input stringlengths 324 3.59k | output dict | schema listlengths 0 0 |
|---|---|---|
Acute hepatitis attack after exposure to telithromycin. INTRODUCTION: Antibiotic - associated hepatotoxicity is rare. With widespread use of antimicrobial agents, however, hepatic injury occurs frequently, and among adverse drug reactions, idiosyncratic reactions are the most serious. CASE SUMMARY: A 25 - year - old ma... | {
"entities": {
"chemical": [
{
"text": "telithromycin",
"start": 41,
"end": 54
},
{
"text": "telithromycin",
"start": 545,
"end": 558
},
{
"text": "alanine",
"start": 677,
"end": 684
},
{
"te... | [] |
Spironolactone - induced renal insufficiency and hyperkalemia in patients with heart failure. BACKGROUND: A previous randomized controlled trial evaluating the use of spironolactone in heart failure patients reported a low risk of hyperkalemia (2%) and renal insufficiency (0%). Because treatments for heart failure have... | {
"entities": {
"chemical": [
{
"text": "Spironolactone",
"start": 0,
"end": 14
},
{
"text": "spironolactone",
"start": 167,
"end": 181
},
{
"text": "spironolactone",
"start": 351,
"end": 365
},
{
... | [] |
End - stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin - based immunotherapy: risk of development and treatment. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramati... | {
"entities": {
"chemical": [
{
"text": "cyclosporine",
"start": 194,
"end": 206
},
{
"text": "tacrolimus",
"start": 211,
"end": 221
},
{
"text": "creatinine",
"start": 902,
"end": 912
},
{
"t... | [] |
Effect of intravenous nimodipine on blood pressure and outcome after acute stroke. BACKGROUND AND PURPOSE: The Intravenous Nimodipine West European Stroke Trial (INWEST) found a correlation between nimodipine - induced reduction in blood pressure (BP) and an unfavorable outcome in acute stroke. We sought to confirm thi... | {
"entities": {
"chemical": [
{
"text": "nimodipine",
"start": 22,
"end": 32
},
{
"text": "Nimodipine",
"start": 123,
"end": 133
},
{
"text": "nimodipine",
"start": 198,
"end": 208
},
{
"text"... | [] |
Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine. BACKGROUND: Recent evidence suggests that transient neurologic symptoms (TNSs) frequently follow lidocaine spinal anesthesia but are infrequent with bupivacaine. However, identification of a sho... | {
"entities": {
"chemical": [
{
"text": "prilocaine",
"start": 78,
"end": 88
},
{
"text": "bupivacaine",
"start": 93,
"end": 104
},
{
"text": "lidocaine",
"start": 115,
"end": 124
},
{
"text":... | [] |
The role of nicotine in smoking - related cardiovascular disease. Nicotine activates the sympathetic nervous system and in this way could contribute to cardiovascular disease. Animal studies and mechanistic studies indicate that nicotine could play a role in accelerating atherosclerosis, but evidence among humans is to... | {
"entities": {
"chemical": [
{
"text": "nicotine",
"start": 12,
"end": 20
},
{
"text": "Nicotine",
"start": 66,
"end": 74
},
{
"text": "nicotine",
"start": 229,
"end": 237
},
{
"text": "nicot... | [] |
Seizure resulting from a venlafaxine overdose. OBJECTIVE: To report a case of venlafaxine overdose. CASE SUMMARY: A 40 - year - old woman with major depression took an overdose of venlafaxine in an apparent suicide attempt. After the ingestion of 26 venlafaxine 50 - mg tablets, the patient experienced a witnessed gener... | {
"entities": {
"chemical": [
{
"text": "venlafaxine",
"start": 25,
"end": 36
},
{
"text": "venlafaxine",
"start": 78,
"end": 89
},
{
"text": "venlafaxine",
"start": 180,
"end": 191
},
{
"text... | [] |
Effect of nifedipine on renal function in liver transplant recipients receiving tacrolimus. The effect of nifedipine on renal function in liver transplant recipients who were receiving tacrolimus was evaluated between January 1992 and January 1996. Two groups of patients receiving tacrolimus were compared over a period... | {
"entities": {
"chemical": [
{
"text": "nifedipine",
"start": 10,
"end": 20
},
{
"text": "tacrolimus",
"start": 80,
"end": 90
},
{
"text": "nifedipine",
"start": 106,
"end": 116
},
{
"text": ... | [] |
Sinus arrest associated with continuous - infusion cimetidine. The administration of intermittent intravenous infusions of cimetidine is infrequently associated with the development of bradyarrhythmias. A 40 - year - old man with leukemia and no history of cardiac disease developed recurrent, brief episodes of apparent... | {
"entities": {
"chemical": [
{
"text": "cimetidine",
"start": 51,
"end": 61
},
{
"text": "cimetidine",
"start": 123,
"end": 133
},
{
"text": "cimetidine",
"start": 372,
"end": 382
},
{
"text"... | [] |
Composition of gall bladder stones associated with octreotide: response to oral ursodeoxycholic acid. Octreotide, an effective treatment for acromegaly, induces gall bladder stones in 13 - 60% of patients. Because knowledge of stone composition is essential for studies of their pathogenesis, treatment, and prevention, ... | {
"entities": {
"chemical": [
{
"text": "octreotide",
"start": 51,
"end": 61
},
{
"text": "ursodeoxycholic acid",
"start": 80,
"end": 100
},
{
"text": "Octreotide",
"start": 102,
"end": 112
},
{
... | [] |
Cardiovascular complications associated with terbutaline treatment for preterm labor. Severe cardiovascular complications occurred in eight of 160 patients treated with terbutaline for preterm labor. Associated corticosteroid therapy and twin gestations appear to be predisposing factors. Potential mechanisms of the pat... | {
"entities": {
"chemical": [
{
"text": "terbutaline",
"start": 45,
"end": 56
},
{
"text": "terbutaline",
"start": 169,
"end": 180
}
],
"disease": [
{
"text": "Cardiovascular complications",
"start": 0,
"... | [] |
Neurologic effects of subarachnoid administration of 2 - chloroprocaine - CE, bupivacaine, and low pH normal saline in dogs. The purpose of this study was to evaluate the neurologic consequences of deliberate subarachnoid injection of large volumes of 2 - chloroprocaine - CE in experimental animals. The possible role o... | {
"entities": {
"chemical": [
{
"text": "2 - chloroprocaine - CE",
"start": 53,
"end": 76
},
{
"text": "bupivacaine",
"start": 78,
"end": 89
},
{
"text": "2 - chloroprocaine - CE",
"start": 252,
"end": 275
... | [] |
Early adjuvant adriamycin in superficial bladder carcinoma. A multicenter study was performed in 110 patients with superficial transitional cell carcinoma of the bladder. Adriamycin (50 mg / 50 ml) was administered intravesically within 24 h after transurethral resection of TA - T1 (O - A) bladder tumors. Instillation ... | {
