Datasets:
mrlom
/
ec-active

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
O67108
5.6.2.2
ACT_SITE 121; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01384"
MENRENLVEIPIEEEVKQAYIDYAMSVIVGRAIPDVRDGLKPVQRRILYSMYEMGLLPDKPFKKSARIVGETLGKYHPHGDQAVYEALVRMAQDFTMRYPLIIGQGNFGSIDGDPAAQMRYTEAKLSPLAVEMLTDIDKDTVDFQPNFDDTLMEPEVLPSKFPNLLCNGTSGIAVGLATSIPPHNLTEVGNALVKLAQNPQISVDEIMEILKGPDFPTGGVIENFAQVKEIYKTGRGIIKVKGKAHVEKVQGGRERIVITEIPYQVNKAELIKKIADNVRNGKIKEISDIRDETDKEGIRIVVELKRDAKGEEVLKKLYKYTPLEKGFPVNLVVLIDKEPKLVDIKTLLREFIKHRLEVILRRSKYFLKKVQDRLHIVEGLLKAINFIDDIIERIRRSKDASEARNYLMEEFGLSEKQAQAVLDLRLQRLTSLEREKLLEEEKELREKIEYYKKLVASEGERIKVFIEETEELVKKYGDKRRTFIGGVKEVKEGSITVAVLQDGSIIPVEELPLEKAPVVNILRVPFTEGLFLVSNRGRVYWIAGSQALQGSKVSLKSREEKIVGAFIREKFGNRLLLATKKGYVKKIPLAEFEYKAQGMPIIKLTEGDEVVSIASSVDETHILLFTKKGRVARFSVREVPPSTPGARGVQGIKLEKNDETSGLRIWNGEPYLLVITAKGRVKKISHEEIPKTNRGVKGTEVSGTKDTLVDLIPIKEEVELLITTKNGKAFYDKINQKDIPLSTKKSIPRTRWKLEDDEIIKVVIKKSE
222
Q8P4F9
3.5.1.88
ACT_SITE 137; /evidence="ECO:0000255|HAMAP-Rule:MF_00163"
MALLPILEFPDPRLRTKAVPVDAAEVVSPAFQTLLDDMFQTMYEAPGIGLAASQVDVHKRFMVIDVSEEKDAPQVFINPEIVTRQGEQVYQEGCLSVPGIFADVSRADAITVRYLDRQGQPQELSTDGLLAVCIQHEMDHLDGKLFVDYLSPLKREMVRKKLAKLRKHVA
183
K3ZCU4
4.1.1.50
ACT_SITE 68; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 82; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 248; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 261; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MASSGFEGFEKRLELVFSLPSCGDGARAQHGLRLLPVGALREALDTVQCAVVSAAGNAAFDAYVLSESSLFVYPSRAILKTCGTTRLLRAVPILLRAAAGELGLALRSCRYSRGSYLFPEAQPFPHADFADEIRFLDGAVLSALRFRRSSVMPPSQRHSQQQHKWHVYAASTSDDDQHVDGATHFTVEVCMTELDRTLARQFYLTTTPGDGRRTSHAIGDAMTAASGLGDVNPRSLAFGYAFAPCGYSMNALDGARYATVHVTPEDGHSYASYECGGAEAGCALASVGKAIAVFRPATVSVSVCYDGAGTEAINTASIWSAVADAVEPMGLACRSRAAEAFPGATTVTYQTFTRTPASLDMINHS
196
Q55624
1.11.1.24
ACT_SITE 50; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P0A251"
MTEVLRVGQPAPDFTATAIVDQSFQTVKLSTYRGKYLVLFFYPLDFTFVCPTEIIAFSDRHSEFTALDTEVVGISVDSEFSHLAWIQTERKMGGIGNINYPLVSDLKKEISQAYNVLEPDAGIALRGLFIIDREGILQYATVNNLSFGRSVDETLRVLKAIRHVQSHPNEVCPVDWQEGDKTMIPDPEKAKTYFETVAEP
12
B3RZS0
1.2.1.12
ACT_SITE 151; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1"
MVKVGINGFGRIGRLVFRASIAKGGVDVVALNDPFLDAEYMAYLLRYDSTHGRFSGSIEVKNGNLVVNGSEIKVFAIRNPAEIPWGVSGADYVVESTGVFTTLDKAKAHLTGGAKKVVISAPSADAPMFVMGVNHTKYDAKSMDVVSNASCTTNCLAPLAKIIDDNFGIEEGLMTTIHAFTATQKTVDGPSGKKWRDGRGAGQNVIPASTGAAKAVGKVIPELNGKLTGMAFRVPVPDVSVVDLTCRLKKETTYEAIKEAVSKASKSSEFQGIMGYTEDDVVSSDFVGDTHSSIFDAKAGIMLSGTFVKLVSWYDNEFGYSNRVIDLIRHMDSQ
22
F1A1T9
3.1.3.1
ACT_SITE 109; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
MSHFLLEEDFTKKQRFTSVHKRIFYLLISLAIIATVVLLIAFLLPRGWEPPIKKTNIIMMVGDGMGPASLTMARISFSKDFTEEKSLFLDPYLVGTVRTYSHSNDVTDSAAAATAYASGIKTTNDVVGVDHLNKPAGTLFEAAKLKQMKTGVVVTTRISDATPACYFSHSVNRNYEYFIINQLLEKDLDVVLGGGKMYFGDNFDKIQSYNYTFVNTTEQMNNVASGKIMGLFADYNIPWEIDRLNDPILKKNVPSLSEMTKKALDLINQNNEHGFILMVEGSKIDVAAHINDAPTQIYETREFDNTFELVREWAEKDGNTIVIVTADHETGGLTLAYQEEIDGHPMYSWSPETLLQVTKSADEMARIITTNATKDVNVTQVIHQYTGITIKPEEEEKILSFLQYRDTDSNRFRAINQQIGRIVSNYAHVGFTTGGHSGVDVNLYTYGDKISPEKFEEREKKDELYTTDNYKDTMLMGNVNNIEIASFISQALGLDLPNITKSLINFDPNGKAYEDEMIHKYSK
141
A0A3B3I852
2.7.11.23
ACT_SITE 137; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1"
MSVDVKTRSKRYEKLDFLGEGQFATVYKARDKLTDTIVAIKKIKVGHRTEAKDGINRTALREIKLLQELHHSNIIGLLDAFGHKSNISLVFDFMETDLEVVIKDTSLVLTPANIKAYILMTLQGLEYMHQHWILHRDLKPNNLLLDGSGVLKLADFGLAKAFGSPNRVYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRIPFLAGDSDLDQLTKIFEALGTATDETWPGMSSLPDFVSFKIFPGTPLEHIFSAAGDDLLELLQGLFTFNPTTRTTATQALKMKYFSNRPGPTPGPQLPRPNCSAEALREKETVGLKRKIEGLETSKDRFMTSFYIYSLKFILNPLKTTLSQIYRYLCNKQRSPVHIFDIYLFCWCEQHVWV
103
O67547
6.2.1.5
ACT_SITE 249; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01988"
MAILVNKDTKVVVQGITGKEGSFHAKQCKEYGTQVVAGVTPGKGGMEVEGIPVFNTVKEAVKETGANCSLIFVPAPFAADAIVEALDAGIELVVCITEGIPVKDMMMVKDYMLKNYPNAKLVGPNCPGVITPGEAKVGIMPGHIFKRGKIGIVSRSGTLTYEAAYQLTKYGLGQSTAVGIGGDPVHGLTHRDVIEMFNKDPETEAILMIGEIGGTEEEEAAEYIEKEVDKPVFAYIAGITAPPGKRMGHAGAIIMGGKGTAKAKMEALEKAGAYVIENPAKIGETVAKILKVIELEEEERTSDAE
247
Q10309
7.6.2.1
ACT_SITE 408; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250|UniProtKB:Q9Y2Q0"
MDSRLNRIQSKMKLWIKDKNLSNPSIPLKVLNKSFRSSRQSSVSNGHGLYSLDRDETESLMSSHEASNAGISLDSSFRVIQVGQPEPQYGNNAVTNTKYDLFTFLPKCLYEQFRYFYNMYFLLVSLSQLIPPLKIGYLSTYIAPLIFVLLITLTKEAVDDLKRRRRDSYANNEIYTVNDSPCAAQNIQAGDVVYIAKDQRIPADMILLETTVGNEAFIRTDQLDGETDWKLRIPCSNQHTEGIVHADAPIKSVHHFYGTFTLNNQKRPISVDHTLWANTVLASDGVYGVVVYTGKDTRQSMNSSKAKTKVGLLEKEINFYSKILCTFVLVLSIGLTFSHGIKTDWYISVFRYLILFSSIIPINLRVNLDLAKIVHSKNTESDPNLPGVVVRSSNIPEELGRIEYVLTDKTGTLTQNEMEMKKLHVGTMGFSAESMDVVQACIQNYSTPIPLSEDSKTLVRNLVLALSLCHNVTPSKGHDGVVSYQAASPDEVAIVKWTSTLGLVLTNRTRDAITLNNNVYKILNIFPFKSETKRMGIIVQSPDEKITFYLKGADSIMQNFVKPSFWLEEECGNLAREGLRTLVVAKKDLSAEEYSAFSLAHSDASLSFSNSRDKKMEEIVSRYLENDMDLLGLTGVEDKLQKDVKITLELLRNAGIHVWMLTGDKVETARCIAISSRLVSRGQYIHTINQLSSREEAHNHLLTLRNKPDSCLIIDGESMEFCIGYLQNEFIDIVSDLSSVVICRCTPTQKANMTRLIQEKKQASVCCIGDGGNDVGMIQVANVGIGIVGKEGQQASLAADYSVKEFSHVSRLLLWHGRISYKQTSKLAMFVIHRGLLISVCQVVYSVISAFEPIALFQGLLLVGYSTMYTMLPVFSIVYDRDVSEKLVFLFPELYKEMREQKCFSYKNFISCVLISVYQGLIIQLFTFYLIGFEEEGKMLAVCFSCLIFNELIMVALQINTWEQTIVMSELLTLMMYILSVPFLTNYFELKFLLGLKFYWVSALILFISLLPVWCGKALKRKLKPSSYAKLQR
259
A0A3Q7F1C1
1.11.1.7
ACT_SITE 84; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MLLYKNSSIVSHQFCNTLRKMENLCLVFLLIVSIVFPVLGQGGLKTGFYSSSCPNAESIVKSTVQAEFDKDPTIAAGLLRLHFHDCFVRGCDGSVLISGSSAERNAVTNTGLRGFEVIDDAKSKLEASCLGVVSCADILALAARDAVDLVGGPSWGVPTGRRDGRNSSSSEAMNLPSPFDTVEVQRSKFAAKGLDDHDLVTLVGAHTIGQTDCRFVSYRLYNFTKTGNADPSIDQQFLTQLKTMCPKDGDGSKKVDLDKDSQLNFDVSFFKNIRNGNGILESDQRLFGDSSTKDVVDKYAGSIRGLLGLRFNYNFKQAMIKMSSIEVKTGTDGEIRKVCSRFNHYY
14
A9A450
1.1.1.37
ACT_SITE 173; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P61889"
MITIIGSGKVGGDAALFSALKRLDDQILLLDVAEGLPQGEAMDINHMLSEQGIDVEVKGSNNFEDMKGSNIVVVVAGSGRKPGMTRMDLLKINASIVKSVVENVKKYADDSMIIPVTNPLDPMAYITYKVSGFDRSRVFGMGGMLDLSRFRQFIHEATGHSRDSIRALVIGEHGENMLPLPRFSSVSGIPLPSLLPKEKLEELVQNTKQVAAKVIELKGATVHAPGNAISAIVEAVVRDRKQVIPVATYLDGEYDHSDVTIGVPAVIGKNGVEKIIELDLNDEEKQVFNKAVENVKGALSGVEI
5
A0A1U8JHJ2
3.1.1.11
ACT_SITE 435; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MDSMKSFQSYCKADELEEQAYRRRTRKRLIIIGLSTIVLIAIIIGAVFGTLFPVKSSKSNENPPTYTAESIKAICDVTRYPASCGSSIAAIRSSSNDTDPNPGPSKVFTLSMQVAAGELIRLSSLPQKIISSNVNIDPMVREELEICENLFEDAVEYINDSISAVQGGQGDEMVLSTAKINDIKTWLSSAITNQETCLDGLMEAANHAAIPQEMENATRNSTEFSSNSLAIATHIMTILQSFQVPIHRKLLKFDRHHHGLEFDPRFPLWVRRGDRRLLQEENPIPNITVAKDGSGDFRTISEAVELIPKKKKTRFVIYVKEGVYLENVSIDKDYWNVMIYGDGMYKTIVSGSLNKVDGTPTFSSGTLIAAGRRFIARDMGFINTAGPEKEQAVAMRSSSDQSVFYRCYFDAYQDTLYVHSNRQFFRDCHVTGTVDFIFGNAAVVLQNCSIQPRQPGPDQFNTITAQSKTDPNQNTGISIQRCHITPFDNLTATTYLGRPWKDFATTMFMQSHIGDIVDPAGWTQWTQGVDPPNTIFYAEYENLGPGSGINERINWPGVKPNVTTEEARRFTVESLIQGNQWLPKDSMVYESSLE
125
A0BYR7
2.7.11.1
ACT_SITE 159; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MQTGLVINQVKERILFFSPTVQGKMEREACTQDFEVIQGLGQGAFGKVFKVRHKKTKMVFALKQIAKKQIKQQKMTQQIINEVKIMYGLEHPNIVKLYNHYEEEDYIYLILECATGGQLWQKLNRVGRFDEKTVKQFMQEAMSAIEYLHTRNPPIIHRDIKPENILLDANGHIKIADFGWSNINNHQRTTYCGTLDYLAPEMILECGHDEKIDNWSLGVLIYELLTGKAPFAPSSQIKDQKESQKILEDNILKVKINFPNDFPSLAKSLVQGLLQRDPQKRFNIQKMREHPWFANCQIQQEVQSEQKVKAENIKDIIKDDKAQFSKEEIAKVVNRQINQPKEEDDVIIVVEDQKEKESTHDFSKNTVQLLNNKITDLQKQLNESKILLQVKIDEIKQLQQQQEQPSLQMNVDTRKLKLLEEEKTKWKQAYEQIRDELHEKQAENLKLNAELEKIQQLTKSLEKQKADKSLLQEKVKKLQEEIDQKDQQILELRTEQDGRVQNSFHGSFLNQSTIEDGKSVADLNLTFQEMKNSFQIAREQIEEFDKAQRRIIQQEAEIIALKSQLNEYKESIRIAIQEQYEDQMEELEKKQRDQIRELEAKHFNEITKYENDKMSLRDQCNELENLKSEISLLKKDQESANLIIMDLKKYKRLRYQMDSRLKEQDILILDLKEKERVYRKK
99
A0A2G3AK10
3.1.1.11
