (RAS) is known to modulate fibrosis, which is a common complication of ileal Crohn's disease. We tested the efficacy of losartan, an angiotensin receptor blocker, to treat intestinal fibrosis in relevant preclinical models of Crohn's-like disease. [METHODS] Effector mo...
angiotensin receptor blockers; intestinal fibrosis
null
null
null
null
null
40,390,215
An Integrated Computational Approach to Identify Potent HIV-1 Protease Inhibitors from Marine Sources.
Combinatorial chemistry & high throughput screening
Comb Chem High Throughput Screen
null
null
10.2174/0113862073344783241205075752
eng
2,025
5
16
2,025
5
16
[INTRODUCTION] This study aimed to identify marine-derived protease inhibitors with potential applications in immunogenicity-targeted therapies. [METHOD] Starting with a pharmacophore model based on the GRL-09510 complex (PDB ID: 5v4y), we isolated three critical features (RAA) that facilitated the selection of 192 can...
HIV-1 PR; density functional theory; molecular docking; molecular dynamics; pharmacophore
null
null
null
null
null
40,390,162
The intersection between firearm injury prevention and surgical practice: A qualitative study.
The journal of trauma and acute care surgery
J Trauma Acute Care Surg
99
1
10.1097/TA.0000000000004612
eng
2,025
7
1
2,025
5
20
[BACKGROUND] Previous work demonstrates that counseling trauma patients on firearm safety is difficult for US surgeons to effectively incorporate into clinical practice. The objective of this study was to understand firearm-owning surgeons' perspectives on their role in firearm injury prevention. [METHODS] We conducted...
Firearms; firearm violence; injury prevention; interview study; preventable injury
1.29
217
Critical Care and Intensive Care Medicine; Surgery
Medicine
2,024
40,390,002
Immune thrombotic thrombocytopenic purpura and diabetic ketoacidosis: a case report and literature review.
Thrombosis journal
Thromb J
23
1
10.1186/s12959-025-00740-w
eng
2,025
5
19
2,025
5
19
[BACKGROUND] Thrombotic thrombocytopenic purpura (TTP) is an uncommon and life-threatening disorder caused by a deficiency of ADAMTS-13, and eventually leads to microangiopathic hemolytic anemia, severe thrombocytopenia, and organ damages. Acute TTP events could be triggered by infections, or inflammations in the conte...
Acute kidney injury; Diabetic ketoacidosis; Thrombotic thrombocytopenia purpura
0.663
51
Hematology
Medicine
2,024
40,389,955
Impact of implant abutment materials on force damping response and marginal fit of implant supported restoration.
BMC oral health
BMC Oral Health
25
1
10.1186/s12903-025-06112-0
eng
2,025
5
20
2,025
5
20
[BACKGROUND] The marginal fit and force-damping response of implant-supported restorations play critical roles in the long-term success of dental implants. This study evaluates the effect of implant abutment materials- resin-ceramic material, lithium disilicate, PEEK, and Titanium- on implant-supported restorations' ma...
Cementation; Dental Restoration; Force Damping Response; Implant Abutment; Marginal Fit
0.843
80
Dentistry
Dentistry
2,024
40,389,865
Type 2 diabetes mellitus as a predictor of severe outcomes in COVID-19 - a systematic review and meta-analyses.
BMC infectious diseases
BMC Infect Dis
25
1
10.1186/s12879-025-11089-w
eng
2,025
5
19
2,025
5
19
[BACKGROUND] The COVID-19 pandemic has posed significant challenges to global health, with type 2 diabetes mellitus (T2DM) emerging as a key risk factor for adverse outcomes. This study systematically reviews and quantifies the association between T2DM and COVID-19 outcomes, including mortality, severity, and need for ...
COVID-19; Disease severity; Mechanical ventilation; Meta-analysis; Mortality; Type 2 Diabetes Mellitus
1.035
137
Infectious Diseases
Medicine
2,024
40,389,785
Development and validation of ultrasound-based radiomics deep learning model to identify bone erosion in rheumatoid arthritis.
Clinical rheumatology
Clin Rheumatol
44
7
10.1007/s10067-025-07481-1
eng
2,025
7
null
2,025
5
19
[OBJECTIVE] To develop and validate a deep learning radiomics fusion model (DLR) based on ultrasound (US) images to identify bone erosion in rheumatoid arthritis (RA) patients. [METHODS] A total of 432 patients with RA at two institutions were collected. Three hundred twelve patients from center 1 were randomly divided...
Bone erosion; Deep learning; Radiomics; Rheumatoid arthritis; Ultrasound
0.855
104
Medicine; Rheumatology
Medicine
2,024
40,389,670
Single-cell transcriptomic landscape reveals complex cellular heterogeneity and dysregulated signaling pathways in nasopharyngeal carcinoma.
Discover oncology
Discov Oncol
16
1
10.1007/s12672-025-02506-2
eng
2,025
5
19
2,025
5
19
[BACKGROUND] Nasopharyngeal carcinoma (NPC) is a common malignancy with a complex pathogenesis and diverse cellular composition. This study aimed to systematically analyze the transcriptional characteristics of different cell types in NPC and their roles in tumor development using single-cell transcriptomics. [METHODS]...
Cellular heterogeneity; Nasopharyngeal carcinoma; Signaling pathways; Single-cell transcriptomics; Tumor microenvironment
0.88
47
Endocrine and Autonomic Systems; Endocrinology; Endocrinology, Diabetes and Metabolism; Oncology; Cancer Research
Biochemistry, Genetics and Molecular Biology; Medicine; Neuroscience
2,024
40,389,389
Cancer-Specificity of Sex Differences and Sex-Specific Impact of Sociodemographic Characteristics in Cancer Patients' Health-Related Quality of Life: A Cross-Sectional Study.
Psycho-oncology
Psychooncology
34
5
10.1002/pon.70170
eng
2,025
5
null
null
null
null
[BACKGROUND] Health-related quality of life (HRQoL) is a multi-dimensional concept commonly assessed in patient-centered research on the impact of cancer and its treatment. Apart from disease and treatment characteristics, HRQoL is also influenced by sociodemographic variables. However, detailed evaluations of the impa...
cancer; interaction effects; oncology; sex
1.213
165
Experimental and Cognitive Psychology; Psychiatry and Mental Health; Oncology
Medicine; Psychology
2,024
40,389,198
Small Change, BIG Impact: Proposal of the Brain Injury Guidelines for Kids (kBIG).
Journal of pediatric surgery
J Pediatr Surg
60
8
10.1016/j.jpedsurg.2025.162372
eng
2,025
8
null
2,025
5
17
[BACKGROUND] The adult Brain Injury Guidelines (BIG) stratify patients with traumatic intracranial hemorrhage into one of three risk categories and supports management of lower risk traumatic brain injury (TBI) with minimal resources. While the BIG have been widely adopted by adult trauma centers, application to pediat...
Brain injury; Brain injury guidelines; Pediatric trauma
0.95
147
Medicine; Pediatrics, Perinatology and Child Health; Surgery
Medicine
2,024
40,388,731
Peripheral venous pressure measurements to evaluate congestion in pulmonary arterial hypertension.
Medicine
Medicine (Baltimore)
104
20
10.1097/MD.0000000000042422
eng
2,025
5
16
null
null
null
[BACKGROUND] Right atrial pressure (RAP) is an important prognostic criterion in pulmonary hypertension. Elevated mean RAP measured by cardiac catheterization is an independent risk factor for mortality. Accurate bedside assessment of congestion in the management of patients with PH remains challenging. As a continuous...
cardiac catheterization; peripheral venous pressure; right atrial pressure; systemic congestion
null
null
null
null
null
40,388,216
Assessment of Reference Values for Shoulder Ultrasonography and Effects of Position Change on Shoulder Hemodynamics.
Journal of clinical ultrasound : JCU
J Clin Ultrasound
53
4
10.1002/jcu.23927
eng
2,025
5
null
2,025
1
27
[PURPOSE] This study aimed to examine the reference values for shoulder ultrasonography and the effects of positional changes on anterior humeral circumflex artery (AHCA) hemodynamics. [METHODS] In this study, shoulder ultrasound was examined in 92 healthy participants (women: 48; men: 44; age 37.8 ± 13.6 years). The t...
anterior humeral circumflex artery; musculoskeletal ultrasonography; peak systolic velocity; rotator cuff tear
0.366
69
Radiology, Nuclear Medicine and Imaging
Medicine
2,024
40,387,915
Advancing the diagnosis and management of pudendal nerve entrapment: The role of neurophysiological studies and imaging-guided infiltrations.
Neuroradiology
Neuroradiology
null
null
10.1007/s00234-025-03645-7
eng
2,025
5
19
2,025
5
19
[PURPOSE] Pudendal nerve entrapment (PNE) diagnosis is not standardized. This leads to diagnosis delays, impacting quality of life and therapeutic outcomes. The main goal is to find the role of neurophysiological study (NFS) and Imaging-guided pudendal nerve infiltration (ImPNI) in PNE diagnosis and patient selection f...