"entities": {
"chemical": [
{
"text": "adriamycin",
"start": 15,
"end": 25
},
{
"text": "Adriamycin",
"start": 171,
"end": 181
},
{
"text": "Adriamycin",
"start": 1440,
"end": 1450
}
],
"disease":... | [] |
Hyperkalemia associated with sulindac therapy. Hyperkalemia has recently been recognized as a complication of nonsteroidal antiinflammatory agents (NSAID) such as indomethacin. Several recent studies have stressed the renal sparing features of sulindac, owing to its lack of interference with renal prostacyclin synthesi... | {
"entities": {
"chemical": [
{
"text": "sulindac",
"start": 29,
"end": 37
},
{
"text": "indomethacin",
"start": 163,
"end": 175
},
{
"text": "sulindac",
"start": 244,
"end": 252
},
{
"text": ... | [] |
Ventricular tachyarrhythmias during cesarean section after ritodrine therapy: interaction with anesthetics. This case illustrates that patients receiving ritodrine for preterm labor may risk interactions between the residual betamimetic effects of ritodrine and the effects of anesthetics during cesarean section. Such i... | {
"entities": {
"chemical": [
{
"text": "ritodrine",
"start": 59,
"end": 68
},
{
"text": "ritodrine",
"start": 154,
"end": 163
},
{
"text": "ritodrine",
"start": 248,
"end": 257
},
{
"text": "... | [] |
Immunohistochemical, electron microscopic and morphometric studies of estrogen - induced rat prolactinomas after bromocriptine treatment. To clarify the effects of bromocriptine on prolactinoma cells in vivo, immunohistochemical, ultrastructural and morphometrical analyses were applied to estrogen - induced rat prolact... | {
"entities": {
"chemical": [
{
"text": "estrogen",
"start": 70,
"end": 78
},
{
"text": "bromocriptine",
"start": 113,
"end": 126
},
{
"text": "bromocriptine",
"start": 164,
"end": 177
},
{
"t... | [] |
On two paradoxical side - effects of prednisolone in rats, ribosomal RNA biosyntheses, and a mechanism of action. Liver enlargement and muscle wastage occurred in Wistar rats following the subcutaneous administration of prednisolone. In the liver both the content of RNA and the biosynthesis of ribosomal RNA increased w... | {
"entities": {
"chemical": [
{
"text": "prednisolone",
"start": 37,
"end": 49
},
{
"text": "prednisolone",
"start": 220,
"end": 232
},
{
"text": "prednisolone",
"start": 674,
"end": 686
}
],
"disea... | [] |
Possible intramuscular midazolam - associated cardiorespiratory arrest and death. Midazolam hydrochloride is commonly used for dental or endoscopic procedures. Although generally consisted safe when given intramuscularly, intravenous administration is known to cause respiratory and cardiovascular depression. This repor... | {
"entities": {
"chemical": [
{
"text": "midazolam",
"start": 23,
"end": 32
},
{
"text": "Midazolam hydrochloride",
"start": 82,
"end": 105
},
{
"text": "midazolam",
"start": 443,
"end": 452
},
{
... | [] |
Serial epilepsy caused by levodopa / carbidopa administration in two patients on hemodialysis. Two patients with similar clinical features are presented: both patients had chronic renal failure, on hemodialysis for many years but recently begun on a high - flux dialyzer; both had been receiving a carbidopa / levodopa p... | {
"entities": {
"chemical": [
{
"text": "levodopa / carbidopa",
"start": 26,
"end": 46
},
{
"text": "carbidopa / levodopa",
"start": 298,
"end": 318
},
{
"text": "vitamin B6",
"start": 556,
"end": 566
}
... | [] |
Effect of L - alpha - glyceryl - phosphorylcholine on amnesia caused by scopolamine. The present study was carried out to test the effects of L - alpha - glycerylphosphorylcholine (L - alpha - GFC) on memory impairment induced by scopolamine in man. Thirty - two healthy young volunteers were randomly allocated to four ... | {
"entities": {
"chemical": [
{
"text": "L - alpha - glyceryl - phosphorylcholine",
"start": 10,
"end": 50
},
{
"text": "scopolamine",
"start": 72,
"end": 83
},
{
"text": "L - alpha - glycerylphosphorylcholine",
"start":... | [] |
Seizures induced by the cocaine metabolite benzoylecgonine in rats. The half - life (t1 / 2) of cocaine is relatively short, but some of the consequences of its use, such as seizures and strokes, can occur hours after exposure. This led us to hypothesize that a metabolite of cocaine may be responsible for some of those... | {
"entities": {
"chemical": [
{
"text": "cocaine",
"start": 24,
"end": 31
},
{
"text": "benzoylecgonine",
"start": 43,
"end": 58
},
{
"text": "cocaine",
"start": 96,
"end": 103
},
{
"text": "c... | [] |
Protection against amphetamine - induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist. LY274614, 3SR, 4aRS, 6SR, 8aRS - 6 - [phosphonomethyl] decahydr oisoquinoline - 3 - carboxylic acid, has been described as a potent antagonist of the N - methyl - D - aspa... | {
"entities": {
"chemical": [
{
"text": "amphetamine",
"start": 19,
"end": 30
},
{
"text": "dopamine",
"start": 71,
"end": 79
},
{
"text": "LY274614",
"start": 102,
"end": 110
},
{
"text": "am... | [] |
Neonatal pyridoxine responsive convulsions due to isoniazid therapy. A 17 - day - old infant on isoniazid therapy 13 mg / kg daily from birth because of maternal tuberculosis was admitted after 4 days of clonic fits. No underlying infective or biochemical cause could be found. The fits ceased within 4 hours of administ... | {
"entities": {
"chemical": [
{
"text": "pyridoxine",
"start": 9,
"end": 19
},
{
"text": "isoniazid",
"start": 50,
"end": 59
},
{
"text": "isoniazid",
"start": 96,
"end": 105
},
{
"text": "pyr... | [] |
Reversal by phenylephrine of the beneficial effects of intravenous nitroglycerin in patients with acute myocardial infarction. Nitroglycerin has been shown to reduce ST - segment elevation during acute myocardial infarction, an effect potentiated in the dog by agents that reverse nitroglycerin - induced hypotension. Ou... | {
"entities": {
"chemical": [
{
"text": "phenylephrine",
"start": 12,
"end": 25
},
{
"text": "nitroglycerin",
"start": 67,
"end": 80
},
{
"text": "Nitroglycerin",
"start": 127,
"end": 140
},
{
... | [] |
Elevation of ADAM10, ADAM17, MMP - 2 and MMP - 9 expression with media degeneration features CaCl2 - induced thoracic aortic aneurysm in a rat model. PURPOSE: This study was designed to establish a rat model of thoracic aortic aneurysm (TAA) by calcium chloride (CaCl (2)) - induced arterial injury and to explore the po... | {