ACT_SITE 408; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MGGKIMISLISLILLVGVIVGIVVIVNKDGNSKDDKSIKVQMKKVHEFCQATEFQDACAKSLQGVAKNESATVQDYIIAAFQNTLDALKKGLNETGKTSVDKKSDPYNYMAVDDCKKLVQFAIEELDDSLNIVAETDTQSLHKYTYDLLNWLSGVYAYQSICIDAIEKPEYKSAIGNGLMNATQLTSNALHIVAEMSSLLKAFNIQIPEDHHDNDSSPHRRLLDFNKVDQDGYPTWFPAADRKLLGKSKEGKGKGGKGGDAGPPLPPVGSGPLTPNAVVAKDGSGKFKTVSDAVKAYPPNHQGRYIIYIKAGVYNEQVLVDKAQPNVFMYGDGAGKTIITCVNSAEFIAKGITFRNTAGPVGEQAVALRISGDKGAVFDCSIEGFQDTLYYQTYRQFYRNCVISGTLDFIFGRGTAVIQNSEIILRRPQRLNSQNTITADGKEQDVGITGVVVQNCKIVAEQSYFADRFKYENYLTRPWKKFSTNIFMENEIGDLIRPEGFMKWPDKDYENTCFIYEYANRGPGANTNRRSKIFKNYKVLSPQEATKYTVGTFLSANEWLPRTSAPFYLGLGGK
125
Q6ZRP7
1.8.3.2
ACT_SITE 91; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 94; /note="Nucleophile"; /evidence="ECO:0000250"
MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAAVGPGAGGAARLYRAGEDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHTEGSRPPACPRLDPIQPSDVLSLLDNRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTRALDGDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDVRKKSLPLPEKPHKEENSEIVVWREFDKSKLYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVLAKLFPGRPPVKKLLEMLQEWLASLPLDRIPYNAVLDLVNNKMRISGIFLTNHIKWVGCQGSRSELRGYPCSLWKLFHTLTVEASTHPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECGEHFEEMAKESMDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACHEEIKGLASWDEGHVLTFLKQHYGRDNLLDTYSADQGDSSEGGTLARGEEEEKRLTPPEVSHGDRDTQSVRPPGALGPRPALPESLHHSLDGKLQSLDGPGAHKEVGGAAPFLGVDFSSLDMSLCVVLYVASSLFLMVMYFFFRVRSRRWKVKHHHPAV
38
F6R3G8
3.1.1.3
ACT_SITE 144; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 168; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 255; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
RGICFKRLGCFRDDPPWGGIPQRRLKILPCSPEYINTRFLLYTNENPNRCQEIKATDPQSILASNFKTNRKTHFIIHGFIDKGEGNWLTDMCQKIIQAEQTNCICVDWRRGSRTFYSQAVNNIRVVGAKELRYSPSNVHIIGHSLGAHAAGEAGKRTTGEIGRITGLDPAEPCFQGAPEDVRLDPSDALFVDVIHTDSAPMIPCKGFGMSQTVGHLDFFPNGGKQMPGCKKNMLSTIMDINGIWEGTQAFVACNHLRSYKYYAESIINPEGFLGYPCDSYDDFEKNKCFPCPPEGCPQMGHFADRFKGNISEVGQTFYLNTGDAKNFARWRYRVSVTLNGTKDVKGCIKMAIYGESGNSRQHDIYGGSLKRGANFTKEIDVERNVGQVQKVKFLWFNNVIDFFRPQLGATTVTLQTADGEIQQFCSNCTVRKNVLQTLYPC
128
Q5AZ53
3.2.1.78
ACT_SITE 196; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q99036"; ACT_SITE 313; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q99036"
MIFSTLLSLALLATTATARKGFVTTKGDKFQLDGKDFYFAGSNAYYFPFNNNQTDVELGLSAAKKAGLLVFRTWGFNDKNVTYIEDGLPQYGGEGAGTTEVVFQWWQNGTSTIDLEPFDKVVNAAAKTGIKLIVTLVNNWADYGGMDVYTVNLGGQYHDDFYRLPQIKKAYKRYVKEMVTRYRNSPAIMAWELANEPRCGADGVRNLPASDECTPELLTSWIDEMSTYVKRLDPHHLVTWGGEGGFNYDSDDWAYNGSDGGDFEAELKLKNIDFGVFHSYPDWWSKTVEWTNKWIVDHARAARRVGKPVVHEEYGWLTPQGRLDNLGTVSNITRLEAVGGWQSISLREKMSDMFWQFGYSGYSYGRNHDDGFTIYLDDAEAQELVYKHAKEVNKLNRRR
172
F4NVM6
6.2.1.5
ACT_SITE 294; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03222, ECO:0000256|PIRSR:PIRSR001553-1"
MSSLIRQIPSVTSSGLMRASPAYAARRTLASTMTTSYNNTALNMMIDKNTKVICQGFTGKMGTLHSKAAIEYGTRMVGGTSPSKAGTTHLGLPVFGSVKEAVSEVKPDASVIYVPPPGAAAAIIEAIQAEIPLVVCITEGIPQQDMVKVKKILLNQNKSRLIGPNCPGIIKPDQCKIGIMPGHIHRPGKIGIVSRSGTLTYEAVAQTTAAGLGQTLCVGIGGDPFNGTNFVDCLKVFLADPETEGIVLIGEIGGSAEEDAAEYLMQHNMSRSNPKPVVSFIAGLSAPPGRRMGHAGAIISGGKGKAEDKVAALQRAGVIVSQSPAKLGYYMKKAFDDLKLGA
247
A0A803TKL3
2.3.2.26
ACT_SITE 940; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MATGMVEPVYGLSEEEEESRVLRVKVVAGIDLAKKDIFGASDPYVKLSLYASDESRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLNHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQEDDNDQREDSEHGWEVVDSNDSPAQRQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVASESDNNIRQINQEAAHRRFRSRRHISEDLDPEPLESGDVPEPWETISEENASSDSLSLSLPPPPASPVSRTTPQELSDELNRRLQITPDSNGEQLSSMIQRDPSARLRSCSVTDAVAEQSHLTLQTGPPRRVRSSTVTGGEESTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGATGSTSNSNNHLTEPQIRRPRSLSTPTVTLSAPLEGLLKESPVRRAVKDTLSNPQSPQPSPYNSPKPQHKLTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHLRPKPALNPNDLGPLPPGWEERIHLDGRTFYIDHRSQVLICGDIHTRDLVPNYDNKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVYHGKLLDGFFIRPFYKMMLGKPITLKDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEITVTNENKREYIDLVIQWRFVNRVQKQMNAFLELLMCGLGDVDVNDWRQHTIYKNGYCPNHPVIQWYWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYESFEELREKLLMAVENAQGFEGVD
65
F6PI53
3.5.4.5
ACT_SITE 60; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
MATKYTTPEALIALADGAKQRAYCPYSKFQVGAAVVVENGDVFTGCNVENACYPVGVCAERTAICKAVSEGHTKLVAVAVITNGKTVNFPCGLCRQSIREFGTDVTIYCAKKDRSYQTHKLKELLPLSFGAENLIQ
187
Q9KTP8
2.7.1.23
ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361"
MKKPFNVLAIIGKPRDQQAIQTHKEIYHWLRSLGYTVFIDDRLREILTDLPTEHFASLIELGKKADLAIVVGGDGNMLGAARVLSRFDISVIGVNRGNLGFLTDLNPEDFQQRLQEVLDGHYLQETRFLLEAEIHRHGQVKSHNAALNEAVLHPGKIAHMIEFEVYIDDNFAFSQRSDGLIVSTPTGSTAYSLSGGGPILSPSLNAITLVPMFPHTLSCRPLVVGGNQRIKLVVSPENRGTQEVSCDGQVSLPVSPGDEIHIYQSPNVLKLIHPQDYSYYHVLRTKLGWSSKLF
89
Q8LBZ4
3.4.19.12
ACT_SITE 176; /evidence="ECO:0000255"; ACT_SITE 179; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q96G74"; ACT_SITE 299; /evidence="ECO:0000250|UniProtKB:Q96G74"
MMICYSPITTCSRNAISIKRHLGSRLYGVVAHGSSKFSCYSLLSGLSRRHYTGFRVSVSNRPSSWHDKGLFGSVLINRPTVAPKEKLEVSFLSPEANMKCSKIESNMRNLYCYSRFAYTGVIVSLLVCYSSTSQSAYADSSRDKDANNVHHHSSDGKFHNGKRVYTDYSIIGIPGDGRCLFRSVAHGFCLRSGKLAPGEKMQRELADELRTRVADEFIQRRQETEWFVEGDFDTYVRQIRDPHVWGGEPELFMASHVLQMPITVYMKDDKAGGLISIAEYGQEYGKDDPIRVLYHGFGHYDALLLHESKASIPKSKL
175
P49615
2.7.11.1
ACT_SITE 126; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
99
A2QAN3
3.2.1.23
ACT_SITE 200; /note="Proton donor"; /evidence="ECO:0000305|PubMed:28391618"; ACT_SITE 298; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:28391618"
MKLSSACAIALLAAQAAGASIKHRINGFTLTEHSDPAKRELLQKYVTWDDKSLFINGERIMIFSGEFHPFRLPVKELQLDIFQKVKALGFNCVSFYVDWALVEGKPGEYRADGIFDLEPFFDAASEAGIYLLARPGPYINAESSGGGFPGWLQRVNGTLRSSDKAYLDATDNYVSHVAATIAKYQITNGGPIILYQPENEYTSGCCGVEFPDPVYMQYVEDQARNAGVVIPLINNDASASGNNAPGTGKGAVDIYGHDSYPLGFDCANPTVWPSGDLPTNFRTLHLEQSPTTPYAIVEFQGGSYDPWGGPGFAACSELLNNEFERVFYKNDFSFQIAIMNLYMIFGGTNWGNLGYPNGYTSYDYGSAVTESRNITREKYSELKLLGNFAKVSPGYLTASPGNLTTSGYADTTDLTVTPLLGNSTGSFFVVRHSDYSSEESTSYKLRLPTSAGSVTIPQLGGTLTLNGRDSKIHVTDYNVSGTNIIYSTAEVFTWKKFADGKVLVLYGGAGEHHELAISTKSNVTVIEGSESGISSKQTSSSVVVGWDVSTTRRIIQVGDLKILLLDRNSAYNYWVPQLATDGTSPGFSTPEKVASSIIVKAGYLVRTAYLKGSGLYLTADFNATTSVEVIGVPSTAKNLFINGDKTSHTVDKNGIWSATVDYNAPDISLPSLKDLDWKYVDTLPEIQSSYDDSLWPAADLKQTKNTLRSLTTPTSLYSSDYGFHTGYLLYRGHFTATGNESTFAIDTQGGSAFGSSVWLNGTYLGSWTGLYANSDYNATYNLPQLQAGKTYVITVVIDNMGLEENWTVGEDLMKTPRGILNFLLAGRPSSAISWKLTGNLGGEDYEDKVRGPLNEGGLYAERQGFHQPEPPSQNWKSSSPLEGLSEAGIGFYSASFDLDLPKGWDVPLFLNIGNSTTPSPYRVQVYVNGYQYAKYISNIGPQTSFPVPEGILNYRGTNWLAVTLWALDSAGGKLESLELSYTTPVLTALGEVESVDQPKYKKRKGAY
163
P24102
1.11.1.7
ACT_SITE 71; /note="Proton acceptor"
MGFSPSFSCSAIGALILGCLLLQASNSNAQLRPDFYFGTCPFVFDIIGNIIVDELQTDPRIAASLLRLHFHDCFVRGCDASILLDNSTSFRTEKDAAPNANSARGFNVIDRMKVALERACPGRVSCADILTIASQISVLLSGGPWWPVPLGRRDSVEAFFALANTALPSPFFNLTQLKTAFADVGLNRTSDLVALSGGHTFGRAQCQFVTPRLYNFNGTNSPDPSLNPTYLVELRRLCPQNGNGTVLVNFDVVTPDAFDSQYYTNLRNGKGLIQSDQELFSTPGADTIPLVNQYSSDMSVFFRAFIDAMIRMGNLRPLTGTQGEIRQNCRVVNPRIRVVENDDGVVSSI
14
A0A3Q1MNU5
3.1.1.4
ACT_SITE 67; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 112; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MGLSLLCALLVFAGVAPAEADILDLNEMVRQVTGKIPIFFYSSYGCYCRIGGQGQPRDATDWCCYDHNCCYGYLTPHNCDYLYDHYDYTFFQGNVQCSTKGSWCEQQLCACDKTLAFCLQRNLNTYKNHLRHLSRCEGETLACPPAS
130
F6I4G6
1.11.1.7
ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MPTLLFCIMFFLTVSVSSASLKVGFYKYTCPSAETIVRKVVNKAVSQNPGMAAGLIRMHFHDCFVRGCDGSVLLDSTPGNPSEKENPANNPSLRGFEVIDAAKAEIEAQCPQTVSCADVLAFAARDSAYKVGGINYAVPSGRRDGRVSLKDEPSLHLPPPFFNAKQLEDNFARKGLTLDEMVTLSGAHSIGVSHCSSFSNRLYSFNATHPQDPSMDPEFARHLKTKCPPPSNTGSDPTVPLEIQTPNKLDNKYYKDLKNTGAYWHQIRLFSTALQQRGW
14
Q74AI3
4.2.1.20
ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"
