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### Question: Can 'partial' PTSD explain differences in diagnosis of PTSD by questionnaire self-report and interview after head injury? ### Context: Can the concept of 'partial' PTSD explain the disparity between the relatively high incidence of PTSD found using self-report questionnaires and the relatively low inciden... |
### Question: Does polymorphism -116C/G of human X-box-binding protein 1 promoter is associate with risk of Alzheimer 's disease? ### Context: Alzheimer's disease (AD) is a multifactor disease that has been reported to have a close association with endoplasmic reticulum (ER) stress response. In the response, the regula... |
### Question: Does the effect of discordance among violence and general recidivism risk estimate on predictive accuracy? ### Context: Previous research has shown that the prediction of short-term inpatient violence is negatively affected when clinicians' inter-rater agreement is low and when confidence in the estimate ... |
### Question: Is prostate tumour volume an independent predictor of early biochemical recurrence in a high risk radical prostatectomy subgroup? ### Context: To assess if accurately determined tumour volume variables could serve as independent predictors of early biochemical recurrence in high risk prostate cancer patie... |
### Question: Does ranitidine effectively relieve symptoms in a subset of patients with functional dyspepsia? ### Context: Acid secretion inhibitors are of dubious value to most patients with functional dyspepsia but might be effective in a subset. The aims of the trial were to compare the effect of ranitidine with tha... |
### Question: Is fetal cerebral vascular resistance affected by the presence of nuchal cord(s) in the third trimester of pregnancy? ### Context: To assess whether fetal cerebral vascular resistance is affected by the presence of nuchal cord(s) in the third trimester.A set of 115 patients with well-established dates and... |
### Question: Are psychiatric and psychosomatic symptoms increasing problems among Swedish schoolchildren? ### Context: Paediatricians and other professionals in Sweden note that the amount of children with psychiatric and psychosomatic symptoms is growing in number. Suicide attempts among the young (15-24 y) increased... |
### Question: EuroSCORE: useful in directing preoperative intra-aortic balloon pump placement in cardiac surgery? ### Context: The placement of preoperative intra-aortic balloon pumps (IABP) in high-risk patients has been described, although controversy remains regarding the appropriate selection of these patients. The... |
### Question: Does exercise intensity affect blood pressure and heart rate in obese adolescents? ### Context: Aerobic exercise improves cardiovascular health in general, but whether the impact varies with exercise intensity is not clear.The aim of the current study was to compare the effects of a high-intensity aerobic... |
### Question: Does nF-κB potentiate caspase independent hydrogen peroxide induced cell death? ### Context: The pro-survival activity of NF-κB in response to a variety of stimuli has been extensively characterized. Although there have been a few reports addressing the pro-cell death role of NF-κB, the precise mechanism ... |
### Question: Does ropivacaine attenuate endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling? ### Context: Acute lung injury (ALI) is associated with high mortality due to the lack of effective therapeutic strategies. Mechanical ventilation itself can cause ven... |
### Question: Is cholesterol , not just cardiovascular risk , important in deciding who should receive statin treatment? ### Context: Guidelines for primary prevention of cardiovascular disease (CVD) with statins, including the most recent, fail to make the best use of the evidence from clinical trials by concentrating... |
### Question: Do racial and ethnic colorectal cancer patterns affect the cost-effectiveness of colorectal cancer screening in the United States? ### Context: Colorectal cancer screening beginning at age 50 is recommended for all Americans considered at "average" risk for the development of colorectal cancer.We used 198... |
### Question: Does [ Routine written intervention asserting the advantages of multiple blood cultures increase their order rate among doctors ]? ### Context: Obtaining two or more blood culture sets is important for achieving good sensitivity and for detecting contamination. However, many doctors still only order one s... |
### Question: Is chronic gastritis with expression