"entities": {
"chemical": [
{
"text": "CaCl2",
"start": 93,
"end": 98
},
{
"text": "calcium chloride",
"start": 245,
"end": 261
},
{
"text": "CaCl (2)",
"start": 263,
"end": 271
},
{
"text":... | [] |
When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration. Twenty - three hours after heart transplantation, life - threatening acute right heart failure was diagnosed in a patient requiring continuous venovenous hemodiafiltration (CVVHDF). Increasing doses of catecholamines, sed... | {
"entities": {
"chemical": [
{
"text": "catecholamines",
"start": 301,
"end": 315
},
{
"text": "epinephrine",
"start": 434,
"end": 445
},
{
"text": "catecholamine",
"start": 676,
"end": 689
}
],
"d... | [] |
Long - term glutamate supplementation failed to protect against peripheral neurotoxicity of paclitaxel. Toxic peripheral neuropathy is still a significant limiting factor for chemotherapy with paclitaxel (PAC), although glutamate and its closely related amino acid glutamine were claimed to ameliorate PAC neurotoxicity.... | {
"entities": {
"chemical": [
{
"text": "glutamate",
"start": 12,
"end": 21
},
{
"text": "paclitaxel",
"start": 92,
"end": 102
},
{
"text": "paclitaxel",
"start": 193,
"end": 203
},
{
"text": ... | [] |
Attentional modulation of perceived pain intensity in capsaicin - induced secondary hyperalgesia. Perceived pain intensity is modulated by attention. However, it is not known that how pain intensity ratings are affected by attention in capsaicin - induced secondary hyperalgesia. Here we show that perceived pain intensi... | {
"entities": {
"chemical": [
{
"text": "capsaicin",
"start": 54,
"end": 63
},
{
"text": "capsaicin",
"start": 236,
"end": 245
},
{
"text": "capsaicin",
"start": 575,
"end": 584
},
{
"text": "... | [] |
Testosterone - dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt - sensitive rats. Blood pressure (BP) is more salt sensitive in men than in premenopausal women. In Dahl salt - sensitive rats (DS), high - salt (HS) diet increases BP more in males than females. In contrast to the systemi... | {
"entities": {
"chemical": [
{
"text": "Testosterone",
"start": 0,
"end": 12
},
{
"text": "salt",
"start": 93,
"end": 97
},
{
"text": "salt",
"start": 144,
"end": 148
},
{
"text": "salt",
... | [] |
Prenatal protein deprivation alters dopamine - mediated behaviors and dopaminergic and glutamatergic receptor binding. Epidemiological evidence indicates that prenatal nutritional deprivation may increase the risk of schizophrenia. The goal of these studies was to use an animal model to examine the effects of prenatal ... | {
"entities": {
"chemical": [
{
"text": "dopamine",
"start": 36,
"end": 44
},
{
"text": "apomorphine",
"start": 511,
"end": 522
},
{
"text": "amphetamine",
"start": 562,
"end": 573
},
{
"text"... | [] |
mToR inhibitors - induced proteinuria: mechanisms, significance, and management. Massive urinary protein excretion has been observed after conversion from calcineurin inhibitors to mammalian target of rapamycin (mToR) inhibitors, especially sirolimus, in renal transplant recipients with chronic allograft nephropathy. B... | {
"entities": {
"chemical": [
{
"text": "rapamycin",
"start": 201,
"end": 210
},
{
"text": "sirolimus",
"start": 241,
"end": 250
},
{
"text": "sirolimus",
"start": 498,
"end": 507
},
{
"text":... | [] |
Hypothalamic prolactin receptor messenger ribonucleic acid levels, prolactin signaling, and hyperprolactinemic inhibition of pulsatile luteinizing hormone secretion are dependent on estradiol. Hyperprolactinemia can reduce fertility and libido. Although central prolactin actions are thought to contribute to this, the m... | {
"entities": {
"chemical": [
{
"text": "ribonucleic acid",
"start": 42,
"end": 58
},
{
"text": "estradiol",
"start": 182,
"end": 191
},
{
"text": "estrogen",
"start": 507,
"end": 515
},
{
"te... | [] |
Estrogen prevents cholesteryl ester accumulation in macrophages induced by the HIV protease inhibitor ritonavir. Individuals with HIV can now live long lives with drug therapy that often includes protease inhibitors such as ritonavir. Many patients, however, develop negative long - term side effects such as premature a... | {
"entities": {
"chemical": [
{
"text": "cholesteryl ester",
"start": 18,
"end": 35
},
{
"text": "ritonavir",
"start": 102,
"end": 111
},
{
"text": "ritonavir",
"start": 224,
"end": 233
},
{
"... | [] |
Upregulation of brain expression of P - glycoprotein in MRP2 - deficient TR (-) rats resembles seizure - induced up - regulation of this drug efflux transporter in normal rats. PURPOSE: The multidrug resistance protein 2 (MRP2) is a drug efflux transporter that is expressed predominantly at the apical domain of hepatoc... | {
"entities": {
"chemical": [
{
"text": "phenytoin",
"start": 879,
"end": 888
},
{
"text": "pilocarpine",
"start": 2017,
"end": 2028
},
{
"text": "phenobarbital",
"start": 2138,
"end": 2151
},
{
... | [] |
Use of chromosome substitution strains to identify seizure susceptibility loci in mice. Seizure susceptibility varies among inbred mouse strains. Chromosome substitution strains (CSS), in which a single chromosome from one inbred strain (donor) has been transferred onto a second strain (host) by repeated backcrossing, ... | {
"entities": {
"chemical": [
{
"text": "pilocarpine",
"start": 445,
"end": 456
},
{
"text": "pilocarpine",
"start": 734,
"end": 745
},
{
"text": "pilocarpine",
"start": 868,
"end": 879
}
],
"diseas... | [] |
Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine. Mitochondrial abnormalities have been associated with several aspects of epileptogenesis, such as energy generation, control of cell death, neurotransmitter synthesis, and free radical (FR) production. Increased pro... | {
"entities": {
"chemical": [
{
"text": "pilocarpine",
"start": 92,
"end": 103
},
{
"text": "pilocarpine",
"start": 743,
"end": 754
}
],
"disease": [
{
"text": "epilepsy",
"start": 72,
"end": 80
},
... | [] |
Causes of acute thrombotic microangiopathy in patients receiving kidney transplantation. OBJECTIVES: Thrombotic microangiopathy is a well - known problem in patients following renal transplantation. In postrenal transplantation, thrombotic microangiopathy is often a reflection of hemolytic uremic syndrome. We aimed to ... | {
"entities": {
"chemical": [
{
"text": "cyclosporine",
"start": 1104,
"end": 1116
},
{
"text": "cyclosporine",
"start": 1151,
"end": 1163
},
{
