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5731c904b9d445190005e552
Antibiotics
For example, an antibiotic target may be absent from the bacterial genome.
What can be absent from the bacterial genome?
{ "text": [ "antibiotic target" ], "answer_start": [ 16 ] }
5731c904b9d445190005e553
Antibiotics
The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange.
When does the spread of antibacterial resistance frequently occurs/
{ "text": [ "vertical transmission" ], "answer_start": [ 60 ] }
5733c3f34776f419006611d4
Antibiotics
Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA.
What does some resistance come from?
{ "text": [ "mutation" ], "answer_start": [ 35 ] }
5733c3f34776f419006611d5
Antibiotics
The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange.
What method of spread can occur in antibacterial resistance?
{ "text": [ "vertical transmission of mutations" ], "answer_start": [ 60 ] }
5733c3f34776f419006611d6
Antibiotics
Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials.
What do plasmids do in resistance?
{ "text": [ "carry several different resistance genes" ], "answer_start": [ 14 ] }
5733c4ca4776f419006611e4
Antibiotics
Antibacterial-resistant strains and species, sometimes referred to as "superbugs", now contribute to the emergence of diseases that were for a while well controlled.
What are strains that are resistant to antibiotics called sometimes?
{ "text": [ "superbugs" ], "answer_start": [ 71 ] }
5733c4ca4776f419006611e5
Antibiotics
For example, emergent bacterial strains causing tuberculosis (TB) that are resistant to previously effective antibacterial treatments pose many therapeutic challenges.
What was a once almost controlled disease that is coming back do to resistance?
{ "text": [ "tuberculosis" ], "answer_start": [ 48 ] }
5733c4ca4776f419006611e6
Antibiotics
Every year, nearly half a million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide.
How many new infections of resistant TB are reported per year?
{ "text": [ "half a million" ], "answer_start": [ 19 ] }
5733c4ca4776f419006611e7
Antibiotics
Every year, nearly half a million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide.
What is the acronym used to describe resistant TB?
{ "text": [ "MDR-TB" ], "answer_start": [ 81 ] }
5733c6d84776f41900661208
Antibiotics
Inappropriate antibiotic treatment and overuse of antibiotics have contributed to the emergence of antibiotic-resistant bacteria.
What are the two biggest reasons for resistance?
{ "text": [ "Inappropriate antibiotic treatment and overuse" ], "answer_start": [ 0 ] }
5733c6d84776f41900661209
Antibiotics
Self prescription of antibiotics is an example of misuse.
What is a common method of misuse?
{ "text": [ "Self prescription" ], "answer_start": [ 0 ] }
5733c6d84776f4190066120a
Antibiotics
The overuse of antibiotics, like penicillin and erythromycin, has been associated with emerging antibiotic resistance since the 1950s.
What is an example of bad treatment causing resistance?
{ "text": [ "overuse of antibiotics" ], "answer_start": [ 4 ] }
5733c81c4776f4190066121c
Antibiotics
Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers and failure of medical professionals to prescribe the correct dosage of antibiotics on the basis of the patient's weight and history of prior use.
What is a way of improperly using antibiotics for those traveling?
{ "text": [ "prophylactic antibiotics" ], "answer_start": [ 59 ] }
5733c81c4776f4190066121d
Antibiotics
Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers and failure of medical professionals to prescribe the correct dosage of antibiotics on the basis of the patient's weight and history of prior use.
What can happen if a doctor doesn't prescribe to a person's weight and prior use?
{ "text": [ "failure of medical professionals to prescribe the correct dosage" ], "answer_start": [ 101 ] }
5733c81c4776f4190066121e
Antibiotics
Other forms of misuse include failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery.
What are 3 other common forms of bad antibiotic practices?
{ "text": [ "failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery" ], "answer_start": [ 30 ] }
5733c81c4776f4190066121f
Antibiotics
Inappropriate antibiotic treatment, for example, is their prescription to treat viral infections such as the common cold.
What happens when a cold is treated with antibiotics?
{ "text": [ "Inappropriate antibiotic treatment" ], "answer_start": [ 0 ] }
5733c81c4776f41900661220
Antibiotics
One study on respiratory tract infections found "physicians were more likely to prescribe antibiotics to patients who appeared to expect them".
