document_id int64 185 2.68k | context stringlengths 2.88k 70.8k | question stringlengths 11 194 | id int64 225 5.32k | answer stringlengths 1 933 | answer_start int64 157 69k |
|---|---|---|---|---|---|
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is the main cause of HIV-1 infection in children? | 262 | Mother-to-child transmission (MTCT) is the main cause of HIV-1 infection in children worldwide. | 370 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What plays the crucial role in the Mother to Child Transmission of HIV-1 and what increases the risk | 276 | DC-SIGNR plays a crucial role in MTCT of HIV-1 and that impaired placental DC-SIGNR expression increases risk of transmission. | 2,003 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | How many children were infected by HIV-1 in 2008-2009, worldwide? | 278 | more than 400,000 children were infected worldwide, mostly through MTCT and 90% of them lived in sub-Saharan Africa. | 2,291 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is the role of C-C Motif Chemokine Ligand 3 Like 1 (CCL3L1) in mother to child transmission of HIV-1? | 316 | High copy numbers of CCL3L1, a potent HIV-1 suppressive ligand for CCR5, are associated with higher chemokine production and lower risk of MTCT of HIV-1 among South African infants | 28,143 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is DC-GENR and where is it expressed? | 305 | Dendritic cell-specific ICAM-grabbing non-integrin-related (DC-SIGNR, also known as CD209L or liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN)) can interact with a plethora of pathogens including HIV-1 and is expressed in placental capillary endothelial cells | 3,207 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | How does the presence of DC-SIGNR affect the MTCT of HIV-1? | 306 | the presence of DC-SIGNR at the placental endothelial cell surface may protect infants from HIV-1 infection by capturing virus and promoting its degradation/presentation. | 28,910 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | Why do low levels of DC-SIGNR enhance Mother to Child Transmission of HIV-1? | 307 | in placenta containing low levels of DC-SIGNR, HIV-1 would preferentially binds CCR5 on endothelial cells resulting in a loss of placental barrier integrity and enhanced passage of maternal HIV-1-infected cells in foetal circulation leading to MTCT of HIV-1 | 29,090 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is the percentage of Mother to Child Transmission of HIV-1, when there is no intervention? | 277 | Without specific interventions, the rate of HIV-1 mother-tochild transmission (MTCT) is approximately 15-45% | 2,137 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | Does C-C chemokine receptor type 5 (CCR5) affect the transmission of HIV-1? | 312 | Genetic variants in CCR5 have been shown to influence vertical transmission of HIV-1. CCR5 promoter variants resulting in higher expression of the receptor were associated with increased risk of MTCT of HIV-1 among sub-Saharan Africans | 27,719 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | How does Mannanose Binding Lectin (MBL) affect elimination of HIV-1 pathogen? | 318 | Mannose-binding lectin (MBL) is an innate immune receptor synthesised in the liver and secreted in the bloodstream in response to inflammation signal. MBL promotes pathogen elimination by opsonization and phagocytosis, | 28,335 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | How can CCR5's effect in HIV-1 transmission be reduced? | 321 | The 32-pb deletion polymorphism in CCR5 has be shown to protect from vertical transmission of HIV-1 | 27,966 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | What is IFITM? | 568 | interferon-induced transmembrane | 353 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | How many cysteine residues are contained in the first transmembrane domain of IFITM3? | 569 | three | 701 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | What inhibits S-palmitoylation? | 570 | 2-bromopalmitic acid (2BP) | 1,509 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | What interaction is inhibited by the presence of 2-bromopalmitic acid (2BP)? | 571 | IFITM5 with FKBP11 | 1,807 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | What is a function associated with IFITM5? | 572 | bone formation factor. | 2,195 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | What regulates the antiviral activity of IFITM3? | 573 | S-palmitoylation on the protein | 3,574 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | What is another