CT-guided infiltrations; Neurophysiological studies; Pudendal nerve entrapment; Pudendal neuralgia; Surgery
0.843
109
Radiology, Nuclear Medicine and Imaging; Cardiology and Cardiovascular Medicine; Neurology
Medicine
2,024
40,387,434
Comparison of Carvedilol to Propranolol in Reduction of Hepatic Venous Pressure Gradient in Liver Cirrhosis: A Meta-Analysis.
Journal of gastroenterology and hepatology
J Gastroenterol Hepatol
40
6
10.1111/jgh.16999
eng
2,025
6
null
2,025
5
19
[BACKGROUND] Nonselective beta-blockers, such as propranolol and carvedilol, are used to prevent first decompensation in patients with clinically significant portal hypertension. [METHODS] We performed a systematic literature search of English language articles from inception in PubMed, Medline, and Cochrane databases ...
beta blockers; cirrhosis; hemodynamic; hepatic venous pressure gradient; portal hypertension
1.18
156
Gastroenterology; Hepatology
Medicine
2,024
40,387,194
The burden of ascites in cirrhosis.
Acta clinica Belgica
Acta Clin Belg
80
1-2
10.1080/17843286.2025.2506472
eng
2,025
null
null
2,025
5
19
[OBJECTIVES] Liver cirrhosis is a leading cause of morbidity and mortality worldwide, with complications such as ascites, spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome (HRS) significantly worsening prognosis. This paper aims to review the pathophysiology, diagnostic approaches, and management strate...
Ascites; cirrhosis; portal hypertension
0.417
44
Medicine
Medicine
2,024
40,387,163
Periosteal-guided bone regeneration on severely damaged sockets with simultaneous implant placement: The cortical shield cross-sectional study.
Clinical advances in periodontics
Clin Adv Periodontics
null
null
10.1002/cap.10364
eng
2,025
5
19
2,025
5
19
[BACKGROUND] Bone regeneration and simultaneous implant placement in severely damaged sockets are challenging and may require multiple grafting. Periosteal-guided bone regeneration enhances osteogenesis and wound healing shortening immediate and delay implant protocols. Clinical outcomes of a group of individuals that ...
bone grafting; bone regeneration; dental implant; osseointegration; tooth socket
0.316
9
Periodontics; Medicine
Dentistry; Medicine
2,024
40,387,087
The content of physical fitness training and the changes in physical fitness and functioning in orthopedic geriatric rehabilitation: an explorative observational study.
Disability and rehabilitation
Disabil Rehabil
null
null
10.1080/09638288.2025.2506823
eng
2,025
5
19
2,025
5
19
[PURPOSE] This explorative study investigates the content of physical fitness training and changes in physical fitness and functioning in the current practice of orthopedic geriatric rehabilitation (GR) in the Netherlands. [MATERIALS AND METHODS] The content of physical fitness training was analyzed in 48 patients from...
Geriatric rehabilitation; endurance training; physical fitness; physical functioning; resistance training
0.972
140
Rehabilitation
Medicine
2,024
40,386,836
Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT.
Health technology assessment (Winchester, England)
Health Technol Assess
29
17
10.3310/TNDG8641
eng
2,025
5
null
null
null
null
[BACKGROUND] Observational studies of people with chronic obstructive pulmonary disease using beta-blockers for cardiovascular disease indicate that beta-blocker use is associated with reduced risk of chronic obstructive pulmonary disease exacerbation. However, at the time this study was initiated, there had been no ra...
BETA-BLOCKER; BISOPROLOL; COPD; EXACERBATIONS; PLACEBO; RANDOMISED CONTROLLED TRIAL
null
null
null
null
null
40,386,815
LGBTQ+ Supportive and Inclusive Care Practices: Survey Data From the T1D Exchange Quality Improvement Collaborative.
Diabetes spectrum : a publication of the American Diabetes Association
Diabetes Spectr
38
2
10.2337/ds24-0025
eng
2,025
null
null
2,024
10
23
[OBJECTIVE] Living with type 1 diabetes is challenging, but more barriers exist when one also identifies as LGBTQ+ (lesbian, gay, bisexual, transgender, queer, or other gender-expansive identities). Acknowledging the importance of identifying this population and providing personalized care, the Health Resources and Ser...
null
0.899
47
Endocrinology, Diabetes and Metabolism; Internal Medicine
Medicine
2,024
40,386,812
Safety of a Novel Continuous Glucose Monitoring-Informed Insulin Bolus Calculator Mobile Application for People With Type 1 or Type 2 Diabetes.
Diabetes spectrum : a publication of the American Diabetes Association
Diabetes Spectr
38
2
10.2337/ds24-0032
eng
2,025
null
null
2,024
11
11
[BACKGROUND] Managing bolus insulin dosing can be a significant burden for people with diabetes, many of whom have limited numeracy skills. Insulin bolus calculators (IBCs) may improve glycemia as well as treatment satisfaction. [OBJECTIVE] The purpose of this study was to demonstrate the safety of a novel, continuous ...
null
0.899
47
Endocrinology, Diabetes and Metabolism; Internal Medicine
Medicine
2,024
40,386,753
Pembrolizumab-Associated Acute Esophageal Necrosis: A Case Report and Literature Review.
HCA healthcare journal of medicine
HCA Healthc J Med
6
2
10.36518/2689-0216.1846
eng
2,025
null
null
2,025
4
1
[BACKGROUND] Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. They pose challenges, particularly in the form of immune-related adverse events (irAEs). Although cases of gastrointestinal irAEs have been well-documented, acute esophageal necrosis (AEN) characterized by a circumferential blackenin...
acute esophageal necrosis; esophagitis; immune checkpoint inhibitors; necrosis; pembrolizumab
null
null
null
null
null
40,386,743
Metabolic diseases and lifestyle factors affect arthritis incidence in old Europeans - a cross analysis from the SHARE project.
Preventive medicine reports
Prev Med Rep
54
null
10.1016/j.pmedr.2025.103089
eng
2,025
6
null
2,025
4
28
[OBJECTIVE] In the context of global aging, the burden of metabolic diseases and arthritis is escalating, necessitating a more comprehensive understanding of the associations between these diseases. As modifiable factor the effect of lifestyle on the progression of arthritis also needs to be considered. Thus, this stud...
Arthritis; Life style
1.008
60
Public Health, Environmental and Occupational Health; Health Informatics
Medicine
2,024
40,386,644
Biomechanical Comparison of Transverse Capsulotomy Versus Longitudinal Capsulotomy of the Hip: A Cadaveric Study.
Orthopaedic journal of sports medicine
Orthop J Sports Med
13
5
10.1177/23259671251334145
eng
2,025
5
null
2,025
5
16
[BACKGROUND] Biomechanical effect on hip joint stability between the transverse interportal capsulotomy and the longitudinal capsulotomy in arthroscopy has not been fully investigated. [PURPOSE] To evaluate whether rotational stability and distraction resistance differ between the 2 capsulotomy directions using fresh-f...
capsular repair; longitudinal capsulotomy; stability; transverse interportal capsulotomy
1.258
68
Orthopedics and Sports Medicine
Medicine
2,024
40,386,455
Impact of biliary-pancreatic double stents on EUS-guided tissue acquisition among patients with solid pancreatic lesions: A multicenter study.
Endoscopic ultrasound
Endosc Ultrasound
13
5
10.1097/eus.0000000000000082
eng
2,024
null
null
2,024
11
6
[BACKGROUND AND OBJECTIVE] Although the impact of biliary stents on the accuracy of EUS-guided tissue acquisition (EUS-TA) is still controversial, the influence of biliary-pancreatic double stents on EUS-TA is even more inconclusive. The aim of the study was to determine whether the diagnostic yield of EUS-FNA in the d...
Biliary-pancreatic double stents; EUS-FNA; Endoscopic retrograde cholangiopancreatography; Obstructive jaundice
null
null
null
null
null
40,386,104
Investigating bovine coronavirus in Indian calves: Incidence, molecular evidence, and pathological role in bovine respiratory disease complex (BRDC).
Iranian journal of veterinary research
Iran J Vet Res
25
4
10.22099/ijvr.2024.48820.7142
eng
2,025
null
null
null
null
null
[BACKGROUND] Bovine coronavirus (BCoV) and bacterial pathogens contribute to bovine respiratory disease complex (BRDC) in young calves. However, the role of BCoV in BRDC occurrence and site-specific respiratory pathology in India remains poorly explored. [AIMS] This study aimed to assess BCoV prevalence in BRDC cases. ...
BCoV; Bovine respiratory disease complex; IHC; Pneumonia; RT-PCR
null
null
null
null
null
40,385,992
Clinical characteristics and risk factors of chronic critical illness in children with sepsis.
Frontiers in pediatrics
Front Pediatr
13
null
10.3389/fped.2025.1561044
eng
2,025
null
null
2,025
5
2
[OBJECTIVES] This study aimed to examine the clinical characteristics and risk factors associated with the development of chronic critical illness (CCI) in children with sepsis. [METHODS] A retrospective analysis was conducted on children diagnosed with sepsis and admitted to the Pediatric Intensive Care Unit (PICU) at...
chronic critical illness (CCI); clinical characteristics; immunosuppression; pediatric sepsis; risk factors
0.738
83
Pediatrics, Perinatology and Child Health
Medicine
2,024
40,385,941
Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury.
