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Daniel Negreanu: Poker | Lex Fridman Podcast #324
I don't think that we're going to be able to make this,
https://karpathy.ai/lexicap/0324-large.html#02:19:44.060
Daniel Negreanu: Poker | Lex Fridman Podcast #324
this hand work right now.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
When to fold them and when to run.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
Yeah.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
So maybe every gambler knows that the secret to surviving
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
is knowing what to throw away and knowing what to keep
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
because every hand's a winner and every hand's a loser.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
That's like a stoic philosophy.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
And the best that you can hope for is to die in your sleep.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
Every hand's a winner and every hand's a loser.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
What does that mean?
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
I like that one.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
I like, for me, that's like the difference between victim
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
and responsible, like the way that I think about it, right?
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
You can be a victim to circumstance
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
or you can be responsible for everything in your life, right?
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
So when an event happens,
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
the event itself is neither good or bad
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
until you assign it value, right?
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
So like an event happens and it can be traumatic,
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
it can be, you know, painful,
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
but you know, how you respond to it
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
is ultimately going to be up to you.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
Like you actually do have a choice.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
And that's the thing you can control.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
The fact that you, Daniel Negrano took my commentary
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
about The Gambler seriously shows once more
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
that you're a beautiful human being.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
Thank you so much for being who you are,
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
for inspiring millions of people about poker,
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
about how to live life.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
And thank you for giving me your valuable time today.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
This is amazing.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
Thanks for talking.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
It was fun, man.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
It was great to have the conversation.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
Thanks for listening to this conversation
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
with Daniel Negrano.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
To support this podcast,
https://karpathy.ai/lexicap/0324-large.html#02:21:02.420
Daniel Negreanu: Poker | Lex Fridman Podcast #324
please check out our sponsors in the description.
https://karpathy.ai/lexicap/0324-large.html#02:21:03.540
Daniel Negreanu: Poker | Lex Fridman Podcast #324
And now let me leave you with some words
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
from Doyle Brunson.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
Poker is war.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
People pretend it is a game.
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Daniel Negreanu: Poker | Lex Fridman Podcast #324
Thank you for listening and hope to see you next time.
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
turns out that if you train a planarian and then cut their heads off, the tail will regenerate a
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
brand new brain that still remembers the original information. I think planaria hold the answer to
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
pretty much every deep question of life. For one thing, they're similar to our ancestors. So they
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
have true symmetry, they have a true brain, they're not like earthworms, they're, you know,
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
they're much more advanced life form. They have lots of different internal organs, but they're
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
these little, they're about, you know, maybe two centimeters in the centimeter to two in size.
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
And they have a head and a tail. And the first thing is planaria are immortal. So they do not
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
age. There's no such thing as an old planarian. So that right there tells you that these theories
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
of thermodynamic limitations on lifespan are wrong. It's not that well over time of everything
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
degrades. No, planaria can keep it going for probably, you know, how long have they been
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
around 400 million years, right? So these are the actual, so the planaria in our lab
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
are actually in physical continuity with planaria that were here 400 million years ago.
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
The following is a conversation with Michael Levin, one of the most fascinating and brilliant
https://karpathy.ai/lexicap/0325-large.html#00:00:54.880
Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
biologists I've ever talked to. He and his lab at Tufts University works on novel ways to understand
https://karpathy.ai/lexicap/0325-large.html#00:01:00.080
Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
and control complex pattern formation in biological systems. Andre Karpathy, a world
https://karpathy.ai/lexicap/0325-large.html#00:01:07.120
Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
class AI researcher, is the person who first introduced me to Michael Levin's work. I bring
https://karpathy.ai/lexicap/0325-large.html#00:01:12.960
Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
this up because these two people make me realize that biology has a lot to teach us about AI,
https://karpathy.ai/lexicap/0325-large.html#00:01:18.880
Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
and AI might have a lot to teach us about biology. This is the Lex Friedman podcast.
https://karpathy.ai/lexicap/0325-large.html#00:01:25.680
Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
To support it, please check out our sponsors in the description. And now, dear friends,
https://karpathy.ai/lexicap/0325-large.html#00:01:32.000
Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
here's Michael Levin. Embryogenesis is the process of building the human body from a single cell. I
https://karpathy.ai/lexicap/0325-large.html#00:01:37.440
Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
think it's one of the most incredible things that exists on earth from a single embryo. So how does
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
this process work? Yeah, it is an incredible process. I think it's maybe the most magical
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
process there is. And I think one of the most fundamentally interesting things about it is that
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
it shows that each of us takes the journey from so called just physics to mind, right? Because we
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
all start life as a single quiescent, unfertilized oocyte, and it's basically a bag of chemicals,
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
and you look at that and you say, okay, this is chemistry and physics. And then nine months and
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
some years later, you have an organism with high level cognition and preferences and an inner life
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
and so on. And what embryogenesis tells us is that that transformation from physics to mind is
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
gradual. It's smooth. There is no special place where, you know, a lightning bolt says, boom,
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
now you've gone from physics to true cognition. That doesn't happen. And so we can see in this
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
process that the whole mystery, you know, the biggest mystery of the universe, basically,
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
how you get mind from matter. From just physics, in quotes. Yeah. So where's the magic into the
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
thing? How do we get from information encoded in DNA and make physical reality out of that
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
information? So one of the things that I think is really important if we're going to bring in DNA
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
into this picture is to think about the fact that what DNA encodes is the hardware of life. DNA
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
contains the instructions for the kind of micro level hardware that every cell gets to play with.
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
So all the proteins, all the signaling factors, the ion channels, all the cool little pieces of
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
hardware that cells have, that's what's in the DNA. The rest of it is in so called generic laws.
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
And these are laws of mathematics. These are laws of computation. These are laws of physics,
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
of all kinds of interesting things that are not directly in the DNA. And that process, you know,
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
I think the reason I always put just physics in quotes is because I don't think there is such a
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
thing as just physics. I think that thinking about these things in binary categories, like this is
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
physics, this is true cognition, this is as if it's only faking these kinds of things. I think
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
that's what gets us in trouble. I think that we really have to understand that it's a continuum
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
and we have to work up the scaling, the laws of scaling. And we can certainly talk about that.
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
There's a lot of really interesting thoughts to be had there.
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
So the physics is deeply integrated with the information. So the DNA doesn't exist on its own.
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
The DNA is integrated as, in some sense, in response to the laws of physics at every scale.
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
The laws of the environment it exists in.
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
Yeah, the environment and also the laws of the universe. I mean, the thing about the DNA is that
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
it's once evolution discovers a certain kind of machine, that if the physical implementation is
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
appropriate, it's sort of, and this is hard to talk about because we don't have a good vocabulary
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
for this yet, but it's a very kind of a platonic notion that if the machine is there, it pulls down
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
interesting things that you do not have to evolve from scratch because the laws of physics give it
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Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325
to you for free. So just as a really stupid example, if you're trying to evolve a particular
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