MSRIAGTFAELKHNSRKALVTFITAGDPDLAATEALIPLLAESGADIVELGVPFSDPMADGPTIQLSSERALAAGTTLPKILDMVRRVRTRCQVPIVLMGYYNPILIHGLERFAADASAAGVDGVLLVDLPPEEAAEFKACADRHGLDVIFLLTPTSDEGRIRKVARQARGFVYYVSVTGVTGARSGVEASVSSNVAAIREAITVPVVVGFGISTPDQAAQVAASADGVVVGSAIVKLFERFTAAELGREVATFVSALREAIGN
202
A0CZH4
2.7.11.1
ACT_SITE 214; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MNRFCDYKSCQYFIKQPTIEQRSKLNKVMCPLCMGANYCSTRCRDLDWPIYHKEICKKSQPDRARSCNDTIDSCSTTSVRRRPEEFEIITIGSKQELGRGSYGSVKLVKDKQNGLLYAMKIMNKRQVFEYCSVENLKREIKIQRKLAHPHICKLHHYFEDKENVYLILEYAQNGSLFNYIKKRSKLPENEAFVYFFQTCLGIDYLHKNKIIHRDLKPENLLLDHDGNVKICDFGWSAESLTEKRMTFCGTYEYMAPEMLNKQPHDFSLDVWSLGILLYELLHGNAPYRGRNNEELGNKIKSGQPINFAPTLSKEVITLIKGILKYIPGERLTMDQIFDNPWMVKHAANYNIDIWTFVYKTQYPTRQIPTVNFQQKQKPIEIQKKESLARPISQDYNKFKEQPINNNATNYKAYQNDYNNTKQDDVNKPRISRVSNRNEIMMHQHQLQQQQQEEKLTFMDRVFLAFGCLNREKK
99
Q5EAV9
3.4.19.12
ACT_SITE 15; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 116; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 131; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"
MSESVFHERQRLELCAVHALNNLLQKPEFSQQRAEEICRGLAPNSMINPHRSLLGTGNYDVNVIMAALQTMDYAAVWWDKRRSLESLVPSEIFGFILNIPSPVSLGFLSLPITRKHWIAVRQIDGVYYNLDSKLKAPIKLGGTKELKEFLHGCMSRGSCEILLVVGRDVEDARLWIRTEEQAAT
175
E9HZ30
1.11.1.6
ACT_SITE 10; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 83; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
MQPISLRILHSLLRGAFGYFEVTHDISKYCKAAVFGQVGKKTPVAVRFSTVGGESGSADTARDPRGFAVKFYTEEGNWDLVGNNTPIFFIRDPILFPSFIHTQKRNPVTHLKDPDMFWDFISLRPETTHQVCFLFSDRGTPDGYRFMNGYGSHTFKLVNAEGKPIYCKFHFKTDQGIRNLDAGKAHQLTADDPDYATRDLYNAISKADFPSWSVKIQVMTFEEAEKFKWNPFDLTKTWPQADFPLIPVGRMVLDRNPKDYFAEVEQIAFSPAHLVPGIEPSPDKMLQGRLFSYTDTHRHRLGTNYLHLPVNCPYRSKTLNYQRDGPMTFNTDYAGYPNYFPNSFSGPSDAPAALESKFEVSGDVARYNTADDDNFSQVGIYWTKVLDDGAKERLVQNIAGHLKSAQSFIQDRAVKNFTQAHADFGRRLRAALDKHISSSL
13
A0A8V0ZLR3
3.1.1.4
ACT_SITE 100; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 144; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MKLLVLLVCREYPLHGDGARLGLMAPLFSPFLEGSLSNANNSISPVAVLAPAGCNIAQFGIMIKEKTGKPALSYNGYGCHCGLGGSKYPVDATDWCCHAHDCCYKRLSSVTCVPHLATYKFSIKRGQITCGSGSSCQRAACECDKKAAECFKRNLRTFNKSYQNYLNFKCKGSRPSC
130
P32660
7.6.2.1
ACT_SITE 667; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250|UniProtKB:Q9Y2Q0"
MSGTFHGDGHAPMSPFEDTFQFEDNSSNEDTHIAPTHFDDGATSNKYSRPQVSFNDETPKNKREDAEEFTFNDDTEYDNHSFQPTPKLNNGSGTFDDVELDNDSGEPHTNYDGMKRFRMGTKRNKKGNPIMGRSKTLKWARKNIPNPFEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKRMQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDCKFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAGSAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRDLKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAALVATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQSGSNSEAILEKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTDVEIVREMWQHGHFDHYPPGYDPTDPNRPKVTKAGQHGEKIIEGIALSDNLGGSNYSRDSVVTEEIPMTFMHGEDGSPSGYQKQETWMTSPKETQDLLQSPQFQQAQTFGRGPSTNVRSSLDRTREQMIATNQLDNRYSVERARTSLDLPGVTNAASLIGTQQNN
259
O02658
3.1.3.16
ACT_SITE 123; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P36873"
MTAPMDVDNLMSRLLNVGMSGGRLTTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDVNFLFLGDYVDRGRQNIETICLMLCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKSMRRG
144
A0A804JWL8
3.1.3.48
ACT_SITE 26; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 28; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"
MVDRTPAVTFGEDQEISKPTTVYIWDMDETLILLKSLLDGTYAGVFNGMKDTKKGFEIGKHWENHILRVCDEFFFYEVIENYNEPYLDALSEYDDGRDLSNYDFSNDGFSSPYDDANKRKLAYRHRSIAEKYSQGLHKVLDQQMIKLWNDLYSLTDSYTGGWLSSAHALLEQTLAKTKPSASDHSSEMTPRSIITKDQSINVLVTSGSLVPSLAKCLLYRLDDVISANNVYSSWEVGKLQCFSWIKERFGSPNVRFCVIGDGTEECAAAETMRWPFIKIDIRPASPYRFPGLTMEMVQSYIDVIYGPQDSKDEKMKG
149
Q01389
2.7.11.1
ACT_SITE 1303; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MPFLRKIAGTAHTHSRSDSNSSVKFGHQPTSSVASTKSSSKSPRATSRKSIYDDIRSQFPNLTPNSTSSQFYESTPVIEQSFNWTTDDHISAGTLENPTSFTNSSYKNDNGPSSLSDSRKSSGGNSVNSLSFDKLILSWDPTDPDEWTMHRVTSWFKFHDFPESWILFFKKHQLFGHRFIKLLAYDNFAVYEKYLPQTKTASYTRFQQLLKKTMTKNVTNSHIRQKSASKLKSSRSSSESIKSKLKNSKSQEDISNSRSTSESALSPTKSGPSKTDEKNFLHSTSTHQKTKSASSLYRRSFISLRGSSSSNASSAKSPSNIKLSIPARPHSIIESNSTLTKSASPPASPSYPSIFRRHHKSSSSESSLLNSLFGSGIGEEAPTKPNPQGHSLSSENLAKGKSKHYETNVSSPLKQSSLPTSDDKGNLWNKFKRKSQIGVPSPNTVAYVTSQETPSLKSNSSTATLTVQTADVNIPSPSSSPPPIPKTANRSLEVISTEDTPKISSTTASFKETYPDCINPDKTVPVPVNNQKYSVKNFLLDQKFYPLKKTGLNDSENKYILVTKDNVSFVPLNLKSVAKLSSFKESALTKLGINHKNVTFHMTDFDCDIGAAIPDDTLEFLKKSLFLNTSGKIYIKDQMKLQQKPKPAPLTSENNVPLKSVKSKSSMRSGTSSLIASTDDVSIVTSSSDITSFDEHASGSGRRYPQTPSYYYDRVSNTNPTEELNYWNIKEVLSHEENAPKMVFKTSPKLELNLPDKGSKLNIPTPITENESKSSFQVLRKDEGTEIDFNHRRESPYTKPELAPKREAPKPPANTSPQRTLSTSKQNKPIRLVRASTKISRSKRSKPLPPQLLSSPIEASSSSPDSLTSSYTPASTHVLIPQPYKGANDVMRRLKTDQDSTSTSPSLKMKQKVNRSNSTVSTSNSIFYSPSPLLKRGNSKRVVSSTSAADIFEENDITFADAPPMFDSDDSDDDSSSSDDIIWSKKKTAPETNNENKKDEKSDNSSTHSDEIFYDSQTQDKMERKMTFRPSPEVVYQNLEKFFPRANLDKPITEGIASPTSPKSLDSLLSPKNVASSRTEPSTPSRPVPPDSSYEFIQDGLNGKNKPLNQAKTPKRTKTIRTIAHEASLARKNSVKLKRQNTKMWGTRMVEVTENHMVSINKAKNSKGEYKEFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVNETFNFKSTRLAKFIKSNDKLNSSKLRITSQENKTE
99
B8E0F4
6.3.4.2
ACT_SITE 381; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000256|HAMAP-Rule:MF_01227"; ACT_SITE 506; /evidence="ECO:0000256|HAMAP-Rule:MF_01227"; ACT_SITE 508; /evidence="ECO:0000256|HAMAP-Rule:MF_01227"
MSDTKFIFVTGGVISSLGKGLTTASLGRILKSKGFNVTALKFDPYINVDAGTMNPYQHGEVFVTEDGAETDLDLGHYERFLDVNLSAINNVTTGKIYSSVIRKEREGKYLGSTVQIIPHITEEIKNSIKLVAKETGADIVLVEIGGTVGDIEGLPFLEAARQFRKDVGKDNVIYLHVTLVPSLFPTGELKTKPTQHSVKELRSIGIQPDIILCRAKTKLPKSIREKIALFTDVEPEAVITGVDVEDLYAIPLYFEEEGLGDLVCKLLGLENRKSNLEDWKAMVNKELLGEVNITILGKYVTLPDAYISVVQALKHATRFYGVKLNIRWVESDKVNSENVDDVLKGTEGLLVPGGFGARGIEGMIEGIRWARKNKIPFLGLCLGLQCAVIEFARSIGLKYANSSEFDENTPDPVIDLMPNQKNINEKGGTMRLGAYPCVLDKSSLAYKYYQKEIIYERHRHRYEVNNKYRELFERHGLKIVGKSPDGELVEIIEIPDHPFFIATQFHPEYKSRPLNPHPLFKGFIENVIKEKEKKNG
252
A0A0K9PLU3
3.1.1.11
ACT_SITE 403; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAAASISSPFFQLVLVLLVIQAATMATAVTHQTMDVIKSTCKATPHPELCMNTLTNSSAVISIPTNPTLNFAAHTLDSAISKARKLSSFLADTGTGGTKELHDCKELHDISMSCLRRSASMCGINTGSLGKKELADINIYLSAALTNKITCLQGLSTVTGAKKDSLVNYLTDVYKYVSNSLAIVSKSKSSKSKLPSTVIHNRRLMGEMIPTWLPLRDRKVLQIGGINIGSGGNNEGYKGNDDNNGGTDIEAMLTLKVSADGSETYRTISDAVLDVPENSNSRTIIQIKAGVYEENVVIPSNKMNVAFVGEGADVTIIRGNRNVADGWKTFYSATVAVSGEGFLARDVTFENYAGPAKGQAVAIRINADLAALYHCNFVGYQNTLYVHSFRQFYRECNILGTVDFVFGNAAAIIQNSNIIARVPLHGQYNTITAQGRDDPNENTGISIQRCSILASQELAQNPDSAKTYLGRPWRIYSRTVYMDSLIEGLVDPAGWKNWDGDKGLDTLYYGEYANAGSGSNTDDRVNWAGYHIMGYEDTSQFTVPELIQGDQWLDSTHFPYDNYI
125
A0A0Q3FHP1
1.11.1.7
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MGRSSGVVVLVAVVAGMLLCVAEAQTQLKPGYYDQTCKDAEAIVFDEVRKAWNADRSVPAALLRLHFHDCFVNGCDGSVLLESWDRQAEKDAPPNKSLRGYEVIDRAKARLEMACRQTVSCADILAYAARDSVKVATGGFHYAVPGGRPDGTVSRATMANSNLPPPTQRNVDLLAQAFINKGLSKDDLIVLSGAHTLGVTRCGTFDYRLSNSNDKGMDPWFLNSLRAQCNRDASRVVPLDDGSQFAFDTKYYANVIANRGVLESDAALNSPSTVARVRQLRDGTPQTFHGAFAAAMGRMGALRGANPGKVRDHCRRVRT
14
A0A0D1E894
2.7.11.1
ACT_SITE 329; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MESQLANLHLDGGSTADLKQGSRPSHAQASHGNRHVHPTNSSLRPLAPSSSIASNMGINMGVNMQHFNRLAASSTGLTNPNSIAQGMSRAAQQPLNGSRPSTQQQPTQAHIKSRPPSVAGGLNAAAGPSYRPAAPAAQSTKQPASAGSAVASVDLGRYDGGLERDEARGRRGTMQFDPLTLSSADAGKQHPPTRVWSLKDFEMGRPLGKGKFGRVYMVRTRAAPNKGYIIALKCMYKNELVENKVEKQLRREIEIQMNLRHPHILRLHGYFHDEGRVFLMIEFAGRGELYKLMNKLHDRRFEEKVAATYIAQMADALSYLHSKHVIHRDIKPENLLLGIKGDLKIGDFGWSVHAPGNRRQTLCGTLDYLPPEMVNGEQHDKAVDLWALGVLCYEFLEGVPPFEELENAPAGTYKRINNIDFKIPRHFSPEAADLVKALLKKKPDDRLPLTKVLRHPWIMKYDPDACRRASRGKIQ
99
Q8IKK7
1.2.1.12
ACT_SITE 153; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1"