What do doctors usually do when a patient seems to want antibiotics even though they may not be right?
{ "text": [ "prescribe antibiotics" ], "answer_start": [ 80 ] }
5733cb484776f41900661256
Antibiotics
The issues of misuse and overuse of antibiotics have been addressed by the formation of the US Interagency Task Force on Antimicrobial Resistance.
What is the name of a US government agency tasked with trying to stop improper use of antibiotics?
{ "text": [ "US Interagency Task Force on Antimicrobial Resistance" ], "answer_start": [ 92 ] }
5733cb484776f41900661257
Antibiotics
This task force aims to actively address antimicrobial resistance, and is coordinated by the US Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and the National Institutes of Health (NIH), as well as other US agencies.
Which agencies control this task force?
{ "text": [ "US Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and the National Institutes of Health (NIH)" ], "answer_start": [ 93 ] }
5733cb484776f41900661258
Antibiotics
In France, an "Antibiotics are not automatic" government campaign started in 2002 and led to a marked reduction of unnecessary antibiotic prescriptions, especially in children.
When did the French start going after overuse of antibiotics?
{ "text": [ "2002" ], "answer_start": [ 77 ] }
5733cd2bd058e614000b62b3
Antibiotics
The emergence of antibiotic resistance has prompted restrictions on their use in the UK in 1970 (Swann report 1969), and the EU has banned the use of antibiotics as growth-promotional agents since 2003.
When did the EU ban antibiotics for speeding up growth?
{ "text": [ "2003" ], "answer_start": [ 197 ] }
5733cd2bd058e614000b62b4
Antibiotics
The emergence of antibiotic resistance has prompted restrictions on their use in the UK in 1970 (Swann report 1969), and the EU has banned the use of antibiotics as growth-promotional agents since 2003.
What report caused the UK to worry about resistance?
{ "text": [ "Swann report 1969" ], "answer_start": [ 97 ] }
5733cd2bd058e614000b62b5
Antibiotics
Moreover, several organizations (e.g., The American Society for Microbiology (ASM), American Public Health Association (APHA) and the American Medical Association (AMA)) have called for restrictions on antibiotic use in food animal production and an end to all nontherapeutic uses.[citation needed] However, commonly the...
What 3 US organizations have called for the banning of antibiotics in the production of food animals?
{ "text": [ "American Society for Microbiology (ASM), American Public Health Association (APHA) and the American Medical Association (AMA)" ], "answer_start": [ 43 ] }
5733cd2bd058e614000b62b6
Antibiotics
Two federal bills (S.742 and H.R. 2562) aimed at phasing out nontherapeutic use of antibiotics in US food animals were proposed, but have not passed.
Name two US bills that want to ban antibiotics in food production?
{ "text": [ "S.742 and H.R. 2562" ], "answer_start": [ 19 ] }
5733cd2bd058e614000b62b7
Antibiotics
These bills were endorsed by public health and medical organizations, including the American Holistic Nurses' Association, the American Medical Association, and the American Public Health Association (APHA).
What 3 medical associations supported the bills?
{ "text": [ "American Holistic Nurses' Association, the American Medical Association, and the American Public Health Association (APHA)" ], "answer_start": [ 84 ] }
5733d178d058e614000b6321
Antibiotics
There has been extensive use of antibiotics in animal husbandry.
What besides sick people are antibiotics used for?
{ "text": [ "animal husbandry" ], "answer_start": [ 47 ] }
5733d178d058e614000b6322
Antibiotics
In the United States, the question of emergence of antibiotic-resistant bacterial strains due to use of antibiotics in livestock was raised by the US Food and Drug Administration (FDA) in 1977.
When was resistance first discussed as a problem in the raising of farm animals?
{ "text": [ "1977" ], "answer_start": [ 188 ] }
5733d178d058e614000b6323
Antibiotics
In March 2012, the United States District Court for the Southern District of New York, ruling in an action brought by the Natural Resources Defense Council and others, ordered the FDA to revoke approvals for the use of antibiotics in livestock, which violated FDA regulations.
