term
stringlengths
2
121
overlap
int64
6
281
setsize
int64
7
499
score
float64
1.96
10.6
pval
float64
0
0.05
edge
stringlengths
41
1.97k
type
stringclasses
5 values
subtype
stringclasses
24 values
subtype_key
stringclasses
24 values
edge_idxs
stringlengths
11
1.17k
ann_idxs
stringlengths
19
2.31k
ann_vals
stringlengths
124
9.94k
sig_size
int64
2.2k
3.73k
Peptidase complex
15
58
2.887445
0.003884
P54725,P28072,O00233,O00487,Q9UL46,P25789,P28074,P25788,P49721,P49720,Q9H490,Q99436,P20618,P60900,P28070
Localization
GO Cellular component
msigdb_gocc
166,34,132,188,206,350,106,349,18,142,184,394,59,378,62
515,874,132,188,1843,825,558,1050,929,1761,1445,59,1011,749,349,350,973,62,34,106,1893,1255,1115,1066,142,18,1894,1537,166,1928,2073,1895,378,937,1858,1257,1593,2528,537,1068,1416,1507,1638,943,1640,1212,1545,1219,1559,394,2091,914,184,206,415,922,2219,1615
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,0.6160723009781515,0.21377219628069816,0.3107081753546436,-0.31336929154874354,-0.058326639732175146,2.0274549169815406,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.4275222886859329,0.08028608865991266,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,-0.12957783544472734,1.2084658865131082,-0.46621885306434724,-0.624229536412293,-0.4275222886859329,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,-1.6802476075658623,0.6452247828693638,0.21377219628069816,-0.023187036139176026,-0.09379028637419248,-0.2021240853281833,0.3107081753546436,-0.2021240853281833,0.11412915938872559,-0.12957783544472734,0.11412915938872559,-0.12957783544472734,0.8153380062854007,-0.624229536412293,0.3424442560190503,1.15845820052481,1.107748671810519,0.7875391296424109,0.3424442560190503,-0.7873933421725157,-0.16568914771639728
2,631
Cis golgi network
7
12
2.883001
0.003939
O00461,Q8WVM8,P49755,O43731,Q14789,Q9NPR9,P24390
Localization
GO Cellular component
msigdb_gocc
187,343,143,54,86,362,123
187,54,1150,123,143,86,1459,1871,343,1276,362,416
1.13319242501366,2.0864437380032115,0.14765384784078572,1.3544699048423925,1.2822041225107923,1.5854529614565336,-0.058326639732175146,-0.3891484207838882,0.8702994873684097,0.08028608865991266,0.8429236851350608,0.7875391296424109
2,631
The role of gtse1 in g2 m progression after g2 checkpoint
12
49
2.879309
0.003985
P28072,O00233,O00487,Q9UL46,P25789,P28074,P25788,P49721,P49720,Q99436,P20618,P28070
Processes and pathways
Reactome Pathways
msigdb_reactome
34,132,188,206,350,106,349,18,142,394,59,62
515,874,132,188,1843,825,929,1196,1106,1107,2067,1717,1342,1445,59,1011,749,349,350,973,62,34,106,1893,1115,1066,142,18,1894,895,2073,378,937,1858,1257,1593,1068,1416,849,662,1507,943,632,394,2091,457,989,206,922
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,0.3107081753546436,0.11412915938872559,0.1808662269600239,0.1808662269600239,-0.624229536412293,-0.2759642918046235,0.011628382363652217,-0.058326639732175146,2.0274549169815406,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.4275222886859329,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,0.3424442560190503,-0.624229536412293,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.21377219628069816,-0.023187036139176026,0.3739010427175194,0.5271655315673739,-0.09379028637419248,0.3107081753546436,0.5570467687489573,0.8153380062854007,-0.624229536412293,0.7312880952006297,0.278687675691609,1.107748671810519,0.3424442560190503
2,631
Abc family proteins mediated transport
17
48
2.861794
0.004213
P28072,O00233,O00487,Q9UL46,P25789,P28074,Q9UBV2,P40855,P25788,P05198,P49721,P49720,Q99436,P28288,P20618,P60900,P28070
Processes and pathways
Reactome Pathways
msigdb_reactome
34,132,188,206,350,106,73,373,349,492,18,142,394,524,59,378,62
515,874,132,188,1843,825,1391,929,2247,492,622,1445,1059,59,1011,749,349,350,973,62,34,106,524,1893,373,1115,1066,142,18,1894,2073,1895,378,937,1858,1257,1593,1068,1416,1507,943,2575,394,2091,1429,73,206,922
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,-0.023187036139176026,0.3107081753546436,-0.8709052422195689,0.6741423628769925,0.5570467687489573,-0.058326639732175146,0.21377219628069816,2.0274549169815406,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,0.6452247828693638,-0.4275222886859329,0.8153380062854007,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,-0.624229536412293,-0.4275222886859329,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.21377219628069816,-0.023187036139176026,-0.09379028637419248,0.3107081753546436,-2.123764241801811,0.8153380062854007,-0.624229536412293,-0.023187036139176026,1.781481931571495,1.107748671810519,0.3424442560190503
2,631
Hedgehog off state
13
49
2.824366
0.004737
P28072,O00233,O00487,Q9UL46,P49841,P25789,P28074,P25788,P49721,P49720,Q99436,P20618,P28070
Processes and pathways
Reactome Pathways
msigdb_reactome
34,132,188,206,351,350,106,349,18,142,394,59,62
515,874,132,188,1843,825,929,1338,1295,1197,1445,59,1011,749,349,350,973,62,34,106,1893,1115,1066,527,142,18,351,1894,2073,378,937,1858,1257,1593,658,1068,1416,849,2361,662,1507,943,394,2091,457,989,206,922,2129
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,0.3107081753546436,0.011628382363652217,0.04611947228614343,0.11412915938872559,-0.058326639732175146,2.0274549169815406,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.4275222886859329,0.1808662269600239,0.21377219628069816,0.6452247828693638,1.2822041225107923,3.3458384043052356,0.8429236851350608,-0.4275222886859329,-0.624229536412293,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.5271655315673739,0.21377219628069816,-0.023187036139176026,0.3739010427175194,-1.085306619758222,0.5271655315673739,-0.09379028637419248,0.3107081753546436,0.8153380062854007,-0.624229536412293,0.7312880952006297,0.278687675691609,1.107748671810519,0.3424442560190503,-0.6645376888850335
2,631
Signaling by notch4
12
42
2.822767
0.004761
P28072,O00233,O00487,Q9UL46,P25789,P28074,P25788,P49721,P49720,Q99436,P20618,P28070
Processes and pathways
Reactome Pathways
msigdb_reactome
34,132,188,206,350,106,349,18,142,394,59,62
515,874,132,188,1843,825,929,1445,59,1011,749,349,350,973,62,34,106,1893,1115,1066,142,18,1894,2073,378,937,1858,1257,1593,568,658,1068,1416,2185,2361,943,910,394,2091,206,922,737
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,0.3107081753546436,-0.058326639732175146,2.0274549169815406,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.4275222886859329,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,-0.624229536412293,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.6160723009781515,0.5271655315673739,0.21377219628069816,-0.023187036139176026,-0.7461197124067016,-1.085306619758222,0.3107081753546436,0.3424442560190503,0.8153380062854007,-0.624229536412293,1.107748671810519,0.3424442560190503,0.46664484400905687
2,631
Threonine type peptidase activity
7
9
2.806457
0.005009
P28072,P25789,P28074,P49721,P49720,P20618,P28070
Functions
GO Molecular function
msigdb_gomf
34,350,106,18,142,59,62
59,350,62,34,106,142,18,1550,394
2.0274549169815406,0.8429236851350608,2.007578507508111,2.561425042425346,1.47179933358734,1.2822041225107923,3.3458384043052356,-0.12957783544472734,0.8153380062854007
2,631
Apc c mediated degradation of cell cycle proteins
16
55
2.77273
0.005559
P28072,O00233,Q9UJX6,O00487,Q9UL46,O43684,P25789,P28074,P25788,Q9UJX3,Q13309,P49721,P49720,Q99436,P20618,P28070
Processes and pathways
Reactome Pathways
msigdb_reactome
34,132,273,188,206,308,350,106,349,126,294,18,142,394,59,62
515,874,132,188,1843,825,308,929,1107,1342,1445,59,833,1011,749,349,350,973,62,34,106,1200,1893,1115,1066,142,18,1894,895,2073,378,937,1858,1257,1593,658,1068,2506,1416,294,2361,1507,943,1544,815,2019,394,2091,731,2555,126,674,273,206,922
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,0.8974686565746289,0.3107081753546436,0.1808662269600239,0.011628382363652217,-0.058326639732175146,2.0274549169815406,0.3739010427175194,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,0.11412915938872559,-0.4275222886859329,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,0.3424442560190503,-0.624229536412293,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.5271655315673739,0.21377219628069816,-1.538154279489105,-0.023187036139176026,0.9244343611620436,-1.085306619758222,-0.09379028637419248,0.3107081753546436,-0.12957783544472734,0.40508352216113896,-0.544579561175527,0.8153380062854007,-0.624229536412293,0.46664484400905687,-1.9234564142985089,1.3544699048423925,0.5271655315673739,0.977767688006064,1.107748671810519,0.3424442560190503
2,631
Transport to the golgi and subsequent modification
24
68
2.769306
0.005618
Q92734,Q15363,P49755,P83436,Q9UBF2,P04066,P54920,Q13561,Q12907,Q9Y3B3,P18085,O43731,Q9BUF5,Q15436,Q8WVM8,O75935,Q9Y6B6,Q14789,O15498,Q9Y678,Q9BVK6,P49257,P62820,P24390
Processes and pathways
Reactome Pathways
msigdb_reactome
546,5,143,282,555,150,292,423,422,53,179,54,457,61,343,75,82,86,328,230,102,234,500,123
2438,788,328,2331,54,1803,1758,75,1244,1150,2101,150,179,123,2202,1254,1675,1064,1500,234,143,1536,1205,2141,1354,1678,292,1162,797,500,1778,282,2179,422,1784,2205,849,423,2362,662,1684,2402,86,5,61,1459,576,2289,1509,1828,343,1276,546,1981,2211,693,457,989,102,1795,555,1324,821,53,230,82,2521,1045
-1.307727538673511,0.40508352216113896,0.8702994873684097,-1.041784332284214,2.0864437380032115,-0.3510973783434665,-0.31336929154874354,1.7173052362630885,0.08028608865991266,0.14765384784078572,-0.6645376888850335,1.257791335055367,1.15845820052481,1.3544699048423925,-0.7873933421725157,0.08028608865991266,-0.23888251175943867,0.21377219628069816,-0.09379028637419248,1.0303233973076291,1.2822041225107923,-0.12957783544472734,0.11412915938872559,-0.705167787937405,0.011628382363652217,-0.23888251175943867,0.9244343611620436,0.14765384784078572,0.40508352216113896,0.6741423628769925,-0.31336929154874354,0.9511996966722966,-0.7461197124067016,0.759523653936807,-0.31336929154874354,-0.7873933421725157,0.3739010427175194,0.759523653936807,-1.085306619758222,0.5271655315673739,-0.23888251175943867,-1.17331342279577,1.5854529614565336,4.86328444949437,2.0274549169815406,-0.058326639732175146,0.6160723009781515,-0.9557025473106139,-0.09379028637419248,-0.3510973783434665,0.8702994873684097,0.08028608865991266,0.6452247828693638,-0.5052379861113006,-0.7873933421725157,0.49703301170235065,0.7312880952006297,0.278687675691609,1.4948164960337653,-0.31336929154874354,0.6452247828693638,0.04611947228614343,0.40508352216113896,2.1058970915870394,1.0563168307418604,1.6299370577151888,-1.5851991561112928,0.24637748849157123
2,631
Threonine type endopeptidase activity
7
8
2.754227
0.005883
P28072,P25789,P28074,P49721,P49720,P20618,P28070
Functions
GO Molecular function
msigdb_gomf
34,350,106,18,142,59,62
59,350,62,34,106,142,18,394
2.0274549169815406,0.8429236851350608,2.007578507508111,2.561425042425346,1.47179933358734,1.2822041225107923,3.3458384043052356,0.8153380062854007
2,631
Proteasome beta-type subunit, conserved site [IPR016050]
7
8
2.754227
0.005883
P28072,P25789,P28074,P49721,P49720,P20618,P28070
Sequence
InterPro Conserved site
interpro_conserved_site
34,350,106,18,142,59,62
59,350,62,34,106,142,18,394
2.0274549169815406,0.8429236851350608,2.007578507508111,2.561425042425346,1.47179933358734,1.2822041225107923,3.3458384043052356,0.8153380062854007
2,631
Tclin
23
74
2.726369
0.006404
Q99720,P00491,P00374,O43676,P48735,P49721,P31350,P0DP25,P11802,O43924,O96000,O95168,Q9BUF5,P20618,P62942,Q16718,Q99808,Q06203,Q9Y2I1,O75306,P49841,P28074,O43674
Drugs and Diseases
Pharos IDG Category
pharos_protein_category
0,368,9,262,17,18,152,151,279,396,275,289,457,59,60,450,74,447,228,219,351,106,119
966,119,262,396,466,219,1194,289,2031,1151,275,9,930,368,2426,1993,2286,2622,621,2066,880,881,2524,2287,1763,151,1248,1057,2453,2168,279,1010,883,2198,1578,59,684,1157,832,1011,1496,106,714,1014,152,2041,1534,17,18,351,655,1630,2142,60,1261,447,1597,849,662,450,1689,575,1937,1602,1129,0,74,1133,457,989,2265,1094,228,1664
0.278687675691609,1.3782415831495038,0.977767688006064,0.7875391296424109,0.7028288840536002,1.0563168307418604,0.11412915938872559,0.9244343611620436,-0.5842434527420278,0.14765384784078572,0.9511996966722966,4.004804150480747,0.3107081753546436,0.8153380062854007,-1.26260245787533,-0.544579561175527,-0.9557025473106139,-4.155175979385143,0.5570467687489573,-0.624229536412293,0.3424442560190503,0.3424442560190503,-1.6325636329473232,-0.9557025473106139,-0.31336929154874354,1.257791335055367,0.08028608865991266,0.21377219628069816,-1.3531728506809722,-0.7461197124067016,0.9511996966722966,0.24637748849157123,0.3424442560190503,-0.7873933421725157,-0.16568914771639728,2.0274549169815406,0.49703301170235065,0.14765384784078572,0.3739010427175194,0.24637748849157123,-0.09379028637419248,1.47179933358734,0.46664484400905687,0.24637748849157123,1.257791335055367,-0.5842434527420278,-0.12957783544472734,3.521809624851483,3.3458384043052356,0.8429236851350608,0.5271655315673739,-0.2021240853281833,-0.705167787937405,2.0274549169815406,0.08028608865991266,0.7312880952006297,-0.16568914771639728,0.3739010427175194,0.5271655315673739,0.7312880952006297,-0.23888251175943867,0.6160723009781515,-0.46621885306434724,-0.16568914771639728,0.1808662269600239,5.562677407182912,1.7602151237227783,0.1808662269600239,0.7312880952006297,0.278687675691609,-0.8709052422195689,0.21377219628069816,1.0563168307418604,-0.2021240853281833
2,631
Cellular iron ion homeostasis
6
12
2.719104
0.006546
P61421,P30626,Q15904,P02786,Q9Y487,Q8N511
Processes and pathways
GO Biological process
msigdb_gobp
167,163,145,264,260,121
1391,1530,264,311,1446,163,597,167,145,121,917,260
-0.023187036139176026,-0.12957783544472734,0.977767688006064,0.8974686565746289,-0.058326639732175146,1.2084658865131082,0.5866809767008758,1.2084658865131082,1.2822041225107923,1.3782415831495038,0.3424442560190503,1.0041412915640857
2,631
Metallopeptidase activity
22
41
2.712459
0.006679
P42892,Q9UIQ6,Q92905,Q99797,P02786,Q9H4A4,P55786,Q969V3,Q9HD42,P50579,Q7L5N1,Q9NZ08,Q9BYT8,Q10713,Q5JRX3,O00487,O75439,P16870,O00303,P52888,Q7Z2K6,P36551
Functions
GO Molecular function
msigdb_gomf
