Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0CLA9 | 3.2.1.52 | ACT_SITE 312; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MKFIIVIAILIVGTYQLMPMPKQFVKGSKSMKVINKCGIQFTNGNQYPEHVIELLRHYHSLMTSKNECNFEQALNFNLKNQGALKFHISLQNDEQLYWVNKTQQEAYILKIDEYLNIQIDAHNHWGLARALDTVHQLTENDRIEFLPLIIEDEPAYSFRGVMVDTARHFLPLKTLERTIDALAINKMNVMHWHITDDESFPLLLTNYSRITHTSKYSENEYYTKSDVSYLIEYASIRGVQIIPEIDSPAHVQSWGRNISDLEYIILNCGSTIKQYGQFDPTLDLTYDVVKSVFQDLSDMFSKVQFIHFGGDEAIKSCYNQ... | 170 |
Q6GP31 | 3.1.3.48 | ACT_SITE 459; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000929-1" | MTSRRWFHPNISGQEAETLLLTNGGHGSFLARPSKSNPGDFTLSVRRHNEVTHIKIQNTGDYYDLYGGETFATLAELVQYYTEQQGLLREKNGDVIELKYPLNSQDPTSERWYHGHLSGKEAEKLLLEKGKPGSFLVRESQSKPGDFVLSVLTSEEKLENGERKSRVTHVMIRFQPDGKYDVGGGERFDTLTDLLEHYKKNPMVEKSGAVVHLKQPFNATRINAASIGTRVRELNKTADNTEKAKQGFWEEFEMLQQQECKLLYPRKEGQRLENKSKNRYKNILPFDTTRVTLRDTDESIAGSDYINANYIKNTLDEVHG... | 149 |
A2C524 | 1.3.3.3 | ACT_SITE 118; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MSSSQDKANLPANNSRARAKKLVLELQDEICAGLETIDGEGKFLEESWERPEGGGGRSRVLKDGKIFEQGGVNFSEVHGNELPPSIISQRPEAKGHSWFATGTSMVLHPKNPYIPTVHLNYRYFEAGPVWWFGGGADLTPFYPYLSDTRHFHSCHKNACDTIDKDLHKVFKPWCDEYFFLKHRNETRGVGGIFYDYQDGSGLLYKGQNANGKASKIAKELGEYSLNWENLFSLAKACGQAFLPSYEPIIKKRKNQSFSTKERDFQLYRRGRYAEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKPEENSREAL... | 27 |
T1FGH8 | 4.6.1.16 | ACT_SITE 221; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 229; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 306; /evidence="ECO:0000256|PIRSR:PIRSR011789-1" | MTIGKHFLKHHLHQVRKLFCKKMQPSVRLKEPRRKRARAQAAHQEPLPVSLQCSQASTFNNWKVCKGFYDGGSVLVHDLDEIEFIYINGFFGKGAHSRGPPELLAEYLEADERFLIPCKKKRNDIEDDGLPPLPFPTLPSSDVHEPLVLSLCEAFFLTYGLGCLVIYDDQKQKPMSILRTWRLFMNFDPNFVVTYAAYHYLRSKGWVVRSGVKYGSNFVLYKDGPAFYHSTYSVVVKPVLHNSNDNIIHVGNSSNNNNSNNNNNNDNNNNHMKSNNNVDGDGDDPCAISDWTSLSRLNRITEQVAKDLVICYVIQPDNNN... | 207 |
Q20480 | 2.3.1.286 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MAQKFVPEAAELCENSLKKFISLIGTVDKLLVISGAGISTESGIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRNFLAWPRFGQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGENVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPTRADHMATMKLDYKISDVLKEM | 58 |
T1EM77 | 3.2.2.27 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MKLTSMRTFGLVNNIGPSWFYALEAEFTKPYFEKLSKFVRDERAKYTVYPPVSQVFSWTQVTPIHEVKVVIVGQDPYHQPNQAHGLCFSVQKGVDIPPSLKNMYKELEQSCPPFRHPGHGYLMGWAEQGVLLLNSVLTVRRNEANSHKDAGWELFTDAVMNWLNFNLSGVVFMLWGSYAHKKGDKINKTRHHVIKGVHPSPLSAHRGFFGCGHFKMCNELLKKQNKPEINWNHLP | 173 |
