document_id int64 185 2.68k | context stringlengths 2.88k 70.8k | question stringlengths 11 194 | id int64 225 5.32k | answer stringlengths 1 933 | answer_start int64 157 69k |
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1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is the reduction in bacterial pneumonia under the revised WHO definition of bacterial pneumonia? | 524 | Using the revised definition, the 10-valent pneumococcal conjugate vaccine (pneumococcal conjugate vaccination-10), had a vaccine efficacy of 22% in preventing presumed bacterial pneumonia in young children in South America [22] , and pneumococcal conjugate vaccination-13 had a vaccine efficacy of 39% in preventing pre... | 8,257 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What caused the increase in the incidence of empyema in children in the recent past? | 530 | An increased incidence of empyema in children was noted in some high-income countries following pneumococcal conjugate vaccination-7 introduction, and this was attributed to pneumococcal serotypes not included in pneumococcal conjugate vaccination-7, especially 3 and 19A | 9,031 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | How have the incidence Empyema been reduced? | 532 | These trends have been reversed since the introduction of pneumococcal conjugate vaccination-13. Data from the United States suggest that empyema decreased by 50% in children younger than 5 years | 9,813 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What pneumonia related or chest conditions indicate the need for child radiography? | 533 | chest radiography should not be routinely performed in children with ambulatory pneumonia [31] [32] [33] . Indications for chest radiography include hospitalization, severe hypoxemia or respiratory distress, failed initial antibiotic therapy, or suspicion for other diseases (tuberculosis, inhaled foreign body) or compl... | 10,334 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What chest diseases and pneumonia were identified as leading causes prior to the availability of vaccines? | 534 | prior to availability of new conjugate vaccines confirmed S. pneumoniae and H. influenzae type B as the most important bacterial causes of pneumonia, with Staphylococcus aureus and Klebsiella pneumoniae associated with some severe cases. Respiratory syncytial virus was the leading viral cause, identified in 15-40% of p... | 11,677 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | Why has pertussis immunity in infants has decreased in infants? | 535 | Because pertussis immunity after acellular pertussis vaccination is less long-lasting than immunity after wild-type infection or whole-cell vaccination, many women of child-bearing age have waning pertussis antibody levels. | 13,760 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is the effect of childhood tuberculosis in childhood pneumonia? | 536 | A recent systematic review of tuberculosis as a comorbidity of childhood pneumonia reported culture-confirmed disease in about 8% of cases [50] . Because intrathoracic tuberculosis disease is only culture-confirmed in a minority of cases, the true burden could be even higher; tuberculosis could therefore be an importan... | 15,402 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What are the risk factors in childhood pneumonia? | 537 | incomplete or inadequate vaccination must be considered as a major preventable risk factor for childhood pneumonia. Other risk factors include low birth weight, which is associated with 3.2 times increased odds of severe pneumonia in low-and middle-income countries, and 1.8 times increased odds in high-income countries... | 16,115 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | How does air pollution affect the incidence of childhood pneumonia? | 538 | Indoor air pollution from use of solid or biomass fuels increases odds of pneumonia by 1.6 times; lack of measles vaccination by the end of the first year of age increases odds of pneumonia by 1.8 times | 16,987 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is the strongest risk factor for childhood pneumonia? | 539 | The single strongest risk factor for pneumonia is HIV infection, which is especially prevalent in children in sub-Saharan Africa. HIV-infected children have 6 times increased odds of developing severe pneumonia or of death compared to HIV-uninfected children | 17,514 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is the global coverage of influenza and pneumonia vaccines? | 540 | By the end of 2015, Haemophilus influenzae type B conjugate vaccination had been introduced in 73 countries, with global coverage estimated at 68%. However, inequities are still apparent among regions: in the Americas coverage is estimated at 90%, while in the Western Pacific it is only 25%. By 2015, pneumococcal conju... | 18,325 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | Is influenza vaccination during pregnancy safe? How long does it protect the child? | 541 | Influenza vaccination during pregnancy is safe, provides reasonable maternal protection against influenza, and also protects infants for a limited period from confirmed influenza infection (vaccine efficacy 63% in Bangladesh [63] and 50.4% in South Africa [64] ). However as antibody levels drop sharply after birth, inf... | 19,437 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is emphyema? | 923 | a rare complication of pneumonia | 8,998 |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | How is the term end point consolidation described with regard to pneumonia diagnosis? | 4,573 | as a dense or fluffy opacity that occupies a portion or whole of a lobe, or the entire lung. | 5,539 |