"text": "tacrolimus",
"start": 1168,
"end": 1178
},
{
... | [] |
Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose. Catecholamine - induced cardiomyopathy due to chronic excess of endogenous catecholamines has been recognized for decades as a clinical phenomenon. In contrast, reports of myocardial dysfunction due ... | {
"entities": {
"chemical": [
{
"text": "epinephrine",
"start": 99,
"end": 110
},
{
"text": "Catecholamine",
"start": 121,
"end": 134
},
{
"text": "catecholamines",
"start": 196,
"end": 210
},
{
... | [] |
Urinary bladder cancer in Wegener' s granulomatosis: risks and relation to cyclophosphamide. OBJECTIVE: To assess and characterise the risk of bladder cancer, and its relation to cyclophosphamide, in patients with Wegener' s granulomatosis. METHODS: In the population based, nationwide Swedish Inpatient Register a cohor... | {
"entities": {
"chemical": [
{
"text": "cyclophosphamide",
"start": 75,
"end": 91
},
{
"text": "cyclophosphamide",
"start": 179,
"end": 195
},
{
"text": "cyclophosphamide",
"start": 630,
"end": 646
},
... | [] |
L - arginine transport in humans with cortisol - induced hypertension. A deficient L - arginine - nitric oxide system is implicated in cortisol - induced hypertension. We investigate whether abnormalities in L - arginine uptake contribute to this deficiency. Eight healthy men were recruited. Hydrocortisone acetate (50 ... | {
"entities": {
"chemical": [
{
"text": "L - arginine",
"start": 0,
"end": 12
},
{
"text": "cortisol",
"start": 38,
"end": 46
},
{
"text": "L - arginine",
"start": 83,
"end": 95
},
{
"text": "... | [] |
MR imaging with quantitative diffusion mapping of tacrolimus - induced neurotoxicity in organ transplant patients. Our objective was to investigate brain MR imaging findings and the utility of diffusion - weighted (DW) imaging in organ transplant patients who developed neurologic symptoms during tacrolimus therapy. Bra... | {
"entities": {
"chemical": [
{
"text": "tacrolimus",
"start": 50,
"end": 60
},
{
"text": "tacrolimus",
"start": 297,
"end": 307
},
{
"text": "tacrolimus",
"start": 428,
"end": 438
},
{
"text"... | [] |
Octreotide - induced hypoxemia and pulmonary hypertension in premature neonates. The authors report 2 cases of premature neonates who had enterocutaneous fistula complicating necrotizing enterocolitis. Pulmonary hypertension developed after administration of a somatostatin analogue, octreotide, to enhance resolution of... | {
"entities": {
"chemical": [
{
"text": "Octreotide",
"start": 0,
"end": 10
},
{
"text": "octreotide",
"start": 284,
"end": 294
}
],
"disease": [
{
"text": "hypoxemia",
"start": 21,
"end": 30
},
... | [] |
Sequential observations of exencephaly and subsequent morphological changes by mouse exo utero development system: analysis of the mechanism of transformation from exencephaly to anencephaly. Anencephaly has been suggested to develop from exencephaly; however, there is little direct experimental evidence to support thi... | {
"entities": {
"chemical": [
{
"text": "5 - azacytidine",
"start": 569,
"end": 584
}
],
"disease": [
{
"text": "exencephaly",
"start": 27,
"end": 38
},
{
"text": "exencephaly",
"start": 164,
"end": 175
... | [] |
Acute cocaine - induced seizures: differential sensitivity of six inbred mouse strains. Mature male and female mice from six inbred stains were tested for susceptibility to behavioral seizures induced by a single injection of cocaine. Cocaine was injected ip over a range of doses (50 - 100 mg / kg) and behavior was mon... | {
"entities": {
"chemical": [
{
"text": "cocaine",
"start": 6,
"end": 13
},
{
"text": "cocaine",
"start": 226,
"end": 233
},
{
"text": "Cocaine",
"start": 235,
"end": 242
},
{
"text": "cocaine... | [] |
Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy. We describe 3 episodes of microangiopathic hemolytic anemia (MAHA) in 2 solid organ recipients under FK506 (tacrolimus) therapy. In both cases, discontinuation of FK506 and treatment with plasma exchange, fresh frozen plasma replacement, cortico... | {
"entities": {
"chemical": [
{
"text": "FK506",
"start": 47,
"end": 52
},
{
"text": "tacrolimus",
"start": 54,
"end": 64
},
{
"text": "FK506",
"start": 176,
"end": 181
},
{
"text": "tacrolimu... | [] |
Variant ventricular tachycardia in desipramine toxicity. We report a case of variant ventricular tachycardia induced by desipramine toxicity. Unusual features of the arrhythmia are repetitive group beating, progressive shortening of the R - R interval, progressive widening of the QRS complex with eventual failure of in... | {
"entities": {
"chemical": [
{
"text": "desipramine",
"start": 35,
"end": 46
},
{
"text": "desipramine",
"start": 120,
"end": 131
}
],
"disease": [
{
"text": "ventricular tachycardia",
"start": 8,
"end":... | [] |
Desipramine - induced delirium at " subtherapeutic " concentrations: a case report. An elderly patient treated with low dose Desipramine developed a delirium while her plasma level was in the " subtherapeutic " range. Delirium, which may be induced by tricyclic drug therapy in the elderly, can be caused by tricyclics w... | {
"entities": {
"chemical": [
{
"text": "Desipramine",
"start": 0,
"end": 11
},
{
"text": "Desipramine",
"start": 125,
"end": 136
},
{
"text": "antidepressants",
"start": 376,
"end": 391
}
],
"disea... | [] |
Mouse strain - dependent effect of amantadine on motility and brain biogenic amines. The effect of amantadine hydrochloride, injected i. p. in 6 increments of 100 mg / kg each over 30 hr, on mouse motility and whole brain content of selected biogenic amines and major metabolites was studied in 4 strains of mice. These ... | {
"entities": {
"chemical": [
{
"text": "amantadine",
"start": 35,
"end": 45
},
{
"text": "amines",
"start": 77,
"end": 83
},
{
"text": "amantadine hydrochloride",
"start": 99,
"end": 123
},
{
... | [] |
No enhancement by phenobarbital of the hepatocarcinogenicity of a choline - devoid diet in the rat. An experiment was performed to test whether inclusion of phenobarbital in a choline - devoid diet would increase the hepatocarcinogenicity of the diet. Groups of 5 - week old male Fischer - 344 rats were fed for 7 - 25 m... | {
"entities": {
"chemical": [
{
"text": "phenobarbital",
"start": 18,
"end": 31
},
{
"text": "choline",
"start": 66,
"end": 73
},
{
"text": "phenobarbital",
"start": 157,
"end": 170
},
{
"text... | [] |