When did a district court order the FDA to stop approving antibiotics in animals?
{ "text": [ "March 2012" ], "answer_start": [ 3 ] }
5733d2444776f419006612d8
Antibiotics
Before the early 20th century, treatments for infections were based primarily on medicinal folklore.
What methods did people use before antibiotics to treat infections?
{ "text": [ "medicinal folklore" ], "answer_start": [ 81 ] }
5733d2444776f419006612d9
Antibiotics
Mixtures with antimicrobial properties that were used in treatments of infections were described over 2000 years ago.
When were some kinds of antimicrobials first used?
{ "text": [ "over 2000 years ago" ], "answer_start": [ 97 ] }
5733d2444776f419006612da
Antibiotics
Many ancient cultures, including the ancient Egyptians and ancient Greeks, used specially selected mold and plant materials and extracts to treat infections.
What type of things did Egyptians and Greeks use?
{ "text": [ "mold and plant materials and extracts" ], "answer_start": [ 99 ] }
5733d2444776f419006612db
Antibiotics
The term 'antibiosis', meaning "against life", was introduced by the French bacteriologist Jean Paul Vuillemin as a descriptive name of the phenomenon exhibited by these early antibacterial drugs.
What does antibiosis mean?
{ "text": [ "against life" ], "answer_start": [ 32 ] }
5733d2444776f419006612dc
Antibiotics
The term 'antibiosis', meaning "against life", was introduced by the French bacteriologist Jean Paul Vuillemin as a descriptive name of the phenomenon exhibited by these early antibacterial drugs.
Who came up with the term antibiosis?
{ "text": [ "Jean Paul Vuillemin" ], "answer_start": [ 91 ] }
5733d3334776f419006612e2
Antibiotics
The effects of some types of mold on infection had been noticed many times over the course of history (see: History of penicillin).
What type of organism has been reported to have worked on infections?
{ "text": [ "mold" ], "answer_start": [ 29 ] }
5733d3334776f419006612e3
Antibiotics
In 1928, Alexander Fleming noticed the same effect in a Petri dish, where a number of disease-causing bacteria were killed by a fungus of the genus Penicillium.
Who noticed in a lab the antibacterial characteristics of mold?
{ "text": [ "Alexander Fleming" ], "answer_start": [ 9 ] }
5733d3334776f419006612e4
Antibiotics
Fleming postulated that the effect is mediated by an antibacterial compound he named penicillin, and that its antibacterial properties could be exploited for chemotherapy.
What mold did Fleming notice had antibacterial properties?
{ "text": [ "penicillin" ], "answer_start": [ 85 ] }
5733d3334776f419006612e5
Antibiotics
Fleming postulated that the effect is mediated by an antibacterial compound he named penicillin, and that its antibacterial properties could be exploited for chemotherapy.
What did Fleming initially think a good use would be for it?
{ "text": [ "chemotherapy" ], "answer_start": [ 158 ] }
5733d4364776f419006612f2
Antibiotics
The first sulfonamide and first commercially available antibacterial, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 at the Bayer Laboratories of the IG Farben conglomerate in Germany.
What was the first available antibiotic?
{ "text": [ "Prontosil" ], "answer_start": [ 70 ] }
5733d4364776f419006612f3
Antibiotics
The first sulfonamide and first commercially available antibacterial, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 at the Bayer Laboratories of the IG Farben conglomerate in Germany.
What company developed Prontosil?
{ "text": [ "IG Farben" ], "answer_start": [ 177 ] }
5733d4364776f419006612f4
Antibiotics
The first sulfonamide and first commercially available antibacterial, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 at the Bayer Laboratories of the IG Farben conglomerate in Germany.
Who led the team that came up with Prontosil?
{ "text": [ "Gerhard Domagk" ], "answer_start": [ 121 ] }
5733d4364776f419006612f5
Antibiotics
Domagk received the 1939 Nobel Prize for Medicine for his efforts.
What prize did Domagk get for his work?
{ "text": [ "1939 Nobel Prize for Medicine" ], "answer_start": [ 20 ] }
5733d4c24776f41900661304
Antibiotics
In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20% gramicidin and 80% tyrocidine, from B. brevis.
