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Severe thrombocytopenia and haemolytic anaemia associated with ciprofloxacin: a case report with fatal outcome. Haematological adverse reactions associated with fatal outcome are rare during treatment with ciprofloxacin. A 30 - year old Caucasian man reported with abdominal pain and jaundice after 3 - day administratio... | {
"entities": {
"chemical": [
{
"text": "ciprofloxacin",
"start": 63,
"end": 76
},
{
"text": "ciprofloxacin",
"start": 206,
"end": 219
},
{
"text": "ciprofloxacin",
"start": 330,
"end": 343
},
{
... | [] |
Simvastatin - induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism. A 54 - year - old hypothyroid male taking thyroxine and simvastatin presented with bilateral leg compartment syndrome and myonecrosis. Urgent fasciotomies were performed and the patient made an uneventful recovery w... | {
"entities": {
"chemical": [
{
"text": "Simvastatin",
"start": 0,
"end": 11
},
{
"text": "thyroxine",
"start": 147,
"end": 156
},
{
"text": "simvastatin",
"start": 161,
"end": 172
},
{
"text"... | [] |
Bile duct hamartoma occurring in association with long - term treatment with danazol. We report a case of bile duct hamartoma which developed in a patient who had been on long - term danazol treatment. Such patients should be under close follow - up, preferably with periodic ultrasound examination of the liver. If the ... | {
"entities": {
"chemical": [
{
"text": "danazol",
"start": 77,
"end": 84
},
{
"text": "danazol",
"start": 183,
"end": 190
}
],
"disease": [
{
"text": "Bile duct hamartoma",
"start": 0,
"end": 19
},... | [] |
Granulomatous hepatitis due to combination of amoxicillin and clavulanic acid. We report the case of a patient with amoxicillin - clavulanic acid - induced hepatitis with histologic multiple granulomas. This type of lesion broadens the spectrum of liver injury due to this drug combination, mainly represented by a benig... | {
"entities": {
"chemical": [
{
"text": "combination of amoxicillin and clavulanic acid",
"start": 31,
"end": 77
},
{
"text": "amoxicillin - clavulanic acid",
"start": 116,
"end": 145
},
{
"text": "penicillin",
"start": ... | [] |
Intracranial aneurysms and cocaine abuse: analysis of prognostic indicators. OBJECTIVE: The outcome of subarachnoid hemorrhage associated with cocaine abuse is reportedly poor. However, no study in the literature has reported the use of a statistical model to analyze the variables that influence outcome. METHODS: A rev... | {
"entities": {
"chemical": [
{
"text": "cocaine",
"start": 389,
"end": 396
},
{
"text": "cocaine",
"start": 1295,
"end": 1302
},
{
"text": "Cocaine",
"start": 1336,
"end": 1343
}
],
"disease": [
... | [] |
Anti - epileptic drugs - induced de novo absence seizures. The authors present three patients with de novo absence epilepsy after administration of carbamazepine and vigabatrin. Despite the underlying diseases, the prognosis for drug - induced de novo absence seizure is good because it subsides rapidly after discontinu... | {
"entities": {
"chemical": [
{
"text": "carbamazepine",
"start": 148,
"end": 161
},
{
"text": "vigabatrin",
"start": 166,
"end": 176
},
{
"text": "gamma - aminobutyric acid",
"start": 360,
"end": 385
}
... | [] |
Procainamide - induced polymorphous ventricular tachycardia. Seven cases of procainamide - induced polymorphous ventricular tachycardia are presented. In four patients, polymorphous ventricular tachycardia appeared after intravenous administration of 200 to 400 mg of procainamide for the treatment of sustained ventricu... | {
"entities": {
"chemical": [
{
"text": "Procainamide",
"start": 0,
"end": 12
},
{
"text": "procainamide",
"start": 76,
"end": 88
},
{
"text": "procainamide",
"start": 268,
"end": 280
},
{
"te... | [] |
Role of activation of bradykinin B2 receptors in disruption of the blood - brain barrier during acute hypertension. Cellular mechanisms which account for disruption the blood - brain barrier during acute hypertension are not clear. The goal of this study was to determine the role of synthesis / release of bradykinin to... | {
"entities": {
"chemical": [
{
"text": "bradykinin",
"start": 22,
"end": 32
},
{
"text": "bradykinin",
"start": 307,
"end": 317
},
{
"text": "dextran",
"start": 509,
"end": 516
},
{
"text": "... | [] |
5 - azacytidine potentiates initiation induced by carcinogens in rat liver. To test the validity of the hypothesis that hypomethylation of DNA plays an important role in the initiation of carcinogenic process, 5 - azacytidine (5 - AzC) (10 mg / kg), an inhibitor of DNA methylation, was given to rats during the phase of... | {
"entities": {
"chemical": [
{
"text": "5 - azacytidine",
"start": 0,
"end": 15
},
{
"text": "5 - azacytidine",
"start": 210,
"end": 225
},
{
"text": "5 - AzC",
"start": 227,
"end": 234
},
{
... | [] |
Withdrawal - emergent rabbit syndrome during dose reduction of risperidone. Rabbit syndrome (RS) is a rare extrapyramidal side effect caused by prolonged neuroleptic medication. Here we present a case of withdrawal - emergent RS, which is the first of its kind to be reported. The patient developed RS during dose reduct... | {
"entities": {
"chemical": [
{
"text": "risperidone",
"start": 63,
"end": 74
},
{
"text": "risperidone",
"start": 327,
"end": 338
},
{
"text": "trihexyphenidyl",
"start": 382,
"end": 397
},
{
... | [] |
Verapamil withdrawal as a possible cause of myocardial infarction in a hypertensive woman with a normal coronary angiogram. Verapamil is an effective and relatively - safe antihypertensive drug. Serious adverse effects are uncommon and mainly have been related to the depression of cardiac contractility and conduction, ... | {
"entities": {
"chemical": [
{
"text": "Verapamil",
"start": 0,
"end": 9
},
{
"text": "Verapamil",
"start": 124,
"end": 133
},
{
"text": "captopril",
"start": 469,
"end": 478
},
{
"text": "ve... | [] |
Remission induction of meningeal leukemia with high - dose intravenous methotrexate. Twenty children with acute lymphoblastic leukemia who developed meningeal disease were treated with a high - dose intravenous methotrexate regimen that was designed to achieve and maintain CSF methotrexate concentrations of 10 (- 5) mo... | {
"entities": {
"chemical": [
{
"text": "methotrexate",
"start": 71,
"end": 83
},
{
"text": "methotrexate",
"start": 211,
"end": 223
},
{
"text": "methotrexate",
"start": 278,
"end": 290
},
{
... | [] |