Effect of direct intracoronary administration of methylergonovine in patients with and without variant angina. The effects of intracoronary administration of methylergonovine were studied in 21 patients with variant angina and 22 patients with atypical chest pain and in others without angina pectoris (control group). M... | {
"entities": {
"chemical": [
{
"text": "methylergonovine",
"start": 49,
"end": 65
},
{
"text": "methylergonovine",
"start": 158,
"end": 174
},
{
"text": "Methylergonovine",
"start": 319,
"end": 335
},
... | [] |
Dobutamine stress echocardiography: a sensitive indicator of diminished myocardial function in asymptomatic doxorubicin - treated long - term survivors of childhood cancer. Doxorubicin is an effective anticancer chemotherapeutic agent known to cause acute and chronic cardiomyopathy. To develop a more sensitive echocard... | {
"entities": {
"chemical": [
{
"text": "Dobutamine",
"start": 0,
"end": 10
},
{
"text": "doxorubicin",
"start": 108,
"end": 119
},
{
"text": "Doxorubicin",
"start": 173,
"end": 184
},
{
"text... | [] |
Effects of aminophylline on the threshold for initiating ventricular fibrillation during respiratory failure. Cardiac arrhythmias have frequently been reported in association with respiratory failure. The possible additive role of pharmacologic agents in precipitating cardiac disturbances in patients with respiratory f... | {
"entities": {
"chemical": [
{
"text": "aminophylline",
"start": 11,
"end": 24
},
{
"text": "aminophylline",
"start": 377,
"end": 390
},
{
"text": "aminophylline",
"start": 763,
"end": 776
},
{
... | [] |
Case report: acute unintentional carbachol intoxication. INTRODUCTION: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84 - year - old male discovered a newspaper report stating clinical succes... | {
"entities": {
"chemical": [
{
"text": "carbachol",
"start": 33,
"end": 42
},
{
"text": "carbachol",
"start": 90,
"end": 99
},
{
"text": "carbamylcholin",
"start": 447,
"end": 461
},
{
"text"... | [] |
Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine / caffeine in migraine. Rizatriptan is a selective 5 - HT (1B / 1D) receptor agonist with rapid oral absorption and early onset of action in the acute treatment of migraine. This randomized double - blind crossover outpatient study ... | {
"entities": {
"chemical": [
{
"text": "rizatriptan",
"start": 52,
"end": 63
},
{
"text": "ergotamine",
"start": 77,
"end": 87
},
{
"text": "caffeine",
"start": 90,
"end": 98
},
{
"text": "Ri... | [] |
Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a vinca alkal... | {
"entities": {
"chemical": [
{
"text": "cisplatin",
"start": 281,
"end": 290
},
{
"text": "bleomycin",
"start": 292,
"end": 301
},
{
"text": "vinca alkaloid",
"start": 309,
"end": 323
},
{
"t... | [] |
Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed / refractory paediatric T - cell lymphoblastic leukaemia and lymphoma. A combination of 5 d of nelarabine (AraG) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prophylactic intrathecal chemotherapy was used as salvage therapy in sev... | {
"entities": {
"chemical": [
{
"text": "nelarabine",
"start": 21,
"end": 31
},
{
"text": "etoposide",
"start": 33,
"end": 42
},
{
"text": "cyclophosphamide",
"start": 48,
"end": 64
},
{
"text... | [] |
The 3 - week sulphasalazine syndrome strikes again. A 34 - year - old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero - negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features o... | {
"entities": {
"chemical": [
{
"text": "sulphasalazine",
"start": 13,
"end": 27
},
{
"text": "sulphasalazine",
"start": 200,
"end": 214
},
{
"text": "sulphasalazine",
"start": 1164,
"end": 1178
},
{
... | [] |
Bupropion (Zyban) toxicity. Bupropion is a monocyclic antidepressant structurally related to amphetamine. Zyban, a sustained - release formulation of bupropion hydrochloride, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it' s introduction, 12 overdose cases have been repor... | {
"entities": {
"chemical": [
{
"text": "Bupropion",
"start": 0,
"end": 9
},
{
"text": "Zyban",
"start": 11,
"end": 16
},
{
"text": "Bupropion",
"start": 28,
"end": 37
},
{
"text": "antidepres... | [] |
Survey of complications of indocyanine green angiography in Japan. PURPOSE: We evaluated the safety of indocyanine green for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan, which were selected on the basis of the client list from the... | {
"entities": {
"chemical": [
{
"text": "indocyanine green",
"start": 27,
"end": 44
},
{
"text": "indocyanine green",
"start": 103,
"end": 120
},
{
"text": "indocyanine green",
"start": 213,
"end": 230
},
... | [] |
Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L - NOArg; 1. 0 mg / kg ip), a relatively selective inhibitor o... | {
"entities": {
"chemical": [
{
"text": "Bradykinin",
"start": 0,
"end": 10
},
{
"text": "nitric oxide",
"start": 37,
"end": 49
},
{
"text": "vincristine",
"start": 73,
"end": 84
},
{
"text": ... | [] |
Cardiac toxicity observed in association with high - dose cyclophosphamide - based chemotherapy for metastatic breast cancer. INTRODUCTION: Cyclophosphamide is an alkylating agent given frequently as a component of many conditioning regimens. In high doses, its nonhematological dose - limiting toxicity is cardiomyopath... | {
"entities": {
"chemical": [
{
"text": "cyclophosphamide",
"start": 58,
"end": 74
},
{
"text": "Cyclophosphamide",
"start": 140,
"end": 156
},
{
"text": "paclitaxel",
"start": 349,
"end": 359
},
{
... | [] |
Inappropriate use of carbamazepine and vigabatrin in typical absence seizures. Carbamazepine and vigabatrin are contraindicated in typical absence seizures. Of 18 consecutive referrals of children with resistant typical absences only, eight were erroneously treated with carbamazepine either as monotherapy or as an add ... | {
"entities": {
"chemical": [
{
"text": "carbamazepine",
"start": 21,
"end": 34
},
{
"text": "vigabatrin",
"start": 39,
"end": 49
},
{
"text": "Carbamazepine",
"start": 79,
"end": 92
},
{
"tex... | [] |
Hemolytic anemia associated with the use of omeprazole. Omeprazole is the first drug designed to block the final step in the acid secretory process within the parietal cell. It has been shown to be extremely effective in the treatment of peptic ulcer disease, reflux esophagitis, and the Zollinger - Ellison syndrome. Al... | {
"entities": {
"chemical": [
{
"text": "omeprazole",
"start": 44,
"end": 54
},
{
"text": "Omeprazole",
"start": 56,
"end": 66
},
{
"text": "omeprazole",
"start": 352,