1,575 | A 3-year prospective study of the epidemiology of acute respiratory viral infections in hospitalized children in Shenzhen, China
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181804/
SHA: ef5fe7296ec8baf90d974cf5737af0da3ed403ea
Authors: He, Ying; Lin, Guang-Yu; Wang, Qiong; Cai, Xiao-Ying; Zhang, Yin-Hui; Lin, Chua... | What viruses have been responsible for most common childhood acute respiratory track infections (ARTI)? | 550 | The most frequently reported viruses include respiratory syncytial virus (RSV), influenza viruses A and B (IAV, IBV), parainfluenza viruses (PIVs), human rhinovirus (HRV) and adenovirus (ADV), | 2,534 |
1,575 | A 3-year prospective study of the epidemiology of acute respiratory viral infections in hospitalized children in Shenzhen, China
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181804/
SHA: ef5fe7296ec8baf90d974cf5737af0da3ed403ea
Authors: He, Ying; Lin, Guang-Yu; Wang, Qiong; Cai, Xiao-Ying; Zhang, Yin-Hui; Lin, Chua... | Are there any vaccines against to protect against respiratory viral infections? | 553 | Currently, there are no approved vaccines or medications available for most of the respiratory viruses | 3,172 |
2,585 | Spread from the Sink to the Patient: In Situ Study Using Green Fluorescent Protein (GFP)-Expressing Escherichia coli To Model Bacterial Dispersion from Hand-Washing Sink-Trap Reservoirs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377511/
SHA: 615071c8c959f24857b1bad521cc432b59719bfb
Authors: Kotay, Shireen; Chai, ... | Which type of bacteria are implicated in carrying genes of drug resistance? | 544 | Gammaproteobacteria | 507 |
2,585 | Spread from the Sink to the Patient: In Situ Study Using Green Fluorescent Protein (GFP)-Expressing Escherichia coli To Model Bacterial Dispersion from Hand-Washing Sink-Trap Reservoirs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377511/
SHA: 615071c8c959f24857b1bad521cc432b59719bfb
Authors: Kotay, Shireen; Chai, ... | What may be a likely cause of sink-to-sink spreading of pathogens in the hospital setting? | 545 | via a common sanitary pipe | 19,969 |
1,556 | The impact of rapid molecular diagnostic testing for respiratory viruses on outcomes for emergency department patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617970/
SHA: eea9d5e3d2244b3ecfb5e909515e00a4a3cabaa7
Authors: Wabe, Nasir; Li, Ling; Lindeman, Robert; Yimsung, Ruth; Dahm, Maria R; Clezy, Kate; McLen... | What types of acute respiratory infections can be screened and diagnosed with multiplex PCR? | 327 | influenza and parainfluenza viruses, RSV, adenovirus, rhinovirus, human metapneumovirus, enterovirus, bocavirus and coronavirus | 2,525 |
1,569 | Techniques to Study Antigen-Specific B Cell Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667631/
SHA: ee632fa425607e8ff91fc3730bc0782d43ce9c0c
Authors: Boonyaratanakornkit, Jim; Taylor, Justin J.
Date: 2019-07-24
DOI: 10.3389/fimmu.2019.01694
License: cc-by
Abstract: Antibodies against foreign antigens a... | What is the role of antibodies during infection? | 465 | Antibodies against foreign antigens are a critical component of the overall immune response and can facilitate pathogen clearance during a primary infection and also protect against subsequent infections. | 283 |
1,569 | Techniques to Study Antigen-Specific B Cell Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667631/
SHA: ee632fa425607e8ff91fc3730bc0782d43ce9c0c
Authors: Boonyaratanakornkit, Jim; Taylor, Justin J.
Date: 2019-07-24
DOI: 10.3389/fimmu.2019.01694
License: cc-by
Abstract: Antibodies against foreign antigens a... | How can antibodies also create health problems? | 467 | Dysregulation of the antibody response can lead to an autoimmune disease, malignancy, or enhanced infection. | 488 |
1,569 | Techniques to Study Antigen-Specific B Cell Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667631/
SHA: ee632fa425607e8ff91fc3730bc0782d43ce9c0c
Authors: Boonyaratanakornkit, Jim; Taylor, Justin J.
Date: 2019-07-24
DOI: 10.3389/fimmu.2019.01694
License: cc-by
Abstract: Antibodies against foreign antigens a... | Which technology invention produced antibodies that are clones of a unique parent cell? | 474 | in the 1970s with the development of hybridoma technology to produce monoclonal antibodies | 2,257 |
1,569 | Techniques to Study Antigen-Specific B Cell Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667631/
SHA: ee632fa425607e8ff91fc3730bc0782d43ce9c0c
Authors: Boonyaratanakornkit, Jim; Taylor, Justin J.
Date: 2019-07-24
DOI: 10.3389/fimmu.2019.01694
License: cc-by
Abstract: Antibodies against foreign antigens a... | What mechanism is responsible for the creation of diversified repertoire for antibodies? | 476 | somatic rearrangement during B cell differentiation was responsible for antibody diversification | 2,372 |
1,569 | Techniques to Study Antigen-Specific B Cell Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667631/
SHA: ee632fa425607e8ff91fc3730bc0782d43ce9c0c
Authors: Boonyaratanakornkit, Jim; Taylor, Justin J.