What was the first antibiotic developed from nature?
{ "text": [ "tyrothricin" ], "answer_start": [ 129 ] }
5733d4c24776f41900661305
Antibiotics
In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20% gramicidin and 80% tyrocidine, from B. brevis.
When was tyrothricin created?
{ "text": [ "1939" ], "answer_start": [ 3 ] }
5733d4c24776f41900661306
Antibiotics
In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20% gramicidin and 80% tyrocidine, from B. brevis.
What also happened in 1939 besides tyrothricin?
{ "text": [ "start of World War II," ], "answer_start": [ 29 ] }
5733d4c24776f41900661307
Antibiotics
In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20% gramicidin and 80% tyrocidine, from B. brevis.
Who discovered tyrothricin?
{ "text": [ "Rene Dubos" ], "answer_start": [ 52 ] }
5733d4c24776f41900661308
Antibiotics
It was one of the first commercially manufactured antibiotics universally and was very effective in treating wounds and ulcers during World War II.
What was tyrothricin used for during the war?
{ "text": [ "wounds and ulcers" ], "answer_start": [ 109 ] }
5733d5f24776f41900661314
Antibiotics
Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945.
When was penicillin G first purified?
{ "text": [ "1942" ], "answer_start": [ 79 ] }
5733d5f24776f41900661315
Antibiotics
Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945.
When did penicillin G become available outside of military use?
{ "text": [ "1945" ], "answer_start": [ 159 ] }
5733d5f24776f41900661316
Antibiotics
Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk.
Who came up with a way to quickly produce penicillin?
{ "text": [ "Norman Heatley" ], "answer_start": [ 7 ] }
5733d5f24776f41900661317
Antibiotics
The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945.
When was the chemical make-up of penicillin discovered?
{ "text": [ "1945" ], "answer_start": [ 83 ] }
5733d5f24776f41900661318
Antibiotics
The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945.
Who discovered the chemical structure of penicillin?
{ "text": [ "Dorothy Crowfoot Hodgkin" ], "answer_start": [ 55 ] }
5733d670d058e614000b6379
Antibiotics
Vaccines rely on immune modulation or augmentation.
What do vaccines need to work?
{ "text": [ "immune modulation or augmentation" ], "answer_start": [ 17 ] }
5733d670d058e614000b637a
Antibiotics
Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases.
What type of vaccines have saved millions of lives?
{ "text": [ "Antibacterial vaccines" ], "answer_start": [ 0 ] }
5733d670d058e614000b637b
Antibiotics
Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.
What types of vaccines have been phased out?
{ "text": [ "Vaccines made from attenuated whole cells or lysates" ], "answer_start": [ 0 ] }
5733d6e64776f41900661328
Antibiotics
Phage therapy is another option that is being looked into for treating resistant strains of bacteria.
What has been talked about to treat resistant bacteria?
{ "text": [ "Phage therapy" ], "answer_start": [ 0 ] }
5733d6e64776f41900661329
Antibiotics
The way that researchers are doing this is by infecting pathogenic bacteria with their own viruses, more specifically, bacteriophages.
How have researchers been doing this?
{ "text": [ "infecting pathogenic bacteria" ], "answer_start": [ 46 ] }
5733d6e64776f4190066132a
Antibiotics
One of the worries about using phages to fight pathogens is that the phages will infect "good" bacteria, or the bacteria that are important in the everyday function of human beings.
What is a worry of using phages?
{ "text": [ "phages will infect \"good\" bacteria" ], "answer_start": [ 69 ] }
5733d88b4776f41900661344
Antibiotics
Since 2009, only 2 new antibiotics were approved in the United States.
How many antibiotics have been created in the last 7 years?
{ "text": [ "2" ], "answer_start": [ 17 ] }
5733d88b4776f41900661345
Antibiotics
The report identified seven antibiotics against the Gram-negative bacilli (GNB) currently in phase 2 or phase 3 clinical trials.
How many are in the pipelin to fight GNB?
{ "text": [ "seven" ], "answer_start": [ 22 ] }
5733d88b4776f41900661346
Antibiotics
In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance.