Q5KP44 | 1.1.1.205 | ACT_SITE 345; /note="Thioimidate intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_03156"; ACT_SITE 458; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03156" | MADTNPNAPPRSDSLLNPADALKYLEEYPRGDGLSLQELMDSRKNGGLTYNDFLVLPGHISFPASDVSLQSRATKNIVLNTPFLSSPMDTVTEDRMAIALALHGGLGIIHHNCSAEEQAAMVRRVKKYENGFITDPLCLGPDATVGDVLEIKAKFGFCGVPITETGAPNSKLLGIVTGRDVQFQDAETPIKSVMTTEVVTGSSPITLEKANSLLRETKKGKLPIVDSNGHLVSLVARSDLLKNQNYPYASKVPESKQLYCGAAIGTRPGDKDRLKLLAEAGLDVVVLDSSQGDSVYQIEFIKWIKQTYPKIEIIAGNVVT... | 3 |
B8DYL0 | 1.1.1.49 | ACT_SITE 228; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966" | MNNKFIIVIFGGLGDLAQNKLYPVIYSLYKKYRLLNCTKIISTGRRPNVDKEEFLKILEKSIKTHDDSFFSLFDFVKFDLEKEEEYNHLKNMLSNFKEEEFIFYLATPPTTFETIIKNLGEFLKSFPNKRKIVIEKPFGYNLYSAQKLNQLIKIYFKEEEVYRIDHFLGKETVQNIFGLRFSNIIFEGIWNRNFIDHIQISALEDIGVEGRLGYYDKVGALRDMIQNHLIQILSIVAMEPPCCINEKEIRDEKIKVLKSIREIKREDVPLYAVRGQYEGYLIDENLSQSNTETYAAVKLFIENLRWDGVPFYLRTGKKLK... | 6 |
Q5A6B6 | 3.1.3.16 | ACT_SITE 123; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P36873" | MTVPFKIPISDLDYCLEQLLDHKPPKILPPETIQQLCHTLKTELLQTPNIISLQSPISVVGDIHGQYHDLLEIFQIGGSPPQTNYLFLGDYVDRGYYSVETISLLLVLKLRYPERVFLIRGNHESRTITTNYGFYTEVLNKYQGSADVWTFITDLFDYLPLGATIDGKIFACHGGLSPSCQQLDQIRAVDRFREIPHDGIMADLVWSDPDVAISDFKLSPRGAGYLFGNDVIDKFCQDNNLVQMIRAHQLCNEGYTSYWKGKCLTVWSAPNYCYRCGNKASVLEILHSNYDSKDPTNGSDGEISSINGEFIGVNTSFESF... | 144 |
H1AE12 | 3.2.1.45 | ACT_SITE 258; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O85465"; ACT_SITE 492; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O85465" | MSGIQFDVSRLCAATISIQGRHFVDSHGRVLHLRGANVSAASKVPATPAPKIHDHAQASYVGRPFRLEEADEHWARLKSWGLTFVRITVTWEALEHKERGVYDEDYLAYLRALLQSMEPYGLVAYIALHQDVWSRYCGGSGAPGWTLEAAGFDLSNEGENLSLSGAAFLDGIKSGRLAGERGLWPTGYQKLAAATMNTLFWGGETFAPLLKVPGQIDGKWVSRNIQVYLQEAFLAATAKLVKAVGDLETVMGFELMNEPHPGFIGIQSIHEWDYTTDLHLGQFPSPLQSFSMGAGHPTPNVPVYTRSFPFPTRVTSHVTA... | 168 |
A0A9J7KSH8 | 2.7.11.1 | ACT_SITE 161; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 529; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MAQAALSDSGFVRLELKHANLTGHPEKVGRESFELLKVLGTGAYGKVFLVRKISGHHAGKLFAMKVLKKATIVQKSKTAEHTRTERQVLEAVRQCPFLVKLHYAFQTDVKLHLVMDYISGGELFTHLYQREYFTEAEVRVYAGEVVLALEHLHKLGIIYRDIKLENILLDKEGHVVLTDFGLSKEFLPGTEGRAYSFCGTIEYMAPEVVKGGHEGHNKAVDWWSLGVLIYELLTGASPFTVEGEKNSQSEISKRILKTNPPLSRSFSAEVKDLLMKLLMKDPQGRLGSGSRGAEDVKEHPFFKGINWEDLSAKRTPAPFT... | 99 |