of inducible nitric oxide synthase associated with high expression of interleukin-6 and hypergastrinaemia? ### Context: High levels of inducible nitric oxide synthase and nitrotyrosine in Helicobacter pylori-infected gastric mucosa may contribute to development of gast... |
### Question: Does anodization increase early integration of Osstem implants in sheep femurs? ### Context: Spark discharge anodic oxidation forms a porous TiO2 film on the surface of titanium oral implants, increasing surface roughness and concentrations of calcium and phosphate ions. In this study, anodic-treated oral... |
### Question: Does seromuscular colocystoplasty lined with urothelium protect dogs from acidosis during ammonium chloride loading? ### Context: We compared the metabolism of intravesical ammonium chloride in dogs in which the bladder had been enlarged by seromuscular colocystoplasty lined with urothelium, dogs that had... |
### Question: Does hemoperfusion with an immobilized polymyxin B column reduce the blood level of neutrophil elastase? ### Context: We investigated whether direct hemoperfusion with an immobilized polymyxin B column (DHP with PMX) could reduce the blood level of neutrophil elastase.20 sepsis patients were enrolled in t... |
### Question: Does p53 dependent centrosome clustering prevent multipolar mitosis in tetraploid cells? ### Context: p53 abnormality and aneuploidy often coexist in human tumors, and tetraploidy is considered as an intermediate between normal diploidy and aneuploidy. The purpose of this study was to investigate whether ... |
### Question: Does cholesterol-enriched diet cause age-related macular degeneration-like pathology in rabbit retina? ### Context: Alzheimer's disease (AD) and age-related macular degeneration (AMD) share several pathological hallmarks including β-amyloid (Aβ) accumulation, oxidative stress, and apoptotic cell death. Th... |
### Question: Endonasal measurement of mucociliary clearance at various locations in the nose: a new diagnostic tool for nasal function? ### Context: Mucociliary clearance is one of the major functions of the nasal epithelium. Limited information on the physiology or malfunction could up to now only be obtained by expe... |
### Question: Is sirolimus-based regimen associated with decreased expression of glomerular vascular endothelial growth factor? ### Context: Sirolimus (SRL) is a potent immunosuppressant used in organ transplantation. It is known to decrease vascular endothelial growth factor (VEGF) synthesis, making it an interesting ... |
### Question: Are malnutrition and inflammation associated with impaired pulmonary function in patients with chronic kidney disease? ### Context: Inflammation and malnutrition are common findings in patients with chronic kidney disease (CKD). We hypothesized that in inflamed and malnourished patients, respiratory and p... |
### Question: Does riproximin modulate multiple signaling cascades leading to cytostatic and apoptotic effects in human breast cancer cells? ### Context: Riproximin, a type II ribosome-inactivating protein (RIP), has shown significant cytotoxic effects in diverse types of cancer cells. To better understand its therapeu... |
### Question: Are high-end normal adrenocorticotropic hormone and cortisol levels associated with specific cardiovascular risk factors in pediatric obesity : a cross-sectional study? ### Context: The hypothalamic-pituitary-adrenal (HPA) axis, and in particular cortisol, has been reported to be involved in obesity-assoc... |
### Question: Do Asian breast cancer patients have poorer survival than their western counterparts? ### Context: The difference in breast cancer incidence and prognosis between ethnic groups seeks an explanation. We have recently shown that Swedish women are two to three times more likely to be diagnosed with breast ca... |
### Question: Does butein suppress breast cancer growth by reducing a production of intracellular reactive oxygen species? ### Context: Butein has various functions in human diseases including cancer. While anti-cancer effects of butein have been revealed, it is urgent to understand a unique role of butein against canc... |
### Question: Do microtubules contribute to the birefringence of the retinal nerve fiber layer? ### Context: The retinal nerve fiber layer (RNFL) exhibits birefringence that is due to the oriented cylindrical structure of the ganglion cell axons. Possible birefringent structures include axonal membranes, microtubules (... |
### Question: Are serine proteases HTRA1 and HTRA3 down-regulated with increasing grades of human