Journal of clinical and translational hepatology
J Clin Transl Hepatol
13
5
10.14218/JCTH.2024.00440
eng
2,025
5
28
2,025
3
3
[BACKGROUND AND AIMS] Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. However, research on COX-2 regulation of ferroptosis in chronic liver injury remains limited. This study aimed to investigate whether and how COX-2 regula...
Chronic liver injury; Cyclooxygenase-2; Ferroptosis; Hepatocytes; Lipid peroxidation; Nuclear factor erythroid 2-related factor 2; Oxidative stress
1.095
54
Gastroenterology; Hepatology
Medicine
2,024
40,385,871
Diagnosis of Digital Ischemia During the COVID-19 Pandemic: A Study From a Developing Country.
Cureus
Cureus
17
4
10.7759/cureus.82459
eng
2,025
4
null
2,025
4
17
[OBJECTIVE] Digital ischemia (DI) is an uncommon condition. Information on the etiology of DI is limited. This study aimed to determine the diagnosis of DI in a tertiary care center in Bangladesh. [METHODS] This cross-sectional study was conducted in the rheumatology department of Bangabandhu Sheikh Mujib Medical Unive...
covid-19; diagnosis; digital ischemia; vasculitis; vasculopathy
null
null
null
null
null
40,385,868
A Survey of Current Tobacco and Nicotine Product Users to Identify Barriers to Quitting Smoking in Germany.
Cureus
Cureus
17
4
10.7759/cureus.82419
eng
2,025
4
null
2,025
4
17
[BACKGROUND] Smoking rates remain high in Germany despite the well-known serious health risks. This survey assessed motivation to stop smoking in Germany and barriers to quitting smoking or switching to two types of smoke-free products (SFPs): e-cigarettes (E-cigs) and heated tobacco products (HTPs). [METHODS] In 2022,...
barriers to quitting smoking; e-cigarettes; heated tobacco products; smoke-free products; smoking; tobacco; tobacco harm reduction
null
null
null
null
null
40,385,697
Quantification of glucagon and oxyntomodulin by protein precipitation-immunoaffinity enrichment-LC-MS/MS.
Journal of mass spectrometry and advances in the clinical lab
J Mass Spectrom Adv Clin Lab
36
null
10.1016/j.jmsacl.2025.04.002
eng
2,025
4
null
2,025
4
11
[INTRODUCTION] Glucagon and oxyntomodulin are peptide hormones differentially released from proglucagon that function in regulating blood glucose. Their overlapping amino acid sequences make the development of specific immunoassays difficult, but the specificity of liquid chromatography-tandem mass spectrometry can be ...
Antibody enrichment; Diabetes; Glucagon; Liquid chromatography-tandem mass spectrometry; Oxyntomodulin
0.712
20
Medical Laboratory Technology; Spectroscopy; Clinical Biochemistry; Microbiology
Biochemistry, Genetics and Molecular Biology; Chemistry; Health Professions; Immunology and Microbiology
2,024
40,385,273
Diagnosis, management, and outcome of heart failure in congenitally corrected transposition of the great arteries (ccTGA)-a narrative review.
Cardiovascular diagnosis and therapy
Cardiovasc Diagn Ther
15
2
10.21037/cdt-24-334
eng
2,025
4
30
2,025
4
17
[BACKGROUND AND OBJECTIVE] Congenitally corrected transposition of the great arteries (ccTGA) remains a rare congenital disorder with a wide range of manifestations. The management of heart failure (HF) of the systemic right ventricle (RV), arrhythmias, heart block, and acquired cardiac conditions require a complex and...
Adults with congenital heart disease (ACHD); heart failure (HF); heart transplantation; ventricular assist device (VAD)
0.707
47
Cardiology and Cardiovascular Medicine
Medicine
2,024
40,385,026
Expression of transient receptor potential vanilloid type 1 (TRPV1) in colonic mucosa of patients with irritable bowel syndrome.
American journal of translational research
Am J Transl Res
17
4
10.62347/CUXA2243
eng
2,025
null
null
2,025
4
15
[OBJECTIVE] To investigate the expression pattern of the transient potential vanilloid type 1 (TRPV1) in the colonic mucosa of patients with irritable bowel syndrome (IBS), its clinical manifestations, and possible pathways of action. [METHODS] This study included 80 IBS patients (IBS group) diagnosed at The Second Aff...
Irritable bowel syndrome; colonic mucosa; transient receptor potential vanilloid type
null
null
null
null
null
40,384,823
A Study on Evaluation of Patient Satisfaction with National Tuberculosis Elimination Programme Services in Ahmedabad, India.
Indian journal of community medicine : official publication of Indian Association of Preventive Social Medicine
Indian J Community Med
50
2
10.4103/ijcm.ijcm_416_23
eng
2,025
null
null
2,025
1
30
[BACKGROUND] India accounts for the highest burden of tuberculosis cases in the world. Patient satisfaction is a key criterion for evaluating the quality of healthcare services as satisfaction has been found to be associated with superior compliance and better outcomes. Study was planned with the objectives to assess t...
Compliance; health system; national tuberculosis elimination programme; patient perspective; patient satisfaction questionnaire-18; satisfaction; tuberculosis; user experience
0.349
48
Public Health, Environmental and Occupational Health
Medicine
2,024
40,384,717
Prediction of fusion cage subsidence after transforaminal lumbar interbody fusion based on MRI endplate bone quality.
Quantitative imaging in medicine and surgery
Quant Imaging Med Surg
15
5
10.21037/qims-20204-2533
eng
2,025
5
1
2,025
4
24
[BACKGROUND] Transforaminal lumbar interbody fusion (TLIF) is a significant surgical method for treating degenerative lumbar diseases. Cage subsidence is one of the common postoperative complications of TLIF surgery. Current research lacks imaging prediction methods for cage subsidence in TLIF surgery. Endplate bone qu...
Transforaminal lumbar interbody fusion (TLIF); endplate bone quality (EBQ); vertebral bone quality (VBQ)
0.633
50
Radiology, Nuclear Medicine and Imaging
Medicine
2,024
40,384,679
The role of artificial intelligence in the diagnosis of diabetic retinopathy through retinal lesion features: a narrative review.
Quantitative imaging in medicine and surgery
Quant Imaging Med Surg
15
5
10.21037/qims-24-1791
eng
2,025
5
1
2,025
4
16
[BACKGROUND AND OBJECTIVE] In the field of ophthalmology, diabetic retinopathy (DR) is a diabetes-related eye condition that damages the retina. DR is a serious issue for working-age people and it is important to solve it at an early stage to avoid complete vision loss. The review covers together technical and clinical...
Artificial intelligence (AI); diabetic retinopathy (DR); explainable AI (XAI); meta learning; multimodality
0.633
50
Radiology, Nuclear Medicine and Imaging
Medicine
2,024
40,384,555
Comparative Efficacy of Digital 3D-Printed and Conventional Stable Occlusal Splints in the Treatment of Temporomandibular Disorders.
Journal of oral rehabilitation
J Oral Rehabil
null
null
10.1111/joor.14032
eng
2,025
5
19
2,025
5
19
[BACKGROUND] Temporomandibular disorders (TMD) are a group of diseases that affect the temporomandibular joint (TMJ), masticatory muscles and associated structures. [OBJECTIVE] This present study aims to explore the clinical comparative efficacy of digital 3D-printed and conventional handmade stable occlusal splints in...
3D printing; occlusal splint; temporomandibular disorders; temporomandibular joint
1.116
114
Dentistry
Dentistry
2,024
40,384,071
Large Language Models for Pre-mediation Counseling in Medical Disputes: A Comparative Evaluation against Human Experts.
Healthcare informatics research
Healthc Inform Res
31
2
10.4258/hir.2025.31.2.200
eng
2,025
4
null
2,025
4
30
[OBJECTIVES] Assessing medical disputes requires both medical and legal expertise, presenting challenges for patients seeking clarity regarding potential malpractice claims. This study aimed to develop and evaluate a chatbot based on a chain-of-thought pipeline using a large language model (LLM) for providing medical d...
Counseling; Dissent and Disputes; Large Language Models; Malpractice; Natural Language Processing
0.726
47
Biomedical Engineering; Health Informatics; Health Information Management
Engineering; Health Professions; Medicine
2,024
40,383,771
Pioneering evaluation in Brazil of microscope-integrated optical coherence tomography with a three-dimensional digital visualization system during pars plana vitrectomy for the treatment of macular hole.
International journal of retina and vitreous
Int J Retina Vitreous
11
1
10.1186/s40942-025-00671-8
eng
2,025
5
19
2,025
5
19
[BACKGROUND] This study aimed to characterize the clinical results and usability of intraoperative optical coherence tomography (iOCT) associated with a digital visualization system in vitreoretinal surgery for macular hole correction. [METHODS] This is a descriptive observational study of patients undergoing vitreoret...