name for IFITM5? | 574 | bonerestricted IFITM-like (BRIL) protein | 6,107 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | Why is the expression of IFITM5 not promoted by interferons? | 575 | the region upstream of the ifitm5 gene lacks the interferon regulatory elements | 6,335 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | What is the amino acid similarity between IFITM5 and the other IFITM proteins? | 576 | ~ 65% similarity | 6,693 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | What is the amino acid similarity between IFITM 1, IFITM 2, and IFITM 3? | 577 | ~ 85% similarity | 6,742 |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | What amino acid might be involved in calcium binding in the C-terminal region of a protein? | 580 | aspartate | 6,817 |
1,546 | First Complete Genome Sequence of a French Bovine coronavirus Strain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477389/
SHA: eef0ecf5b8e7b179dadaef967e65f2ab68f021e1
Authors: Kin, Nathalie; Guerard, Pauline; Diancourt, Laure; Caro, Valérie; Vabret, Astrid; Ar Gouilh, Meriadeg
Date: 2017-05-25
DOI: 10.1128/genomea... | What is the size of bovine coronavirus? | 917 | 31 kb | 840 |
1,546 | First Complete Genome Sequence of a French Bovine coronavirus Strain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477389/
SHA: eef0ecf5b8e7b179dadaef967e65f2ab68f021e1
Authors: Kin, Nathalie; Guerard, Pauline; Diancourt, Laure; Caro, Valérie; Vabret, Astrid; Ar Gouilh, Meriadeg
Date: 2017-05-25
DOI: 10.1128/genomea... | What is the molecular structure of bovine coronavirus? | 918 | single-stranded, linear, and nonsegmented RNA | 784 |
1,546 | First Complete Genome Sequence of a French Bovine coronavirus Strain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477389/
SHA: eef0ecf5b8e7b179dadaef967e65f2ab68f021e1
Authors: Kin, Nathalie; Guerard, Pauline; Diancourt, Laure; Caro, Valérie; Vabret, Astrid; Ar Gouilh, Meriadeg
Date: 2017-05-25
DOI: 10.1128/genomea... | How many nucleotides does bovine coronavirus contain? | 919 | 30,847 nucleotides | 1,873 |
1,546 | First Complete Genome Sequence of a French Bovine coronavirus Strain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477389/
SHA: eef0ecf5b8e7b179dadaef967e65f2ab68f021e1
Authors: Kin, Nathalie; Guerard, Pauline; Diancourt, Laure; Caro, Valérie; Vabret, Astrid; Ar Gouilh, Meriadeg
Date: 2017-05-25
DOI: 10.1128/genomea... | What is the size of the orf1ab gene in bovine coronavirus? | 920 | 20kb | 2,034 |
1,546 | First Complete Genome Sequence of a French Bovine coronavirus Strain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477389/
SHA: eef0ecf5b8e7b179dadaef967e65f2ab68f021e1
Authors: Kin, Nathalie; Guerard, Pauline; Diancourt, Laure; Caro, Valérie; Vabret, Astrid; Ar Gouilh, Meriadeg
Date: 2017-05-25
DOI: 10.1128/genomea... | Is the orf1ab gene at the 3' or 5' end of the bovine coronavirus genome? | 921 | 5= side | 2,067 |
1,545 | Species‐specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820427/
SHA: edfe02a438fa9b667313da8f03614303fc2a4a14
Authors: Bouvier, Monique; Chen, Wei‐Ju; Arnold, John C.; Fairchok, Mary P.; Danaher, Patrick J.;... | What is a significant cause of Influenze like illness among healthy adolescents and adults presenting for medical evaluation? | 1,658 | HCoV | 5,069 |
1,545 | Species‐specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820427/
SHA: edfe02a438fa9b667313da8f03614303fc2a4a14
Authors: Bouvier, Monique; Chen, Wei‐Ju; Arnold, John C.; Fairchok, Mary P.; Danaher, Patrick J.;... | What is the most common species of Human Coronavirus among adults? | 1,659 | HCoV-OC43 | 3,997 |
1,545 | Species‐specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820427/
SHA: edfe02a438fa9b667313da8f03614303fc2a4a14
Authors: Bouvier, Monique; Chen, Wei‐Ju; Arnold, John C.; Fairchok, Mary P.; Danaher, Patrick J.;... | Which Human Coronavirus showed species specific clinical characteristics of its infection? | 1,660 | HCoV‐HKU1 | 956 |
1,545 | Species‐specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820427/
SHA: edfe02a438fa9b667313da8f03614303fc2a4a14
Authors: Bouvier, Monique; Chen, Wei‐Ju; Arnold, John C.; Fairchok, Mary P.; Danaher, Patrick J.;... | What causes the outbreak of SARS and MERS. | 1,717 | Highly virulent species of HCoV | 1,276 |
1,545 | Species‐specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820427/
SHA: edfe02a438fa9b667313da8f03614303fc2a4a14
Authors: Bouvier, Monique; Chen, Wei‐Ju; Arnold, John C.; Fairchok, Mary P.; Danaher, Patrick J.;... | What is the case fatality rate of SARS and MERS? | 1,718 | ranged from 14% to 45% | 1,448 |