endometrial cancer? ### Context: The high temperature requirement factor A (HTRA) family consists of serine proteases with domains homologous to those of bacterial HTRA. Four human HTRA members have been described: HTRA1-4... |
### Question: Do novel hydroxyapatite nanorods improve anti-caries efficacy of enamel infiltrants? ### Context: Enamel resin infiltrants are biomaterials able to treat enamel caries at early stages. Nevertheless, they cannot prevent further demineralization of mineral-depleted enamel. Therefore, the aim of this work wa... |
### Question: Do superior and basal segment lung cancers in the lower lobe have different lymph node metastatic pathways and prognosis? ### Context: Although the lower lobe is a large entity that occupies half of the hemithorax, all tumors located within the lower lobe have been treated uniformly regardless of tumor lo... |
### Question: Do patients undergoing physical testing report pain intensity reliably? ### Context: To determine the reliability of patient reports of pain intensity during the application of physical tests.A single examiner required participants to use the numeric pain rating scale (NPRS) to report the intensity of pai... |
### Question: Are vKORC1 and CYP2C9 genotypes predictors of warfarin-related outcomes in children? ### Context: Despite substantial evidence supporting a pharmacogenetic approach to warfarin therapy in adults, evidence on the importance of genetics in warfarin therapy in children is limited, particularly for clinical o... |
### Question: Does aKAP150 contribute to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus? ### Context: Increased contractility of arterial myocytes and enhanced vascular tone during hyperglycemia and diabetes mellitus may arise from im... |
### Question: Does volume of lymphatic metastases independently influence prognosis in colorectal cancer? ### Context: To evaluate the prognostic relevance of the volume of nodal metastatic disease in colorectal cancer patients.One hundred node-positive patients with T2 or T3 carcinoma of the colon or rectum after rout... |
### Question: Is admission hyperglycemia a reliable outcome predictor in children with severe traumatic brain injury? ### Context: To identify the relationship between admission hyperglycemia and outcome in children with severe brain injury at hospital discharge and 6 months later.A retrospective analysis of blood gluc... |
### Question: Is current evidence insufficient to define an optimal threshold for intervention in isolated type II endoleak after endovascular aneurysm repair? ### Context: To report a systematic review and meta-regression of the association between the threshold for intervention in patients with isolated type II endol... |
### Question: Does enhancement of canonical Wnt/β-catenin signaling activity by HCV core protein promote cell growth of hepatocellular carcinoma cells? ### Context: The Hepatitis C virus (HCV) core protein has been implicated as a potential oncogene or a cofactor in HCV-related hepatocellular carcinoma (HCC), but the u... |
### Question: Does stem cell therapy improve the outcome of liver resection in cirrhotics? ### Context: Significant proportions of liver cirrhotic patients develop hepatocellular carcinoma and have to undergo hepatic resection. The compromised cirrhotic liver cannot withstand further removal of hepatic tissue, thus, le... |
### Question: Are increased circulating cell signalling phosphoproteins in sera useful for the detection of pancreatic cancer? ### Context: Intracellular phosphoprotein activation significantly regulates cancer progression. However, the significance of circulating phosphoproteins in the blood remains unknown. We invest... |
### Question: Do malarial pigment haemozoin , IFN-gamma , TNF-alpha , IL-1beta and LPS stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes? ### Context: Enhanced production of nitric oxide (NO) following upmodulation of the inducible isoform of NO sy... |
### Question: Immigrant general practitioners in Norway: a special resource? ### Context: To explore whether and how immigrant general practitioners (GPs) in two major cities in Norway think that their own ethnic background affects their practices and their work.Qualitative focus group and individual interviews with se... |
### Question: Does the addition of Serenoa repens to tamsulosin improve its therapeutical efficacy in benign prostatic hyperplasia? ### Context: In this prospective study patients had to have prostate volume (PV)<50 mL, International Prostate Symptom Score (IPSS) of 7-18, Quality of Life score (QoLs)>3, a maximal flow ... |
### Question: Does the ubiquitin proteasome system function as an inhibitory constraint on synaptic strengthening? ### Context: Long-lasting forms of synaptic plasticity have been shown to depend on changes in gene expression. Although many studies have focused on the regulation of transcription and translation during ... |
### Question: Do discriminative stimuli that control instrumental tobacco-seeking by human smokers also command selective attention? ### Context: Incentive salience theory states that acquired bias in selective attention for stimuli associated with tobacco-smoke reinforcement controls the selective performance of tobac... |
### Question: Are metacarpal geometry changes during Thoroughbred race training compatible with sagittal-plane cantilever bending? ### Context: Bending of the equine metacarpal bones during locomotion is poorly understood. Cantilever bending, in particular, may influence the loading of the metacarpal bones and surround... |
### Question: Is interference of creatinine measurement in CAPD fluid dependent on glucose and creatinine concentrations? ### Context: High glucose concentration in CAPD fluid is known to interfere with creatinine measurement, which is required for assessment of peritoneal membrane permeability and adequacy of dialysis... |
### Question: Does case report to suggest an algorithm for management of total fertilisation failure prior to use of donor gametes? ### Context: Total fertilisation failure (TFF), even with intracytoplasmic sperm injection (ICSI), occurs in approximately 3 % of cycles, can be recurrent and the exact cause is difficult ... |
### Question: Is fractalkine shedding mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes? ### Context: The fractalkine (CX3CR1) ligand is expressed in astrocytes and reported to be neuroprotective. When cleaved from the membrane, soluble fractalkine (sCX3CL1) activates the rec... |
### Question: Does scorecard implementation improve identification of postpartum patients at risk for venous thromboembolism? ### Context: To evaluate if an intensive educational intervention in the use of a standardized venous thromboembolism (VTE) risk assessment tool (scorecard) improves physicians' identification a... |
### Question: Does [ Postprandial lipemia induce endothelial dysfunction and higher insulin resistance in healthy subjects ]? ### Context: To assess the effect of postprandial lipemia on endothelial function, insulin resistance, and lipid profile in healthy subjects.A prospective', interventional study in 14 healthy yo... |
### Question: Does active substance use at housing entry impair outcomes in supported housing for chronically homeless persons? ### Context: Recent clinical and policy trends have favored low-demand housing (provision of housing not contingent on alcohol and drug abstinence) in assisting chronically homeless people. Th... |
### Question: Do myofibroblasts from salivary gland adenoid cystic carcinomas promote cancer invasion by expressing MMP2 and CXCL12? ### Context: Salivary gland adenoid cystic carcinoma (ACC) is one of the most common malignant tumours in the oral and maxillofacial region, and has high aggressive potential. Tumour and ... |
### Question: Is severity of obstructive sleep apnea related to aldosterone status in subjects with resistant hypertension? ### Context: We previously described a significant correlation between plasma aldosterone concentration (PAC) and severity of obstructive sleep apnea (OSA) in patients with resistant hypertension.... |
### Question: Are glandular mast cells with distinct phenotype highly elevated in chronic rhinosinusitis with nasal polyps? ### Context: Although chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is characterized by T(H)2 inflammation, the role of mast cells is poorly understood.The objective of this study was to... |
### Question: Is atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion clinically significant? ### Context: To determine the cumulative risk of cervical intraepithelial neoplasia (CIN) 2 or 3 in patients with atypical squamous cells, cannot exclude HSIL (ASC-H).A retrospective analysis ... |
### Question: Is transoral gastroplasty safe , feasible , and induces significant weight loss in morbidly obese patients : results of the second human pilot study? ### Context: Bariatric surgical treatments have been proven to induce long-term weight loss in morbidly obese patients, but complications are relatively fre... |
### Question: Does genetic variation of γ-tocopherol methyltransferase gene contribute to