Date: 2019-07-24
DOI: 10.3389/fimmu.2019.01694
License: cc-by
Abstract: Antibodies against foreign antigens a... | What developments have been made possible by the study of B-cell repertoire? | 478 | (1) vaccine candidates that elicit protective antibodies; (2) antibodies that prevent disease when given prophylactically; and (3) antibodies that can be given as therapy after the onset of disease. | 2,996 |
1,569 | Techniques to Study Antigen-Specific B Cell Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667631/
SHA: ee632fa425607e8ff91fc3730bc0782d43ce9c0c
Authors: Boonyaratanakornkit, Jim; Taylor, Justin J.
Date: 2019-07-24
DOI: 10.3389/fimmu.2019.01694
License: cc-by
Abstract: Antibodies against foreign antigens a... | What motivates the study of the rare B-cells that produce Broadly Neutralizing Antibodies (bnAb)? | 485 | discovery of broadly neutralizing antibodies (bnAbs) that protect against infection across diverse viral isolates has intensified efforts to understand the developmental pathway of the rare B cells that produce these antibodies | 3,589 |
1,569 | Techniques to Study Antigen-Specific B Cell Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667631/
SHA: ee632fa425607e8ff91fc3730bc0782d43ce9c0c
Authors: Boonyaratanakornkit, Jim; Taylor, Justin J.
Date: 2019-07-24
DOI: 10.3389/fimmu.2019.01694
License: cc-by
Abstract: Antibodies against foreign antigens a... | How has the study of B-cells helped the treatment for Respiratory syncytial virus (RSV)? | 489 | For RSV, stabilized versions of the fusion (F) protein in the pre-fusion conformation have led to insights in the B cell's response to infection and has generated potentially safer and more efficacious vaccine candidates | 4,083 |
1,569 | Techniques to Study Antigen-Specific B Cell Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667631/
SHA: ee632fa425607e8ff91fc3730bc0782d43ce9c0c
Authors: Boonyaratanakornkit, Jim; Taylor, Justin J.
Date: 2019-07-24
DOI: 10.3389/fimmu.2019.01694
License: cc-by
Abstract: Antibodies against foreign antigens a... | How are the studies on B-cells helping the development of a universal influenza vaccine? | 490 | Influenza also performs fusion through the stem region of the hemagglutinin protein, and the identification of B cells that target this relatively conserved site has spurred research on the development of a universal influenza vaccine ( | 4,315 |
1,569 | Techniques to Study Antigen-Specific B Cell Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667631/
SHA: ee632fa425607e8ff91fc3730bc0782d43ce9c0c
Authors: Boonyaratanakornkit, Jim; Taylor, Justin J.
Date: 2019-07-24
DOI: 10.3389/fimmu.2019.01694
License: cc-by
Abstract: Antibodies against foreign antigens a... | What role B-cell play in malaria infection and prevention? | 494 | Rare memory B cells producing antibodies specific for the EBV fusion machinery have been isolated; these can neutralize both B cell and epithelial cell infection (20). A new paradigm in malaria vaccine development is also emerging with the discovery of IgM+ and IgD+ memory B cells targeting the Merozoite Surface Protei... | 4,790 |
1,569 | Techniques to Study Antigen-Specific B Cell Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667631/
SHA: ee632fa425607e8ff91fc3730bc0782d43ce9c0c
Authors: Boonyaratanakornkit, Jim; Taylor, Justin J.