What year did the Infectious Disease Society of America say that production of new antibiotics does not keep up with resistance?
{ "text": [ "2013" ], "answer_start": [ 9 ] }
5733d91e4776f4190066134a
Antibiotics
Possible improvements include clarification of clinical trial regulations by FDA.
Who regulates antibiotic approval?
{ "text": [ "FDA" ], "answer_start": [ 77 ] }
5733d91e4776f4190066134b
Antibiotics
Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor.
What could help to spur pharmaceuticals to make new antibiotics?
{ "text": [ "economic incentives" ], "answer_start": [ 25 ] }
5733d91e4776f4190066134c
Antibiotics
Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing threat of 'superbugs'.
What are resistant bacteria called in the media?
{ "text": [ "superbugs" ], "answer_start": [ 137 ] }
5733d91e4776f4190066134d
Antibiotics
According to Allan Coukell, senior director for health programs at The Pew Charitable Trusts, "By allowing drug developers to rely on smaller datasets, and clarifying FDA's authority to tolerate a higher level of uncertainty for these drugs when making a risk/benefit calculation, ADAPT would make the clinical trials mo...
Who is a director at the Pew Charitable Trusts?
{ "text": [ "Allan Coukell," ], "answer_start": [ 13 ] }
56cbd2356d243a140015ed6a
Frédéric_Chopin
A child prodigy, he completed his musical education and composed his earlier works in Warsaw before leaving Poland at the age of 20, less than a month before the outbreak of the November 1830 Uprising.
At what age did Frédéric depart from Poland?
{ "text": [ "20" ], "answer_start": [ 129 ] }
56ce0a3762d2951400fa69da
Frédéric_Chopin
A child prodigy, he completed his musical education and composed his earlier works in Warsaw before leaving Poland at the age of 20, less than a month before the outbreak of the November 1830 Uprising.
At what age did Chopin leave Poland?
{ "text": [ "20" ], "answer_start": [ 129 ] }
56d1ca30e7d4791d009021a9
Frédéric_Chopin
A child prodigy, he completed his musical education and composed his earlier works in Warsaw before leaving Poland at the age of 20, less than a month before the outbreak of the November 1830 Uprising.
How old was Chopin when he left Poland?
{ "text": [ "20" ], "answer_start": [ 129 ] }
56cbd2f96d243a140015ed70
Frédéric_Chopin
At the age of 21 he settled in Paris.
At what age did Frédéric move to Paris?
{ "text": [ "21" ], "answer_start": [ 14 ] }
56cbd2f96d243a140015ed71
Frédéric_Chopin
Thereafter, during the last 18 years of his life, he gave only some 30 public performances, preferring the more intimate atmosphere of the salon.
How many public performances was Frédéric estimated to have given during the remainder of his life?
{ "text": [ "30" ], "answer_start": [ 68 ] }
56cbd2f96d243a140015ed72
Frédéric_Chopin
In 1835 he obtained French citizenship.
In what year did Frédéric obtain citizenship in France?
{ "text": [ "1835" ], "answer_start": [ 3 ] }
56cbd2f96d243a140015ed73
Frédéric_Chopin
A brief and unhappy visit to Majorca with Sand in 1838–39 was one of his most productive periods of composition.
In what area had Frédéric's most productive period of composition taken place?
{ "text": [ "Majorca" ], "answer_start": [ 29 ] }
56cbd2f96d243a140015ed74
Frédéric_Chopin
He died in Paris in 1849, probably of tuberculosis.
What was Frédéric's most likely cause of death?
{ "text": [ "tuberculosis" ], "answer_start": [ 38 ] }
56ce0d8662d2951400fa69e8
Frédéric_Chopin
At the age of 21 he settled in Paris.
Where did he end up living when he was 21?
{ "text": [ "Paris" ], "answer_start": [ 31 ] }
56ce0d8662d2951400fa69e9
Frédéric_Chopin
Thereafter, during the last 18 years of his life, he gave only some 30 public performances, preferring the more intimate atmosphere of the salon.
How many public shows did he perform during the last years of his life?
{ "text": [ "30" ], "answer_start": [ 68 ] }
56ce0d8662d2951400fa69ea
Frédéric_Chopin
Chopin formed a friendship with Franz Liszt and was admired by many of his musical contemporaries, including Robert Schumann.