ILM peeling; Macular hole; Vitrectomy; iOCT
0.967
36
Ophthalmology
Medicine
2,024
40,383,729
MoCA and MMSE for the detection of post-stroke cognitive impairment: a comparative diagnostic test accuracy systematic review and meta‑analysis.
Journal of neurology
J Neurol
272
6
10.1007/s00415-025-13146-5
eng
2,025
5
18
2,025
5
18
[BACKGROUND AND PURPOSE] Post-stroke cognitive impairment (PSCI) is one of the serious complications of stroke, which profoundly influences the quality of life of stroke survivors. The Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE) are the two cognitive screening tools most widely use...
Diagnostic accuracy; Mini-mental state examination; Montreal cognitive assessment; Post-stroke cognitive impairment
1.687
168
Neurology; Neurology
Medicine; Neuroscience
2,024
40,383,714
Comparison of Nicotine and Selected Flavorings Content Between Tobacco-Free and Tobacco-Containing Oral Pouches.
Nicotine tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Nicotine Tob Res
null
null
10.1093/ntr/ntaf105
eng
2,025
5
19
2,025
5
19
[INTRODUCTION] Flavored oral tobacco-free pouches (ONPs) are novel products that resemble traditional oral tobacco-containing pouches (OTPs) in design and route of administration. However, ONPs contain nicotine, various additives, and a filler material rather than tobacco leaves. Our study compares nicotine content, re...
Flavorings; Nicotine; ONP; Oral Nicotine Pouches
null
null
null
null
null
40,383,523
Hospital-based surveillance of respiratory syncytial virus in Central Queensland.
Communicable diseases intelligence (2018)
Commun Dis Intell (2018)
49
null
10.33321/cdi.2025.49.041
eng
2,025
5
19
2,025
5
19
[BACKGROUND] Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections, especially in infants and young children globally. Despite its impact, RSV testing and epidemiological data remain limited, particularly in regional Australia. Central Queensland, with its subtropical climate,...
Australia; RSV; RSV hospitalisation; RSV testing; acute lower respiratory tract infections; epidemiology; paediatric respiratory infections; respiratory illness; respiratory syncytial virus
0.357
13
Epidemiology; Infectious Diseases; Microbiology; Immunology
Immunology and Microbiology; Medicine
2,024
40,383,151
Evaluation of intracranial atherosclerotic stenosis burden, the use of dual antiplatelet therapy, and stroke recurrence in patients with minor stroke.
Journal of thrombosis and haemostasis : JTH
J Thromb Haemost
null
null
10.1016/j.jtha.2025.04.034
eng
2,025
5
16
2,025
5
16
[BACKGROUND] Intracranial atherosclerotic stenosis (ICAS) is a primary cause of ischemic stroke, but it might not be the main predictor of stroke recurrence. [OBJECTIVES] A comprehensive assessment of dual antiplatelet therapy (DAPT) effectiveness via ICAS burden (ICASB) is crucial for patients with minor stroke. [METH...
dual antiplatelet therapy; intracranial atherosclerotic stenosis burden; minor stroke; stroke recurrence
1.872
217
Hematology; Medicine
Medicine
2,024
40,383,042
Shared-decision making in pancreatic cancer: A scoping review.
Patient education and counseling
Patient Educ Couns
137
null
10.1016/j.pec.2025.108828
eng
2,025
8
null
2,025
5
13
[PURPOSE] This review aimed to map the current landscape of literature on informed and shared decision-making (SDM) among patients with pancreatic cancer (PC). [METHODS] PubMed, Scopus, Embase, and PsycINFO were queried for studies published before January 2024 that measured SDM or evaluated interventions targeted at S...
Pancreatic cancer; Patient-centered; Shared decision-making
1.237
168
Medicine
Medicine
2,024
40,382,980
Efficient labor- and cost-effective method: Validation of a paper-pencil group cognitive assessment for older adults.
Asian journal of psychiatry
Asian J Psychiatr
108
null
10.1016/j.ajp.2025.104535
eng
2,025
6
null
2,025
5
14
[AIM] With increasing rates of cognitive impairment in aging populations, efficient labor- and cost-effective screening methods are essential. The Paper-Pencil Group Cognitive Assessment (PAPLICA) is an innovative tool designed to assess cognitive function in groups, unlike traditional one-on-one cognitive assessments,...
Cognitive impairment; Older adults; Paper-Pencil Group Cognitive Assessment; Screening
1.126
70
Medicine; Psychology; Psychiatry and Mental Health
Medicine; Psychology
2,024
40,382,913
In Vitro Comparison of the Performance of Hydrophilic and Conventional Hydrophobic Resin-Based Fissure Sealants.
International dental journal
Int Dent J
75
4
10.1016/j.identj.2025.04.005
eng
2,025
8
null
2,025
5
17
[BACKGROUND] Hydrophilic sealants were developed to overcome hydrophobic sealant moisture sensitivity; however, there is still a limited understanding of their performance. This study aimed to compare microshear bond strength, penetration depth, and microleakage of hydrophilic UltraSeal XT hydro and hydrophobic Clinpro...
Bond strength; Hydrophilic; Hydrophobic; Microleakage; Microshear; Penetration; Sealant
0.972
81
Dentistry
Dentistry
2,024
40,382,442
Responses to checkpoint inhibition in metastatic triple negative breast cancer driven by divergent myeloid phenotypes.
Communications medicine
Commun Med (Lond)
5
1
10.1038/s43856-025-00860-4
eng
2,025
5
17
2,025
5
17
[BACKGROUND] Given the scarcity of effective therapeutic targets, metastatic triple negative breast cancer (mTNBC) has shorter survival times compared to other advanced breast cancer subtypes. Although chemo-immunotherapy with immune checkpoint inhibitors (ICIs) in PD-L1[+] mTNBC has shown promise, survival benefit rem...
null
2.098
28
Assessment and Diagnosis; Epidemiology; Internal Medicine; Medicine; Public Health, Environmental and Occupational Health
Medicine; Nursing
2,024
40,381,848
Comparing radio-hormone therapy to radical prostatectomy for patients with high-risk localized prostate cancer in an Afro-Caribbean population.
The French journal of urology
Fr J Urol
35
6-7
10.1016/j.fjurol.2025.102908
eng
2,025
8
null
2,025
5
15
[INTRODUCTION] Recommended treatments for patients with localized high-risk prostate cancer include radiotherapy with long-term hormone therapy and radical prostatectomy with lymph node dissection. Data regarding these treatments, for patients of African ancestry, are limited. This study aims to compare oncologic outco...
Afro-Caribbean; Cancer; Prostate; Radiotherapy; Surgery
0.315
37
Urology
Medicine
2,024
40,381,731
Synergizing Needs Assessments and Patient Preference Studies for Enhanced Patient-Centered Decision Making in Healthcare.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
Value Health
28
8
10.1016/j.jval.2025.04.2169
eng
2,025
8
null
2,025
5
15
[OBJECTIVES] Over the past decades, criticism has grown regarding the supply-driven approach of medicinal product development. In response, patient-centered methods have been developed to inform decision making. This perspective article aims to reflect on two of these methods, which are needs assessments and patient pr...
needs assessments; patient preference studies; patient preferences; patient-centered decision making; unmet medical needs
1.856
138
Health Policy; Medicine; Public Health, Environmental and Occupational Health
Medicine
2,024
40,435,099
Anti-PGL-I seropositivity and development of leprosy in contacts: a comprehensive analysis of sociodemographic determinants, genetic susceptibility, and exposure characteristics to Mycobacterium leprae.
Memorias do Instituto Oswaldo Cruz
Mem Inst Oswaldo Cruz
120
null
10.1590/0074-02760240061
eng
2,025
null
null
2,025
5
26
[BACKGROUND] Leprosy is an infectious disease that remains hyperendemic in several Brazilian regions. Patient contacts face a higher risk for infection and illness, which can subsequently contribute to the persistence of the disease. [OBJECTIVE] This study investigates the risk factors associated with anti-phenolic gly...
null
0.752
108
Medicine; Microbiology
Medicine
2,024
40,434,726
Prediction of hematogenous metastasis risk from molecular classification in gastric cancer.
International journal of surgery (London, England)
Int J Surg
111
8
10.1097/JS9.0000000000002587
eng
2,025
8
1
2,025
5
28
[BACKGROUND] Hematogenous metastasis (HM) poses a significant challenge in the treatment and outcome of gastric cancer (GC). This study identified and characterized molecular subtypes of GC associated with HM to develop predictive models and enhance precision medicine. [METHODS] We analyzed bulk-RNA sequencing data fro...
gastric cancer; hematogenous metastasis; molecular subtype; stemness
2.076
99
Medicine; Surgery
Medicine
2,024
40,434,688
Trabecular bone score predicts distal femur screw pull-out strength better than DXA bone mineral density, CT Hounsfield units, and cortical density.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Osteoporos Int
36
7
10.1007/s00198-025-07530-0
eng
2,025
7
null
2,025
5
28
[UNLABELLED] The purpose of the study was to evaluate trabecular bone score (TBS) technology for orthopedic application (TBSortho) as a predictor of a screw pull-out strength in a cadaveric model. This study finds that TBSortho correlates more strongly with the screw pull-out strength compared to cortical density, comp...