Hypersensitivity to carbamazepine presenting with a leukemoid reaction, eosinophilia, erythroderma, and renal failure. We report a patient in whom hypersensitivity to carbamazepine presented with generalized erythroderma, a severe leukemoid reaction, eosinophilia, hyponatremia, and renal failure. This is the first repo... | {
"entities": {
"chemical": [
{
"text": "carbamazepine",
"start": 20,
"end": 33
},
{
"text": "carbamazepine",
"start": 167,
"end": 180
},
{
"text": "carbamazepine",
"start": 354,
"end": 367
}
],
"di... | [] |
The interpeduncular nucleus regulates nicotine' s effects on free - field activity. Partial lesions were made with kainic acid in the interpeduncular nucleus of the ventral midbrain of the rat. Compared with sham - operated controls, lesions significantly (p < 0. 25) blunted the early (< 60 min) free - field locomotor ... | {
"entities": {
"chemical": [
{
"text": "nicotine",
"start": 38,
"end": 46
},
{
"text": "kainic acid",
"start": 115,
"end": 126
},
{
"text": "nicotine",
"start": 343,
"end": 351
},
{
"text": "... | [] |
Assessment of a new non - invasive index of cardiac performance for detection of dobutamine - induced myocardial ischemia. BACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine - induced myocardial ischemia. OBJECTIVES: To assess the added diagnostic value of a new cardiac performance index... | {
"entities": {
"chemical": [
{
"text": "dobutamine",
"start": 81,
"end": 91
},
{
"text": "dobutamine",
"start": 195,
"end": 205
},
{
"text": "dobutamine",
"start": 439,
"end": 449
},
{
"text"... | [] |
Acute liver failure in two patients with regular alcohol consumption ingesting paracetamol at therapeutic dosage. BACKGROUND: The possible role of alcohol in the development of hepatotoxicity associated with therapeutic doses of paracetamol (acetaminophen) is currently debated. CASE REPORT: We describe 2 patients who w... | {
"entities": {
"chemical": [
{
"text": "alcohol",
"start": 49,
"end": 56
},
{
"text": "paracetamol",
"start": 79,
"end": 90
},
{
"text": "alcohol",
"start": 147,
"end": 154
},
{
"text": "para... | [] |
Cocaine related chest pain: are we seeing the tip of an iceberg? The recreational use of cocaine is on the increase. The emergency nurse ought to be familiar with some of the cardiovascular consequences of cocaine use. In particular, the tendency of cocaine to produce chest pain ought to be in the mind of the emergency... | {
"entities": {
"chemical": [
{
"text": "Cocaine",
"start": 0,
"end": 7
},
{
"text": "cocaine",
"start": 89,
"end": 96
},
{
"text": "cocaine",
"start": 206,
"end": 213
},
{
"text": "cocaine",
... | [] |
Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir. OBJECTIVE: To report a case of a severe interaction between simvastatin, amiodarone, and atazanavir resulting in rhabdomyolysis and acute renal failure. BACKGROUND: A 72 - year - old white man with und... | {
"entities": {
"chemical": [
{
"text": "simvastatin",
"start": 78,
"end": 89
},
{
"text": "amiodarone",
"start": 91,
"end": 101
},
{
"text": "atazanavir",
"start": 107,
"end": 117
},
{
"text"... | [] |
Phase II trial of vinorelbine in metastatic squamous cell esophageal carcinoma. European Organization for Research and Treatment of Cancer Gastrointestinal Treat Cancer Cooperative Group. PURPOSE: To evaluate the response rate and toxic effects of vinorelbine (VNB) administered as a single agent in metastatic squamous ... | {
"entities": {
"chemical": [
{
"text": "vinorelbine",
"start": 18,
"end": 29
},
{
"text": "vinorelbine",
"start": 248,
"end": 259
},
{
"text": "VNB",
"start": 261,
"end": 264
},
{
"text": "ci... | [] |
Paclitaxel, cisplatin, and gemcitabine combination chemotherapy within a multidisciplinary therapeutic approach in metastatic nonsmall cell lung carcinoma. BACKGROUND: Cisplatin - based chemotherapy combinations improve quality of life and survival in advanced nonsmall cell lung carcinoma (NSCLC). The emergence of new ... | {
"entities": {
"chemical": [
{
"text": "Paclitaxel",
"start": 0,
"end": 10
},
{
"text": "cisplatin",
"start": 12,
"end": 21
},
{
"text": "gemcitabine",
"start": 27,
"end": 38
},
{
"text": "Ci... | [] |
Evaluation of adverse reactions of aponidine hydrochloride ophthalmic solution. We prospectively evaluated the adverse reactions of apraclonidine in 20 normal volunteers by instilling a single drop of 1% apraclonidine in their right eyes. Examinations, including blood pressure, pulse rate, conjunctiva and cornea, intra... | {
"entities": {
"chemical": [
{
"text": "aponidine hydrochloride",
"start": 35,
"end": 58
},
{
"text": "apraclonidine",
"start": 132,
"end": 145
},
{
"text": "apraclonidine",
"start": 204,
"end": 217
},
... | [] |
Carmofur - induced organic mental disorders. Organic mental disorder was observed in a 29 - year - old female in the prognostic period after the onset of carmofur - induced leukoencephalopathy. Symptoms such as euphoria, emotional lability and puerile attitude noted in the patient were diagnosed as organic personality ... | {
"entities": {
"chemical": [
{
"text": "Carmofur",
"start": 0,
"end": 8
},
{
"text": "carmofur",
"start": 154,
"end": 162
},
{
"text": "carmofur",
"start": 620,
"end": 628
}
],
"disease": [
{... | [] |
International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group. The antiarrhythmic effects of the sustained release form of mexiletine (Mexitil - Perlongets) were evaluated in a double - blind placebo trial in 630 patients with recent documented myo... | {
"entities": {
"chemical": [
{
"text": "mexiletine",
"start": 14,
"end": 24
},
{
"text": "mexiletine",
"start": 195,
"end": 205
},
{
"text": "Mexitil - Perlongets",
"start": 207,
"end": 227
},
{
... | [] |
Regional localization of the antagonism of amphetamine - induced hyperactivity by intracerebral calcitonin injections. Calcitonin receptors are found in the brain, and intracerebral infusions of calcitonin can produce behavioral effects. Among these behavioral effects are decreases in food intake and decreases in amphe... | {
"entities": {
"chemical": [
{
"text": "amphetamine",
"start": 43,
"end": 54
},
{
"text": "calcitonin",
"start": 96,
"end": 106
},
{
"text": "Calcitonin",
"start": 119,
"end": 129
},
{
"text"... | [] |
Fatal intracranial bleeding associated with prehospital use of epinephrine. We present a case of paramedic misjudgment in the execution of a protocol for the treatment of allergic reaction in a case of pulmonary edema with wheezing. The sudden onset of respiratory distress, rash, and a history of a new medicine led the... | {
"entities": {
"chemical": [
{
"text": "epinephrine",
"start": 63,
"end": 74
},
{
"text": "epinephrine",