Date: 2019-07-24
DOI: 10.3389/fimmu.2019.01694
License: cc-by
Abstract: Antibodies against foreign antigens a... | How can the study of B-cells help in the prevention and treatment of autoimmune diseases? | 497 | The study of autoantigen-specific B cells and a detailed analysis of B cell subsets with pathogenic potential in humans could lead to a better understanding of how to prevent and treat autoimmune diseases. | 6,415 |
1,551 | Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049846/
SHA: edee452881f826fb72c58ee68a982789b12aa99d
Authors: Altamimi, Asmaa; Abu-Saris, Raghib; El-Me... | When was the Middle East Respiratory Syndrome Coronavirus isolated first? | 557 | (MERS-CoV) was first isolated in 2012, in a 60-year-old man who died in Jeddah, KSA due to severe acute pneumonia and multiple organ failure | 2,273 |
1,551 | Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049846/
SHA: edee452881f826fb72c58ee68a982789b12aa99d
Authors: Altamimi, Asmaa; Abu-Saris, Raghib; El-Me... | What is the Case fatality rate for MERS Coronavirus? | 558 | Recent fatality rate (CFR) of 21% | 2,686 |
1,551 | Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049846/
SHA: edee452881f826fb72c58ee68a982789b12aa99d
Authors: Altamimi, Asmaa; Abu-Saris, Raghib; El-Me... | How does gender influence MERS-COV infection? | 559 | MERS-CoV infects males more than females | 2,869 |
1,551 | Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049846/
SHA: edee452881f826fb72c58ee68a982789b12aa99d
Authors: Altamimi, Asmaa; Abu-Saris, Raghib; El-Me... | Which is the source animal for the MERS-COV? | 560 | Dromedary camels are the major animal source of MERS-CoV transmission to humans. | 3,322 |
1,551 | Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049846/
SHA: edee452881f826fb72c58ee68a982789b12aa99d
Authors: Altamimi, Asmaa; Abu-Saris, Raghib; El-Me... | What is the median time until death in MERS-COV? | 562 | median time until death is 11-13 days (range 5-27 days) among severely ill patients | 3,925 |
1,551 | Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049846/
SHA: edee452881f826fb72c58ee68a982789b12aa99d
Authors: Altamimi, Asmaa; Abu-Saris, Raghib; El-Me... | What is the incubation period for MERS-COV? | 563 | incubation period of 16 days with a mean of 5-6 days [ | 3,850 |
1,551 | Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049846/
SHA: edee452881f826fb72c58ee68a982789b12aa99d
Authors: Altamimi, Asmaa; Abu-Saris, Raghib; El-Me... | What is the treatment for MERS-COV? | 564 | ere is no specific treatment for MERS-CoV. Like most viral infections, the treatment options are supportive and symptomatic | 4,155 |
1,551 | Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049846/
SHA: edee452881f826fb72c58ee68a982789b12aa99d
Authors: Altamimi, Asmaa; Abu-Saris, Raghib; El-Me... | What age group had the most MERS-COV infections? | 565 | majority of confirmed cases of MERS-CoV were reported among people aged 40 and above | 11,825 |
1,594 | Gemcitabine and Nucleos(t)ide Synthesis Inhibitors Are Broad-Spectrum Antiviral Drugs that Activate Innate Immunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923505/
SHA: f1e1e2511e051195c8327a56d5c311a2dd4ab6b3
Authors: Shin, Hye Jin; Kim, Chonsaeng; Cho, Sungchan
Date: 2018-04-20
DOI: 10.3390/v10040211
License... | Why are nucleosides analogs used for chemotheraphy? | 5,232 | they inhibit cellular DNA/RNA polymerases | 1,328 |
1,594 | Gemcitabine and Nucleos(t)ide Synthesis Inhibitors Are Broad-Spectrum Antiviral Drugs that Activate Innate Immunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923505/
SHA: f1e1e2511e051195c8327a56d5c311a2dd4ab6b3
Authors: Shin, Hye Jin; Kim, Chonsaeng; Cho, Sungchan
Date: 2018-04-20
DOI: 10.3390/v10040211
License... | What nucleoside analog is the focus of the current study? | 5,233 | gemcitabine | 6,040 |
1,594 | Gemcitabine and Nucleos(t)ide Synthesis Inhibitors Are Broad-Spectrum Antiviral Drugs that Activate Innate Immunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923505/
SHA: f1e1e2511e051195c8327a56d5c311a2dd4ab6b3
Authors: Shin, Hye Jin; Kim, Chonsaeng; Cho, Sungchan
Date: 2018-04-20
DOI: 10.3390/v10040211
License... | Gemcitabine has been shown to have antiviral activity against which viruses? | 5,234 | Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), Zika virus (ZIKV), HCV, poliovirus (PV), influenza A virus (IAV), HIV, and enteroviruses (EV) | 6,863 |
1,594 | Gemcitabine and Nucleos(t)ide Synthesis Inhibitors Are Broad-Spectrum Antiviral Drugs that Activate Innate Immunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923505/
SHA: f1e1e2511e051195c8327a56d5c311a2dd4ab6b3
Authors: Shin, Hye Jin; Kim, Chonsaeng; Cho, Sungchan
Date: 2018-04-20
DOI: 10.3390/v10040211
