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22,447,396
Are common NOD2 risk variants in African Americans with Crohn 's disease due exclusively to recent Caucasian admixture?
{ "contexts": [ "Crohn's disease (CD) is highly heritable. NOD2 has emerged as the main susceptibility gene among individuals of European ancestry; however, NOD2 does not appear to contribute to CD susceptibility among many non-European populations. Today's African American (AA) population represents an admixture...
The NOD2 gene is a risk for CD in AAs, although the allele frequencies and the attributable risk are much lower compared with Caucasians. The risk alleles are not seen in the West African population, suggesting that the risk for CD contributed by NOD2 among AAs is due exclusively to recent European admixture.
yes
pub_med_qa40000
[ { "content": "ํฌ๋ก ๋ณ‘์„ ์•“๊ณ  ์žˆ๋Š” ์•„ํ”„๋ฆฌ์นด๊ณ„ ๋ฏธ๊ตญ์ธ์˜ ์ผ๋ฐ˜์ ์ธ NOD2 ์œ„ํ—˜ ๋ณ€์ด๋Š” ์ตœ๊ทผ ๋ฐฑ์ธ ํ˜ผํ•ฉ๋ฌผ์—๋งŒ ๊ธฐ์ธํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\nํฌ๋ก ๋ณ‘(CD)์€ ์œ ์ „์„ฑ์ด ๋งค์šฐ ๋†’์Šต๋‹ˆ๋‹ค. NOD2๋Š” ์œ ๋Ÿฝ ํ˜ˆํ†ต์„ ๊ฐ€์ง„ ๊ฐœ์ธ๋“ค ์‚ฌ์ด์—์„œ ์ฃผ์š” ๊ฐ์ˆ˜์„ฑ ์œ ์ „์ž๋กœ ๋ถ€์ƒํ–ˆ์ง€๋งŒ, NOD2๋Š” ๋งŽ์€ ๋น„์œ ๋Ÿฝ์ธ๋“ค ์‚ฌ์ด์—์„œ CD ๊ฐ์ˆ˜์„ฑ์— ๊ธฐ์—ฌํ•˜์ง€ ์•Š๋Š” ๊ฒƒ์œผ๋กœ ๋ณด์ž…๋‹ˆ๋‹ค. ์˜ค๋Š˜๋‚  ์•„ํ”„๋ฆฌ์นด๊ณ„ ๋ฏธ๊ตญ์ธ(AA) ์ธ๊ตฌ๋Š” ์„œ์•„ํ”„๋ฆฌ์นด๊ณ„(80%)์™€ ์œ ๋Ÿฝ๊ณ„(20%) ํ˜ˆํ†ต์˜ ํ˜ผํ•ฉ์ฒด๋ฅผ ๋‚˜ํƒ€๋ƒ…๋‹ˆ๋‹ค. ์œ ์ „์žํ˜• ๊ธฐ๋ฐ˜ ๋„๊ตฌ๊ฐ€ ...
The NOD2 gene is a risk for CD in AAs, although the allele frequencies and the attributable risk are much lower compared with Caucasians. The risk alleles are not seen in the West African population, suggesting that the risk for CD contributed by NOD2 among AAs is due exclusively to recent European admixture.
NOD2 ์œ ์ „์ž๋Š” ๋ฐฑ์ธ์— ๋น„ํ•ด ๋Œ€๋ฆฝ ์œ ์ „์ž ๋นˆ๋„์™€ ๊ท€์ธ ์œ„ํ—˜์ด ํ›จ์”ฌ ๋‚ฎ์ง€๋งŒ, AA์—์„œ CD์˜ ์œ„ํ—˜์€ ์—ฌ์ „ํžˆ ๋‚ฎ์Šต๋‹ˆ๋‹ค. ์„œ์•„ํ”„๋ฆฌ์นด ์ธ๊ตฌ์—์„œ๋Š” ์ด๋Ÿฌํ•œ ์œ„ํ—˜ ๋Œ€๋ฆฝ ์œ ์ „์ž๊ฐ€ ๋‚˜ํƒ€๋‚˜์ง€ ์•Š์œผ๋ฉฐ, ์ด๋Š” AA์—์„œ NOD2๊ฐ€ ๊ธฐ์—ฌํ•˜๋Š” CD์˜ ์œ„ํ—˜์ด ์ „์ ์œผ๋กœ ์ตœ๊ทผ ์œ ๋Ÿฝ ํ˜ผํ•ฉ๋ฌผ์— ๊ธฐ์ธํ•œ๋‹ค๋Š” ๊ฒƒ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
22,431,347
Does endovascular stent provide more effective early relief of SVC obstruction compared to balloon angioplasty?
{ "contexts": [ "To determine whether superior vena cava (SVC) stent implantation is superior to balloon angioplasty for relieving SVC stenosis.", "SVC stent and balloon dilation have been used as treatment for SVC stenosis. Although safe and effective, outcome data comparing the two methods are limited.", ...
SVC stent implantation is more effective than angioplasty in relief of SVC obstruction. Weight and age are not risk factors for early re-intervention.
yes
pub_med_qa40001
[ { "content": "ํ˜ˆ๊ด€ ๋‚ด ์Šคํ…ํŠธ๊ฐ€ ํ’์„  ํ˜ˆ๊ด€ ์„ฑํ˜•์ˆ ์— ๋น„ํ•ด SVC ํ์‡„๋ฅผ ์กฐ๊ธฐ์— ๋” ํšจ๊ณผ์ ์œผ๋กœ ์™„ํ™”ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "user" }, { "content": "ํ˜ˆ๊ด€ ๋‚ด ์Šคํ…ํŠธ๊ฐ€ ํ’์„  ํ˜ˆ๊ด€ ์„ฑํ˜•์ˆ ์— ๋น„ํ•ด SVC ํ์‡„๋ฅผ ์กฐ๊ธฐ์— ๋” ํšจ๊ณผ์ ์œผ๋กœ ์™„ํ™”ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "passage" } ]
SVC stent implantation is more effective than angioplasty in relief of SVC obstruction. Weight and age are not risk factors for early re-intervention.
SVC ์Šคํ…ํŠธ ์‚ฝ์ž…์€ ํ˜ˆ๊ด€ ์„ฑํ˜•์ˆ ๋ณด๋‹ค SVC ํ์‡„ ์™„ํ™”์— ๋” ํšจ๊ณผ์ ์ž…๋‹ˆ๋‹ค. ์ฒด์ค‘๊ณผ ๋‚˜์ด๋Š” ์กฐ๊ธฐ ์žฌ๊ฐœ์ž…์˜ ์œ„ํ—˜ ์š”์†Œ๊ฐ€ ์•„๋‹™๋‹ˆ๋‹ค.
22,432,063
Do specific chromosomal IG translocations have different prognoses in chronic lymphocytic leukemia?
{ "contexts": [ "Chromosomal translocations are usually analyzed as a single entity, and are associated with a poor outcome in chronic lymphocytic leukemia. Translocations involving immunoglobulin genes are recurrent, but uncommon (<5%), and their individual prognosis is not clear. The two most frequent partners ...
BCL2-CLL.S express CD5 and lack expression of CD38, and have a Matutes score โ‰ฅ4, frequent trisomy 12, no ATM and 6q deletions, and a mutated IGHV status. Compared to BCL3-CLLs, BCL2-CLLs are much less aggressive; indicating that identifying individual translocations and cytogenetic partners would allow improved patient...
yes
pub_med_qa40002
[ { "content": "๋งŒ์„ฑ ๋ฆผํ”„๊ตฌ์„ฑ ๋ฐฑํ˜ˆ๋ณ‘์—์„œ ํŠน์ • ์—ผ์ƒ‰์ฒด IG ์ „์œ„๋Š” ์˜ˆํ›„๊ฐ€ ๋‹ค๋ฅธ๊ฐ€์š”?", "role": "user" }, { "content": "๋งŒ์„ฑ ๋ฆผํ”„๊ตฌ์„ฑ ๋ฐฑํ˜ˆ๋ณ‘์—์„œ ํŠน์ • ์—ผ์ƒ‰์ฒด IG ์ „์œ„๋Š” ์˜ˆํ›„๊ฐ€ ๋‹ค๋ฅธ๊ฐ€์š”?", "role": "passage" } ]
BCL2-CLL.S express CD5 and lack expression of CD38, and have a Matutes score โ‰ฅ4, frequent trisomy 12, no ATM and 6q deletions, and a mutated IGHV status. Compared to BCL3-CLLs, BCL2-CLLs are much less aggressive; indicating that identifying individual translocations and cytogenetic partners would allow improved patient...
BCL2-CLL.S๋Š” CD5๋ฅผ ๋ฐœํ˜„ํ•˜๊ณ  CD38์˜ ๋ฐœํ˜„์ด ์—†์œผ๋ฉฐ, Matutes ์ ์ˆ˜ โ‰ฅ 4, ๋นˆ๋ฒˆํ•œ ์‚ผ์ถœ์ˆ  12, ATM ๋ฐ 6q ๊ฒฐ์† ์—†์Œ, ๋Œ์—ฐ๋ณ€์ด IGHV ์ƒํƒœ๋ฅผ ๊ฐ€์ง€๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. BCL3-CLL์— ๋น„ํ•ด BCL2-CLL์€ ํ›จ์”ฌ ๋œ ๊ณต๊ฒฉ์ ์ด๋ฉฐ, ์ด๋Š” ๊ฐœ๋ณ„ ์ „์œ„์™€ ์„ธํฌ์œ ์ „ํ•™์  ํŒŒํŠธ๋„ˆ๋ฅผ ์‹๋ณ„ํ•˜๋Š” ๊ฒƒ์ด ํ™˜์ž ๊ณ„์ธตํ™”๋ฅผ ๊ฐœ์„ ํ•  ์ˆ˜ ์žˆ์Œ์„ ๋‚˜ํƒ€๋ƒ…๋‹ˆ๋‹ค.
22,448,228
Does the adaptor molecule Nck localize the WAVE complex to promote actin polymerization during CEACAM3-mediated phagocytosis of bacteria?
{ "contexts": [ "CEACAM3 is a granulocyte receptor mediating the opsonin-independent recognition and phagocytosis of human-restricted CEACAM-binding bacteria. CEACAM3 function depends on an intracellular immunoreceptor tyrosine-based activation motif (ITAM)-like sequence that is tyrosine phosphorylated by Src fam...
Our results provide novel mechanistic insight into CEACAM3-initiated phagocytosis. We suggest that the CEACAM3 ITAM-like sequence is optimized to co-ordinate a minimal set of cellular factors needed to efficiently trigger actin-based lamellipodial protrusions and rapid pathogen engulfment.
yes
pub_med_qa40003
[ { "content": "์–ด๋Œ‘ํ„ฐ ๋ถ„์ž Nck๋Š” CEACAM3 ๋งค๊ฐœ ๋ฐ•ํ…Œ๋ฆฌ์•„์˜ ์‹๊ท  ์ž‘์šฉ ๋™์•ˆ ์•กํ‹ด ์ค‘ํ•ฉ์„ ์ด‰์ง„ํ•˜๊ธฐ ์œ„ํ•ด WAVE ๋ณตํ•ฉ์ฒด๋ฅผ ๊ตญ์†Œํ™”ํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\nCEACAM3๋Š” ์ธ๊ฐ„ ์ œํ•œ CEACAM ๊ฒฐํ•ฉ ๋ฐ•ํ…Œ๋ฆฌ์•„์˜ ์˜ต์†Œ๋‹Œ ๋น„์˜์กด์  ์ธ์‹ ๋ฐ ์‹์„ธํฌ ์ž‘์šฉ์„ ๋งค๊ฐœํ•˜๋Š” ๊ณผ๋ฆฝ๊ตฌ ์ˆ˜์šฉ์ฒด์ž…๋‹ˆ๋‹ค. CEACAM3์˜ ๊ธฐ๋Šฅ์€ ์ˆ˜์šฉ์ฒด ๊ฒฐํ•ฉ ์‹œ Src ๊ณ„์—ด ํ‚ค๋‚˜์ œ์— ์˜ํ•ด ์ธ์‚ฐํ™”๋˜๋Š” ์„ธํฌ ๋‚ด ๋ฉด์—ญ์ˆ˜์šฉ์ฒด ํ‹ฐ๋กœ์‹  ๊ธฐ๋ฐ˜ ํ™œ์„ฑํ™” ๋ชจํ‹ฐํ”„(ITAM) ์œ ์‚ฌ ์„œ์—ด์— ์˜์กดํ•ฉ๋‹ˆ๋‹ค. ์ธ์‚ฐํ™”๋œ ITAM ์œ ์‚ฌ ...
Our results provide novel mechanistic insight into CEACAM3-initiated phagocytosis. We suggest that the CEACAM3 ITAM-like sequence is optimized to co-ordinate a minimal set of cellular factors needed to efficiently trigger actin-based lamellipodial protrusions and rapid pathogen engulfment.
์šฐ๋ฆฌ์˜ ๊ฒฐ๊ณผ๋Š” CEACAM3์— ์˜ํ•ด ์œ ๋ฐœ๋œ ์‹์„ธํฌ์ž‘์šฉ์— ๋Œ€ํ•œ ์ƒˆ๋กœ์šด ๊ธฐ๊ณ„๋ก ์  ํ†ต์ฐฐ์„ ์ œ๊ณตํ•ฉ๋‹ˆ๋‹ค. ์šฐ๋ฆฌ๋Š” CEACAM3 ITAM ์œ ์‚ฌ ์„œ์—ด์ด ์•กํ‹ด ๊ธฐ๋ฐ˜์˜ ๋ผ๋ฉœ๋ฆฌํฌ๋””์–ผ ๋Œ์ถœ๋ถ€์™€ ๋น ๋ฅธ ๋ณ‘์›์ฒด ์‚ผํ‚ด์„ ํšจ์œจ์ ์œผ๋กœ ์œ ๋ฐœํ•˜๋Š” ๋ฐ ํ•„์š”ํ•œ ์ตœ์†Œํ•œ์˜ ์„ธํฌ ์ธ์ž ์„ธํŠธ๋ฅผ ์กฐ์ •ํ•˜๋„๋ก ์ตœ์ ํ™”๋˜์—ˆ๋‹ค๊ณ  ์ œ์•ˆํ•ฉ๋‹ˆ๋‹ค.
22,448,229
Does ginkgo biloba respond to herbivory by activating early signaling and direct defenses?
{ "contexts": [ "Ginkgo biloba (Ginkgoaceae) is one of the most ancient living seed plants and is regarded as a living fossil. G. biloba has a broad spectrum of resistance or tolerance to many pathogens and herbivores because of the presence of toxic leaf compounds. Little is known about early and late events occ...
By studying early and late responses of G. biloba to herbivory, we provided the first evidence that this "living fossil" plant responds to herbivory with the same defense mechanisms adopted by the most recent angiosperms.
yes
pub_med_qa40004
[ { "content": "์€ํ–‰๋‚˜๋ฌด๋Š” ์ดˆ๊ธฐ ์‹ ํ˜ธ์™€ ์ง์ ‘ ๋ฐฉ์–ด๋ฅผ ํ™œ์„ฑํ™”ํ•˜์—ฌ ์ดˆ์‹๋™๋ฌผ์— ๋ฐ˜์‘ํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์€ํ–‰๋‚˜๋ฌด๋Š” ์ดˆ๊ธฐ ์‹ ํ˜ธ์™€ ์ง์ ‘ ๋ฐฉ์–ด๋ฅผ ํ™œ์„ฑํ™”ํ•˜์—ฌ ์ดˆ์‹๋™๋ฌผ์— ๋ฐ˜์‘ํ•ฉ๋‹ˆ๊นŒ?", "role": "passage" } ]
By studying early and late responses of G. biloba to herbivory, we provided the first evidence that this "living fossil" plant responds to herbivory with the same defense mechanisms adopted by the most recent angiosperms.
์ดˆ์‹๋™๋ฌผ์— ๋Œ€ํ•œ G. biloba์˜ ์ดˆ๊ธฐ ๋ฐ ํ›„๊ธฐ ๋ฐ˜์‘์„ ์—ฐ๊ตฌํ•จ์œผ๋กœ์จ, ์šฐ๋ฆฌ๋Š” ์ด "์‚ด์•„์žˆ๋Š” ํ™”์„" ์‹๋ฌผ์ด ๊ฐ€์žฅ ์ตœ๊ทผ์˜ ์†์”จ์‹๋ฌผ์—์„œ ์ฑ„ํƒํ•œ ๊ฒƒ๊ณผ ๋™์ผํ•œ ๋ฐฉ์–ด ๋ฉ”์ปค๋‹ˆ์ฆ˜์œผ๋กœ ์ดˆ์‹๋™๋ฌผ์— ๋ฐ˜์‘ํ•œ๋‹ค๋Š” ์ฒซ ๋ฒˆ์งธ ์ฆ๊ฑฐ๋ฅผ ์ œ๊ณตํ–ˆ์Šต๋‹ˆ๋‹ค.
22,438,565
Does gender influence the class III and V ฮฒ-tubulin ability to predict poor outcome in colorectal cancer?
{ "contexts": [ "Colorectal cancer is one of the deadliest diseases in Western countries. To predict the outcome of therapy, we assessed the role of class III (TUBB3) and class V ฮฒ-tubulin (TUBB6) as predictive biomarkers.", "Using immunohistochemistry and nanofluidics, the expression of TUBB3 and TUBB6 was a...
The involvement of androgens in the TUBB3 pathway opens the way for clinical trials to assess the efficacy of antiandrogens for increasing the efficacy of chemotherapy in male colorectal cancer patients.
yes
pub_med_qa40005
[ { "content": "์„ฑ๋ณ„์ด ๋Œ€์žฅ์•”์—์„œ ๋‚˜์œ ๊ฒฐ๊ณผ๋ฅผ ์˜ˆ์ธกํ•˜๋Š” III๊ธ‰ ๋ฐ V๊ธ‰ ๋ฒ ํƒ€-ํŠœ๋ถˆ๋ฆฐ ๋Šฅ๋ ฅ์— ์˜ํ–ฅ์„ ๋ฏธ์น˜๋Š”๊ฐ€?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๋Œ€์žฅ์•”์€ ์„œ๊ตฌ ๊ตญ๊ฐ€์—์„œ ๊ฐ€์žฅ ์น˜๋ช…์ ์ธ ์งˆ๋ณ‘ ์ค‘ ํ•˜๋‚˜์ž…๋‹ˆ๋‹ค. ์น˜๋ฃŒ ๊ฒฐ๊ณผ๋ฅผ ์˜ˆ์ธกํ•˜๊ธฐ ์œ„ํ•ด ํด๋ž˜์Šค III(TUBB3)์™€ ํด๋ž˜์Šค V ๋ฒ ํƒ€-ํŠœ๋ถˆ๋ฆฐ(TUBB6)์˜ ์˜ˆ์ธก ๋ฐ”์ด์˜ค๋งˆ์ปค๋กœ์„œ์˜ ์—ญํ• ์„ ํ‰๊ฐ€ํ–ˆ์Šต๋‹ˆ๋‹ค.\n\n2)\n๋ฉด์—ญ์กฐ์งํ™”ํ•™๊ณผ ๋‚˜๋…ธ์œ ์ฒดํ•™์„ ์‚ฌ์šฉํ•˜์—ฌ ๊ฐ๊ฐ 180๋ช…๊ณผ 134๋ช…์˜ ํ™˜์ž๋กœ ๊ตฌ์„ฑ๋œ ๋‘ ์ง‘๋‹จ์—์„œ TUBB3์™€ TUBB6์˜ ๋ฐœํ˜„์„ ํ‰๊ฐ€ํ–ˆ์Šต๋‹ˆ๋‹ค...
The involvement of androgens in the TUBB3 pathway opens the way for clinical trials to assess the efficacy of antiandrogens for increasing the efficacy of chemotherapy in male colorectal cancer patients.
TUBB3 ๊ฒฝ๋กœ์— ์•ˆ๋“œ๋กœ๊ฒ์ด ๊ด€์—ฌํ•จ์œผ๋กœ์จ ๋‚จ์„ฑ ๋Œ€์žฅ์•” ํ™˜์ž์—์„œ ํ•ญ์•”์ œ์˜ ํšจ๋Šฅ์„ ๋†’์ด๊ธฐ ์œ„ํ•œ ํ•ญ์•ˆ๋“œ๋กœ๊ฒ์˜ ํšจ๋Šฅ์„ ํ‰๊ฐ€ํ•  ์ˆ˜ ์žˆ๋Š” ์ž„์ƒ ์‹œํ—˜์˜ ๊ธธ์ด ์—ด๋ ธ์Šต๋‹ˆ๋‹ค.
22,441,253
Does highly active antiretroviral therapy completely suppress HIV in semen of sexually active HIV-infected men who have sex with men?
{ "contexts": [ "Although HAART can suppress genital shedding and sexual transmission of HIV, men who have sex with men (MSM) have experienced a resurgent HIV epidemic in the HAART era. Many HIV-infected MSM continue to engage in unsafe sex, and sexually transmitted infections (STIs) or other factors may promote ...