What other composer did Chopin develop a friendship with?
{ "text": [ "Franz Liszt" ], "answer_start": [ 32 ] }
56ce0d8662d2951400fa69eb
Frédéric_Chopin
In 1835 he obtained French citizenship.
What year did he gain citizenship in France?
{ "text": [ "1835" ], "answer_start": [ 3 ] }
56ce0d8662d2951400fa69ec
Frédéric_Chopin
After a failed engagement to Maria Wodzińska, from 1837 to 1847 he maintained an often troubled relationship with the French writer George Sand.
What is the name of the woman he had a relationship with from 1837-847?
{ "text": [ "Maria Wodzińska" ], "answer_start": [ 29 ] }
56cf5734aab44d1400b89079
Frédéric_Chopin
At the age of 21 he settled in Paris.
At what age did Chopin move to Paris?
{ "text": [ "21" ], "answer_start": [ 14 ] }
56cf5734aab44d1400b8907a
Frédéric_Chopin
Thereafter, during the last 18 years of his life, he gave only some 30 public performances, preferring the more intimate atmosphere of the salon.
During the last 18 years he lived about how many times did Chopin perform in public?
{ "text": [ "30" ], "answer_start": [ 68 ] }
56cf5734aab44d1400b8907c
Frédéric_Chopin
In 1835 he obtained French citizenship.
What year did Chopin become a citizen of France?
{ "text": [ "1835" ], "answer_start": [ 3 ] }
56cf5734aab44d1400b8907d
Frédéric_Chopin
In his last years, he was financially supported by his admirer Jane Stirling, who also arranged for him to visit Scotland in 1848.
In the last years of his life who was the person that supported him financially?
{ "text": [ "Jane Stirling" ], "answer_start": [ 63 ] }
56d1cd98e7d4791d009021e6
Frédéric_Chopin
In 1835 he obtained French citizenship.
In what year did Chopin become a French citizen?
{ "text": [ "1835" ], "answer_start": [ 3 ] }
56d1cd98e7d4791d009021e7
Frédéric_Chopin
In his last years, he was financially supported by his admirer Jane Stirling, who also arranged for him to visit Scotland in 1848.
Who gave Chopin money in the last years of his life?
{ "text": [ "Jane Stirling" ], "answer_start": [ 63 ] }
56d1cd98e7d4791d009021e8
Frédéric_Chopin
He died in Paris in 1849, probably of tuberculosis.
What was the likely cause of death for Chopin?
{ "text": [ "tuberculosis" ], "answer_start": [ 38 ] }
56cbd4c56d243a140015ed7a
Frédéric_Chopin
All of Chopin's compositions include the piano. Most are for solo piano, though he also wrote two piano concertos, a few chamber pieces, and some songs to Polish lyrics.
What instrument did every composition by Frédéric include?
{ "text": [ "piano" ], "answer_start": [ 41 ] }
56cbd4c56d243a140015ed7b
Frédéric_Chopin
Chopin invented the concept of instrumental ballade.
What concept was Frédéric credited with creating?
{ "text": [ "instrumental ballade" ], "answer_start": [ 31 ] }
56cbd4c56d243a140015ed7c
Frédéric_Chopin
Influences on his compositional style include Polish folk music, the classical tradition of J. S. Bach, Mozart and Schubert, the music of all of whom he admired, as well as the Paris salons where he was a frequent guest. His innovations in style, musical form, and harmony, and his association of music with nationalism,...
Whose music did Frédéric admire the most and thus provide influence on his work?
{ "text": [ "J. S. Bach, Mozart and Schubert" ], "answer_start": [ 92 ] }
56cbd4c56d243a140015ed7d
Frédéric_Chopin
His keyboard style is highly individual and often technically demanding; his own performances were noted for their nuance and sensitivity.
What features marked Frédéric's performance style and made them unique?
{ "text": [ "nuance and sensitivity" ], "answer_start": [ 115 ] }
56cbd4c56d243a140015ed7e
Frédéric_Chopin
Influences on his compositional style include Polish folk music, the classical tradition of J. S. Bach, Mozart and Schubert, the music of all of whom he admired, as well as the Paris salons where he was a frequent guest. His innovations in style, musical form, and harmony, and his association of music with nationalism,...