"end": 362
},
{
"text": ... | [] |
The use and toxicity of didanosine (ddI) in HIV antibody - positive individuals intolerant to zidovudine (AZT) One hundred and fifty - one patients intolerant to zidovudine (AZT) received didanosine (ddI) to a maximum dose of 12. 5 mg / kg / day. Patient response was assessed using changes in CD4 + lymphocyte subset co... | {
"entities": {
"chemical": [
{
"text": "didanosine",
"start": 24,
"end": 34
},
{
"text": "ddI",
"start": 36,
"end": 39
},
{
"text": "zidovudine",
"start": 94,
"end": 104
},
{
"text": "AZT",
... | [] |
Can angiogenesis be a target of treatment for ribavirin associated hemolytic anemia? BACKGROUND / AIMS: Recently ribavirin has been found to inhibit angiogenesis and a number of angiogenesis inhibitors such as sunitinib and sorafenib have been found to cause acute hemolysis. We aimed to investigate whether there is a r... | {
"entities": {
"chemical": [
{
"text": "ribavirin",
"start": 46,
"end": 55
},
{
"text": "ribavirin",
"start": 113,
"end": 122
},
{
"text": "sunitinib",
"start": 210,
"end": 219
},
{
"text": "... | [] |
Cocaine causes memory and learning impairments in rats: involvement of nuclear factor kappa B and oxidative stress, and prevention by topiramate. Different mechanisms have been suggested for cocaine toxicity including an increase in oxidative stress but the association between oxidative status in the brain and cocaine ... | {
"entities": {
"chemical": [
{
"text": "Cocaine",
"start": 0,
"end": 7
},
{
"text": "topiramate",
"start": 134,
"end": 144
},
{
"text": "cocaine",
"start": 191,
"end": 198
},
{
"text": "cocai... | [] |
Antinociceptive and antiamnesic properties of the presynaptic cholinergic amplifier PG - 9. The antinociceptive effect of 3 alpha - tropyl 2 - (p - bromophenyl) propionate [(+ / -) - PG - 9] (10 - 40 mg kg - 1 s. c.; 30 - 60 mg kg - 1 p. o.; 10 - 30 mg kg - 1 i. v.; 10 - 30 micrograms / mouse i. c. v.) was examined in ... | {
"entities": {
"chemical": [
{
"text": "PG - 9",
"start": 84,
"end": 90
},
{
"text": "3 alpha - tropyl 2 - (p - bromophenyl) propionate",
"start": 122,
"end": 171
},
{
"text": "PG - 9",
"start": 183,
"end": 189
... | [] |
Hyperbaric oxygen therapy for control of intractable cyclophosphamide - induced hemorrhagic cystitis. We report a case of intractable hemorrhagic cystitis due to cyclophosphamide therapy for Wegener' s granulomatosis. Conservative treatment, including bladder irrigation with physiological saline and instillation of pro... | {
"entities": {
"chemical": [
{
"text": "oxygen",
"start": 11,
"end": 17
},
{
"text": "cyclophosphamide",
"start": 53,
"end": 69
},
{
"text": "cyclophosphamide",
"start": 162,
"end": 178
},
{
... | [] |
Further studies on effects of irrigation solutions on rat bladders. Further studies on the effects of certain irrigating fluids on the rat bladder for 18 hours are reported. The results have shown that the degradation product p - choloroaniline is not a significant factor in chlorhexidine - digluconate associated erosi... | {
"entities": {
"chemical": [
{
"text": "p - choloroaniline",
"start": 226,
"end": 244
},
{
"text": "chlorhexidine - digluconate",
"start": 276,
"end": 303
},
{
"text": "kanamycin",
"start": 354,
"end": 363
... | [] |
Clinical experiences in an open and a double - blind trial. A total of sixty patients were trated with bromperidol first in open conditions (20 patients), then on a double blind basis (40 patients) with haloperidol as the reference substance. The open study lasted for four weeks; the drug was administrated in the form ... | {
"entities": {
"chemical": [
{
"text": "bromperidol",
"start": 103,
"end": 114
},
{
"text": "haloperidol",
"start": 203,
"end": 214
},
{
"text": "haloperidol",
"start": 932,
"end": 943
},
{
"... | [] |
Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats. The antiepileptic drugs, phenobarbitone and carbamazepine are well known to cause cognitive impairment on chronic use. The increase in free radical generation has been implicated as one of the importan... | {
"entities": {
"chemical": [
{
"text": "Curcumin",
"start": 0,
"end": 8
},
{
"text": "phenobarbitone",
"start": 67,
"end": 81
},
{
"text": "carbamazepine",
"start": 86,
"end": 99
},
{
"text":... | [] |
Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model. Pyrrolidine dithiocarbamate (PDTC) has a dual mechanism of action as an antioxidant and an inhibitor of the transcription factor kappa - beta. Both, production of reactive oxygen species as well as activation of NF - k... | {
"entities": {
"chemical": [
{
"text": "Pyrrolidine dithiocarbamate",
"start": 0,
"end": 27
},
{
"text": "pilocarpine",
"start": 64,
"end": 75
},
{
"text": "Pyrrolidine dithiocarbamate",
"start": 102,
"end": 129... | [] |
Safety profile of a nicotine lozenge compared with that of nicotine gum in adult smokers with underlying medical conditions: a 12 - week, randomized, open - label study. BACKGROUND: Nicotine polacrilex lozenges deliver 25% to 27% more nicotine compared with equivalent doses of nicotine polacrilex gum. The increased nic... | {
"entities": {
"chemical": [
{
"text": "nicotine",
"start": 20,
"end": 28
},
{
"text": "nicotine",
"start": 59,
"end": 67
},
{
"text": "Nicotine",
"start": 182,
"end": 190
},
{
"text": "nicot... | [] |
Development of levodopa - induced dyskinesias in parkinsonian monkeys may depend upon rate of symptom onset and / or duration of symptoms. Levodopa - induced dyskinesias (LIDs) present a major problem for the long - term management of Parkinson' s disease (PD) patients. Due to the interdependence of risk factors in cli... | {
"entities": {
"chemical": [
{
"text": "levodopa",
"start": 15,
"end": 23
},
{
"text": "Levodopa",
"start": 139,
"end": 147
},
{
"text": "MPTP",
"start": 478,
"end": 482
},
{
"text": "levodop... | [] |
Propylthiouracil - induced perinuclear - staining antineutrophil cytoplasmic autoantibody - positive vasculitis in conjunction with pericarditis. OBJECTIVE: To describe a case of propylthiouracil - induced vasculitis manifesting with pericarditis. METHODS: We present the first case report of a woman with hyperthyroidis... | {
"entities": {
"chemical": [
{
"text": "Propylthiouracil",
"start": 0,
"end": 16
},
{
"text": "propylthiouracil",
"start": 179,
"end": 195
},
{
"text": "propylthiouracil",
"start": 335,
"end": 351
},
... | [] |