MAVTKLGINGFGRIGRLVFRAAFGRKDIEVVAINDPFMDLNHLCYLLKYDSVHGQFPCEVTHADGFLLIGEKKVSVFAEKDPSQIPWGKCQVDVVCESTGVFLTKELASSHLKGGAKKVIMSAPPKDDTPIYVMGINHHQYDTKQLIVSNASCTTNCLAPLAKVINDRFGIVEGLMTTVHASTANQLVVDGPSKGGKDWRAGRCALSNIIPASTGAAKAVGKVLPELNGKLTGVAFRVPIGTVSVVDLVCRLQKPAKYEEVALEIKKAAEGPLKGILGYTEDEVVSQDFVHDNRSSIFDMKAGLALNDNFFKLVSWYDNEWGYSNRVLDLAVHITNN
22
A0A0K9P7C1
2.1.1.33
ACT_SITE 159; /evidence="ECO:0000256|HAMAP-Rule:MF_03055"
MTRNGKQMEMNKNSSHHPRKRFYRARAHSNPLSDSHFPIPISPSEVDYSHHYPYFYPDGWNSNVNSNDGTASKIQFADIGCGFGGLLVSLSQLFPDTLMIGMELRDKVSEYVKERILALRMSIPGQYENISVVRTNSMKYLPNYFTKKQLTKMFFLFPDPHFKEKNHRRRVISPHLLDEYAYTLQTGGIIYTITDVEELGDWMRSCLEEHPLFQAVPEHELEADPVVKLLSGATEEGQKVARNEGQTFQAIYRRIELED
45
A0A067E8G7
3.1.1.11
ACT_SITE 169; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
IVFASITATCGFSATIPKDISTAVLIRVEKYGRGDFRTIQEAIDSVPANNSELVFISVAPGIYKEKIIVPANKPFITISGTKASHTKITWSDGGSILDSATLTVLASHFVARSLTIQNTYGSFGKAVALRVSADKAAFYGCRILSYQHTLLDDTGNHYYSKCYIEGATDFISGNANSFFERCLIHSLSTWGGAITAQKRVSSEENTGFTFLDCKISGVGKAVLGRPWGAYSRVVYALTYMSDVIVPQGWNDLNDHAKHNKLYYGEYRCSGPGADRSKRIAWSNSLSDVEASTFLSKDLTGRGTWLRNAALKFKDDFTINDANIKGNR
125
H2L099
2.7.11.1
ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MTTTSSDELPRQADDDSMKWDRIYIQKLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILVDLIERAAEYRLRTGVSSDSDLDEDSDGGGGTSKWDYPTVRGPRVSADDDGTVRQRTDRPRAQVDRRSPSGSPGGTIVRGSPQVAAVAEQLRNSSVGSSGYGSGGNSASSQYATSSLPQSHTASSGGATTITLGSPNGSPTSSLARTQSMVSPSGQRSGSAQSWELERGNRPMSERVSSQVSPSKYNQHRTSSSNGVQGGSGGRREYINGSGSGLNGNSSNQNHSEYSDAVRQRGPGGSGGRLDYRESHVPTSSQENLNHGRMYGYGAPPPSREANNVPMPRVKGALDCSLLPAIEHLSRTRHATAALDQLRHVFRDVEDSCPGICNELIEELMQRIAVPQVSQSDLDAAIRRLTTPPS
99
Q9Z7T0
1.2.1.12
ACT_SITE 151; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00362"
MKVVINGFGRIGRLVLRQILKRNSSVEVLAINDLVPGDALTYLFKFDSTHGRFPEDVRCEADHLIVGKRKIQFLSERNVQNLPWKDLGVDLVIECTGLFTKKEDAEKHIQAGAKRVLISAPGKGDIPTFVMGVNHKTFNPEKDFVISNASCTTNCLAPIAKVLLDNFGITEGLMTTVHAATATQLVVDGPSKKDWRGGRGCLQNIIPASTGAAKAVTLCLPELKGKLTGMAFRVPIEDVSVVDLTVRLDKSTTYDDICKAMKQASETDLKGILDYTDEQVVSSDFIGSEYSSIFDALAGIALNDRFFKLVAWYDNETGYATRIVDLLEYVEKNSK
22
B7QJK7
2.3.1.286
ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
MSCDYASGLSDYADKGVCGQPEQFDDAALLDDKIARLADWMQSSKHVVVITGAGISTSAGIPDFRGPNGVWTLEQKGEKPTLNISFDDAVPTPTHMALVALAERAKLQFLVSQNVDGLHLKSGFPLDTLADLHGNMFVDRCNQCRRQFIRDTATRTVGQKPTGEPCPVPKRNGRLCRGRLHDSILDWEDELPEDAIEAADAHCRVADLVLCLGSTLQIVPCGTLPLLAKKSAGKIIVCNLQPTKLDKSANLILRAYVDDVMTKLMAKLGIDIPSYSPGRDPTKGKRELPPVYPRLRLPKVAKALGSGRRPKQRTKKPQKRASVKDDAKDNLKKLIKAEEPTETSLVLVKESVENDPLLADVTG
58
Q54U31
2.7.11.1
ACT_SITE 400; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MKRFFSNLFKRKQDQNSHIKQINGPTTSTPTTTPTTPTTPTTTQTPTPQNNNTNNNTNNNNNTNSNNSNQQKKEQAQASPSTNQTQTPSNNTISTSPTVTTQPSFTPGVISTSKLTTSPPESPRPPTSTTNTTQPSTTTTTATNSTNTNTASAPTKTASPSSPSATASPNNNSNNTTTTAATTTTTTTTTTTTNANQTASVNHTSSDQSLNAQNVTQTNNNNNNNNNNNNNNNANNTKPINPNDYIPLDFVDSTPKVDNNQPKRKASGPPEILPEEIDRTDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTSFRHEVKIMSKIFHPNVVLFLGACTQSGKMQIVTELCQTDLEKLLHNDRTKKEFSLFRRMQMAKDAALGMNWLHGITRIVHNDLKTANLLVDINLRVKVTDFGFSQIKEGEEFQDKAAKGTPLWMAPEVMMGNPYNEKADVYSFGIILWEILTKEAPYSHHKDYDIFFNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEILFRLNEILIDCAIDFDDGRKYWKEHFLVPKQELQEEVEWSDFEKTLKATHKQLNLDYAPLKELLVQQSHQTVQKTKQVVTMERFDKVSKWFGSFFEPNTGIETIDNINKLSAKIWFHGDIVREQATSRLSKAAEGAFLIRLSSTEPKTCPFTLSMKNNQHRRIQLIDENNFTGFKIQGKTAVYNSLIELVEKCNDYPLLVPCPKFTQETFNPYDPYTN
99
K7KJK8
3.1.1.11
ACT_SITE 249; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MEQSVNAQIHITWLGSKCRSKQEKAAWSDCVTLYQDTINILNQALNPTKQSTSYDLQTWLTTSLTNTDTCQTGFHKVGVGNNVLPLIPNKNISKIISDFLTLNNASSFIPPKTNKNGFPRWLSPNDRKLLEDFKTIKEALKAVPKLSPKRFVIYVKHSVYNENIEYYVVCRSVGGGSTTFNSTNVDGFIARGITFRNTEGPENHQAGALRCGADLSVFHRCAFEGYQDTLYVHSQRQFYKECHIFGTVDFIFGNAAVVFQSCNIYATRSMQKQKNAIAAEDPNQNTGICIQNSRVMAVEDLVPVLSSFKTFLGRPWREYSRTVFLQTYLDALVDLAGVQERSSWGSTRDRVKWGGYHAITSATEASKFTVENFIAGKSWLPATGIPFLLGLDD
125
A0A9R1VGP5
3.1.1.11
ACT_SITE 408; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MNSHLFAGMPDFGNNKKFFFRVFASILLFSAVNGIVVGVNSQSPNINIESSTAHVIVKSSCSATLHPDLCYSTLSGIPEITEKITTPKDVIELAVNKTKEIVQRNYFTIKKLTVKTDLTKRQKIALHDCLEMVAETLQELNQVLAILSAYPMKKGSRRHVDGLMTLMSTTLTNQETCIDGFSHDKHDRKLRESLIAGEIHAEKLCSISLAMIKNMTDTDMANQVEINGRKLKEEEDDEWPEWLSIGDRKLLQLGTVTPNVTVAANGSGNFTTISAAVAAAPASSATRYVIRIAAGVYRENVNIPSNKRNLMFLGSGRTSTIITGSRSVAGGSTTFNSATVAAVGAGFLARDITFQNTAGPSGNQAVALRVGSDLSAFYLCDMIAYQDTLYVHSNRQFYINCFIAGTVDFIFGNAAAVFQNCDIHARRPNPNQRNMVTAQGRSDPNQNTGIVIQKSRIGATSDLLPVQGSFPTYLGRPWREYSRTVVMQSTISNVINPAGWFPWNGDFALNTLYYGEYQNTGAGAATANRVTWRGYRVIRDATEAGGFTAGNFIDGGSWLRATGFPFSLGL
125
A0A8I3N744
2.7.11.25
ACT_SITE 279; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1"
MAWPGAEGAADRPVSPGRGGPVGSASSSSASSGGSASASASASASASASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASLPPPPPPPPPRPGSPVHVDFARLQLQELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAAAASPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLERIEHDDFCNKTLKITDFGLAREWHRTTKMSAAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGTVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEALLRRREQQLAEREIDVLERELNILIFQLNQEKPNVKKRKGKFRRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSNGSSPPSSPTVIPRLRAIQLTSDESNKTWGRNTVCRQEEFEDVKKNFKKKGCTWGPNSIQMKERSDSKERMRPLSDGNSPWSTLIIKNQKTMPLASLFVDQPGASEESKLSPDGSEYRKPKQIKSPAQAYVDLPLWKDGQRENPVEPGSCEEGPSLSPAASTPQVTPTSNLSRSPQRKKTESALYGCSMLLASVALGLDIRELNKTQAAEELLPKEEKKRREGIFQWAPKARGSAIPCTRPPSTGERASSLPPLPLSSTMSLLSMSSLSTKCLLQTDGEDLSEGSTHITPDPETPTPDFCAAIRGCSGEPASMPRLETDHSRWKSPSPPFLEQIYGNVPYYASSKEQASHHRRTLSDGNAFQTPAGATPSTASADWDLPPEPAPGAPHSSAGPQAHLPGKAPPRKPRAGSTVPGPHLAALGSRTESRPALRGPGPTGAKDRPAAHLPSLLDAGAAGQSRDSAVPLRAVRSRTSPPPIQQLEKEFLS
105
Q9Y9L0
1.11.1.24
ACT_SITE 50; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00401, ECO:0000269|PubMed:16214169, ECO:0000269|PubMed:18436649"
MPGSIPLIGERFPEMEVTTDHGVIKLPDHYVSQGKWFVLFSHPADFTPVCTTEFVSFARRYEDFQRLGVDLIGLSVDSVFSHIKWKEWIERHIGVRIPFPIIADPQGTVARRLGLLHAESATHTVRGVFIVDARGVIRTMLYYPMELGRLVDEILRIVKALKLGDSLKRAVPADWPNNEIIGEGLIVPPPTTEDQARARMESGQYRCLDWWFCWDTPASRDDVEEARRYLRRAAEKPAKLLYEEARTHLH
12
A0A251TF74
1.8.1.4
ACT_SITE 477; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
MAMANLFRRKATRDVLRYSLYRGFASESEVNDVVVIGGGPGGYVAAIKAAQLGLKTTCIEKRGALGGTCLNVGCIPSKALLHSSHLYHEAKTKFANHGVKCSDVQVDLPAMMAQKDKAVFNLTKGVEALFKKNKVNYVKGAATFLSPSQISVEEEEEQGEKKTVVGKNIIIATGSDVKGLPGITIDEKRIVSSTGALALTQIPNKLIVIGAGYIGLEMGSVWARLGSEVTVVEFAPVIVPTMDGEIRRQFQRSLEKQKMKFMLNTKVMGVDTSSSDVVKLTLEPSAGGGDQTVLEADVVLVSAGRTPYTAGLGLENIGVETDKIGRIPVDRKFSTNVKGVYAIGDVIPGPMLAHRAEDDGIAVAEFIAGKEGHVDYDKVPGVVYTHPEVASVGKTEEQVKESGVAYRVGKFPMMGNSRAKSIDDAEGLVKVIAEKETDKILGVHIMASNAGELIHEAALAISYDASSEDIARTCHAHPTLSEALKEAAMATYDKPINI
36
A0A1B6QFX5
3.1.1.11
ACT_SITE 220; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MQQASACFSSTTSSSLLVMPVVALVMVVPLLLGLLSTTPSLAWAAPVSRTITVDCHGRGDVRTVQSAVDSVPDGNRDWIKIHVMAGSYWEKVSIPKQKGYILLEGDGSSTTDISFDAHAHAGIDDIMGRPNLTVDEQSPTFQSATFTVLADNFVARGIAFKNTYRAPDDQLSKENQAVAALVGGDKSAFYGCEFQGFQDTLCDYQGRHYFRGCQVRGAVDFVFGFGQSIYEDCALVSDMPPGPQPGWVTAHARGAAGSPGGLVFKGGAVQAAGGGGQTYLGRAWNAFAAVVFYRTRMDGVVVPQGWQAWNAAGNVSSVTFAEVECTGPGSEMGRRVDWEKRLSEDEVQRFVDIKFIDDGWLSNQP
125
A0A1L8FJD6
2.7.7.7
ACT_SITE 315; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50"
MEPRGIVKAFPKVKRLRENATLEDGGKKIKTAVDIHGTVFDGVLAHILQAGIGLARSEIFQKQIIQNGGQVTSQFSSEVTHIIVDEQMDCDRAFRLLKLEKISHHVQLVKSTWLSICINEKQMVNTAGYRIFIPDRYLDLKDRAEKEQSCESKGNYRKQHDELPHVPDKLNEAGNPQTQHVSDFPLLNYSNTSKTQNSDDEASDTEDTGVTQGDLDALISGQRPVLTSVKSHEVTNNVTGKWVCAHSSESKKTNYNQFITDKLEVLAKAYSVQGDRWRALGYSKAINALKSYHKPVTSCEEAASIPGIGKKMAEKIEEILDSGHLRKLDHISDSVAVLEIFSNIWGAGVKTAQSWYQQGFRTLDDIRTKGNLTAQQAIGLKHYDDFLDRMPRDEAGKIAQTVREMAHSLNPELISVACGSYRRGKATCGDVDVLVTHPDGKSHKGIFSKLIGGLKTQGFLTDDLVNQEVNGNQKKYLGVCRLPGEGQRHRRLDIIVVPYGEFACALMYFTGSAHFNRSMRALAKTKRMSLSEHSLNKDVVRNGSVKVSQGCPLPTPTEREVFETLGLPFREPHERDW
121
A0A9R0K247
2.1.1.37