What establishments did Frédéric frequently visit in Paris that influenced his career?
{ "text": [ "Paris salons" ], "answer_start": [ 177 ] }
56ce0f42aab44d1400b8841e
Frédéric_Chopin
All of Chopin's compositions include the piano. Most are for solo piano, though he also wrote two piano concertos, a few chamber pieces, and some songs to Polish lyrics.
Which instrument do every one of his compositions include?
{ "text": [ "piano" ], "answer_start": [ 41 ] }
56ce0f42aab44d1400b8841f
Frédéric_Chopin
Chopin invented the concept of instrumental ballade.
What concept did Chopin create?
{ "text": [ "instrumental ballade" ], "answer_start": [ 31 ] }
56ce0f42aab44d1400b88420
Frédéric_Chopin
His keyboard style is highly individual and often technically demanding; his own performances were noted for their nuance and sensitivity.
What are two things Chopin's performances were known for?
{ "text": [ "nuance and sensitivity" ], "answer_start": [ 115 ] }
56ce0f42aab44d1400b88421
Frédéric_Chopin
Influences on his compositional style include Polish folk music, the classical tradition of J. S. Bach, Mozart and Schubert, the music of all of whom he admired, as well as the Paris salons where he was a frequent guest. His innovations in style, musical form, and harmony, and his association of music with nationalism,...
What three composers influenced Chopin's work?
{ "text": [ "J. S. Bach, Mozart and Schubert" ], "answer_start": [ 92 ] }
56ce0f42aab44d1400b88422
Frédéric_Chopin
All of Chopin's compositions include the piano. Most are for solo piano, though he also wrote two piano concertos, a few chamber pieces, and some songs to Polish lyrics.
Chopin wrote some music to lyrics, what language were the lyrics?
{ "text": [ "Polish" ], "answer_start": [ 155 ] }
56cf582eaab44d1400b8909b
Frédéric_Chopin
All of Chopin's compositions include the piano. Most are for solo piano, though he also wrote two piano concertos, a few chamber pieces, and some songs to Polish lyrics.
What instrument is involved in all of Chopin's work?
{ "text": [ "piano" ], "answer_start": [ 41 ] }
56cf582eaab44d1400b8909c
Frédéric_Chopin
All of Chopin's compositions include the piano. Most are for solo piano, though he also wrote two piano concertos, a few chamber pieces, and some songs to Polish lyrics.
Chopin composed several songs to lyrics of what language?
{ "text": [ "Polish" ], "answer_start": [ 155 ] }
56cf582eaab44d1400b8909d
Frédéric_Chopin
His keyboard style is highly individual and often technically demanding; his own performances were noted for their nuance and sensitivity.
Chopin's performances were known for what?
{ "text": [ "nuance and sensitivity" ], "answer_start": [ 115 ] }
56cf582eaab44d1400b8909e
Frédéric_Chopin
Influences on his compositional style include Polish folk music, the classical tradition of J. S. Bach, Mozart and Schubert, the music of all of whom he admired, as well as the Paris salons where he was a frequent guest. His innovations in style, musical form, and harmony, and his association of music with nationalism,...
What three composers did Chopin take inspiration from?
{ "text": [ "J. S. Bach, Mozart and Schubert" ], "answer_start": [ 92 ] }
56d1cf80e7d4791d00902211
Frédéric_Chopin
All of Chopin's compositions include the piano. Most are for solo piano, though he also wrote two piano concertos, a few chamber pieces, and some songs to Polish lyrics.
What instrument was all of Chopin's compositions written for?
{ "text": [ "piano" ], "answer_start": [ 41 ] }
56d1cf80e7d4791d00902212
Frédéric_Chopin
All of Chopin's compositions include the piano. Most are for solo piano, though he also wrote two piano concertos, a few chamber pieces, and some songs to Polish lyrics.
What language were some songs written in that Chopin wrote music for?
{ "text": [ "Polish" ], "answer_start": [ 155 ] }