STIs and genital inflammation can partially override the suppressive effect of HAART on seminal HIV shedding in sexually active HIV-infected MSM. Low seminal HIV titers could potentially pose a transmission risk in MSM, who are highly susceptible to HIV infection.
no
pub_med_qa40006
[ { "content": "๊ณ ํ™œ์„ฑ ํ•ญ๋ ˆํŠธ๋กœ๋ฐ”์ด๋Ÿฌ์Šค ์š”๋ฒ•์ด ๋‚จ์„ฑ๊ณผ ์„ฑ๊ด€๊ณ„๋ฅผ ๊ฐ€์ง„ ์„ฑ์ ์œผ๋กœ ํ™œ๋™์ ์ธ HIV ๊ฐ์—ผ ๋‚จ์„ฑ์˜ ์ •์•ก์—์„œ HIV๋ฅผ ์™„์ „ํžˆ ์–ต์ œํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\nHAART๋Š” HIV์˜ ์ƒ์‹๊ธฐ ๋ฐฐ์ถœ๊ณผ ์„ฑ์  ์ „ํŒŒ๋ฅผ ์–ต์ œํ•  ์ˆ˜ ์žˆ์ง€๋งŒ, ๋‚จ์„ฑ(MSM)๊ณผ ์„ฑ๊ด€๊ณ„๋ฅผ ๊ฐ€์ง„ ๋‚จ์„ฑ๋“ค์€ HAART ์‹œ๋Œ€์— ๋‹ค์‹œ HIV ์œ ํ–‰์„ ๊ฒฝํ—˜ํ–ˆ์Šต๋‹ˆ๋‹ค. ๋งŽ์€ HIV ๊ฐ์—ผ MSM์ด ์—ฌ์ „ํžˆ ์•ˆ์ „ํ•˜์ง€ ์•Š์€ ์„ฑ๊ด€๊ณ„๋ฅผ ํ•˜๊ณ  ์žˆ์œผ๋ฉฐ, ์„ฑ๋ณ‘ ๊ฐ์—ผ(STI)์ด๋‚˜ ๊ธฐํƒ€ ์š”์ธ๋“ค์ด HAART์—๋„ ๋ถˆ๊ตฌํ•˜๊ณ  ์ด ์ง‘๋‹จ์—์„œ ์ƒ์‹...
STIs and genital inflammation can partially override the suppressive effect of HAART on seminal HIV shedding in sexually active HIV-infected MSM. Low seminal HIV titers could potentially pose a transmission risk in MSM, who are highly susceptible to HIV infection.
STI์™€ ์ƒ์‹๊ธฐ ์—ผ์ฆ์€ ์„ฑํ–‰๋™์„ฑ HIV์— ๊ฐ์—ผ๋œ MSM์—์„œ ์ •์•ก HIV ๋ฐฐ์ถœ์— ๋Œ€ํ•œ HAART์˜ ์–ต์ œ ํšจ๊ณผ๋ฅผ ๋ถ€๋ถ„์ ์œผ๋กœ ๋ฌด์‹œํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ •์•ก HIV ์—ญ๊ฐ€๊ฐ€ ๋‚ฎ์œผ๋ฉด HIV ๊ฐ์—ผ์— ๋งค์šฐ ์ทจ์•ฝํ•œ MSM์—์„œ ์ „์—ผ ์œ„ํ—˜์ด ๋ฐœ์ƒํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
22,436,412
Do circulating interleukin-6 levels correlate with residual HIV viraemia and markers of immune dysfunction in treatment-controlled HIV-infected patients?
{ "contexts": [ "Antiretroviral therapy (ART)-controlled HIV-infected patients have elevated levels of systemic inflammatory markers, C-reactive protein (CRP) and interleukin (IL)-6, which correlate with increased cardiovascular risk and/or mortality. Persistent low-level viral replication could be involved in th...
We report here that low-range IL-6 levels correlated with low-range VL and inversely with sCD14 and IL-8. Our findings suggest that maintaining VL<30 copies/ml in HIV-infected patients might therefore reduce IL-6.
yes
pub_med_qa40007
[ { "content": "์ˆœํ™˜ํ•˜๋Š” ์ธํ„ฐ๋ฃจํ‚จ-6 ์ˆ˜์น˜๊ฐ€ ์น˜๋ฃŒ ๋Œ€์กฐ HIV ๊ฐ์—ผ ํ™˜์ž์˜ ์ž”์—ฌ HIV ๋ฐ”์ด๋Ÿฌ์Šค ํ˜ˆ์ฆ ๋ฐ ๋ฉด์—ญ ๊ธฐ๋Šฅ ์žฅ์• ์˜ ์ง€ํ‘œ์™€ ์ƒ๊ด€๊ด€๊ณ„๊ฐ€ ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ˆœํ™˜ํ•˜๋Š” ์ธํ„ฐ๋ฃจํ‚จ-6 ์ˆ˜์น˜๊ฐ€ ์น˜๋ฃŒ ๋Œ€์กฐ HIV ๊ฐ์—ผ ํ™˜์ž์˜ ์ž”์—ฌ HIV ๋ฐ”์ด๋Ÿฌ์Šค ํ˜ˆ์ฆ ๋ฐ ๋ฉด์—ญ ๊ธฐ๋Šฅ ์žฅ์• ์˜ ์ง€ํ‘œ์™€ ์ƒ๊ด€๊ด€๊ณ„๊ฐ€ ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "passage" } ]
We report here that low-range IL-6 levels correlated with low-range VL and inversely with sCD14 and IL-8. Our findings suggest that maintaining VL<30 copies/ml in HIV-infected patients might therefore reduce IL-6.
์šฐ๋ฆฌ๋Š” ์—ฌ๊ธฐ์—์„œ ๋‚ฎ์€ ๋ฒ”์œ„์˜ IL-6 ์ˆ˜์น˜๊ฐ€ ๋‚ฎ์€ ๋ฒ”์œ„์˜ VL๊ณผ ์ƒ๊ด€๊ด€๊ณ„๊ฐ€ ์žˆ์œผ๋ฉฐ, ๋ฐ˜๋Œ€๋กœ sCD14 ๋ฐ IL-8๊ณผ ์ƒ๊ด€๊ด€๊ณ„๊ฐ€ ์žˆ์Œ์„ ๋ณด๊ณ ํ•ฉ๋‹ˆ๋‹ค. ์šฐ๋ฆฌ์˜ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” HIV์— ๊ฐ์—ผ๋œ ํ™˜์ž์—์„œ VL<30 ์นดํ”ผ/ml๋ฅผ ์œ ์ง€ํ•˜๋ฉด IL-6๋ฅผ ์ค„์ผ ์ˆ˜ ์žˆ์Œ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
22,423,977
Does network motif comparison rationalize Sec1/Munc18-SNARE regulation mechanism in exocytosis?
{ "contexts": [ "Network motifs, recurring subnetwork patterns, provide significant insight into the biological networks which are believed to govern cellular processes.", "We present a comparative network motif experimental approach, which helps to explain complex biological phenomena and increases the under...
Therefore this study provides a new method to solve the discrepancies and to generalize the functional role of SM proteins.
yes
pub_med_qa40008
[ { "content": "๋„คํŠธ์›Œํฌ ๋ชจํ‹ฐํ”„ ๋น„๊ต๊ฐ€ ์—‘์†Œ์‚ฌ์ดํ† ์‹œ์Šค์—์„œ Sec1/Munc18-SNARE ์กฐ์ ˆ ๋ฉ”์ปค๋‹ˆ์ฆ˜์„ ํ•ฉ๋ฆฌํ™”ํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๋„คํŠธ์›Œํฌ ๋ชจํ‹ฐํ”„, ๋ฐ˜๋ณต์ ์ธ ํ•˜์œ„ ๋„คํŠธ์›Œํฌ ํŒจํ„ด์€ ์„ธํฌ ๊ณผ์ •์„ ์ง€๋ฐฐํ•˜๋Š” ๊ฒƒ์œผ๋กœ ์—ฌ๊ฒจ์ง€๋Š” ์ƒ๋ฌผํ•™์  ๋„คํŠธ์›Œํฌ์— ๋Œ€ํ•œ ์ค‘์š”ํ•œ ํ†ต์ฐฐ๋ ฅ์„ ์ œ๊ณตํ•ฉ๋‹ˆ๋‹ค.\n\n2)\n๋ณต์žกํ•œ ์ƒ๋ฌผํ•™์  ํ˜„์ƒ์„ ์„ค๋ช…ํ•˜๊ณ  ๋„คํŠธ์›Œํฌ ๋ชจํ‹ฐํ”„์˜ ์ง„ํ™” ์„ค๊ณ„ ์›๋ฆฌ๋ฅผ ํƒ๊ตฌํ•˜์—ฌ ๋ถ„์ž ์ˆ˜์ค€์—์„œ ์ƒ๋ฌผํ•™์  ๊ธฐ๋Šฅ์— ๋Œ€ํ•œ ์ดํ•ด๋ฅผ ๋†’์ด๋Š” ๋น„๊ต ๋„คํŠธ์›Œํฌ ๋ชจํ‹ฐํ”„ ์‹คํ—˜ ์ ‘๊ทผ๋ฒ•์„ ์ œ์‹œํ•ฉ๋‹ˆ๋‹ค.\n\...
Therefore this study provides a new method to solve the discrepancies and to generalize the functional role of SM proteins.
๋”ฐ๋ผ์„œ ์ด ์—ฐ๊ตฌ๋Š” ๋ถˆ์ผ์น˜๋ฅผ ํ•ด๊ฒฐํ•˜๊ณ  SM ๋‹จ๋ฐฑ์งˆ์˜ ๊ธฐ๋Šฅ์  ์—ญํ• ์„ ์ผ๋ฐ˜ํ™”ํ•  ์ˆ˜ ์žˆ๋Š” ์ƒˆ๋กœ์šด ๋ฐฉ๋ฒ•์„ ์ œ๊ณตํ•ฉ๋‹ˆ๋‹ค.
22,430,890
Does bilobar spreading of colorectal liver metastases significantly affect survival after R0 resection in the era of interdisciplinary multimodal treatment?
{ "contexts": [ "Bilobar colorectal liver metastases (CRLM) are often considered incurable or associated with poor prognosis even after R0 resection. In this single-center study, we evaluate the impact of CRLM spreading on recurrence-free survival (RFS) and cancer-specific overall survival (CSS) after R0 resectio...
To our single-center experience, there is no significant effect of CRLM spreading (bilobar versus unilobar) on RFS and CSS rates. Bilobar CRLM are more likely to require extended multimodal efforts to achieve R0 resection.
no
pub_med_qa40009
[ { "content": "๋‹คํ•™์ œ ๊ฐ„ ์น˜๋ฃŒ ์‹œ๋Œ€์— ๋Œ€์žฅ ๊ฐ„ ์ „์ด์˜ ์ด์ค‘ ๋ง‰๋Œ€ ํ™•์‚ฐ์ด R0 ์ ˆ์ œ์ˆ  ํ›„ ์ƒ์กด์— ํฐ ์˜ํ–ฅ์„ ๋ฏธ์น˜๋‚˜์š”?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์ด์ค‘ ๋ฐ” ๋Œ€์žฅ๊ฐ„ ์ „์ด(CRLM)๋Š” ์ข…์ข… ๋ถˆ์น˜๋ณ‘์œผ๋กœ ๊ฐ„์ฃผ๋˜๊ฑฐ๋‚˜ R0 ์ ˆ์ œ ํ›„์—๋„ ์˜ˆํ›„๊ฐ€ ์ข‹์ง€ ์•Š์€ ๊ฒƒ์œผ๋กœ ๊ฐ„์ฃผ๋ฉ๋‹ˆ๋‹ค. ์ด ๋‹จ์ผ ์„ผํ„ฐ ์—ฐ๊ตฌ์—์„œ๋Š” ์ˆ˜์ˆ  ์ „ํ›„ ํ™”ํ•™ ์š”๋ฒ• ๋ฐ ๋‹ค๋‹จ๊ณ„ ์ ˆ์ œ๋ฅผ ํฌํ•จํ•œ ๋‹ค์ค‘ ๋ชจ๋“œ ์น˜๋ฃŒ ์ „๋žต๊ณผ ๊ด€๋ จํ•˜์—ฌ CRLM์˜ R0 ์ ˆ์ œ ํ›„ CRLM ํ™•์‚ฐ์ด ๋ฌด์žฌ๋ฐœ ์ƒ์กด์œจ(RFS) ๋ฐ ์•” ํŠน์ด์  ์ „์ฒด ์ƒ์กด์œจ(CSS)์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ...
To our single-center experience, there is no significant effect of CRLM spreading (bilobar versus unilobar) on RFS and CSS rates. Bilobar CRLM are more likely to require extended multimodal efforts to achieve R0 resection.
๋‹จ์ผ ์„ผํ„ฐ ๊ฒฝํ—˜์— ๋”ฐ๋ฅด๋ฉด, CRLM ํ™•์‚ฐ(๋นŒ๋กœ๋ฐ” ๋Œ€ ์œ ๋‹ˆ๋กœ๋ฐ”)์ด RFS ๋ฐ CSS ๋น„์œจ์— ๋ฏธ์น˜๋Š” ์œ ์˜๋ฏธํ•œ ์˜ํ–ฅ์€ ์—†์Šต๋‹ˆ๋‹ค. ๋นŒ๋กœ๋ฐ” CRLM์€ R0 ์ ˆ์ œ๋ฅผ ๋‹ฌ์„ฑํ•˜๊ธฐ ์œ„ํ•ด ํ™•์žฅ๋œ ๋‹ค์ค‘ ๋ชจ๋‹ฌ ๋…ธ๋ ฅ์ด ๋” ํ•„์š”ํ•  ๊ฐ€๋Šฅ์„ฑ์ด ๋†’์Šต๋‹ˆ๋‹ค.
22,440,531
Does socioeconomic deprivation predict outcome following radial head and neck fractures?
{ "contexts": [ "There is increasing evidence demonstrating an association between fracture epidemiology and socioeconomic status. However, the influence of socioeconomic deprivation on fracture outcome has not been documented before. The aim of this study was to determine if socioeconomic deprivation influenced ...
We have a shown a clear correlation between functional outcome and socioeconomic status, with the most deprived patients reporting a poorer outcome. Future work should be aimed at determining which aspects of deprivation influence patient outcome, with modifiable factors targeted in future health-care planning.
yes
pub_med_qa40010
[ { "content": "๋ฐฉ์‚ฌ์ƒ ๋‘๊ฒฝ๋ถ€ ๊ณจ์ ˆ ํ›„ ์‚ฌํšŒ๊ฒฝ์ œ์  ๋ฐ•ํƒˆ์ด ๊ฒฐ๊ณผ๋ฅผ ์˜ˆ์ธกํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๊ณจ์ ˆ ์—ญํ•™๊ณผ ์‚ฌํšŒ๊ฒฝ์ œ์  ์ง€์œ„ ์‚ฌ์ด์˜ ์—ฐ๊ด€์„ฑ์„ ์ž…์ฆํ•˜๋Š” ์ฆ๊ฑฐ๊ฐ€ ์ ์  ๋” ๋งŽ์•„์ง€๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ์‚ฌํšŒ๊ฒฝ์ œ์  ๋ฐ•ํƒˆ์ด ๊ณจ์ ˆ ๊ฒฐ๊ณผ์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์€ ์ด์ „์— ๋ฌธ์„œํ™”๋œ ๋ฐ”๊ฐ€ ์—†์Šต๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ์˜ ๋ชฉ์ ์€ ์š”๊ณจ๋‘๋‚˜ ๋ชฉ ๊ณจ์ ˆ ํ›„ ์‚ฌํšŒ๊ฒฝ์ œ์  ๋ฐ•ํƒˆ์ด ๋‹จ๊ธฐ ๊ฒฐ๊ณผ์— ์˜ํ–ฅ์„ ๋ฏธ์น˜๋Š”์ง€ ํ™•์ธํ•˜๋Š” ๊ฒƒ์ด์—ˆ์Šต๋‹ˆ๋‹ค.\n\n2)\n์ „ํ–ฅ์  ๋ฐ์ดํ„ฐ๋ฒ ์ด์Šค๋ฅผ ํ†ตํ•ด 18๊ฐœ์›” ๋™์•ˆ ์š”๊ณจ๋‘ ๋˜๋Š” ๋ชฉ ๊ณจ์ ˆ์„ ์ž…์€ ๋ชจ๋“  ํ™˜์ž...
We have a shown a clear correlation between functional outcome and socioeconomic status, with the most deprived patients reporting a poorer outcome. Future work should be aimed at determining which aspects of deprivation influence patient outcome, with modifiable factors targeted in future health-care planning.
๊ธฐ๋Šฅ์  ๊ฒฐ๊ณผ์™€ ์‚ฌํšŒ๊ฒฝ์ œ์  ์ƒํƒœ ์‚ฌ์ด์— ๋ช…ํ™•ํ•œ ์ƒ๊ด€๊ด€๊ณ„๊ฐ€ ์žˆ์Œ์„ ๋ณด์—ฌ์ฃผ์—ˆ์œผ๋ฉฐ, ๊ฐ€์žฅ ๋ฐ•ํƒˆ๊ฐ์ด ์‹ฌํ•œ ํ™˜์ž๋“ค์€ ๋” ๋‚˜์œ ๊ฒฐ๊ณผ๋ฅผ ๋ณด๊ณ ํ–ˆ์Šต๋‹ˆ๋‹ค. ํ–ฅํ›„ ์—ฐ๊ตฌ๋Š” ๋ฐ•ํƒˆ๊ฐ์˜ ์–ด๋–ค ์ธก๋ฉด์ด ํ™˜์ž ๊ฒฐ๊ณผ์— ์˜ํ–ฅ์„ ๋ฏธ์น˜๋Š”์ง€ ํŒŒ์•…ํ•˜๋Š” ๊ฒƒ์„ ๋ชฉํ‘œ๋กœ ํ•˜๋ฉฐ, ํ–ฅํ›„ ์˜๋ฃŒ ๊ณ„ํš์—์„œ ์ˆ˜์ • ๊ฐ€๋Šฅํ•œ ์š”์ธ๋“ค์„ ๋ชฉํ‘œ๋กœ ํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค.
22,429,000
Do gene expression profiles of phaeochromocytomas with ERBB2 overexpression reveal a new molecular mechanism tumourigenicity?
{ "contexts": [ "Phaeochromocytomas (PHEO) and functional paragangliomas (PGLs) are catecholamine-secreting neuroendocrine tumours. Although most PHEO/PGLs are benign, 10-35% present as (or develop into) malignant tumours with a poor prognosis. Overexpression of ERBB2 (v-erb-b2 erythroblastic leukaemia viral onco...
In summary, ERBB2+ PHEO/PGLs have a distinct expression pattern compared with the ERBB2- group. The focal adhesion signalling pathway may participate in ERBB2-induced tumourigenesis in PHEO/PGLs.
yes
pub_med_qa40011
[ { "content": "ERBB2 ๊ณผ๋ฐœํ˜„์ด ์žˆ๋Š” ํ˜ˆ์ƒ‰์†Œ์„ธํฌ์ข…์˜ ์œ ์ „์ž ๋ฐœํ˜„ ํ”„๋กœํ•„์—์„œ ์ƒˆ๋กœ์šด ๋ถ„์ž ๊ธฐ์ „ ์ข…์–‘ ๋ฐœ์ƒ์„ฑ์ด ๋ฐํ˜€์กŒ์Šต๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\nํŽ˜์˜คํฌ๋กœ๋ชจ์‹œํ† ๋งˆ(PHEO)์™€ ๊ธฐ๋Šฅ์„ฑ ๋ถ€๊ต์„ธํฌ์ข…(PGL)์€ ์นดํ…Œ์ฝœ์•„๋ฏผ์„ ๋ถ„๋น„ํ•˜๋Š” ์‹ ๊ฒฝ๋‚ด๋ถ„๋น„ ์ข…์–‘์ž…๋‹ˆ๋‹ค. ๋Œ€๋ถ€๋ถ„์˜ PHEO/PGL์€ ์–‘์„ฑ์ด์ง€๋งŒ, 10-35%๋Š” ์˜ˆํ›„๊ฐ€ ์ข‹์ง€ ์•Š์€ ์•…์„ฑ ์ข…์–‘์œผ๋กœ ์กด์žฌํ•˜๊ฑฐ๋‚˜ ๋ฐœ์ƒํ•ฉ๋‹ˆ๋‹ค. ERBB2(v-erb-b ์ ํ˜ˆ๊ตฌ ๋ฐฑํ˜ˆ๋ณ‘ ๋ฐ”์ด๋Ÿฌ์Šค ์ข…์–‘ ์œ ์ „์ž ์ƒ๋™์ฒด 2)์˜ ๊ณผ๋ฐœํ˜„์€ ์•…์„ฑ PHEO์™€ ๊ด€๋ จ์ด ์žˆ๋Š” ๊ฒƒ...
In summary, ERBB2+ PHEO/PGLs have a distinct expression pattern compared with the ERBB2- group. The focal adhesion signalling pathway may participate in ERBB2-induced tumourigenesis in PHEO/PGLs.
์š”์•ฝํ•˜๋ฉด, ERBB2+ PHEO/PGL์€ ERBB2- ๊ทธ๋ฃน์— ๋น„ํ•ด ๋šœ๋ ทํ•œ ๋ฐœํ˜„ ํŒจํ„ด์„ ๋ณด์ž…๋‹ˆ๋‹ค. ๊ตญ์†Œ ์ ‘์ฐฉ ์‹ ํ˜ธ ๊ฒฝ๋กœ๋Š” PHEO/PGL์—์„œ ERBB2์— ์˜ํ•ด ์œ ๋„๋œ ์ข…์–‘ ๋ฐœ์ƒ์— ์ฐธ์—ฌํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
22,425,051
Is prospective tracking of pediatric urology consults : knowing half the battle?
{ "contexts": [ "The planned clinical activity of pediatric urologists has been well described. However, little is known about nonscheduled work (eg consultation requests). We describe the unplanned clinical activity of pediatric urologists at a high volume academic medical center.", "Demographic data regardi...