1,545 | Species‐specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820427/
SHA: edfe02a438fa9b667313da8f03614303fc2a4a14
Authors: Bouvier, Monique; Chen, Wei‐Ju; Arnold, John C.; Fairchok, Mary P.; Danaher, Patrick J.;... | What were the common HCOV strains in the 5 year USA study? | 1,719 | HCoV-OC43 and HCoV-229E | 4,100 |
1,545 | Species‐specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820427/
SHA: edfe02a438fa9b667313da8f03614303fc2a4a14
Authors: Bouvier, Monique; Chen, Wei‐Ju; Arnold, John C.; Fairchok, Mary P.; Danaher, Patrick J.;... | Which species are more prevalent but less severe? | 1,720 | HCoV-HKU1, HCoV-OC43, HCoV-NL63, and HCoV-229E | 1,517 |
1,552 | One step closer to an experimental infection system for Hepatitis B Virus? --- the identification of sodium taurocholate cotransporting peptide as a viral receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562259/
SHA: f4f36a8e9fee64d59ccf22b724c7dab345102658
Authors: Chen, Pei-Jer; Wu, T-C
Date: 2013-01-11
DOI:... | What is required for a Hepatitis B infection in cells? | 2,996 | both intracellular and cell-surface factors | 1,158 |
1,552 | One step closer to an experimental infection system for Hepatitis B Virus? --- the identification of sodium taurocholate cotransporting peptide as a viral receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562259/
SHA: f4f36a8e9fee64d59ccf22b724c7dab345102658
Authors: Chen, Pei-Jer; Wu, T-C
Date: 2013-01-11
DOI:... | What regulates the broad, but less specific, virus-cell interaction in a hepatitis B infection? | 2,997 | heparan sulfates in the membrane proteins | 1,727 |
1,552 | One step closer to an experimental infection system for Hepatitis B Virus? --- the identification of sodium taurocholate cotransporting peptide as a viral receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562259/
SHA: f4f36a8e9fee64d59ccf22b724c7dab345102658
Authors: Chen, Pei-Jer; Wu, T-C
Date: 2013-01-11
DOI:... | Which protein domain of the Hepatitis B envelope is necessary for infection? | 2,998 | Nterminus of HBV preS1 (amino acids 1-47) | 2,168 |
1,552 | One step closer to an experimental infection system for Hepatitis B Virus? --- the identification of sodium taurocholate cotransporting peptide as a viral receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562259/
SHA: f4f36a8e9fee64d59ccf22b724c7dab345102658
Authors: Chen, Pei-Jer; Wu, T-C
Date: 2013-01-11
DOI:... | Where is NTCP located in the body? | 2,999 | lateral surface (canalicular) of hepatocytes | 4,322 |
1,552 | One step closer to an experimental infection system for Hepatitis B Virus? --- the identification of sodium taurocholate cotransporting peptide as a viral receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562259/
SHA: f4f36a8e9fee64d59ccf22b724c7dab345102658
Authors: Chen, Pei-Jer; Wu, T-C
Date: 2013-01-11
DOI:... | What does the NTCP protein mediate? | 3,000 | bile acid transport | 4,383 |
1,552 | One step closer to an experimental infection system for Hepatitis B Virus? --- the identification of sodium taurocholate cotransporting peptide as a viral receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562259/
SHA: f4f36a8e9fee64d59ccf22b724c7dab345102658
Authors: Chen, Pei-Jer; Wu, T-C
Date: 2013-01-11
DOI:... | Is NTCP sufficient to allow HBV infection? | 3,001 | not sufficient | 5,012 |
1,552 | One step closer to an experimental infection system for Hepatitis B Virus? --- the identification of sodium taurocholate cotransporting peptide as a viral receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562259/
SHA: f4f36a8e9fee64d59ccf22b724c7dab345102658
Authors: Chen, Pei-Jer; Wu, T-C
Date: 2013-01-11
DOI:... | Why is NTCP thought to not be sufficient for HBV infection? | 3,002 | the majority of HepaRG cells were found to express NPCT but not to be infected | 5,054 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | What kinds of viruses are Japanese encephalitis virus(JEV), tick-borne encephalitis virus(TBEV), eastern equine encephalitis virus (EEEV), sindbis virus(SV), and dengue virus(DV)? | 3,003 | arboviruses | 1,906 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | What are the current clinically-available methods to detect encephalitis viral antigens? | 3,004 | ELISA and IFA | 2,177 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | What methods exist for detecting multiple antigens simultaneously in a one-sample, laboratory test? | 3,005 | two-dimensional gel electrophoresis , protein chip, mass spectrometry, and suspension array technology | 2,474 