245,4,269,409,264,550,33,429,699,174,689,55,325,687,66,188,706,208,588,97,504,233
588,188,740,1489,706,1335,708,264,1889,1921,1850,208,831,2396,233,245,174,1894,97,33,2494,687,66,2016,689,504,269,429,860,2057,409,817,325,550,699,1234,1186,1092,55,4,2219
0.5866809767008758,1.13319242501366,0.4359965476908903,-0.09379028637419248,0.46664484400905687,0.011628382363652217,0.46664484400905687,0.977767688006064,-0.4275222886859329,-0.46621885306434724,-0.3891484207838882,1.0821243548255537,0.3739010427175194,-1.17331342279577,1.0303233973076291,1.0041412915640857,1.183548528852841,-0.4275222886859329,1.4948164960337653,2.679467443709186,-1.4914291062743523,0.49703301170235065,1.865329260145266,-0.544579561175527,0.49703301170235065,0.6741423628769925,0.977767688006064,0.759523653936807,0.3739010427175194,-0.5842434527420278,0.7875391296424109,0.40508352216113896,0.8974686565746289,0.6452247828693638,0.49703301170235065,0.11412915938872559,0.14765384784078572,0.21377219628069816,2.0864437380032115,4.954689535317153,-0.7873933421725157
2,631
Copi dependent golgi to er retrograde traffic
13
42
2.710553
0.006717
Q15363,Q9BVK6,P54920,P49755,P52732,Q9Y3B3,P18085,O43731,P62820,Q9BUF5,Q9Y678,P24390,O43264
Processes and pathways
Reactome Pathways
msigdb_reactome
5,102,292,143,235,53,179,54,500,457,230,123,395
1916,1567,395,54,1758,1395,179,123,2071,1254,1675,1500,143,235,1205,2141,292,797,500,2276,1121,847,801,849,662,2234,5,1547,1828,1276,1087,693,457,989,102,1562,1322,1188,555,53,2129,230
-0.46621885306434724,-0.16568914771639728,0.7875391296424109,2.0864437380032115,-0.31336929154874354,-0.023187036139176026,1.15845820052481,1.3544699048423925,-0.624229536412293,0.08028608865991266,-0.23888251175943867,-0.09379028637419248,1.2822041225107923,1.0303233973076291,0.11412915938872559,-0.705167787937405,0.9244343611620436,0.40508352216113896,0.6741423628769925,-0.9131432773169984,0.1808662269600239,0.3739010427175194,0.40508352216113896,0.3739010427175194,0.5271655315673739,-0.8289885581393346,4.86328444949437,-0.12957783544472734,-0.3510973783434665,0.08028608865991266,0.21377219628069816,0.49703301170235065,0.7312880952006297,0.278687675691609,1.4948164960337653,-0.12957783544472734,0.04611947228614343,0.14765384784078572,0.6452247828693638,2.1058970915870394,-0.6645376888850335,1.0563168307418604
2,631
Metalloprotease
9
27
2.686426
0.007222
P55786,P42892,Q5JRX3,Q9UIQ6,O00487,P52888,Q92905,Q9NZ08,P16870
Functions
Protein Atlas Molecular function
protein_atlas_molecular_function
33,245,66,4,188,97,269,55,208
188,1489,706,1335,708,1889,1921,1850,208,245,97,33,2494,66,504,269,860,2057,409,325,550,1234,1186,1092,55,4,2219
1.13319242501366,-0.09379028637419248,0.46664484400905687,0.011628382363652217,0.46664484400905687,-0.4275222886859329,-0.46621885306434724,-0.3891484207838882,1.0821243548255537,1.0041412915640857,1.4948164960337653,2.679467443709186,-1.4914291062743523,1.865329260145266,0.6741423628769925,0.977767688006064,0.3739010427175194,-0.5842434527420278,0.7875391296424109,0.8974686565746289,0.6452247828693638,0.11412915938872559,0.14765384784078572,0.21377219628069816,2.0864437380032115,4.954689535317153,-0.7873933421725157
2,631
SLC superfamily of solute carriers
7
32
2.684251
0.007269
O43772,Q99808,Q70HW3,Q9Y619,P41440,Q9UBX3,Q8IXU6
Drugs and Diseases
Pharos Drug Target Ontology
pharos_dto
3,74,12,47,49,84,21
3,1571,1573,2132,1805,2249,1108,1920,1340,49,2427,2142,2381,2180,2483,946,1423,12,21,813,302,74,2295,130,1833,2298,1478,84,1565,586,47,2557
4.963710030498427,-0.16568914771639728,-0.16568914771639728,-0.705167787937405,-0.3510973783434665,-0.8709052422195689,0.1808662269600239,-0.46621885306434724,0.011628382363652217,2.2016422601947694,-1.26260245787533,-0.705167787937405,-1.129149687086767,-0.7461197124067016,-1.445023740434061,0.3107081753546436,-0.023187036139176026,3.6898423487511414,3.2189420102262942,0.40508352216113896,0.9244343611620436,1.7602151237227783,-0.9557025473106139,1.330541201726474,-0.3510973783434665,-0.9557025473106139,-0.058326639732175146,1.6077630652259416,-0.12957783544472734,0.6160723009781515,2.2204944858377984,-1.9234564142985089
2,631
Endoplasmic reticulum to golgi vesicle mediated transport
25
65
2.67772
0.007413
Q92734,Q15363,P49755,Q9NR31,Q9Y3A6,Q15437,Q9Y282,O43264,Q12907,Q9Y3B3,P18085,O43731,Q9HD26,Q15436,Q8WVM8,Q9Y6B6,O15498,Q9Y678,Q9BVK6,O95070,Q9UHY1,P49257,Q96RQ1,P62820,P24390
Processes and pathways
GO Biological process
msigdb_gobp
546,5,143,412,416,22,29,395,422,53,179,54,459,61,343,82,328,230,102,105,514,234,393,500,123
2438,788,328,395,54,1803,2566,1758,1244,105,1150,2134,2101,179,123,1254,1500,234,143,2466,1819,1205,2141,1678,1895,1411,500,422,1784,2112,5,61,22,2289,1547,1868,1509,2084,343,1276,546,1466,2211,393,102,1912,1795,459,2554,412,1322,2434,1188,555,1380,514,29,821,2578,416,53,2532,230,82,1045
-1.307727538673511,0.40508352216113896,0.8702994873684097,0.7875391296424109,2.0864437380032115,-0.3510973783434665,-2.022972918699234,-0.31336929154874354,0.08028608865991266,1.47179933358734,0.14765384784078572,-0.705167787937405,-0.6645376888850335,1.15845820052481,1.3544699048423925,0.08028608865991266,-0.09379028637419248,1.0303233973076291,1.2822041225107923,-1.3989382867201257,-0.3510973783434665,0.11412915938872559,-0.705167787937405,-0.23888251175943867,-0.4275222886859329,-0.023187036139176026,0.6741423628769925,0.759523653936807,-0.31336929154874354,-0.6645376888850335,4.86328444949437,2.0274549169815406,3.1756606722953644,-0.9557025473106139,-0.12957783544472734,-0.3891484207838882,-0.09379028637419248,-0.624229536412293,0.8702994873684097,0.08028608865991266,0.6452247828693638,-0.058326639732175146,-0.7873933421725157,0.8153380062854007,1.4948164960337653,-0.4275222886859329,-0.31336929154874354,0.7312880952006297,-1.9234564142985089,0.7875391296424109,0.04611947228614343,-1.26260245787533,0.14765384784078572,0.6452247828693638,0.011628382363652217,0.6741423628769925,2.841800548164946,0.40508352216113896,-2.123764241801811,0.7875391296424109,2.1058970915870394,-1.6802476075658623,1.0563168307418604,1.6299370577151888,0.24637748849157123
2,631
Intracellular signaling by second messengers
23
73
2.675822
0.007455
O00233,P49721,P49720,O00231,P30153,P28072,P52292,P27361,O43865,P20618,P28070,O00487,Q9UL46,P62993,Q6IAA8,Q9Y2Q5,P49841,P25789,P28074,P25788,Q99436,Q96B36,P60900
Processes and pathways
Reactome Pathways
msigdb_reactome
132,18,142,515,280,34,420,419,177,59,62,188,206,210,477,96,351,350,106,349,394,254,378
515,874,132,188,1843,825,177,517,929,2451,879,1106,1338,1295,1197,1445,885,59,1011,749,349,350,419,973,62,34,106,1721,280,835,1893,1534,1115,1066,142,18,351,1894,420,2073,378,937,1858,1257,1593,210,2109,1208,1307,1068,1416,1360,1506,2482,1507,943,1418,1122,477,2209,770,2498,1129,814,254,394,2091,698,2488,206,820,922,96
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,1.15845820052481,0.6452247828693638,0.3107081753546436,-1.3531728506809722,0.3424442560190503,0.1808662269600239,0.011628382363652217,0.04611947228614343,0.11412915938872559,-0.058326639732175146,0.3424442560190503,2.0274549169815406,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.759523653936807,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.2759642918046235,0.9511996966722966,0.3739010427175194,-0.4275222886859329,-0.12957783544472734,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,0.8429236851350608,-0.4275222886859329,0.759523653936807,-0.624229536412293,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,1.0821243548255537,-0.6645376888850335,0.11412915938872559,0.04611947228614343,0.21377219628069816,-0.023187036139176026,0.011628382363652217,-0.09379028637419248,-1.445023740434061,-0.09379028637419248,0.3107081753546436,-0.023187036139176026,0.1808662269600239,0.7028288840536002,-0.7873933421725157,0.4359965476908903,-1.4914291062743523,0.1808662269600239,0.40508352216113896,1.0041412915640857,0.8153380062854007,-0.624229536412293,0.49703301170235065,-1.445023740434061,1.107748671810519,0.40508352216113896,0.3424442560190503,1.5176885982704214
2,631
Er to golgi anterograde transport
23
65
2.665637
0.007684
Q92734,Q15363,P49755,P83436,Q9UBF2,P54920,Q13561,Q12907,Q9Y3B3,P18085,O43731,Q9BUF5,Q15436,Q8WVM8,O75935,Q9Y6B6,Q14789,O15498,Q9Y678,Q9BVK6,P49257,P62820,P24390
Processes and pathways
Reactome Pathways
msigdb_reactome
546,5,143,282,555,292,423,422,53,179,54,457,61,343,75,82,86,328,230,102,234,500,123
2438,788,328,2331,54,1803,1758,75,1244,1150,2101,179,123,1254,1675,1064,1500,234,143,1536,1205,2141,1354,1678,292,1162,797,500,1778,282,2179,422,1784,2205,849,423,2362,662,1684,2402,86,5,61,576,2289,1509,1828,343,1276,546,1981,2211,693,457,989,102,1795,555,1324,821,53,230,82,2521,1045
-1.307727538673511,0.40508352216113896,0.8702994873684097,-1.041784332284214,2.0864437380032115,-0.3510973783434665,-0.31336929154874354,1.7173052362630885,0.08028608865991266,0.14765384784078572,-0.6645376888850335,1.15845820052481,1.3544699048423925,0.08028608865991266,-0.23888251175943867,0.21377219628069816,-0.09379028637419248,1.0303233973076291,1.2822041225107923,-0.12957783544472734,0.11412915938872559,-0.705167787937405,0.011628382363652217,-0.23888251175943867,0.9244343611620436,0.14765384784078572,0.40508352216113896,0.6741423628769925,-0.31336929154874354,0.9511996966722966,-0.7461197124067016,0.759523653936807,-0.31336929154874354,-0.7873933421725157,0.3739010427175194,0.759523653936807,-1.085306619758222,0.5271655315673739,-0.23888251175943867,-1.17331342279577,1.5854529614565336,4.86328444949437,2.0274549169815406,0.6160723009781515,-0.9557025473106139,-0.09379028637419248,-0.3510973783434665,0.8702994873684097,0.08028608865991266,0.6452247828693638,-0.5052379861113006,-0.7873933421725157,0.49703301170235065,0.7312880952006297,0.278687675691609,1.4948164960337653,-0.31336929154874354,0.6452247828693638,0.04611947228614343,0.40508352216113896,2.1058970915870394,1.0563168307418604,1.6299370577151888,-1.5851991561112928,0.24637748849157123
2,631
Dermatological manifestations of systemic disorders
14
61
2.662034
0.007767
P35914,O43772,Q9UJX6,P51812,P00374,P40855,Q15904,P04066,P36551,P83436,Q15437,Q9Y3Z3,P35670,O14936
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
223,3,273,376,9,373,145,150,233,282,22,87,398,149
1916,149,2165,3,1952,592,928,1335,440,9,1492,1847,150,1397,1106,1153,971,1338,1108,1890,1623,1921,1154,1718,524,398,223,233,1853,373,837,891,1351,934,376,2072,2428,2044,1631,282,1965,1539,2381,2179,761,1365,22,145,944,1547,1370,2190,2087,1427,1228,1183,1798,1565,273,87,1001
-0.46621885306434724,1.257791335055367,-0.7461197124067016,4.963710030498427,-0.5052379861113006,0.5866809767008758,0.3107081753546436,0.011628382363652217,0.7312880952006297,4.004804150480747,-0.09379028637419248,-0.3891484207838882,1.257791335055367,-0.023187036139176026,0.1808662269600239,0.14765384784078572,0.278687675691609,0.011628382363652217,0.1808662269600239,-0.4275222886859329,-0.2021240853281833,-0.46621885306434724,0.14765384784078572,-0.2759642918046235,0.6452247828693638,0.7875391296424109,1.0563168307418604,1.0303233973076291,-0.3891484207838882,0.8153380062854007,0.3739010427175194,0.3424442560190503,0.011628382363652217,0.3107081753546436,0.8153380062854007,-0.624229536412293,-1.26260245787533,-0.5842434527420278,-0.2021240853281833,0.9511996966722966,-0.5052379861113006,-0.12957783544472734,-1.129149687086767,-0.7461197124067016,0.4359965476908903,0.011628382363652217,3.1756606722953644,1.2822041225107923,0.3107081753546436,-0.12957783544472734,0.011628382363652217,-0.7461197124067016,-0.624229536412293,-0.023187036139176026,0.11412915938872559,0.14765384784078572,-0.31336929154874354,-0.12957783544472734,0.977767688006064,1.5854529614565336,0.278687675691609
2,631
Outer membrane
29
70
2.642743
0.008224
Q99720,Q13505,Q15388,Q92667,P45880,Q9NQZ5,Q9UBM7,O75431,Q7Z434,Q9NS69,O00264,Q8N4H5,P09601,P50416,P50402,Q6UXV4,Q9Y277,Q9Y512,Q9NZ45,O43169,O00763,Q9GZY8,P21796,P30536,Q8IXI2,Q8N0X7,O00429,Q16611,Q5XKP0
Localization
GO Cellular component
msigdb_gocc
0,661,540,545,267,288,23,645,690,185,556,194,311,444,565,342,735,346,732,329,704,613,85,715,769,388,108,112,503
1436,556,108,704,329,1052,1990,645,1149,1715,1104,1492,2224,1056,311,1718,85,715,1298,2288,1534,1626,267,565,444,1590,1679,1412,1069,661,1687,540,2150,112,1904,983,503,342,690,1079,1372,769,388,194,1737,1738,2117,2367,545,1830,1223,0,1703,1746,1657,613,1477,288,185,1611,818,732,1478,997,23,781,735,962,346,2557
-0.058326639732175146,0.6160723009781515,1.4486352146024881,0.46664484400905687,0.8702994873684097,0.21377219628069816,-0.544579561175527,0.5271655315673739,0.14765384784078572,-0.2759642918046235,0.1808662269600239,-0.09379028637419248,-0.8289885581393346,0.21377219628069816,0.8974686565746289,-0.2759642918046235,1.5854529614565336,0.46664484400905687,0.04611947228614343,-0.9557025473106139,-0.12957783544472734,-0.2021240853281833,0.977767688006064,0.6160723009781515,0.7312880952006297,-0.16568914771639728,-0.23888251175943867,-0.023187036139176026,0.21377219628069816,0.5271655315673739,-0.23888251175943867,0.6452247828693638,-0.705167787937405,1.4253222050252763,-0.4275222886859329,0.278687675691609,0.6741423628769925,0.8702994873684097,0.49703301170235065,0.21377219628069816,0.011628382363652217,0.4359965476908903,0.8153380062854007,1.13319242501366,-0.2759642918046235,-0.2759642918046235,-0.6645376888850335,-1.085306619758222,0.6452247828693638,-0.3510973783434665,0.11412915938872559,5.562677407182912,-0.23888251175943867,-0.2759642918046235,-0.2021240853281833,0.5866809767008758,-0.058326639732175146,0.9511996966722966,1.15845820052481,-0.16568914771639728,0.40508352216113896,0.46664484400905687,-0.058326639732175146,0.278687675691609,3.102383344071522,0.4359965476908903,0.46664484400905687,0.3107081753546436,0.8702994873684097,-1.9234564142985089
2,631
Sphingolipid metabolic process
6
23
2.637859
0.008343
P50897,Q06136,Q99805,P06865,Q8NCC3,P30153
Processes and pathways
GO Biological process
msigdb_gobp
314,2,26,276,27,280
1711,1050,791,1848,880,276,310,2032,1399,563,280,314,2,1824,983,27,2119,26,1181,1432,1478,1835,2434