At our academic pediatric hospital we averaged nearly 1 unplanned pediatric urology consult per day. Several service specific factors (unrelated to patient diagnosis or acuity) were associated with whether the consult had the potential to generate revenue. Unplanned clinical activity is an important factor to consider ...
yes
pub_med_qa40012
[ { "content": "์†Œ์•„ ๋น„๋‡จ๊ธฐ๊ณผ ์ƒ๋‹ด์˜ ์ „ํ–ฅ์  ์ถ”์ : ์ ˆ๋ฐ˜์„ ์•„๋Š” ๊ฒƒ์ด ์‹ธ์›€์˜ ์ ˆ๋ฐ˜์ธ๊ฐ€์š”?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์†Œ์•„ ๋น„๋‡จ๊ธฐ๊ณผ ์ „๋ฌธ์˜์˜ ๊ณ„ํš๋œ ์ž„์ƒ ํ™œ๋™์€ ์ž˜ ์„ค๋ช…๋˜์–ด ์žˆ์Šต๋‹ˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ์˜ˆ์•ฝ๋˜์ง€ ์•Š์€ ์—…๋ฌด(์˜ˆ: ์ƒ๋‹ด ์š”์ฒญ)์— ๋Œ€ํ•ด์„œ๋Š” ์•Œ๋ ค์ง„ ๋ฐ”๊ฐ€ ๊ฑฐ์˜ ์—†์Šต๋‹ˆ๋‹ค. ์šฐ๋ฆฌ๋Š” ๋Œ€๊ทœ๋ชจ ํ•™์ˆ  ์˜๋ฃŒ ์„ผํ„ฐ์—์„œ ์†Œ์•„ ๋น„๋‡จ๊ธฐ๊ณผ ์ „๋ฌธ์˜์˜ ๊ณ„ํš๋˜์ง€ ์•Š์€ ์ž„์ƒ ํ™œ๋™์— ๋Œ€ํ•ด ์„ค๋ช…ํ•ฉ๋‹ˆ๋‹ค.\n\n2)\n์ž…์› ํ™˜์ž, ์ˆ˜์ˆ ์‹ค ๋ฐ ์‘๊ธ‰์‹ค ์†Œ์•„ ๋น„๋‡จ๊ธฐ๊ณผ ์ƒ๋‹ด์— ๊ด€ํ•œ ์ธ๊ตฌํ†ต๊ณ„ํ•™์  ๋ฐ์ดํ„ฐ๋Š” ์ „ํ–ฅ์ ์œผ๋กœ ๋‚ด๋ถ€ ๋ฐ...
At our academic pediatric hospital we averaged nearly 1 unplanned pediatric urology consult per day. Several service specific factors (unrelated to patient diagnosis or acuity) were associated with whether the consult had the potential to generate revenue. Unplanned clinical activity is an important factor to consider ...
์ €ํฌ ํ•™์ˆ  ์†Œ์•„๋ณ‘์›์—์„œ๋Š” ํ•˜๋ฃจ ํ‰๊ท  ๊ฑฐ์˜ 1๊ฑด์˜ ๊ณ„ํš๋˜์ง€ ์•Š์€ ์†Œ์•„ ๋น„๋‡จ๊ธฐ๊ณผ ์ƒ๋‹ด์„ ์ง„ํ–‰ํ–ˆ์Šต๋‹ˆ๋‹ค. ํ™˜์ž ์ง„๋‹จ์ด๋‚˜ ์‹œ๋ ฅ๊ณผ ๋ฌด๊ด€ํ•œ ์—ฌ๋Ÿฌ ์„œ๋น„์Šค๋ณ„ ์š”์ธ(ํ™˜์ž ์ง„๋‹จ์ด๋‚˜ ์‹œ๋ ฅ๊ณผ๋Š” ๋ฌด๊ด€)์ด ์ƒ๋‹ด์ด ์ˆ˜์ต ์ฐฝ์ถœ์˜ ์ž ์žฌ๋ ฅ์„ ๊ฐ€์ง€๊ณ  ์žˆ๋Š”์ง€ ์—ฌ๋ถ€์™€ ๊ด€๋ จ์ด ์žˆ์—ˆ์Šต๋‹ˆ๋‹ค. ๊ณ„ํš๋˜์ง€ ์•Š์€ ์ž„์ƒ ํ™œ๋™์€ ๋ถ€์„œ๋ณ„ ์ž๊ธˆ ์ง€์›, ์ธ๋ ฅ ๋ฐฐ์น˜ ๋ฐ ๊ต์œก์„ ๊ณ„ํšํ•  ๋•Œ ๊ณ ๋ คํ•ด์•ผ ํ•  ์ค‘์š”ํ•œ ์š”์†Œ์ž…๋‹ˆ๋‹ค.
22,440,482
Is depression improvement related to social role functioning after stroke?
{ "contexts": [ "To (1) examine the relationships between baseline demographic, clinical, and psychological characteristics and social role functioning (SRF) at 4 months after stroke, and (2) assess whether depression improvement is associated with 4-month SRF.", "We completed a secondary data analysis using ...
Among stroke survivors with depression, improvement of that depression was independently associated with improved SRF. This is a reminder of the importance for rehabilitation providers to screen for and treat poststroke depression.
yes
pub_med_qa40013
[ { "content": "๋‡Œ์กธ์ค‘ ํ›„ ์šฐ์šธ์ฆ ๊ฐœ์„ ์ด ์‚ฌํšŒ์  ์—ญํ• ๊ณผ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n(1) ๋‡Œ์กธ์ค‘ ํ›„ 4๊ฐœ์›” ์‹œ์ ์—์„œ ๊ธฐ์ดˆ ์ธ๊ตฌํ†ต๊ณ„ํ•™์ , ์ž„์ƒ์ , ์‹ฌ๋ฆฌ์  ํŠน์„ฑ๊ณผ ์‚ฌํšŒ์  ์—ญํ•  ๊ธฐ๋Šฅ(SRF) ๊ฐ„์˜ ๊ด€๊ณ„๋ฅผ ์กฐ์‚ฌํ•˜๊ณ , (2) ์šฐ์šธ์ฆ ๊ฐœ์„ ์ด 4๊ฐœ์›” ์‹œ์ ์˜ SRF์™€ ๊ด€๋ จ์ด ์žˆ๋Š”์ง€ ํ‰๊ฐ€ํ•ฉ๋‹ˆ๋‹ค.\n\n2)\n์šฐ์šธ์ฆ ์œ ๋ฌด์— ๊ด€๊ณ„์—†์ด ๋‡Œ์กธ์ค‘ ํ™˜์ž๋ฅผ ํฌํ•จํ•œ ์ฝ”ํ˜ธํŠธ ์—ฐ๊ตฌ๋ฅผ ์™„๋ฃŒํ•˜์—ฌ 2์ฐจ ๋ฐ์ดํ„ฐ ๋ถ„์„์„ ์™„๋ฃŒํ–ˆ์Šต๋‹ˆ๋‹ค. ๋‹ค์ค‘ ์„ ํ˜• ํšŒ๊ท€ ๋ถ„์„์„ ์‚ฌ์šฉํ•˜์—ฌ 12์ฃผ SRF์™€ ๋…๋ฆฝ์ ์œผ๋กœ ์—ฐ๊ด€๋œ...
Among stroke survivors with depression, improvement of that depression was independently associated with improved SRF. This is a reminder of the importance for rehabilitation providers to screen for and treat poststroke depression.
์šฐ์šธ์ฆ์„ ์•“๊ณ  ์žˆ๋Š” ๋‡Œ์กธ์ค‘ ์ƒ์กด์ž ์ค‘ ์šฐ์šธ์ฆ์˜ ๊ฐœ์„ ์€ ๋…๋ฆฝ์ ์œผ๋กœ SRF ๊ฐœ์„ ๊ณผ ๊ด€๋ จ์ด ์žˆ์—ˆ์Šต๋‹ˆ๋‹ค. ์ด๋Š” ์žฌํ™œ ์ œ๊ณต์ž๊ฐ€ ๋‡Œ์กธ์ค‘ ํ›„ ์šฐ์šธ์ฆ์„ ์„ ๋ณ„ํ•˜๊ณ  ์น˜๋ฃŒํ•˜๋Š” ๊ฒƒ์ด ์–ผ๋งˆ๋‚˜ ์ค‘์š”ํ•œ์ง€๋ฅผ ์ƒ๊ธฐ์‹œ์ผœ ์ค๋‹ˆ๋‹ค.
22,429,613
Does microRNA profiling of hepatocarcinogenesis identify C19MC cluster as a novel prognostic biomarker in hepatocellular carcinoma?
{ "contexts": [ "Progressive hepatocarcinogenesis is a stepwise process that drives liver transformation. However, the molecular mechanisms of early liver transformation are far from clear. A role for microRNAs (miRNA) as diagnostic and prognostic factors in human tumours, including hepatocellular carcinoma (HCC)...
C19MC cluster is a novel molecular alteration characteristic of liver cancer and predictor of poor prognosis. C19MC is an attractive candidate for novel HCC therapies.
yes
pub_med_qa40014
[ { "content": "๊ฐ„์•” ๋ฐœ์ƒ์˜ ๋งˆ์ดํฌ๋กœRNA ํ”„๋กœํŒŒ์ผ๋ง์ด ๊ฐ„์„ธํฌ์•”์—์„œ C19MC ๊ตฐ์ง‘์„ ์ƒˆ๋กœ์šด ์˜ˆํ›„ ๋ฐ”์ด์˜ค๋งˆ์ปค๋กœ ์‹๋ณ„ํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์ง„ํ–‰์„ฑ ๊ฐ„์•” ๋ฐœ์ƒ์€ ๊ฐ„ ๋ณ€ํ˜•์„ ์œ ๋„ํ•˜๋Š” ๋‹จ๊ณ„์  ๊ณผ์ •์ž…๋‹ˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ์ดˆ๊ธฐ ๊ฐ„ ๋ณ€ํ˜•์˜ ๋ถ„์ž์  ๋ฉ”์ปค๋‹ˆ์ฆ˜์€ ์•„์ง ๋ช…ํ™•ํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ๊ฐ„์„ธํฌ์•”(HCC)์„ ํฌํ•จํ•œ ์ธ๊ฐ„ ์ข…์–‘์˜ ์ง„๋‹จ ๋ฐ ์˜ˆํ›„ ์ธ์ž๋กœ์„œ ๋งˆ์ดํฌ๋กœRNA(miRNA)์˜ ์—ญํ• ์€ ์œ ๋งํ•ฉ๋‹ˆ๋‹ค. ์šฐ๋ฆฌ๋Š” ์ƒˆ๋กœ์šด miRNA๋ฅผ ์งˆ๋ณ‘ ์ง„ํ–‰์˜ ๊ฐ๋ณ„ ์ง„๋‹จ ๋ฐ ์˜ˆ์ธก์„ ์œ„ํ•œ ๋ฐ”์ด์˜ค๋งˆ์ปค๋กœ ์‹๋ณ„ํ•˜๋Š” ๊ฒƒ์„...
C19MC cluster is a novel molecular alteration characteristic of liver cancer and predictor of poor prognosis. C19MC is an attractive candidate for novel HCC therapies.
C19MC ํด๋Ÿฌ์Šคํ„ฐ๋Š” ๊ฐ„์•”์˜ ์ƒˆ๋กœ์šด ๋ถ„์ž ๋ณ€ํ™” ํŠน์„ฑ์ด๋ฉฐ ์˜ˆํ›„๊ฐ€ ์ข‹์ง€ ์•Š์€ ์˜ˆ์ธก ์ธ์ž์ž…๋‹ˆ๋‹ค. C19MC๋Š” ์ƒˆ๋กœ์šด ๊ฐ„์„ธํฌ์•” ์น˜๋ฃŒ๋ฒ•์˜ ๋งค๋ ฅ์ ์ธ ํ›„๋ณด์ž…๋‹ˆ๋‹ค.
22,445,519
Are bodybuilding , energy , and weight-loss supplements associated with deployment and physical activity in U.S. military personnel?
{ "contexts": [ "The characteristics of U.S. military personnel who use dietary supplements have not been well described. This study aimed to determine whether deployment experience and physical activity were associated with the use of bodybuilding, energy, or weight-loss supplement among U.S. military personnel....
The high prevalence of supplement use and important characteristics found to be associated with their use, including deployment, physical activity, and suboptimal sleep, suggest focus areas for future research and adverse event monitoring.
yes
pub_med_qa40015
[ { "content": "๋ณด๋””๋นŒ๋”ฉ, ์—๋„ˆ์ง€, ์ฒด์ค‘ ๊ฐ๋Ÿ‰ ๋ณด์ถฉ์ œ๊ฐ€ ๋ฏธ๊ตฐ ๋ณ‘๋ ฅ์˜ ๋ฐฐ์น˜ ๋ฐ ์‹ ์ฒด ํ™œ๋™๊ณผ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์‹์ด ๋ณด์ถฉ์ œ๋ฅผ ์‚ฌ์šฉํ•˜๋Š” ๋ฏธ๊ตฐ ๋ณ‘๋ ฅ์˜ ํŠน์„ฑ์€ ์ž˜ ์„ค๋ช…๋˜์ง€ ์•Š์•˜์Šต๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ๋Š” ๋ฏธ๊ตฐ ๋ณ‘๋ ฅ์˜ ๋ฐฐ์น˜ ๊ฒฝํ—˜๊ณผ ์‹ ์ฒด ํ™œ๋™์ด ๋ณด๋””๋นŒ๋”ฉ, ์—๋„ˆ์ง€ ๋˜๋Š” ์ฒด์ค‘ ๊ฐ๋Ÿ‰ ๋ณด์ถฉ์ œ ์‚ฌ์šฉ๊ณผ ๊ด€๋ จ์ด ์žˆ๋Š”์ง€ ํ™•์ธํ•˜๋Š” ๊ฒƒ์„ ๋ชฉํ‘œ๋กœ ํ–ˆ์Šต๋‹ˆ๋‹ค.\n\n2)\n2007๋…„๋ถ€ํ„ฐ 2008๋…„๊นŒ์ง€ ์ˆ˜์ง‘๋œ ๋ฐ€๋ ˆ๋‹ˆ์—„ ์ฝ”ํ˜ธํŠธ ์—ฐ๊ตฌ(n = 106,698)์˜ ํ˜„์—ญ, ์˜ˆ๋น„๊ตฐ, ์ฃผ๋ฐฉ์œ„๊ตฐ ์ฐธ๊ฐ€์ž๋“ค์˜ ์ž...
The high prevalence of supplement use and important characteristics found to be associated with their use, including deployment, physical activity, and suboptimal sleep, suggest focus areas for future research and adverse event monitoring.
๋ณด์ถฉ์ œ ์‚ฌ์šฉ์˜ ๋†’์€ ์œ ๋ณ‘๋ฅ ๊ณผ ๋ฐฐ์น˜, ์‹ ์ฒด ํ™œ๋™, ์ˆ˜๋ฉด ๋ถ€์กฑ ๋“ฑ์˜ ์ค‘์š”ํ•œ ํŠน์„ฑ์ด ์‚ฌ์šฉ๊ณผ ๊ด€๋ จ์ด ์žˆ๋‹ค๋Š” ์‚ฌ์‹ค์€ ํ–ฅํ›„ ์—ฐ๊ตฌ์™€ ๋ถ€์ž‘์šฉ ๋ชจ๋‹ˆํ„ฐ๋ง์— ์ค‘์ ์„ ๋‘˜ ํ•„์š”๊ฐ€ ์žˆ์Œ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
22,433,290
Is plasma diamine oxidase activity a useful biomarker for evaluating gastrointestinal tract toxicities during chemotherapy with oral fluorouracil anti-cancer drugs in patients with gastric cancer?
{ "contexts": [ "Diamine oxidase (DAO) is an enzyme that catalyzes oxidation and is highly active in the mature upper villus cells of the intestinal mucosa. This study sought to evaluate plasma DAO activities during adjuvant chemotherapy in patients with gastric cancer.", "We investigated 20 patients with gas...
Plasma DAO activities may be useful for monitoring and evaluating gastrointestinal tract toxicities induced by adjuvant chemotherapy with oral fluorouracil in patients with gastric cancer.
yes
pub_med_qa40016
[ { "content": "ํ˜ˆ์žฅ ๋””์•„๋ฏผ ์‚ฐํ™”ํšจ์†Œ ํ™œ์„ฑ์ด ์œ„์•” ํ™˜์ž์—์„œ ๊ฒฝ๊ตฌ ํ”Œ๋ฃจ์˜ค๋กœ์œ ๋ผ์‹ค ํ•ญ์•”์ œ๋ฅผ ์‚ฌ์šฉํ•œ ํ™”ํ•™ ์š”๋ฒ• ์ค‘ ์œ„์žฅ๊ด€ ๋…์„ฑ์„ ํ‰๊ฐ€ํ•˜๋Š” ๋ฐ ์œ ์šฉํ•œ ๋ฐ”์ด์˜ค๋งˆ์ปค์ž…๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๋””์•„๋ฏผ ์‚ฐํ™”ํšจ์†Œ(DAO)๋Š” ์‚ฐํ™”๋ฅผ ์ด‰๋งคํ•˜๋Š” ํšจ์†Œ๋กœ ์žฅ ์ ๋ง‰์˜ ์„ฑ์ˆ™ํ•œ ์ƒ์•…๊ณจ ์„ธํฌ์—์„œ ๋งค์šฐ ํ™œ๋ฐœํ•˜๊ฒŒ ํ™œ๋™ํ•ฉ๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ๋Š” ์œ„์•” ํ™˜์ž๋ฅผ ๋Œ€์ƒ์œผ๋กœ ๋ณด์กฐ ํ™”ํ•™ ์š”๋ฒ• ์ค‘ ํ˜ˆ์žฅ DAO ํ™œ์„ฑ์„ ํ‰๊ฐ€ํ•˜๊ณ ์ž ํ–ˆ์Šต๋‹ˆ๋‹ค.\n\n2)\n๊ฒฝ๊ตฌ์šฉ ํ”Œ๋ฃจ์˜ค๋กœ์œ ๋ผ์‹ค ํ•ญ์•”์ œ๋ฅผ ๋ณด์กฐ ํ™”ํ•™์š”๋ฒ•์œผ๋กœ ์น˜๋ฃŒ๋ฐ›์€ ์œ„์•” ํ™˜์ž 20๋ช…...
Plasma DAO activities may be useful for monitoring and evaluating gastrointestinal tract toxicities induced by adjuvant chemotherapy with oral fluorouracil in patients with gastric cancer.
ํ˜ˆ์žฅ DAO ํ™œ์„ฑ์€ ์œ„์•” ํ™˜์ž์—์„œ ๊ฒฝ๊ตฌ ํ”Œ๋ฃจ์˜ค๋กœ์œ ๋ผ์‹ค์„ ์‚ฌ์šฉํ•œ ๋ณด์กฐ ํ™”ํ•™ ์š”๋ฒ•์œผ๋กœ ์œ ๋ฐœ๋œ ์œ„์žฅ๊ด€ ๋…์„ฑ์„ ๋ชจ๋‹ˆํ„ฐ๋งํ•˜๊ณ  ํ‰๊ฐ€ํ•˜๋Š” ๋ฐ ์œ ์šฉํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
22,439,862
Are magnetic nanoparticles in primary neural cell cultures mainly taken up by microglia?
{ "contexts": [ "Magnetic nanoparticles (MNPs) offer a large range of applications in life sciences. Applications in neurosciences are one focus of interest. Unfortunately, not all groups have access to nanoparticles or the possibility to develop and produce them for their applications. Hence, they have to focus ...
The commercial MNPs used activated microglial phagocytosis in both disperse and organotypic culture systems. It can be assumed that in vivo application would induce immune system reactivity, too. Because of this, their usefulness for in vivo neuroscientific implementations can be questioned. Future studies will need to...
yes
pub_med_qa40017
[ { "content": "์ผ์ฐจ ์‹ ๊ฒฝ ์„ธํฌ ๋ฐฐ์–‘์—์„œ ์ž์„ฑ ๋‚˜๋…ธ์ž…์ž๋Š” ์ฃผ๋กœ ๋ฏธ์„ธ์•„๊ต์„ธํฌ์— ์˜ํ•ด ํก์ˆ˜๋˜๋‚˜์š”?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์ž๊ธฐ ๋‚˜๋…ธ ์ž…์ž(MNP)๋Š” ์ƒ๋ช… ๊ณผํ•™ ๋ถ„์•ผ์—์„œ ๋‹ค์–‘ํ•œ ์‘์šฉ ๋ถ„์•ผ๋ฅผ ์ œ๊ณตํ•ฉ๋‹ˆ๋‹ค. ์‹ ๊ฒฝ๊ณผํ•™ ๋ถ„์•ผ์—์„œ์˜ ์‘์šฉ์€ ํ•˜๋‚˜์˜ ๊ด€์‹ฌ์‚ฌ์ž…๋‹ˆ๋‹ค. ์•ˆํƒ€๊น๊ฒŒ๋„ ๋ชจ๋“  ๊ทธ๋ฃน์ด ๋‚˜๋…ธ ์ž…์ž์— ์ ‘๊ทผํ•˜๊ฑฐ๋‚˜ ๋‚˜๋…ธ ์ž…์ž๋ฅผ ๊ฐœ๋ฐœํ•˜๊ณ  ์ƒ์‚ฐํ•  ์ˆ˜ ์žˆ๋Š” ๊ฐ€๋Šฅ์„ฑ์„ ๊ฐ€์ง€๊ณ  ์žˆ๋Š” ๊ฒƒ์€ ์•„๋‹™๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ ์ด๋“ค์€ ์ƒ์—…์ ์œผ๋กœ ์ด์šฉ ๊ฐ€๋Šฅํ•œ ์ž…์ž์— ์ง‘์ค‘ํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค. 1์ฐจ ์„ธํฌ์—์„œ ๋‚˜๋…ธ ์ž…์ž์˜ ํก์ˆ˜์— ๋Œ€ํ•ด์„œ๋Š” ์•Œ...