Computed tomography; Dual-energy X-ray absorptiometry; Trabecular bone score
1.466
201
Endocrinology, Diabetes and Metabolism; Medicine
Medicine
2,024
40,434,494
PET imaging of TREM2 in amyloid-beta induced neuroinflammation.
European journal of nuclear medicine and molecular imaging
Eur J Nucl Med Mol Imaging
null
null
10.1007/s00259-025-07358-0
eng
2,025
5
28
2,025
5
28
[PURPOSE] The triggering receptor expressed on myeloid cells 2 (TREM2) has become a promising target for biologics in both monitoring and treating neuroinflammation in Alzheimer's disease (AD). This study aimed to develop and compare bispecific anti-TREM2 antibodies featuring different transferrin receptor (TfR) binder...
Antibody-based PET; Bispecific antibody; Neuroinflammation; The blood-brain barrier
2.392
192
Medicine; Radiology, Nuclear Medicine and Imaging
Medicine
2,024
40,434,159
The effect of prophylactic cruroplasty on the incidence of hiatal herniation after robot-assisted minimally invasive esophagectomy (RAMIE).
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
Dis Esophagus
38
3
10.1093/dote/doaf041
eng
2,025
5
3
null
null
null
[BACKGROUND] Hiatal herniation (HH) following esophagectomy can cause severe complications and affect functional outcomes. This study assessed whether prophylactic cruroplasty during robot-assisted minimally invasive esophagectomy (RAMIE) reduces HH incidence. [METHODS] Patients undergoing curative RAMIE with cervical ...
cruroplasty; esophagectomy; hiatal hernia; ramie
null
null
null
null
null
40,433,858
Implications of omitting sentinel lymph node biopsy on adjuvant decision making for patients with small breast cancers.
Cancer
Cancer
131
11
10.1002/cncr.35910
eng
2,025
6
1
null
null
null
[BACKGROUND] Selective omission of sentinel lymph node biopsy (SLNB) in patients with early breast cancer limits surgical morbidity. Adoption of this strategy relies on multidisciplinary consensus. Understanding how SLNB omission influences guideline-based adjuvant treatment decisions, and the proportion of patients im...
adjuvant therapy; breast cancer; multidisciplinary decision making; omission of SLNB; sentinel lymph node biopsy (SLNB)
2.947
349
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,433,766
Feasibility of Endoscopic Ultrasound-Guided Tissue Acquisition for < 20-mm Upper Gastrointestinal Subepithelial Lesions.
Journal of gastroenterology and hepatology
J Gastroenterol Hepatol
40
8
10.1111/jgh.17029
eng
2,025
8
null
2,025
5
28
[BACKGROUND] There are few reports on the usefulness of endoscopic ultrasound-guided tissue acquisition (EUS-TA) for upper gastrointestinal subepithelial lesions (SELs) < 20 mm with on-site stereomicroscopic assessment. [AIM] This study is aimed at investigating the usefulness of EUS-TA combined with on-site stereomicr...
biopsy; upper gastrointestinal tract
1.18
156
Gastroenterology; Hepatology
Medicine
2,024
40,433,367
Molecular subtypes based on ferroptosis-related genes and tumor microenvironment infiltration characterization in small cell lung cancer.
Frontiers in immunology
Front Immunol
16
null
10.3389/fimmu.2025.1574434
eng
2,025
null
null
2,025
5
13
[BACKGROUND] Ferroptosis is an iron-dependent form of regulated cell death associated with cancer. However, the characteristics of ferroptosis in small cell lung cancer (SCLC) are still uncertain. This study aimed to explore the application value of ferroptosis-related genes (FRGs) classification in prognosis and chara...
SCLC; TME; ferroptosis; immunotherapy; molecular subtypes
1.941
259
Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,024
40,433,302
Digital natives: A systematic review of the digital health literacy and influencing factors among Chinese college students.
Digital health
Digit Health
11
null
10.1177/20552076251346006
eng
2,025
null
null
2,025
5
25
[OBJECTIVE] This study aimed to explore the current status of digital health literacy (DHL) among Chinese college students, and to summarize and analyze the related influencing factors. [METHODS] A systematic search was conducted in Web of Science, PubMed, EBSCO, Scopus, China National Knowledge Infrastructure, Wanfang...
Digital health literacy; college students; influencing factors; systematic review
0.874
39
Computer Science Applications; Health Informatics; Health Information Management; Health Policy
Computer Science; Health Professions; Medicine
2,024
40,433,070
Global and regional burden of congenital birth defects, 1990-2021: persistent healthcare disparities and emerging challenges from non-fatal health burden.
BMJ public health
BMJ Public Health
3
1
10.1136/bmjph-2024-001608
eng
2,025
null
null
2,025
5
26
[INTRODUCTION] Approximately 3%-6% of infants were born with congenital birth defects worldwide every year, which ranked as the third leading cause of deaths among the population under 20 years of age in 2021. [METHODS] By adopting the methodology from Global Burden of Disease Study 2021, we systematically analysed the...
Cross-Sectional Studies; Epidemiology; Public Health
null
null
null
null
null
40,432,869
Impact of the COVID-19 Pandemic on Buckle Fracture Treatment.
Journal of the Pediatric Orthopaedic Society of North America
J Pediatr Soc North Am
11
null
10.1016/j.jposna.2025.100162
eng
2,025
5
null
2,025
3
13
[BACKGROUND] Based on the existing consensus in the literature, we have coined a term at our institution to describe optimal treatment for distal radius buckle fractures: Buckle Evidence-based Strategic Treatment (BEST). BEST includes a single provider visit, education, a removable wrist brace/bandage, no additional fo...
BEST practices; COVID-19; Management of buckle fractures; Pediatric distal radius buckle fracture; Practice patterns
null
null
null
null
null
40,432,740
5-Aminolevulinic Acid-Mediated Metronomic Photodynamic Therapy for Mouse Mammary Tumors.
Yonago acta medica
Yonago Acta Med
68
2
10.33160/yam.2025.05.004
eng
2,025
5
null
2,025
4
18
[BACKGROUND] Metronomic photodynamic therapy (mPDT) is a novel cancer treatment strategy that uses low-dose light delivery and photosensitizers. 5-aminolevulinic acid (5-ALA), a precursor of protoporphyrin IX (PpIX) was previously used to treat human colorectal and esophageal cancer cells. However, no study has evaluat...
5-aminolevulinic acid; mammary tumor; metronomic photodynamic therapy; mouse; organic light-emitting diode
0.266
25
Medicine
Medicine
2,024
40,432,723
Effectiveness of biofeedback therapy on low anterior resection syndrome: a systemic review with meta-analysis.
Frontiers in medicine
Front Med (Lausanne)
12
null
10.3389/fmed.2025.1538114
eng
2,025
null
null
2,025
5
13
[BACKGROUND] As a series of bothersome bowel dysfunction symptoms, low anterior resection syndrome (LARS) has a high incidence after rectal cancer surgery, which grievously impairs health-related quality of life. There have been an increasing number of studies on biofeedback therapy (BFT) to recover intestinal function...
LARS; biofeedback; bowel function; low anterior resection syndrome; meta-analysis
0.962
102
Medicine
Medicine
2,024
40,432,686
Evaluation of Radiolucent Lesions in Cortices of Long Bones in Osteogenesis Imperfecta Patients.
Journal of the Pediatric Orthopaedic Society of North America
J Pediatr Soc North Am
9
null
10.1016/j.jposna.2024.100128
eng
2,024
11
null
2,024
10
9
[BACKGROUND] Osteogenesis imperfecta (OI), a rare genetic disorder of collagen synthesis and metabolism, is characterized by cortical bone thinning and decreased trabecular bone. We have noted individuals with OI develop radiolucent lesions in the cortices of the long bones and these have not been previously described....
Brittle bone disease; Osteogenesis imperfecta
null
null
null
null
null
40,432,509
In vitro apoptotic potential and ex vivo permeation analysis of ulipristal acetate loaded niosomes for management of uterine fibroids.
Journal of microencapsulation
J Microencapsul
null
null
10.1080/02652048.2025.2507639
eng
2,025
5
28
2,025
5
28
[AIM] To develop and optimise a niosomal formulation of ulipristal acetate (UPA) for enhanced cytotoxicity against uterine fibroids. [METHODS] Quality by Design, thin film hydration, dynamic light scattering, transmission electron microscopy, cytotoxicity assays, flow cytometry, reactive oxygen species (ROS) generation...
Drug delivery system; cancer chemotherapy; niosomes, uterine fibroids; reactive oxygen species; ulipristal acetate
0.507
91
Organic Chemistry; Pharmaceutical Science; Physical and Theoretical Chemistry; Bioengineering; Colloid and Surface Chemistry
Chemical Engineering; Chemistry; Pharmacology, Toxicology and Pharmaceutics
2,024
40,431,448
Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial.