-0.2759642918046235,0.21377219628069816,0.40508352216113896,-0.3891484207838882,0.3424442560190503,0.9511996966722966,0.8974686565746289,-0.5842434527420278,-0.023187036139176026,0.6160723009781515,0.9511996966722966,0.8974686565746289,5.1051968387484905,-0.3510973783434665,0.278687675691609,2.9358813459906243,-0.6645376888850335,3.0124937225901696,0.14765384784078572,-0.023187036139176026,-0.058326639732175146,-0.3510973783434665,-1.26260245787533
2,631
Er to golgi transport vesicle membrane
8
21
2.631247
0.008507
Q15363,P10321,P49755,P49257,Q9Y6B6,Q9Y3B3,Q15437,Q15436
Localization
GO Cellular component
msigdb_gocc
5,347,143,234,82,53,22,61
788,1803,2566,1758,1244,2101,793,347,234,143,1678,1784,5,61,22,1788,412,1380,53,82,1045
0.40508352216113896,-0.3510973783434665,-2.022972918699234,-0.31336929154874354,0.08028608865991266,-0.6645376888850335,0.40508352216113896,0.8429236851350608,1.0303233973076291,1.2822041225107923,-0.23888251175943867,-0.31336929154874354,4.86328444949437,2.0274549169815406,3.1756606722953644,-0.31336929154874354,0.7875391296424109,0.011628382363652217,2.1058970915870394,1.6299370577151888,0.24637748849157123
2,631
Ectrodactyly
7
14
2.630432
0.008528
Q99720,Q13363,P48449,O96028,Q9H3P2,Q9UBM7,Q9NR77
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
0,295,8,140,287,23,258
2132,140,1761,8,1676,295,1420,341,2117,0,287,258,2551,23
-0.705167787937405,1.2822041225107923,-0.31336929154874354,4.016404489026196,-0.23888251175943867,0.9244343611620436,-0.023187036139176026,0.8702994873684097,-0.6645376888850335,5.562677407182912,0.9511996966722966,1.0041412915640857,-1.874176461311327,3.102383344071522
2,631
Organic hydroxy compound metabolic process
30
89
2.5796
0.009891
Q9BY49,P09417,P48449,P00374,Q8WTV0,P48735,Q9NZJ6,P58546,Q9UBM7,Q13572,P28288,Q15392,O75874,Q9BQE5,P00492,P30837,P21964,P53602,Q8TC12,O60762,Q16850,Q96SU4,O75845,O00764,P11766,P61457,Q14534,Q9BW91,O14734,P05091
Processes and pathways
GO Biological process
msigdb_gobp
129,369,8,9,10,17,554,657,23,405,524,36,41,44,681,56,684,686,451,190,202,483,332,589,596,600,381,638,489,621
1239,589,489,1048,2165,1711,2267,190,1573,332,41,878,2247,1440,1441,9,1492,681,1848,1106,621,1292,369,1623,596,883,747,2198,830,1343,1344,684,1158,1345,524,56,2339,1583,1771,2041,1773,1349,8,17,1351,1535,934,935,1629,686,657,2044,600,1631,2357,2046,1120,687,1824,405,1023,381,1365,2207,36,804,202,986,451,10,1653,2056,483,1911,1279,1427,2346,44,638,129,1181,1476,1477,554,23,1749,999,2461,1001
0.08028608865991266,0.5866809767008758,0.6741423628769925,0.21377219628069816,-0.7461197124067016,-0.2759642918046235,-0.9131432773169984,1.13319242501366,-0.16568914771639728,0.8702994873684097,2.4038695750039927,0.3424442560190503,-0.8709052422195689,-0.058326639732175146,-0.058326639732175146,4.004804150480747,-0.09379028637419248,0.49703301170235065,-0.3891484207838882,0.1808662269600239,0.5570467687489573,0.04611947228614343,0.8153380062854007,-0.2021240853281833,0.5866809767008758,0.3424442560190503,0.4359965476908903,-0.7873933421725157,0.3739010427175194,0.011628382363652217,0.011628382363652217,0.49703301170235065,0.14765384784078572,0.011628382363652217,0.6452247828693638,2.06688635784378,-1.041784332284214,-0.16568914771639728,-0.31336929154874354,-0.5842434527420278,-0.31336929154874354,0.011628382363652217,4.016404489026196,3.521809624851483,0.011628382363652217,-0.12957783544472734,0.3107081753546436,0.3107081753546436,-0.2021240853281833,0.49703301170235065,0.5271655315673739,-0.5842434527420278,0.5866809767008758,-0.2021240853281833,-1.085306619758222,-0.5842434527420278,0.1808662269600239,0.49703301170235065,-0.3510973783434665,0.7875391296424109,0.24637748849157123,0.8153380062854007,0.011628382363652217,-0.7873933421725157,2.5096531511230316,0.40508352216113896,1.107748671810519,0.278687675691609,0.7312880952006297,3.9225804558905155,-0.2021240853281833,-0.5842434527420278,0.7028288840536002,-0.4275222886859329,0.08028608865991266,-0.023187036139176026,-1.041784332284214,2.3498130031826134,0.5570467687489573,1.330541201726474,0.14765384784078572,-0.058326639732175146,-0.058326639732175146,0.6452247828693638,3.102383344071522,-0.2759642918046235,0.278687675691609,-1.3531728506809722,0.278687675691609
2,631
Metabolism of water soluble vitamins and cofactors
9
29
2.578933
0.009911
Q9BQG2,Q9H2D1,Q9NRN7,Q99707,P00374,P78417,P41440,Q9NVE7,P34897
Processes and pathways
Reactome Pathways
msigdb_reactome
64,130,131,169,9,236,49,186,371
704,589,9,1492,561,1108,713,1849,1341,1297,371,49,374,893,2008,236,2149,1548,948,1127,1980,1035,169,64,130,2059,131,186,586
0.46664484400905687,0.5866809767008758,4.004804150480747,-0.09379028637419248,0.6160723009781515,0.1808662269600239,0.46664484400905687,-0.3891484207838882,0.011628382363652217,0.04611947228614343,0.8153380062854007,2.2016422601947694,0.8153380062854007,0.3424442560190503,-0.544579561175527,1.0303233973076291,-0.705167787937405,-0.12957783544472734,0.3107081753546436,0.1808662269600239,-0.5052379861113006,0.24637748849157123,1.2084658865131082,1.9674982888411903,1.330541201726474,-0.5842434527420278,1.330541201726474,1.15845820052481,0.6160723009781515
2,631
Macromolecule transmembrane transporter activity
7
12
2.576008
0.009995
O14925,Q15388,P49755,Q9NS69,P51991,Q99595,O60830
Functions
GO Molecular function
msigdb_gomf
438,540,143,185,209,115,231
438,231,1149,1104,143,209,533,1069,540,115,185,1381
0.7312880952006297,1.0303233973076291,0.14765384784078572,0.1808662269600239,1.2822041225107923,1.0821243548255537,0.6452247828693638,0.21377219628069816,0.6452247828693638,1.4018583320651603,1.15845820052481,0.011628382363652217
2,631
Copi mediated anterograde transport
16
45
2.570133
0.010166
P24390,Q15363,Q9BVK6,P54920,O75935,Q13561,P49755,P83436,Q9Y3B3,P18085,O43731,Q14789,P62820,Q9BUF5,Q9Y678,O15498
Processes and pathways
Reactome Pathways
msigdb_reactome
123,5,102,292,75,423,143,282,53,179,54,86,500,457,230,328
328,2331,54,1803,75,1150,179,123,1254,1675,1064,1500,143,1536,1205,2141,292,1162,797,500,1778,282,2179,1784,2205,849,423,2362,662,1684,2402,86,5,1828,1276,1981,693,457,989,102,555,1324,53,230,2521
0.8702994873684097,-1.041784332284214,2.0864437380032115,-0.3510973783434665,1.7173052362630885,0.14765384784078572,1.15845820052481,1.3544699048423925,0.08028608865991266,-0.23888251175943867,0.21377219628069816,-0.09379028637419248,1.2822041225107923,-0.12957783544472734,0.11412915938872559,-0.705167787937405,0.9244343611620436,0.14765384784078572,0.40508352216113896,0.6741423628769925,-0.31336929154874354,0.9511996966722966,-0.7461197124067016,-0.31336929154874354,-0.7873933421725157,0.3739010427175194,0.759523653936807,-1.085306619758222,0.5271655315673739,-0.23888251175943867,-1.17331342279577,1.5854529614565336,4.86328444949437,-0.3510973783434665,0.08028608865991266,-0.5052379861113006,0.49703301170235065,0.7312880952006297,0.278687675691609,1.4948164960337653,0.6452247828693638,0.04611947228614343,2.1058970915870394,1.0563168307418604,-1.5851991561112928
2,631
G2 m checkpoints
17
76
2.546669
0.010876
P28072,O00233,O00487,Q9UL46,P25789,P28074,P25788,Q99436,Q9UQ84,Q9Y619,O96028,P49721,P49720,P40938,P20618,Q9NXR7,P28070
Processes and pathways
Reactome Pathways
msigdb_reactome
34,132,188,206,350,106,349,394,15,47,140,18,142,180,59,363,62
515,874,132,188,1843,825,1053,929,1196,140,1106,1107,1342,884,2199,1445,59,833,1813,1011,749,349,350,888,628,973,62,34,106,1253,1673,1201,1347,496,2171,1348,1893,629,180,1115,1066,142,18,1589,1352,753,1894,2073,378,1304,937,1413,1858,1257,720,1593,1728,568,800,1068,1900,1416,1903,2616,1507,943,2458,394,2091,1560,2542,363,206,922,15,47
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,0.21377219628069816,0.3107081753546436,0.11412915938872559,1.2822041225107923,0.1808662269600239,0.1808662269600239,0.011628382363652217,0.3424442560190503,-0.7873933421725157,-0.058326639732175146,2.0274549169815406,0.3739010427175194,-0.3510973783434665,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.3424442560190503,0.5570467687489573,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,0.08028608865991266,-0.23888251175943867,0.11412915938872559,0.011628382363652217,0.6741423628769925,-0.7461197124067016,0.011628382363652217,-0.4275222886859329,0.5570467687489573,1.15845820052481,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.16568914771639728,0.011628382363652217,0.4359965476908903,-0.4275222886859329,-0.624229536412293,0.8153380062854007,0.04611947228614343,0.3107081753546436,-0.023187036139176026,-0.3891484207838882,0.08028608865991266,0.46664484400905687,-0.16568914771639728,-0.2759642918046235,0.6160723009781515,0.40508352216113896,0.21377219628069816,-0.4275222886859329,-0.023187036139176026,-0.4275222886859329,-3.316394992471545,-0.09379028637419248,0.3107081753546436,-1.3531728506809722,0.8153380062854007,-0.624229536412293,-0.12957783544472734,-1.7765736441710231,0.8429236851350608,1.107748671810519,0.3424442560190503,3.5612639181654293,2.2204944858377984
2,631
metalloprotease
10
25
2.545464
0.010913
P55786,P42892,Q5JRX3,Q9UIQ6,P52888,Q7Z2K6,Q99797,P02786,Q9NZ08,Q9BYT8
Functions
Panther Protein class
panther_protein_class
33,245,66,4,97,504,409,264,55,325
1489,706,1335,264,1921,1850,831,2396,1924,245,97,33,687,66,504,505,860,2057,409,325,1234,1092,55,4,2219
-0.09379028637419248,0.46664484400905687,0.011628382363652217,0.977767688006064,-0.46621885306434724,-0.3891484207838882,0.3739010427175194,-1.17331342279577,-0.46621885306434724,1.0041412915640857,1.4948164960337653,2.679467443709186,0.49703301170235065,1.865329260145266,0.6741423628769925,0.6741423628769925,0.3739010427175194,-0.5842434527420278,0.7875391296424109,0.8974686565746289,0.11412915938872559,0.21377219628069816,2.0864437380032115,4.954689535317153,-0.7873933421725157
2,631
Lipoprotein metabolic process
6
15
2.540313
0.011075
O60762,Q8N2K0,Q5MNZ6,Q9BQE5,Q9H490,Q9NUJ1
Processes and pathways
GO Biological process
msigdb_gobp
190,300,109,44,184,32
190,1241,1396,1848,2227,314,109,300,1219,1559,44,614,184,32,616
1.13319242501366,0.08028608865991266,-0.023187036139176026,-0.3891484207838882,-0.8289885581393346,0.8974686565746289,1.4486352146024881,0.9244343611620436,0.11412915938872559,-0.12957783544472734,2.3498130031826134,0.5866809767008758,1.15845820052481,2.7125106347921997,0.5866809767008758
2,631
reductase
6
28
2.531968
0.011342
Q9BY49,Q06136,Q15392,P00374,Q9UBM7,P31350
Functions
Panther Protein class
panther_protein_class
129,2,36,9,23,152
1530,367,9,1492,930,369,747,1249,2198,2559,832,1251,152,1769,2339,2,1365,36,575,1791,2188,2118,129,551,920,171,23,2475
-0.12957783544472734,0.8153380062854007,4.004804150480747,-0.09379028637419248,0.3107081753546436,0.8153380062854007,0.4359965476908903,0.08028608865991266,-0.7873933421725157,-1.9730552658909035,0.3739010427175194,0.08028608865991266,1.257791335055367,-0.31336929154874354,-1.041784332284214,5.1051968387484905,0.011628382363652217,2.5096531511230316,0.6160723009781515,-0.31336929154874354,-0.7461197124067016,-0.6645376888850335,1.330541201726474,0.6452247828693638,0.3424442560190503,1.2084658865131082,3.102383344071522,-1.3989382867201257
2,631
Lipid localization
17
55
2.52251
0.011652
Q99720,O43772,P50416,P07602,P17900,Q86Y82,Q8WTV0,Q9BQE5,Q14534,Q96SU4,Q9Y6B6,O95674,P28288,Q6IAA8,Q9C0B1,P08183,P14174
Processes and pathways
GO Biological process
msigdb_gobp
0,3,444,310,563,299,10,44,381,483,82,333,524,477,581,622,625
2130,704,2165,3,1571,1713,1240,2101,1715,333,1760,1848,1291,1531,310,2032,2268,622,1108,625,563,1158,627,524,715,835,1298,1583,892,444,1631,2357,1307,1072,381,477,1423,299,948,10,483,0,44,1280,1703,1705,581,1181,1478,2434,1749,2324,1566,1663,82
-0.705167787937405,0.46664484400905687,-0.7461197124067016,4.963710030498427,-0.16568914771639728,-0.2759642918046235,0.08028608865991266,-0.6645376888850335,-0.2759642918046235,0.8702994873684097,-0.31336929154874354,-0.3891484207838882,0.04611947228614343,-0.12957783544472734,0.8974686565746289,-0.5842434527420278,-0.9131432773169984,0.5570467687489573,0.1808662269600239,0.5570467687489573,0.6160723009781515,0.14765384784078572,0.5570467687489573,0.6452247828693638,0.46664484400905687,0.3739010427175194,0.04611947228614343,-0.16568914771639728,0.3424442560190503,0.7312880952006297,-0.2021240853281833,-1.085306619758222,0.04611947228614343,0.21377219628069816,0.8153380062854007,0.7028288840536002,-0.023187036139176026,0.9244343611620436,0.3107081753546436,3.9225804558905155,0.7028288840536002,5.562677407182912,2.3498130031826134,0.08028608865991266,-0.23888251175943867,-0.23888251175943867,0.6160723009781515,0.14765384784078572,-0.058326639732175146,-1.26260245787533,-0.2759642918046235,-0.9985829370388538,-0.12957783544472734,-0.2021240853281833,1.6299370577151888
2,631
Golgi stack
7
23
2.519541
0.011751
Q9H4A6,O00461,Q15363,Q9Y3A3,Q9Y6B6,Q8NBN3,Q14789
Localization
GO Cellular component
msigdb_gocc
67,187,5,243,82,253,86
187,1803,1150,1396,793,2068,1675,2466,532,1120,603,687,86,5,1459,253,343,729,67,1522,821,243,82
1.13319242501366,-0.3510973783434665,0.14765384784078572,-0.023187036139176026,0.40508352216113896,-0.624229536412293,-0.23888251175943867,-1.3989382867201257,0.6452247828693638,0.1808662269600239,0.5866809767008758,0.49703301170235065,1.5854529614565336,4.86328444949437,-0.058326639732175146,1.0041412915640857,0.8702994873684097,0.46664484400905687,1.865329260145266,-0.09379028637419248,0.40508352216113896,1.0303233973076291,1.6299370577151888
2,631
Protein transporter activity
7
14
2.519338
0.011758
O14925,Q15388,P49755,Q9NS69,O60830,Q99595,Q9HD20
Functions
GO Molecular function
msigdb_gomf
438,540,143,185,231,115,125
438,231,1149,1104,143,533,1069,540,1738,115,125,185,1381,1662
0.7312880952006297,1.0303233973076291,0.14765384784078572,0.1808662269600239,1.2822041225107923,0.6452247828693638,0.21377219628069816,0.6452247828693638,-0.2759642918046235,1.4018583320651603,1.3544699048423925,1.15845820052481,0.011628382363652217,-0.2021240853281833
2,631
Phospholipid binding
15
75
2.509029
0.012106
P30086,P50897,P07737,Q9H4A6,Q9H6U6,Q8WTV0,P45880,Q5MNZ6,P35080,P20073,Q9H490,P21796,Q13576,Q8NCC3,Q9Y2I1
Functions