elevated α-tocopherol content in soybean seeds? ### Context: Improvement of α-tocopherol content is an important breeding aim to increase the nutritional value of crops. Several efforts have been conducted to improve the α-tocophe... |
### Question: Are morphohistological features of pancreatic stump the main determinant of pancreatic fistula after pancreatoduodenectomy? ### Context: Pancreatic surgery is challenging and associated with high morbidity, mainly represented by postoperative pancreatic fistula (POPF) and its further consequences. Identif... |
### Question: Does the Sirt1 activator SRT3025 provide atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression? ### Context: The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis ... |
### Question: Are advanced glycation end-product-modified proteins of pathogenetic importance in fibromyalgia? ### Context: To quantify the serum levels of the advanced glycation end-product (AGE) pentosidine in 41 patients with fibromyalgia (FM) and 46 healthy controls. The formation of pentosidine is closely related ... |
### Question: Is trace lithium inversely associated with male suicide after adjustment of climatic factors? ### Context: Previously, we showed the inverse association between lithium in drinking water and male suicide in Kyushu Island. The narrow variation in meteorological factors of Kyushu Island and a considerable a... |
### Question: Do mucosal T-cell phenotypes in persistent atopic and nonatopic rhinitis show an association with mast cells? ### Context: Allergic rhinitis is characterized by selective expansion of T cell subsets with a CD4+ phenotype. Recently, we identified a subpopulation of nonallergic rhinitis subjects with increa... |
### Question: Does olopatadine inhibit anti-immunoglobulin E-stimulated conjunctival mast cell upregulation of ICAM-1 expression on conjunctival epithelial cells? ### Context: Olopatadine is a clinically effective dual-action (antihistamine/mast cell stabilizer) ophthalmic antiallergic agent. We have previously demonst... |
### Question: Do modest doses of beta-glucan reduce concentrations of potentially atherogenic lipoproteins? ### Context: In 1997, the US Food and Drug Administration passed a unique ruling that allowed oat bran to be registered as the first cholesterol-reducing food at a dosage of 3 g beta-glucan/d.The effects of a low... |
### Question: Do evidence suggesting that the keratinized portions of the upper and lower lid margins make complete contact during deliberate blinking? ### Context: To investigate whether the keratinized portions of the upper and lower eyelid margins make complete contact during deliberate blinking.Ten asymptomatic sub... |
### Question: Are many community hospitals undertreating breast cancer? ### Context: To compare treatment patterns and long-term outcomes between teaching and community hospitals treating patients with infiltrating ductal carcinoma (IDC).All IDCs from the Florida Cancer Data System from 1994 to 2000 were examined.Overa... |
### Question: Is small bowel obstruction in pregnancy a complex surgical problem with a high risk of fetal loss? ### Context: Small bowel obstruction (SBO) in pregnancy is rare and is most commonly caused by adhesions from previous abdominal surgery. Previous literature reviews have emphasised the need for prompt lapar... |
### Question: Does intensity of surveillance affect survival after surgery for sarcomas? ### Context: Whether current postoperative surveillance regimes result in improved overall survival (OS) of patients with extremity sarcomas is unknown.QUESTIONS/We hypothesized that a less intensive followup protocol would not be ... |
### Question: Does Anastomotic Leak Contribute to High Failure-to-rescue Rates? ### Context: Our aim was to evaluate failure-to-rescue (FTR) after anastomotic leak (AL) in colectomy patients.In the era of pay for performance, it is imperative that we understand the quality measures under which we are scrutinized. FTR h... |
### Question: Is tumor size the primary prognosticator for pancreatic cancer after regional pancreatectomy? ### Context: The purpose of this study was to evaluate the regional pancreatectomy as surgical therapy for ductal adenocarcinoma of the pancreas and to evaluate potential prognostic factors.Regional pancreatectom... |
### Question: Do insulin analogues differently activate insulin receptor isoforms and post-receptor signalling? ### Context: Five insulin analogues, with modified insulin-like molecular structures, are currently approved for treating diabetic patients. They activate cell