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | How many antigens could be detected by Liew's multiplex ELISA test? | 3,006 | 9 | 2,923 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | What kind of antibodies were used in the ELISA-array assay? | 3,007 | monoclonal | 3,480 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | How was the ELISA assay validated? | 3,008 | using cultured viruses and inoculated chicken eggs with patient sera | 3,618 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | What capture antibodies were used in the study? | 3,009 | 4D5, 2B5, 1F1, 2B8, 4F9, and 4E11 | 4,365 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | What was the spotting concentration range for the capture antibodies? | 3,010 | from 0.2 to 0.0125 mg/ml | 9,091 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | How was the proper spotting concentration determined? | 3,011 | combination of minimized cross reaction and higher signal intensity | 9,317 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | How was cross reaction detection determined? | 3,012 | by applying JEV, YF, and DV cultures | 9,606 |
1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
SHA: ef2b8f83d5a3ab8ae35e4b51fea6d3ed9eb49122
Authors: Kang, Xiaoping; Li, Yuchang; Fan, Li; Lin, Fang; Wei, Jingjing; Zhu, Xiaolei; Hu, Yi; Li, Jing; Chang, Guohui; Zhu, Qingyu... | How was the ELISA-array assay validated? | 3,013 | using cultured viruses and inoculated chicken eggs with patient sera | 3,618 |
1,565 | Design, Synthesis, Evaluation and Thermodynamics of 1-Substituted Pyridylimidazo[1,5-a]Pyridine Derivatives as Cysteine Protease Inhibitors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734177/
SHA: ee8483f8f2cc5fe38be4e565eae3af9d0bb8220b
Authors: Khan, Mohd Sajid; Baig, Mohd Hassan; Ahmad, Saheem; Siddiqui, Shapi ... | What enzymes have been reported to be linked with severity of infection and various pathological conditions caused by microorganisms? | 3,041 | cysteine proteases | 2,276 |
1,565 | Design, Synthesis, Evaluation and Thermodynamics of 1-Substituted Pyridylimidazo[1,5-a]Pyridine Derivatives as Cysteine Protease Inhibitors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734177/
SHA: ee8483f8f2cc5fe38be4e565eae3af9d0bb8220b
Authors: Khan, Mohd Sajid; Baig, Mohd Hassan; Ahmad, Saheem; Siddiqui, Shapi ... | At what temperatures was the assay completed? | 3,042 | 32uC, 37uC, 42uC | 9,753 |
1,565 | Design, Synthesis, Evaluation and Thermodynamics of 1-Substituted Pyridylimidazo[1,5-a]Pyridine Derivatives as Cysteine Protease Inhibitors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734177/
SHA: ee8483f8f2cc5fe38be4e565eae3af9d0bb8220b
Authors: Khan, Mohd Sajid; Baig, Mohd Hassan; Ahmad, Saheem; Siddiqui, Shapi ... | What criteria sets the guideline for drug-like properties? | 3,043 | Lipinski's ''Rule of five'' | 6,881 |
1,565 | Design, Synthesis, Evaluation and Thermodynamics of 1-Substituted Pyridylimidazo[1,5-a]Pyridine Derivatives as Cysteine Protease Inhibitors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734177/
SHA: ee8483f8f2cc5fe38be4e565eae3af9d0bb8220b
Authors: Khan, Mohd Sajid; Baig, Mohd Hassan; Ahmad, Saheem; Siddiqui, Shapi ... | What could be novel candidates as potent inhibitors of papain like cysteine proteases in resistant microorganisms? | 3,044 | 1-substituted pyridylimidazo[1,5-a]pyridine derivatives | 22,962 |
641 | RNAi Therapeutic Platforms for Lung Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816685/
Fujita, Yu; Takeshita, Fumitaka; Kuwano, Kazuyoshi; Ochiya, Takahiro
2013-02-06
DOI:10.3390/ph6020223
License:cc-by
Abstract: RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions... | What method is useful in administering small molecules for systemic delivery to the body? | 1,612 | Intranasal | 3,238 |
641 | RNAi Therapeutic Platforms for Lung Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816685/
Fujita, Yu; Takeshita, Fumitaka; Kuwano, Kazuyoshi; Ochiya, Takahiro
2013-02-06
DOI:10.3390/ph6020223
License:cc-by
Abstract: RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions... | Why is the nasal mucosa useful in the delivery of small molecules into the body? | 1,615 | the surface area can result in rapid absorption of the medication into the blood | 3,446 |
641 | RNAi Therapeutic Platforms for Lung Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816685/
Fujita, Yu; Takeshita, Fumitaka; Kuwano, Kazuyoshi; Ochiya, Takahiro
2013-02-06
DOI:10.3390/ph6020223
License:cc-by