GO Molecular function
msigdb_gomf
1,314,191,67,138,10,267,109,291,290,184,85,283,27,228
2130,1384,1842,1047,787,490,1388,1052,1617,967,1192,1392,878,1291,1531,310,191,711,2033,624,2035,1890,290,85,1,291,399,267,2108,2043,892,314,752,896,2179,724,1262,980,283,1417,1072,1074,2540,1866,109,2152,907,2159,27,2366,10,1276,1650,817,1470,1280,1657,184,67,138,1232,1478,487,2324,1709,1948,1481,1879,228,2027,2391,2461,616,1329,1287
-0.705167787937405,-0.023187036139176026,-0.3891484207838882,0.21377219628069816,0.40508352216113896,0.6741423628769925,-0.023187036139176026,0.21377219628069816,-0.2021240853281833,0.278687675691609,0.11412915938872559,-0.023187036139176026,0.3424442560190503,0.04611947228614343,-0.12957783544472734,0.8974686565746289,1.13319242501366,0.46664484400905687,-0.5842434527420278,0.5570467687489573,-0.5842434527420278,-0.4275222886859329,0.9244343611620436,1.5854529614565336,5.15692486809843,0.9244343611620436,0.7875391296424109,0.977767688006064,-0.6645376888850335,-0.5842434527420278,0.3424442560190503,0.8974686565746289,0.4359965476908903,0.3424442560190503,-0.7461197124067016,0.46664484400905687,0.08028608865991266,0.278687675691609,0.9511996966722966,-0.023187036139176026,0.21377219628069816,0.21377219628069816,-1.7765736441710231,-0.3891484207838882,1.4486352146024881,-0.705167787937405,0.3424442560190503,-0.705167787937405,2.9358813459906243,-1.085306619758222,3.9225804558905155,0.08028608865991266,-0.2021240853281833,0.40508352216113896,-0.058326639732175146,0.08028608865991266,-0.2021240853281833,1.15845820052481,1.865329260145266,1.3064533352461962,0.11412915938872559,-0.058326639732175146,0.7028288840536002,-0.9985829370388538,-0.23888251175943867,-0.46621885306434724,-0.058326639732175146,-0.3891484207838882,1.0563168307418604,-0.544579561175527,-1.129149687086767,-1.3531728506809722,0.5866809767008758,0.04611947228614343,0.08028608865991266
2,631
Vesicle coat protein
7
21
2.50622
0.012203
Q15363,Q9BVK6,P49755,Q9Y3A6,Q9Y3B3,Q9Y678,Q9UBQ0
Drugs and Diseases
Pharos Drug Target Ontology
pharos_dto
5,102,143,416,53,230,462
1244,2101,1444,1254,1500,143,1205,2141,1408,1678,797,1930,980,5,1426,102,555,462,416,53,230
0.08028608865991266,-0.6645376888850335,-0.058326639732175146,0.08028608865991266,-0.09379028637419248,1.2822041225107923,0.11412915938872559,-0.705167787937405,-0.023187036139176026,-0.23888251175943867,0.40508352216113896,-0.46621885306434724,0.278687675691609,4.86328444949437,-0.023187036139176026,1.4948164960337653,0.6452247828693638,0.7312880952006297,0.7875391296424109,2.1058970915870394,1.0563168307418604
2,631
Iron uptake and transport
9
18
2.505696
0.012221
P21281,P09601,P61421,Q93050,P02786,Q15904,P36543,Q9Y487,P30519
Processes and pathways
Reactome Pathways
msigdb_reactome
222,311,167,146,264,145,337,260,127
1530,264,311,222,335,1446,127,337,597,167,658,2361,145,1462,146,2127,260,1141
-0.12957783544472734,0.977767688006064,0.8974686565746289,1.0563168307418604,0.8702994873684097,-0.058326639732175146,1.330541201726474,0.8702994873684097,0.5866809767008758,1.2084658865131082,0.5271655315673739,-1.085306619758222,1.2822041225107923,-0.058326639732175146,1.2822041225107923,-0.6645376888850335,1.0041412915640857,0.1808662269600239
2,631
Metalloexopeptidase activity
9
20
2.491279
0.012728
P55786,Q9UIQ6,Q969V3,Q7Z2K6,P50579,P02786,P36551,Q9NZ08,P16870
Functions
GO Molecular function
msigdb_gomf
33,4,429,504,174,264,233,55,208
1335,708,264,1889,1921,208,2396,233,174,33,504,429,860,817,550,1234,1186,1092,55,4
0.011628382363652217,0.46664484400905687,0.977767688006064,-0.4275222886859329,-0.46621885306434724,1.0821243548255537,-1.17331342279577,1.0303233973076291,1.183548528852841,2.679467443709186,0.6741423628769925,0.759523653936807,0.3739010427175194,0.40508352216113896,0.6452247828693638,0.11412915938872559,0.14765384784078572,0.21377219628069816,2.0864437380032115,4.954689535317153
2,631
oxidoreductase
16
38
2.490587
0.012753
O96000,P35754,O43396,Q16718,Q8N4Q0,O75306,Q6UWP2,P23368,Q6DKJ4,O95831,O95168,O43676,O43169,Q92506,O43674,Q15067
Functions
Panther Protein class
panther_protein_class
275,497,558,450,37,219,238,348,341,46,289,262,329,426,119,248
966,1386,329,558,119,262,219,289,2031,46,275,595,1398,1996,1154,830,1345,348,1581,497,1853,1203,248,944,450,1689,1367,341,238,1937,2456,37,426,692,1427,991,2406,1664
0.278687675691609,-0.023187036139176026,0.8702994873684097,0.6160723009781515,1.3782415831495038,0.977767688006064,1.0563168307418604,0.9244343611620436,-0.5842434527420278,2.239250199852926,0.9511996966722966,0.5866809767008758,-0.023187036139176026,-0.544579561175527,0.14765384784078572,0.3739010427175194,0.011628382363652217,0.8429236851350608,-0.16568914771639728,0.6741423628769925,-0.3891484207838882,0.11412915938872559,1.0041412915640857,0.3107081753546436,0.7312880952006297,-0.23888251175943867,0.011628382363652217,0.8702994873684097,1.0303233973076291,-0.46621885306434724,-1.3531728506809722,2.5096531511230316,0.759523653936807,0.49703301170235065,-0.023187036139176026,0.278687675691609,-1.17331342279577,-0.2021240853281833
2,631
Talipes equinovarus
27
58
2.487088
0.012879
Q9UJX6,Q15427,Q8TD19,Q9UM00,O96028,Q53EZ4,Q9H3P2,O60231,P06753,Q96AY3,Q15392,P49902,P52788,Q13363,Q9HD42,Q9Y619,Q8NCH0,P36543,O75845,Q9H2M9,P61978,Q03001,P38919,P38606,Q9NWM8,Q9Y487,Q9NR77
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
273,663,544,675,140,406,287,516,521,31,36,528,529,295,699,47,319,337,332,614,471,474,598,597,118,260,258
1385,516,2348,332,1244,2132,140,1761,521,2034,830,1718,2454,684,1721,836,337,597,598,528,1676,529,1678,1118,471,1965,2179,2047,474,847,295,1418,36,663,406,1547,2519,1738,319,2117,1464,544,1084,1466,1086,31,614,287,699,258,118,273,675,1382,260,1000,1001,47
-0.023187036139176026,0.6452247828693638,-1.085306619758222,0.8702994873684097,0.08028608865991266,-0.705167787937405,1.2822041225107923,-0.31336929154874354,0.6452247828693638,-0.5842434527420278,0.3739010427175194,-0.2759642918046235,-1.3531728506809722,0.49703301170235065,-0.2759642918046235,0.3739010427175194,0.8702994873684097,0.5866809767008758,0.5866809767008758,0.6452247828693638,-0.23888251175943867,0.6452247828693638,-0.23888251175943867,0.1808662269600239,0.7028288840536002,-0.5052379861113006,-0.7461197124067016,-0.5842434527420278,0.7028288840536002,0.3739010427175194,0.9244343611620436,-0.023187036139176026,2.5096531511230316,0.5271655315673739,0.7875391296424109,-0.12957783544472734,-1.5851991561112928,-0.2759642918046235,0.8974686565746289,-0.6645376888850335,-0.058326639732175146,0.6452247828693638,0.21377219628069816,-0.058326639732175146,0.21377219628069816,2.7125106347921997,0.5866809767008758,0.9511996966722966,0.49703301170235065,1.0041412915640857,1.4018583320651603,0.977767688006064,0.5271655315673739,0.011628382363652217,1.0041412915640857,0.278687675691609,0.278687675691609,2.2204944858377984
2,631
Negative regulation of calcium ion transport
7
9
2.479686
0.01315
P30626,P78417,Q9UMX0,P28161,P21796,P0DP25,P62942
Processes and pathways
GO Biological process
msigdb_gobp
163,236,415,336,85,151,60
151,85,336,163,720,60,236,448,415
1.257791335055367,1.5854529614565336,0.8702994873684097,1.2084658865131082,0.46664484400905687,2.0274549169815406,1.0303233973076291,0.7312880952006297,0.7875391296424109
2,631
Negative regulation of calcium ion transmembrane transport
7
9
2.479686
0.01315
P30626,P78417,Q9UMX0,P28161,P21796,P0DP25,P62942
Processes and pathways
GO Biological process
msigdb_gobp
163,236,415,336,85,151,60
151,85,336,163,720,60,236,448,415
1.257791335055367,1.5854529614565336,0.8702994873684097,1.2084658865131082,0.46664484400905687,2.0274549169815406,1.0303233973076291,0.7312880952006297,0.7875391296424109
2,631
Proton transporting v type atpase complex
7
11
2.470994
0.013474
P21281,P61421,Q93050,Q15904,P36543,Q9Y487,Q8N511
Localization
GO Cellular component
msigdb_gocc
222,167,146,145,337,260,121
222,335,337,597,167,145,121,146,2127,260,1141
1.0563168307418604,0.8702994873684097,0.8702994873684097,0.5866809767008758,1.2084658865131082,1.2822041225107923,1.3782415831495038,1.2822041225107923,-0.6645376888850335,1.0041412915640857,0.1808662269600239
2,631
Oxidoreductase
46
138
2.465354
0.013688
O95881,Q9BY49,Q06136,Q15067,P09417,P30041,P00374,P49419,Q96K12,Q9H9P8,Q8NB78,P48735,Q9UBM7,Q8NBX0,P31350,O60341,Q9UHG3,Q9P2T1,P30048,Q15392,Q8N4Q0,Q13363,P53004,O75874,Q32P28,Q16836,O95831,Q16881,Q8NBQ5,O00625,Q92506,P30837,Q8TC12,P09601,Q16850,Q6DKJ4,O75845,O75251,O75306,Q6UWP2,P23368,Q14534,P78417,P36551,Q9BU89,P30519
Functions
Protein Atlas Molecular function
protein_atlas_molecular_function
367,129,2,248,369,370,9,134,270,552,13,17,23,154,152,517,30,171,525,36,37,295,530,41,296,574,46,575,577,418,426,56,451,311,202,341,332,466,219,238,348,381,236,233,124,127
1385,418,642,2063,705,1102,517,1618,466,219,1194,332,41,46,367,1441,1667,9,1492,930,1398,2102,621,1292,1762,369,311,1996,1956,1339,1623,596,1010,1668,1110,1341,747,2198,2559,830,1578,1671,1345,348,1999,832,714,370,1251,1581,525,127,56,1817,152,2137,890,1769,2339,233,1674,1854,1724,1349,2005,1203,17,2006,893,134,1351,1535,935,655,1676,1353,530,1118,757,236,1633,939,2047,2,1683,1862,1969,295,381,1365,248,36,804,944,574,202,575,296,1367,1935,341,2154,238,1936,2484,2155,1791,810,2456,37,2188,13,986,577,154,451,1978,1908,426,2280,2118,692,270,1830,1427,1132,124,129,581,956,552,640,1432,171,23,958,30,999
-0.023187036139176026,0.759523653936807,0.5271655315673739,-0.624229536412293,0.46664484400905687,0.1808662269600239,0.6452247828693638,-0.2021240853281833,0.7028288840536002,1.0563168307418604,0.11412915938872559,0.8702994873684097,2.4038695750039927,2.239250199852926,0.8153380062854007,-0.058326639732175146,-0.23888251175943867,4.004804150480747,-0.09379028637419248,0.3107081753546436,-0.023187036139176026,-0.6645376888850335,0.5570467687489573,0.04611947228614343,-0.31336929154874354,0.8153380062854007,0.8974686565746289,-0.544579561175527,-0.5052379861113006,0.011628382363652217,-0.2021240853281833,0.5866809767008758,0.24637748849157123,-0.23888251175943867,0.1808662269600239,0.011628382363652217,0.4359965476908903,-0.7873933421725157,-1.9730552658909035,0.3739010427175194,-0.16568914771639728,-0.23888251175943867,0.011628382363652217,0.8429236851350608,-0.544579561175527,0.3739010427175194,0.46664484400905687,0.8153380062854007,0.08028608865991266,-0.16568914771639728,0.6452247828693638,1.330541201726474,2.06688635784378,-0.3510973783434665,1.257791335055367,-0.705167787937405,0.3424442560190503,-0.31336929154874354,-1.041784332284214,1.0303233973076291,-0.23888251175943867,-0.3891484207838882,-0.2759642918046235,0.011628382363652217,-0.544579561175527,0.11412915938872559,3.521809624851483,-0.544579561175527,0.3424442560190503,1.3064533352461962,0.011628382363652217,-0.12957783544472734,0.3107081753546436,0.5271655315673739,-0.23888251175943867,0.011628382363652217,0.6452247828693638,0.1808662269600239,0.4359965476908903,1.0303233973076291,-0.2021240853281833,0.3107081753546436,-0.5842434527420278,5.1051968387484905,-0.23888251175943867,-0.3891484207838882,-0.5052379861113006,0.9244343611620436,0.8153380062854007,0.011628382363652217,1.0041412915640857,2.5096531511230316,0.40508352216113896,0.3107081753546436,0.6160723009781515,1.107748671810519,0.6160723009781515,0.9244343611620436,0.011628382363652217,-0.46621885306434724,0.8702994873684097,-0.705167787937405,1.0303233973076291,-0.46621885306434724,-1.445023740434061,-0.705167787937405,-0.31336929154874354,0.40508352216113896,-1.3531728506809722,2.5096531511230316,-0.7461197124067016,3.5873366483495683,0.278687675691609,0.6160723009781515,1.257791335055367,0.7312880952006297,-0.5052379861113006,-0.4275222886859329,0.759523653936807,-0.9131432773169984,-0.6645376888850335,0.49703301170235065,0.977767688006064,-0.3510973783434665,-0.023187036139176026,0.1808662269600239,1.3544699048423925,1.330541201726474,0.6160723009781515,0.3107081753546436,0.6452247828693638,0.5570467687489573,-0.023187036139176026,1.2084658865131082,3.102383344071522,0.3107081753546436,2.745260322918709,0.278687675691609
2,631
Nuclear import signal receptor activity
6
9
2.462599
0.013793
O60684,Q92973,P52292,Q96P70,Q9UI26,P52294
Functions
GO Molecular function
msigdb_gomf
94,100,420,175,52,159
824,94,420,159,1266,481,100,175,52
0.3739010427175194,1.5176885982704214,0.759523653936807,1.2332126975583004,0.08028608865991266,0.7028288840536002,1.4948164960337653,1.183548528852841,2.163644168156307
2,631
Cytoprotection by hmox1
16
60
2.462336
0.013804
P28072,O00233,P09601,O00487,Q9UL46,P25789,P28074,P25788,Q13309,P49721,Q86X55,P49720,Q99436,P20618,P28070,P30519
Processes and pathways
Reactome Pathways
msigdb_reactome
34,132,311,188,206,350,106,349,294,18,387,142,394,59,62,127
515,874,132,966,188,1843,825,2523,929,595,311,2439,2395,1668,931,1445,59,442,1011,749,349,350,973,62,34,106,1251,127,1893,1625,1626,1115,1066,142,18,1894,530,2073,378,937,1858,1257,1593,658,1208,1068,1416,294,2361,2112,1507,943,387,1170,394,2091,870,206,922,738
0.6452247828693638,0.3424442560190503,1.3064533352461962,0.278687675691609,1.13319242501366,-0.3891484207838882,0.3739010427175194,-1.6325636329473232,0.3107081753546436,0.5866809767008758,0.8974686565746289,-1.307727538673511,-1.17331342279577,-0.23888251175943867,0.3107081753546436,-0.058326639732175146,2.0274549169815406,0.7312880952006297,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,0.08028608865991266,1.330541201726474,-0.4275222886859329,-0.2021240853281833,-0.2021240853281833,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,0.6452247828693638,-0.624229536412293,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.5271655315673739,0.11412915938872559,0.21377219628069816,-0.023187036139176026,0.9244343611620436,-1.085306619758222,-0.6645376888850335,-0.09379028637419248,0.3107081753546436,0.8153380062854007,0.14765384784078572,0.8153380062854007,-0.624229536412293,0.3739010427175194,1.107748671810519,0.3424442560190503,0.46664484400905687
2,631
Antigen processing ubiquitination proteasome degradation
20
79
2.46047
0.013876
Q9UIQ6,O00233,Q9UJX6,Q92990,P49721,P49720,P55786,P28072,Q13309,P20618,P28070,O00487,Q9UL46,P52888,P25789,P28074,P49427,P25788,Q99436,Q9UJX3