H2LZI2 | 2.7.10.2 | ACT_SITE 682; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000632-1" | MGFGEDLWCPQAHTAVMGLLDSELHLMEVMKKWMGQRAKSEREFSVQLHSMTALVEKMDRPQNGQDYISQLNKSWEVLVLQTESLSQLMKMRSEDLLNGPISKLTLLIRDKQQLRKNYAEQWTLLRQELNKVTNTELERLKSSYRQAVKDVAQAKRKHQDASKDKDRDKNRERYIKASVKLHELHNEYVLSVRAAQVYHQHHYSQIQPALLSAIQNLQQEMVLILKEILQEYFDISTLLHHDVVRIHREMSNVLTVINPSKEYESFVHQNRSMGEIPACADFDCSLLEDSENLKPREIELNNLTYERIQHKLTAIEEELL... | 98 |
F4J0D2 | 2.7.11.1 | ACT_SITE 259; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MATKLESFKVVEKLGVEKGEKGKMMSKKKNVKKDGDESESGFWFRFKFIFSCISSRSKVDSSMNATAVIAEPKKVIEKLEGHPAPTKDTGCAESGSSTPLMSGELKYSSKLRIFMFNDLKLATRNFRPESLLGEGGFGCVFKGWIEENGTAPVKPGTGLTVAVKTLNPDGLQGHKEWLAEINFLGNLVHPSLVKLVGYCMEEDQRLLVYEFMPRGSLENHLFRRTLPLPWSVRMKIALGAAKGLAFLHEEAEKPVIYRDFKTSNILLDGEYNAKLSDFGLAKDAPDEKKSHVSTRVMGTYGYAAPEYVMTGHLTTKSDVY... | 99 |
Q7XSU7 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGAVSRSGRAVAVLQLVSTVVLLLSPPPAAASRRDMSVDFHAASCPQLETIVRSAVQAALQREIALAAGLLRIFFHDCFPQGCDASVYLNATNPNTEQFPQGPNETLQPRALQLVEDIRAKVHAECGPTVSCADISALATRDAVVVSGGPSYAVPLGQQDSLAPASVDLVGDLPGPSTSRVQALIDLFATRGLGDPADLVALSGGHTVGRARCDFFRDRAGRQDDTFSKKLKLNCTKDPNRLQELDVITPDAFDNAYYIALTTGQGVFTSDMALMKNQTTASIVRQFAQDKAAFFDQFAKSMVKLSKVPRPGGNVGEIRR... | 14 |
A0A0A0K269 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAITPKLFFLLLLQLIFVSTSLSNIARANELAVGFYKNCCPGVEYIVAKTVAQYVKKQPAIAASLLRIHFHDCFVRGCDGSVLLNSGPNNQAEKDAIPNLSLRGYNVVDAVKAAVEKQCPGVVSCADILALIARDAVRMSGGPAWEVPTGRRDGTVSISREALINLPPPFANISSLKSSFQSKGLSLKDLVVLSGAHTIGVSHCTSFSNRLYNFTGKGDADPKLDKYYAAALKIKCKPNDQKKIVEMDPGSFKTFDQSYYTLVSKRRGLFQSDSALLDDPDTKAYVQFQSSTRGSTFAADFAKSMINMGNIGVLTGTDGE... | 14 |
A0A6I8RUZ0 | 2.7.10.1 | ACT_SITE 534; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MFTIGETIELSCAAEDASTTTKWFKDGIAIVPNNRTNTRQGLLKIINISYDDSGIYSCRLWHSTEILRNFTIRVTDLPSSGDDEDDDDEETEDREPPRWTQPEKMDKKLTAVPAANTIRFRCPAAGNPTPTIHWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDKGNYTCVVENKYGSIRQTYQLDVLERSSHRPILQAGLPANQTVVIGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKYGPDGDPYVTVLQPTGVYSSDKDLEVLVLRNVSFEDAGEYTCLAGNSIGYSHHTAWLTVLPAVQMILSLNTVFVPSK... | 97 |