Two mouse lines selected for differential sensitivities to beta - carboline - induced seizures are also differentially sensitive to various pharmacological effects of other GABA (A) receptor ligands. Two mouse lines were selectively bred according to their sensitivity (BS line) or resistance (BR line) to seizures induc... | {
"entities": {
"chemical": [
{
"text": "beta - carboline",
"start": 59,
"end": 75
},
{
"text": "GABA",
"start": 173,
"end": 177
},
{
"text": "methyl beta - carboline - 3 - carboxylate",
"start": 354,
"end": 395
... | [] |
Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double - blind, crossover, double - dose study. Pain not responsive to morphine is often problematic. Animal and clinical studies have suggested that N - methyl - D - aspartate (NMDA) antagonists, such as ketamine... | {
"entities": {
"chemical": [
{
"text": "ketamine",
"start": 32,
"end": 40
},
{
"text": "morphine",
"start": 63,
"end": 71
},
{
"text": "morphine",
"start": 178,
"end": 186
},
{
"text": "N - m... | [] |
Endocrine screening in 1, 022 men with erectile dysfunction: clinical significance and cost - effective strategy. PURPOSE: We reviewed the results of serum testosterone and prolactin determination in 1, 022 patients referred because of erectile dysfunction and compared the data with history, results of physical examina... | {
"entities": {
"chemical": [
{
"text": "testosterone",
"start": 156,
"end": 168
},
{
"text": "Testosterone",
"start": 541,
"end": 553
},
{
"text": "testosterone",
"start": 636,
"end": 648
},
{
... | [] |
Thiopentone pretreatment for propofol injection pain in ambulatory patients. This study investigated propofol injection pain in patients undergoing ambulatory anaesthesia. In a randomized, double - blind trial, 90 women were allocated to receive one of three treatments prior to induction of anaesthesia with propofol. P... | {
"entities": {
"chemical": [
{
"text": "Thiopentone",
"start": 0,
"end": 11
},
{
"text": "propofol",
"start": 29,
"end": 37
},
{
"text": "propofol",
"start": 101,
"end": 109
},
{
"text": "pro... | [] |
Comparison of i. v. glycopyrrolate and atropine in the prevention of bradycardia and arrhythmias following repeated doses of suxamethonium in children. The effectiveness of administration of glycopyrrolate 5 and 10 micrograms kg - 1 and atropine 10 and 20 micrograms kg - 1 i. v. immediately before the induction of anae... | {
"entities": {
"chemical": [
{
"text": "glycopyrrolate",
"start": 20,
"end": 34
},
{
"text": "atropine",
"start": 39,
"end": 47
},
{
"text": "suxamethonium",
"start": 125,
"end": 138
},
{
"te... | [] |
Reduction in caffeine toxicity by acetaminophen. A patient who allegedly consumed 100 tablets of an over - the - counter analgesic containing sodium acetylsalicylate, caffeine, and acetaminophen displayed no significant CNS stimulation despite the presence of 175 micrograms of caffeine per mL of serum. Because salicyla... | {
"entities": {
"chemical": [
{
"text": "caffeine",
"start": 13,
"end": 21
},
{
"text": "acetaminophen",
"start": 34,
"end": 47
},
{
"text": "sodium acetylsalicylate",
"start": 142,
"end": 165
},
{
... | [] |
Flestolol: an ultra - short - acting beta - adrenergic blocking agent. Flestolol (ACC - 9089) is a nonselective, competitive, ultra - short - acting beta - adrenergic blocking agent, without any intrinsic sympathomimetic activity. Flestolol is metabolized by plasma esterases and has an elimination half - life of approx... | {
"entities": {
"chemical": [
{
"text": "Flestolol",
"start": 0,
"end": 9
},
{
"text": "Flestolol",
"start": 71,
"end": 80
},
{
"text": "ACC - 9089",
"start": 82,
"end": 92
},
{
"text": "Flest... | [] |
Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension. The effect of a 6 - week treatment with the calcium channel blocker nitrendipine or the angiotensin converting enzyme inhibitor enalapril on blood pressure, albuminuria, renal hemodynamics, and morpholo... | {
"entities": {
"chemical": [
{
"text": "calcium",
"start": 22,
"end": 29
},
{
"text": "nitrendipine",
"start": 46,
"end": 58
},
{
"text": "calcium",
"start": 162,
"end": 169
},
{
"text": "nit... | [] |
Treatment of tinnitus by intratympanic instillation of lignocaine (lidocaine) 2 per cent through ventilation tubes. Idiopathic subjective tinnitus (IST) is one of the most obscure otological pathologies. This paper presents the results of treating IST by intratympanic instillation of lignocaine (lidocaine) 2 per cent t... | {
"entities": {
"chemical": [
{
"text": "lignocaine",
"start": 55,
"end": 65
},
{
"text": "lidocaine",
"start": 67,
"end": 76
},
{
"text": "lignocaine",
"start": 285,
"end": 295
},
{
"text": "... | [] |
Perhexiline maleate and peripheral neuropathy. Peripheral neuropathy has been noted as a complication of therapy with perhexiline maleate, a drug widely used in France (and in clinical trials in the United States) for the prophylactic treatment of angina pectoris. In 24 patients with this complication, the marked slowi... | {
"entities": {
"chemical": [
{
"text": "Perhexiline maleate",
"start": 0,
"end": 19
},
{
"text": "perhexiline maleate",
"start": 118,
"end": 137
}
],
"disease": [
{
"text": "peripheral neuropathy",
"start": 24,
... | [] |
Effect of humoral modulators of morphine - induced increase in locomotor activity of mice. The effect of humoral modulators on the morphine - induced increase in locomotor activity of mice was studied. The subcutaneous administration of 10 mg / kg of morphine - HC1 produced a marked increase in locomotor activity in mi... | {
"entities": {
"chemical": [
{
"text": "morphine",
"start": 32,
"end": 40
},
{
"text": "morphine",
"start": 131,
"end": 139
},
{
"text": "morphine",
"start": 251,
"end": 259
},
{
"text": "mor... | [] |
Mechanisms of FK 506 - induced hypertension in the rat. - Tacrolimus (FK 506) is a powerful, widely used immunosuppressant. The clinical utility of FK 506 is complicated by substantial hypertension and nephrotoxicity. To clarify the mechanisms of FK 506 - induced hypertension, we studied the chronic effects of FK 506 o... | {
"entities": {
"chemical": [
{
"text": "FK 506",
"start": 14,
"end": 20
},
{
"text": "Tacrolimus",
"start": 58,
"end": 68
},
{
"text": "FK 506",
"start": 70,
"end": 76
},
{
"text": "FK 506",
... | [] |
Suxamethonium induced prolonged apnea in a patient receiving electroconvulsive therapy. Suxamethonium causes prolonged apnea in patients in whom pseudocholinesterase enzyme gets deactivated by organophosphorus (OP) poisons. Here, we present a similar incident in a severely depressed patient who received electroconvulsi... | {