"start": 376,
"end": 387
},
{
"text": "Epinephrine",
"start": 468,
"end": 479
}
],
"disease"... | [] |
A case of massive rhabdomyolysis following molindone administration. Rhabdomyolysis is a potentially lethal syndrome that psychiatric patients seem predisposed to develop. The clinical signs and symptoms, typical laboratory features, and complications of rhabdomyolysis are presented. The case of a schizophrenic patient... | {
"entities": {
"chemical": [
{
"text": "molindone",
"start": 43,
"end": 52
},
{
"text": "molindone",
"start": 415,
"end": 424
},
{
"text": "molindone",
"start": 466,
"end": 475
}
],
"disease": [
... | [] |
Cardiovascular alterations in rat fetuses exposed to calcium channel blockers. Preclinical toxicologic investigation suggested that a new calcium channel blocker, Ro 40 - 5967, induced cardiovascular alterations in rat fetuses exposed to this agent during organogenesis. The present study was designed to investigate the... | {
"entities": {
"chemical": [
{
"text": "calcium",
"start": 53,
"end": 60
},
{
"text": "calcium",
"start": 138,
"end": 145
},
{
"text": "Ro 40 - 5967",
"start": 163,
"end": 175
},
{
"text": "c... | [] |
Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine - resistant hepatitis B virus e antigen - positive and - negative strains. Immune escape variants of the hepatitis B virus (HBV) represent an emerging clinical challenge, because they can be associated with vaccine escape, H... | {
"entities": {
"chemical": [
{
"text": "lamivudine",
"start": 85,
"end": 95
},
{
"text": "hepatitis B virus e antigen",
"start": 108,
"end": 135
},
{
"text": "lamivudine",
"start": 781,
"end": 791
},
... | [] |
The effects of sevoflurane on lidocaine - induced convulsions. The influence of sevoflurane on lidocaine - induced convulsions was studied in cats. The convulsive threshold (mean + / - SD) was 41. 4 + / - 6. 5 mg. l (- 1) with lidocaine infusion (6 mg. kg (- 1). min (- 1)), increasing significantly to 66. 6 + / - 10. 9... | {
"entities": {
"chemical": [
{
"text": "sevoflurane",
"start": 15,
"end": 26
},
{
"text": "lidocaine",
"start": 30,
"end": 39
},
{
"text": "sevoflurane",
"start": 80,
"end": 91
},
{
"text": "... | [] |
Anti - oxidant effects of atorvastatin in dexamethasone - induced hypertension in the rat. 1. Dexamethasone (Dex) - induced hypertension is characterized by endothelial dysfunction associated with nitric oxide (NO) deficiency and increased superoxide (O2 -) production. Atorvastatin (Ato) possesses pleiotropic propertie... | {
"entities": {
"chemical": [
{
"text": "atorvastatin",
"start": 26,
"end": 38
},
{
"text": "dexamethasone",
"start": 42,
"end": 55
},
{
"text": "Dexamethasone",
"start": 94,
"end": 107
},
{
"... | [] |
99mTc - glucarate for detection of isoproterenol - induced myocardial infarction in rats. Infarct - avid radiopharmaceuticals are necessary for rapid and timely diagnosis of acute myocardial infarction. The animal model used to produce infarction implies artery ligation but chemical induction can be easily obtained wit... | {
"entities": {
"chemical": [
{
"text": "99mTc - glucarate",
"start": 0,
"end": 17
},
{
"text": "isoproterenol",
"start": 35,
"end": 48
},
{
"text": "isoproterenol",
"start": 322,
"end": 335
},
{
... | [] |
A randomized, placebo - controlled dose - comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer' s disease. OBJECTIVE: The goal of this study was to compare the efficacy and side effects of two doses of haloperidol and placebo in the treatment of psychosis and disruptive behaviors in patie... | {
"entities": {
"chemical": [
{
"text": "haloperidol",
"start": 62,
"end": 73
},
{
"text": "haloperidol",
"start": 233,
"end": 244
},
{
"text": "haloperidol",
"start": 448,
"end": 459
},
{
"te... | [] |
Individual differences in renal ACE activity in healthy rats predict susceptibility to adriamycin - induced renal damage. BACKGROUND: In man, differences in angiotensin - converting enzyme (ACE) levels, related to ACE (I / D) genotype, are associated with renal prognosis. This raises the hypothesis that individual diff... | {
"entities": {
"chemical": [
{
"text": "adriamycin",
"start": 87,
"end": 97
},
{
"text": "angiotensin",
"start": 157,
"end": 168
},
{
"text": "adriamycin",
"start": 540,
"end": 550
},
{
"text... | [] |
Clinical nephrotoxicity of tobramycin and gentamicin. A prospective study. Nearly 3. 2 million people in this country receive aminoglycoside antibiotics annually. Gentamicin sulfate and tobramycin sulfate continue to demonstrate ototoxicity and nephrotoxicity in both animal and clinical studies. In this study, 62 patie... | {
"entities": {
"chemical": [
{
"text": "tobramycin",
"start": 27,
"end": 37
},
{
"text": "gentamicin",
"start": 42,
"end": 52
},
{
"text": "aminoglycoside",
"start": 126,
"end": 140
},
{
"tex... | [] |
Neuroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine - induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats. The aim of this study was to examine the role of metabotropic glutamate receptor 5 (mGluR5) in the toxic action... | {
"entities": {
"chemical": [
{
"text": "MPEP",
"start": 26,
"end": 30
},
{
"text": "methamphetamine",
"start": 66,
"end": 81
},
{
"text": "dopamine",
"start": 152,
"end": 160
},
{
"text": "gl... | [] |
Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl. OBJECTIVE: In vitro work has demonstrated that cinacalcet is a strong inhibitor of cytochrome P450 isoenzyme (CYP) 2D6. The purpose of this study was to evaluate the effect of cinacalcet on CYP2D6 activity, using desipramine as a probe substrate... | {
"entities": {
"chemical": [
{
"text": "desipramine HCl",
"start": 20,
"end": 35
},
{
"text": "cinacalcet HCl",
"start": 59,
"end": 73
},
{
"text": "cinacalcet",
"start": 122,
"end": 132
},
{
... | [] |
Proteomic analysis of striatal proteins in the rat model of L - DOPA - induced dyskinesia. L - DOPA - induced dyskinesia (LID) is among the motor complications that arise in Parkinson' s disease (PD) patients after a prolonged treatment with L - DOPA. To this day, transcriptome analysis has been performed in a rat mode... | {
"entities": {
"chemical": [
{
"text": "L - DOPA",
"start": 60,
"end": 68
},
{
"text": "L - DOPA",
"start": 91,
"end": 99
},
{
"text": "L - DOPA",
"start": 242,
"end": 250
},
{
"text": "6 - h... | [] |
Pseudo - allergic reactions to corticosteroids: diagnosis and alternatives. Two patients treated with parenteral paramethasone (Triniol) and dexamethasone (Sedionbel) are described. A few minutes after administration of the drugs, they presented urticaria (patients 1 and 2) and conjunctivitis (patient 1). The purpose o... | {