The commercial MNPs used activated microglial phagocytosis in both disperse and organotypic culture systems. It can be assumed that in vivo application would induce immune system reactivity, too. Because of this, their usefulness for in vivo neuroscientific implementations can be questioned. Future studies will need to...
์ƒ์—…์šฉ MNPs๋Š” ๋ถ„์‚ฐ ๋ฐฐ์–‘ ์‹œ์Šคํ…œ๊ณผ ์œ ๊ธฐ ๋ฐฐ์–‘ ์‹œ์Šคํ…œ ๋ชจ๋‘์—์„œ ํ™œ์„ฑํ™”๋œ ๋ฏธ์„ธ์•„๊ต์„ธํฌ ์‹์„ธํฌ ์ž‘์šฉ์„ ์‚ฌ์šฉํ–ˆ์Šต๋‹ˆ๋‹ค. ์ƒ์ฒด ๋‚ด ์ ์šฉ์ด ๋ฉด์—ญ ์ฒด๊ณ„ ๋ฐ˜์‘์„ฑ์„ ์œ ๋„ํ•  ๊ฒƒ์ด๋ผ๊ณ  ๊ฐ€์ •ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ด ๋•Œ๋ฌธ์— ์ƒ์ฒด ๋‚ด ์‹ ๊ฒฝ๊ณผํ•™ ๊ตฌํ˜„์— ๋Œ€ํ•œ ์œ ์šฉ์„ฑ์— ์˜๋ฌธ์„ ์ œ๊ธฐํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ํ–ฅํ›„ ์—ฐ๊ตฌ์—์„œ๋Š” ์„ธํฌ ํŠน์ด์  ํƒ€๊ฒŸํŒ… ์ „๋žต์„ ์‚ฌ์šฉํ•˜์—ฌ ์ด ๋ฌธ์ œ๋ฅผ ๊ทน๋ณตํ•ด์•ผ ํ•  ๊ฒƒ์ž…๋‹ˆ๋‹ค. ๋˜ํ•œ PC12 ์„ธํฌ๊ฐ€ 1์ฐจ ๋‰ด๋Ÿฐ๋ณด๋‹ค ํ›จ์”ฌ ๋” ๋งŽ์€ MNPs๋ฅผ ์ฐจ์ง€ํ•œ๋‹ค๋Š” ์‚ฌ์‹ค์„ ๋ฐœ๊ฒฌํ–ˆ์Šต๋‹ˆ๋‹ค. ์ด ์ฐจ์ด๋Š” PC12 ์„ธํฌ๊ฐ€ ๋‚˜๋…ธ ์ž…์ž์˜ ์ž์—ฐ์Šค๋Ÿฌ์šด ์‹ ๊ฒฝ ํก์ˆ˜์— ์ ํ•ฉํ•œ ๋ชจ๋ธ์ด ์•„๋‹ˆ๋ฉฐ, PC12 ์„ธํฌ์˜ ์ด์ „ ๊ฒฐ๊ณผ๋ฅผ ์ถฉ์กฑํ•œ๋‹ค๋Š” ๊ฒƒ...
22,428,801
Are supragastric belches the main determinants of troublesome belching symptoms in patients with gastro-oesophageal reflux disease?
{ "contexts": [ "Patients with gastro-oesophageal reflux disease (GERD) frequently report excessive belching but it is not known what determines the severity of these complaints.", "To determine what causes troublesome belching symptoms in GERD patients.", "We included 90 consecutive patients who were ref...
The type of belch determines the burden of belching complaints in patients with GERD. Supragastric belches, not gastric belches determine the severity of belching complaints.
yes
pub_med_qa40018
[ { "content": "์œ„์‹๋„ ์—ญ๋ฅ˜ ์งˆํ™˜ ํ™˜์ž์—์„œ ์œ„์ƒ๋ถ€ ํŠธ๋ฆผ์ด ๋ฌธ์ œ์„ฑ ํŠธ๋ฆผ ์ฆ์ƒ์˜ ์ฃผ์š” ๊ฒฐ์ • ์š”์ธ์ž…๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์œ„์‹๋„ ์—ญ๋ฅ˜ ์งˆํ™˜(GERD) ํ™˜์ž๋“ค์€ ์ข…์ข… ๊ณผ๋„ํ•œ ํŠธ๋ฆผ์„ ๋ณด๊ณ ํ•˜์ง€๋งŒ, ์ด๋Ÿฌํ•œ ๋ถˆ๋งŒ์˜ ์‹ฌ๊ฐ์„ฑ์„ ๊ฒฐ์ •ํ•˜๋Š” ์š”์ธ์ด ๋ฌด์—‡์ธ์ง€๋Š” ์•Œ๋ ค์ ธ ์žˆ์ง€ ์•Š์Šต๋‹ˆ๋‹ค.\n\n2)\nGERD ํ™˜์ž์—๊ฒŒ ๋ฌธ์ œ๊ฐ€ ๋˜๋Š” ํŠธ๋ฆผ ์ฆ์ƒ์„ ์œ ๋ฐœํ•˜๋Š” ์›์ธ์„ ํ™•์ธํ•ฉ๋‹ˆ๋‹ค.\n\n3)\n์—ญ๋ฅ˜ ์ฆ์ƒ ๋ถ„์„์˜ ์ผํ™˜์œผ๋กœ ์™ธ๋ž˜ 24์‹œ๊ฐ„ pH ์ž„ํ”ผ๋˜์Šค ์ธก์ •์„ ์œ„ํ•ด ์˜๋ขฐ๋œ 90๋ช…์˜ ์—ฐ์† ํ™˜์ž๋ฅผ ํฌํ•จ์‹œ์ผฐ์Šต๋‹ˆ๋‹ค....
The type of belch determines the burden of belching complaints in patients with GERD. Supragastric belches, not gastric belches determine the severity of belching complaints.
ํŠธ๋ฆผ ์œ ํ˜•์€ GERD ํ™˜์ž์˜ ํŠธ๋ฆผ ๋ถˆ๋งŒ ๋ถ€๋‹ด์„ ๊ฒฐ์ •ํ•ฉ๋‹ˆ๋‹ค. ์œ„ ํŠธ๋ฆผ์ด ์•„๋‹Œ ์œ„ ํŠธ๋ฆผ์ด ํŠธ๋ฆผ ๋ถˆ๋งŒ์˜ ์‹ฌ๊ฐ์„ฑ์„ ๊ฒฐ์ •ํ•ฉ๋‹ˆ๋‹ค.
22,428,038
Is activation of PI3K/AKT and MAPK pathway through a PDGFRฮฒ-dependent feedback loop involved in rapamycin resistance in hepatocellular carcinoma?
{ "contexts": [ "Rapamycin is an attractive approach for the treatment and prevention of HCC recurrence after liver transplantation. However, the objective response rates of rapamycin achieved with single-agent therapy were modest, supporting that rapamycin resistance is a frequently observed characteristic of ma...
Activation of PI3K/AKT and MAPK pathway through a PDGFRฮฒ-dependent feedback loop compromises the anti-tumor activity of rapamycin in HCC, and blockade of this feedback loop by sorafenib is an attractive approach to improve the anti-tumor effect of rapamycin, particularly in preventing or treating HCC recurrence after l...
yes
pub_med_qa40019
[ { "content": "PDGFRฮฒ ์˜์กด์„ฑ ํ”ผ๋“œ๋ฐฑ ๋ฃจํ”„๋ฅผ ํ†ตํ•œ PI3K/AKT ๋ฐ MAPK ๊ฒฝ๋กœ์˜ ํ™œ์„ฑํ™”๊ฐ€ ๊ฐ„์„ธํฌ์•”์ข…์—์„œ ๋ผํŒŒ๋งˆ์ด์‹  ์ €ํ•ญ์„ฑ์— ๊ด€์—ฌํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๋ผํŒŒ๋งˆ์ด์‹ ์€ ๊ฐ„ ์ด์‹ ํ›„ ๊ฐ„์„ธํฌ์•”(HCC) ์žฌ๋ฐœ์˜ ์น˜๋ฃŒ์™€ ์˜ˆ๋ฐฉ์„ ์œ„ํ•œ ๋งค๋ ฅ์ ์ธ ์ ‘๊ทผ๋ฒ•์ž…๋‹ˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ๋‹จ์ผ ์•ฝ์ œ ์š”๋ฒ•์œผ๋กœ ๋‹ฌ์„ฑ๋œ ๋ผํŒŒ๋งˆ์ด์‹ ์˜ ๊ฐ๊ด€์ ์ธ ๋ฐ˜์‘๋ฅ ์€ ๋ฏธ๋ฏธํ•˜์—ฌ ๋ผํŒŒ๋งˆ์ด์‹  ์ €ํ•ญ์„ฑ์ด ๋งŽ์€ ์•”์—์„œ ์ž์ฃผ ๊ด€์ฐฐ๋˜๋Š” ํŠน์ง•์ž„์„ ๋’ท๋ฐ›์นจํ•ฉ๋‹ˆ๋‹ค. ์ผ๋ถ€ ์—ฐ๊ตฌ๋Š” ๋ผํŒŒ๋งˆ์ด์‹  ์ €ํ•ญ์„ฑ์˜ ๋ฉ”์ปค๋‹ˆ์ฆ˜์„ ์ดํ•ดํ•˜๋Š” ๋ฐ ์ „๋…ํ•ด ์™”์ง€๋งŒ...
Activation of PI3K/AKT and MAPK pathway through a PDGFRฮฒ-dependent feedback loop compromises the anti-tumor activity of rapamycin in HCC, and blockade of this feedback loop by sorafenib is an attractive approach to improve the anti-tumor effect of rapamycin, particularly in preventing or treating HCC recurrence after l...
PDGFRฮฒ ์˜์กด์„ฑ ํ”ผ๋“œ๋ฐฑ ๋ฃจํ”„๋ฅผ ํ†ตํ•ด PI3K/AKT ๋ฐ MAPK ๊ฒฝ๋กœ๋ฅผ ํ™œ์„ฑํ™”ํ•˜๋ฉด ๊ฐ„์„ธํฌ์•”์ข…(HCC)์—์„œ ๋ผํŒŒ๋งˆ์ด์‹ ์˜ ํ•ญ์ข…์–‘ ํ™œ์„ฑ์ด ์ €ํ•˜๋˜๋ฉฐ, ์†Œ๋ผํŽ˜๋‹™์— ์˜ํ•œ ์ด ํ”ผ๋“œ๋ฐฑ ๋ฃจํ”„ ์ฐจ๋‹จ์€ ํŠนํžˆ ๊ฐ„ ์ด์‹ ํ›„ ๊ฐ„์„ธํฌ์•”์ข… ์žฌ๋ฐœ์„ ์˜ˆ๋ฐฉํ•˜๊ฑฐ๋‚˜ ์น˜๋ฃŒํ•˜๋Š” ๋ฐ ์žˆ์–ด ๋ผํŒŒ๋งˆ์ด์‹ ์˜ ํ•ญ์ข…์–‘ ํšจ๊ณผ๋ฅผ ๊ฐœ์„ ํ•˜๋Š” ๋งค๋ ฅ์ ์ธ ์ ‘๊ทผ๋ฒ•์ž…๋‹ˆ๋‹ค.
22,417,823
'm `` I afraid of those ones just 'cause they 've been prescribed '' : perceptions of risk among illicit users of pharmaceutical opioids?
{ "contexts": [ "There has been a rise in the illicit use of pharmaceutical opioids (\"pain pills\") in the United States. Conducted with young adult non-medical users of pharmaceutical opioids, this study uses qualitative methods and cultural consensus analysis to describe risk perceptions associated with pharma...
This study highlights potential problems with universal approaches to substance use prevention and intervention among young people since such approaches ignore the fact that substance use education messages may be experienced differently depending on an individual's drug use history and his/her perceptions of drug risk...
no
pub_med_qa40020
[ { "content": "'์˜์•ฝํ’ˆ ์˜คํ”ผ์˜ค์ด๋“œ์˜ ๋ถˆ๋ฒ• ์‚ฌ์šฉ์ž๋“ค ์‚ฌ์ด์—์„œ ์œ„ํ—˜์— ๋Œ€ํ•œ ์ธ์‹์€ '์ฒ˜๋ฐฉ๋˜์—ˆ๊ธฐ ๋•Œ๋ฌธ์— ๊ทธ๋Ÿฐ ๊ฒƒ๋“ค์ด ๋‘๋ ต์Šต๋‹ˆ๋‹ค'์ž…๋‹ˆ๋‹ค?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๋ฏธ๊ตญ์—์„œ ์˜์•ฝํ’ˆ ์˜คํ”ผ์˜ค์ด๋“œ(\"ํ†ต์ฆ์ œ\")์˜ ๋ถˆ๋ฒ• ์‚ฌ์šฉ์ด ์ฆ๊ฐ€ํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ๋Š” ์ Š์€ ์„ฑ์ธ ๋น„์˜๋ฃŒ ์‚ฌ์šฉ์ž๋ฅผ ๋Œ€์ƒ์œผ๋กœ ์ˆ˜ํ–‰๋˜์—ˆ์œผ๋ฉฐ, ์งˆ์  ๋ฐฉ๋ฒ•๊ณผ ๋ฌธํ™”์  ํ•ฉ์˜ ๋ถ„์„์„ ์‚ฌ์šฉํ•˜์—ฌ ์˜์•ฝํ’ˆ ์˜คํ”ผ์˜ค์ด๋“œ์™€ ๊ด€๋ จ๋œ ์œ„ํ—˜ ์ธ์‹์„ ์„ค๋ช…ํ•˜๊ณ  ์ด๋Ÿฌํ•œ ๊ฒฌํ•ด์˜ ๋ฌธํ™”์  ๊ณต์œ  ํŒจํ„ด๊ณผ ๋ฌธํ™” ๋‚ด ๋ณ€์ด๋ฅผ ํ™•์ธํ•ฉ๋‹ˆ๋‹ค.\n\n2)\n์งˆ์  ํ•˜์œ„ ํ‘œ๋ณธ(...
This study highlights potential problems with universal approaches to substance use prevention and intervention among young people since such approaches ignore the fact that substance use education messages may be experienced differently depending on an individual's drug use history and his/her perceptions of drug risk...
์ด ์—ฐ๊ตฌ๋Š” ์•ฝ๋ฌผ ์‚ฌ์šฉ ์˜ˆ๋ฐฉ ๋ฐ ๊ฐœ์ž…์— ๋Œ€ํ•œ ๋ณดํŽธ์ ์ธ ์ ‘๊ทผ ๋ฐฉ์‹์ด ์ Š์€์ด๋“ค ์‚ฌ์ด์—์„œ ์ž ์žฌ์ ์ธ ๋ฌธ์ œ๋ฅผ ๊ฐ•์กฐํ•ฉ๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ์ ‘๊ทผ ๋ฐฉ์‹์€ ๊ฐœ์ธ์˜ ์•ฝ๋ฌผ ์‚ฌ์šฉ ์ด๋ ฅ๊ณผ ์•ฝ๋ฌผ ์œ„ํ—˜์— ๋Œ€ํ•œ ์ธ์‹์— ๋”ฐ๋ผ ์•ฝ๋ฌผ ์‚ฌ์šฉ ๊ต์œก ๋ฉ”์‹œ์ง€๋ฅผ ๋‹ค๋ฅด๊ฒŒ ๊ฒฝํ—˜ํ•  ์ˆ˜ ์žˆ๋‹ค๋Š” ์‚ฌ์‹ค์„ ๋ฌด์‹œํ•˜๊ธฐ ๋•Œ๋ฌธ์ž…๋‹ˆ๋‹ค. ์—ฌ๊ธฐ์— ๋ณด๊ณ ๋œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” ์ง„ํ†ต์ œ์˜ ๋ถˆ๋ฒ• ์‚ฌ์šฉ์œผ๋กœ ์ธํ•œ ํ”ผํ•ด๋ฅผ ์ค„์ด๊ธฐ ์œ„ํ•œ ์˜ˆ๋ฐฉ ๋ฐ ๊ฐœ์ž… ํ”„๋กœ๊ทธ๋žจ ๊ฐœ๋ฐœ์— ์œ ์šฉํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
22,429,179
Do video-based cases disrupt deep critical thinking in problem-based learning?
{ "contexts": [ "โ€‚ Video is a popular tool in problem-based learning (PBL), although its production requires resources and time. Few studies have examined the impact of the use of video in PBL upon cognitive processes and critical thinking. Those that have done focused on cases involving physical signs, where vid...
โ€‚ Students and their tutors prefer video-based cases in PBL. However, compared with text-based material, the use of video-based material that refers to cases without dynamic physical signs is associated with a reduction in deep thinking.
yes
pub_med_qa40021
[ { "content": "๋น„๋””์˜ค ๊ธฐ๋ฐ˜ ์‚ฌ๋ก€๊ฐ€ ๋ฌธ์ œ ๊ธฐ๋ฐ˜ ํ•™์Šต์—์„œ ๊นŠ์€ ๋น„ํŒ์  ์‚ฌ๊ณ ๋ฅผ ๋ฐฉํ•ดํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "๋น„๋””์˜ค ๊ธฐ๋ฐ˜ ์‚ฌ๋ก€๊ฐ€ ๋ฌธ์ œ ๊ธฐ๋ฐ˜ ํ•™์Šต์—์„œ ๊นŠ์€ ๋น„ํŒ์  ์‚ฌ๊ณ ๋ฅผ ๋ฐฉํ•ดํ•ฉ๋‹ˆ๊นŒ?", "role": "passage" } ]
โ€‚ Students and their tutors prefer video-based cases in PBL. However, compared with text-based material, the use of video-based material that refers to cases without dynamic physical signs is associated with a reduction in deep thinking.
ํ•™์ƒ๊ณผ ํŠœํ„ฐ๋Š” PBL์—์„œ ๋น„๋””์˜ค ๊ธฐ๋ฐ˜ ์‚ฌ๋ก€๋ฅผ ์„ ํ˜ธํ•ฉ๋‹ˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ํ…์ŠคํŠธ ๊ธฐ๋ฐ˜ ์ž๋ฃŒ์— ๋น„ํ•ด ๋™์  ์‹ ์ฒด ์ง•ํ›„๊ฐ€ ์—†๋Š” ์‚ฌ๋ก€๋ฅผ ์ง€์นญํ•˜๋Š” ๋น„๋””์˜ค ๊ธฐ๋ฐ˜ ์ž๋ฃŒ์˜ ์‚ฌ์šฉ์€ ๊นŠ์€ ์‚ฌ๊ณ ์˜ ๊ฐ์†Œ์™€ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๋‹ค.
22,441,698
Does perfluorooctane sulfonate increase ฮฒ-oxidation of palmitic acid in chicken liver?
{ "contexts": [ "Perfluorooctane sulfonate (PFOS) belongs to a group of chemicals called perfluoroalkyl acids that have been extensively used in various applications such as stain and oil resistant treatments for fabrics, fire-fighting foams, and insecticides. These chemicals present an environmental and health r...
The administered doses in which effects are seen are around and even lower than the levels that can be found in wild populations of birds. General population human levels are a factor of two to three times lower than the LOEL value of this study. The environmental contamination of PFOS therefore presents a possibility ...
yes
pub_med_qa40022
[ { "content": "ํผํ”Œ๋ฃจ์˜ค๋กœ์˜ฅํƒ„ ์„คํฐ์‚ฐ์—ผ์ด ๋‹ญ ๊ฐ„์—์„œ ํŒ”๋ฏธํŠธ์‚ฐ์˜ ฮฒ ์‚ฐํ™”๋ฅผ ์ฆ๊ฐ€์‹œํ‚ค๋‚˜์š”?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\nํผํ”Œ๋ฃจ์˜ค๋กœ์˜ฅํƒ„ ์„คํฐ์‚ฐ์—ผ(PFOS)์€ ํผํ”Œ๋ฃจ์˜ค๋กœ์•Œํ‚ฌ์‚ฐ์ด๋ผ๋Š” ํ™”ํ•™๋ฌผ์งˆ ๊ทธ๋ฃน์— ์†ํ•˜๋ฉฐ, ์ง๋ฌผ, ์†Œํ™” ํผ, ์‚ด์ถฉ์ œ์˜ ์–ผ๋ฃฉ ๋ฐ ๋‚ด์œ ์„ฑ ์ฒ˜๋ฆฌ ๋“ฑ ๋‹ค์–‘ํ•œ ์‘์šฉ ๋ถ„์•ผ์—์„œ ๊ด‘๋ฒ”์œ„ํ•˜๊ฒŒ ์‚ฌ์šฉ๋˜์–ด ์™”์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ํ™”ํ•™๋ฌผ์งˆ๋“ค์€ ์•ผ์ƒ๋™๋ฌผ๊ณผ ์ธ๊ฐ„ ๋ชจ๋‘์—๊ฒŒ ๋งŽ์€ ์ƒ˜ํ”Œ์—์„œ ํ™˜๊ฒฝ์  ๋ฐ ๊ฑด๊ฐ•์ƒ์˜ ์œ„ํ—˜์„ ์ดˆ๋ž˜ํ•ฉ๋‹ˆ๋‹ค. ๋ณธ ์—ฐ๊ตฌ์—์„œ๋Š” ๋ฐœ๋‹ฌ ์ค‘์ธ ๋‹ญ ๋ฐฐ์•„์—์„œ ์ง€๋ฐฉ์‚ฐ ฮฒ ์‚ฐํ™”์— ๋Œ€ํ•œ PFOS์˜ ์˜ํ–ฅ์„ ...
The administered doses in which effects are seen are around and even lower than the levels that can be found in wild populations of birds. General population human levels are a factor of two to three times lower than the LOEL value of this study. The environmental contamination of PFOS therefore presents a possibility ...