License... | How does gemcitabine disrupt viral activity? | 5,235 | by targeting the salvage pathway of pyrimidine biosynthesis | 14,050 |
1,570 | Identification and characterisation of the CD40-ligand of Sigmodon hispidus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063397/
SHA: edf2997357501734a93c1b7e16d44e86a7d20853
Authors: Russell, Marsha S.; Muralidharan, Abenaya; Larocque, Louise; Cao, Jingxin; Deschambault, Yvon; Varga, Jessie; Thulasi Raman, Sathya ... | Why are cotton rats considered a strong animal model for biomedical research? | 1,631 | its well defined immunological and genetic information, costeffectiveness, and abundant inbred strains and research reagents | 2,066 |
1,570 | Identification and characterisation of the CD40-ligand of Sigmodon hispidus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063397/
SHA: edf2997357501734a93c1b7e16d44e86a7d20853
Authors: Russell, Marsha S.; Muralidharan, Abenaya; Larocque, Louise; Cao, Jingxin; Deschambault, Yvon; Varga, Jessie; Thulasi Raman, Sathya ... | What is the structure of the CD40 Ligand? | 1,632 | a sandwiched extracellular structure composed of a β-sheet, α-helix loop, and a β-sheet | 4,149 |
1,570 | Identification and characterisation of the CD40-ligand of Sigmodon hispidus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063397/
SHA: edf2997357501734a93c1b7e16d44e86a7d20853
Authors: Russell, Marsha S.; Muralidharan, Abenaya; Larocque, Louise; Cao, Jingxin; Deschambault, Yvon; Varga, Jessie; Thulasi Raman, Sathya ... | What is the effect of CD40L on Dendritic Cells? | 1,633 | it promotes cytokine production, the induction of cell surface co-stimulatory molecules, and facilitates the cross-presentation of antigen by these cells | 4,774 |
1,570 | Identification and characterisation of the CD40-ligand of Sigmodon hispidus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063397/
SHA: edf2997357501734a93c1b7e16d44e86a7d20853
Authors: Russell, Marsha S.; Muralidharan, Abenaya; Larocque, Louise; Cao, Jingxin; Deschambault, Yvon; Varga, Jessie; Thulasi Raman, Sathya ... | What is the effect of CD40L on B Cells? | 1,634 | it promotes germinal center formation, immunoglobulin (Ig) isotype switching, somatic hypermutation to enhance antigen affinity, and lastly, the formation of long-lived plasma cells and memory B cells | 5,079 |
1,563 | Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819164/
SHA: ee0c318d282c0089cca94f0b2ea4d90db2ab9f8a
Authors: Maccioni, Livia; Weber, Susanne; Elgizouli, Magdeldin; Stoehlker, Anne-Sophie; Geist, Ilona; Peter, Hans-Hart... | What conditions are considered upper respiratory tracts infections? | 328 | common cold, pharyngitis, otitis, sinusitis, laryngotracheitis, epiglottitis | 2,282 |
1,563 | Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819164/
SHA: ee0c318d282c0089cca94f0b2ea4d90db2ab9f8a
Authors: Maccioni, Livia; Weber, Susanne; Elgizouli, Magdeldin; Stoehlker, Anne-Sophie; Geist, Ilona; Peter, Hans-Hart... | What conditions are considered lower respiratory tract infections? | 329 | bronchitis, pneumonia and bronchiolitis | 2,392 |
1,563 | Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819164/
SHA: ee0c318d282c0089cca94f0b2ea4d90db2ab9f8a
Authors: Maccioni, Livia; Weber, Susanne; Elgizouli, Magdeldin; Stoehlker, Anne-Sophie; Geist, Ilona; Peter, Hans-Hart... | What immune cells are primarily involved in eliminating virus-infected cells? | 330 | NK cells (CD3-/CD16+/CD56+) | 19,410 |
1,563 | Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819164/
SHA: ee0c318d282c0089cca94f0b2ea4d90db2ab9f8a
Authors: Maccioni, Livia; Weber, Susanne; Elgizouli, Magdeldin; Stoehlker, Anne-Sophie; Geist, Ilona; Peter, Hans-Hart... | What molecules have been shown to hinder T cell responses to viral infections? | 331 | Excessive reactive oxygen species (ROS) | 20,524 |
1,563 | Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819164/
SHA: ee0c318d282c0089cca94f0b2ea4d90db2ab9f8a
Authors: Maccioni, Livia; Weber, Susanne; Elgizouli, Magdeldin; Stoehlker, Anne-Sophie; Geist, Ilona; Peter, Hans-Hart... | The accumulation of what molecule hinders phagocytic activity in T cells? | 332 | reactive oxygen species (ROS) | 20,534 |
1,549 | A Global Champion for Health—WHO’s Next?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924837/
SHA: f2f9088055600d4160e36db5cb6ea000916390a3
Authors: nan
Date: 2016-06-28
DOI: 10.1371/journal.pmed.1002059
License: cc-by
Abstract: In this month’s editorial, the PLOS Medicine Editors propose ideal qualities for the W... | When did the last Director General of the WHO resign? | 1,592 | June 30, 2017 | 603 |
1,549 | A Global Champion for Health—WHO’s Next?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924837/
SHA: f2f9088055600d4160e36db5cb6ea000916390a3
Authors: nan