"entities": {
"chemical": [
{
"text": "corticosteroids",
"start": 31,
"end": 46
},
{
"text": "paramethasone",
"start": 113,
"end": 126
},
{
"text": "dexamethasone",
"start": 141,
"end": 154
},
{
... | [] |
Valproic acid induced encephalopathy - - 19 new cases in Germany from 1994 to 2003 - - a side effect associated to VPA - therapy not only in young children. Valproic acid (VPA) is a broad - spectrum antiepileptic drug and is usually well - tolerated. Rare serious complications may occur in some patients, including haem... | {
"entities": {
"chemical": [
{
"text": "Valproic acid",
"start": 0,
"end": 13
},
{
"text": "VPA",
"start": 115,
"end": 118
},
{
"text": "Valproic acid",
"start": 157,
"end": 170
},
{
"text": ... | [] |
Haemolytic - uraemic syndrome after treatment with metronidazole. This paper describes the clinical features of six children who developed the haemolytic - uraemic syndrome after treatment with metronidazole. These children were older and were more likely to have undergone recent bowel surgery than are other children w... | {
"entities": {
"chemical": [
{
"text": "metronidazole",
"start": 51,
"end": 64
},
{
"text": "metronidazole",
"start": 194,
"end": 207
},
{
"text": "metronidazole",
"start": 365,
"end": 378
},
{
... | [] |
Risk factors of sensorineural hearing loss in preterm infants. Among 547 preterm infants of < or = 34 weeks gestation born between 1987 and 1991, 8 children (1. 46%) developed severe progressive and bilateral sensorineural hearing loss. Perinatal risk factors of infants with hearing loss were compared with those of two... | {
"entities": {
"chemical": [
{
"text": "aminoglycosides",
"start": 642,
"end": 657
},
{
"text": "furosemide",
"start": 662,
"end": 672
}
],
"disease": [
{
"text": "sensorineural hearing loss",
"start": 16,
... | [] |
Pharmacokinetic and clinical studies in patients with cimetidine - associated mental confusion. 15 cases of cimetidine - associated mental confusion have been reported. In order that this syndrome might be investigated changes in mental status (M. S.) were correlated with serum concentrations and renal and hepatic func... | {
"entities": {
"chemical": [
{
"text": "cimetidine",
"start": 54,
"end": 64
},
{
"text": "cimetidine",
"start": 108,
"end": 118
},
{
"text": "cimetidine",
"start": 376,
"end": 386
},
{
"text"... | [] |
Different lobular distributions of altered hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis. Hepatocyte tight junctions (TJs), the only intercellular barrier between the sinusoidal and the canalicular spaces, play a key role in bile formation. Although hepatocyte TJs are impaired in... | {
"entities": {
"chemical": [
{
"text": "ethinyl estradiol",
"start": 712,
"end": 729
},
{
"text": "EE",
"start": 731,
"end": 733
},
{
"text": "EE",
"start": 1372,
"end": 1374
},
{
"text": "EE... | [] |
Long term audiological evaluation of beta - thalassemic patients. OBJECTIVE: The objective of this study was to identify the incidence and to monitor the progression of hearing loss in children and young adults with beta - thalassemia major. METHODS: One hundred and four (104) patients aged 6 - 35 years (mean 17, 2 yea... | {
"entities": {
"chemical": [
{
"text": "desferrioxamine",
"start": 491,
"end": 506
},
{
"text": "DFO",
"start": 508,
"end": 511
},
{
"text": "DFO",
"start": 927,
"end": 930
},
{
"text": "DFO"... | [] |
Design and analysis of the HYPREN - trial: safety of enalapril and prazosin in the initial treatment phase of patients with congestive heart failure. Since the introduction of angiotensin converting enzyme (ACE) inhibitors into the adjunctive treatment of patients with congestive heart failure, cases of severe hypotens... | {
"entities": {
"chemical": [
{
"text": "enalapril",
"start": 53,
"end": 62
},
{
"text": "prazosin",
"start": 67,
"end": 75
},
{
"text": "angiotensin converting enzyme (ACE) inhibitors",
"start": 176,
"end": 222
... | [] |
Antagonism between interleukin 3 and erythropoietin in mice with azidothymidine - induced anemia and in bone marrow endothelial cells. Azidothymidine (AZT) - induced anemia in mice can be reversed by the administration of IGF - IL - 3 (fusion protein of insulin - like growth factor II (IGF II) and interleukin 3). Altho... | {
"entities": {
"chemical": [
{
"text": "azidothymidine",
"start": 65,
"end": 79
},
{
"text": "Azidothymidine",
"start": 135,
"end": 149
},
{
"text": "AZT",
"start": 151,
"end": 154
},
{
"text... | [] |
Interactive effects of variations in [Na] o and [Ca] o on rat atrial spontaneous frequency. The effects of varying the extracellular concentrations of Na and Ca ([Na] o and [Ca] o) on both, the spontaneous beating and the negative chronotropic action of verapamil, were studied in the isolated rat atria. Basal frequency... | {
"entities": {
"chemical": [
{
"text": "Na",
"start": 38,
"end": 40
},
{
"text": "Ca",
"start": 49,
"end": 51
},
{
"text": "Na",
"start": 151,
"end": 153
},
{
"text": "Ca",
"start": 1... | [] |
Sodium status influences chronic amphotericin B nephrotoxicity in rats. The nephrotoxic potential of amphotericin B (5 mg / kg per day intraperitoneally for 3 weeks) has been investigated in salt - depleted, normal - salt, and salt - loaded rats. In salt - depleted rats, amphotericin B decreased creatinine clearance li... | {
"entities": {
"chemical": [
{
"text": "Sodium",
"start": 0,
"end": 6
},
{
"text": "amphotericin B",
"start": 33,
"end": 47
},
{
"text": "amphotericin B",
"start": 101,
"end": 115
},
{
"text"... | [] |
Reversible inferior colliculus lesion in metronidazole - induced encephalopathy: magnetic resonance findings on diffusion - weighted and fluid attenuated inversion recovery imaging. OBJECTIVE: This is to present reversible inferior colliculus lesions in metronidazole - induced encephalopathy, to focus on the diffusion ... | {
"entities": {
"chemical": [
{
"text": "metronidazole",
"start": 41,
"end": 54
},
{
"text": "metronidazole",
"start": 254,
"end": 267
},
{
"text": "metronidazole",
"start": 519,
"end": 532
},
{
... | [] |
Comparison of the respiratory effects of i. v. infusions of morphine and regional analgesia by extradural block. The incidence of postoperative respiratory apnoea was compared between five patients receiving a continuous i. v. infusion of morphine (mean 73. 6 mg) and five patients receiving a continuous extradural infu... | {
"entities": {
"chemical": [
{
"text": "morphine",
"start": 60,
"end": 68
},
{
"text": "morphine",