ํšจ๊ณผ๊ฐ€ ๋‚˜ํƒ€๋‚˜๋Š” ํˆฌ์—ฌ ์šฉ๋Ÿ‰์€ ์•ผ์ƒ ์กฐ๋ฅ˜ ๊ฐœ์ฒด๊ตฐ์—์„œ ๋ฐœ๊ฒฌ๋˜๋Š” ์ˆ˜์ค€๋ณด๋‹ค ๋น„์Šทํ•˜๊ฑฐ๋‚˜ ๋” ๋‚ฎ์Šต๋‹ˆ๋‹ค. ์ผ๋ฐ˜ ๊ฐœ์ฒด๊ตฐ์˜ ์ธ๊ฐ„ ์ˆ˜์ค€์€ ์ด ์—ฐ๊ตฌ์˜ LOEL ๊ฐ’๋ณด๋‹ค 2~3๋ฐฐ ๋‚ฎ์Šต๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ PFOS์˜ ํ™˜๊ฒฝ ์˜ค์—ผ์€ ์•ผ์ƒ ์กฐ๋ฅ˜ ๊ฐœ์ฒด๊ตฐ์—์„œ ์˜ํ–ฅ์„ ๋ฏธ์น  ๊ฐ€๋Šฅ์„ฑ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
22,440,891
Are infection-related hospitalizations associated with increased mortality in patients with inflammatory bowel diseases?
{ "contexts": [ "Serious infections are an important side effect of immunosuppressive therapy used to treat Crohn's disease (CD) and ulcerative colitis (UC). There have been no nationally representative studies examining the spectrum of infection related hospitalizations in patients with IBD.", "Our study con...
Infections account for significant morbidity and mortality in patients with IBD and disproportionately impact older IBD patients with greater co-morbidity. Pneumonia, sepsis and C difficile infection are associated with the greatest excess mortality risk.
yes
pub_med_qa40023
[ { "content": "์—ผ์ฆ์„ฑ ์žฅ์งˆํ™˜ ํ™˜์ž์—์„œ ๊ฐ์—ผ ๊ด€๋ จ ์ž…์›์ด ์‚ฌ๋ง๋ฅ  ์ฆ๊ฐ€์™€ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์—ผ์ฆ์„ฑ ์žฅ์งˆํ™˜ ํ™˜์ž์—์„œ ๊ฐ์—ผ ๊ด€๋ จ ์ž…์›์ด ์‚ฌ๋ง๋ฅ  ์ฆ๊ฐ€์™€ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "passage" } ]
Infections account for significant morbidity and mortality in patients with IBD and disproportionately impact older IBD patients with greater co-morbidity. Pneumonia, sepsis and C difficile infection are associated with the greatest excess mortality risk.
๊ฐ์—ผ์€ IBD ํ™˜์ž์—์„œ ์‹ฌ๊ฐํ•œ ์ดํ™˜์œจ๊ณผ ์‚ฌ๋ง๋ฅ ์„ ์ฐจ์ง€ํ•˜๋ฉฐ, ๋™๋ฐ˜ ์งˆํ™˜์ด ๋” ํฐ ๊ณ ๋ น IBD ํ™˜์ž์—๊ฒŒ ๋ถˆ๊ท ํ˜•์ ์œผ๋กœ ์˜ํ–ฅ์„ ๋ฏธ์นฉ๋‹ˆ๋‹ค. ํ๋ ด, ํŒจํ˜ˆ์ฆ ๋ฐ Cํ˜• ๋””ํ”ผ์‹ค ๊ฐ์—ผ์€ ๊ฐ€์žฅ ํฐ ์ดˆ๊ณผ ์‚ฌ๋ง ์œ„ํ—˜๊ณผ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๋‹ค.
22,417,945
Is the G894T polymorphism on endothelial nitric oxide synthase gene associated with increased coronary heart disease among Asia population : evidence from a Meta analysis?
{ "contexts": [ "Growing studies have revealed the underlying association between eNOS 894G/T (rs1799983) polymorphism and coronary heart disease (CHD) among Asia population. Results from these studies remained conflicting. We conducted this meta-analysis to estimate the overall CHD risk of eNOS 894G/T polymorphi...
This meta-analysis indicated that eNOS 894G/T polymorphism may play an important role in CHD development among Asia population.
yes
pub_med_qa40024
[ { "content": "๋‚ดํ”ผ ์‚ฐํ™”์งˆ์†Œ ํ•ฉ์„ฑํšจ์†Œ ์œ ์ „์ž์˜ G894T ๋‹คํ˜•์„ฑ์ด ์•„์‹œ์•„ ์ธ๊ตฌ์˜ ๊ด€์ƒ๋™๋งฅ ์‹ฌ์žฅ ์งˆํ™˜ ์ฆ๊ฐ€์™€ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๊นŒ? ๋ฉ”ํƒ€ ๋ถ„์„์˜ ์ฆ๊ฑฐ๋Š”?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์„ฑ์žฅํ•˜๋Š” ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ์•„์‹œ์•„ ์ธ๊ตฌ์—์„œ eNOS 894G/T(rs1799983) ๋‹คํ˜•์„ฑ๊ณผ ๊ด€์ƒ๋™๋งฅ ์‹ฌ์žฅ ์งˆํ™˜(CHD) ์‚ฌ์ด์˜ ๊ทผ๋ณธ์ ์ธ ์—ฐ๊ด€์„ฑ์ด ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” ์—ฌ์ „ํžˆ ์ƒ๋ฐ˜๋œ ๊ฒฐ๊ณผ๋ฅผ ๋ณด์˜€์Šต๋‹ˆ๋‹ค. ์šฐ๋ฆฌ๋Š” ์•„์‹œ์•„ ์ธ๊ตฌ์— ๋Œ€ํ•œ eNOS 894G/T ๋‹คํ˜•์„ฑ์˜ ์ „๋ฐ˜์ ์ธ CHD ์œ„ํ—˜์„ ์ถ”์ •ํ•˜๊ธฐ ์œ„...
This meta-analysis indicated that eNOS 894G/T polymorphism may play an important role in CHD development among Asia population.
์ด ๋ฉ”ํƒ€ ๋ถ„์„์€ eNOS 894G/T ๋‹คํ˜•์„ฑ์ด ์•„์‹œ์•„ ์ธ๊ตฌ์˜ ๋งŒ์„ฑ ํ์‡„์„ฑ ํ์งˆํ™˜(CHD) ๋ฐœ๋ณ‘์— ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•  ์ˆ˜ ์žˆ์Œ์„ ๋‚˜ํƒ€๋ƒˆ์Šต๋‹ˆ๋‹ค.
22,424,294
Do leukotrienes inhibit early stages of HIV-1 infection in monocyte-derived microglia-like cells?
{ "contexts": [ "Microglia are one of the main cell types to be productively infected by HIV-1 in the central nervous system (CNS). Leukotriene B4 (LTB4) and cysteinyl-leukotrienes such as LTC4 are some of the proinflammatory molecules produced in infected individuals that contribute to neuroinflammation. We ther...
These data show for the first time that LTs influence microglial cell infection by HIV-1, and may be a factor in the control of viral load in the CNS.
yes
pub_med_qa40025
[ { "content": "๋ฅ˜์ฝ”ํŠธ๋ฆฌ์—”์€ ๋‹จํ•ต๊ตฌ ์œ ๋ž˜ ๋ฏธ์„ธ์•„๊ต์„ธํฌ ์œ ์‚ฌ ์„ธํฌ์—์„œ HIV-1 ๊ฐ์—ผ์˜ ์ดˆ๊ธฐ ๋‹จ๊ณ„๋ฅผ ์–ต์ œํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๋ฏธ์„ธ์•„๊ต์„ธํฌ๋Š” ์ค‘์ถ”์‹ ๊ฒฝ๊ณ„(CNS)์—์„œ HIV-1์— ์˜ํ•ด ์ƒ์‚ฐ์ ์œผ๋กœ ๊ฐ์—ผ๋˜๋Š” ์ฃผ์š” ์„ธํฌ ์œ ํ˜• ์ค‘ ํ•˜๋‚˜์ž…๋‹ˆ๋‹ค. ๋ฅ˜์ฝ”ํŠธ๋ฆฌ์—” B4(LTB4)์™€ LTC4์™€ ๊ฐ™์€ ์‹œ์Šคํ…Œ๋‹-๋ฅ˜์ฝ”ํŠธ๋ฆฌ์—”์€ ๊ฐ์—ผ๋œ ์‚ฌ๋žŒ๋“ค์—๊ฒŒ์„œ ์ƒ์„ฑ๋˜๋Š” ์—ผ์ฆ์„ฑ ๋ถ„์ž ์ค‘ ์ผ๋ถ€๋กœ, ์‹ ๊ฒฝ ์—ผ์ฆ์— ๊ธฐ์—ฌํ•ฉ๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ ์šฐ๋ฆฌ๋Š” ๋ฏธ์„ธ์•„๊ต์„ธํฌ์˜ HIV-1 ๊ฐ์—ผ์—์„œ ๋ฅ˜์ฝ”ํŠธ๋ฆฌ์—”(LTs)์˜ ์—ญํ• ์„ ์กฐ์‚ฌํ•˜๊ณ ์ž ...
These data show for the first time that LTs influence microglial cell infection by HIV-1, and may be a factor in the control of viral load in the CNS.
์ด ๋ฐ์ดํ„ฐ๋Š” ์ฒ˜์Œ์œผ๋กœ LT๊ฐ€ HIV-1์— ์˜ํ•œ ๋ฏธ์„ธ์•„๊ต์„ธํฌ ๊ฐ์—ผ์— ์˜ํ–ฅ์„ ๋ฏธ์น˜๋ฉฐ, ์ค‘์ถ”์‹ ๊ฒฝ๊ณ„์˜ ๋ฐ”์ด๋Ÿฌ์Šค ๋ถ€ํ•˜๋ฅผ ์กฐ์ ˆํ•˜๋Š” ์š”์ธ์ด ๋  ์ˆ˜ ์žˆ์Œ์„ ๋ณด์—ฌ์ค๋‹ˆ๋‹ค.
22,424,291
Is gCS overexpression associated with multidrug resistance of human HCT-8 colon cancer cells?
{ "contexts": [ "Multidrug resistance is one of the main impediments to the successful treatment of colon cancer. Glucosylceramide synthase (GCS) which is related to multidrug resistance (MDR) can reduce the level of ceramide and can help cells escape from the ceramide-induced cell apoptosis. However, the underly...
In conclusion, our research indicated that suppression of GCS restores the sensitivity of multidrug resistance colon cancer cells to drug treatment.
yes
pub_med_qa40026
[ { "content": "gCS ๊ณผ๋ฐœํ˜„์ด ์ธ๊ฐ„ HCT-8 ๋Œ€์žฅ์•” ์„ธํฌ์˜ ๋‹ค์ œ๋‚ด์„ฑ๊ณผ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "user" }, { "content": "gCS ๊ณผ๋ฐœํ˜„์ด ์ธ๊ฐ„ HCT-8 ๋Œ€์žฅ์•” ์„ธํฌ์˜ ๋‹ค์ œ๋‚ด์„ฑ๊ณผ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "passage" } ]
In conclusion, our research indicated that suppression of GCS restores the sensitivity of multidrug resistance colon cancer cells to drug treatment.
๊ฒฐ๋ก ์ ์œผ๋กœ, ์šฐ๋ฆฌ์˜ ์—ฐ๊ตฌ๋Š” GCS ์–ต์ œ๊ฐ€ ๋‹ค์ œ๋‚ด์„ฑ ๋Œ€์žฅ์•” ์„ธํฌ์˜ ์•ฝ๋ฌผ ์น˜๋ฃŒ์— ๋Œ€ํ•œ ๋ฏผ๊ฐ์„ฑ์„ ํšŒ๋ณต์‹œํ‚จ๋‹ค๋Š” ๊ฒƒ์„ ๋ณด์—ฌ์ฃผ์—ˆ์Šต๋‹ˆ๋‹ค.
22,422,563
Do cognitive processes mediate the relation between mindfulness and social anxiety within a clinical sample?
{ "contexts": [ "The researchers investigated the relation between mindfulness and social anxiety symptoms, and examined whether this relation is mediated by cognitive appraisals commonly associated with social anxiety.", "Ninety-eight individuals diagnosed with social phobia.", "Using a cross-sectional d...
Further research using a longitudinal design and other measures of mindfulness is needed to replicate these findings and further explicate the mechanism by which mindfulness might be associated with negative cognitive appraisals.
yes
pub_med_qa40027
[ { "content": "์ธ์ง€ ๊ณผ์ •์ด ์ž„์ƒ ์ƒ˜ํ”Œ ๋‚ด์—์„œ ๋งˆ์Œ์ฑ™๊น€๊ณผ ์‚ฌํšŒ์  ๋ถˆ์•ˆ ์‚ฌ์ด์˜ ๊ด€๊ณ„๋ฅผ ๋งค๊ฐœํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์—ฐ๊ตฌ์ง„์€ ๋งˆ์Œ์ฑ™๊น€๊ณผ ์‚ฌํšŒ ๋ถˆ์•ˆ ์ฆ์ƒ ๊ฐ„์˜ ๊ด€๊ณ„๋ฅผ ์กฐ์‚ฌํ•˜๊ณ , ์ด ๊ด€๊ณ„๊ฐ€ ์‚ฌํšŒ ๋ถˆ์•ˆ๊ณผ ํ”ํžˆ ์—ฐ๊ด€๋˜๋Š” ์ธ์ง€์  ํ‰๊ฐ€์— ์˜ํ•ด ๋งค๊ฐœ๋˜๋Š”์ง€ ์—ฌ๋ถ€๋ฅผ ์กฐ์‚ฌํ–ˆ์Šต๋‹ˆ๋‹ค.\n\n2)\n์‚ฌํšŒ ๊ณตํฌ์ฆ ์ง„๋‹จ์„ ๋ฐ›์€ 98๋ช….\n\n3)\nํšก๋‹จ๋ฉด ์„ค๊ณ„๋ฅผ ์‚ฌ์šฉํ•˜์—ฌ ์ผ๋ฐ˜ ์ตœ์†Œ ์ œ๊ณฑ ํšŒ๊ท€ ๋ถ„์„๊ณผ ๋ถ€ํŠธ์ŠคํŠธ๋ž˜ํ•‘ ๋งค๊ฐœ ๋ถ„์„์„ ์‚ฌ์šฉํ•˜์—ฌ ์—ฐ๊ตฌ ๊ฐ€์„ค์„ ํ…Œ์ŠคํŠธํ–ˆ์Šต๋‹ˆ๋‹ค.\n\n4)\n๋งˆ์Œ์ฑ™๊น€์€ ์‚ฌํšŒ ๋ถˆ์•ˆ...
Further research using a longitudinal design and other measures of mindfulness is needed to replicate these findings and further explicate the mechanism by which mindfulness might be associated with negative cognitive appraisals.
์ด๋Ÿฌํ•œ ๋ฐœ๊ฒฌ์„ ์žฌํ˜„ํ•˜๊ณ  ๋งˆ์Œ์ฑ™๊น€์ด ๋ถ€์ •์ ์ธ ์ธ์ง€ ํ‰๊ฐ€์™€ ์—ฐ๊ด€๋  ์ˆ˜ ์žˆ๋Š” ๋ฉ”์ปค๋‹ˆ์ฆ˜์„ ์ถ”๊ฐ€๋กœ ์„ค๋ช…ํ•˜๊ธฐ ์œ„ํ•ด ์ข…๋‹จ ์„ค๊ณ„ ๋ฐ ๊ธฐํƒ€ ๋งˆ์Œ์ฑ™๊น€ ์ธก์ •์„ ์‚ฌ์šฉํ•˜๋Š” ์ถ”๊ฐ€ ์—ฐ๊ตฌ๊ฐ€ ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.
22,426,130
Is pDGF-induced migration of vascular smooth muscle cells inhibited by heme oxygenase-1 via VEGFR2 upregulation and subsequent assembly of inactive VEGFR2/PDGFRฮฒ heterodimers?
{ "contexts": [ "In cardiovascular regulation, heme oxygenase-1 (HO-1) activity has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation by promoting cell cycle arrest at the G1/S phase. However, the effect of HO-1 on VSMC migration remains unclear. We aim to elucidate the mechanism by which HO-...
These findings identify a potent antimigratory function of HO-1 in VSMCs, a mechanism that involves VEGFA and VEGFR2 upregulation, followed by assembly of inactive VEGFR2/PDGFRฮฒ complexes that attenuates effective PDGFRฮฒ signaling.
yes
pub_med_qa40028
[ { "content": "ํ˜ˆ๊ด€ ํ‰ํ™œ๊ทผ ์„ธํฌ์˜ pDGF ์œ ๋„ ์ด๋™์ด VEGFR2 ์ƒํ–ฅ ์กฐ์ ˆ ๋ฐ ๋น„ํ™œ์„ฑ VEGFR2/PDGFRฮฒ ์ด์ข…์ดํ•ฉ์ฒด์˜ ์กฐ๋ฆฝ์„ ํ†ตํ•ด ํ—ด ์˜ฅ์‹œ๊ฒŒ๋‚˜์ œ-1์— ์˜ํ•ด ์–ต์ œ๋ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์‹ฌํ˜ˆ๊ด€ ์กฐ์ ˆ์—์„œ ํ—ด ์˜ฅ์‹œ๊ฒŒ๋‚˜์ œ-1(HO-1) ํ™œ์„ฑ์€ G1/S ๋‹จ๊ณ„์—์„œ ์„ธํฌ ์ฃผ๊ธฐ ์ •์ง€๋ฅผ ์ด‰์ง„ํ•˜์—ฌ ํ˜ˆ๊ด€ ํ‰ํ™œ๊ทผ ์„ธํฌ(VSMC) ์ฆ์‹์„ ์–ต์ œํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ HO-1์ด VSMC ์ด๋™์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์€ ์•„์ง ๋ช…ํ™•ํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ์šฐ๋ฆฌ๋Š” HO-1์ด PDGFBB์— ์˜ํ•ด...
These findings identify a potent antimigratory function of HO-1 in VSMCs, a mechanism that involves VEGFA and VEGFR2 upregulation, followed by assembly of inactive VEGFR2/PDGFRฮฒ complexes that attenuates effective PDGFRฮฒ signaling.
์ด๋Ÿฌํ•œ ๋ฐœ๊ฒฌ์€ VSMC์—์„œ HO-1์˜ ๊ฐ•๋ ฅํ•œ ํ•ญ์ด์ฃผ ๊ธฐ๋Šฅ์„ ์‹๋ณ„ํ•˜๋ฉฐ, ์ด๋Š” VEGFA์™€ VEGFR2์˜ ์ƒํ–ฅ ์กฐ์ ˆ์„ ํฌํ•จํ•˜๊ณ , ์ด์–ด์„œ ํšจ๊ณผ์ ์ธ PDGFRฮฒ ์‹ ํ˜ธ ์ „๋‹ฌ์„ ์•ฝํ™”์‹œํ‚ค๋Š” ๋น„ํ™œ์„ฑ VEGFR2/PDGFRฮฒ ๋ณตํ•ฉ์ฒด์˜ ์กฐ๋ฆฝ์„ ํฌํ•จํ•ฉ๋‹ˆ๋‹ค.
22,433,786
Does combined medical and surgical therapy improve olfaction in patients with nasal polyposis?
{ "contexts": [ "The aim of the present study was to evaluate the outcomes of combined oral steroid, nasal steroid and surgical therapy in patients with impaired olfaction due to nasal polyposis.", "This prospective observational study was undertaken in the otolaryngology department of a university hospital. ...
Combined therapy seems efficient in improving smell identification scores of nasal polyposis patients.
yes
pub_med_qa40029
[ { "content": "์˜๋ฃŒ ๋ฐ ์™ธ๊ณผ์  ์น˜๋ฃŒ๋ฅผ ๋ณ‘ํ–‰ํ•˜๋ฉด ๋น„๊ฐ• ์šฉ์ข…์ฆ ํ™˜์ž์˜ ํ›„๊ฐ์ด ๊ฐœ์„ ๋ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๋ณธ ์—ฐ๊ตฌ์˜ ๋ชฉ์ ์€ ๋น„๊ฐ• ์šฉ์ข…์ฆ์œผ๋กœ ์ธํ•ด ํ›„๊ฐ ๊ธฐ๋Šฅ์ด ์ €ํ•˜๋œ ํ™˜์ž๋“ค์„ ๋Œ€์ƒ์œผ๋กœ ๊ฒฝ๊ตฌ ์Šคํ…Œ๋กœ์ด๋“œ, ๋น„๊ฐ• ์Šคํ…Œ๋กœ์ด๋“œ ๋ฐ ์™ธ๊ณผ์  ์น˜๋ฃŒ๋ฅผ ๋ณ‘ํ–‰ํ•œ ๊ฒฐ๊ณผ๋ฅผ ํ‰๊ฐ€ํ•˜๋Š” ๊ฒƒ์ด์—ˆ์Šต๋‹ˆ๋‹ค.\n\n2)\n์ด ์ „ํ–ฅ์  ๊ด€์ฐฐ ์—ฐ๊ตฌ๋Š” ๋Œ€ํ•™๋ณ‘์› ์ด๋น„์ธํ›„๊ณผ์—์„œ ์ˆ˜ํ–‰๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ ๊ธฐ๊ฐ„ ๋™์•ˆ 19๋ช…์˜ ๋น„๊ฐ• ์šฉ์ข…์ฆ ํ™˜์ž๋ฅผ ๋Œ€์ƒ์œผ๋กœ ๊ตฌ๊ฐ• ์Šคํ…Œ๋กœ์ด๋“œ ์น˜๋ฃŒ ์ „, ์ˆ˜์ˆ  ์ „(์Šคํ…Œ๋กœ์ด๋“œ ์น˜๋ฃŒ ํ›„), ์ˆ˜์ˆ  ํ›„ ...