Processes and pathways
Reactome Pathways
msigdb_reactome
4,132,273,137,18,142,33,34,294,59,62,188,206,97,350,106,107,349,394,126
1046,515,874,132,188,1843,825,929,1243,1445,59,2170,1011,749,349,350,973,62,34,106,1346,1200,1893,1115,1066,107,142,18,1894,97,2073,33,378,531,1357,1304,937,1858,1257,1593,658,900,537,1068,2506,1416,294,2361,604,2112,1504,2012,1507,943,2611,1639,850,1640,1544,2314,2610,2316,1739,137,1649,394,2091,1472,731,4,2555,126,674,273,206,1836,820,922,964
0.21377219628069816,0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,0.3107081753546436,0.08028608865991266,-0.058326639732175146,2.0274549169815406,-0.7461197124067016,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,0.011628382363652217,0.11412915938872559,-0.4275222886859329,0.1808662269600239,0.21377219628069816,1.47179933358734,1.2822041225107923,3.3458384043052356,-0.4275222886859329,1.4948164960337653,-0.624229536412293,2.679467443709186,0.8153380062854007,0.6452247828693638,0.011628382363652217,0.04611947228614343,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.5271655315673739,0.3424442560190503,0.6452247828693638,0.21377219628069816,-1.538154279489105,-0.023187036139176026,0.9244343611620436,-1.085306619758222,0.5866809767008758,-0.6645376888850335,-0.09379028637419248,-0.544579561175527,-0.09379028637419248,0.3107081753546436,-3.0881299863313427,-0.2021240853281833,0.3739010427175194,-0.2021240853281833,-0.12957783544472734,-0.9985829370388538,-2.864935395710789,-0.9985829370388538,-0.2759642918046235,1.3064533352461962,-0.2021240853281833,0.8153380062854007,-0.624229536412293,-0.058326639732175146,0.46664484400905687,4.954689535317153,-1.9234564142985089,1.3544699048423925,0.5271655315673739,0.977767688006064,1.107748671810519,-0.3510973783434665,0.40508352216113896,0.3424442560190503,0.3107081753546436
2,631
Abnormal circulating lipid concentration
20
63
2.447483
0.014386
P23786,Q92734,O43772,P40855,Q15904,Q9UBM7,O75431,Q15392,Q16836,P28070,Q15056,P07602,P50416,P50402,Q9Y6B6,O75845,O75648,P35914,P49257,Q8N511
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
627,546,3,373,145,23,645,36,574,62,725,310,444,565,82,332,592,223,234,121
1190,2393,1147,3,1952,645,592,1335,332,791,1847,880,1246,310,1996,1339,1812,627,62,1014,835,1348,223,1771,373,1724,838,1501,234,1351,565,444,934,1676,2072,1679,978,1631,1964,1120,1966,1683,1262,1365,725,36,804,145,574,121,546,1219,1607,956,994,1478,870,23,2448,1565,736,1327,82
0.11412915938872559,-1.17331342279577,0.14765384784078572,4.963710030498427,-0.5052379861113006,0.5271655315673739,0.5866809767008758,0.011628382363652217,0.8702994873684097,0.40508352216113896,-0.3891484207838882,0.3424442560190503,0.08028608865991266,0.8974686565746289,-0.544579561175527,0.011628382363652217,-0.3510973783434665,0.5570467687489573,2.007578507508111,0.24637748849157123,0.3739010427175194,0.011628382363652217,1.0563168307418604,-0.31336929154874354,0.8153380062854007,-0.2759642918046235,0.3739010427175194,-0.09379028637419248,1.0303233973076291,0.011628382363652217,0.6160723009781515,0.7312880952006297,0.3107081753546436,-0.23888251175943867,-0.624229536412293,-0.23888251175943867,0.278687675691609,-0.2021240853281833,-0.5052379861113006,0.1808662269600239,-0.5052379861113006,-0.23888251175943867,0.08028608865991266,0.011628382363652217,0.46664484400905687,2.5096531511230316,0.40508352216113896,1.2822041225107923,0.6160723009781515,1.3782415831495038,0.6452247828693638,0.11412915938872559,-0.16568914771639728,0.3107081753546436,0.278687675691609,-0.058326639732175146,0.3739010427175194,3.102383344071522,-1.307727538673511,-0.12957783544472734,0.46664484400905687,0.04611947228614343,1.6299370577151888
2,631
Transferrin endocytosis and recycling
7
11
2.442714
0.014577
P21281,P61421,Q93050,P02786,Q15904,P36543,Q9Y487
Processes and pathways
Reactome Pathways
msigdb_reactome
222,167,146,264,145,337,260
264,222,335,337,597,167,145,146,2127,260,1141
0.977767688006064,1.0563168307418604,0.8702994873684097,0.8702994873684097,0.5866809767008758,1.2084658865131082,1.2822041225107923,1.2822041225107923,-0.6645376888850335,1.0041412915640857,0.1808662269600239
2,631
Signaling by hedgehog
14
55
2.441899
0.01461
P28072,O00233,O00487,Q9UL46,P49841,P25789,Q9UBV2,P28074,P25788,P49721,P49720,Q99436,P20618,P28070
Processes and pathways
Reactome Pathways
msigdb_reactome
34,132,188,206,351,350,73,106,349,18,142,394,59,62
515,874,132,188,1843,825,929,1995,1338,1295,1197,1445,59,1011,749,349,350,973,62,34,106,1893,1115,1066,527,142,18,351,1894,2073,1895,378,937,1858,1257,1593,658,2494,1068,1416,849,2361,2112,662,1507,943,2278,394,2091,457,989,73,206,922,2129
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,0.3107081753546436,-0.544579561175527,0.011628382363652217,0.04611947228614343,0.11412915938872559,-0.058326639732175146,2.0274549169815406,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.4275222886859329,0.1808662269600239,0.21377219628069816,0.6452247828693638,1.2822041225107923,3.3458384043052356,0.8429236851350608,-0.4275222886859329,-0.624229536412293,-0.4275222886859329,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.5271655315673739,-1.4914291062743523,0.21377219628069816,-0.023187036139176026,0.3739010427175194,-1.085306619758222,-0.6645376888850335,0.5271655315673739,-0.09379028637419248,0.3107081753546436,-0.9131432773169984,0.8153380062854007,-0.624229536412293,0.7312880952006297,0.278687675691609,1.781481931571495,1.107748671810519,0.3424442560190503,-0.6645376888850335
2,631
Protein transmembrane transport
11
22
2.436961
0.014811
O14925,Q15388,Q3ZCQ8,Q15629,O95831,P49755,Q9NS69,O60830,Q99595,O75298,P60468
Processes and pathways
GO Biological process
msigdb_gobp
438,540,541,144,46,143,185,231,115,207,193
438,1802,231,207,1952,1149,46,1104,2334,835,143,193,1775,533,1069,540,144,541,115,669,185,1381
0.7312880952006297,-0.3510973783434665,1.0303233973076291,1.0821243548255537,-0.5052379861113006,0.14765384784078572,2.239250199852926,0.1808662269600239,-1.041784332284214,0.3739010427175194,1.2822041225107923,1.13319242501366,-0.31336929154874354,0.6452247828693638,0.21377219628069816,0.6452247828693638,1.2822041225107923,0.6452247828693638,1.4018583320651603,0.5271655315673739,1.15845820052481,0.011628382363652217
2,631
Abnormal circulating cholesterol concentration
6
26
2.429527
0.015119
Q15392,P07602,Q15904,Q9Y6B6,Q9UBM7,Q8N511
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
36,310,145,82,23,121
2393,645,332,1847,1246,310,1771,838,1501,565,934,978,1631,1120,1262,1365,36,804,145,121,1607,994,1478,23,1565,82
-1.17331342279577,0.5271655315673739,0.8702994873684097,-0.3891484207838882,0.08028608865991266,0.8974686565746289,-0.31336929154874354,0.3739010427175194,-0.09379028637419248,0.6160723009781515,0.3107081753546436,0.278687675691609,-0.2021240853281833,0.1808662269600239,0.08028608865991266,0.011628382363652217,2.5096531511230316,0.40508352216113896,1.2822041225107923,1.3782415831495038,-0.16568914771639728,0.278687675691609,-0.058326639732175146,3.102383344071522,-0.12957783544472734,1.6299370577151888
2,631
Metabolism of vitamins and cofactors
15
35
2.427109
0.01522
Q9BQG2,Q8TC12,Q9H2D1,Q9NRN7,Q99707,P05165,P43490,O75874,P00374,P78417,P41440,Q9NVE7,Q9NZJ6,Q9Y289,P34897
Processes and pathways
Reactome Pathways
msigdb_reactome
64,451,130,131,169,561,374,41,9,236,49,186,554,586,371
704,589,41,9,1492,561,2067,1108,713,1849,1341,1297,371,2339,49,374,893,2008,236,2149,1548,2456,948,1127,451,1980,1035,169,64,130,2059,131,186,554,586
0.46664484400905687,0.5866809767008758,2.4038695750039927,4.004804150480747,-0.09379028637419248,0.6160723009781515,-0.624229536412293,0.1808662269600239,0.46664484400905687,-0.3891484207838882,0.011628382363652217,0.04611947228614343,0.8153380062854007,-1.041784332284214,2.2016422601947694,0.8153380062854007,0.3424442560190503,-0.544579561175527,1.0303233973076291,-0.705167787937405,-0.12957783544472734,-1.3531728506809722,0.3107081753546436,0.1808662269600239,0.7312880952006297,-0.5052379861113006,0.24637748849157123,1.2084658865131082,1.9674982888411903,1.330541201726474,-0.5842434527420278,1.330541201726474,1.15845820052481,0.6452247828693638,0.6160723009781515
2,631
Negative regulation of cation channel activity
6
7
2.418189
0.015598
P30626,P78417,Q9UMX0,P28161,P0DP25,P62942
Processes and pathways
GO Biological process
msigdb_gobp
163,236,415,336,151,60
151,336,163,60,236,448,415
1.257791335055367,0.8702994873684097,1.2084658865131082,2.0274549169815406,1.0303233973076291,0.7312880952006297,0.7875391296424109
2,631
Negative regulation of ion transmembrane transporter activity
7
10
2.416778
0.015659
P30626,P78417,Q9UMX0,P28161,Q9HD26,P0DP25,P62942
Processes and pathways
GO Biological process
msigdb_gobp
163,236,415,336,459,151,60
1710,151,336,163,720,60,236,448,459,415
-0.2759642918046235,1.257791335055367,0.8702994873684097,1.2084658865131082,0.46664484400905687,2.0274549169815406,1.0303233973076291,0.7312880952006297,0.7312880952006297,0.7875391296424109
2,631
Retrograde vesicle mediated transport golgi to endoplasmic reticulum
9
27
2.415488
0.015714
Q9H4A6,Q8WVM8,P49755,P83436,O43731,P18085,Q9Y282,P24390,Q96RQ1
Processes and pathways
GO Biological process
msigdb_gobp
67,343,143,282,54,179,29,123,393
1916,2522,54,1758,179,123,1254,838,1500,892,143,2141,797,282,422,801,1547,1464,343,1276,1466,393,67,1322,1188,555,29
-0.46621885306434724,-1.6325636329473232,2.0864437380032115,-0.31336929154874354,1.15845820052481,1.3544699048423925,0.08028608865991266,0.3739010427175194,-0.09379028637419248,0.3424442560190503,1.2822041225107923,-0.705167787937405,0.40508352216113896,0.9511996966722966,0.759523653936807,0.40508352216113896,-0.12957783544472734,-0.058326639732175146,0.8702994873684097,0.08028608865991266,-0.058326639732175146,0.8153380062854007,1.865329260145266,0.04611947228614343,0.14765384784078572,0.6452247828693638,2.841800548164946
2,631
Signaling by insulin receptor
8
15
2.411736
0.015877
P21281,P61421,Q93050,Q15904,P36543,Q9Y487,P62993,P21283
Processes and pathways
Reactome Pathways
msigdb_reactome
222,167,146,145,337,260,210,335
222,335,419,1721,835,337,597,167,210,1307,145,146,2127,260,1141
1.0563168307418604,0.8702994873684097,0.759523653936807,-0.2759642918046235,0.3739010427175194,0.8702994873684097,0.5866809767008758,1.2084658865131082,1.0821243548255537,0.04611947228614343,1.2822041225107923,1.2822041225107923,-0.6645376888850335,1.0041412915640857,0.1808662269600239
2,631
Peptidyl proline modification
10
28
2.410378
0.015936
Q96AY3,P45877,Q9BV86,Q32P28,P26885,Q9Y3C6,Q9NWM8,Q14318,P62942,O75718
Processes and pathways
GO Biological process
msigdb_gobp
31,313,11,296,16,229,118,380,60,158
417,705,875,158,1995,1110,1533,16,2039,313,2399,60,659,760,2204,1969,940,2184,380,688,296,1604,31,692,11,118,2062,229
0.759523653936807,0.46664484400905687,0.3424442560190503,1.2332126975583004,-0.544579561175527,0.1808662269600239,-0.12957783544472734,3.548158845230379,-0.5842434527420278,0.8974686565746289,-1.17331342279577,2.0274549169815406,0.5271655315673739,0.4359965476908903,-0.7873933421725157,-0.5052379861113006,0.3107081753546436,-0.7461197124067016,0.8153380062854007,0.49703301170235065,0.9244343611620436,-0.16568914771639728,2.7125106347921997,0.49703301170235065,3.8867815235067193,1.4018583320651603,-0.5842434527420278,1.0563168307418604
2,631
Thiolester hydrolase activity
6
15
2.407762
0.016051
P50897,Q8N2K0,Q9UMR5,P28288,O14734,Q9NUJ1
Functions
GO Molecular function
msigdb_gomf
314,300,156,524,489,32
1666,489,1241,1396,1532,524,1773,893,314,1369,300,584,32,156,1484
-0.23888251175943867,0.6741423628769925,0.08028608865991266,-0.023187036139176026,-0.12957783544472734,0.6452247828693638,-0.31336929154874354,0.3424442560190503,0.8974686565746289,0.011628382363652217,0.9244343611620436,0.6160723009781515,2.7125106347921997,1.257791335055367,-0.058326639732175146
2,631
Mapk family signaling cascades
23
82
2.406501
0.016106
P30086,O00233,P49721,P49720,P30153,O43924,P28072,O60725,P36404,Q96P70,P27361,P20618,P28070,O00487,Q9UL46,P62993,Q9Y2Q5,P25789,P28074,P25788,Q99436,P62140,P60900
Processes and pathways
Reactome Pathways
msigdb_reactome
1,132,18,142,280,396,34,172,173,175,419,59,62,188,206,210,96,350,106,349,394,379,378
515,874,132,188,1843,925,825,396,172,1241,929,1761,1107,1197,1445,2378,59,652,2464,1011,749,349,350,419,973,62,34,106,1721,1,280,1253,1447,1893,173,1061,1115,2043,1066,142,18,1894,656,2073,378,445,937,379,1858,1257,1593,210,2109,2179,1261,2358,1307,1068,2050,1635,1416,1360,2112,2362,1506,1507,943,2235,806,175,861,394,2091,1036,698,2488,2283,206,922,96,2391,2461
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3107081753546436,0.3739010427175194,0.7875391296424109,1.183548528852841,0.08028608865991266,0.3107081753546436,-0.31336929154874354,0.1808662269600239,0.11412915938872559,-0.058326639732175146,-1.129149687086767,2.0274549169815406,0.5271655315673739,-1.3989382867201257,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.759523653936807,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.2759642918046235,5.15692486809843,0.9511996966722966,0.08028608865991266,-0.058326639732175146,-0.4275222886859329,1.183548528852841,0.21377219628069816,0.1808662269600239,-0.5842434527420278,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,0.5271655315673739,-0.624229536412293,0.8153380062854007,0.7312880952006297,0.3107081753546436,0.8153380062854007,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,1.0821243548255537,-0.6645376888850335,-0.7461197124067016,0.08028608865991266,-1.085306619758222,0.04611947228614343,0.21377219628069816,-0.5842434527420278,-0.2021240853281833,-0.023187036139176026,0.011628382363652217,-0.6645376888850335,-1.085306619758222,-0.09379028637419248,-0.09379028637419248,0.3107081753546436,-0.8289885581393346,0.40508352216113896,1.183548528852841,0.3739010427175194,0.8153380062854007,-0.624229536412293,0.24637748849157123,0.49703301170235065,-1.445023740434061,-0.9131432773169984,1.107748671810519,0.3424442560190503,1.5176885982704214,-1.129149687086767,-1.3531728506809722