"start": 239,
"end": 247
},
{
"text": "bupivacaine",
"start": 335,
"end": 346
},
{
"text": "... | [] |
Magnetic resonance volumetry of the cerebellum in epileptic patients after phenytoin overdosages. The aim of this study was to evaluate the relationship between phenytoin medication and cerebellar atrophy in patients who had experienced clinical intoxication. Five females and 6 males, 21 - 59 years of age, were examine... | {
"entities": {
"chemical": [
{
"text": "phenytoin",
"start": 75,
"end": 84
},
{
"text": "phenytoin",
"start": 161,
"end": 170
},
{
"text": "phenytoin",
"start": 1028,
"end": 1037
},
{
"text":... | [] |
Evaluation of cardiac troponin I and T levels as markers of myocardial damage in doxorubicin - induced cardiomyopathy rats, and their relationship with echocardiographic and histological findings. BACKGROUND: Cardiac troponins I (cTnI) and T (cTnT) have been shown to be highly sensitive and specific markers of myocardi... | {
"entities": {
"chemical": [
{
"text": "doxorubicin",
"start": 81,
"end": 92
},
{
"text": "doxorubicin",
"start": 447,
"end": 458
},
{
"text": "DOX",
"start": 460,
"end": 463
},
{
"text": "DO... | [] |
Calcineurin - inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantation. Bone pain after transplantation is a frequent complication that can be caused by several diseases. Treatment strategies depend on the correct diagnosis of the pain. Nine patients with severe pain in their ... | {
"entities": {
"chemical": [
{
"text": "cyclosporine",
"start": 823,
"end": 835
},
{
"text": "tacrolimus",
"start": 841,
"end": 851
},
{
"text": "calcium",
"start": 892,
"end": 899
},
{
"text... | [] |
The haemodynamic effects of propofol in combination with ephedrine in elderly patients (ASA groups 3 and 4). The marked vasodilator and negative inotropic effects of propofol are disadvantages in frail elderly patients. We investigated the safety and efficacy of adding different doses of ephedrine to propofol in order ... | {
"entities": {
"chemical": [
{
"text": "propofol",
"start": 28,
"end": 36
},
{
"text": "ephedrine",
"start": 57,
"end": 66
},
{
"text": "propofol",
"start": 166,
"end": 174
},
{
"text": "ephe... | [] |
Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan. An analysis is presented of 220 cases of possible neurotoxic reactions to halogenated hydroxyquinolines reported from outside Japan. In 80 cases insufficient information was available for adequate comment and in 29 a rela... | {
"entities": {
"chemical": [
{
"text": "halogenated hydroxyquinolines",
"start": 17,
"end": 46
},
{
"text": "halogenated hydroxyquinolines",
"start": 173,
"end": 202
},
{
"text": "clioquinol",
"start": 354,
"end... | [] |
Epileptic seizures following cortical application of fibrin sealants containing tranexamic acid in rats. BACKGROUND: Fibrin sealants (FS) derived from human plasma are frequently used in neurosurgery. In order to increase clot stability, FS typically contain aprotinin, a natural fibrinolysis inhibitor. Recently, synthe... | {
"entities": {
"chemical": [
{
"text": "tranexamic acid",
"start": 80,
"end": 95
},
{
"text": "tranexamic acid",
"start": 356,
"end": 371
},
{
"text": "tAMCA",
"start": 373,
"end": 378
},
{
"... | [] |
A diet promoting sugar dependency causes behavioral cross - sensitization to a low dose of amphetamine. Previous research in this laboratory has shown that a diet of intermittent excessive sugar consumption produces a state with neurochemical and behavioral similarities to drug dependency. The present study examined wh... | {
"entities": {
"chemical": [
{
"text": "amphetamine",
"start": 91,
"end": 102
},
{
"text": "amphetamine",
"start": 435,
"end": 446
},
{
"text": "sucrose",
"start": 609,
"end": 616
},
{
"text"... | [] |
D - penicillamine - induced angiopathy in rats. The effect of high dose D - penicillamine treatment on aortic permeability to albumin and on the ultrastructure of the vessel. Male Sprague - Dawley rats were treated with D - penicillamine (D - pen) 500 mg / kg / day for 10 or 42 days. Pair fed rats served as controls. C... | {
"entities": {
"chemical": [
{
"text": "D - penicillamine",
"start": 0,
"end": 17
},
{
"text": "D - penicillamine",
"start": 72,
"end": 89
},
{
"text": "D - penicillamine",
"start": 220,
"end": 237
},
... | [] |
Brain natriuretic peptide is a predictor of anthracycline - induced cardiotoxicity. Anthracyclines are effective antineoplastic drugs, but they frequently cause dose - related cardiotoxicity. The cardiotoxicity of conventional anthracycline therapy highlights a need to search for methods that are highly sensitive and c... | {
"entities": {
"chemical": [
{
"text": "anthracycline",
"start": 44,
"end": 57
},
{
"text": "Anthracyclines",
"start": 84,
"end": 98
},
{
"text": "anthracycline",
"start": 227,
"end": 240
},
{
... | [] |
Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. OBJECTIVE: To estimate the association between antibacterial medications and selected birth defects. DESIGN, SETTING, AND PARTICIPANTS: Population - based, multisite, case - control study of women who had p... | {
"entities": {
"chemical": [
{
"text": "Sulfonamides",
"start": 930,
"end": 942
},
{
"text": "Nitrofurantoins",
"start": 1348,
"end": 1363
},
{
"text": "erythromycins",
"start": 1704,
"end": 1717
},
... | [] |
Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens. Immunosuppressive drugs have been used during the last 30 years in treatment of patients with severe rheumatoid arthritis. The drugs commonly used are cyclophosphamide and chlorambucil (alkylating agents), azathioprine... | {
"entities": {
"chemical": [
{
"text": "cyclophosphamide",
"start": 253,
"end": 269
},
{
"text": "chlorambucil",
"start": 274,
"end": 286
},
{
"text": "alkylating agents",
"start": 288,
"end": 305
},
... | [] |
Patterns of hepatic injury induced by methyldopa. Twelve patients with liver disease related to methyldopa were seen between 1967 and 1977. Illness occurred within 1 - - 9 weeks of commencement of therapy in 9 patients, the remaining 3 patients having received the drug for 13 months, 15 months and 7 years before experi... | {
"entities": {
"chemical": [
{
"text": "methyldopa",
"start": 38,
"end": 48
},
{
"text": "methyldopa",
"start": 96,
"end": 106
},
{
"text": "methyldopa",
"start": 1078,
"end": 1088
},
{
"text... | [] |
A phase I / II study of paclitaxel plus cisplatin as first - line therapy for head and neck cancers: preliminary results. Improved outcomes among patients with head and neck carcinomas require investigations of new drugs for induction therapy. Preliminary results of an Eastern Cooperative Oncology Group study of single... | {