"entities": {
"chemical": [
{
"text": "Suxamethonium",
"start": 0,
"end": 13
},
{
"text": "Suxamethonium",
"start": 88,
"end": 101
},
{
"text": "organophosphorus (OP) poisons",
"start": 193,
"end": 222
},... | [] |
The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: a double - blind placebo - controlled and randomized study. OBJECTIVE: To determine the safety and efficacy of adjunctive bupropion sustained - release (SR) on male sexual dysfunction (SD) induced by ... | {
"entities": {
"chemical": [
{
"text": "bupropion",
"start": 30,
"end": 39
},
{
"text": "selective serotonin reuptake inhibitor",
"start": 80,
"end": 118
},
{
"text": "bupropion",
"start": 242,
"end": 251
... | [] |
Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis - B surface antigen (HBSAG) seropositive cancer patients undergoing cytotoxic chemotherapy. Hepatitis B virus (HBV) is one of the major causes of chronic liver disease worldwide. Cancer patients who are chronic carriers of HBV have a higher he... | {
"entities": {
"chemical": [
{
"text": "Lamivudine",
"start": 0,
"end": 10
},
{
"text": "hepatitis - B surface antigen",
"start": 67,
"end": 96
},
{
"text": "HBSAG",
"start": 98,
"end": 103
},
{
... | [] |
Ginsenoside Rg1 restores the impairment of learning induced by chronic morphine administration in rats. Rg1, as a ginsenoside extracted from Panax ginseng, could ameliorate spatial learning impairment. Previous studies have demonstrated that Rg1 might be a useful agent for the prevention and treatment of the adverse ef... | {
"entities": {
"chemical": [
{
"text": "Ginsenoside Rg1",
"start": 0,
"end": 15
},
{
"text": "morphine",
"start": 71,
"end": 79
},
{
"text": "Rg1",
"start": 104,
"end": 107
},
{
"text": "gins... | [] |
A study on the effect of the duration of subcutaneous heparin injection on bruising and pain. AIM: This study was carried out to determine the effect of injection duration on bruising and pain following the administration of the subcutaneous injection of heparin. BACKGROUND: Although different methods to prevent bruisi... | {
"entities": {
"chemical": [
{
"text": "heparin",
"start": 54,
"end": 61
},
{
"text": "heparin",
"start": 255,
"end": 262
},
{
"text": "heparin",
"start": 372,
"end": 379
},
{
"text": "hepari... | [] |
Acute reserpine and subchronic haloperidol treatments change synaptosomal brain glutamate uptake and elicit orofacial dyskinesia in rats. Reserpine - and haloperidol - induced orofacial dyskinesia are putative animal models of tardive dyskinesia (TD) whose pathophysiology has been related to free radical generation and... | {
"entities": {
"chemical": [
{
"text": "reserpine",
"start": 6,
"end": 15
},
{
"text": "haloperidol",
"start": 31,
"end": 42
},
{
"text": "glutamate",
"start": 80,
"end": 89
},
{
"text": "Res... | [] |
Acute psychosis due to treatment with phenytoin in a nonepileptic patient. The development of psychosis related to antiepileptic drug treatment is usually attributed to the interaction between the epileptic brain substratum and the antiepileptic drugs. The case of a nonepileptic patient who developed psychosis followin... | {
"entities": {
"chemical": [
{
"text": "phenytoin",
"start": 38,
"end": 47
},
{
"text": "phenytoin",
"start": 322,
"end": 331
},
{
"text": "phenytoin",
"start": 449,
"end": 458
}
],
"disease": [
... | [] |
The effect of treatment with gum Arabic on gentamicin nephrotoxicity in rats: a preliminary study. In the present work we assessed the effect of treatment of rats with gum Arabic on acute renal failure induced by gentamicin (GM) nephrotoxicity. Rats were treated with the vehicle (2 mL / kg of distilled water and 5% w /... | {
"entities": {
"chemical": [
{
"text": "gum Arabic",
"start": 29,
"end": 39
},
{
"text": "gentamicin",
"start": 43,
"end": 53
},
{
"text": "gum Arabic",
"start": 168,
"end": 178
},
{
"text": ... | [] |
Visual hallucinations associated with zonisamide. Zonisamide is a broad - spectrum antiepileptic drug used to treat various types of seizures. Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered me... | {
"entities": {
"chemical": [
{
"text": "zonisamide",
"start": 38,
"end": 48
},
{
"text": "Zonisamide",
"start": 50,
"end": 60
},
{
"text": "zonisamide",
"start": 338,
"end": 348
},
{
"text": ... | [] |
GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury. Glomerular epithelial protein 1 (GLEPP1) is a podocyte receptor membrane protein tyrosine phosphatase located on the apical cell membrane of visceral glomerular epithelial cell and foot processes. This receptor plays a... | {
"entities": {
"chemical": [
{
"text": "tyrosine",
"start": 16,
"end": 24
},
{
"text": "PAN",
"start": 52,
"end": 55
},
{
"text": "tyrosine",
"start": 183,
"end": 191
},
{
"text": "Puromycin ... | [] |
Ticlopidine - induced aplastic anemia: report of three Chinese patients and review of the literature. In this study, three Chinese patients with ticlopidine - induced aplastic anemia were reported and another 13 patients in the English literature were reviewed. We attempted to find underlying similarities, evaluate the... | {
"entities": {
"chemical": [
{
"text": "Ticlopidine",
"start": 0,
"end": 11
},
{
"text": "ticlopidine",
"start": 145,
"end": 156
},
{
"text": "ticlopidine",
"start": 620,
"end": 631
},
{
"tex... | [] |
Facilitation of memory retrieval by pre - test morphine and its state dependency in the step - through type passive avoidance learning test in mice. Amnesia produced by scopolamine and cycloheximide were reversed by morphine given 30 min before the test trial (pre - test), and pre - test morphine also facilitated the m... | {
"entities": {
"chemical": [
{
"text": "morphine",
"start": 47,
"end": 55
},
{
"text": "scopolamine",
"start": 169,
"end": 180
},
{
"text": "cycloheximide",
"start": 185,
"end": 198
},
{
"tex... | [] |
Test conditions influence the response to a drug challenge in rodents. These studies were conducted to examine the differential response to a drug challenge under varied experimental test conditions routinely employed to study drug - induced behavioral and neurophysiological responses in rodents. Apomorphine, a nonsele... | {
"entities": {
"chemical": [
{
"text": "Apomorphine",
"start": 298,
"end": 309
},
{
"text": "dopamine agonist",
"start": 326,
"end": 342
},
{
"text": "dopamine",
"start": 467,
"end": 475
},
{
... | [] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.