ACT_SITE 427; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MADTMAEENVSMKRSFAECPVPCPKKKRVVSKDDIDECRFTGNPVPVQQAKEQWPHRYLCKAKEANAASFKIEWNCEEILQASNHYTQALVDGIIIKLHDDVYIQGDEGKPNYIAKIVEFFEGIDKKQYLTAQWFYRADDSVIKDHANFIDKKQVFFSDVKDDNELGCIVEKVKIDINPSDVGADKPNEYLYCKMRYRLPYLTFENMVQDEQNEGTGSDTSSTISSDHSSNEAVDDDSSTAKKEFSLLDLYSGCGAMSTGLCLGATLSGIKLVNRWAVDLNEYACESIRNNHPETKVRNEMAGDFLALLMEWEKLCNEYVLSPAPPSEVTNSEEEEEEEDDSPLEPGEFEVENILDICFGDPNYMKKRGLYFKVSWKGYTSEYDTWEPIDGLSGSEERIKEFVSRGYNEKLLPLPGDADFICGGPPCQGISGFNRFRNTVNPLNDEKNQQLVVYMDIINFLKPKYVLMENVVDLLRFAGGFLGRYAVGRLIGMNYQTRMGIMAAGSYGLPQYRMRVFLWGAHTSQKLPQFPLPTHEVIARGGVPVEFSDIHVSHGKNSSVKLERALLLKDAISDLPSVTNGEDREEMDYEGDSQSEFQQYIRLPRAQMVSFNDTHVVSSFPTNNILYDHNPLRLNDDDFERVCRIPKEKGANFRNLPGVLVDAKNKVYLDPSMERVLISSGKPLVPDYAITFVRGTSSKPFGRLWWDETVATVVTRAEPHNQIVLHPQQDRVLTIRENARLQGFLDCYKLYGPVKERYIQVGNAVAVPVATALGYAFGMASQRLGDEQPLMTLPFKFPHCLALNQH
47
Q5WA72
5.3.4.1
ACT_SITE 97; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 436; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 439; /note="Nucleophile"; /evidence="ECO:0000250"
MRARRVVAAAAVLLLFAVVAVARLDLDDDGDDSEVLDELLAVDEEEERGELGGGGEAAAAEAVRRAQSMVLVLDNDNARRAVEENAEVLLLGYAPWCERSAQLMPRFAEAAAALRAMGSAVAFAKLDGERYPKAASAVGVKGFPTVLLFVNGTEHQFTGLHTKDAIVTWVRKKTGAPASRIQSKDSAEEFLKKDQTFAVGLFKNFEGAEYEEFVKAATSENEVQFVETNDRNVAKILFPGIASEEQFLGLVKSEPEKFEKFNGAFEEKEIIQFVELNKFPLITVFTDLNSGKVYGSPIKLQVFTFAEAYDFEDLESMIQEVARGFKTKIMLIYVDTAEEKLAKPFLTLYGLEPEKPTVTAFDTSKGTKYLMEAEINAKNLQDFCLSLLEGTLPPYFRSEPVPEEKGPIEKVVGRTFDSSVLESPQNVFLEVHAPWCVDCEAISKNVEKLAKHFNDLGQTNLKFARIDASVNEHPKLQINNYPTLLLYPAQDKSNPIKLSKKSNLKDMAKFVKEKLQIADVETVAAGDIVKDEL
215
A0A2R6WYS8
1.11.1.7
ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAQFRSLLLAAILMFSGVVVDAYGPRDNGYVGLKDDYYGSSCKDAETVIKKAVQTELAKNLKHAAGVLRMHFHDCFVEGCDASVLLDGPATEKTAPVNAKLAGFEVIDAAKAAVEEICPGVVSCADILAYAARDSTVELNGTAWAVQGGRKDGTVSLASRAEAELPPPEFQVSQLIDSFARRGLSAKQMVVLSGSHTVGVSFCDKFVSRLYNFNSTFFTDPSIDPAYATELKNICPQHTFNTTIEVFMDVITPTSAGVFEANYYKTLQEHKGLFTSDQSLFDDTRTKAMVTSLLNNRRFQKEFGKAMRAMGRVGVKTKGQIRTNCRVVNTY
14
A0A8I3SCF8
3.4.19.9
ACT_SITE 134; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
MASLGRLLCVLGLLLWAAAGPGSCSPRASSSSKPIIGVLMQKCRNKELKSLGKYYIAASYVKYLESAGARVVPIRPDLTNEEYKKLFQSINGILFPGGSVDLKKSGYALAAKTFYNFAKQSFDDGDYFPVWGTCLGFEELSYLISGQCLLTLTHTDGITMPLNFTKDASQSRMFQNFPPDLLKSLSVEPLTANFHKWSLSVTNFTKNENLKEFFNVLTTNTDGKTEFISTMEGYKYPVYGVQWHPEKAPYEWGQLKGISHAPNAVKAAFYLAEFFVAEARKNSHHFESAVEENEALIYQFRPVYTGNISSFQQSYIFD
176
Q58643
6.2.1.5
ACT_SITE 251; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01988"
MVLRDKMILLDENTKAIVQGITGRQGSFHTKKMLECGTKIVGGVTPGKGGQNVHGVPVFDTVKEAVKETDANASVIFVPAPFAKDAVFEAIDAGIELIVVITEHIPVHDTMEFVNYAEDVGVKIIGPNTPGIASPKVGKLGIIPMEVLKEGSVGMVSRSGTLTYEIAHQIKKAGFGVSTCVGIGGDPIVGLRYKEVLDLFEKDDETEAIVMIGEIGGGAEEEAAKFIEKMKKPVIGYIAGQSAPEGKRMGHAGAIVEKGKGTAESKMKALEEAGAYVAKNISDIPKLLAGILGK
247
P9WN49
2.6.1.16
ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 619; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"
MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVRRRAGRLANLEEAVAEMPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNGIIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRLEGHFTLVFANADDPGTLVAARRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQAGRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVARVIAATGPVAELAHRFAQSSTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSATLHAKLLSNIREIQTRGAVTIVIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPLQVFAASVARARGYDVDKPRNLAKSVTVE
81
Q3TIW9
3.1.4.12
ACT_SITE 72; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q6UWV6"
MGHSAVLLCVALAILPACVTGAPVQRQHKLLLVSFDGFRWNYDQDVDTPNLDSMAQEGVKAQYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTSTVRLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEGVLHNYKNETEWRGNVDTVMKWFLEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLSDSLNLIITSDHGMTTVNKKASDLVEFHKFSNFTFQDIQFELLDYGPIGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKNFHYANNPRITPLLMYSDLGYVIHGRVNVQFNNGEHGFNNQDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCQLLGIVPEPNDGNPGILRPMLRSGSASLLSSQHHLVALLVGILTCLAKVL
154
Q0V0C5
2.7.1.11
ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184"
MAPTQVPPPLEGKKRRIGVMTSGGDAPGMNGAVRAVVRMAIHNNCEAYAIYEGYDGLVKGGDMIKEMTWDDVRGFLSEGGTLIGTARCMEFMQRDGRRTAAKNMIIKGIDALIICGGDGSLTGADKFRAEWPELLKELVEKKELTAEQIDPFKHLNIVGLVGSIDNDLSMTDATIGCYTSLGRICEAIDSVDTTAVSHQRAFVIEVMGRHCGWLALSSGVATGADFVFTPENPPDEGWQADMCRQIKKHRDMGKRKTIVVVAEGAIDRQLNKITSQQVKDILSNEAHLDTRITTLGHVQRGGTPCAYDRMLSTLQGSEAVKAVLEATPDTPSPVICMQENKIVRRPLLEAVAQTKEVAVAIENKDFHRAMQLRDTEFEEQYRSYQITTAADQPELLLPENKRMRVGIIHVGAPAGGMNAATRAAVAYCIARGHTPVALHNGFPGIIRHHSDKPLGAVREIKWIDAETWASKGGSEIGTNRGLPSEDLETVAFVFRTYNIQSLFVVGGFEAFTAVSEVVIPATISNNVPGTEYSIGSDTCLNALIQYCDACRQSASASRRRVFVIETQGGESGYIATVAGLSIGALAVYTPEEGINIKMLDRDIDHLREVFGRDMGHSRSGKVILVNEKASRTYSVQIIADMIAEAGKGKFESRHGVPGHFQQGTTPSPMDRVRAVRFATKAMQHLEQYAGLEPDECEDDPLSVSVIGIKGSKLLFSPMEVVEKKETEWHRRRPKHEFWMALKETVDTLSGRPQAPANPTDIDTLAGRPRGATVTVTHK
84
O14047
2.7.11.1
ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MEKHQYRDLQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSVHITKYYASFVDGFRLWITMEYCDGGSCLDLLKLSGTFSERVIAEVMRQVLEALVYLHGQGKMHRDIKAANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVVKQTGYNYKADIWSLGITAYELATGEPPYSGIHPMKVLLLIPKHSPPSLERSKFSRAFCDFVSNCLKKNPKDRATAEYLSKHKFIKKYCPNTSVKEVVASYAKWKESELLPEATPYNSTMGNSANTIDEVVWDFGTVRR
99
Q7U5E8
2.2.1.2
ACT_SITE 135; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
MATLLDQLSAMTVVVADTGDLEAIRKFTPRDATTNPSLILAAAQIPAYQSLIDEALRSSRKLIGDAAPVEDVVHEALDEISVIFGKEILKIVPRRVSTEVDARLSYDTDATIEKGRKLIRLYNDAGISNDRVLIKIASTWEGIKAAEVLEKEGIHCNLTLLFGFGQAVACAEAGVTLVSPFVGRILDWYKADTGRDSYPGPEDPGVISVTRIFNYYKTYGYKTEVMGASFRNLDEITELAGCDLLTISPKLLDQLRESDASLSQKLDATNPSGGEEQIHVDRERFDAMMAADRMATDKLGEGIKGFSKAIETLEHQLAHRLAELEGGEAFRHAVQEIFMLNDMNGDGCITRDEWLGSDAVFDALDLDHDGRLTPEEVRKGFGAALTLTTA
52
B7P0P3
3.1.1.4
ACT_SITE 411; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 587; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"
VSIPPADGAVSCSLLRTKDQVAAEVSFVQLRDKLPLLLECVPDLLSKDLVQEVVLLVRNNPSWTLAHLAAHLGLVDCFKNQKVAAQICQPAQDTLATPLHIAVRAQKLNSVQVLMGMDAPLNLTDHNGDTIYHAAAVTTKELIKALSVRPAPTAVINQVNNDGYTPLQLACLTDKPECVRELLKEGADVNSASSRGSNCTFFFFFSLGRDHVEQNGHNFQIEDMKHGGTPLHWAKTTQCLETMIELGCDLDAKNFQGNTALHIMVARGRLACVISLLSHGASVNAVGCDGDTPLHAAVRGDVSLIHALIVFGADVNQPNQKGETARHLAATSKLSKRDSVLYTLHAVGARRCDRDQGCSEGCSPEGSFDGVAPEKPNFFKASRREWAGLGGGASAIFLPLKLNRRSLAVGSKWRLTDGRCVAGKTPRQCLQLYFSLKDKMGVGRRRSRELTPMGSKWRLNDGRCVAGKTPRQCLQLYFSLKDKVFIGNRPHDADSLEKFLQREMGETTLMTDIKHPKLMITGVLADRHPAALHLFRNYDSPKKILGVTEDESDFPSCTPPHEQLVWRAARASGAAPTYFRPFGRFLDGGLISNNPTLDAMTEICEYNEALKATVRLWLPFNIFENELFCIFDITYHINIHRDVNVKVRTQQATQANGRLVDRAQAWCRTIGVPYFRLNAPISEDVCLNETDNRLLVRVLWETLVYMRGRRAELDELAQLVRP
130
Q6BXN1
2.4.1.18
ACT_SITE 353; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q04446"; ACT_SITE 414; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q04446"
MSLSTGSTGSERSNQSLIKGALDLDPWLEPFSGQLIHRQLNLRKWYDEFKQNEGSLTNFASAYEKYGLHANWDTKEVFINEYIPNVVEVSLVGDFNNWDTNTHKLKPVNDFGLWSLTIKPTENNEFAVPHDSRYKISMVTASGERIYRLCPWLKRATPSTENNLYEGRFWNPQPTETYKFKHERPRLESKDGIKIYEAHVGISTPEPKVGSYKNFTTKVLPVIHKLGYNTIQLMAVMEHAYYASFGYQVTNFFAISSRFGTPEDLKELIDEAHRLGIRVLLDVVHSHSSKNVEDGLNMFNGTDHYLFHGGTKGSHELWDSRLFNYSNYETLRFLLSNLRFYIDVFKFDGFRFDGVTSMLYKHHGLSFGFSGDYNEYFNSEWVDNDAITYLMLGHKLLDEISVRENNYKFVSIAEDVSGMPTLCLPIGQGGIGFDYRLSMAIPDMWIKIIKHLSDEEWDMGSLVHTLTNRRHGERCISYCESHDQALVGDKTIAFWLMDKEMYTNMSTLTPFTPVIDRGIALHKMIRLITFSLGGEGYLNFEGNEFGHPEWLDFPRKGNGESYAYARRQFNLIEDDLLRYKFLFAFDGAMQHLDTKYGILLSSQAYVSLKNENDKVIVFERNGLLFIFNFHPTNSYADYKIGVETPGVYQIVLNSDSLSFGGHGRIEETNKETGEKLQFFTNNERWNDRSNALFCYIPSRTAIVLQVKEKVV
73
A0A8I6A5T6
2.7.10.1
ACT_SITE 1198; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000617-1"