signalling and biological responses via insulin ... |
### Question: Decline in human fertility rates with male age: a consequence of a decrease in male fecundity with aging? ### Context: The objective of this study is to investigate the influence of male age on human fertility, defined as the birth rate for a given population.Data from the Spanish National Statistics Inst... |
### Question: Is there equity in long-term healthcare utilization after traumatic brain injury? ### Context: To quantify the long-term use of various types of healthcare services in patients with traumatic brain injury and to estimate the relative contribution of predisposing characteristics, enabling factors and healt... |
### Question: Does vagal sparing surgical technique but not stoma size affect body weight loss in rodent model of gastric bypass? ### Context: The aim of this study was to evaluate whether gastric bypass with or without vagal preservation resulted in a different outcome.Body weight, food intake and postprandial peptide... |
### Question: Do lower cuff pressures improve the seal of pediatric laryngeal mask airways? ### Context: Hyperinflation of laryngeal mask airway (LMA) cuffs may be harmful because of the exertion of high pressures on pharyngeal and laryngeal structures. Although cuff manometers may be used to monitor cuff pressure, the... |
### Question: Does interventional therapy prolong the patency of hemodialysis fistulas and grafts? ### Context: To retrospectively evaluate procedural success and patency after endovascular treatment of acute dysfunctional hemodialysis fistulas and grafts in a non-preselected patient cohort.185 angiographies of hemodia... |
### Question: Isolation gowns: a false sense of security? ### Context: Isolation gowns have traditionally been used in health care situations to protect against microbial contamination. There is now concern over protection of the health care worker from contamination by patients' blood and body fluids. We quantitativel... |
### Question: Is incisional hernia rate after laparoscopic colorectal resection reduced with standardisation of specimen extraction? ### Context: Incisional hernia is a common complication of laparoscopic colorectal surgery. Extraction site may influence the rate of incisional hernias. Major risk factors for the develo... |
### Question: Does cognitive behavioral therapy in combination with systemic family therapy improve mild to moderate postpartum depression? ### Context: To explore the effect of cognitive behavioral therapy (CBT) in combination with systemic family therapy (SFT) on mild to moderate postpartum depression and sleep quali... |
### Question: Does suppression of atrogin-1 and MuRF1 prevent dexamethasone-induced atrophy of cultured myotubes? ### Context: The mechanistic role of the ubiquitin ligases atrogin-1 and MuRF1 in glucocorticoid-induced muscle wasting is not fully understood. Here, we tested the hypothesis that glucocorticoid-induced mu... |
### Question: Is endothelial cell proliferation suppressed by plasma but not serum from women with preeclampsia? ### Context: Evidence has been sought for a circulating factor derived from the placenta that suppresses endothelial cell proliferation and hence contributes to the maternal endothelial cell disturbances of ... |
### Question: Does tissue plasminogen activator attenuate ventilator-induced lung injury in rats? ### Context: To test the hypothesis that the tissue plasminogen activator (tPA) may counteract the inhibitory effect of plasminogen activator inhibitors (PAI) and attenuate lung injury in a rat model of ventilator-induced ... |
### Question: Lack of effect of norfloxacin on hyperdynamic circulation in bile duct-ligated rats despite reduction of endothelial nitric oxide synthase function: result of unchanged vascular Rho-kinase? ### Context: In cirrhosis, portal hypertension is maintained by splanchnic vasodilation owing to overproduction of t... |
### Question: Could acupuncture be an adequate alternative to dexamethasone in pediatric tonsillectomy? ### Context: Usage of nonpharmacological treatment contributes to an overall patient well-being, assisting in physical and emotional healing. Acupuncture has been reported to be useful in reducing early postoperative... |
### Question: Is non-visualization of the cavum septi pellucidi synonymous with agenesis of the corpus callosum? ### Context: To describe a cohort of fetuses with non-visualization of the cavum septi pellucidi (CSP) without callosal agenesis and to assess the significance of this finding with respect to postnatal devel... |