Abstract: RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions... | What are the most common methods of inhaled delivery of medications? | 1,616 | Metered dose inhalers (MDIs) and dry powder inhalers (DPIs) | 4,624 |
641 | RNAi Therapeutic Platforms for Lung Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816685/
Fujita, Yu; Takeshita, Fumitaka; Kuwano, Kazuyoshi; Ochiya, Takahiro
2013-02-06
DOI:10.3390/ph6020223
License:cc-by
Abstract: RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions... | What medications have shown good promise to in vivo delivery via dry powder inhalers? | 1,617 | insulin [39] and low-molecular-weight heparin [40] | 5,473 |
641 | RNAi Therapeutic Platforms for Lung Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816685/
Fujita, Yu; Takeshita, Fumitaka; Kuwano, Kazuyoshi; Ochiya, Takahiro
2013-02-06
DOI:10.3390/ph6020223
License:cc-by
Abstract: RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions... | How are siRNAs typically delivered for systemic effect? | 1,618 | intratracheal or intranasal delivery | 5,840 |
641 | RNAi Therapeutic Platforms for Lung Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816685/
Fujita, Yu; Takeshita, Fumitaka; Kuwano, Kazuyoshi; Ochiya, Takahiro
2013-02-06
DOI:10.3390/ph6020223
License:cc-by
Abstract: RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions... | What structures form the human airway? | 1,619 | respiratory bronchioles, alveolar ducts, and alveolar sacs | 6,995 |
641 | RNAi Therapeutic Platforms for Lung Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816685/
Fujita, Yu; Takeshita, Fumitaka; Kuwano, Kazuyoshi; Ochiya, Takahiro
2013-02-06
DOI:10.3390/ph6020223
License:cc-by
Abstract: RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions... | What size of particle has been shown to be most effective in the delivery to the lower airway? | 1,620 | 1-5 μm | 7,557 |
641 | RNAi Therapeutic Platforms for Lung Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816685/
Fujita, Yu; Takeshita, Fumitaka; Kuwano, Kazuyoshi; Ochiya, Takahiro
2013-02-06
DOI:10.3390/ph6020223
License:cc-by
Abstract: RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions... | What are the essential conditions in siRNA delivery to effectively produce gene silencing in the lungs? | 1,621 | delivered to their site of action, be stable, enter the target cells, and be present in the cytoplasm at sufficient concentration | 10,025 |
1,547 | Complete Genome Sequence of a Nephropathogenic Infectious Bronchitis Virus Strain Isolated in China
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795213/
SHA: f2df4fc3c60338755fd23da3d7e01c0455e20745
Authors: Yang, Jing-tian; Ma, Bing-cun
Date: 2013-10-10
DOI: 10.1128/genomea.00815-13
License: cc-by
Abstract: Infec... | How long is the SAIBK gene? | 1,622 | 27,534 nucleotides | 1,847 |
1,547 | Complete Genome Sequence of a Nephropathogenic Infectious Bronchitis Virus Strain Isolated in China
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795213/
SHA: f2df4fc3c60338755fd23da3d7e01c0455e20745
Authors: Yang, Jing-tian; Ma, Bing-cun
Date: 2013-10-10
DOI: 10.1128/genomea.00815-13
License: cc-by
Abstract: Infec... | How many open reading frames are in the SAIBK gene? | 1,623 | 10 | 1,958 |
1,547 | Complete Genome Sequence of a Nephropathogenic Infectious Bronchitis Virus Strain Isolated in China
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795213/
SHA: f2df4fc3c60338755fd23da3d7e01c0455e20745
Authors: Yang, Jing-tian; Ma, Bing-cun
Date: 2013-10-10
DOI: 10.1128/genomea.00815-13
License: cc-by
Abstract: Infec... | What virus has the closest genetic identity with the SAIBK gene? | 1,624 | Chinese IBV strain SC021202 | 2,061 |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | How many surgical masks or respirators have past studies projected will be required for a pandemic in the United States? | 257 | an estimated 7.3 billion | 6,383 |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | What is the acronym MERS-CoV? | 248 | Middle East respiratory syndrome coronavirus | 722 |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | What are the critical factors that determine the effect of an epidemic? | 249 | Transmissibility and severity | 474 |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | When did the World Health Organization (WHO) officially declare the 2019-nCoV epidemic as a Public Health Emergency of International Concern? | 250 | January 30, 2020 | 7,759 |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | What influenza virus was identified in China in 2013? | 251 | H7N9 | 5,591 |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | What past