Combined therapy seems efficient in improving smell identification scores of nasal polyposis patients.
๋ณ‘์šฉ ์š”๋ฒ•์€ ๋น„๊ฐ• ์šฉ์ข…์ฆ ํ™˜์ž์˜ ํ›„๊ฐ ์‹๋ณ„ ์ ์ˆ˜๋ฅผ ํ–ฅ์ƒ์‹œํ‚ค๋Š” ๋ฐ ํšจ๊ณผ์ ์ธ ๊ฒƒ์œผ๋กœ ๋ณด์ž…๋‹ˆ๋‹ค.
22,417,489
Are lipid and cholesterol oxidation in chicken meat inhibited by sage but not by garlic?
{ "contexts": [ "The effects of the addition of sage and garlic in chicken meat on lipid and cholesterol oxidation, having as prooxidant factors the addition of salt, thermal treatment, and frozen storage, were evaluated. The content of unsaturated fatty acids did not change in the presence of sage; on the contra...
The addition of sage to chicken meat (0.1 g/100 g) is a good alternative to prevent and delay the formation of compounds derived from lipid oxidation that are responsible for off-flavors and loss of nutritional quality during long-term frozen storage. Care must be taken when using garlic to seasoning chicken meat produ...
yes
pub_med_qa40030
[ { "content": "๋‹ญ๊ณ ๊ธฐ์˜ ์ง€์งˆ๊ณผ ์ฝœ๋ ˆ์Šคํ…Œ๋กค ์‚ฐํ™”๋Š” ์„ธ์ด์ง€์— ์˜ํ•ด ์–ต์ œ๋˜์ง€๋งŒ ๋งˆ๋Š˜์—๋Š” ์–ต์ œ๋˜์ง€ ์•Š๋‚˜์š”?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๋‹ญ๊ณ ๊ธฐ์— ์„ธ์ด์ง€์™€ ๋งˆ๋Š˜์„ ์ฒจ๊ฐ€ํ•˜๋ฉด ์—ผ๋ถ„ ์ฒจ๊ฐ€, ์—ด์ฒ˜๋ฆฌ, ๋ƒ‰๋™ ๋ณด๊ด€ ๋“ฑ์ด ์ง€์งˆ ๋ฐ ์ฝœ๋ ˆ์Šคํ…Œ๋กค ์‚ฐํ™”์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์„ ํ‰๊ฐ€ํ–ˆ์Šต๋‹ˆ๋‹ค. ๋ถˆํฌํ™” ์ง€๋ฐฉ์‚ฐ์˜ ํ•จ๋Ÿ‰์€ ์„ธ์ด์ง€๊ฐ€ ์žˆ๋Š” ๊ฒฝ์šฐ ๋ณ€ํ™”ํ•˜์ง€ ์•Š์•˜์œผ๋ฉฐ, ๋ฐ˜๋Œ€๋กœ ๋งˆ๋Š˜์˜ ๊ฒฝ์šฐ ์กฐ๋ฆฌ ๋ฐ ๋ณด๊ด€ ํ›„ ์ง€๋ฐฉ์‚ฐ ํ•จ๋Ÿ‰์ด ๊ฐ์†Œํ–ˆ์Šต๋‹ˆ๋‹ค. ํ—ฅ์‚ฌ๋‚ ๊ณผ ํŽœํƒ€๋‚  ํ•จ๋Ÿ‰์€ ์„ธ์ด์ง€๊ฐ€ ํ•จ์œ ๋œ ํŒจํ‹ฐ์—์„œ ๋‚ฎ์•˜๊ณ  ๋งˆ๋Š˜์ด ํ•จ์œ ๋œ ํŒจํ‹ฐ์—์„œ ๋” ๋†’์•˜์Šต๋‹ˆ๋‹ค....
The addition of sage to chicken meat (0.1 g/100 g) is a good alternative to prevent and delay the formation of compounds derived from lipid oxidation that are responsible for off-flavors and loss of nutritional quality during long-term frozen storage. Care must be taken when using garlic to seasoning chicken meat produ...
๋‹ญ๊ณ ๊ธฐ์— ์„ธ์ด์ง€(0.1g/100g)๋ฅผ ์ฒจ๊ฐ€ํ•˜๋Š” ๊ฒƒ์€ ์žฅ๊ธฐ๊ฐ„ ๋ƒ‰๋™ ๋ณด๊ด€ ์‹œ ๋ง›์ด ๋‚˜์ง€ ์•Š๊ณ  ์˜์–‘ ํ’ˆ์งˆ์ด ์ €ํ•˜๋˜๋Š” ์ง€์งˆ ์‚ฐํ™”์—์„œ ์œ ๋ž˜ํ•œ ํ™”ํ•ฉ๋ฌผ์˜ ํ˜•์„ฑ์„ ๋ฐฉ์ง€ํ•˜๊ณ  ์ง€์—ฐ์‹œํ‚ค๋Š” ์ข‹์€ ๋Œ€์•ˆ์ž…๋‹ˆ๋‹ค. ํŠนํžˆ ํ–„๋ฒ„๊ฑฐ๋‚˜ ๋ฏธํŠธ๋ณผ๊ณผ ๊ฐ™์€ ๋‹ญ๊ณ ๊ธฐ ์ œํ’ˆ์„ ์–‘๋…ํ•  ๋•Œ๋Š” ๋งˆ๋Š˜์„ ์‚ฌ์šฉํ•  ๋•Œ ์ฃผ์˜ํ•ด์•ผ ํ•˜๋ฉฐ, ์ด๋Š” ์ง€์งˆ ์‚ฐํ™”๋ฅผ ์ด‰์ง„ํ•˜์—ฌ ์†Œ๋น„์ž๊ฐ€ ์ œํ’ˆ์„ ๊ฑฐ๋ถ€ํ•  ์œ„ํ—˜์„ ๋†’์ผ ์ˆ˜ ์žˆ๊ธฐ ๋•Œ๋ฌธ์ž…๋‹ˆ๋‹ค.
22,425,822
Does combining xenon and mild therapeutic hypothermia preserve neurological function after prolonged cardiac arrest in pigs?
{ "contexts": [ "Despite the introduction of mild therapeutic hypothermia into postcardiac arrest care, cerebral and myocardial injuries represent the limiting factors for survival after cardiac arrest. Administering xenon may confer an additional neuroprotective effect after successful cardiopulmonary resuscitat...
These results demonstrate that even a short exposure to xenon during induction of mild therapeutic hypothermia results in significant improvements in functional recovery and ameliorated myocardial dysfunction.
yes
pub_med_qa40031
[ { "content": "์ œ๋…ผ๊ณผ ๊ฒฝ์ฆ ์น˜๋ฃŒ์šฉ ์ €์ฒด์˜จ์ฆ์„ ๋ณ‘์šฉํ•˜๋ฉด ๋ผ์ง€์˜ ์žฅ๊ธฐ ์‹ฌ์ •์ง€ ํ›„ ์‹ ๊ฒฝ ๊ธฐ๋Šฅ์ด ์œ ์ง€๋ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ œ๋…ผ๊ณผ ๊ฒฝ์ฆ ์น˜๋ฃŒ์šฉ ์ €์ฒด์˜จ์ฆ์„ ๋ณ‘์šฉํ•˜๋ฉด ๋ผ์ง€์˜ ์žฅ๊ธฐ ์‹ฌ์ •์ง€ ํ›„ ์‹ ๊ฒฝ ๊ธฐ๋Šฅ์ด ์œ ์ง€๋ฉ๋‹ˆ๊นŒ?", "role": "passage" } ]
These results demonstrate that even a short exposure to xenon during induction of mild therapeutic hypothermia results in significant improvements in functional recovery and ameliorated myocardial dysfunction.
์ด ๊ฒฐ๊ณผ๋Š” ๊ฒฝ๋ฏธํ•œ ์น˜๋ฃŒ ์ €์ฒด์˜จ์ฆ ์œ ๋„ ์ค‘ ์ œ๋…ผ์— ์งง์€ ์‹œ๊ฐ„๋งŒ ๋…ธ์ถœ๋˜์–ด๋„ ๊ธฐ๋Šฅ ํšŒ๋ณต์ด ํฌ๊ฒŒ ๊ฐœ์„ ๋˜๊ณ  ์‹ฌ๊ทผ ๊ธฐ๋Šฅ ์žฅ์• ๊ฐ€ ๊ฐœ์„ ๋œ๋‹ค๋Š” ๊ฒƒ์„ ๋ณด์—ฌ์ค๋‹ˆ๋‹ค.
22,425,820
Do both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophy?
{ "contexts": [ "Previous workers have demonstrated that controlled mechanical ventilation results in diaphragm inactivity and elicits a rapid development of diaphragm weakness as a result of both contractile dysfunction and fiber atrophy. Limited data exist regarding the impact of pressure support ventilation, a...
High levels of prolonged pressure support ventilation promote diaphragmatic atrophy and contractile dysfunction. Furthermore, similar to controlled mechanical ventilation, pressure support ventilation-induced diaphragmatic atrophy and weakness are associated with both diaphragmatic oxidative stress and protease activat...
yes
pub_med_qa40032
[ { "content": "๊ณ ์•• ์ง€์ง€ ํ™˜๊ธฐ์™€ ์ œ์–ด๋œ ๊ธฐ๊ณ„ ํ™˜๊ธฐ ๋ชจ๋‘ ํšก๊ฒฉ๋ง‰ ๊ธฐ๋Šฅ ์žฅ์• ์™€ ์œ„์ถ•์„ ์œ ๋ฐœํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์ด์ „ ์—ฐ๊ตฌ์ž๋“ค์€ ๊ธฐ๊ณ„์  ํ™˜๊ธฐ๋ฅผ ์ œ์–ดํ•˜๋ฉด ๋‹ค์ด์–ดํ”„๋žจ์ด ๋น„ํ™œ์„ฑํ™”๋˜๊ณ  ์ˆ˜์ถ• ๊ธฐ๋Šฅ ์žฅ์• ์™€ ์„ฌ์œ  ์œ„์ถ•์œผ๋กœ ์ธํ•ด ๋‹ค์ด์–ดํ”„๋žจ ์•ฝํ™”๊ฐ€ ๋น ๋ฅด๊ฒŒ ๋ฐœ์ƒํ•œ๋‹ค๋Š” ๊ฒƒ์„ ์ž…์ฆํ–ˆ์Šต๋‹ˆ๋‹ค. ๋‹ค์ด์–ดํ”„๋žจ ์˜จ ๋‹ค์ด์–ดํ”„๋žจ ๊ตฌ์กฐ์™€ ๊ธฐ๋Šฅ์˜ ๋ถ€๋ถ„์ ์ธ ๊ธฐ๊ณ„์  ํ™œ๋™์„ ํ—ˆ์šฉํ•˜๋Š” ์ผ๋ฐ˜์ ์ธ ๊ธฐ๊ณ„์  ํ™˜๊ธฐ ๋ฐฉ์‹์ธ ์••๋ ฅ ์ง€์ง€ ํ™˜๊ธฐ์˜ ์˜ํ–ฅ์— ๋Œ€ํ•œ ๋ฐ์ดํ„ฐ๋Š” ์ œํ•œ์ ์ž…๋‹ˆ๋‹ค. ์šฐ๋ฆฌ๋Š” ๋ณธ ์—ฐ๊ตฌ๋ฅผ ํ†ตํ•ด ๋†’์€ ์ˆ˜์ค€์˜ ์••๋ ฅ ์ง€...
High levels of prolonged pressure support ventilation promote diaphragmatic atrophy and contractile dysfunction. Furthermore, similar to controlled mechanical ventilation, pressure support ventilation-induced diaphragmatic atrophy and weakness are associated with both diaphragmatic oxidative stress and protease activat...
๋†’์€ ์ˆ˜์ค€์˜ ์žฅ์‹œ๊ฐ„ ์••๋ ฅ ์ง€์ง€ ํ™˜๊ธฐ๋Š” ํšก๊ฒฉ๋ง‰ ์œ„์ถ•๊ณผ ์ˆ˜์ถ• ๊ธฐ๋Šฅ ์žฅ์• ๋ฅผ ์ด‰์ง„ํ•ฉ๋‹ˆ๋‹ค. ๋˜ํ•œ ์ œ์–ด๋œ ๊ธฐ๊ณ„์‹ ํ™˜๊ธฐ์™€ ์œ ์‚ฌํ•˜๊ฒŒ ์••๋ ฅ ์ง€์ง€ ํ™˜๊ธฐ๋กœ ์ธํ•œ ํšก๊ฒฉ๋ง‰ ์œ„์ถ•๊ณผ ์•ฝํ™”๋Š” ํšก๊ฒฉ๋ง‰ ์‚ฐํ™” ์ŠคํŠธ๋ ˆ์Šค์™€ ํ”„๋กœํ…Œ์•„์ œ ํ™œ์„ฑํ™” ๋ชจ๋‘์™€ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๋‹ค.
22,420,170
Is deletion allele of the ACE gene a risk factor for asthma predisposition?
{ "contexts": [ "Angiotensin-converting enzyme (ACE) has an important role in inactivation of bradykinin and tachykinins which known as powerful bronchoconstrictors. It has been demonstrated that an insertion (1)/deletion (D) genetic variations within the ACE gene greatly influence the plasma level of ACE.", ...
We have concluded that deletion allele of the ACE gene is not a risk factor for asthma predisposition.
no
pub_med_qa40033
[ { "content": "ACE ์œ ์ „์ž์˜ ๊ฒฐ์‹ค ๋Œ€๋ฆฝ ์œ ์ „์ž๊ฐ€ ์ฒœ์‹ ์†Œ์ธ์˜ ์œ„ํ—˜ ์š”์†Œ์ž…๋‹ˆ๊นŒ?", "role": "user" }, { "content": "ACE ์œ ์ „์ž์˜ ๊ฒฐ์‹ค ๋Œ€๋ฆฝ ์œ ์ „์ž๊ฐ€ ์ฒœ์‹ ์†Œ์ธ์˜ ์œ„ํ—˜ ์š”์†Œ์ž…๋‹ˆ๊นŒ?", "role": "passage" } ]
We have concluded that deletion allele of the ACE gene is not a risk factor for asthma predisposition.
ACE ์œ ์ „์ž์˜ ๊ฒฐ์‹ค ๋Œ€๋ฆฝ ์œ ์ „์ž๊ฐ€ ์ฒœ์‹ ์†Œ์ธ์˜ ์œ„ํ—˜ ์š”์†Œ๊ฐ€ ์•„๋‹ˆ๋ผ๋Š” ๊ฒฐ๋ก ์„ ๋‚ด๋ ธ์Šต๋‹ˆ๋‹ค.
22,446,619
Does a novel genome-based approach correlate TMPRSS3 overexpression in ovarian cancer with DNA hypomethylation?
{ "contexts": [ "In an attempt to analyze more profoundly aberrant DNA hypomethylation in epithelial ovarian cancer (EOC), we applied a novel genome-based approach which includes expression profiling following pharmacologic stimulation of DNA methylation with the methyl donor S-adenosyl-l-methionine (SAM).", ...
Our data imply that TMPRSS3-A/D overexpression in EOC is probably due to hypomethylation of their control region thus indicating that TMPRSS3-A/D variants could also represent novel molecular targets for epigenetic therapy of late stages of the disease. Our results also suggest that the frequently observed upregulation...
yes
pub_med_qa40034
[ { "content": "์ƒˆ๋กœ์šด ์œ ์ „์ฒด ๊ธฐ๋ฐ˜ ์ ‘๊ทผ๋ฒ•์ด ๋‚œ์†Œ์•”์—์„œ TMPRSS3 ๊ณผ๋ฐœํ˜„๊ณผ DNA ์ €๋ฉ”ํ‹ธํ™” ์‚ฌ์ด์— ์ƒ๊ด€๊ด€๊ณ„๊ฐ€ ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์ƒํ”ผ ๋‚œ์†Œ์•”(EOC)์—์„œ ๋” ์‹ฌ๊ฐํ•œ ๋น„์ •์ƒ DNA ์ €๋ฉ”ํ‹ธํ™”๋ฅผ ๋ถ„์„ํ•˜๊ธฐ ์œ„ํ•ด, ์šฐ๋ฆฌ๋Š” ๋ฉ”ํ‹ธ ๊ณต์—ฌ์ฒด S-์•„๋ฐ๋…ธ์‹ค-l-๋ฉ”ํ‹ฐ์˜ค๋‹Œ(SAM)์„ ์‚ฌ์šฉํ•œ DNA ๋ฉ”ํ‹ธํ™”์˜ ์•ฝ๋ฆฌํ•™์  ์ž๊ทน ํ›„ ๋ฐœํ˜„ ํ”„๋กœํŒŒ์ผ๋ง์„ ํฌํ•จํ•˜๋Š” ์ƒˆ๋กœ์šด ์œ ์ „์ฒด ๊ธฐ๋ฐ˜ ์ ‘๊ทผ๋ฒ•์„ ์ ์šฉํ–ˆ์Šต๋‹ˆ๋‹ค.\n\n2)\n๋„ค ๊ฐ€์ง€ ๋‹ค๋ฅธ EOC ์„ธํฌ์ฃผ(OVCAR3, SKOV3, TOV21, TO...
Our data imply that TMPRSS3-A/D overexpression in EOC is probably due to hypomethylation of their control region thus indicating that TMPRSS3-A/D variants could also represent novel molecular targets for epigenetic therapy of late stages of the disease. Our results also suggest that the frequently observed upregulation...
์šฐ๋ฆฌ์˜ ๋ฐ์ดํ„ฐ๋Š” EOC์—์„œ TMPRSS3-A/D ๊ณผ๋ฐœํ˜„์ด ๋Œ€์กฐ ์˜์—ญ์˜ ์ €๋ฉ”ํ‹ธํ™” ๋•Œ๋ฌธ์ผ ๊ฐ€๋Šฅ์„ฑ์ด ๋†’๋‹ค๋Š” ๊ฒƒ์„ ์‹œ์‚ฌํ•˜๋ฉฐ, ์ด๋Š” TMPRSS3-A/D ๋ณ€์ด์ฒด๊ฐ€ ์งˆ๋ณ‘์˜ ๋ง๊ธฐ ํ›„์„ฑ์œ ์ „ํ•™์  ์น˜๋ฃŒ๋ฅผ ์œ„ํ•œ ์ƒˆ๋กœ์šด ๋ถ„์ž ํ‘œ์ ์ด ๋  ์ˆ˜ ์žˆ์Œ์„ ๋‚˜ํƒ€๋ƒ…๋‹ˆ๋‹ค. ์šฐ๋ฆฌ์˜ ๊ฒฐ๊ณผ๋Š” ๋˜ํ•œ ์ง„ํ–‰๋œ ์•”์—์„œ IIํ˜• ์„ธ๋ฆฐ ํ”„๋กœํ…Œ์•„์ œ ์œ ์ „์ž ๊ณ„์—ด์˜ ๋‹ค์–‘ํ•œ ๊ตฌ์„ฑ์›๋“ค์ด ์ž์ฃผ ๊ด€์ฐฐ๋˜๋Š” ์ƒํ–ฅ ์กฐ์ ˆ์ด ๋น„์ •์ƒ์ ์ธ DNA ์ €๋ฉ”ํ‹ธํ™” ๋•Œ๋ฌธ์ผ ์ˆ˜ ์žˆ์Œ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค. ๋˜ํ•œ, ์šฐ๋ฆฌ์˜ ์—ฐ๊ตฌ๋Š” ๋‹ค์–‘ํ•œ ์‹คํ—˜ ์„ธํฌ ๋ชจ๋ธ์—์„œ ์ €๋ฉ”ํ‹ธํ™”๋œ ์œ ์ „์ž๋ฅผ ์‹๋ณ„ํ•˜๋Š” ๋ฐ ์‚ฌ์šฉ๋  ์ˆ˜ ์žˆ๋Š” ์œ ๋งํ•œ ๋ฐœ๊ฒฌ ์ ‘๊ทผ๋ฒ•์„ ์†Œ๊ฐœํ•ฉ๋‹ˆ๋‹ค.
22,421,107
Is the G534E-polymorphism of the gene encoding the factor VII-activating protease a risk factor for venous thrombosis and recurrent events?
{ "contexts": [ "A single nucleotide polymorphism of the factor VII activating protease (FSAP), FSAP Marburg I (rs7080536) has been identified as a risk factor for venous thrombosis, but its clinical role has so far been controversial in part due to small cohort sizes. The aim of the present case-control study wa...
We conclude that FSAP Marburg-I genotyping may be used to determine the risk for thromboembolic disorders in patients with suspected thrombophilia and known DVT or PE.
yes
pub_med_qa40035
[ { "content": "VII ํ™œ์„ฑํ™” ๋‹จ๋ฐฑ์งˆ๋ถ„ํ•ดํšจ์†Œ ์ธ์ž๋ฅผ ์ฝ”๋”ฉํ•˜๋Š” ์œ ์ „์ž์˜ G534E ๋‹คํ˜•์„ฑ์ด ์ •๋งฅ ํ˜ˆ์ „์ฆ ๋ฐ ์žฌ๋ฐœ์„ฑ ์‚ฌ๊ฑด์˜ ์œ„ํ—˜ ์š”์ธ์ž…๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\nFactor VII ํ™œ์„ฑํ™” ๋‹จ๋ฐฑ์งˆ๋ถ„ํ•ดํšจ์†Œ(FSAP)์˜ ๋‹จ์ผ ๋‰ดํด๋ ˆ์˜คํƒ€์ด๋“œ ๋‹คํ˜•์„ฑ์ธ FSAP Marburg I(rs7080536)์ด ์ •๋งฅ ํ˜ˆ์ „์ฆ์˜ ์œ„ํ—˜ ์ธ์ž๋กœ ํ™•์ธ๋˜์—ˆ์ง€๋งŒ, ๊ทธ ์ž„์ƒ์  ์—ญํ• ์€ ๋ถ€๋ถ„์ ์œผ๋กœ ์ž‘์€ ์ฝ”ํ˜ธํŠธ ํฌ๊ธฐ ๋•Œ๋ฌธ์— ๋…ผ๋ž€์ด ๋˜์–ด ์™”์Šต๋‹ˆ๋‹ค. ๋ณธ ํ™˜์ž-๋Œ€์กฐ๊ตฐ ์—ฐ๊ตฌ์˜ ๋ชฉ์ ์€ FSAP Marburg I ๋‹คํ˜•์„ฑ(...