Nutrients
Nutrients
17
10
10.3390/nu17101708
eng
2,025
5
18
2,025
5
18
[BACKGROUND] The disruption of the intestinal barrier and the imbalance of the gut microbiota (GM) seem to play a major role in the complex pathogenesis of irritable bowel syndrome (IBS). Specific microbial strains could improve the gut microenvironment, promoting anti-inflammatory pathways; similarly, vitamin D supple...
IBS; gut barrier; probiotic
1.473
243
Food Science; Nutrition and Dietetics
Agricultural and Biological Sciences; Nursing
2,024
40,430,227
The Effect of Pupil Size on Cone Contrast Sensitivity.
Life (Basel, Switzerland)
Life (Basel)
15
5
10.3390/life15050801
eng
2,025
5
17
2,025
5
17
[BACKGROUND] Measuring contrast sensitivity for each of the three cone types separately allows for a more precise and clinically valuable assessment of color vision. This study examined how pupil size affects cone contrast sensitivity (CCS). [METHODS] This study included 50 participants of equal gender. The mean age wa...
color vision; cone contrast sensitivity; pupil size; wavelength cone systems
0.824
69
Ecology, Evolution, Behavior and Systematics; Paleontology; Biochemistry, Genetics and Molecular Biology; Space and Planetary Science
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Earth and Planetary Sciences
2,024
40,430,149
Myokinetic Stretching Exercise Versus Post-Isometric Relaxation Combined with Traction in Patients with Cervical Radiculopathy-A Randomized Clinical Trial.
Life (Basel, Switzerland)
Life (Basel)
15
5
10.3390/life15050721
eng
2,025
4
29
2,025
4
29
[BACKGROUND] Cervical radiculopathy is one of the frequent musculoskeletal problems prevalent in the general population, characterized by neck pain radiating to the upper limb. This study investigated the effects of the myokinetic stretching technique versus post-isometric relaxation (PIR) exercises with mechanical tra...
cervical radiculopathy; cervical traction; stretching technique
0.824
69
Ecology, Evolution, Behavior and Systematics; Paleontology; Biochemistry, Genetics and Molecular Biology; Space and Planetary Science
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Earth and Planetary Sciences
2,024
40,428,344
A Series of Patients with Genodermatoses in a Reference Service for Rare Diseases: Results from the Brazilian Rare Genomes Project.
Genes
Genes (Basel)
16
5
10.3390/genes16050522
eng
2,025
4
29
2,025
4
29
[BACKGROUND/OBJECTIVES] Genodermatoses are genetic conditions with clinical symptoms manifesting in the skin and adjoining tissues, individually rare but comprising a large and heterogeneous group of disorders that represents 15% of genetic diseases. This article discusses the results of individuals with genodermatoses...
albinism; ectodermal dysplasia; genodermatoses; genome sequencing; ichthyosis; incontinentia pigmenti; rare diseases; tuberous sclerosis complex
0.858
103
Genetics; Genetics
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,428,301
Molecular Cloning and Heterologous Expression of the Mitochondrial ATP6 Gene from Kenaf (Hibiscus cannabinus) in Tobacco (Nicotiana tabacum).
Genes
Genes (Basel)
16
5
10.3390/genes16050479
eng
2,025
4
23
2,025
4
23
[BACKGROUND] The aim of this study was to develop a genetic transformation system to construct an overexpression vector for the mitochondrial gene atp6 in tobacco, thereby providing a foundation to investigate the functional roles of mitochondrial genes in this species. [METHODS] A full-length coding sequence (CDS) of ...
atp6; construction of overexpression vectors; cytoplasmic male sterility; kenaf; transformation
0.858
103
Genetics; Genetics
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,428,041
A Scoping Review of AI-Driven Digital Interventions in Mental Health Care: Mapping Applications Across Screening, Support, Monitoring, Prevention, and Clinical Education.
Healthcare (Basel, Switzerland)
Healthcare (Basel)
13
10
10.3390/healthcare13101205
eng
2,025
5
21
2,025
5
21
[BACKGROUND/OBJECTIVES] Artificial intelligence (AI)-enabled digital interventions are increasingly used to expand access to mental health care. This PRISMA-ScR scoping review maps how AI technologies support mental health care across five phases: pre-treatment (screening), treatment (therapeutic support), post-treatme...
AI-assisted psychotherapy; artificial intelligence; chatbots; conversational agents; digital mental health; large language models; machine learning; mental health screening; remote patient monitoring; scoping review
0.83
33
Health Policy
Medicine
2,024
40,428,025
Surrogate Trust in the Intensive Care Unit: What Can We Do Better?
Healthcare (Basel, Switzerland)
Healthcare (Basel)
13
10
10.3390/healthcare13101189
eng
2,025
5
20
2,025
5
20
[BACKGROUND/OBJECTIVES] Previous investigation into patients' trust in medical providers is largely limited to the outpatient setting, where increased trust is associated with improved adherence, satisfaction, and self-reported quality of life. Contrastingly, in the intensive care unit (ICU), patients are frequently in...
intensive care unit; surrogate; trust
0.83
33
Health Policy
Medicine
2,024
40,426,310
Comprehensive Evaluation of Treatment Patterns in Postmenopausal Patients with Osteoporosis without Fractures: Insights from Tertiary Care Institutions and Nationwide OMOP-CDM Data.
Endocrinology and metabolism (Seoul, Korea)
Endocrinol Metab (Seoul)
null
null
10.3803/EnM.2024.2252
eng
2,025
5
28
2,025
5
28
[BACKGROUND] Osteoporosis is a global health concern. Despite emerging treatment options for this condition, limited data are available on hospital practices in South Korea. This study addresses the need for a hospital network database that reflects changes in routine clinical practice for osteoporosis in a timely mann...
Drug prescriptions; Osteoporosis, postmenopausal
1.487
53
Endocrinology; Endocrinology, Diabetes and Metabolism
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,426,199
Demineralized bone matrix combined with concentrated growth factors promotes intervertebral fusion in a novel rat extreme lateral interbody fusion model.
Journal of orthopaedic surgery and research
J Orthop Surg Res
20
1
10.1186/s13018-025-05954-2
eng
2,025
5
27
2,025
5
27
[BACKGROUND] Whether demineralized bone matrix (DBM) combined with concentrated growth factors (CGF) can accelerate intervertebral fusion remains uncertain. This study developed a novel rat model for extreme lateral interbody fusion (XLIF) and evaluated the fusion outcomes of DBM combined with CGF using imaging and his...
Concentrated growth factor; Demineralized bone matrix; Intervertebral fusion; XLIF
0.877
75
Orthopedics and Sports Medicine; Surgery
Medicine
2,024
40,426,153
Assessing shear bond strength of various surface treatments of titanium alloy with high translucency monolithic zirconia.
BMC oral health
BMC Oral Health
25
1
10.1186/s12903-025-06240-7
eng
2,025
5
27
2,025
5
27
[OBJECTIVE] The purpose of this in vitro study was to investigate the shear bond strength of high translucent monolithic zirconia and titanium alloy (Ti6Al4V) after various surface treatments using resin cement. [MATERIALS AND METHODS] Ninety Ti6Al4V specimens were randomly allocated into six groups (n = 15 per group):...
Anodize; Laser confocal microscopy; Resin cement; Shear bond strength; Titanium alloy; Zirconia
0.843
80
Dentistry
Dentistry
2,024
40,426,131
Prevalence of osteoarthritis and clinical outcomes in patients with fractures of the tibial plateau - medium- and long-term analysis.
BMC musculoskeletal disorders
BMC Musculoskelet Disord
26
1
10.1186/s12891-025-08786-7
eng
2,025
5
27
2,025
5
27
[BACKGROUND] The incidence of post-traumatic osteoarthritis (OA) following intraarticular knee fractures has been estimated to be relatively high but it varies substantially between different reports. In this study we sought to assess the prevalence of radiographic knee OA secondary to tibial plateau fractures (TPF). T...
Knee; Osteoarthritis; Outcome; Tibial plateau fracture
0.805
131
Orthopedics and Sports Medicine; Rheumatology
Medicine
2,024
40,426,116
The mediating effect of maternal blood lipids on the association between maternal exposure to PM2.5 and birth weight: a retrospective birth cohort study in Zhejiang, China.
Lipids in health and disease
Lipids Health Dis
24
1
10.1186/s12944-025-02614-6
eng
2,025
5
27
2,025
5
27
[BACKGROUND] Maternal PM2.5 exposure and lipid levels during pregnancy were independently detected associated with birth weight. Potential mediating factors still remain unclear. [METHODS] This study aimed to examine the association of maternal PM2.5 exposure and birth weight, and explore the potential mediation effect...
Birth weight; Maternal lipids; Mediation effect; PM2.5
1.24
105
Biochemistry; Clinical Biochemistry; Endocrinology; Endocrinology, Diabetes and Metabolism
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,425,956
Elevated CEP72 expression facilitates the progression of hepatocellular carcinoma and is associated with unfavorable outcomes.