research has been done on severe, single-wave pandemics? | 252 | After a new influenza virus (H7N9) was identified in China in 2013, a series of modeling articles described the effect of, and level of preparedness for, a severe, single-wave pandemic in the United States. | 5,562 |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | What is a clinical attack rate? | 253 | the proportion of individuals who become ill with or die from a disease in a population initially uninfected | 5,816 |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | What was the clinical attack rate in the 2009 H1N1 pandemic? | 254 | 20% | 5,985 |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | What is the estimated R0 of COVID-19? | 255 | 2.2 | 7,158 |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | How many ventilators have past studies projected will be required for a pandemic in the United States? | 1,657 | 35 000 to 60 000 | 6,331 |
1,582 | Exhaled breath condensate sampling is not a new method for detection of respiratory viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059288/
SHA: f3b46e7e8f58799207cc44515f859c1daf5e4dfc
Authors: Houspie, Lieselot; De Coster, Sarah; Keyaerts, Els; Narongsack, Phouthalack; De Roy, Rikka; Talboom, Ive; Sisk, Maur... | How is exhaled breath condensate used in viral research? | 5,193 | the isolation of respiratory viruses | 548 |
1,582 | Exhaled breath condensate sampling is not a new method for detection of respiratory viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059288/
SHA: f3b46e7e8f58799207cc44515f859c1daf5e4dfc
Authors: Houspie, Lieselot; De Coster, Sarah; Keyaerts, Els; Narongsack, Phouthalack; De Roy, Rikka; Talboom, Ive; Sisk, Maur... | How many patients were i this study? | 5,194 | 102 | 609 |
1,582 | Exhaled breath condensate sampling is not a new method for detection of respiratory viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059288/
SHA: f3b46e7e8f58799207cc44515f859c1daf5e4dfc
Authors: Houspie, Lieselot; De Coster, Sarah; Keyaerts, Els; Narongsack, Phouthalack; De Roy, Rikka; Talboom, Ive; Sisk, Maur... | What was the conclusion of this study? | 5,195 | EBC collection using the RTube™ is not reliable for diagnosis of respiratory infections | 1,673 |
1,582 | Exhaled breath condensate sampling is not a new method for detection of respiratory viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059288/
SHA: f3b46e7e8f58799207cc44515f859c1daf5e4dfc
Authors: Houspie, Lieselot; De Coster, Sarah; Keyaerts, Els; Narongsack, Phouthalack; De Roy, Rikka; Talboom, Ive; Sisk, Maur... | How long did the patient breath into the RTube? | 5,196 | 10 minutes | 4,107 |
1,582 | Exhaled breath condensate sampling is not a new method for detection of respiratory viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059288/
SHA: f3b46e7e8f58799207cc44515f859c1daf5e4dfc
Authors: Houspie, Lieselot; De Coster, Sarah; Keyaerts, Els; Narongsack, Phouthalack; De Roy, Rikka; Talboom, Ive; Sisk, Maur... | What followed the reverse transcription step in the analysis? | 5,197 | denaturation step | 9,620 |
1,582 | Exhaled breath condensate sampling is not a new method for detection of respiratory viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059288/
SHA: f3b46e7e8f58799207cc44515f859c1daf5e4dfc
Authors: Houspie, Lieselot; De Coster, Sarah; Keyaerts, Els; Narongsack, Phouthalack; De Roy, Rikka; Talboom, Ive; Sisk, Maur... | What was the last step in the analysis? | 5,198 | amplification step | 9,670 |
1,582 | Exhaled breath condensate sampling is not a new method for detection of respiratory viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059288/
SHA: f3b46e7e8f58799207cc44515f859c1daf5e4dfc
Authors: Houspie, Lieselot; De Coster, Sarah; Keyaerts, Els; Narongsack, Phouthalack; De Roy, Rikka; Talboom, Ive; Sisk, Maur... | What percentage of the patients were between 20 and 30 years old in this study? | 5,199 | 52% | 9,888 |
1,582 | Exhaled breath condensate sampling is not a new method for detection of respiratory viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059288/
SHA: f3b46e7e8f58799207cc44515f859c1daf5e4dfc