Q7XJ02 | 1.11.1.11 | ACT_SITE 118; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297" | MAAQRLAALHAAAPSAFSSTSSASHGRPAARSSTTALLPVALPRASATLRAAPSRLLPQEAKAAGSGRSVMCMASASASAASAAVASGAAELKAAREDIRELLKTTHCHPILVRLGWHDSGTYDKNIKEWPQRGGANGSLRFDVELKHGANAGLVNALKLVQPIKDKYPNISYADLFQLASATAIEEAGGPKIPMTYGRIDVTGPEQCPPEGKLPDAGPSAPADHLRKVFYRMGLDDKEIVVLSGAHTLGRSRPERSGWGKPETKYTKNGPGAPGGQSWTAEWLKFDNSYFKEIKEKRDQDLLVLPTDAALFEDPTFKVY... | 11 |
B8E0X7 | 3.5.1.88 | ACT_SITE 130; /evidence="ECO:0000255|HAMAP-Rule:MF_00163" | MIMEIRKIGDPILKIKAKKVEKIDEKVKNLVRDMIETMKFSNGVGLAAPQVGESLRIIVVDYEENPIAFINPEILEMDGEVLDYEGCLSVPGVEVPIKRAERIIFKAQDLQGRTKRYKAKGLLARVIQHEVDHLEGILILDRAVEESTLAEEK | 183 |
Q5SIL4 | 5.6.2.2 | ACT_SITE 118; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897" | MAQVLPVEITEELKQSFINYAMSVIVDRALPDVRDGLKPVQRRILFGAYQEGVLPGRKHVKSAKIVGEVMGKYHPHGDAAIYDALVRMAQPWNLRYPLIDGQGNFGSIDGDPPAAQRYTEARLSPIGAEMLLDIDKDTVDFRPNYDGSLKEPEVLPAAIPNLLVNGASGIAVGMATSLPPHNLSEVVDALVAMIENPAITLEEVMRHLPGPDFPTGGKLSKKGIKEAYATGRGSLKVRAKVRVEEKGQRPVLVVTEIPYQVNKASLIAQIAALVKAKKIEDIVGLRDESDRQGLRIAIELKRGANPQVVLNQLYKHTALQ... | 222 |
Q94523 | 1.3.5.1 | ACT_SITE 337; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q9YHT1" | MSGIMRVPSILAKNAVASMQRAAAVGVQRSYHITHGRQQASAANPDKISKQYPVVDHAYDAIVVGAGGAGLRAAFGLVAEGFRTAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSYDCNYFVEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGYGRAFFSCTSAHTCTGDGTAMVARQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNG... | 28 |
M5WN15 | 3.4.19.9 | ACT_SITE 195; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 308; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 308; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MPSHFPTNPTSTPTPNFDDPTSSSDNPNAARSPKTTPSEMWNYLWIPFLISLSKELSLAKAQSPILLPSQLGVGPSDSPSTRCTALDPKLNYRPVIGILSHPGDGASGRLSNASTASYIAASYVKFVESAGARVIPLIYNEPPDVLFQKLNLVNGVLFTGGWAKSGLYYDIVERIFQKIIEKNDAGDHFPLYATCLGFELLTMIISKNKKILESFSAENMASTLLFTENTIIEGTVFQRFPPDLLKKLSTDCIVMQNHHYGISPERLQENPNLSSFFKILTTSTDKDNKVYVSTVHAYSYPVTAFQWHPEKNAFEWGSPM... | 176 |
A0A7M7HLU8 | 2.7.11.1 | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MSQTPSAEISRKNPLEDFELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQEILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGGGSLQDIYHMTGHLAELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVERKGGYDFQCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYFQDNIDRLTEQTMRQLLEKARNVNPGYSPIEDDDDDRLDEQALVNV... | 99 |