"entities": {
"chemical": [
{
"text": "paclitaxel",
"start": 24,
"end": 34
},
{
"text": "cisplatin",
"start": 40,
"end": 49
},
{
"text": "paclitaxel",
"start": 329,
"end": 339
},
{
"text": "... | [] |
A phase I study of 4' - 0 - tetrahydropyranyladriamycin. Clinical pharmacology and pharmacokinetics. A Phase I study of intravenous (IV) bolus 4' - 0 - tetrahydropyranyladriamycin (Pirarubicin) was done in 55 patients in good performance status with refractory tumors. Twenty - six had minimal prior therapy (good risk),... | {
"entities": {
"chemical": [
{
"text": "4' - 0 - tetrahydropyranyladriamycin",
"start": 19,
"end": 55
},
{
"text": "4' - 0 - tetrahydropyranyladriamycin",
"start": 143,
"end": 179
},
{
"text": "Pirarubicin",
"start": 18... | [] |
Differential effects of gamma - hexachlorocyclohexane (lindane) on pharmacologically - induced seizures. Gamma - hexachlorocyclohexane (gamma - HCH), the active ingredient of the insecticide lindane, has been shown to decrease seizure threshold to pentylenetrazol (PTZ) 3 h after exposure to gamma - HCH and conversely i... | {
"entities": {
"chemical": [
{
"text": "gamma - hexachlorocyclohexane",
"start": 24,
"end": 53
},
{
"text": "lindane",
"start": 55,
"end": 62
},
{
"text": "Gamma - hexachlorocyclohexane",
"start": 105,
"end": 13... | [] |
Severe ocular and orbital toxicity after intracarotid injection of carboplatin for recurrent glioblastomas. BACKGROUND: Glioblastoma is a malignant tumor that occurs in the cerebrum during adulthood. With current treatment regimens including combined surgery, radiation and chemotherapy, the average life expectancy of t... | {
"entities": {
"chemical": [
{
"text": "carboplatin",
"start": 67,
"end": 78
},
{
"text": "carboplatin",
"start": 505,
"end": 516
},
{
"text": "cisplatin",
"start": 558,
"end": 567
},
{
"text... | [] |
Phase II study of the amsacrine analogue CI - 921 (NSC 343499) in non - small cell lung cancer. CI - 921 (NSC 343499; 9 - [[2 - methoxy - 4 - [(methylsulphonyl) amino] phenyl] amino] - N, 5 - dimethyl - 4 - acridinecarboxamide) is a topoisomerase II poison with high experimental antitumour activity. It was administered... | {
"entities": {
"chemical": [
{
"text": "amsacrine",
"start": 22,
"end": 31
},
{
"text": "CI - 921",
"start": 41,
"end": 49
},
{
"text": "NSC 343499",
"start": 51,
"end": 61
},
{
"text": "CI -... | [] |
Alpha - lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy. The study investigates if alpha - lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, if mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and if neuroprotecti... | {
"entities": {
"chemical": [
{
"text": "Alpha - lipoic acid",
"start": 0,
"end": 19
},
{
"text": "alpha - lipoic acid",
"start": 135,
"end": 154
},
{
"text": "alpha - lipoic acid",
"start": 334,
"end": 353
... | [] |
Optimising stroke prevention in non - valvular atrial fibrillation. Atrial fibrillation is associated with substantial morbidity and mortality. Pooled data from trials comparing antithrombotic treatment with placebo have shown that warfarin reduces the risk of stroke by 62%, and that aspirin alone reduces the risk by 2... | {
"entities": {
"chemical": [
{
"text": "warfarin",
"start": 232,
"end": 240
},
{
"text": "aspirin",
"start": 285,
"end": 292
},
{
"text": "warfarin",
"start": 358,
"end": 366
},
{
"text": "as... | [] |
Interaction of cyclosporin A with antineoplastic agents. A synergistic effect of etoposide and cyclosporin A was observed in a patient with acute T - lymphocytic leukemia in relapse. The concomitant administration of etoposide and cyclosporin A resulted in eradication of hitherto refractory leukemic infiltration of bon... | {
"entities": {
"chemical": [
{
"text": "cyclosporin A",
"start": 15,
"end": 28
},
{
"text": "etoposide",
"start": 81,
"end": 90
},
{
"text": "cyclosporin A",
"start": 95,
"end": 108
},
{
"tex... | [] |
The hematologic effects of cefonicid and cefazedone in the dog: a potential model of cephalosporin hematotoxicity in man. Cephalosporin antibiotics cause a variety of hematologic disturbances in man, the pathogeneses and hematopathology of which remain poorly characterized. There is a need for a well - defined animal m... | {
"entities": {
"chemical": [
{
"text": "cefonicid",
"start": 27,
"end": 36
},
{
"text": "cefazedone",
"start": 41,
"end": 51
},
{
"text": "cephalosporin",
"start": 85,
"end": 98
},
{
"text": ... | [] |
A pyridoxine - dependent behavioral disorder unmasked by isoniazid. A 3 - year - old girl had behavioral deterioration, with hyperkinesis, irritability, and sleeping difficulties after the therapeutic administration of isoniazid. The administration of pharmacologic doses of pyridoxine hydrochloride led to a disappearan... | {
"entities": {
"chemical": [
{
"text": "pyridoxine",
"start": 2,
"end": 12
},
{
"text": "isoniazid",
"start": 57,
"end": 66
},
{
"text": "isoniazid",
"start": 219,
"end": 228
},
{
"text": "py... | [] |
A selective dopamine D4 receptor antagonist, NRA0160: a preclinical neuropharmacological profile. NRA0160, 5 - [2 - (4 - (3 - fluorobenzylidene) piperidin - 1 - yl) ethyl] - 4 - (4 - fluorophenyl) thiazole - 2 - carboxamide, has a high affinity for human cloned dopamine D4. 2, D4. 4 and D4. 7 receptors, with Ki values ... | {
"entities": {
"chemical": [
{
"text": "dopamine",
"start": 12,
"end": 20
},
{
"text": "NRA0160",
"start": 45,
"end": 52
},
{
"text": "NRA0160",
"start": 98,
"end": 105
},
{
"text": "5 - [2 -... | [] |
Prolonged cholestasis after troleandomycin - induced acute hepatitis. We report the case of a patient in whom troleandomycin - induced hepatitis was followed by prolonged anicteric cholestasis. Jaundice occurred after administration of troleandomycin for 7 days and was associated with hypereosinophilia. Jaundice disapp... | {
"entities": {
"chemical": [
{
"text": "troleandomycin",
"start": 28,
"end": 42
},
{
"text": "troleandomycin",
"start": 110,
"end": 124
},
{
"text": "troleandomycin",
"start": 236,
"end": 250
},
{
... | [] |
HMG CoA reductase inhibitors. Current clinical experience. Lovastatin and simvastatin are the 2 best - known members of the class of hypolipidaemic agents known as HMG CoA reductase inhibitors. Clinical experience with lovastatin includes over 5000 patients, 700 of whom have been treated for 2 years or more, and experi... | {
"entities": {
"chemical": [
{
"text": "Lovastatin",
"start": 59,
"end": 69
},
{
"text": "simvastatin",