Date: 2016-06-28
DOI: 10.1371/journal.pmed.1002059
License: cc-by
Abstract: In this month’s editorial, the PLOS Medicine Editors propose ideal qualities for the W... | Why might an organization like the WHO be necessary? | 1,593 | to promote, set standards in, and evaluate progress toward better health for people in all countries | 2,033 |
1,549 | A Global Champion for Health—WHO’s Next?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924837/
SHA: f2f9088055600d4160e36db5cb6ea000916390a3
Authors: nan
Date: 2016-06-28
DOI: 10.1371/journal.pmed.1002059
License: cc-by
Abstract: In this month’s editorial, the PLOS Medicine Editors propose ideal qualities for the W... | Where should the next Director General for the WHO come from? | 1,595 | a lowincome or middle-income country | 3,064 |
1,549 | A Global Champion for Health—WHO’s Next?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924837/
SHA: f2f9088055600d4160e36db5cb6ea000916390a3
Authors: nan
Date: 2016-06-28
DOI: 10.1371/journal.pmed.1002059
License: cc-by
Abstract: In this month’s editorial, the PLOS Medicine Editors propose ideal qualities for the W... | What traits should the new Director General of the WHO have? | 1,596 | open-minded and creative | 3,978 |
1,564 | A focus reduction neutralization assay for hepatitis C virus neutralizing antibodies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852297/
SHA: ee8dca216514deeed4c9415bc2ad8a78dc3d9670
Authors: Fournier, Carole; Duverlie, Gilles; François, Catherine; Schnuriger, Aurelie; Dedeurwaerder, Sarah; Brochot, Etienne; Capro... | What is the Hepatitis C virus? | 1,625 | enveloped, positive-stranded RNA virus | 2,967 |
1,564 | A focus reduction neutralization assay for hepatitis C virus neutralizing antibodies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852297/
SHA: ee8dca216514deeed4c9415bc2ad8a78dc3d9670
Authors: Fournier, Carole; Duverlie, Gilles; François, Catherine; Schnuriger, Aurelie; Dedeurwaerder, Sarah; Brochot, Etienne; Capro... | How many people have persistent hepatitis C virus? | 1,626 | 170 million people worldwide | 3,062 |
1,564 | A focus reduction neutralization assay for hepatitis C virus neutralizing antibodies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852297/
SHA: ee8dca216514deeed4c9415bc2ad8a78dc3d9670
Authors: Fournier, Carole; Duverlie, Gilles; François, Catherine; Schnuriger, Aurelie; Dedeurwaerder, Sarah; Brochot, Etienne; Capro... | What is the long-term risk of chronic hepatitis C infection? | 1,627 | cirrhosis and hepatocellular carcinoma | 3,219 |
1,564 | A focus reduction neutralization assay for hepatitis C virus neutralizing antibodies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852297/
SHA: ee8dca216514deeed4c9415bc2ad8a78dc3d9670
Authors: Fournier, Carole; Duverlie, Gilles; François, Catherine; Schnuriger, Aurelie; Dedeurwaerder, Sarah; Brochot, Etienne; Capro... | What antiviral treatments are used for hepatitis C infection? | 1,628 | pegylated alpha-interferon and ribavirin | 3,287 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | What is the main cause of death in the neonatal period of calves? | 2,129 | Calf septicemia | 1,971 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | Where was hepcidin first discovered? | 2,131 | human urine | 2,382 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | What is hepcidin? | 2,130 | low molecular weight, antimicrobial peptide hormone | 2,302 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | What organ produces hepcidin? | 2,132 | liver | 2,422 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | What stimulates the release of hepcidin? | 2,133 | inflammatory reactions and high Fe concentrations | 2,455 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | What element does hepcidin play a roles in regulating during metabolism? | 2,134 | Fe | 2,569 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | Is hepcidin toxic? | 2,135 | potentially toxic | 2,856 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | Why is iron critical to bacteria? | 2,136 | bacteria utilize Fe for survival, growth and proliferation | 2,972 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | How does hepcidin work in the duodenum? | 2,137 | control of excessive Fe absorption | 3,425 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | How does hepcidin affect macrophages? | 2,138 | regulation of Fe release | 3,372 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | What leads to oxidative stress in the body? | 2,139 | production of ROS | 3,802 |
1,560 | Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146304/
SHA: efcd7d171bb51acf2ef0a631901900497957a3be
Authors: Erkilic, E. E.; Erdogan, H. M.; Ogun, M.; Kirmizigul, A. H.; Gokce, E.; Kuru, M.; Kukurt, A.