2,631
Copii mediated vesicle transport
11
27
2.40309
0.016257
Q92734,Q15363,Q8WVM8,P54920,P49755,Q12907,Q9Y6B6,P49257,O15498,P62820,Q15436
Processes and pathways
Reactome Pathways
msigdb_reactome
546,5,343,292,143,422,82,234,328,500,61
2438,788,328,1803,1758,1244,2101,1675,234,143,1354,1678,292,500,422,1784,5,61,576,1509,343,546,693,1795,821,82,1045
-1.307727538673511,0.40508352216113896,0.8702994873684097,-0.3510973783434665,-0.31336929154874354,0.08028608865991266,-0.6645376888850335,-0.23888251175943867,1.0303233973076291,1.2822041225107923,0.011628382363652217,-0.23888251175943867,0.9244343611620436,0.6741423628769925,0.759523653936807,-0.31336929154874354,4.86328444949437,2.0274549169815406,0.6160723009781515,-0.09379028637419248,0.8702994873684097,0.6452247828693638,0.49703301170235065,-0.31336929154874354,0.40508352216113896,1.6299370577151888,0.24637748849157123
2,631
Regulation of cholesterol biosynthesis by srebp srebf
7
22
2.395096
0.016616
P48449,Q16850,Q14534,Q9Y6B6,O75845,Q9UBM7,Q15436
Processes and pathways
Reactome Pathways
msigdb_reactome
8,202,381,82,332,23,61
704,642,332,2101,883,1771,8,893,686,1678,1538,2046,2149,1023,381,1266,2207,61,202,387,23,82
0.46664484400905687,0.5271655315673739,0.8702994873684097,-0.6645376888850335,0.3424442560190503,-0.31336929154874354,4.016404489026196,0.3424442560190503,0.49703301170235065,-0.23888251175943867,-0.12957783544472734,-0.5842434527420278,-0.705167787937405,0.24637748849157123,0.8153380062854007,0.08028608865991266,-0.7873933421725157,2.0274549169815406,1.107748671810519,0.8153380062854007,3.102383344071522,1.6299370577151888
2,631
Protein transmembrane transporter activity
6
11
2.385819
0.017041
O14925,Q15388,P49755,Q9NS69,O60830,Q99595
Functions
GO Molecular function
msigdb_gomf
438,540,143,185,231,115
438,231,1149,1104,143,533,1069,540,115,185,1381
0.7312880952006297,1.0303233973076291,0.14765384784078572,0.1808662269600239,1.2822041225107923,0.6452247828693638,0.21377219628069816,0.6452247828693638,1.4018583320651603,1.15845820052481,0.011628382363652217
2,631
Negative regulation of hydrolase activity
6
48
2.383039
0.01717
P30086,Q15392,Q15363,Q9H6U6,P49755,P62942
Processes and pathways
GO Biological process
msigdb_gobp
1,36,5,138,143,60
417,1099,1143,1006,744,1291,2102,1888,1153,1531,830,1111,1581,525,1,1016,2270,173,143,351,2413,376,1537,897,1453,60,1021,1210,1635,980,2539,688,5,36,1211,1075,1423,611,1911,1472,138,2459,869,1878,2489,641,1615,1002
0.759523653936807,0.1808662269600239,0.14765384784078572,0.24637748849157123,0.4359965476908903,0.04611947228614343,-0.6645376888850335,-0.4275222886859329,0.14765384784078572,-0.12957783544472734,0.3739010427175194,0.1808662269600239,-0.16568914771639728,0.6452247828693638,5.15692486809843,0.24637748849157123,-0.9131432773169984,1.183548528852841,1.2822041225107923,0.8429236851350608,-1.217797716297186,0.8153380062854007,-0.12957783544472734,0.3424442560190503,-0.058326639732175146,2.0274549169815406,0.24637748849157123,0.11412915938872559,-0.2021240853281833,0.278687675691609,-1.7765736441710231,0.49703301170235065,4.86328444949437,2.5096531511230316,0.11412915938872559,0.21377219628069816,-0.023187036139176026,0.5866809767008758,-0.4275222886859329,-0.058326639732175146,1.3064533352461962,-1.3531728506809722,0.3739010427175194,-0.3891484207838882,-1.445023740434061,0.5570467687489573,-0.16568914771639728,0.278687675691609
2,631
Mitochondrial complex i assembly model oxphos system
9
21
2.380942
0.017268
O96000,Q9NPL8,Q9BQ95,O75306,Q9BUB7,O95168,O43676,Q7L592,O43674
Processes and pathways
WikiPathways
msigdb_wp
275,433,304,219,305,289,262,81,119
119,262,219,1194,289,2031,1151,275,1578,714,450,81,1602,304,1133,305,956,433,2265,1094,1664
1.3782415831495038,0.977767688006064,1.0563168307418604,0.11412915938872559,0.9244343611620436,-0.5842434527420278,0.14765384784078572,0.9511996966722966,-0.16568914771639728,0.46664484400905687,0.7312880952006297,1.6299370577151888,-0.16568914771639728,0.9244343611620436,0.1808662269600239,0.9244343611620436,0.3107081753546436,0.759523653936807,-0.8709052422195689,0.21377219628069816,-0.2021240853281833
2,631
Ciliopathies
9
13
2.367121
0.017927
P36405,Q86Y56,Q15555,Q8TD19,Q10713,Q9UBB4,Q96EX3,Q9BW83,O43924
Processes and pathways
WikiPathways
msigdb_wp
312,251,664,544,687,413,322,256,396
396,312,1120,687,664,251,544,1172,322,256,777,1234,413
0.7875391296424109,0.8974686565746289,0.1808662269600239,0.49703301170235065,0.5271655315673739,1.0041412915640857,0.6452247828693638,0.14765384784078572,0.8974686565746289,1.0041412915640857,0.4359965476908903,0.11412915938872559,0.7875391296424109
2,631
N methyltransferase activity
7
16
2.346439
0.018954
Q99873,Q9H7B4,Q7Z2T5,Q7L592,Q86X55,O96028,O60678
Functions
GO Molecular function
msigdb_gomf
303,6,609,81,387,140,330
1882,330,592,140,1811,899,981,1268,1508,81,609,1371,387,303,6,1564
-0.4275222886859329,0.8702994873684097,0.5866809767008758,1.2822041225107923,-0.3510973783434665,0.3424442560190503,0.278687675691609,0.08028608865991266,-0.09379028637419248,1.6299370577151888,0.5866809767008758,0.011628382363652217,0.8153380062854007,0.9244343611620436,4.119223867396464,-0.12957783544472734
2,631
Cellular response to chemical stress
22
70
2.343025
0.019128
P30041,O00233,P49721,P49720,O00231,P28072,P30048,P53004,Q13309,P20618,P28070,P09601,O00487,Q9UL46,P20674,P25789,P28074,P25788,Q86X55,Q99436,P60900,P30519
Processes and pathways
Reactome Pathways
msigdb_reactome
370,132,18,142,515,34,525,530,294,59,62,311,188,206,442,350,106,349,387,394,378,127
515,874,132,966,188,1843,825,2523,929,930,595,1398,1995,311,2439,2395,1668,931,1445,59,442,1011,749,349,350,973,62,34,106,370,1251,1581,525,127,890,1893,1625,1626,1115,1066,142,18,1894,530,2073,378,937,1858,1257,1593,658,1208,1068,1416,294,2361,2112,1507,943,575,387,1170,1978,692,394,2091,870,206,922,738
0.6452247828693638,0.3424442560190503,1.3064533352461962,0.278687675691609,1.13319242501366,-0.3891484207838882,0.3739010427175194,-1.6325636329473232,0.3107081753546436,0.3107081753546436,0.5866809767008758,-0.023187036139176026,-0.544579561175527,0.8974686565746289,-1.307727538673511,-1.17331342279577,-0.23888251175943867,0.3107081753546436,-0.058326639732175146,2.0274549169815406,0.7312880952006297,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,0.8153380062854007,0.08028608865991266,-0.16568914771639728,0.6452247828693638,1.330541201726474,0.3424442560190503,-0.4275222886859329,-0.2021240853281833,-0.2021240853281833,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,0.6452247828693638,-0.624229536412293,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.5271655315673739,0.11412915938872559,0.21377219628069816,-0.023187036139176026,0.9244343611620436,-1.085306619758222,-0.6645376888850335,-0.09379028637419248,0.3107081753546436,0.6160723009781515,0.8153380062854007,0.14765384784078572,-0.5052379861113006,0.49703301170235065,0.8153380062854007,-0.624229536412293,0.3739010427175194,1.107748671810519,0.3424442560190503,0.46664484400905687
2,631
Organelle envelope lumen
9
30
2.333297
0.019633
Q9HB71,Q96BR5,Q96AY3,Q9H4A6,P52888,Q9NR28,P36404,O95831,P36551
Localization
GO Cellular component
msigdb_gocc
160,301,31,67,97,103,173,46,233
1436,438,1050,1052,46,881,494,714,173,233,97,1856,1358,1540,1904,983,1644,2535,2343,31,301,1911,1516,325,916,67,160,103,2324,1662
-0.058326639732175146,0.7312880952006297,0.21377219628069816,0.21377219628069816,2.239250199852926,0.3424442560190503,0.6741423628769925,0.46664484400905687,1.183548528852841,1.0303233973076291,1.4948164960337653,-0.3891484207838882,0.011628382363652217,-0.12957783544472734,-0.4275222886859329,0.278687675691609,-0.2021240853281833,-1.728250978286897,-1.041784332284214,2.7125106347921997,0.9244343611620436,-0.4275222886859329,-0.09379028637419248,0.8974686565746289,0.3424442560190503,1.865329260145266,1.2332126975583004,1.4948164960337653,-0.9985829370388538,-0.2021240853281833
2,631
Mapk6 mapk4 signaling
12
50
2.33087
0.01976
P28072,O00233,O00487,Q9UL46,P25789,P28074,P25788,P49721,P49720,Q99436,P20618,P28070
Processes and pathways
Reactome Pathways
msigdb_reactome
34,132,188,206,350,106,349,18,142,394,59,62
515,874,132,188,1843,925,825,929,1761,1107,1197,1445,59,2464,1011,749,349,350,973,62,34,106,1893,1115,1066,142,18,1894,2073,378,445,937,1858,1257,1593,2109,1068,2050,1635,1416,1507,943,2235,806,394,2091,698,2283,206,922
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3107081753546436,0.3739010427175194,0.3107081753546436,-0.31336929154874354,0.1808662269600239,0.11412915938872559,-0.058326639732175146,2.0274549169815406,-1.3989382867201257,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.4275222886859329,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,-0.624229536412293,0.8153380062854007,0.7312880952006297,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,-0.6645376888850335,0.21377219628069816,-0.5842434527420278,-0.2021240853281833,-0.023187036139176026,-0.09379028637419248,0.3107081753546436,-0.8289885581393346,0.40508352216113896,0.8153380062854007,-0.624229536412293,0.49703301170235065,-0.9131432773169984,1.107748671810519,0.3424442560190503
2,631
Golgi cisterna
6
14
2.330295
0.019791
Q9H4A6,O00461,Q15363,Q9Y3A3,Q9Y6B6,Q8NBN3
Localization
GO Cellular component
msigdb_gocc
67,187,5,243,82,253
187,1150,793,2068,2466,603,687,5,1459,253,343,67,243,82
1.13319242501366,0.14765384784078572,0.40508352216113896,-0.624229536412293,-1.3989382867201257,0.5866809767008758,0.49703301170235065,4.86328444949437,-0.058326639732175146,1.0041412915640857,0.8702994873684097,1.865329260145266,1.0303233973076291,1.6299370577151888
2,631
Neddylation
23
70
2.315944
0.020561
O00233,Q92905,Q9UBW8,P49721,P49720,O00231,P28072,P61081,Q13309,P61962,P20618,P28070,O94888,O00487,Q9UL46,Q86X83,Q99627,Q13098,P25789,P28074,P25788,Q99436,P60900
Processes and pathways
Reactome Pathways
msigdb_reactome
132,269,414,18,142,515,34,531,294,421,59,62,560,188,206,480,484,224,350,106,349,394,378
515,874,132,188,1843,825,2221,929,560,1445,59,1011,749,349,350,973,62,34,106,1893,1115,1066,142,18,1894,2073,378,531,897,937,421,899,1858,1257,1593,658,1068,224,1416,294,1732,2361,604,2112,1264,1507,943,1268,2611,1639,850,766,689,1462,480,1739,269,1649,394,2091,484,863,1177,1178,414,206,922,1285,1915,823
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,-0.8289885581393346,0.3107081753546436,0.6160723009781515,-0.058326639732175146,2.0274549169815406,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.4275222886859329,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,-0.624229536412293,0.8153380062854007,0.6452247828693638,0.3424442560190503,0.3107081753546436,0.759523653936807,0.3424442560190503,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.5271655315673739,0.21377219628069816,1.0563168307418604,-0.023187036139176026,0.9244343611620436,-0.2759642918046235,-1.085306619758222,0.5866809767008758,-0.6645376888850335,0.08028608865991266,-0.09379028637419248,0.3107081753546436,0.08028608865991266,-3.0881299863313427,-0.2021240853281833,0.3739010427175194,0.4359965476908903,0.49703301170235065,-0.058326639732175146,0.7028288840536002,-0.2759642918046235,0.977767688006064,-0.2021240853281833,0.8153380062854007,-0.624229536412293,0.7028288840536002,0.3739010427175194,0.14765384784078572,0.14765384784078572,0.7875391296424109,1.107748671810519,0.3424442560190503,0.08028608865991266,-0.4275222886859329,0.40508352216113896
2,631
Clonus
9
25
2.312355
0.020758
Q99720,P07602,Q3ZCQ8,Q8N0X7,P35637,Q9Y619,Q6PJG6,O75298,Q9Y5P6
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
0,310,541,388,266,47,479,207,91
517,1391,207,2247,310,713,2250,266,838,1501,1256,2179,1120,847,541,479,388,1219,0,2021,1185,1478,820,91,47
0.6452247828693638,-0.023187036139176026,1.0821243548255537,-0.8709052422195689,0.8974686565746289,0.46664484400905687,-0.8709052422195689,0.977767688006064,0.3739010427175194,-0.09379028637419248,0.08028608865991266,-0.7461197124067016,0.1808662269600239,0.3739010427175194,0.6452247828693638,0.7028288840536002,0.8153380062854007,0.11412915938872559,5.562677407182912,-0.544579561175527,0.14765384784078572,-0.058326639732175146,0.40508352216113896,1.563005024641663,2.2204944858377984
2,631
Proton transporting two sector atpase complex
9
21
2.309552
0.020913
P21281,P61421,O75964,Q93050,Q15904,P36543,Q9Y487,Q8N511,P21283
Localization
GO Cellular component
msigdb_gocc
222,167,198,146,145,337,260,121,335
1195,198,647,222,335,887,2201,1060,337,597,1725,1206,1356,167,145,121,146,453,2127,260,1141
0.11412915938872559,1.107748671810519,0.5271655315673739,1.0563168307418604,0.8702994873684097,0.3424442560190503,-0.7873933421725157,0.21377219628069816,0.8702994873684097,0.5866809767008758,-0.2759642918046235,0.11412915938872559,0.011628382363652217,1.2084658865131082,1.2822041225107923,1.3782415831495038,1.2822041225107923,0.7312880952006297,-0.6645376888850335,1.0041412915640857,0.1808662269600239
2,631
Mitochondrial transport
32
75
2.308624
0.020964
P23786,O43772,O14737,Q15388,Q3ZCQ8,Q9HAV7,P45880,Q99797,O75431,P06576,P55786,O95831,O00170,Q9NS69,Q10713,Q8N4H5,Q5JRX3,P50416,O14925,O75964,Q9Y512,Q96EK5,Q9UBX3,Q9GZY8,O75439,P30536,P49841,Q9UII2,Q16611,P49257,O60830,Q99595
Processes and pathways
GO Biological process
msigdb_gobp
627,3,133,540,541,669,267,409,645,647,33,46,417,185,687,194,66,444,438,198,346,215,84,613,706,715,351,641,112,234,231,115
1436,417,133,438,1050,1802,3,231,645,706,1195,198,1149,1621,46,1104,1106,1805,647,2067,1056,2334,1920,627,887,2201,2039,2227,715,2306,1060,1773,267,1725,891,234,351,444,2466,1590,33,1206,1356,900,687,2363,540,2150,112,541,983,66,946,2316,1372,769,194,2117,215,2056,115,409,613,669,185,1094,1660,84,641,1565,2324,1986,962,346,1662