MGLLLPLLQASLLLMLLLRLPEASTNLDWQCPRIPFAASRDFSVKYVVPSFSAGGRVQATAVYEDSKNSAVFVAIRNRLHVLGPDLQYIESLTTGPIGDPGCQTCASCGPGPHGPPNDTDTLVLVMEPGLPALVSCGSTLQGRCFLHELEPQGEALHLAAPACLFSASNNKPEACTDCVASHLGTRVTVVEQGHASYFYVASSLDPELAASFSPRSVSIRRLKSDTSGFQPGFPSLSVLPKYLASYLIKYVHSFHSGDFVYFLTVQPMDVRSPPSALQTRLVRLNAIEPEIGDYRELVLDCHFAPKRRRRSGAPKSLQAYQVLQAAHSAPVDAKLALDLSISEGQEVLFGVFVAVKDSSSGPNSVVCAFPINHLDNLIEEGVERCCHPSNSSLLTRRRGLDFFQTPSFCPNPPGAPSSRCHYFPLMVHDSFTRVDLFNGLLGSVKVTALHVTRLGNVTVAHMGTEDGRILQVEIARSLNYLLYVSNFSLGSSGQPVHQDVSRLGNDLLFASGDQVFKVPIQGPGCGHFLTCWRCLRAQRFMGCGWCGDRCGRQKECPGSWQQDYCPPEITEFHPHSGPLRGTTRLTLCGSNFYLRPDGVVPEGTHQITVGQSPCRLLPKDSSTRRSGSQKEFIEELECELEPLETQAVGTTNISLLITNMPAGKHFRVEGVSVREDFSFMEPMLTSIKPDFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCRLEQVSEEKILCVTPPGAGTASVPLRLQIGGAEVRGSRTFHYKEDPIVLDISPKCGYSGSHVMVHGQHLTSAWHLTVSFNDGQSIVESRCAGQFLEQQHQCRLPEYMVRNPQGWATGNLSLWGDGAAGFTLPGFRFLPPPSLPRTGPVLLKPEEHSVKVEYIGLGAVADCVTVNVTVGGEVCQHELRGDVVICPLPPSLQLGKDGVPLQVCVDGGCHILGQVVRSGPGRASQRTLLIALLALILLVAGLAIALVCNSRRRKKQLVLTPNLDDLTSRDLSPRAMSLSIFRSGSDYRNGLASRPPNHEESSEGQDGTSVPLLRTDSIRLQDLDKMLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYHGEYTDEAQNQIHCAIKSLSRITEVQEVEAFLREGLIMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHGDLLRFIRSPQRNPTVKDLISFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGILDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLVQGRRLPQPEYCPDSLYQVMLRCWEADPAARPTFRALVLEVEQVASSLLGDHYVQLTAAYVNVGPGAVDDGSVFPEQGQSSPLHHRSTSRPRPLSEPPLPT
97
P45283
6.3.4.4
ACT_SITE 14; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 42; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"
MGKSVVILGAQWGDEGKGKIVDLLTDRVKYVVRYQGGHNAGHTLIINGEKTVLRLIPSGMLHPNVTCLIGNGVVVSPEALMKEMGELESRGIKVRERLLISEACPLILPYHVAMDHAREAALGKKAIGTTGRGIGPAYEDKVARRGLRVGDLFNKEAFAEKLKNILEYYNFQLVNYYKVEPVDYQKTLDDVMAIADVITGMVADITTILDTARKNGEHILFEGAQGTMLDIDHGTYPYVTSSNTTAGGVATGSGFGPRNLDYVLGIIKAYCTRVGGGPFTTELFDDVGAEIARKGNEFGAVTGRPRRCGWFDAVAIRRAIQLNSISGFCMTKLDVLDGFDEVKICVAYKMPNGEIVEYAPLAAKDWEGVEPIYETLPGWKENTFRITDVNKLPQNCINYIKRIEEVTGVPIDILSTGPDRVETMILREPFAA
253
F4IVI0
2.7.11.1
ACT_SITE 347; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MTIGYRDAAGDPLFPWLMEIKNSMEDLYAGKNSGYDLDKLLFDCISTYKKDSRYRNDLRFLKIWFLYLEGREDFERVYREIEETEICKGHSLLYEWYAIFLEVKGLWRRANSVYQTGLSRKAEPFDRLKEAHSLFLQRISKRTKASSLEKVGDDAQATDLETGFVNPWETSTVNGLIHKIKPQLVKYDGYHVSNKVFPGKANLSSLQNYSRNKIIEIGGRKYQMKGCAGQGGFAQVFKAFIDSNPDEVVALKVQKPPFPWEFHMYRQLDCRIPDSQRSSFGLAQRVHVYSDYSILVCDYLSHGTLQDVINSYVVVGKSMEEVLCMYYTIEMLNMLETLHSVGIIHGDFKPDNLLIRYPPENLTETGFHEKTGSWSKKGLCLVDWGRGIDLSLFPRTTEFTGDCRTSGFRCVEMKEDKPWKFQVDTYGLCVIVHMMLHNVYMEIEKKQSLDGGYINMPRTSFKRYWKVDLWKELFTKLLNRETCEDDTETLRNLRKSMEEYICSDPKLMKKLNELLAKQRISLCSS
99
A8I2V3
1.11.1.24
ACT_SITE 48; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MVAKIGAPAPKFKAQAVVNGEIKEISLDDYKGKYVVLFFYPLDFTFVCPTEIVAFSDRVEEFRAINTEVIGASIDSQFTHLAFSNTPRTKGGLGGCKYPLVADLTKQIAKDYGVLIEDGPDAGVTLRGLFIISPTGVLRQITINDLPVGRSVDETLRLVKAFQFTDEHGEVCPANWNPGAKTMKADPTKSLEYFSTLS
12
Q03306
2.7.11.1
ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MTSRKRSPHDFIFKEELGHGSYSTVFKALDKKSPNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHHAGIIKLYYTFHDEENLYFVLDFAPGGELLSLLHKMGTFNDIWTRHFTAQLIDALEFIHSHGIIHRDLKPENVLLDRDGRLMITDFGAAATIDPSLSGDSAKFNSDSNGSKDNQNCASFVGTAEYVSPELLLYNQCGYGSDIWALGCMIYQFVQGQPPFRGENELKTFEKIVALDYPWGPNNRINNSTSPINPLVINLVQKILVIEVNERISLEQIKRHPYFSKVDWNDKIKIWRGIWQSQGQSLQQTTLGLPNIPQNILPTRQLHVIDTPARSIQITKQKRKKPTKISNTTSSIVVWRKRLGISTGKDDLGTVPSTTPAVTAPNDTNVLTNTAAHSTANIALPPNSQSNQVKRAQLVAPNRIPPKVPVINDNVRNKSIPRTKPNVPPLQTSSIPQKLSTSSASSALSAPSTEIRNQDLTHTLDGRNSIDIHVLKQDYVFIYGIPYEHEGPAMSLNSYNKIDNDLITSLVAQHKEELKNSESFLQVLTLKKSGMLSYKNTVMEGNDDQENKEHQMANIEDTDLSMYDFEFNELTRKGFLILEKYKNRIWFISLPSYSTLSKIPFNAVKSSTINNNENWVDCFFRARQLLEEKQILDKISNVSFDSKASSEPSSPPPISRKERPLSIGNNVTTLSYTAKNGSQNNAPQNDNVGEEKPFRIPSSTKDRPGANSTPSSRHPRVLSSNNAGETPKKMNGRLPNSAPSTNTYTNGSVPAFNHRPSTNVGNNKHNILTSKKQGSSVFSPSSSTTKPQIKTTGYRQPTPSPPLPQMEFPTTREKYSAPSNMVISSSRYEVLHTLNNSQTNFDREIASRGASAAFRSLQKSKKKK
99
Q3V129
2.7.11.1
ACT_SITE 121; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MENFVLYEEIGRGSRTVVYKGRRKGTINFVAILCTEKCKRPEITNWVRLTHEIKHKNIVTFHEWYETSNHLWLVVELCTGGSLETVIAQDENLPEDVVREFGVDLVTGLHHLHRLGILFCDLSPGKILLEGPGTLKFSNFCLAKVAGESLEEFFALVAAEEGGGDSGENALKKSMKTRVRGSLIYAAPEIVKGTEFSVTSDLWSLGCLLYEMFSGKPPFFSETVSELVEKILYEDPLPPIPKDSSFPKASSDFLNLLDGLLQKDPQKRFSWEGVLQHPFWKDALRGEDSGWASEDSPFSRNVMECSGPHDSRELLQSPKNGQAKGQKAAHRLSQSFRLENPTELRPKSIMGGQLNESIFLLSSRPTPRTSAMVELNPGEGEDPSSPQKTSPLSKMTSGHLSQGALESQMRELIYTDSDLVITPIIDNPKIMKQPAIKFDPKILHLPAYSVEKLLVLKDQDWNDFLQQVCSQIDSSEKSTGALRAKLNLLCYLCVVATHKEVATRLLHSPLFQLLIQHLRIAPNWDIRSKVARVVGMLALHTTELQENVPVIEAITLLTELIRENFRSGKLKQCLLPTLGQLLYLVATQEEKNQHSRDCWAVPLAAYTVLMRCLREGEERVVNHMAAKIIENVCTTFSAQAQGFTTGEIGPVLWHLFRHSTVDALRITAISALCRITRQSPTAFQNVIEKVGLNAVISSLASAICKVQQYMLTLFTAMLSCGIHLQRLIQEKDFVSTVIRLLDSPSTPIRAKAFLVLLYILIHNRDMLLLSCQARLVMYIERDSRKTSPGKEQQSGNEYLARCLDLLIQHMVQEPPRILGDILNALANVSGRKHPSTVQGKQLKMCLPMMPVVLHLVMSQVFRPQVVTEEFLFSYGTILSHIKSIDLGETNIDGAIGIVASEEFIKVTLSAFEAVIQYPVLLADYRSTVMDYILPPLVSLVQSQNVEWRLFSLRLLSETTTLLVSQEPEDGDEEASCDSDSSLLALIRDELLPQYEHILMEPDPVPAYALKLLVAMTEHNPAFTRLVEESKLVPLIFEVILEHQESILGNTMQSVIALLNNLVAYKDSNMQLLYEQGLVGHVCNMFTETATLCLDRDNKTNTEPASTLLASLLDILLGMLTYTSRIVRQALQVQKSGSRGDTQAAEDLLLLSKPLTDLISLLIPLLPSEDPEISEVSSKCLSILVQLYGGENPESLSPENMVTFANLLMTKEDPKDQKLLLRILKRMVTSNERLLESLKNTGSLLQALERLAPAHRLRGPWAGISCALFQQRAAAQGIPELPPYGIPCCGPSHKRVTGVKLYPC
99
A0A8V0ZKY1
3.1.4.11
ACT_SITE 347; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 392; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"
MASLLCNARECPGRGVRAGRWVESIHPPSWVPEAGGREVPSAMQPALPPGIQLTETLEKMQQGTLMRKVKSKSWKKQRYFKLQDDCMTIWYQSKRTGKTESAFSISDVETVREGHQSEVLQSLAEEFPPERCFTIVFYGRRGNLDLIAGTEEEAQCWVQGLRQLIEVATSMDQRERIDQWIRDWFQKADKNKDGRMNFKEVQRLLKMMNVDMNEDHALRLFQAADKSESGTLEGEEFVLFYKALTEREEVQSLFREFSEDGKKLTLLELVDFLRQEQLEEEGTEELAMELIDKYEPSETARARHALSADGFLMYLCSPEGSIFNPQHRALWQDMTQPLCHYFISSSHNTYLIEDQIRGQSSIEGYIRALKRGCRCLEVDCWDGPNGEPIVYHGHTFTSKIPFREVVSTLGKYAFQASDFPVILSLENHCSMEQQEVLAQQLKDILGEQLLTATTDGRVPTQLPSPEELKHKILLKGKKIGRLEDTLDGPGDEAPDVSDDDNGAEAEEERRRMKKDRESLAQALSDCVVYCKNVSFRGFQEARNHSRPSEISSLSEAKARKLIRDAGNEFVRHNTWQLTRIYPSGMRTDSSNYSPQEMWNAGCQIVALNFQTAGMEMDLCDGLFSQNGHCGYVLKPAFMRDEGTLFNPSDPSTWQGPGPVTLTIQVISGQQLPKVANSKDGAIIDPLVRVEIHGVPADQAHQETKYIENNGFNPHWDETLQFQLHVPQLALVRFVVEDYDKTSRNDFVGQFTLAFANIKPGYRHIHLLSKDGTGIPPSSLFVHIRITEPPGPEQD
153
A0A0A0KUN8
3.1.1.11
ACT_SITE 400; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MNSLPFIFLLLLSLNFAGASVSPPPSTALCKSTLYPKLCRSILSTIRFSPSDPYGYGKFSVKQCIKQATKMSTVIGDYLNRGRDSRLNRPEAGALSDCRDLSDLNVEFLRSIERVLEAAEGVDEELVERVESILSAIVTNGQTCIDGLVESRSSLGNALSGPLLSAGELYSVSLGLVSNAMSRRWKKRREKGGGNGGVPGGGRSREPLDTLIKGLHKMEPCNNQSTKCLGRQRLLTDLGSTGILINNTVVVSSTGADNFTSIGDAIAFAPNNSMPQDGYFVIYVKEGYYEEYVVVPKFKTNIMLIGDGINRTIITGNHNVVDGWTTYNSSTFTVCGDGFVAIDVTFRNTAGPEKHQAVALRNSADLSTFYRCSFEGYQDTLYVHSLRQFYRECDIYGTVDFIFGNAAAVFQQCNLYARKPLPNQKNAFTAQGRTDPNQNTGISIHNCTIKAAPDWVMDSNTTTTNYLGRPWKQYSRTVYMQSYIGDLISPVGWLEWNGTVGLETLYYGEYENYGPGANTSLRVNWPGFSLLNVTQAMNFTVYNFTMGDTWLPYTDIPFSGGLLIK
125
I1NE76
2.7.1.21
ACT_SITE 107; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR035805-1"
MASSSPSSLSLDTAKDLSHSFSEVHVIIGPMFAGKTTALLRRIKSELNAANNVALLKSSKDTRYAIDSVVTHDGIKFPCWALPDLLSFREKYGEDAYQKLDVIGIDEAQFFVDLYEFCCKAADEDGKTVIVAGLDGEYLRRSFGSVLHIIPLAESVTKLTARCELCGKRAFFTLRKTEQRETELIGGADVYMPVCRLHYINSQVAERSVLESENEKTDSLLEAATDV
88
Q9U6D2
2.7.11.24
ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MASTSVPENYYVVPIGETQMVILKRYENLRLIGSGAQGIVCAATDMVTNKPVAIKKLSRPFQNVTHAKRAYREFILMNLVNHKNIIGLLNAFSPQREVEEFNDLYIVMELMDANLCQVIQMDLDHERLSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAVEAFMMTPYVVTRYYRAPEVILGMGYGENVDVWSVGCIFGELIRGRVLFPGADHIDQWTRIIELLGTPEPQFLARLQTTVRNYVENRQKYQPVPFETLFADNMFPPGADNARLTAAKARDLLSRMLVIDPEKRISVDDALAHEYVNVWYDASRGSCSSAGPSTILLVDGEHTVEEWRAMLFAELQNYYRTHDVYGVGQRR