### Question: Telemedicine: a solution to the followup of rural trauma patients? ### Context: Outpatient followup of rural trauma patients is problematic for physicians and patients. Our hypothesis was that telemedicine-based followup of trauma patients discharged to remote areas is feasible and is associated with high... |
### Question: Do proinflammatory cytokines inhibit secretion in rat bile duct epithelium? ### Context: Cholestatic disorders often are associated with portal inflammation, but whether or how inflammation contributes to cholestasis is unknown. Thus we studied the effects of proinflammatory cytokines on bile duct epithel... |
### Question: Does thyroid function influence fracture risk? ### Context: To prospectively study the relation between TSH and risk of hip and forearm fractures.A population-based cohort study.In a substudy of the second survey of the Nord Trøndelag Health Study, Norway (HUNT2, 1995-97), linked with a hospital-based fra... |
### Question: Is recurrence of radiation enterocolitis within 1 year predictive of 5-year mortality in surgical cases of radiation enterocolitis : our 18-year experience in a single center? ### Context: Pelvic irradiation is commonly used in the treatment of pelvic malignancies. Chronic radiation enterocolitis is the m... |
### Question: Do 3-year prospective multicenter study on one-stage implant surgery and early loading in the edentulous mandible? ### Context: The long-term success rates achieved in dental implantology suggest that flexibility might well exist within the various implant systems to a degree that an altered protocol (ie,... |
### Question: Do two waves of anisotropic growth generate enlarged follicles in the spiny mouse? ### Context: Mammals exhibit a remarkable variety of phenotypes and comparative studies using novel model species are needed to uncover the evolutionary developmental mechanisms generating this diversity. Here, we undertake... |
### Question: Are multiple regimes of constrained chromosome motion regulated in the interphase Drosophila nucleus? ### Context: Increasing evidence indicates specific changes in the three-dimensional organization of chromosomes in the cell nucleus during the cell cycle and development. These changes may be linked to c... |
### Question: Do older men with higher self-rated socioeconomic status have shorter telomeres? ### Context: previous studies examining the relationship between socioeconomic status and telomere length showed conflicting results, one study finding shorter telomere length in subjects with lower socioeconomic status and o... |
### Question: Are hand abnormalities strongly associated with the duration of diabetes mellitus? ### Context: To study the prevalence of hand abnormalities in diabetic patients and to evaluate associations between the hand abnormalities and diabetic variables, ergonomic factors and smoking habits.Cross-sectional study ... |
### Question: Does swietenia macrophylla King induce mitochondrial-mediated apoptosis through p53 upregulation in HCT116 colorectal carcinoma cells? ### Context: Swietenia macrophylla King is a traditional herb used to treat various diseases including hypertension, diabetes and cancer. Previous study demonstrated its a... |
### Question: Are micromegakaryocytes specific for refractory cytopenia of childhood (RCC)? ### Context: Micromegakaryocytes (microMKs) are considered the most reliable dysplastic feature for myelodysplastic syndrome (MDS), particularly refractory cytopenia of childhood (RCC); there is no minimal threshold for the diag... |
### Question: Do cysteinyl-leukotriene levels in sputum differentiate asthma from rhinitis patients with or without bronchial hyperresponsiveness? ### Context: We have previously reported that asthma differs from rhinitis with or without bronchial hyperresponsiveness in the perception and degree of lower airway inflamm... |
### Question: Do serum sRANKL/OPG predict recurrence after radiofrequency catheter ablation of lone atrial fibrillation? ### Context: Radiofrequency catheter ablation (RFCA) is a widely accepted strategy for eliminating atrial fibrillation (AF). A considerable recurrence rate has partly been ascribed to atrial remodeli... |
### Question: Is gemtuzumab ozogamicin ( MylotargTM ) infrequently associated with sinusoidal obstructive syndrome/veno-occlusive disease? ### Context: Gemtuzumab ozogamicin (GO) is approved for the treatment of older adults with acute myeloid leukemia in first relapse. Several reports have suggested an association bet... |
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