"start": 74,
"end": 85
},
{
"text": "lovastatin",
"start": 219,
"end": 229
},
{
"text":... | [] |
Sulfasalazine - induced lupus erythematosus. Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43 - year - old man, who was receiving long - term sulfasalazine therapy for chronic ulcerative colitis. After cessation of the sulfasalazine... | {
"entities": {
"chemical": [
{
"text": "Sulfasalazine",
"start": 0,
"end": 13
},
{
"text": "sulfasalazine",
"start": 230,
"end": 243
},
{
"text": "sulfasalazine",
"start": 307,
"end": 320
},
{
... | [] |
Optimization of levodopa therapy. While there is no single correct starting dose for levodopa therapy, many individuals can be started on either the 25 / 100 or controlled - release formula, following the general rule not to attempt to titrate carbidopa - levodopa to the point of " normality, " which can lead to toxici... | {
"entities": {
"chemical": [
{
"text": "levodopa",
"start": 16,
"end": 24
},
{
"text": "levodopa",
"start": 85,
"end": 93
},
{
"text": "carbidopa",
"start": 244,
"end": 253
},
{
"text": "levo... | [] |
Alpha and beta coma in drug intoxication uncomplicated by cerebral hypoxia. Four patients who were rendered comatose or stuporous by drug intoxication, but who were not hypoxic, are described. Three patients received high doses of chlormethiazole for alcohol withdrawal symptoms, and one took a suicidal overdose of nitr... | {
"entities": {
"chemical": [
{
"text": "chlormethiazole",
"start": 231,
"end": 246
},
{
"text": "alcohol",
"start": 251,
"end": 258
},
{
"text": "nitrazepam",
"start": 316,
"end": 326
},
{
"t... | [] |
Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery. BACKGROUND AND OBJECTIVE: Despite advantages of induction and maintenance of anaesthesia with sevoflurane, postoperative nausea and vomiting occurs frequently. Fentanyl is a commonly used supplement that may contr... | {
"entities": {
"chemical": [
{
"text": "fentanyl",
"start": 9,
"end": 17
},
{
"text": "sevoflurane",
"start": 78,
"end": 89
},
{
"text": "sevoflurane",
"start": 201,
"end": 212
},
{
"text": "... | [] |
Renal Fanconi syndrome and myopathy after liver transplantation: drug - related mitochondrial cytopathy? Advances in the field of transplantation provide a better quality of life and allow more favorable conditions for growth and development in children. However, combinations of different therapeutic regimens require c... | {
"entities": {
"chemical": [
{
"text": "Tacrolimus",
"start": 469,
"end": 479
},
{
"text": "MMF",
"start": 481,
"end": 484
},
{
"text": "steroids",
"start": 490,
"end": 498
},
{
"text": "Lami... | [] |
Antipsychotic - like profile of thioperamide, a selective H3 - receptor antagonist in mice. Experimental and clinical evidence points to a role of central histaminergic system in the pathogenesis of schizophrenia. The present study was designed to study the effect of histamine H (3) - receptor ligands on neuroleptic - ... | {
"entities": {
"chemical": [
{
"text": "thioperamide",
"start": 32,
"end": 44
},
{
"text": "histamine",
"start": 268,
"end": 277
},
{
"text": "apomorphine",
"start": 339,
"end": 350
},
{
"tex... | [] |
Transient platypnea - orthodeoxia - like syndrome induced by propafenone overdose in a young woman with Ebstein' s anomaly. In this report we describe the case of a 37 - year - old white woman with Ebstein' s anomaly, who developed a rare syndrome called platypnea - orthodeoxia, characterized by massive right - to - le... | {
"entities": {
"chemical": [
{
"text": "propafenone",
"start": 61,
"end": 72
},
{
"text": "propafenone",
"start": 536,
"end": 547
}
],
"disease": [
{
"text": "platypnea - orthodeoxia - like syndrome",
"start": 1... | [] |
A Phase II trial of cisplatin plus WR - 2721 (amifostine) for metastatic breast carcinoma: an Eastern Cooperative Oncology Group Study (E8188). BACKGROUND: Cisplatin has minimal antitumor activity when used as second - or third - line treatment of metastatic breast carcinoma. Older reports suggest an objective response... | {
"entities": {
"chemical": [
{
"text": "cisplatin",
"start": 20,
"end": 29
},
{
"text": "WR - 2721",
"start": 35,
"end": 44
},
{
"text": "amifostine",
"start": 46,
"end": 56
},
{
"text": "Cis... | [] |
Warfarin - induced iliopsoas hemorrhage with subsequent femoral nerve palsy. We present the case of a 28 - year - old man on chronic warfarin therapy who sustained a minor muscle tear and developed increasing pain and a flexure contracture of the right hip. Surgical exploration revealed an iliopsoas hematoma and femora... | {
"entities": {
"chemical": [
{
"text": "Warfarin",
"start": 0,
"end": 8
},
{
"text": "warfarin",
"start": 133,
"end": 141
},
{
"text": "warfarin",
"start": 496,
"end": 504
}
],
"disease": [
{... | [] |
Myasthenia gravis caused by penicillamine and chloroquine therapy for rheumatoid arthritis. We have described a unique patient who had reversible and dose - related myasthenia gravis after penicillamine and chloroquine therapy for rheumatoid arthritis. Although acetylcholine receptor antibodies were not detectable, the... | {
"entities": {
"chemical": [
{
"text": "penicillamine",
"start": 28,
"end": 41
},
{
"text": "chloroquine",
"start": 46,
"end": 57
},
{
"text": "penicillamine",
"start": 189,
"end": 202
},
{
"... | [] |
Nephrotoxicity of combined cephalothin - gentamicin regimen. Two patients developed acute tubular necrosis, characterized clinically by acute oliguric renal failure, while they were receiving a combination of cephalothin sodium and gentamicin sulfate therapy. Patients who are given this drug regimen should be observed ... | {
"entities": {
"chemical": [
{
"text": "cephalothin",
"start": 27,
"end": 38
},
{
"text": "gentamicin",
"start": 41,
"end": 51
},
{
"text": "cephalothin sodium",
"start": 209,
"end": 227
},
{
... | [] |
Components of lemon essential oil attenuate dementia induced by scopolamine. The anti - dementia effects of s - limonene and s - perillyl alcohol were observed using the passive avoidance test (PA) and the open field habituation test (OFH). These lemon essential oils showed strong ability to improve memory impaired by ... | {
"entities": {
"chemical": [
{
"text": "scopolamine",
"start": 64,
"end": 75
},
{
"text": "s - limonene",
"start": 108,
"end": 120
},
{
"text": "s - perillyl alcohol",
"start": 125,
"end": 145
},
{
... | [] |
The selective 5 - HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Antagonists at serotonin type 6 (5 - HT (6)) receptors show activity in models of learning and memory. Although the underlying mechanism (s) are not well understood, th... | {