Discover oncology
Discov Oncol
16
1
10.1007/s12672-025-02540-0
eng
2,025
5
27
2,025
5
27
[INTRODUCTION] The specific roles and mechanisms underlying the involvement of centrosomal protein 72 (CEP72) in hepatocellular carcinoma (HCC) development are not fully understood. Thus, this study aimed to explore the influence of CEP72 on the prognosis of HCC and elucidate the underlying mechanisms involved. [MATERI...
CEP72; Hepatocellular carcinoma; Hsa-miR-139-5p; Prognosis
0.88
47
Endocrine and Autonomic Systems; Endocrinology; Endocrinology, Diabetes and Metabolism; Oncology; Cancer Research
Biochemistry, Genetics and Molecular Biology; Medicine; Neuroscience
2,024
40,425,863
Laparoscopic surgery in acute perforated gastroduodenal ulcers: an underutilized technique despite favorable short-term outcomes.
Surgical endoscopy
Surg Endosc
39
7
10.1007/s00464-025-11855-6
eng
2,025
7
null
2,025
5
27
[BACKGROUND] Acute perforation is a serious complication associated with peptic ulcer disease (PUD). Laparotomy remains the traditional operative intervention for repair. However, the laparoscopic approach has gained popularity over the last two decades. This study aims to evaluate the 30-day outcomes of laparoscopic a...
Complicated gastroduodenal ulcer; Gastroduodenal ulcer perforation; Laparoscopic vs. open repair; Peptic ulcer disease
1.023
178
Surgery
Medicine
2,024
40,425,438
Eradication rate after debridement, antibiotics, and implant retention (DAIR), 1.5-stage revision or 2-stage revision in periprosthetic ankle joint infection: A systematic review.
Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
Foot Ankle Surg
null
null
10.1016/j.fas.2025.05.006
eng
2,025
5
14
2,025
5
14
[OBJECTIVE] The management of periprosthetic joint infection (PJI) after total ankle replacement (TAR) may be challenging. Our aim was to define the eradication rate and limits of some of the surgical procedures commonly performed to treat acute and chronic PJI after TAR. [METHODS] For this PRISMA-compliant systematic ...
1.5-stage; 2-stage; Ankle replacement; DAIR; Infection; Revision
0.992
56
Orthopedics and Sports Medicine
Medicine
2,024
40,425,384
Clinical outcomes by histologic pattern of early-stage metaplastic breast cancer: A single-institution retrospective study.
Clinical breast cancer
Clin Breast Cancer
null
null
10.1016/j.clbc.2025.04.022
eng
2,025
5
3
2,025
5
3
[PURPOSE] Metaplastic breast cancer (MpBC) is a rare, aggressive type of breast cancer composed of several histologic patterns. This study evaluated outcomes among the MpBC histologic patterns, which include spindle cell/sarcomatous, squamous, heterologous mesenchymal, and mixed. [PATIENTS AND METHODS] A retrospective ...
Metaplastic carcinoma; Neoadjuvant chemotherapy; Overall survival; Recurrence-free survival; Residual cancer burden
1.018
85
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,425,342
In Vitro Evaluation of the Dual Pharmacological Action of Vitamin D3 as Cardio-protectant and Anti-cancer Agent.
Anticancer research
Anticancer Res
45
6
10.21873/anticanres.17608
eng
2,025
6
null
null
null
null
[BACKGROUND/AIM] Doxorubicin (DOX) is a potent and widely used chemotherapeutic; however, DOX-induced cardiotoxicity (DIC) remains a major clinical challenge. This study evaluated the cardio-protective and cytotoxic activities of vitamin D3 in combination with DOX and as a single agent. [MATERIALS AND METHODS] Immortal...
Doxorubicin; cardiotoxicity; cholecalciferol; cytotoxicity; difficult-to-treat cancer; drug-drug interaction
null
null
null
null
null
40,425,253
Taking action, return-to-work strategies used by Iranian cancer survivors: a qualitative study.
BMJ open
BMJ Open
15
5
10.1136/bmjopen-2024-097932
eng
2,025
5
26
2,025
5
26
[OBJECTIVES] The transition back to work after cancer is a significant milestone for many survivors, affecting their financial stability, psychological well-being and overall quality of life. Return-to-work (RTW) process is often complicated by lingering physical and cognitive impairments, changes in self-identity and ...
Adult oncology; Nursing Care; Nursing research; OCCUPATIONAL INDUSTRIAL MEDICINE; REHABILITATION MEDICINE
1.016
176
Medicine
Medicine
2,024
40,425,244
Development of risk prediction equations for 5-year diabetes incidence using Japanese health check-up data: a retrospective cohort study.
BMJ open
BMJ Open
15
5
10.1136/bmjopen-2024-097005
eng
2,025
5
26
2,025
5
26
[OBJECTIVES] This study aimed to develop risk prediction equations for the 5-year incidence of diabetes among the Japanese population using health check-up data. We hypothesised that demographic and laboratory data from health check-ups could predict diabetes onset with high accuracy. [DESIGN] Retrospective cohort stud...
Diabetes Mellitus, Type 2; PREVENTIVE MEDICINE; Risk Factors
1.016
176
Medicine
Medicine
2,024
40,424,990
Interactions of Probiotics with the Immune Cells of Patients with COVID-19 Pneumonia.
Journal of innate immunity
J Innate Immun
17
1
10.1159/000545873
eng
2,025
null
null
2,025
5
27
[INTRODUCTION] In severe COVID-19, excessive cytokine release may be driven by SARS-CoV-2. We investigated the modulatory effect of probiotics taking into consideration direct interaction with the immune gut cells. [METHODS] Fifty-five patients with confirmed COVID-19 infection were classified by the presence of acute ...
COVID-19; Probiotics; Toll-like receptor 2; Toll-like receptor 4
1.2
86
Immunology and Allergy
Medicine
2,024
40,424,564
Randomized Phase II Study of Concurrent Versus Sequential Pembrolizumab in Combination With Chemoradiation in Locally Advanced Head and Neck Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
J Clin Oncol
43
23
10.1200/JCO-24-01580
eng
2,025
8
10
2,025
5
27
[PURPOSE] The optimal timing of pembrolizumab with chemoradiation (CRT) in locally advanced (LA) head and neck squamous cell carcinoma (HNSCC) is unknown. [PATIENTS AND METHODS] Our phase II trial randomly assigned patients 1:1 to concurrent pembrolizumab (200 mg once every 3 weeks × 8) starting 1 week before CRT (cisp...
null
11.205
646
Cancer Research; Medicine; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,424,451
NR2F6 promotes the malignant progression of neuroblastoma as an indicator of poor prognosis.
PloS one
PLoS One
20
5
10.1371/journal.pone.0324334
eng
2,025
null
null
2,025
5
27
[BACKGROUND] NR2F6 is an orphan nuclear receptor with dual tumorigenic activity in the immune system and tumor cells, playing an essential role in tumor differentiation and immunity. This study aimed to investigate the expression level of NR2F6 in various tumors and its effect on neuroblastoma (NB). [METHODS] We evalua...
null
0.803
467
Multidisciplinary
Multidisciplinary
2,024
40,424,321
Seasonal pattern of preterm birth in the Netherlands: A population-based retrospective cohort study.
PloS one
PLoS One
20
5
10.1371/journal.pone.0324873
eng
2,025
null
null
2,025
5
27
[BACKGROUND] Prior research has demonstrated the impact of environmental influences, including seasonal patterns, as determinants of preterm birth, although relationships vary. This study aims to determine whether there is an association between month of conception and preterm birth or gestational age at birth in the N...
null
0.803
467
Multidisciplinary
Multidisciplinary
2,024
40,423,777
Multitracer comparison of gold standard PSMA-PET/CT with [68]Ga-FAPI and [18]F-FDG in high-risk prostate cancer: a proof-of-concept study.
European journal of nuclear medicine and molecular imaging
Eur J Nucl Med Mol Imaging
null
null
10.1007/s00259-025-07352-6
eng
2,025
5
27
2,025
5
27
[PURPOSE] The aim of this study was to, evaluate the diagnostic accuracy of [[68]Ga]Ga-FAPI-46 positron emission tomography (PET)/computed tomography (CT) in high-risk prostate cancer (PC) compared to [[18]F]PSMA / [[68]Ga]Ga- PSMA- and [[18]F]FDG- PET/CT as well as multiparametric magnetic resonance imaging (MRI). [MA...
Fibroblast activation protein; Fluorodeoxyglucose F18; Positron emission tomography; Prostate neoplasms; Prostate-specific membrane antigen
2.392
192
Medicine; Radiology, Nuclear Medicine and Imaging
Medicine
2,024
40,423,565
Implementation of a Checklist for Surgical Inpatient Rounds: An Observational Cohort Study.