-0.058326639732175146,0.759523653936807,1.3064533352461962,0.7312880952006297,0.21377219628069816,-0.3510973783434665,4.963710030498427,1.0303233973076291,0.5271655315673739,0.46664484400905687,0.11412915938872559,1.107748671810519,0.14765384784078572,-0.2021240853281833,2.239250199852926,0.1808662269600239,0.1808662269600239,-0.3510973783434665,0.5271655315673739,-0.624229536412293,0.21377219628069816,-1.041784332284214,-0.46621885306434724,0.5570467687489573,0.3424442560190503,-0.7873933421725157,-0.5842434527420278,-0.8289885581393346,0.46664484400905687,-0.9985829370388538,0.21377219628069816,-0.31336929154874354,0.977767688006064,-0.2759642918046235,0.3424442560190503,1.0303233973076291,0.8429236851350608,0.7312880952006297,-1.3989382867201257,-0.16568914771639728,2.679467443709186,0.11412915938872559,0.011628382363652217,0.3424442560190503,0.49703301170235065,-1.085306619758222,0.6452247828693638,-0.705167787937405,1.4253222050252763,0.6452247828693638,0.278687675691609,1.865329260145266,0.3107081753546436,-0.9985829370388538,0.011628382363652217,0.4359965476908903,1.13319242501366,-0.6645376888850335,1.0821243548255537,-0.5842434527420278,1.4018583320651603,0.7875391296424109,0.5866809767008758,0.5271655315673739,1.15845820052481,0.21377219628069816,-0.2021240853281833,1.6077630652259416,0.5570467687489573,-0.12957783544472734,-0.9985829370388538,-0.5052379861113006,0.3107081753546436,0.8702994873684097,-0.2021240853281833
2,631
Oxidoreductase
33
99
2.305798
0.021122
O95881,Q9BY49,P09417,P30041,P00374,P49419,Q9H9P8,Q9H7Z7,Q9UBM7,Q8NCN5,P31350,P30048,Q15392,Q8N4Q0,P53004,O95831,O95168,Q92506,P30837,Q8TC12,Q16718,P14406,P20674,Q16850,O43169,O75845,O75251,O75306,Q6UWP2,Q14534,P36551,O43674,Q15067
Drugs and Diseases
Pharos Drug Target Ontology
pharos_dto
367,129,369,370,9,134,552,551,23,285,152,525,36,37,530,46,289,426,56,451,450,72,442,202,329,332,466,219,238,381,233,119,248
1385,966,329,1102,119,2523,2267,466,219,332,1530,289,46,367,1441,1667,9,930,595,1398,2102,621,1292,369,1996,2395,1339,1623,596,1154,1341,72,747,1249,2198,931,442,1671,1999,832,714,2338,370,1251,525,56,1817,152,2137,890,233,1853,1674,1854,1349,2006,134,1351,1535,655,1353,530,1118,939,2047,1969,1823,381,1365,248,36,944,450,1689,202,575,1367,238,2484,2456,37,2188,1696,285,451,1978,426,692,1427,129,551,956,552,1432,1094,23,958,2475,1664
-0.023187036139176026,0.278687675691609,0.8702994873684097,0.1808662269600239,1.3782415831495038,-1.6325636329473232,-0.9131432773169984,0.7028288840536002,1.0563168307418604,0.8702994873684097,-0.12957783544472734,0.9244343611620436,2.239250199852926,0.8153380062854007,-0.058326639732175146,-0.23888251175943867,4.004804150480747,0.3107081753546436,0.5866809767008758,-0.023187036139176026,-0.6645376888850335,0.5570467687489573,0.04611947228614343,0.8153380062854007,-0.544579561175527,-1.17331342279577,0.011628382363652217,-0.2021240853281833,0.5866809767008758,0.14765384784078572,0.011628382363652217,1.781481931571495,0.4359965476908903,0.08028608865991266,-0.7873933421725157,0.3107081753546436,0.7312880952006297,-0.23888251175943867,-0.544579561175527,0.3739010427175194,0.46664484400905687,-1.041784332284214,0.8153380062854007,0.08028608865991266,0.6452247828693638,2.06688635784378,-0.3510973783434665,1.257791335055367,-0.705167787937405,0.3424442560190503,1.0303233973076291,-0.3891484207838882,-0.23888251175943867,-0.3891484207838882,0.011628382363652217,-0.544579561175527,1.3064533352461962,0.011628382363652217,-0.12957783544472734,0.5271655315673739,0.011628382363652217,0.6452247828693638,0.1808662269600239,0.3107081753546436,-0.5842434527420278,-0.5052379861113006,-0.3510973783434665,0.8153380062854007,0.011628382363652217,1.0041412915640857,2.5096531511230316,0.3107081753546436,0.7312880952006297,-0.23888251175943867,1.107748671810519,0.6160723009781515,0.011628382363652217,1.0303233973076291,-1.445023740434061,-1.3531728506809722,2.5096531511230316,-0.7461197124067016,-0.23888251175943867,0.9511996966722966,0.7312880952006297,-0.5052379861113006,0.759523653936807,0.49703301170235065,-0.023187036139176026,1.330541201726474,0.6452247828693638,0.3107081753546436,0.6452247828693638,-0.023187036139176026,0.21377219628069816,3.102383344071522,0.3107081753546436,-1.3989382867201257,-0.2021240853281833
2,631
Phase i functionalization of compounds
6
12
2.302133
0.021328
P11766,Q16850,O43169,O00170,P30837,P07099
Processes and pathways
Reactome Pathways
msigdb_reactome
596,202,329,417,56,25
417,329,1492,621,25,1717,596,830,1345,56,1267,202
0.759523653936807,0.8702994873684097,-0.09379028637419248,0.5570467687489573,3.0124937225901696,-0.2759642918046235,0.5866809767008758,0.3739010427175194,0.011628382363652217,2.06688635784378,0.08028608865991266,1.107748671810519
2,631
Pcp ce pathway
13
47
2.290889
0.02197
P28072,P07737,O00233,O00487,Q9UL46,P25789,P28074,P25788,P49721,P49720,Q99436,P20618,P28070
Processes and pathways
Reactome Pathways
msigdb_reactome
34,191,132,188,206,350,106,349,18,142,394,59,62
515,874,132,188,2627,1843,825,929,1394,191,1444,1445,59,1011,749,349,350,973,62,34,106,1893,1115,1066,142,18,1894,1408,2073,378,937,1858,1257,1593,2109,1777,1930,1068,1416,941,1507,943,1742,394,2091,206,922
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-5.876800338851456,-0.3891484207838882,0.3739010427175194,0.3107081753546436,-0.023187036139176026,1.13319242501366,-0.058326639732175146,-0.058326639732175146,2.0274549169815406,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.4275222886859329,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,-0.023187036139176026,-0.624229536412293,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,-0.6645376888850335,-0.31336929154874354,-0.46621885306434724,0.21377219628069816,-0.023187036139176026,0.3107081753546436,-0.09379028637419248,0.3107081753546436,-0.2759642918046235,0.8153380062854007,-0.624229536412293,1.107748671810519,0.3424442560190503
2,631
Pteridine containing compound metabolic process
7
17
2.290836
0.021973
P09417,Q9NRN7,Q99707,Q9H2D1,P00374,P41440,P34897
Processes and pathways
GO Biological process
msigdb_gobp
369,131,169,130,9,49,371
9,1993,369,1849,1341,1157,1405,371,2339,49,600,1548,505,1031,169,130,131
4.004804150480747,-0.544579561175527,0.8153380062854007,-0.3891484207838882,0.011628382363652217,0.14765384784078572,-0.023187036139176026,0.8153380062854007,-1.041784332284214,2.2016422601947694,0.5866809767008758,-0.12957783544472734,0.6741423628769925,0.24637748849157123,1.2084658865131082,1.330541201726474,1.330541201726474
2,631
Coated vesicle
23
81
2.274954
0.022909
P42892,Q15363,Q9P253,P02786,P49755,Q9NR31,Q9Y3A6,Q15437,Q9Y282,Q12907,Q9Y3B3,O43731,Q15436,Q9Y6B6,Q9Y678,Q9BVK6,P10321,O95070,Q5VW38,P49257,Q96RQ1,Q8N511,P24390
Localization
GO Cellular component
msigdb_gocc
245,5,272,264,143,412,416,22,29,422,53,54,61,82,230,102,347,105,385,234,393,121,123
1436,1951,1384,2627,788,2329,1846,54,1756,1004,1617,1803,2566,1758,1394,1244,105,2101,264,793,1444,347,2334,2035,494,2037,123,1254,245,1500,234,143,2273,498,2466,1819,1205,2141,1354,1408,1678,532,797,1777,1930,1120,422,1784,980,1072,1074,5,61,22,1788,385,1545,121,2160,1466,2088,1742,393,102,612,1228,459,412,1945,272,555,1380,1044,2195,29,416,53,1329,230,82,1045
-0.058326639732175146,-0.5052379861113006,-0.023187036139176026,-5.876800338851456,0.40508352216113896,-1.041784332284214,-0.3891484207838882,2.0864437380032115,-0.31336929154874354,0.24637748849157123,-0.2021240853281833,-0.3510973783434665,-2.022972918699234,-0.31336929154874354,-0.023187036139176026,0.08028608865991266,1.47179933358734,-0.6645376888850335,0.977767688006064,0.40508352216113896,-0.058326639732175146,0.8429236851350608,-1.041784332284214,-0.5842434527420278,0.6741423628769925,-0.5842434527420278,1.3544699048423925,0.08028608865991266,1.0041412915640857,-0.09379028637419248,1.0303233973076291,1.2822041225107923,-0.9131432773169984,0.6741423628769925,-1.3989382867201257,-0.3510973783434665,0.11412915938872559,-0.705167787937405,0.011628382363652217,-0.023187036139176026,-0.23888251175943867,0.6452247828693638,0.40508352216113896,-0.31336929154874354,-0.46621885306434724,0.1808662269600239,0.759523653936807,-0.31336929154874354,0.278687675691609,0.21377219628069816,0.21377219628069816,4.86328444949437,2.0274549169815406,3.1756606722953644,-0.31336929154874354,0.8153380062854007,-0.12957783544472734,1.3782415831495038,-0.705167787937405,-0.058326639732175146,-0.624229536412293,-0.2759642918046235,0.8153380062854007,1.4948164960337653,0.5866809767008758,0.11412915938872559,0.7312880952006297,0.7875391296424109,-0.46621885306434724,0.977767688006064,0.6452247828693638,0.011628382363652217,0.24637748849157123,-0.7461197124067016,2.841800548164946,0.7875391296424109,2.1058970915870394,0.04611947228614343,1.0563168307418604,1.6299370577151888,0.24637748849157123
2,631
Negative regulation of transporter activity
7
11
2.269509
0.023237
P30626,P78417,Q9UMX0,P28161,Q9HD26,P0DP25,P62942
Processes and pathways
GO Biological process
msigdb_gobp
163,236,415,336,459,151,60
1710,151,336,2039,163,720,60,236,448,459,415
-0.2759642918046235,1.257791335055367,0.8702994873684097,-0.5842434527420278,1.2084658865131082,0.46664484400905687,2.0274549169815406,1.0303233973076291,0.7312880952006297,0.7312880952006297,0.7875391296424109
2,631
Lysosome
17
43
2.261379
0.023736
P50897,P61421,P07602,P17900,P10619,Q93050,Q15904,P11117,Q9Y2T2,Q9Y487,O75503,Q9UMR5,Q9UJY5,P06865,Q8NCC3,P04066,P11717
Processes and pathways
KEGG Pathways
msigdb_kegg
314,167,310,563,493,146,145,141,197,260,331,156,487,276,27,150,494
1951,2595,1047,2165,1146,1756,331,1848,150,880,276,310,2032,1444,1248,493,141,1009,494,1058,1399,563,314,1354,2514,167,1631,1930,846,1824,1072,145,27,1426,146,1279,612,1478,2127,487,156,197,260
-0.5052379861113006,-2.4337795187306717,0.21377219628069816,-0.7461197124067016,0.14765384784078572,-0.31336929154874354,0.8702994873684097,-0.3891484207838882,1.257791335055367,0.3424442560190503,0.9511996966722966,0.8974686565746289,-0.5842434527420278,-0.058326639732175146,0.08028608865991266,0.6741423628769925,1.2822041225107923,0.24637748849157123,0.6741423628769925,0.21377219628069816,-0.023187036139176026,0.6160723009781515,0.8974686565746289,0.011628382363652217,-1.5851991561112928,1.2084658865131082,-0.2021240853281833,-0.46621885306434724,0.3739010427175194,-0.3510973783434665,0.21377219628069816,1.2822041225107923,2.9358813459906243,-0.023187036139176026,1.2822041225107923,0.08028608865991266,0.5866809767008758,-0.058326639732175146,-0.6645376888850335,0.7028288840536002,1.257791335055367,1.13319242501366,1.0041412915640857
2,631
Golgi membrane
41
104
2.249106
0.024506
Q15363,P40616,P11717,P49755,Q9H7Z7,P83436,P35670,Q9Y282,O43505,Q15392,Q8IV08,Q86Y82,P52292,Q12907,Q16799,Q9Y3B3,O43731,Q9HD26,Q15436,Q8NCH0,Q9H4A6,O00461,P36405,P08754,Q8WVM8,P60953,Q14789,O15498,Q9Y678,Q8NF37,P35613,Q9BVK6,L0R6Q1,P10321,O95070,P62820,P49257,Q9H8Y8,Q8NBN3,Q9BW83,P24390
Localization
GO Cellular component
msigdb_gocc
5,372,494,143,551,282,398,29,35,36,168,299,420,422,182,53,54,459,61,319,67,187,312,441,343,445,86,328,230,356,468,102,218,347,105,500,234,511,253,256,123
218,187,2595,788,2522,328,35,54,1756,1004,1803,1758,105,709,1150,1491,793,441,2068,347,1108,494,123,2202,1254,468,398,312,372,1534,1500,892,234,143,2273,2466,2274,420,896,1205,2141,936,445,1411,1896,532,797,500,2494,282,603,846,687,422,1784,1072,86,631,2540,5,1122,36,61,1459,182,2484,2316,299,168,2549,1828,253,319,356,813,987,343,1276,1466,1560,1703,102,256,612,1229,67,551,511,2298,459,1834,2434,1188,555,997,2489,1044,675,29,821,2217,962,53,230
1.0563168307418604,1.13319242501366,-2.4337795187306717,0.40508352216113896,-1.6325636329473232,0.8702994873684097,2.5269915348506964,2.0864437380032115,-0.31336929154874354,0.24637748849157123,-0.3510973783434665,-0.31336929154874354,1.47179933358734,0.46664484400905687,0.14765384784078572,-0.09379028637419248,0.40508352216113896,0.7312880952006297,-0.624229536412293,0.8429236851350608,0.1808662269600239,0.6741423628769925,1.3544699048423925,-0.7873933421725157,0.08028608865991266,0.7028288840536002,0.7875391296424109,0.8974686565746289,0.8153380062854007,-0.12957783544472734,-0.09379028637419248,0.3424442560190503,1.0303233973076291,1.2822041225107923,-0.9131432773169984,-1.3989382867201257,-0.9131432773169984,0.759523653936807,0.3424442560190503,0.11412915938872559,-0.705167787937405,0.3107081753546436,0.7312880952006297,-0.023187036139176026,-0.4275222886859329,0.6452247828693638,0.40508352216113896,0.6741423628769925,-1.4914291062743523,0.9511996966722966,0.5866809767008758,0.3739010427175194,0.49703301170235065,0.759523653936807,-0.31336929154874354,0.21377219628069816,1.5854529614565336,0.5570467687489573,-1.7765736441710231,4.86328444949437,0.1808662269600239,2.5096531511230316,2.0274549169815406,-0.058326639732175146,1.15845820052481,-1.445023740434061,-0.9985829370388538,0.9244343611620436,1.2084658865131082,-1.874176461311327,-0.3510973783434665,1.0041412915640857,0.8974686565746289,0.8429236851350608,0.40508352216113896,0.278687675691609,0.8702994873684097,0.08028608865991266,-0.058326639732175146,-0.12957783544472734,-0.23888251175943867,1.4948164960337653,1.0041412915640857,0.5866809767008758,0.11412915938872559,1.865329260145266,0.6452247828693638,0.6741423628769925,-0.9557025473106139,0.7312880952006297,-0.3510973783434665,-1.26260245787533,0.14765384784078572,0.6452247828693638,0.278687675691609,-1.445023740434061,0.24637748849157123,0.5271655315673739,2.841800548164946,0.40508352216113896,-0.7873933421725157,0.3107081753546436,2.1058970915870394,1.0563168307418604
2,631
Nadh dehydrogenase activity
7
17
2.248031
0.024574
O96000,Q16718,O75306,O95831,O95168,O43676,O43674
Functions
GO Molecular function
msigdb_gomf
275,450,219,46,289,262,119
966,119,262,466,219,1194,289,2031,1151,46,275,1578,714,450,1689,1094,1664
0.278687675691609,1.3782415831495038,0.977767688006064,0.7028288840536002,1.0563168307418604,0.11412915938872559,0.9244343611620436,-0.5842434527420278,0.14765384784078572,2.239250199852926,0.9511996966722966,-0.16568914771639728,0.46664484400905687,0.7312880952006297,-0.23888251175943867,0.21377219628069816,-0.2021240853281833
2,631
Lipid droplet
6
26
2.239421
0.025129
Q99720,Q8NF37,P48449,Q01105,Q8N0X7,Q8NBX0
Localization
GO Cellular component
msigdb_gocc
0,356,8,200,388,154
395,1333,1990,1713,1715,1492,2102,1531,8,1204,1117,2466,1895,200,1634,804,388,577,154,356,1276,2261,0,1185,1095,1663