We conclude that FSAP Marburg-I genotyping may be used to determine the risk for thromboembolic disorders in patients with suspected thrombophilia and known DVT or PE.
์šฐ๋ฆฌ๋Š” FSAP Marburg-I ์œ ์ „์žํ˜• ๋ถ„์„์ด ์˜์‹ฌ๋˜๋Š” ํ˜ˆ์†ŒํŒ์ฆ๊ฐ€์ฆ ๋ฐ ์•Œ๋ ค์ง„ DVT ๋˜๋Š” PE ํ™˜์ž์—์„œ ํ˜ˆ์ „์ƒ‰์ „ ์žฅ์• ์˜ ์œ„ํ—˜์„ ๊ฒฐ์ •ํ•˜๋Š” ๋ฐ ์‚ฌ์šฉ๋  ์ˆ˜ ์žˆ๋‹ค๊ณ  ๊ฒฐ๋ก ์ง€์—ˆ์Šต๋‹ˆ๋‹ค.
22,420,656
Does etoposide modulate the effects of oral morphine analgesia by targeting the intestinal P-glycoprotein?
{ "contexts": [ "Opioids and anticancer compounds such as etoposide (ETP) are substrates of P-glycoprotein (P-gp), an ATP-dependent efflux pump. Chemotherapy compounds may impact on the analgesic effect of opioids such as morphine when the two drugs are co-administered. In this study, we used a mouse model to det...
It may be important to consider aspects of therapeutic design such as the administration route or scheduling of drugs in patients receiving concurrent chemotherapy and opioid therapy to avoid pharmacokinetic interactions between the two agents.
yes
pub_med_qa40036
[ { "content": "์—ํ† ํฌ์‚ฌ์ด๋“œ๋Š” ์žฅ๋‚ด P-๋‹น๋‹จ๋ฐฑ์งˆ์„ ํ‘œ์ ์œผ๋กœ ํ•˜์—ฌ ๊ฒฝ๊ตฌ ๋ชจ๋ฅดํ•€ ์ง„ํ†ต ํšจ๊ณผ๋ฅผ ์กฐ์ ˆํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์˜คํ”ผ์˜ค์ด๋“œ์™€ ์—ํ† ํฌ์‚ฌ์ด๋“œ(ETP)์™€ ๊ฐ™์€ ํ•ญ์•” ํ™”ํ•ฉ๋ฌผ์€ ATP ์˜์กด์„ฑ ์œ ์ถœ ํŽŒํ”„์ธ P-๋‹น๋‹จ๋ฐฑ์งˆ(P-gp)์˜ ๊ธฐ์งˆ์ž…๋‹ˆ๋‹ค. ํ™”ํ•™ ์š”๋ฒ• ํ™”ํ•ฉ๋ฌผ์€ ๋‘ ์•ฝ๋ฌผ์„ ๋ณ‘์šฉ ํˆฌ์—ฌํ•  ๋•Œ ๋ชจ๋ฅดํ•€๊ณผ ๊ฐ™์€ ์˜คํ”ผ์˜ค์ด๋“œ์˜ ์ง„ํ†ต ํšจ๊ณผ์— ์˜ํ–ฅ์„ ๋ฏธ์น  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ์—์„œ๋Š” ๋งˆ์šฐ์Šค ๋ชจ๋ธ์„ ์‚ฌ์šฉํ•˜์—ฌ ์žฅ P-gp์˜ ๊ด€์—ฌ์— ์ดˆ์ ์„ ๋งž์ถฐ ETP์™€ ๋ชจ๋ฅดํ•€ ์‚ฌ์ด์— ์•ฝ๋ฆฌํ•™์  ์ƒํ˜ธ์ž‘์šฉ์ด ์žˆ...
It may be important to consider aspects of therapeutic design such as the administration route or scheduling of drugs in patients receiving concurrent chemotherapy and opioid therapy to avoid pharmacokinetic interactions between the two agents.
๋‘ ์•ฝ์ œ ๊ฐ„์˜ ์•ฝ๋™ํ•™์  ์ƒํ˜ธ์ž‘์šฉ์„ ํ”ผํ•˜๊ธฐ ์œ„ํ•ด ํ™”ํ•™์š”๋ฒ•๊ณผ ์˜คํ”ผ์˜ค์ด๋“œ ์š”๋ฒ•์„ ๋™์‹œ์— ๋ฐ›๋Š” ํ™˜์ž์˜ ์•ฝ๋ฌผ ํˆฌ์—ฌ ๊ฒฝ๋กœ๋‚˜ ์ผ์ •๊ณผ ๊ฐ™์€ ์น˜๋ฃŒ ์„ค๊ณ„ ์ธก๋ฉด์„ ๊ณ ๋ คํ•˜๋Š” ๊ฒƒ์ด ์ค‘์š”ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
22,432,754
Is serum phosphate measured at 6 and 12 months after successful kidney transplant independently associated with subsequent graft loss?
{ "contexts": [ "Serum phosphate concentrations have been shown to predict graft loss in prevalent, but not incident, kidney transplant populations. The reasons for this are unknown. We investigated whether serum phosphate at 6 or 12 months posttransplant was associated with graft loss in the same cohort.", "...
Serum phosphate at 6 and 12 months posttransplant is an independent predictor of graft loss. Any future trial designed to investigate the benefits of phosphate lowering should consider recruiting patients as early as 6 months posttransplant.
yes
pub_med_qa40037
[ { "content": "์„ฑ๊ณต์ ์ธ ์‹ ์žฅ ์ด์‹ ํ›„ 6๊ฐœ์›”๊ณผ 12๊ฐœ์›”์— ํ˜ˆ์ฒญ ์ธ์‚ฐ์—ผ์ด ๋…๋ฆฝ์ ์œผ๋กœ ์ธก์ •๋˜๋ฉด ์ดํ›„ ์ด์‹ํŽธ ์†์‹ค๊ณผ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\nํ˜ˆ์ฒญ ์ธ์‚ฐ์—ผ ๋†๋„๋Š” ์ผ๋ฐ˜์ ์ด์ง€๋งŒ ๋ฐœ์ƒํ•˜์ง€ ์•Š๋Š” ์‹ ์žฅ ์ด์‹ ์ง‘๋‹จ์—์„œ ์ด์‹ํŽธ ์†์‹ค์„ ์˜ˆ์ธกํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๊ทธ ์ด์œ ๋Š” ์•Œ๋ ค์ ธ ์žˆ์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ์ด์‹ ํ›„ 6๊ฐœ์›” ๋˜๋Š” 12๊ฐœ์›”์งธ์˜ ํ˜ˆ์ฒญ ์ธ์‚ฐ์—ผ์ด ๋™์ผํ•œ ์ฝ”ํ˜ธํŠธ์—์„œ ์ด์‹ํŽธ ์†์‹ค๊ณผ ๊ด€๋ จ์ด ์žˆ๋Š”์ง€ ์กฐ์‚ฌํ–ˆ์Šต๋‹ˆ๋‹ค.\n\n2)\n325๋ช…์˜ ํ™˜์ž๋ฅผ ๋Œ€์ƒ์œผ๋กœ ๋ฐ์ดํ„ฐ๋ฅผ ์ˆ˜์ง‘ํ•˜์—ฌ ๋‹จ์ผ ์„ผํ„ฐ...
Serum phosphate at 6 and 12 months posttransplant is an independent predictor of graft loss. Any future trial designed to investigate the benefits of phosphate lowering should consider recruiting patients as early as 6 months posttransplant.
์ด์‹ ํ›„ 6๊ฐœ์›” ๋ฐ 12๊ฐœ์›”์งธ์˜ ํ˜ˆ์ฒญ ์ธ์‚ฐ์—ผ์€ ์ด์‹ํŽธ ์†์‹ค์˜ ๋…๋ฆฝ์ ์ธ ์˜ˆ์ธก ์ธ์ž์ž…๋‹ˆ๋‹ค. ์ธ์‚ฐ์—ผ ๊ฐ์†Œ์˜ ์ด์ ์„ ์กฐ์‚ฌํ•˜๊ธฐ ์œ„ํ•ด ์„ค๊ณ„๋œ ํ–ฅํ›„ ์ž„์ƒ์‹œํ—˜์—์„œ๋Š” ์ด์‹ ํ›„ 6๊ฐœ์›” ์ด๋‚ด์— ํ™˜์ž๋ฅผ ๋ชจ์ง‘ํ•˜๋Š” ๊ฒƒ์„ ๊ณ ๋ คํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค.
22,429,326
Do dNMT ( DNA methyltransferase ) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity?
{ "contexts": [ "Histone modifications and DNA methylation are two major factors in epigenetic phenomenon. Unlike the histone deacetylase inhibitors, which are known to exert radiosensitizing effects, there have only been a few studies thus far concerning the role of DNA methyltransferase (DNMT) inhibitors as rad...
Psammaplin A, 5-aza-2'-deoxycytidine, and zebularine induce radiosensitivity in both A549 and U373MG cell lines, and suggest that this effect might be associated with the inhibition of DNA repair.
yes
pub_med_qa40038
[ { "content": "dNMT(DNA ๋ฉ”ํ‹ธํŠธ๋žœ์Šคํผ๋ผ์ œ) ์–ต์ œ์ œ๋Š” DNA ๋ณต๊ตฌ ํ™œ๋™์„ ์–ต์ œํ•˜์—ฌ ์ธ๊ฐ„ ์•”์„ธํฌ๋ฅผ ๋ฐฉ์‚ฌ์„  ๊ฐ์ž‘์‹œํ‚ค๋‚˜์š”?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\nํžˆ์Šคํ†ค ๋ณ€ํ˜•๊ณผ DNA ๋ฉ”ํ‹ธํ™”๋Š” ํ›„์„ฑ์œ ์ „ ํ˜„์ƒ์˜ ๋‘ ๊ฐ€์ง€ ์ฃผ์š” ์š”์ธ์ž…๋‹ˆ๋‹ค. ๋ฐฉ์‚ฌ์„  ๊ฐ์ž‘ ํšจ๊ณผ๋ฅผ ๋ฐœํœ˜ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ์•Œ๋ ค์ง„ ํžˆ์Šคํ†ค ํƒˆ์•„์„ธํ‹ธํ™” ํšจ์†Œ ์–ต์ œ์ œ์™€ ๋‹ฌ๋ฆฌ, ์ง€๊ธˆ๊นŒ์ง€ ๋ฐฉ์‚ฌ์„  ๊ฐ์ž‘์ œ๋กœ์„œ DNA ๋ฉ”ํ‹ธ์ „์ดํšจ์†Œ(DNMT) ์–ต์ œ์ œ์˜ ์—ญํ• ์— ๊ด€ํ•œ ์—ฐ๊ตฌ๋Š” ๊ฑฐ์˜ ์—†์—ˆ์Šต๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ์˜ ์ฃผ์š” ๋ชฉ์ ์€ ์ธ๊ฐ„ ์•”์„ธํฌ์ฃผ์˜ ๋ฐฉ์‚ฌ์„  ๊ฐ์ž‘์— ๋Œ€ํ•œ DNMT ...
Psammaplin A, 5-aza-2'-deoxycytidine, and zebularine induce radiosensitivity in both A549 and U373MG cell lines, and suggest that this effect might be associated with the inhibition of DNA repair.
ํ”„์‚ฌ๋งˆํ”Œ๋ฆฐ A, 5-์•„์ž-2'-๋ฐ์˜ฅ์‹œ์‹œํ‹ฐ๋”˜, ์ œ๋ถˆ๋ผ๋ฆฐ์€ A549 ๋ฐ U373MG ์„ธํฌ์ฃผ ๋ชจ๋‘์—์„œ ๋ฐฉ์‚ฌ์„  ๋ฏผ๊ฐ์„ฑ์„ ์œ ๋ฐœํ•˜๋ฉฐ, ์ด ํšจ๊ณผ๊ฐ€ DNA ๋ณต๊ตฌ ์–ต์ œ์™€ ๊ด€๋ จ์ด ์žˆ์„ ์ˆ˜ ์žˆ์Œ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
22,425,694
Do intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis?
{ "contexts": [ "Low 25-hydroxyvitamin D (25D), increased levels of fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and alkaline phosphatase (ALP) were reported to be risk factors for mortality in chronic kidney disease (CKD). However, the independent associations of these factors with cardiovascu...
Intact FGF23 levels in predialysis CKD predicted incident cardiovascular events requiring hospitalization before starting dialysis, but did not predict events during the entire follow-up period, including post dialysis initiation.
yes
pub_med_qa40039
[ { "content": "์˜จ์ „ํ•œ ์„ฌ์œ ์•„์„ธํฌ ์„ฑ์žฅ ์ธ์ž 23 ์ˆ˜์น˜๊ฐ€ ํˆฌ์„ ์‹œ์ž‘ ์ „์—๋Š” ์‹ฌํ˜ˆ๊ด€ ์‚ฌ๊ฑด์„ ์˜ˆ์ธกํ•˜์ง€๋งŒ, ํˆฌ์„ ์‹œ์ž‘ ํ›„์—๋Š” ์˜ˆ์ธกํ•˜์ง€ ๋ชปํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์˜จ์ „ํ•œ ์„ฌ์œ ์•„์„ธํฌ ์„ฑ์žฅ ์ธ์ž 23 ์ˆ˜์น˜๊ฐ€ ํˆฌ์„ ์‹œ์ž‘ ์ „์—๋Š” ์‹ฌํ˜ˆ๊ด€ ์‚ฌ๊ฑด์„ ์˜ˆ์ธกํ•˜์ง€๋งŒ, ํˆฌ์„ ์‹œ์ž‘ ํ›„์—๋Š” ์˜ˆ์ธกํ•˜์ง€ ๋ชปํ•ฉ๋‹ˆ๊นŒ?", "role": "passage" } ]
Intact FGF23 levels in predialysis CKD predicted incident cardiovascular events requiring hospitalization before starting dialysis, but did not predict events during the entire follow-up period, including post dialysis initiation.
ํˆฌ์„ ์ „ ๋งŒ์„ฑ ์‹ ์žฅ ์งˆํ™˜(CKD)์˜ ์˜จ์ „ํ•œ FGF23 ์ˆ˜์น˜๋Š” ํˆฌ์„์„ ์‹œ์ž‘ํ•˜๊ธฐ ์ „์— ์ž…์›์ด ํ•„์š”ํ•œ ์‹ฌํ˜ˆ๊ด€ ์‚ฌ๊ฑด์„ ์˜ˆ์ธกํ–ˆ์ง€๋งŒ, ํˆฌ์„ ์‹œ์ž‘ ํ›„๋ฅผ ํฌํ•จํ•œ ์ „์ฒด ์ถ”์  ๊ด€์ฐฐ ๊ธฐ๊ฐ„ ๋™์•ˆ์˜ ์‚ฌ๊ฑด์€ ์˜ˆ์ธกํ•˜์ง€ ๋ชปํ–ˆ์Šต๋‹ˆ๋‹ค.
22,426,806
Are structural and functional changes of carotid wall properties in patients with acromegaly restored after 1 year of GH/IGF1 normalization?
{ "contexts": [ "Vascular changes are common in acromegaly (ACM). Current therapies can normalise the levels of both growth hormone (GH) and insulin-like growth factor (IGF1).", "To establish whether the ACM vascular changes in patients with effectively managed disease are different from those in patients wit...
Both the controlled and active ACM patients showed structural arterial changes. After 1 year of disease control, the patients with controlled ACM showed improvements in the functional, but not the structural, arterial parameters compared with the patients with an active condition.
no
pub_med_qa40040
[ { "content": "๋ง๋‹จ๋น„๋Œ€์ฆ ํ™˜์ž์˜ ๊ฒฝ๋™๋งฅ ๋ฒฝ ํŠน์„ฑ์˜ ๊ตฌ์กฐ์  ๋ฐ ๊ธฐ๋Šฅ์  ๋ณ€ํ™”๊ฐ€ GH/IGF1 ์ •์ƒํ™” 1๋…„ ํ›„์— ํšŒ๋ณต๋ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "๋ง๋‹จ๋น„๋Œ€์ฆ ํ™˜์ž์˜ ๊ฒฝ๋™๋งฅ ๋ฒฝ ํŠน์„ฑ์˜ ๊ตฌ์กฐ์  ๋ฐ ๊ธฐ๋Šฅ์  ๋ณ€ํ™”๊ฐ€ GH/IGF1 ์ •์ƒํ™” 1๋…„ ํ›„์— ํšŒ๋ณต๋ฉ๋‹ˆ๊นŒ?", "role": "passage" } ]
Both the controlled and active ACM patients showed structural arterial changes. After 1 year of disease control, the patients with controlled ACM showed improvements in the functional, but not the structural, arterial parameters compared with the patients with an active condition.
ํ†ต์ œ๋œ ACM ํ™˜์ž์™€ ํ™œ๋™์„ฑ ACM ํ™˜์ž ๋ชจ๋‘ ๊ตฌ์กฐ์  ๋™๋งฅ ๋ณ€ํ™”๋ฅผ ๋ณด์˜€์Šต๋‹ˆ๋‹ค. 1๋…„๊ฐ„์˜ ์งˆ๋ณ‘ ํ†ต์ œ ํ›„, ํ†ต์ œ๋œ ACM ํ™˜์ž๋Š” ํ™œ๋™์„ฑ ์งˆํ™˜ ํ™˜์ž์— ๋น„ํ•ด ๊ธฐ๋Šฅ์  ๋™๋งฅ ๋งค๊ฐœ๋ณ€์ˆ˜๋Š” ๊ฐœ์„ ๋˜์—ˆ์ง€๋งŒ ๊ตฌ์กฐ์  ๋™๋งฅ ๋งค๊ฐœ๋ณ€์ˆ˜๋Š” ๊ฐœ์„ ๋˜์ง€ ์•Š์•˜์Šต๋‹ˆ๋‹ค.
22,445,991
Does [ Slow-release recombinant human bone morphogenetic protein-2 suppress chromium wear particle-induced osteolysis in rats ]?
{ "contexts": [ "To observe the effect of a slow-release recombinant human bone morphogenetic protein-2 (rhBMP-2) formulation on the expressions of receptor activator of nuclear factor-ฮบB ligand (RANKL) and osteoprotegerin (OPG) in a murine air pouch model of bone implantation.", "A cranial bone allograft was...
Chromium particles can cause osteolysis by increasing the RANKL/OPG ratio in rats, and intervention with slow-release rhBMP-2 can significantly promote bone formation and suppress bone resorption by decreasing RANKL/OPG ratio.
yes
pub_med_qa40041
[ { "content": "[๋А๋ฆฐ ๋ฐฉ์ถœ ์žฌ์กฐํ•ฉ ์ธ๊ฐ„ ๋ผˆ ํ˜•ํƒœํ˜•์„ฑ ๋‹จ๋ฐฑ์งˆ-2๊ฐ€ ์ฅ์˜ ํฌ๋กฌ ๋งˆ๋ชจ ์ž…์ž ์œ ๋ฐœ ๊ณจ๋ถ„ํ•ด๋ฅผ ์–ต์ œํ•ฉ๋‹ˆ๊นŒ?]?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๋А๋ฆฐ ๋ฐฉ์ถœ ์žฌ์กฐํ•ฉ ์ธ๊ฐ„ ๋ผˆ ํ˜•ํƒœํ˜•์„ฑ ๋‹จ๋ฐฑ์งˆ-2(rhBMP-2) ์ œํ˜•์ด ๋ผˆ ์ด์‹์˜ ์ฅ ๊ณต๊ธฐ ์ฃผ๋จธ๋‹ˆ ๋ชจ๋ธ์—์„œ ํ•ต ์ธ์ž-B ๋ฆฌ๊ฐ„๋“œ(RANKL) ๋ฐ ๊ณจ๋‹จ๋ฐฑ(OPG) ์ˆ˜์šฉ์ฒด ํ™œ์„ฑํ™”์ œ ๋ฐœํ˜„์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์„ ๊ด€์ฐฐํ•ฉ๋‹ˆ๋‹ค.\n\n2)\n์ˆ˜ํ˜œ์ž์˜ ๋“ฑ์— ์œ ๋„๋œ ์—์–ด ํŒŒ์šฐ์น˜์— ๋‘๊ฐœ๊ณจ ๋™์ข… ์ด์‹ํŽธ์„ ์ด์‹ํ–ˆ์Šต๋‹ˆ๋‹ค. ๊ทธ๋Ÿฐ ๋‹ค์Œ ์ฅ ๋ชจ๋ธ์„ 5๊ฐœ ๊ทธ๋ฃน์œผ๋กœ ๋ฌด์ž‘์œ„...
Chromium particles can cause osteolysis by increasing the RANKL/OPG ratio in rats, and intervention with slow-release rhBMP-2 can significantly promote bone formation and suppress bone resorption by decreasing RANKL/OPG ratio.