Journal of patient safety
J Patient Saf
21
6
10.1097/PTS.0000000000001371
eng
2,025
9
1
2,025
5
28
[BACKGROUND] The surgical ward round is the linchpin of inpatient care. Despite this, it is often pressured by external forces such as theatre times, on-call demands, or outpatient clinics. Checklists have been successful in saving lives, particularly in the operating room. Some of this work has translated to the surgi...
checklists; patient safety; surgery
0.869
49
Leadership and Management; Public Health, Environmental and Occupational Health
Medicine; Nursing
2,024
40,422,585
Hypertensive Emergency and Atypical Hemolytic Uremic Syndrome Associated with Cocaine Use: A Diagnostic and Therapeutic Challenge.
Diseases (Basel, Switzerland)
Diseases
13
5
10.3390/diseases13050153
eng
2,025
5
15
2,025
5
15
[BACKGROUND] Atypical hemolytic uremic syndrome (HUS) is a rare form of thrombotic microangiopathy (TMA) characterized by complement dysregulation. Cocaine use has been reported to be a potential trigger of TMA; however, the underlying mechanisms remain poorly elucidated. Proposed hypotheses include direct endothelial ...
acute kidney injury; atypical hemolytic uremic syndrome; cocaine; thrombotic microangiopathy
0.851
26
Medicine
Medicine
2,024
40,421,754
Diagnosis of Drug-Resistant Tuberculosis: Rapid Evaluation of Drug Susceptibility with Nanopore Targeted Sequencing.
Clinical chemistry
Clin Chem
71
8
10.1093/clinchem/hvaf061
eng
2,025
8
1
null
null
null
[BACKGROUND] Whole-genome sequencing (WGS) has limitations in clinical diagnostics due to host DNA interference and lower pathogen load in clinical samples compared to cultured isolates, which reduce the effective sequencing depth and compromise the detection of resistance-associated mutations. As our understanding of ...
null
1.345
248
Biochemistry; Clinical Biochemistry; Medicine
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,421,709
Treatment With Phosphodiesterase 5 Inhibitors and Long-Term Outcomes in Patients Undergoing Coronary Angiography and Cardiac Catheterization.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography Interventions
Catheter Cardiovasc Interv
106
2
10.1002/ccd.31624
eng
2,025
8
null
2,025
5
27
[BACKGROUND] The effects of phosphodiesterase 5 (PDE5) inhibitors on the incidence of long-term outcomes in patients with cardiovascular disease are not well understood. [OBJECTIVE] We studied the association between PDE5 inhibitor therapy and the incidence of adverse cardiovascular major adverse cardiovascular events ...
cardiac catheterization; coronary angiography; major adverse cardiovascular events; outcomes; phosphodiesterase 5 inhibitors
1.01
134
Cardiology and Cardiovascular Medicine; Medicine; Radiology, Nuclear Medicine and Imaging
Medicine
2,024
40,421,703
Percutaneous Coronary Intervention Outcomes for Chronic Total Occlusion in Patients on Dialysis: Analysis of the Japanese CTO-PCI Expert Registry.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography Interventions
Catheter Cardiovasc Interv
106
2
10.1002/ccd.31622
eng
2,025
8
null
2,025
5
27
[BACKGROUND] Patients undergoing dialysis are at a high risk of cardiovascular death, and the prevalence of coronary complex lesions is high. [AIMS] This study aimed to analyze the characteristics, outcomes, and adverse events of chronic total occlusion (CTO)-percutaneous coronary intervention (PCI) in patients undergo...
calcification; chronic total occlusion; patients undergoing dialysis; percutaneous coronary intervention
1.01
134
Cardiology and Cardiovascular Medicine; Medicine; Radiology, Nuclear Medicine and Imaging
Medicine
2,024
40,421,496
Enhancing cardiovascular screening in master athletes: the role of exercise stress echocardiography.
Minerva cardiology and angiology
Minerva Cardiol Angiol
null
null
10.23736/S2724-5683.25.06747-X
eng
2,025
5
27
2,025
5
27
[BACKGROUND] Cardiovascular (CV) disease is a significant risk even among seemingly healthier populations like master athletes, who face unique CV challenges due to their advanced age and high-intensity physical activities. Exercise stress echocardiography (ESE) has emerged as a valuable diagnostic tool to detect exerc...
null
0.405
30
Cardiology and Cardiovascular Medicine
Medicine
2,024
40,421,443
Oculomotor deficits in children with sensory processing difficulties.
The British journal of occupational therapy
Br J Occup Ther
88
6
10.1177/03080226251321342
eng
2,025
6
null
2,025
2
23
[BACKGROUND] Atypically developing children often present with a variety of sensory processing difficulties which have been proposed to reflect abnormal development of pathways integrating sensation and action. A brain system in which the process of sensorimotor integration is particularly well understood is the oculom...
ADHD; ASD; developmental coordination disorder; sensory integration theory; sensory processing disorder
0.429
56
Occupational Therapy
Health Professions
2,024
40,421,306
Treatment pathways and rebound-rate of prehospital viral croup attacks-data from a prehospital pediatric physician led emergency service-a prospective observational follow-up study.
Frontiers in pediatrics
Front Pediatr
13
null
10.3389/fped.2025.1544480
eng
2,025
null
null
2,025
5
12
[INTRODUCTION] Respiratory illnesses, often caused by upper or lower airway obstruction, represent one of the most common pediatric emergencies. Croup syndrome is the most frequent cause of inspiratory stridor. The study aims to record the incidence, current treatment, and further care measures. Additionally feasibilit...
croup; emergency medical services; pediatric emergency medicine; prehospital/EMS; respiratory diseases
0.738
83
Pediatrics, Perinatology and Child Health
Medicine
2,024
40,421,093
Diagnostic accuracy of artificial intelligence based on imaging data for predicting distant metastasis of colorectal cancer: a systematic review and meta-analysis.
Frontiers in oncology
Front Oncol
15
null
10.3389/fonc.2025.1558915
eng
2,025
null
null
2,025
5
12
[BACKGROUND] Colorectal cancer is the third most common malignant tumor with the third highest incidence rate. Distant metastasis is the main cause of death in colorectal cancer patients. Early detection and prognostic prediction of colorectal cancer has improved with the widespread use of artificial intelligence techn...
CT; MR; artificial intelligence; colorectal cancer; deep learning; distant metastasis; machine learning; ultrasound
1.075
156
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,420,676
Five-Year Evaluation of Students' Profiles and Professional Perspectives in an Innovative Dental Education Modality: A Mixed-Methods Approach.
European journal of dental education : official journal of the Association for Dental Education in Europe
Eur J Dent Educ
null
null
10.1111/eje.13128
eng
2,025
5
27
2,025
5
27
[INTRODUCTION] This study explored the effects of a novel dental education modality (evening enrolment) on the graduating dental students' profiles within a public university setting, encompassing both their curricular experiences and professional perspectives. [MATERIALS AND METHODS] This cross-sectional observational...
assessment; curriculum; dental education; perception; public policy
0.671
58
Dentistry; Education
Dentistry; Social Sciences
2,024
40,420,611
Erector spinae plane block (ESPB) vs. pericapsular nerve group (PENG) block in total hip arthroplasty in elderly patients: a randomized, double-blinded, controlled trial.
Anaesthesiology intensive therapy
Anaesthesiol Intensive Ther
57
1
10.5114/ait/203170
eng
2,025
5
15
2,025
5
15
[INTRODUCTION] This study evaluated the efficacy of ultrasound-guided erector spinae plane block (ESPB) and pericapsular nerve group (PENG) block under spinal anesthesia for postoperative analgesia in elderly patients undergoing total hip arthroplasty. [MATERIAL AND METHODS] In this randomized, controlled, double-blind...
ESPB; PENG block; erector spinae plane block; pericapsular nerve group block; total hip arthroplasty
0.472
37
Anesthesiology and Pain Medicine; Critical Care and Intensive Care Medicine; Medicine
Medicine
2,024
40,420,290
Belief in a just world or belief in just others? a study on the object of belief in a just world.
BMC psychology
BMC Psychol
13
1
10.1186/s40359-025-02897-5
eng
2,025
5
27
2,025
5
27
[BACKGROUND] While belief in a just world has been extensively studied, the object of this belief still requires further specification. This study distinguishes two sources of uncertainty in future returns-nature and other people-and investigates whether belief in a just world is specifically directed toward human-sour...
Adaptiveness; Belief in a just world; Investment game; Uncertainty
1.03
49
Medicine; Psychology
Medicine; Psychology
2,024
40,420,265
Is injectable platelet-rich fibrin really effective in alveolar osteitis? a randomised controlled clinical trial.
BMC oral health
BMC Oral Health
25
1
10.1186/s12903-025-06257-y
eng
2,025
5
26
2,025
5
26
[BACKGROUND] Alveolar osteitis(AO) is an inflammatory and painful condition that occurs due to distruption of the fibrin matrix within the extraction socket following tooth extraction. This study investigates the effectiveness of I-PRF in reducing pain in AO patients compared to conventional treatment. [MATERIALS AND M...
Alveolar osteitis; Injectable platelet-rich fibrin; Pain
0.843
80
Dentistry
Dentistry
2,024