0.7875391296424109,0.011628382363652217,-0.544579561175527,-0.2759642918046235,-0.2759642918046235,-0.09379028637419248,-0.6645376888850335,-0.12957783544472734,4.016404489026196,0.11412915938872559,0.1808662269600239,-1.3989382867201257,-0.4275222886859329,1.107748671810519,-0.2021240853281833,0.40508352216113896,0.8153380062854007,0.6160723009781515,1.257791335055367,0.8429236851350608,0.08028608865991266,-0.8709052422195689,5.562677407182912,0.14765384784078572,0.21377219628069816,-0.2021240853281833
2,631
Neurotransmitter transport
9
23
2.238709
0.025175
P50897,P49841,Q9P253,Q99808,P54920,P35080,P41440,P0DP25,O14936
Processes and pathways
GO Biological process
msigdb_gobp
314,351,272,74,292,291,49,151,149
587,1142,1048,149,680,1491,2066,151,1401,2037,291,49,351,314,292,757,448,2049,941,1825,1911,74,272
0.5866809767008758,0.14765384784078572,0.21377219628069816,1.257791335055367,0.49703301170235065,-0.09379028637419248,-0.624229536412293,1.257791335055367,-0.023187036139176026,-0.5842434527420278,0.9244343611620436,2.2016422601947694,0.8429236851350608,0.8974686565746289,0.9244343611620436,0.4359965476908903,0.7312880952006297,-0.5842434527420278,0.3107081753546436,-0.3510973783434665,-0.4275222886859329,1.7602151237227783,0.977767688006064
2,631
Intra golgi and retrograde golgi to er traffic
26
77
2.238295
0.025202
Q15363,P40616,P11717,P49755,P83436,Q9UBF2,O43264,P43034,P54920,Q13561,Q9Y3B3,O43731,P18085,Q9BUF5,O00461,O75935,Q5VZE5,Q9H2M9,O15498,Q10472,Q9Y678,Q9BVK6,P52732,Q14964,P62820,P24390
Processes and pathways
Reactome Pathways
msigdb_reactome
5,372,494,143,282,555,395,526,292,423,53,54,179,457,187,75,607,614,328,603,230,102,235,631,500,123
1916,1567,187,328,2331,395,1846,54,1004,1713,1758,75,1395,1150,1491,494,179,123,2071,2202,1254,372,526,1675,1064,1500,143,235,1536,1205,2141,292,1162,797,500,1778,282,2276,1121,603,847,801,1784,2205,849,423,662,1684,2402,2234,631,763,5,1459,1216,607,1547,1828,1464,1276,1981,1087,693,457,989,102,1562,614,1185,1322,1188,555,1324,53,2129,230,2521
-0.46621885306434724,-0.16568914771639728,1.13319242501366,0.8702994873684097,-1.041784332284214,0.7875391296424109,-0.3891484207838882,2.0864437380032115,0.24637748849157123,-0.2759642918046235,-0.31336929154874354,1.7173052362630885,-0.023187036139176026,0.14765384784078572,-0.09379028637419248,0.6741423628769925,1.15845820052481,1.3544699048423925,-0.624229536412293,-0.7873933421725157,0.08028608865991266,0.8153380062854007,0.6452247828693638,-0.23888251175943867,0.21377219628069816,-0.09379028637419248,1.2822041225107923,1.0303233973076291,-0.12957783544472734,0.11412915938872559,-0.705167787937405,0.9244343611620436,0.14765384784078572,0.40508352216113896,0.6741423628769925,-0.31336929154874354,0.9511996966722966,-0.9131432773169984,0.1808662269600239,0.5866809767008758,0.3739010427175194,0.40508352216113896,-0.31336929154874354,-0.7873933421725157,0.3739010427175194,0.759523653936807,0.5271655315673739,-0.23888251175943867,-1.17331342279577,-0.8289885581393346,0.5570467687489573,0.4359965476908903,4.86328444949437,-0.058326639732175146,0.11412915938872559,0.5866809767008758,-0.12957783544472734,-0.3510973783434665,-0.058326639732175146,0.08028608865991266,-0.5052379861113006,0.21377219628069816,0.49703301170235065,0.7312880952006297,0.278687675691609,1.4948164960337653,-0.12957783544472734,0.5866809767008758,0.14765384784078572,0.04611947228614343,0.14765384784078572,0.6452247828693638,0.04611947228614343,2.1058970915870394,-0.6645376888850335,1.0563168307418604,-1.5851991561112928
2,631
Insulin receptor recycling
6
10
2.235333
0.025395
P21281,P61421,Q93050,Q15904,P36543,Q9Y487
Processes and pathways
Reactome Pathways
msigdb_reactome
222,167,146,145,337,260
222,335,337,597,167,145,146,2127,260,1141
1.0563168307418604,0.8702994873684097,0.8702994873684097,0.5866809767008758,1.2084658865131082,1.2822041225107923,1.2822041225107923,-0.6645376888850335,1.0041412915640857,0.1808662269600239
2,631
Receptor
6
31
2.225769
0.02603
Q99720,Q8WTV0,Q9NS69,O43731,Q9Y2I1,P24390
Functions
Protein Atlas Molecular function
protein_atlas_molecular_function
0,10,185,54,228,123
556,1144,2165,439,54,264,2066,1107,1806,1443,2225,1009,494,1850,2376,123,468,1165,1541,1072,1365,2483,10,1649,1223,0,185,228,2372,1328,1002
0.6160723009781515,0.14765384784078572,-0.7461197124067016,0.7312880952006297,2.0864437380032115,0.977767688006064,-0.624229536412293,0.1808662269600239,-0.3510973783434665,-0.058326639732175146,-0.8289885581393346,0.24637748849157123,0.6741423628769925,-0.3891484207838882,-1.129149687086767,1.3544699048423925,0.7028288840536002,0.14765384784078572,-0.12957783544472734,0.21377219628069816,0.011628382363652217,-1.445023740434061,3.9225804558905155,-0.2021240853281833,0.11412915938872559,5.562677407182912,1.15845820052481,1.0563168307418604,-1.085306619758222,0.04611947228614343,0.278687675691609
2,631
Regulation of macroautophagy
16
43
2.219276
0.026468
P21281,P09601,P61421,P08754,Q8WVM8,P38606,Q93050,Q9UMX0,P27361,P36543,Q9H2M9,P21796,Q9UPT5,Q9NRR5,Q9Y487,P21283
Processes and pathways
GO Biological process
msigdb_gobp
222,311,167,441,343,597,146,415,419,337,614,85,585,117,260,335
1331,2165,1711,1758,620,1621,1848,2102,1106,1805,441,311,1920,1197,222,335,85,419,337,597,1534,838,167,1122,1645,343,146,1033,2056,614,1230,1477,117,1189,2127,415,1879,585,1950,962,260,1141,1287
0.011628382363652217,-0.7461197124067016,-0.2759642918046235,-0.31336929154874354,0.5570467687489573,-0.2021240853281833,-0.3891484207838882,-0.6645376888850335,0.1808662269600239,-0.3510973783434665,0.7312880952006297,0.8974686565746289,-0.46621885306434724,0.11412915938872559,1.0563168307418604,0.8702994873684097,1.5854529614565336,0.759523653936807,0.8702994873684097,0.5866809767008758,-0.12957783544472734,0.3739010427175194,1.2084658865131082,0.1808662269600239,-0.2021240853281833,0.8702994873684097,1.2822041225107923,0.24637748849157123,-0.5842434527420278,0.5866809767008758,0.11412915938872559,-0.058326639732175146,1.4018583320651603,0.14765384784078572,-0.6645376888850335,0.7875391296424109,-0.3891484207838882,0.6160723009781515,-0.46621885306434724,0.3107081753546436,1.0041412915640857,0.1808662269600239,0.08028608865991266
2,631
golgi
18
56
2.217819
0.026567
O15127,P40616,Q8WVM8,O14976,P20338,P54920,Q15904,P49755,Q5VW38,P36543,Q9Y6B6,Q8NBN3,Q8IXU6,Q15437,P18085,Q9Y487,Q9Y678,Q15436
Localization
OpenCell Localization
opencell_localization
189,372,343,364,162,292,145,143,385,337,82,253,21,22,179,260,230,61
2579,1710,364,2329,189,2522,2463,1244,2134,1444,179,162,1254,337,372,143,896,2141,1678,292,1411,1896,797,500,1930,1120,1860,1784,1074,61,22,145,385,1868,21,1828,253,343,1276,1700,1705,614,511,412,1834,2434,672,555,997,783,675,962,2425,260,230,82
-2.174637720685144,-0.2759642918046235,0.8153380062854007,-1.041784332284214,1.13319242501366,-1.6325636329473232,-1.3989382867201257,0.08028608865991266,-0.705167787937405,-0.058326639732175146,1.15845820052481,1.2084658865131082,0.08028608865991266,0.8702994873684097,0.8153380062854007,1.2822041225107923,0.3424442560190503,-0.705167787937405,-0.23888251175943867,0.9244343611620436,-0.023187036139176026,-0.4275222886859329,0.40508352216113896,0.6741423628769925,-0.46621885306434724,0.1808662269600239,-0.3891484207838882,-0.31336929154874354,0.21377219628069816,2.0274549169815406,3.1756606722953644,1.2822041225107923,0.8153380062854007,-0.3891484207838882,3.2189420102262942,-0.3510973783434665,1.0041412915640857,0.8702994873684097,0.08028608865991266,-0.23888251175943867,-0.23888251175943867,0.5866809767008758,0.6741423628769925,0.7875391296424109,-0.3510973783434665,-1.26260245787533,0.5271655315673739,0.6452247828693638,0.278687675691609,0.4359965476908903,0.5271655315673739,0.3107081753546436,-1.217797716297186,1.0041412915640857,1.0563168307418604,1.6299370577151888
2,631
Detoxification
13
28
2.217621
0.026581
Q8TC12,P35754,P21266,P30041,P30048,P08183,P11766,P00374,Q6DKJ4,Q16881,P78417,P28161,P35670
Processes and pathways
GO Biological process
msigdb_gobp
451,497,523,370,525,622,596,9,341,575,236,336,398
2063,644,9,930,1398,622,1532,596,747,523,336,370,1581,525,890,398,497,236,1969,575,341,451,1978,1911,1132,1318,1744,1753
-0.624229536412293,0.5271655315673739,4.004804150480747,0.3107081753546436,-0.023187036139176026,0.5570467687489573,-0.12957783544472734,0.5866809767008758,0.4359965476908903,0.6452247828693638,0.8702994873684097,0.8153380062854007,-0.16568914771639728,0.6452247828693638,0.3424442560190503,0.7875391296424109,0.6741423628769925,1.0303233973076291,-0.5052379861113006,0.6160723009781515,0.8702994873684097,0.7312880952006297,-0.5052379861113006,-0.4275222886859329,0.1808662269600239,0.04611947228614343,-0.2759642918046235,-0.2759642918046235
2,631
Negative regulation of ion transport
8
13
2.216385
0.026665
P30626,P78417,Q9UMX0,P28161,P21796,Q9HD26,P0DP25,P62942
Processes and pathways
GO Biological process
msigdb_gobp
163,236,415,336,85,459,151,60
1710,2374,151,85,336,2039,163,720,60,236,448,459,415
-0.2759642918046235,-1.129149687086767,1.257791335055367,1.5854529614565336,0.8702994873684097,-0.5842434527420278,1.2084658865131082,0.46664484400905687,2.0274549169815406,1.0303233973076291,0.7312880952006297,0.7312880952006297,0.7875391296424109
2,631
Negative regulation of ion transmembrane transport
8
13
2.216385
0.026665
P30626,P78417,Q9UMX0,P28161,P21796,Q9HD26,P0DP25,P62942
Processes and pathways
GO Biological process
msigdb_gobp
163,236,415,336,85,459,151,60
1710,2374,151,85,336,2039,163,720,60,236,448,459,415
-0.2759642918046235,-1.129149687086767,1.257791335055367,1.5854529614565336,0.8702994873684097,-0.5842434527420278,1.2084658865131082,0.46664484400905687,2.0274549169815406,1.0303233973076291,0.7312880952006297,0.7312880952006297,0.7875391296424109
2,631
Pten regulation
17
58
2.196675
0.028044
P28072,O00233,O00487,Q9UL46,P25789,P28074,P25788,Q6IAA8,P49721,P27361,P49720,Q99436,Q9Y2Q5,O00231,P20618,P60900,P28070
Processes and pathways
Reactome Pathways
msigdb_reactome
34,132,188,206,350,106,349,477,18,419,142,394,96,515,59,378,62
515,874,132,188,1843,825,517,929,2451,879,1106,1445,59,1011,749,349,350,419,973,62,34,106,1721,835,1893,1534,1115,1066,142,18,1894,2073,378,937,1858,1257,1593,1208,1068,1416,2482,1507,943,1418,1122,477,2209,770,2498,1129,814,394,2091,698,206,820,922,96
0.6452247828693638,0.3424442560190503,1.3064533352461962,1.13319242501366,-0.3891484207838882,0.3739010427175194,0.6452247828693638,0.3107081753546436,-1.3531728506809722,0.3424442560190503,0.1808662269600239,-0.058326639732175146,2.0274549169815406,0.24637748849157123,0.4359965476908903,0.8429236851350608,0.8429236851350608,0.759523653936807,0.278687675691609,2.007578507508111,2.561425042425346,1.47179933358734,-0.2759642918046235,0.3739010427175194,-0.4275222886859329,-0.12957783544472734,0.1808662269600239,0.21377219628069816,1.2822041225107923,3.3458384043052356,-0.4275222886859329,-0.624229536412293,0.8153380062854007,0.3107081753546436,-0.3891484207838882,0.08028608865991266,-0.16568914771639728,0.11412915938872559,0.21377219628069816,-0.023187036139176026,-1.445023740434061,-0.09379028637419248,0.3107081753546436,-0.023187036139176026,0.1808662269600239,0.7028288840536002,-0.7873933421725157,0.4359965476908903,-1.4914291062743523,0.1808662269600239,0.40508352216113896,0.8153380062854007,-0.624229536412293,0.49703301170235065,1.107748671810519,0.40508352216113896,0.3424442560190503,1.5176885982704214
2,631
Disproportionate short stature
7
17
2.195976
0.028094
Q15392,Q6DKJ4,Q32P28,Q9UHX1,Q9UBM7,Q96EX3,O75718
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
36,341,296,513,23,322,158
1527,557,2348,158,1338,1399,1533,1534,1500,1365,2234,36,296,341,322,23,513
-0.12957783544472734,0.6160723009781515,-1.085306619758222,1.2332126975583004,0.011628382363652217,-0.023187036139176026,-0.12957783544472734,-0.12957783544472734,-0.09379028637419248,0.011628382363652217,-0.8289885581393346,2.5096531511230316,0.9244343611620436,0.8702994873684097,0.8974686565746289,3.102383344071522,0.6741423628769925
2,631
transporter
13
50
2.194085
0.028229
O60684,Q9H2D1,O43772,Q92973,Q99808,Q9Y619,Q96P70,P41440,Q9UI26,O60830,Q99595,Q99805,P52294
Functions
Panther Protein class
panther_protein_class
94,130,3,100,74,47,175,49,52,231,115,26,159
824,2595,925,590,1802,1146,3,94,231,593,1007,2002,399,49,892,2586,420,159,2230,2427,2628,977,978,533,1598,1266,2363,298,854,1081,1029,857,481,100,1554,175,1376,115,26,74,1318,1227,130,1039,670,258,52,961,2324,47
0.3739010427175194,-2.4337795187306717,0.3107081753546436,0.5866809767008758,-0.3510973783434665,0.14765384784078572,4.963710030498427,1.5176885982704214,1.0303233973076291,0.5866809767008758,0.24637748849157123,-0.544579561175527,0.7875391296424109,2.2016422601947694,0.3424442560190503,-2.2258296179446355,0.759523653936807,1.2332126975583004,-0.8289885581393346,-1.26260245787533,-6.23222396242902,0.278687675691609,0.278687675691609,0.6452247828693638,-0.16568914771639728,0.08028608865991266,-1.085306619758222,0.9244343611620436,0.3739010427175194,0.21377219628069816,0.24637748849157123,0.3739010427175194,0.7028288840536002,1.4948164960337653,-0.12957783544472734,1.183548528852841,0.011628382363652217,1.4018583320651603,3.0124937225901696,1.7602151237227783,0.04611947228614343,0.11412915938872559,1.330541201726474,0.24637748849157123,0.5271655315673739,1.0041412915640857,2.163644168156307,0.3107081753546436,-0.9985829370388538,2.2204944858377984
2,631
Complex i biogenesis
9
23
2.193858
0.028246
O96000,Q9NPL8,Q9BQ95,Q16718,O75306,O95168,O43676,Q7L592,O43674
Processes and pathways
Reactome Pathways
msigdb_reactome
275,433,304,450,219,289,262,81,119
119,262,466,219,1194,289,2031,1151,275,1578,714,450,1689,81,1937,1602,304,1133,956,433,2265,1094,1664
1.3782415831495038,0.977767688006064,0.7028288840536002,1.0563168307418604,0.11412915938872559,0.9244343611620436,-0.5842434527420278,0.14765384784078572,0.9511996966722966,-0.16568914771639728,0.46664484400905687,0.7312880952006297,-0.23888251175943867,1.6299370577151888,-0.46621885306434724,-0.16568914771639728,0.9244343611620436,0.1808662269600239,0.3107081753546436,0.759523653936807,-0.8709052422195689,0.21377219628069816,-0.2021240853281833
2,631