Date: 201... | What parameter is used to measure antioxidant levels? | 2,140 | superoxide dismutase | 11,390 |
1,561 | Acute Hemorrhagic Encephalitis Responding to Combined Decompressive Craniectomy, Intravenous Immunoglobulin, and Corticosteroid Therapies: Association with Novel RANBP2 Variant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857578/
SHA: ef6638accc1ef599ad1aafd47b3a86f2b904cc76
Authors: Alawadhi, Abdulla; Saint-Martin... | What is Acute hemorrhagic encephalomyelitis? | 3,032 | a rare form of acute disseminated encephalomyelitis | 546 |
1,561 | Acute Hemorrhagic Encephalitis Responding to Combined Decompressive Craniectomy, Intravenous Immunoglobulin, and Corticosteroid Therapies: Association with Novel RANBP2 Variant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857578/
SHA: ef6638accc1ef599ad1aafd47b3a86f2b904cc76
Authors: Alawadhi, Abdulla; Saint-Martin... | What are the salient findings in Acute hemorrhagic encephalomyelitis? | 3,033 | fulminant encephalopathy with hemorrhagic necrosis | 615 |
1,561 | Acute Hemorrhagic Encephalitis Responding to Combined Decompressive Craniectomy, Intravenous Immunoglobulin, and Corticosteroid Therapies: Association with Novel RANBP2 Variant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857578/
SHA: ef6638accc1ef599ad1aafd47b3a86f2b904cc76
Authors: Alawadhi, Abdulla; Saint-Martin... | What is RANBP2? | 3,034 | nuclear pore protein | 3,370 |
1,561 | Acute Hemorrhagic Encephalitis Responding to Combined Decompressive Craniectomy, Intravenous Immunoglobulin, and Corticosteroid Therapies: Association with Novel RANBP2 Variant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857578/
SHA: ef6638accc1ef599ad1aafd47b3a86f2b904cc76
Authors: Alawadhi, Abdulla; Saint-Martin... | What is the suggested role of RANBP2 in the cell? | 3,035 | intracellular protein trafficking or energy maintenance and homeostasis of neuronal cells | 3,506 |
1,561 | Acute Hemorrhagic Encephalitis Responding to Combined Decompressive Craniectomy, Intravenous Immunoglobulin, and Corticosteroid Therapies: Association with Novel RANBP2 Variant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857578/
SHA: ef6638accc1ef599ad1aafd47b3a86f2b904cc76
Authors: Alawadhi, Abdulla; Saint-Martin... | What is the hallmark finding of acute necrotizing encephalopathy? | 3,036 | multiple, symmetric brain lesions located in the thalami bilaterally, putamina, deep periventricular white matter, cerebellum, and brainstem | 3,762 |
1,561 | Acute Hemorrhagic Encephalitis Responding to Combined Decompressive Craniectomy, Intravenous Immunoglobulin, and Corticosteroid Therapies: Association with Novel RANBP2 Variant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857578/
SHA: ef6638accc1ef599ad1aafd47b3a86f2b904cc76
Authors: Alawadhi, Abdulla; Saint-Martin... | What could trigger acute necrotizing encephalopathy? | 3,037 | viral infection in previously healthy children | 3,931 |
1,561 | Acute Hemorrhagic Encephalitis Responding to Combined Decompressive Craniectomy, Intravenous Immunoglobulin, and Corticosteroid Therapies: Association with Novel RANBP2 Variant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857578/
SHA: ef6638accc1ef599ad1aafd47b3a86f2b904cc76
Authors: Alawadhi, Abdulla; Saint-Martin... | When did she present with rapidly progressive right-hand weakness? | 3,038 | 1 month later | 6,040 |
1,562 | New Isoxazolidine-Conjugates of Quinazolinones—Synthesis, Antiviral and Cytostatic Activity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273226/
SHA: eefddcf51f8426ecaa9e3ace144dadfb34a74cf5
Authors: Piotrowska, Dorota G.; Andrei, Graciela; Schols, Dominique; Snoeck, Robert; Grabkowska-Drużyc, Magdalena
Date: 2016-... | Compounds from what framework have shown promising anticancer and antiviral properties? | 3,039 | quinazolin-4-one | 2,259 |
1,562 | New Isoxazolidine-Conjugates of Quinazolinones—Synthesis, Antiviral and Cytostatic Activity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273226/
SHA: eefddcf51f8426ecaa9e3ace144dadfb34a74cf5
Authors: Piotrowska, Dorota G.; Andrei, Graciela; Schols, Dominique; Snoeck, Robert; Grabkowska-Drużyc, Magdalena
Date: 2016-... | The replication of what virus is strongly inhibited by 2-(4-hydroxybenzyl)quinazolin-4(3H)-one (1)? | 3,040 | tobacco mosaic virus | 2,689 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | What causes acute respiratory illness in young children? | 4,059 | Human metapneumovirus (HMPV) | 427 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | What is the molecular structure of the Human metapneumovirus (HMPV)? | 4,060 | single-stranded RNA virus | 1,725 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | What virus is closely related to the human respiratory syncytial virus (RSV)? | 4,061 | Human metapneumovirus (HMPV) | 1,691 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | What diseases are caused by HMPV? | 4,062 | mild upper respiratory infection to bronchiolitis and pneumonia | 1,911 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | How large is the HMPV genome? | 4,063 | 13 kb | 2,108 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | How many open reading frames are in the HMPV genome? | 4,064 | eight | 2,128 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | What are the two major genotypes of HMPV? | 4,065 | A and B | 2,486 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | What is the most common subgroup of HMPV? | 4,066 | HMPV A2 | 2,566 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | Who accounted for 44% of HMPV positive cases in Kenya between 2007 and 2011? | 4,067 | children under 6 months of age | 3,234 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | What does this study describe? | 4,068 | a whole genome sequencing (WGS) approach for HMPV | 5,474 |