Authors: Houspie, Lieselot; De Coster, Sarah; Keyaerts, Els; Narongsack, Phouthalack; De Roy, Rikka; Talboom, Ive; Sisk, Maur... | Why is EBC an attractive method for screening? | 5,200 | easy to perform and can be conducted in a home environment | 12,629 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is the leading cause of death among children after the age of 1 month? | 502 | Pneumonia remains the leading cause of death in children outside the neonatal period, | 295 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | How has the number of childhood pneumonia been reduced? | 504 | New conjugate vaccines against Haemophilus influenzae type b and Streptococcus pneumoniae have contributed to decreases in radiologic, clinical and complicated pneumonia cases | 566 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What percentage of childhood deaths are due to pneumonia? | 507 | approximately 900,000 of the estimated 6.3 million child deaths in 2013 | 1,438 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | How has the childhood population grown in the last two decades? | 510 | global childhood population from 605 million in 2000 to 664 million in 2015 | 2,274 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is the reduction in the number of childhood pneumonia cases? | 511 | Recent data suggest that there has been a 25% decrease in the incidence of pneumonia, from 0.29 episodes per child year in low-and middle-income countries in 2000, to 0.22 episodes per child year in 2010 [3] . This is substantiated by a 58% decrease in pneumonia-associated disability-adjusted life years between 1990 an... | 2,356 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | How much is the reduction in the childhood pneumonia deaths? | 512 | Pneumonia deaths decreased from 1.8 million in 2000 to 900,000 in 2013 | 2,772 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | Childhood pneumonia rate for high income countries vs low and middle income countries. | 513 | The incidence in high-income countries is estimated at 0.015 episodes per child year, compared to 0.22 episodes per child year in low-and middle-income countries [3] . On average, 1 in 66 children in high-income countries is affected by pneumonia per year, compared to 1 in 5 children in low-and middle-income countries. | 3,310 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What percentage of childhood pneumonia deaths occur outside hospital in low and middle income countries? | 514 | up to 81% of severe pneumonia deaths occur outside a hospital | 3,756 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | Case Fatality Rates for Childhood Pneumonia in high income vs low and middle income countries. | 515 | the case fatality rate is estimated to be almost 10-fold higher in low-and middle-income countries as compared to high-income countries | 3,872 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | How can childhood pneumonia affect the subsequent health of a person? | 516 | Early life pneumonia can impair longterm lung health by decreasing lung function [6] . Severe or recurrent pneumonia can have a worse effect on lung function; increasing evidence suggests that chronic obstructive pulmonary disease might be related to early childhood pneumonia | 4,098 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is the increase in the risk of respiratory disease after having childhood pneumonia. | 517 | The risk of developing at least one of the major sequelae was estimated as 6% after an ambulatory pneumonia event and 14% after an episode of hospitalized pneumonia. | 4,662 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | Which is the best method to identify pneumonia in a person? | 518 | Chest radiologic changes have been considered the gold standard for defining a pneumonia event | 5,040 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is responsible for the reduction of radiologic pneumonia? | 520 | Widespread use of pneumococcal conjugate vaccination and Haemophilus influenzae type B conjugate vaccination has decreased the incidence of radiologic pneumonia. | 6,100 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is the percentage reduction in pneumonia cases due to vaccination? | 521 | Haemophilus influenzae type B conjugate vaccination in high-burden communities, the vaccination was associated with an 18% decrease in radiologic pneumonia [13] . Introduction of pneumococcal conjugate vaccination was associated with a 26% decrease in radiologic pneumonia in California between 1995 and 1998 [14] . In v... | 6,343 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is the revised WHO definition of Bacterial Pneumonia? | 522 | A revised case definition of "presumed bacterial pneumonia" has been introduced, and this definition includes pneumonia cases with WHO-defined alveolar consolidation, as well as those with other abnormal chest radiograph infiltrates and a serum C-reactive protein of at least 40 mg/L | 7,735 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.