104
B9FDE0
2.7.11.1
ACT_SITE 183; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MGGRVSKAVACCCCRSQHHGVVVESSEKTAEEDHGESYELPAFQEFSFEQLRLATSGFAVENIVSEHGEKAPNVVYKGKLDAQRRIAVKRFNRSAWPDPRQFLEEAKSVGQLRSKRLANLLGCCCEGDERLLVAEYMPNDTLAKHLFHWEAQAMKWPMRLRVVLYLAEALEYCTSKGRALYHDLNAYRVLFDDDCNPRLSCFGLMKNSRDGKSYSTNLAFTPPEYMRTGRITPESVIYSFGTLLLDVLSGKHIPPSHALDLIRDRNFNMLTDSCLEGQFSNEEGTELVRLASRCLHYEPRERPNVRSLVQALAPLQKDLETPSYELMDIPRGGATSVQSLLLSPLAEACSRKDLTAIHEILEKTGYKDDEGTANELSFQMWTNQMQDTLNSKKKGDNAFRQKDFSSAIDCYSQFIEVGTMVSPTIYARRCLSYLMNDKAEQALSDAMQALVISPTWPTAFYLQAAALLSLGMENEAQEAIKDGCAHETSSSSGH
99
A0A1Y1IGG1
3.4.19.9
ACT_SITE 155; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 270; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 270; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
MASLPCLVVLLLSLLVQLGTSAALDLAQAPAAAPENYFRPPHPLTQTPIVGMLTLPVTVPHQLKYGSASFAASYVRWIEAGGARVAPIHYDSSPEELYALLGSVNGVVWTGGLVDFNPTVDDPEGGKYLATTQAILEYVLARNEAGTYYPFWATCLGFERLTQLLARDVNSTIIDTVDAENLDINLNLTPAGWLSRMLGGMSYELFKEVASPLGHLAFNNHGLGITPAKFRGSSAYEYLKILSIDKDRNGKEFVSTVEGRSLPIYGTQWHPEKAAWEWDTRLRLSHVEHAVEFSSYLGSYFANECKFNNHTFASPEAEARALIYNWVPVPTGPITGIKSAYTNIYFFPADHSSWWAKHAKKVTFSLARAFGFEEELDSASG
176
Q9NB31
2.7.11.1
ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MPPSTDSSRRNSEEGSSDGFKLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFIKNAPGCDIMQLMIQDAQEKAILGQAPMAASSGNDATLLSEGMSTMIDGGESTLVQHKDNYVTAQSLRSQMESLRIGGEIPKSAYIPGSSKNGNSPRVQPPGHTASASDPSKNQPFAQDGTGPNFQLGTSESSYKDASYNMMNTEAEYENRFQRAVVDGDFEFLRNITLDELIRRKESLDSEMEEEIRELQRRYKTKRQPILDVIEIKKRLQ
99
A0A1U8JCB0
2.7.1.11
ACT_SITE 248; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
MANLSQPEATNLAAGQNPPPEQQLQDRLDDHAFSFSPITLKKLPHLSDYLQDLRPAGPNPLDHNPFFHPSDGFYVNTSDIVLRQVACRLSPSGTIASPSHHLAYIRAGPRKQIFFDHCATRAAIVTCGGLCPGMNTVIRELVVGLWDLYGVRQIYGIKAGYRGFYSIHPIELNPKMVHNWHRRGGTVLETSRGGFDLTKIVDAIENHGFNQVYIIGGDGTMRGAVKIFEEVRRRKLKVGVTGIPKTVDNDVGIIDRSFGFQTAVEMAEQAIHAAHVEAESAVNGIGLVKLMGRSTGHIALHATLSSRDVDCCLIPETEFYLEGKGGLLEFLEQRLKERGHAVVVVAEGAGQDLIPRTTAQKEERDESGNMVFLDVGAWLKTELKKWWDREHPHELFTVKYIDPTYMIRAVPANATDNLYCTLVAHSAIHGLMAGYSGFVTGPINANHAYIPLADVAQARNEVNIKDHKWEWVRSITNQPDFVKSKQNSA
84
A0A060X7Z0
2.7.1.11
ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184"
MSHTSMDPTKMGIGRSIAVLTSGGDAQGMNAAVRATVRVGIYTGAKVYFVHEGYQGLVDGGDNIKLATWESVSMMLQLGGTVIGSARCMDFRAREGRMKAALNLVKLGITNLCVIGGDGSLTGANQFRKEWATLLVDLVKAGKITDDEARKSCHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAITTTAQSHQRTFILEVMGRHCGYLALVTALACGADWVFIPEMPPDDGWEGHLCRRLADQRARGSRLNVIIVAEGAMDRAGNPISSEDIKKASSTSYYFKVLRFYCIVMLVEKNLGFDTRTTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEATPETPACVVSLSGNQAVRLPLMECVQVTKDVTTAMAEKRWEDAIKLRGKSFENNWNTYKMLAHINPPDTKSNINVAIVNIGAPCAGMNAAVRSAVRIGIIQGHNMLAVHDGFEGLAQGKIEPITWTGVSGWTGKGGSELGTKRVLPSEYIEEISLTIAKFNIHSLVIIGGFEAYMGGLELVQGRDKYEELCIPMVVIPATVSNNVPGSDFSIGADTALNTITSTCDRIKQSAAGTKRRVFIIETAGGYCGYLATMAGLAAGADAAYIYEDKFGIRDLEMNVEHLVQKMKTDVKRGLILRNENCNANYTTDFIFALYSEEGKGIFDCRKNVLGHMQQGGTPTPFDRNFGTKMGSKAVLWITEKLKEVYRHGRIFANTPDSACVLGMKKRALTFQPLAELKEQTDFVHRIPKTSWWLKLRPIMKILAKYNISLDTSEHAHMEHVIKKRVSMPAPLMKKACPPTKHEEEE
84
Q9W462
3.4.19.12
ACT_SITE 48; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 506; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10093"
MESEKILMAAGVTVAAVVGAFVFWGPSGSRLRQRRGQIAGLHNFGLTCFLNTLLQAMAACPQFIAWLQLYNNASPDRKSLITSMLNTLEVVNGTHATLRGDPYSPGAVLRALNALGWVIPQEEHDAHELFHVLLTCLEEEAIRPQPLGCLSDALPTDNDDNSSLAGTATPVGGFRSFSSMAAGLGASQRIGDQPNRPSSAMLTDFLNMEYDESTSLQRLVRSEAHTPDSPASVCERDGNDRLGSVLLDAVSPGTPFGFPLVSNPDSLATPMLGGERSSRPRLPQSQQQQDEGLNRRVSSSCRSLERLHRGPGRVSIWSNMMPSQVAHPFQGAMGAQIVCNGCGSKSAVRYDKFDSITLNLPPQRRTGLSLGHLLSEYITSEDLSDVKCDSCNETTTHTKSVTFAKLPACLCIHVARTVWLPTGQVCKRKDYVHFPESLSMAPYSFVQPHLNSQAGTPWGSTMSLYSSSLPMNNGVGGGEGFGTMFPKNLYRLLAVVVHSGEANSGHFVTYRRGSLRNAHRWYYTSDTIVREVSIDEVLSVPAYLLFYDRGQQRQLNLR
175
Q9LFS4
2.7.11.1
ACT_SITE 435; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MESTIVMMMMITRSFFCFLGFLCLLCSSVHGLLSPKGVNFEVQALMDIKASLHDPHGVLDNWDRDAVDPCSWTMVTCSSENFVIGLGTPSQNLSGTLSPSITNLTNLRIVLLQNNNIKGKIPAEIGRLTRLETLDLSDNFFHGEIPFSVGYLQSLQYLRLNNNSLSGVFPLSLSNMTQLAFLDLSYNNLSGPVPRFAAKTFSIVGNPLICPTGTEPDCNGTTLIPMSMNLNQTGVPLYAGGSRNHKMAIAVGSSVGTVSLIFIAVGLFLWWRQRHNQNTFFDVKDGNHHEEVSLGNLRRFGFRELQIATNNFSSKNLLGKGGYGNVYKGILGDSTVVAVKRLKDGGALGGEIQFQTEVEMISLAVHRNLLRLYGFCITQTEKLLVYPYMSNGSVASRMKAKPVLDWSIRKRIAIGAARGLVYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHQDSHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELVTGQRAFEFGKAANQKGVMLDWVKKIHQEKKLELLVDKELLKKKSYDEIELDEMVRVALLCTQYLPGHRPKMSEVVRMLEGDGLAEKWEASQRSDSVSKCSNRINELMSSSDRYSDLTDDSSLLVQAMELSGPR
99
A0A0Q3PR06
1.11.1.7
ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MANASRRPATATMALLLLLVLLELAAMTGLSQGQLQVGFYSESCPDAEDIVSSAVQDAAASDPTLLPALVRLQFHDCFVRGCDGSVLIAGAEVKNSKHQGLRGLDVVDAAKALLEEQCPGVVSCADVLALAARDAIGMTNGPSFDVPTGRRDGLASNVRDADVLPDASDNIQTLRSKFATAGLDDRDLVLLTAAHTIGTTACFFVKDRLYGASGSDPGIPAGYLAELKARCAPGDFNTRVPLDRGSEARFDGSILRNIQAGLVPIASDAALVADNATAALVGAYIGSPRFRRDFVGAMVKMGTIGVITGGNGEIRDVCSAFNTN
14
G5EFD2
2.7.11.1
ACT_SITE 600; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MMQTQVASRAGYSNLPQFGAGIAQDIKTQAINNLKECLKLTTINRFLTSSYEEDAKSVERKIFSAVYQMTKIGLIDREKREINAIWFTFVGLSAQNIRHLEICSITDFNALFSITNQELRSLADRGRLDVETKRKLLQSTVILQNHWNAYHSRTSSGSTDEPSGQSTPAIVTPSPKFNVPSLSVTSAKMIQSSSMGFATTPKSPKTSSRLVHAIPHKWHRSTKFRFSGDAVCHFCQRPLGFGFLNAWEKCRSCKWKVHTQCKGRVGDSCGLTPDHLRFLFDKLIQENNGGMWKDPQSVPGSRSMNEPAFQFPDTAIDSSSSTNSSAPSTPALPAGISGNVSSLTAPYRSERKFLFPDTENYSVHNRLPILVISEGDHPTTTEIQQETENHNKSAAASMSGNIESEGTIVANHEDSTGSQEVDSEAAPSQEAVDKFNKRADGGFTWERHAWNMSTIRGPNAQASWNEVTIQFETIEFDKQAPIIGRGRFGKVLRGFHYGDVAVKVYTMEHISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFMSDGQYGMVMSLSKGSQSLYTLLHVVREKLDLATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKVVITDFGILSMKRLAHPKQKSGYLTSKFWTNYIAPELAMAMRTEYDEYECDDFPFSENSDVYAFGCVWFEMLTGALPYAGELPHQILFAKTQGIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLKLTALPKKPRVNRSPSFPVMMKSYESTF
99
Q7NJ09
3.4.21.89
ACT_SITE 57; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 102; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
MVEHPNSTEPSRPSVAHGFWRWFSSQRENLQTIVLAVFLALFIRSFVAEARYIPSGSMEPTLRIDDRLIVEKLSYEFQQPERGQVIVFTPPKRTNIDQAFIKRVIGLPGDTIEVKNGKVLLNGRTLNEPYIATPPAYILPRQKVPAGHFFVMGDNRNNSFDSHLWGFLPRQNVIGRAVFRFWPLERVGAIE
178
P0A744
1.8.4.11
ACT_SITE 52; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000269|PubMed:10964927"
MSLFDKKHLVSPADALPGRNTPMPVATLHAVNGHSMTNVPDGMEIAIFAMGCFWGVERLFWQLPGVYSTAAGYTGGYTPNPTYREVCSGDTGHAEAVRIVYDPSVISYEQLLQVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAAMLAADDDRHITTEIANATPFYYAEDDHQQYLHKNPYGYCGIGGIGVCLPPEA
39
P21696
1.1.1.8
ACT_SITE 232; /note="Proton acceptor"; /evidence="ECO:0000250"
MSGYGQQGVSAANIDSIRPKKRLSIGVVGSGNWGTAIAKICGENARAHGHHFRSKVRMWVFEEEIEYKGEKRKLTEVFNEAHENVKYLPGIECPPNVIAVPDVREVARRADILVFVVPHQFIERVCDQMVGLIRPGAVGISCIKGVAVSKEGVRLYSEVISEKLGIYCGVLSGANVANEVAREQFCETTIGFNPPNEVDIPREQIAAVFDRPYFSVVSVDDVAGVALGGALKNVVAMAVGFADGLEWGGNTKAAIMRRGLLEMQKFATTFFDSDPRTMVEQSCGIADLVTSCLGGRNNRCAEAFVKTGKSLETLEKELLGGQLLQGAATSKDVHEFLLTKDMVKDFPLFTAVYNISYEDMDPKDLIIVLQPLKEDSENEGGTETE
7
A2F9H1
2.3.1.286
ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236"
MSEDRKLKSFDMDGVVDYIKSGKAKKIIFLTGAGISTAAGIPDFRSIGTGFYSNLQKYNLPEPSDVFNIKYFKENQEPFYDLCPSLLPGKYKPTFIHYFGAYMAKKGILLKQYTQNIDGLERIAGVPEDKLVESHGTFSTAHCTECKKEWKLEEIRDKLLLGKPLHCTDPDCKGFIKPDIVFFGENLPTSFQHNARIDLRSCDMLLISGTSLKVNPFASLPGTAPEDVPRVLINLDKVAQYTEEEMDMGGEIVKVTPPNFRSLLRYDHPSNTRDVYLGGDCQETFKELARRLGWYDDIIAMMPK
58
O74201
2.3.2.23
ACT_SITE 88; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133"