ํฌ๋กฌ ์ž…์ž๋Š” ์ฅ์˜ RANKL/OPG ๋น„์œจ์„ ์ฆ๊ฐ€์‹œ์ผœ ๊ณจ ์šฉํ•ด๋ฅผ ์ผ์œผํ‚ฌ ์ˆ˜ ์žˆ์œผ๋ฉฐ, ์ฒœ์ฒœํžˆ ๋ฐฉ์ถœ๋˜๋Š” rhBMP-2๋ฅผ ์‚ฌ์šฉํ•˜๋ฉด RANKL/OPG ๋น„์œจ์„ ๊ฐ์†Œ์‹œ์ผœ ๋ผˆ ํ˜•์„ฑ์„ ํฌ๊ฒŒ ์ด‰์ง„ํ•˜๊ณ  ๋ผˆ ํก์ˆ˜๋ฅผ ์–ต์ œํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
22,445,867
Does early adrenaline administration improve circulatory recovery during resuscitation from severe asphyxia in newborn piglets?
{ "contexts": [ "To investigate the effects of early intravenous adrenaline administration on circulatory recovery, cerebral reoxygenation, and plasma catecholamine concentrations, after severe asphyxia-induced bradycardia and hypotension.", "One-day-old piglets were left in apnoea until heart rate and mean a...
The high endogenous catecholamine levels, especially those of noradrenaline, may explain why early administered adrenaline did not significantly improve resuscitation outcome.
no
pub_med_qa40042
[ { "content": "์ดˆ๊ธฐ ์•„๋“œ๋ ˆ๋‚ ๋ฆฐ ํˆฌ์—ฌ๊ฐ€ ์‹ ์ƒ์•„ ๋ผ์ง€์˜ ์ค‘์ฆ ์งˆ์‹์—์„œ ์†Œ์ƒํ•˜๋Š” ๋™์•ˆ ์ˆœํ™˜ ํšŒ๋ณต์„ ๊ฐœ์„ ํ•ฉ๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ดˆ๊ธฐ ์•„๋“œ๋ ˆ๋‚ ๋ฆฐ ํˆฌ์—ฌ๊ฐ€ ์‹ ์ƒ์•„ ๋ผ์ง€์˜ ์ค‘์ฆ ์งˆ์‹์—์„œ ์†Œ์ƒํ•˜๋Š” ๋™์•ˆ ์ˆœํ™˜ ํšŒ๋ณต์„ ๊ฐœ์„ ํ•ฉ๋‹ˆ๊นŒ?", "role": "passage" } ]
The high endogenous catecholamine levels, especially those of noradrenaline, may explain why early administered adrenaline did not significantly improve resuscitation outcome.
๋†’์€ ๋‚ด์ธ์„ฑ ์นดํ…Œ์ฝœ์•„๋ฏผ ์ˆ˜์น˜, ํŠนํžˆ ๋…ธ๋ฅด์•„๋“œ๋ ˆ๋‚ ๋ฆฐ ์ˆ˜์น˜๋Š” ์กฐ๊ธฐ ํˆฌ์—ฌ๋œ ์•„๋“œ๋ ˆ๋‚ ๋ฆฐ์ด ์†Œ์ƒ์ˆ  ๊ฒฐ๊ณผ๋ฅผ ํฌ๊ฒŒ ๊ฐœ์„ ํ•˜์ง€ ๋ชปํ•œ ์ด์œ ๋ฅผ ์„ค๋ช…ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
19,061,742
Is type of hip fracture in patients with Parkinson disease associated with femoral bone mineral density?
{ "contexts": [ "To investigate the association between bone mineral density (BMD) and hip fracture type (cervical or trochanteric) in a sample of fallers with Parkinson disease (PD).", "Observational study.", "Rehabilitation hospital in Italy.", "We investigated 1040 of 1120 white fallers consecutive...
In a sample of PD fallers as in a control group of non-PD fallers, BMD levels assessed at 3 femoral sites were significantly lower in the patients who sustained trochanteric fractures than in those with cervical fractures of the hip.
yes
pub_med_qa40043
[ { "content": "ํŒŒํ‚จ์Šจ๋ณ‘ ํ™˜์ž์˜ ๊ณ ๊ด€์ ˆ ๊ณจ์ ˆ ์œ ํ˜•์ด ๋Œ€ํ‡ด๊ณจ ๊ณจ๋ฐ€๋„์™€ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๊นŒ?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\nํŒŒํ‚จ์Šจ๋ณ‘(PD)์„ ์•“๊ณ  ์žˆ๋Š” ๋‚™์ƒ์ž ์ƒ˜ํ”Œ์—์„œ ๊ณจ๋ฐ€๋„(BMD)์™€ ๊ณ ๊ด€์ ˆ ๊ณจ์ ˆ ์œ ํ˜•(๊ฒฝ์ถ” ๋˜๋Š” ๋Œ€ํ‡ด๊ณจ ๊ณจ์ ˆ) ๊ฐ„์˜ ์—ฐ๊ด€์„ฑ์„ ์กฐ์‚ฌํ•˜๊ธฐ ์œ„ํ•ด.\n\n2)\n๊ด€์ฐฐ ์—ฐ๊ตฌ.\n\n3)\n์ดํƒˆ๋ฆฌ์•„์˜ ์žฌํ™œ ๋ณ‘์›.\n\n4)\n๊ณ ๊ด€์ ˆ ๊ณจ์ ˆ๋กœ ์žฌํ™œ๋ณ‘์›์— ์—ฐ์† ์ž…์›ํ•œ ๋ฐฑ์ธ ๋‚™์ƒ์ž 1120๋ช… ์ค‘ 1040๋ช…์„ ๋Œ€์ƒ์œผ๋กœ ์กฐ์‚ฌํ–ˆ์Šต๋‹ˆ๋‹ค. 1040๋ช…์˜ ํ™˜์ž ์ค‘ 38๋ช…(3.65%)์ด 2์ฐจ์ ์œผ๋กœ P...
In a sample of PD fallers as in a control group of non-PD fallers, BMD levels assessed at 3 femoral sites were significantly lower in the patients who sustained trochanteric fractures than in those with cervical fractures of the hip.
๋น„PD ๋‚™์ƒ์ž ๋Œ€์กฐ๊ตฐ๊ณผ ๋งˆ์ฐฌ๊ฐ€์ง€๋กœ PD ๋‚™์ƒ์ž ์ƒ˜ํ”Œ์—์„œ 3๊ฐœ์˜ ๋Œ€ํ‡ด๊ณจ ๋ถ€์œ„์—์„œ ํ‰๊ฐ€๋œ BMD ์ˆ˜์น˜๋Š” ๊ณ ๊ด€์ ˆ ๊ฒฝ์ถ” ๊ณจ์ ˆ ํ™˜์ž๋ณด๋‹ค ๋Œ€ํ‡ด๊ณจ ๊ณจ์ ˆ์„ ์ž…์€ ํ™˜์ž์—์„œ ์œ ์˜ํ•˜๊ฒŒ ๋‚ฎ์•˜์Šต๋‹ˆ๋‹ค.
19,066,113
Does leptin play a role in ruptured human brain arteriovenous malformations?
{ "contexts": [ "Intracerebral hemorrhage (ICH) is one of the most common clinical manifestations of human brain arteriovenous malformation (BAVM). However, the hemorrhagic mechanism of BAVM is still unclear. Leptin, first discovered in obesity research, has not been systematically studied in BAVM and ICH. We inv...
The transcriptional and translational levels of leptin, leptin receptor, and STAT3 were higher in hemorrhagic BAVM, suggesting that leptin may play an important role in the hemorrhagic mechanism of BAVM.
yes
pub_med_qa40044
[ { "content": "๋ ™ํ‹ด์ด ํŒŒ์—ด๋œ ์ธ๊ฐ„์˜ ๋‡Œ ๋™์ •๋งฅ ๊ธฐํ˜•์— ์—ญํ• ์„ ํ•˜๋‚˜์š”?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n๋‡Œ๋‚ด ์ถœํ˜ˆ(ICH)์€ ์ธ๊ฐ„ ๋‡Œ ๋™์ •๋งฅ ๊ธฐํ˜•(BAVM)์˜ ๊ฐ€์žฅ ํ”ํ•œ ์ž„์ƒ ์ฆ์ƒ ์ค‘ ํ•˜๋‚˜์ž…๋‹ˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ BAVM์˜ ์ถœํ˜ˆ ๊ธฐ์ „์€ ์•„์ง ๋ช…ํ™•ํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ๋น„๋งŒ ์—ฐ๊ตฌ์—์„œ ์ฒ˜์Œ ๋ฐœ๊ฒฌ๋œ ๋ ™ํ‹ด์€ BAVM๊ณผ ICH์—์„œ ์ฒด๊ณ„์ ์œผ๋กœ ์—ฐ๊ตฌ๋˜์ง€ ์•Š์•˜์Šต๋‹ˆ๋‹ค. ์šฐ๋ฆฌ๋Š” ์ธ๊ฐ„ BAVM์— ๋Œ€ํ•œ ๋ ™ํ‹ด์˜ ๋ฐœํ˜„๊ณผ ํšจ๊ณผ๋ฅผ ์กฐ์‚ฌํ–ˆ์Šต๋‹ˆ๋‹ค.\n\n2)\n6๋ช…์˜ BAVM ํ™˜์ž๋กœ๋ถ€ํ„ฐ ํ‘œ๋ณธ์„ ์ฑ„์ทจํ•˜์—ฌ ์ถœํ˜ˆ์„ฑ ๋˜๋Š” ๋น„์ถœํ˜ˆ์„ฑ ๊ทธ...
The transcriptional and translational levels of leptin, leptin receptor, and STAT3 were higher in hemorrhagic BAVM, suggesting that leptin may play an important role in the hemorrhagic mechanism of BAVM.
์ถœํ˜ˆ์„ฑ BAVM์—์„œ ๋ ™ํ‹ด, ๋ ™ํ‹ด ์ˆ˜์šฉ์ฒด, STAT3์˜ ์ „์‚ฌ ๋ฐ ๋ฒˆ์—ญ ์ˆ˜์ค€์ด ๋” ๋†’์•˜์œผ๋ฉฐ, ์ด๋Š” ๋ ™ํ‹ด์ด BAVM์˜ ์ถœํ˜ˆ ๋ฉ”์ปค๋‹ˆ์ฆ˜์—์„œ ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•  ์ˆ˜ ์žˆ์Œ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
19,073,629
Does a transient outward potassium current activator recapitulate the electrocardiographic manifestations of Brugada syndrome?
{ "contexts": [ "Transient outward potassium current (I(to)) is thought to be central to the pathogenesis of the Brugada syndrome (BrS). However, an I((to)) activator has not been available with which to validate this hypothesis. Here, we provide a direct test of the hypothesis using a novel I(to) activator, NS58...
The I(to) activator NS5806 recapitulates the electrographic and arrhythmic manifestation of BrS, providing evidence in support of its pivotal role in the genesis of the disease. Our findings also suggest that a genetic defect leading to a gain of function of I(to) could explain variants of BrS, in which ST-segment elev...
yes
pub_med_qa40045
[ { "content": "์ผ์‹œ์ ์ธ ์™ธ๋ถ€ ์นผ๋ฅจ ์ „๋ฅ˜ ํ™œ์„ฑ์ œ๊ฐ€ ๋ธŒ๋ฃจ๊ฐ€๋‹ค ์ฆํ›„๊ตฐ์˜ ์‹ฌ์ „๋„ ์ฆ์ƒ์„ ์š”์•ฝํ•˜๋‚˜์š”?", "role": "user" }, { "content": "์ผ์‹œ์ ์ธ ์™ธ๋ถ€ ์นผ๋ฅจ ์ „๋ฅ˜ ํ™œ์„ฑ์ œ๊ฐ€ ๋ธŒ๋ฃจ๊ฐ€๋‹ค ์ฆํ›„๊ตฐ์˜ ์‹ฌ์ „๋„ ์ฆ์ƒ์„ ์š”์•ฝํ•˜๋‚˜์š”?", "role": "passage" } ]
The I(to) activator NS5806 recapitulates the electrographic and arrhythmic manifestation of BrS, providing evidence in support of its pivotal role in the genesis of the disease. Our findings also suggest that a genetic defect leading to a gain of function of I(to) could explain variants of BrS, in which ST-segment elev...
I(to) ํ™œ์„ฑํ™”์ œ NS5806์€ BRS์˜ ์ „๊ธฐ์  ๋ฐ ๋ถ€์ •๋งฅ์  ๋ฐœํ˜„์„ ์š”์•ฝํ•˜์—ฌ ์งˆ๋ณ‘์˜ ๋ฐœ๋ณ‘์— ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•œ๋‹ค๋Š” ์ฆ๊ฑฐ๋ฅผ ์ œ๊ณตํ•ฉ๋‹ˆ๋‹ค. ์šฐ๋ฆฌ์˜ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” ๋˜ํ•œ I(to)์˜ ๊ธฐ๋Šฅ ํ–ฅ์ƒ์„ ์ดˆ๋ž˜ํ•˜๋Š” ์œ ์ „์  ๊ฒฐํ•จ์ด ์˜ค๋ฅธ์ชฝ ๋ฐ ์™ผ์ชฝ ์‹ฌ์ „๋„ ๋ฆฌ๋“œ ๋ชจ๋‘์—์„œ ST-์„ธ๊ทธ๋จผํŠธ ์ƒ์Šน ๋˜๋Š” J-ํŒŒ๊ฐ€ ๋šœ๋ ทํ•˜๊ฒŒ ๋‚˜ํƒ€๋‚˜๋Š” BRS์˜ ๋ณ€์ด๋ฅผ ์„ค๋ช…ํ•  ์ˆ˜ ์žˆ์Œ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
19,070,354
Does novel recombinant fibrinogenase of Agkistrodon acutus venom protect against LPS-induced DIC?
{ "contexts": [ "Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by the widespread activation of coagulation. This leads to failure of multiple organs in the body and finally death. Because there is no effective therapy for DIC, the clinical prognosis is poor and the mortality i...
Our findings suggest that rFII from Agkistrodon acutus venom could have protective effect on DIC via reducing liver and renal damages and direct degradation of microthrombi.
yes
pub_med_qa40046
[ { "content": "์•„๊ทธํ‚ค์ŠคํŠธ๋กœ๋ˆ ์•„ํํˆฌ์Šค ๋…์˜ ์ƒˆ๋กœ์šด ์žฌ์กฐํ•ฉ ํ”ผ๋ธŒ๋ฆฌ๋…ธ๊ฒŒ๋‚˜์ œ๊ฐ€ LPS๋กœ ์œ ๋ฐœ๋œ DIC๋กœ๋ถ€ํ„ฐ ๋ณดํ˜ธํ•˜๋‚˜์š”?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\nํŒŒ์ข…์„ฑ ํ˜ˆ๊ด€ ๋‚ด ์‘๊ณ (DIC)๋Š” ์‘๊ณ ์˜ ๊ด‘๋ฒ”์œ„ํ•œ ํ™œ์„ฑํ™”๋ฅผ ํŠน์ง•์œผ๋กœ ํ•˜๋Š” ํ›„์ฒœ์„ฑ ์ฆํ›„๊ตฐ์ž…๋‹ˆ๋‹ค. ์ด๋กœ ์ธํ•ด ์‹ ์ฒด์˜ ์—ฌ๋Ÿฌ ์žฅ๊ธฐ๊ฐ€ ์‹คํŒจํ•˜๊ณ  ๊ฒฐ๊ตญ ์‚ฌ๋ง์— ์ด๋ฅด๊ฒŒ ๋ฉ๋‹ˆ๋‹ค. DIC์— ๋Œ€ํ•œ ํšจ๊ณผ์ ์ธ ์น˜๋ฃŒ๋ฒ•์ด ์—†๊ธฐ ๋•Œ๋ฌธ์— ์ž„์ƒ ์˜ˆํ›„๊ฐ€ ์ข‹์ง€ ์•Š๊ณ  ์‚ฌ๋ง๋ฅ ์ด ๋†’์Šต๋‹ˆ๋‹ค.\n\n2)\n๋™๋ฌผ์—๊ฒŒ 6์‹œ๊ฐ„ ๋™์•ˆ ๋ฆฌํฌ๋‹ค๋‹น๋ฅ˜(LPS)๋ฅผ ์ •๋งฅ ์ฃผ์‚ฌํ•˜๊ณ  2์‹œ๊ฐ„ ๋™์•ˆ 3ํšŒ...
Our findings suggest that rFII from Agkistrodon acutus venom could have protective effect on DIC via reducing liver and renal damages and direct degradation of microthrombi.
์šฐ๋ฆฌ์˜ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ์— ๋”ฐ๋ฅด๋ฉด ์•„๊ทธํ‚ค์ŠคํŠธ๋กœ๋ˆ ์•„ํํˆฌ์Šค ๋…์˜ rFII๋Š” ๊ฐ„๊ณผ ์‹ ์žฅ ์†์ƒ์„ ์ค„์ด๊ณ  ๋ฏธ์„ธํ˜ˆ์ „์ฆ์„ ์ง์ ‘์ ์œผ๋กœ ์•…ํ™”์‹œํ‚ด์œผ๋กœ์จ DIC์— ๋Œ€ํ•œ ๋ณดํ˜ธ ํšจ๊ณผ๋ฅผ ๊ฐ€์งˆ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
19,058,099
Does a note on the use of passive alcohol sensors during routine traffic stop?
{ "contexts": [ "To determine whether the use of a passive alcohol sensor (PAS) in routine traffic enforcement increases the driving-under-the-influence (DUI) arrest rate of alcohol-impaired drivers.", "Officers in a Maryland police department were randomly assigned to one of two groups: the first with PAS de...
The PAS appears to increase the DUI arrest rate of officers who rarely make DUI arrests, but it does not increase the DUI arrest rate of officers who normally make DUI arrests without passive sensors. It appears that it could be successful in increasing the overall number of DUI arrests for a police department if issue...
yes
pub_med_qa40047
[ { "content": "์ผ์ƒ์ ์ธ ๊ตํ†ต ์ƒํ™ฉ์—์„œ ์ˆ˜๋™ ์•Œ์ฝ”์˜ฌ ์„ผ์„œ ์‚ฌ์šฉ์— ๋Œ€ํ•œ ๋ฉ”๋ชจ๊ฐ€ ๋ฉˆ์ถ”๋‚˜์š”?", "role": "user" }, { "content": "์ฐธ์กฐ:\n1)\n์ผ์ƒ์ ์ธ ๊ตํ†ต ๋‹จ์†์—์„œ ์ˆ˜๋™ ์•Œ์ฝ”์˜ฌ ์„ผ์„œ(PAS)๋ฅผ ์‚ฌ์šฉํ•˜๋ฉด ์•Œ์ฝ”์˜ฌ ์žฅ์•  ์šด์ „์ž์˜ ์Œ์ฃผ ์šด์ „(DUI) ์ฒดํฌ์œจ์ด ์ฆ๊ฐ€ํ•˜๋Š”์ง€ ํ™•์ธํ•ฉ๋‹ˆ๋‹ค.\n\n2)\n๋ฉ”๋ฆด๋žœ๋“œ ๊ฒฝ์ฐฐ์„œ์˜ ๊ฒฝ์ฐฐ๊ด€๋“ค์€ ๋ฌด์ž‘์œ„๋กœ ๋‘ ๊ทธ๋ฃน ์ค‘ ํ•˜๋‚˜์— ๋ฐฐ์ •๋˜์—ˆ์Šต๋‹ˆ๋‹ค: ์ฒซ ๋ฒˆ์งธ ๊ทธ๋ฃน์€ PAS ์žฅ์น˜๊ฐ€ ์žˆ๋Š” ๊ทธ๋ฃน์ด๊ณ  ๋‘ ๋ฒˆ์งธ ๊ทธ๋ฃน์€ PAS ์žฅ์น˜๊ฐ€ ์—†๋Š” ๊ทธ๋ฃน(ํ†ต์ œ ๊ทธ๋ฃน)์ž…๋‹ˆ๋‹ค. ๊ทธ๋Ÿฐ ๋‹ค์Œ PAS ์žฅ์น˜๋Š” ์ฒซ ๋ฒˆ์งธ ๊ทธ๋ฃน...
The PAS appears to increase the DUI arrest rate of officers who rarely make DUI arrests, but it does not increase the DUI arrest rate of officers who normally make DUI arrests without passive sensors. It appears that it could be successful in increasing the overall number of DUI arrests for a police department if issue...
PAS๋Š” DUI ์ฒดํฌ๋ฅผ ๊ฑฐ์˜ ํ•˜์ง€ ์•Š๋Š” ๊ฒฝ์ฐฐ๊ด€๋“ค์˜ DUI ์ฒดํฌ์œจ์„ ๋†’์ด๋Š” ๊ฒƒ์œผ๋กœ ๋ณด์ด์ง€๋งŒ, ์ˆ˜๋™ ์„ผ์„œ ์—†์ด ์ผ๋ฐ˜์ ์œผ๋กœ DUI ์ฒดํฌ๋ฅผ ํ•˜๋Š” ๊ฒฝ์ฐฐ๊ด€๋“ค์˜ DUI ์ฒดํฌ์œจ์„ ๋†’์ด์ง€๋Š” ์•Š์Šต๋‹ˆ๋‹ค. ๊ฒฝ์ฐฐ์„œ์— ์ „์ฒด DUI ์ฒดํฌ ๊ฑด์ˆ˜๋ฅผ ๋Š˜๋ฆฌ๋Š” ๋ฐ ์„ฑ๊ณตํ•  ์ˆ˜ ์žˆ์„ ๊ฒƒ์œผ๋กœ ๋ณด์ด๋ฉฐ, ํ‰์†Œ DUI ์ฒดํฌ๋ฅผ ํ•˜์ง€ ์•Š๋Š” ์ˆœ์ฐฐ ๊ฒฝ์ฐฐ๊ด€๋“ค์—๊ฒŒ๋„ ๊ต์œก์ด ์ œ๊ณต๋  ์ˆ˜ ์žˆ์„ ๊ฒƒ์œผ๋กœ ๋ณด์ž…๋‹ˆ๋‹ค.
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