C3XQG2 | 2.3.1.48 | ACT_SITE 341; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MATAEQTGSVVRENVQEMNHSLPETVQLNLQKDLKPTEENGNDHIPEISETYSVRRSDGTWHDAEVIQTRRNEHEGGRMEFYVHYKGFNRRLDEWVDLCRIDVQSHSSRKKRAAEETLYDFADQPDRKITRNQKRRHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKVQIGKYEIDAWYFSPFPEDYGKCPRLYICEFCLKYMKYEKTYRHHMGECTFRQPPGKEIYRKGTISVYEVDGRGDKIYCQNLCLLAKLFLDHKTLYFDVEPFMFYILTEVDKQGAHLVGYFSKEKESPDGNNLACIMTVPPFQRKGYG... | 61 |
A0A1Y1I6F6 | 2.3.1.48 | ACT_SITE 341; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MPAAPMKVEQDLPAAERANGAVVSGAAVNGAAERPLGHGGAEENGRKRGREVTLPLEVGTRVMVKWRDGKYHMVKVIERRRLSAHAPDYEYYVHYMEFNRRLDEWVQVDAMDLNTVETENDDNKDDKGATTKMTRQQKKKIDESHVEEGHEEFDAASLREHEEFTKVKNISAIELGKYEMDTWYFSPFPPEYNNVSKLYFCEFCLSFMKRKEQLSRHMRKCDLKHPPGDEIYRNRSISMFEVDGKKNKVYCQNLCYLAKLFLDHKTLYYDVDLFLFYILCECDERGCHIVGYFSKEKHSEEGYNLACILTLPSYQRKGYG... | 61 |
A0A2R6XCD7 | 3.1.3.3 | ACT_SITE 103; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 105; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MVCSGALGATGAIPCMRSQGTLSRLRSLQPNLCCHQLSSASFALTNGALFTSVADQRKAVGQQRLRVRAAGAEPELDLVKAKSNIMDPGVLDLWRNAEAVCFDVDSTVCEDEGIDELAAFCGAGEAVAAWTARAMGGSVPFEVALAARLDLFKPSASDVAKLLASKPPRLSTGIKDLVNKLHSKGTHVYLVSGGFRQMIEPAAELLNISKDRIYANNLLFGENGEFTGFDATEPTSRSGGKAKVIEKIKAEFGYTKLIMIGDGATDLEARRPGGADMFICYGGVAVRPKVVEGSDVFVTTFTDLINTL | 147 |
A0A078HCZ8 | 3.1.1.11 | ACT_SITE 448; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKTLHFSSSLLFLSVLFLSCAFLISPQSPSPSPSELPSQPPSLPPSQSPSLPPSQPPSLPPSKPPSLPPSQSTSDACKSTPYPKLCRTILSAVKSSPSDPYSYGKFTIKQCLKQASRLSKVINGYVRRVRNKPGSMTAEEIGAVADCGELAELSVSYLETVAAELKMADMMTAALVEHVNSLLSGVVTNQQTCLDGLVEAKSGFAAAIGSPMGNLTRLYSVSLGLVSHALNRNLKRFKASKGKILGGRNSTYREPLETLIKVLRKTCDNDKDCRKAARKLGELGVTSGGSILVSQAVIVGPYKSDNFTTITDAIAAAPNN... | 125 |
Q81ID8 | 3.1.3.48 | ACT_SITE 8; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 14; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 123; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1" | MVQVLFVCLGNICRSPMAEAIFRNLVVKEGLEEKIVIDSAGTGDWHVGHPPHKGTQKILKENAVTFEGIKARQVEKEDLTKFDYIIAMDNKNIANLKSLGKTGGYIGRLSDFVPDGGWTDVPDPYYTGNFQEVYDLVTEGCAKLLAFIRNEQGI | 149 |
Q9VH90 | 3.4.19.12 | ACT_SITE 518; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 658; /note="Proton acceptor"; /evidence="ECO:0000250" | MCDTKDDAQKWKCETCTYENYPSSLKCTMCQASKPLLNEDIFRLSPAQESCTVAEEAAAVEVAVMSPTPSSTCYSLQPQSQARQSNVADSEKWPCKVCTYLNWPRSLRCVQCCTKRGGEAIERGKKDMDNEADGDRAGEALQALRISGSEENLANKPVQLIGATASHRLSLSRGIDDATHLNNLANASHNQSQSQHRQPVLQQQMQLQLQPQQQRESSSSAAVPPQQQKQCYVSKWACNSCTYENWPRSIKCSMCGKTREREISGSQNDLHASSSLNSQEENQQQLQQPNVDTVSVNNSFNKKHIYQLGSSETINNCDTL... | 175 |