MSTPARRRLMRDFKRMQQDPPSGVSASPLPDNVMKWNAVIIGPSDTPFEDGTFRLLLSFDEQYPNKPPQVKFISEMFHPNVYASGELCLDILQNRWSPTYDVSSILTSVQSLLNDPNISSPANVEAANLYKDHRSLYVKRVRETVENSWNDDDDEEEEEEDEDEAEDEDDDDDDNIDED
64
A0A2I4FD37
1.11.1.7
ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAPIVALFPSLVLMMVFSSFSQRADSLSLNYYEKTCPNAESIVTNAVKSAVSKDKTVPAALLRLHFHDCFIRGCDASVLLYSKGSNKAEKDGPPNVSLHALYVIDSAKKELEAWCPGVVSCADILALAARDAVSLSGGPSWEVPKGRKDGRTSKASETTQLPAPTFNISQLQQSFSQRGLSMDDLVALSGGHTLGFSHCSSFQNRIHNFNSTHEIDPSMHPSFAANLKSVCPKNNKAKNAGTAMDPSSTTFDNTYFKLILQGKGLFSSDQALLDFPKTKDLVSKFASSREAFTKAFVNSMIKMSSITGGQEIRKDCRVVN
14
A0A1U8B161
3.1.1.11
ACT_SITE 406; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MATQFFSISYFISLYVVLLLSFSHLSLAIVPPSANVSQDAACRSTPYPYFCKSVLPRNENRNITDYGRFSVRRSLSAARKFLGLVDRYLRNRSNLSQAAIRVLEDCRLLAGLNIDFLFSSFKTLNSTKILPSLEAEDVQTLLSAILTNQQTCSDEIQVTESAWRVRNGMSLPLSNDTKLYSVSLALFTRGWVYKHKGKRRKPKPGRKLIFSDMEVVRHGHLPLRMSRRNREIYEYVGRRKLLQNSMESVLVRDIVVVSQDGNGNFTTINDAVAAAPNNTKIDDGYFLIYIVGGVYEEYVSIAKNKKNLMMIGDGINQTILTGNHSVGDGSTTFNSATLAVVGQGFVAVDITIRNTAGPAKGQAVAVRNGADLSTFYSCSFQGYQDTLYTHSLRQFYRECDIYGTVDFIFGNAAVVFQNCNIYARQPRKGQGNAITAQGRTDPNQNTGTSIQNCSIKAAADLVASNFTTKTYLGRPWKEYSRTVYMQSFIDSLVEPSGWSIWTGDFALSTLYYAEYNNWGPGSNTSNRVTWPGYHVINATDAANFTVSNFILGDAWIPATGVPYYGGLL
125
P0CD62
2.7.11.1
ACT_SITE 825; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MDSRCGVCKYIISDCERYVSDNTFYHVKCFICKICKCELPPCFRGKHASLMCGDCEIKLNAPKCFKSHFPIHSVSVVARNKEFHNNCFTCISCNEIIKGGFQYSDELFYCSKCDIIKPPPLPPPLIYKAPIATSKATTSITSPLPTKIPILSTANLIPPLSSSSPLATQISPKTSTIATTTVETTTAETTLPSPFKISQLKNSGDNIYSLSSPSSSSSSSSSSSSSSSSPPNTFNKSSDFLRNPLNNNVKSSSSSIGGNFVNKSQQQQQPIDSCSKSSISISPSSPRPTEDDIKEQVFLLQKQSVQLQIQQQLQQRQIEQLNKNQLGVQKPLNQQPQQQQQQFKPQSPNLSNNDTLDSFSNLNQSLPPPPLINTTTFSNPLLKTKNQSFPTPPTSHIIKENQSQQIPKPSSIDEVDQLPLPPPPITPIPSPSSSSIIINNQQQQQQESQLPPPPPTSIIIDQSILLPPPPPSTEILPQQQSPKLYKPRPKPIVLPPPPLDMEQLPLPPPPLLSSQINQSLKSTQHNQTTSPTIEIPIPPPLPIQKQSIPTRKPQLPQSSNPSPPSPPSPQPSSNIPPLSPKQQQEQQVEPIFSPTGSIIPTPPPPPPIFKMKPLRPQKFRAPTNYIPSLSLHRANKLSNSTEDHIKPPESLVLESSRIEKFEPTINGRKLTELLKHQTFDDIVGEVLNKRISIYKQLVKDDVIFGDVIAAGASGKVYKGIYKGRDVAIKVYSSENFCFNIDEFDREVTIMSLIDSDHPNFTRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKEKPLLYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKHMTMNLGTSCYMSPELFKGNGYDETCDVYAFGIVLWEIIARKEPYENINSWSIPVMVAKGDRPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDTLKKISESLTLKRNKK
99
B8BVD6
3.4.21.92
ACT_SITE 96; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 121; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086"
LVPVVLESGTTGERAFDIYSRLLRERIICVHGEVTDSMASLVTAQLLFLEAEAPEKPVYMYINSPGGLVTAGMAMYDTMQYIHPEVHTICMGQAASMGSLLLAGGSAGCRFALPNARIMLHQPSGGAQGMASDIDIQAREILRTRANLNQLYVHHTGRELEEIERVMDRDTFMDVRQAVDFGVIDEVLTKR
179
M1AM70
2.4.1.18
ACT_SITE 429; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 484; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MEINFNVLSKPIRGSFPSFSPKVSSGASRNKICFPSQHSTGLKFGSQERSWDISSTPKSRVRKDERMKHSSAISAVLTDDNSTMAPLEEDVKTENIGLLNLDPTLEPYLDHFRHRMKRYVDQKMLIEKYEGPLEEFAQGYLKFGFNREDGCIVYREWAPAAQEAEVIGDFNGWNGSNHMMEKDQFGVWSIRIPDVDSKPVIPHNSRVKFRFKHGNGVWVDRIPAWIKYATADATKFAAPYDGVYWDPPPSERYHFKYPRPPKPRAPRIYEAHVGMSSSEPRVNSYREFADDVLPRIKANNYNTVQLMAIMEHSYYGSFGYHVTNFFAVSNRYGNPEDLKYLIDKAHSLGLQVLVDVVHSHASNNVTDGLNGFDIGQGSQESYFHAGERGYHKLWDSRLFNYANWEVLRFLLSNLRWWLEEYNFDGFRFDGITSMLYVHHGINMGFTGNYNEYFSEATDVDAVVYLMLANNLIHKIFPDATVIAEDVSGMPGLSRPVSEGGIGFDYRLAMAIPDKWIDYLKNKNDEDWSMKEVTSSLTNRRYTEKCIAYAESHDQSIVGDKTIAFLLMDKEMYSGMSCLTDASPVVDRGIALHKMIHFFTMALGGEGYLNFMGNEFGHPEWIDFPREGNNWSYDKCRRQWNLADSEHLRYKFMNAFDRAMNSLDEKFSFLASGKQIVSSMDDDNKVVVFERGDLVFVFNFHPNNTYEGYKVGCDLPGKYRVALDSDAWEFGGHGRAGHDVDHFTSPEGIPGVPETNFNGRPNSFKVLSPARTCVAYYRVDERMSETEDYQTDICSELLPTANIEESDEKLKDSSSTNISTSSTKNAYYRVDERMSEAEDYQTDICSELLPTANIEESDEKLDDSLSTNISNIGQTVVVSVEERDKELKDSPSVSIISDAVPAEWADSDANVWGED
73
A7SAZ2
2.7.11.1
ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 512; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
ANLTEAQDEKVGIENFELLRVLGTGAYGKVFLARKRGGHHDGRLFAMKVLKKATIVQKAKTAEHTRTERQVLEAVRRCPFLVTLHWAFQTEAKLHLIMDYVNGGELFTHLYQREKFTEDEVRLYIGEIVVALDHLHQLGIIYRDIKLENILLDKDGHVVLTDFGLSKEFAAPNSGERAYSFCGTIEYMAPEVVKGGSRGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQSEISKRILHNNPPMPHDLSAEAIDLLHKLLQKDPKKRLGAKGAHELKAHPFFKAFDWADLAEKRIPAPFKPRIRDELDVSNFSEEFTDMAPTYSPAAVPKTADRVFRGYSFVAPSIIFGENEFNQQPVQRKNEVNAVPVQRRPAQGLVDYASMFEGSHFFQNYRITSQVLGDGSFSTCRRCVHLRSGQEYAVKIISRRCDHTREVQSLKMCHGHPNIVTLYDVYQDEFHTYLVMELLAGGELLERIRKKKMFTESAASVIMRKIVSAVEFMHQRGVVHRDLKPENLLFVDNSEDAEIKIVDFGFACVKPEAQQLQTPCFTLSYAAPEVLDQTVSNSGYDESCDLWSLGVILYTMLSGQVPFQSSGSWYKSSTGFVMQRITQGDVRFDGQQWQSISPQAKDLIQGLLTVDPSQRLTVQEVLRHDWLRVETSLPHTPLVTPGILERGKKRTYVESALNVTYNAFNKAQRQGFTLMDVENAPLAKRRKLKKTTSSDSYSTTSTCSDLSNPGGVSPPSNNR
99
F7A0P0
2.7.11.1
ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
EKASTSGRATASSAKDNASDTWSLKNFDIGKPLGRGKFGSVYLAREKKSKFIVALKVLFKSQLMKSNVEHQLRREIEIQSHLRHPHILRLYGYFHDETRVYLILEYASRGEMYKELQKQGKFTEEMSATYIAELADALNYCHSKQVIHRDIKPENLLMGLRGELKIADFGWSVHAPSSKRQTLCGTLDYLPPEMIEAKDHDANVDLWTLGILCYEFLVGKPPFETKSTQETYLRITSLKYSFPPHVSEGARDLIRRLLKLEPRHRLPLESVMAHPWIKANAKPARRYASYKNAS
99
A0A803SY32
3.1.4.11
ACT_SITE 356; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 401; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"
MICGKWKKSRSESHRRGRHRHHQQQPPPPQTEPPVPAQTYGGVAAAAAKLSGHRAFKKLGLTDDDDIKVMLRGSFFWKVKTHRPRKQRLYRLQEDGMTIWFETRFKKAYSQHVFSILHIESVREGYQSEGLRKYGGCFPEDQCFTIVFRGKRKNLDLAAISVNEAQQWVRGLKKLMARGEAMSQREKLEHWIHDMLHQADKNKDNKMSFKEIKNMLRMINIDMNDIYAYRLFKECDRSNNDRLEEYEIEEFCTRLMERPELKEIFHRYSGEDCVLSAEELREFLHDQGEEATIKRATDIIQTYELNERARQHNLMMLDGFMMYLLSSAGDVLNQNHTEIYQDMSQPLCHYFISSSHNTYLTDNQIGGASSTEAYIRALMKGCRCVELDCWEGSNGEPIIYHGHTLTSKILFRDVIESIRDYAFKHSSYPLILSLENHCGLEQQSTMARHMKAILGDMLLTQPLDGDVPKQLPSPEQLKWKILVKGKKLPEGKNELDRCNFSNPEEEMQDEEDDRSISSLQEIKPLQAKDAIQISRELSDVVVYCQAVPFQSLSRALHNQQSNEMSSFSERKARKLIKESGNQFVRYNTRHLSRIYPQGLKVNSSNYNPQEMWNAGCQLVALNFQTPGAEMDLNDGRFSVNGSCGYVLKPAFLRNTQSSFDPEAPGRRAGQRPVALTIKVITAQQLPKLNKEKNSSIVDPFVRIEIYGVPVDCCKKQTEYQLNNGFNPRWNETLTFQVRIPELALVRFVVEDYDTTSANDFVGQFTLPLLSLREGYRHIHLLSKDGTSLSPATLFVHVRCKKM
153
Q9I165
3.2.1.28
ACT_SITE 320; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01060"; ACT_SITE 503; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01060"
MPDRTALPRAMLAAWVLLLLAACSQGPAPTPPASWGWQDASGERAIAPDEAYPELFQAVQENRLFSDQKHFVDALPLREPARIRADYLRERERPGFDLRAFVGRNFEESGSVETAPPEAGADLASHISDLWPALTRHYEQVPAHSSLLPLPKPYVVPGGRFREVYYWDSYFTMLGLAESGQHQRVRDMLDNFAYLIDTYGHIPNGNRSYYLSRSQPPFFAYMVDLQARREGDAAYRRYLPQLQKEYAYWMEGSAGLRPNEARLHVVKLADGSLLNRYWDNRDTPRQESFLEDRATAARAPQRPAGEVYRDLRAGAESGWDFSSRWLDDGRELASIRTTAIVPVDLNALLYHLERIIAKACASSALKACEQGYGARAEKRRQAIEDHLWHPAGYYADYDWQRRRPIERINAASLFPLFTGLASAERAGRTADSVAAQLLRPGGLATTTRASGQQWDEPNGWAPLQWVAVQGLRAYGRDALAEDIGRRFLAQVQQVYDREGKLVEKYDISGNQGGGGGGEYPLQDGFGWSNGVTLQLLRLYGPGAGR
165
A0A7M7NGF1
2.3.2.26
ACT_SITE 874; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MRMNPSREIDNASREEAVETEVEGSITDGGSASSDEMKRSQARGLIERYFYQLTNGCGNAGCCNEFCASSGRQTHLSSNEAAAMALDLFKRKATLCESAPNKQLKTGDVEDQSDGTTPMDVSPAAQPSTSFARNTPSTSSSDGDKQTLLPKPLDTQRSSSESDSIKDIYFLTEAKILEILKQCMESKNFSPLVRVIGRVFSCWQSLNKSFLRTVKQGLSDKERKQRDDKETDEMDEGLQSISTRLADHDLGECSSKATDTLEVDMESVQRVYEAITKLDEERVNNAMLNAVTSLAQMADVEVIVNPLFQDGSNQLNFIIITMENPMMSSPEYLEVAFPTFCRALSHLPLAASCNLAKVWSKFSPVSLTRKVQALQQLITFKVLSGHFNSGPRRITVNEDDAITSATDCMKILYYACILGGVVEHQSRLSKEEEELNLQDFLGALGHENKERKPPKEDSFAKKLGLTVLDCRKPLIPFSEFYNEPLNDQLEVDHDFTCYKKESDGRFAFLNYPFILTPATKSTGLYYDSRVRMFHERRLTLLNSLVQGEEINPYLKLKVRRDHVVDDSLVRLEMIAVDNPMDLKKQLYVEFEGEQGVDEGGVSKEFFQLVIQEIFNPDIGMFTHNSDLQTYWFNPTSFETNRQYTLIGILLGLAIYNNVILDVTFPMVVYRKLMGRRGVFADLHDAQPVLYNSLKALLEHEDTVEETFMMNFMISYIDVFGNTITHDLKENGAQIPVTVENRKEFVDLYADFILNRSIEKQFREFRRGFDMVTDESPLRNWFRPDEVELLVCGSKNFDFNELEKATEYDGGYTSTSPTIRYFWEIVHSMDEDQKRKLLMFTTGSDRVPVGGLAKLRLILAKNGPDSDRLPTSHTCFNVLLLPEYSSKAKLEERLLKAITHAKGFGML
65