"entities": {
"chemical": [
{
"text": "Ro4368554",
"start": 42,
"end": 51
},
{
"text": "serotonin",
"start": 167,
"end": 176
},
{
"text": "5 - HT",
"start": 185,
"end": 191
},
{
"text": "ace... | [] |
Lone atrial fibrillation associated with creatine monohydrate supplementation. Atrial fibrillation in young patients without structural heart disease is rare. Therefore, when the arrhythmia is present in this population, reversible causes must be identified and resolved. Thyroid disorders, illicit drug or stimulant use... | {
"entities": {
"chemical": [
{
"text": "creatine",
"start": 41,
"end": 49
},
{
"text": "magnesium",
"start": 645,
"end": 654
},
{
"text": "potassium",
"start": 660,
"end": 669
},
{
"text": "a... | [] |
Comparison of developmental toxicity of selective and non - selective cyclooxygenase - 2 inhibitors in CRL: (WI) WUBR Wistar rats - - DFU and piroxicam study. BACKGROUND: Cyclooxygenase (COX) inhibitors are one of the most often ingested drugs during pregnancy. Unlike general toxicity data, their prenatal toxic effects... | {
"entities": {
"chemical": [
{
"text": "DFU",
"start": 134,
"end": 137
},
{
"text": "piroxicam",
"start": 142,
"end": 151
},
{
"text": "piroxicam",
"start": 451,
"end": 460
},
{
"text": "DFU"... | [] |
Protective efficacy of neuroactive steroids against cocaine kindled - seizures in mice. Neuroactive steroids demonstrate pharmacological actions that have relevance for a host of neurological and psychiatric disorders. They offer protection against seizures in a range of models and seem to inhibit certain stages of dru... | {
"entities": {
"chemical": [
{
"text": "steroids",
"start": 35,
"end": 43
},
{
"text": "cocaine",
"start": 52,
"end": 59
},
{
"text": "steroids",
"start": 100,
"end": 108
},
{
"text": "steroi... | [] |
Kidney function and morphology after short - term combination therapy with cyclosporine A, tacrolimus and sirolimus in the rat. BACKGROUND: Sirolimus (SRL) may supplement calcineurin inhibitors in clinical organ transplantation. These are nephrotoxic, but SRL seems to act differently displaying only minor nephrotoxic e... | {
"entities": {
"chemical": [
{
"text": "cyclosporine A",
"start": 75,
"end": 89
},
{
"text": "tacrolimus",
"start": 91,
"end": 101
},
{
"text": "sirolimus",
"start": 106,
"end": 115
},
{
"tex... | [] |
Effect of fucoidan treatment on collagenase - induced intracerebral hemorrhage in rats. Inflammatory cells are postulated to mediate some of the brain damage following ischemic stroke. Intracerebral hemorrhage is associated with more inflammation than ischemic stroke. We tested the sulfated polysaccharide fucoidan, whi... | {
"entities": {
"chemical": [
{
"text": "fucoidan",
"start": 10,
"end": 18
},
{
"text": "fucoidan",
"start": 307,
"end": 315
},
{
"text": "fucoidan",
"start": 550,
"end": 558
},
{
"text": "Fuc... | [] |
Paracetamol - associated coma, metabolic acidosis, renal and hepatic failure. A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented. The diagnostic difficulty at presentation is highlighted. Continuous arteriovenous haemofiltration proved a valuable means of ... | {
"entities": {
"chemical": [
{
"text": "Paracetamol",
"start": 0,
"end": 11
},
{
"text": "paracetamol",
"start": 158,
"end": 169
}
],
"disease": [
{
"text": "coma",
"start": 25,
"end": 29
},
... | [] |
Hepatic reactions associated with ketoconazole in the United Kingdom. Ketoconazole was introduced in the United Kingdom in 1981. By November 1984 the Committee on Safety of Medicines had received 82 reports of possible hepatotoxicity associated with the drug, including five deaths. An analysis of the 75 cases that had ... | {
"entities": {
"chemical": [
{
"text": "ketoconazole",
"start": 34,
"end": 46
},
{
"text": "Ketoconazole",
"start": 70,
"end": 82
},
{
"text": "ketoconazole",
"start": 1398,
"end": 1410
},
{
... | [] |
Combined effects of prolonged prostaglandin E1 - induced hypotension and haemodilution on human hepatic function. Combined effects of prolonged prostaglandin E1 (PGE1) - induced hypotension and haemodilution on hepatic function were studied in 30 patients undergoing hip surgery. The patients were randomly allocated to ... | {
"entities": {
"chemical": [
{
"text": "prostaglandin E1",
"start": 30,
"end": 46
},
{
"text": "prostaglandin E1",
"start": 144,
"end": 160
},
{
"text": "PGE1",
"start": 162,
"end": 166
},
{
... | [] |
Levodopa - induced dyskinesias in patients with Parkinson' s disease: filling the bench - to - bedside gap. Levodopa is the most effective drug for the treatment of Parkinson' s disease. However, the long - term use of this dopamine precursor is complicated by highly disabling fluctuations and dyskinesias. Although pre... | {
"entities": {
"chemical": [
{
"text": "Levodopa",
"start": 0,
"end": 8
},
{
"text": "Levodopa",
"start": 108,
"end": 116
},
{
"text": "dopamine",
"start": 224,
"end": 232
},
{
"text": "levod... | [] |
Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy. In this study, we investigated the therapeutic potential of bone marrow mononuclear cells (BMCs) in a model of epilepsy induced by pilocarpine in rats. BMCs obtained fr... | {
"entities": {
"chemical": [
{
"text": "pilocarpine",
"start": 283,
"end": 294
}
],
"disease": [
{
"text": "seizures",
"start": 14,
"end": 22
},
{
"text": "epilepsy",
"start": 142,
"end": 150
},
... | [] |
Cardioprotective effect of salvianolic acid A on isoproterenol - induced myocardial infarction in rats. The present study was designed to evaluate the cardioprotective potential of salvianolic acid A on isoproterenol - induced myocardial infarction in rats. Hemodynamic parameters and lead II electrocardiograph were mon... | {
"entities": {
"chemical": [
{
"text": "salvianolic acid A",
"start": 27,
"end": 45
},
{
"text": "isoproterenol",
"start": 49,
"end": 62
},
{
"text": "salvianolic acid A",
"start": 181,
"end": 199
},
... | [] |
Acute effects of N - (2 - propylpentanoyl) urea on hippocampal amino acid neurotransmitters in pilocarpine - induced seizure in rats. The present study aimed to investigate the anticonvulsant activity as well as the effects on the level of hippocampal amino acid neurotransmitters (glutamate, aspartate, glycine and GABA... | {
"entities": {
"chemical": [
{
"text": "N - (2 - propylpentanoyl) urea",
"start": 17,
"end": 47
},
{
"text": "amino acid",
"start": 63,
"end": 73
},
{
"text": "pilocarpine",
"start": 95,
"end": 106
},
... | [] |
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