1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
SHA: f5ae3f66face323615df39d838e056ab5fcc98df
Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | What was the difference in the group A and B genomes? | 4,069 | The length of the F-M2 intergenic region | 7,202 |
1,579 | Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012–2013: A PCR/Electrospray Ionization Mass Spectrometry Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635751/
SHA: ef6361c7bffb9e92f397d7004bfb3a9c804d7c6a
Authors: Shih, Hsin-I; Wang, Hsuan-Chen; Su... | What was the purpose of this study? | 4,077 | to comprehensively investigate the viral epidemiology of adult RTIs | 850 |
1,579 | Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012–2013: A PCR/Electrospray Ionization Mass Spectrometry Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635751/
SHA: ef6361c7bffb9e92f397d7004bfb3a9c804d7c6a
Authors: Shih, Hsin-I; Wang, Hsuan-Chen; Su... | How many control samples were used in this study? | 4,078 | 27 | 1,343 |
1,579 | Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012–2013: A PCR/Electrospray Ionization Mass Spectrometry Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635751/
SHA: ef6361c7bffb9e92f397d7004bfb3a9c804d7c6a
Authors: Shih, Hsin-I; Wang, Hsuan-Chen; Su... | What was the prevalence of coinfection? | 4,079 | 4.1% of cases | 1,941 |
1,579 | Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012–2013: A PCR/Electrospray Ionization Mass Spectrometry Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635751/
SHA: ef6361c7bffb9e92f397d7004bfb3a9c804d7c6a
Authors: Shih, Hsin-I; Wang, Hsuan-Chen; Su... | What risks factors were associated with lower RTIs? | 4,080 | parainfluenza infection, old age, and immunosuppression | 2,582 |
1,579 | Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012–2013: A PCR/Electrospray Ionization Mass Spectrometry Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635751/
SHA: ef6361c7bffb9e92f397d7004bfb3a9c804d7c6a
Authors: Shih, Hsin-I; Wang, Hsuan-Chen; Su... | What tests can simultaneously identify and subtype multiple respiratory viruses? | 4,081 | multilocus polymerase chain reaction coupled with electrospray ionization mass spectrometry | 4,633 |
1,579 | Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012–2013: A PCR/Electrospray Ionization Mass Spectrometry Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635751/
SHA: ef6361c7bffb9e92f397d7004bfb3a9c804d7c6a
Authors: Shih, Hsin-I; Wang, Hsuan-Chen; Su... | What was the definition for an immunocompromised state in this study? | 4,082 | corticosteroid treatment, solid organ or hematopoietic stem cell recipient, or chemotherapy for an underlying malignancy during the past 6 months | 7,015 |
1,579 | Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012–2013: A PCR/Electrospray Ionization Mass Spectrometry Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635751/
SHA: ef6361c7bffb9e92f397d7004bfb3a9c804d7c6a
Authors: Shih, Hsin-I; Wang, Hsuan-Chen; Su... | What was the length of the study? | 4,083 | 9-month | 11,268 |
1,579 | Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012–2013: A PCR/Electrospray Ionization Mass Spectrometry Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635751/
SHA: ef6361c7bffb9e92f397d7004bfb3a9c804d7c6a
Authors: Shih, Hsin-I; Wang, Hsuan-Chen; Su... | How many patients had acute RTIs? | 4,084 | 263 | 11,333 |
1,579 | Viral Respiratory Tract Infections in Adult Patients Attending Outpatient and Emergency Departments, Taiwan, 2012–2013: A PCR/Electrospray Ionization Mass Spectrometry Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635751/
SHA: ef6361c7bffb9e92f397d7004bfb3a9c804d7c6a
Authors: Shih, Hsin-I; Wang, Hsuan-Chen; Su... | What was the most frequent coinfection? | 4,085 | rhinovirus | 20,799 |
1,583 | A super-spreading ewe infects hundreds with Q fever at a farmers' market in Germany
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618839/
SHA: ee1b5a9618dcc4080ed100486cedd0969e80fa4d
Authors: Porten, Klaudia; Rissland, Jürgen; Tigges, Almira; Broll, Susanne; Hopp, Wilfried; Lunemann, Mechthild; van Treeck, Ulrich; ... | What health regulations were changes due to the outbreak of C. burnetti? | 5,201 | forbid the display of sheep in the latter third of their pregnancy and require regular testing of animals for C. burnetii in petting zoos | 29,345 |
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