A1L2G3 | 3.4.19.12 | ACT_SITE 91; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393"; ACT_SITE 169; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393" | MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQSPVYGFIFLFKWIEERRSRRKVSTLVDETSVIDDDIVNDMFFAHQLIPNSCATHALLSVLLNCSGVELGMTLSRMKAFTKGFNPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVSYVPIKDRLFELDGLKAYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYESKLDILKRNRQIILEGLQQIREKKVIRMTQQESGQDRKQQDSSSSEDTPPVVKKEEVQETPIPSGAEQATPTEAQEGA... | 175 |
O13889 | 2.7.11.1 | ACT_SITE 491; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLGTSTKCSKRDCNYAKENISRIMPTIGLGYKQNFEKKTADTQSSCKLLLVALLESFCKHSDQTPEQSKQMFLYVAHSLQNSGIIDFEFSEELEPIRNAYADSLHNLLSKAFRSTLPMSSTKDSKKSRYSSPDGVLAKTASFLSVLSDGGYEDDVMNVKPSVNVLSNRLNHLPVEALESCFPQTTLESSTFADFCEHKDGTGNLSFSNFDSFPTVQRSRYASDFEELELLGKGGYGSVYKARNKFDGVEYALKKIPLRLRSFSTSSNIFRESRTLARLNHPNVIRFFSSWVELLPSSEKQIEEEPLASADETLSQSADID... | 99 |
A0BDW1 | 2.7.7.7 | ACT_SITE 342; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MFPLSTVNLTNNRIKTLRNLIERNGGTIELNSRTIMIVGSDATSESCQKQLEKMHLNFEQYRQQFINADWISQSLQAKNLLDFKKYQLFSEIEQKQKRVSPQSTDTKFVYIESLAKTVPLKEDAEDSLDMESGEYTIIKPEMREKYEKKKQEFKRQMIKENRFLLDYEYDKDLDNYHHQVDDGYEFLLDNFQILKKEEFDAPQQNKFYGDEDCQITEIRKPSIDIFQGLDMGKALVNVDQPLVNAQIKETKQFQPGSKQQIQYWENKREFFICDAGSAQKCYNNQIIEELEKLLKIYTNEKDKGRCIAYRKAIGYIKSLT... | 121 |
W1NKJ6 | 3.1.1.11 | ACT_SITE 76; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLPFFAITAVAGDGFLARDITFENTAGPEKHQAVALRVNADVSAFYRCSFRGYQDTLYVHSLRQFYRECDIYGTVDFIFGNAATVFQACNIFLRKPMKGQFNVITAQSRDDPNENTGISIQNCTIEADTDYEGSQGSTKNYLGRPWRIYSQTVYMESYIGGLIDLAGWTNWSGNRGIDTLYYGEYNNDGPGSATDNRVSWPGYHVMDYSDAKDFTVSEFIDGNEWLDSTSFPYDDGV | 125 |
A0A078J291 | 3.1.1.11 | ACT_SITE 251; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKFRTISLPLSIGIAIVAILASKTLFDTHPRAFMHNPFDVLHTIKAISYSAITSVYSRHHHHHHHHHKKPSDTKKKVSICDDFPKNIPPPDTDTTSYLCVDKKGCCNFTTVQSAVDAIGNFSQKRNVIWINSGMYYEKVVIPKTKPNITLQGQGFETTAIAWNDTAYSANGTFYCATVQVFGSQFVAKNISFMNVAPIPKPGDVGAQAVAIRIGGDQSAFLGCGFFGAQDTLHDDRGRHYFKNCYIQGSIDFIFGNAKSLYQDCQIISMANQVSPGSKSVNGAVTANGRNSKDENSGFAFVNCTIGGTGHVWLGRAWRPY... | 125 |
Q7QJ74 | 2.7.11.1 | ACT_SITE 194; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000605-50" | MAGVFDLELHEEEDLRDSDDDIIDIEDVDLEPELHINTNLETEGSETIPLSEDIINPGRIKLGPQDFELKKVLGKGGYGKVFQVRKTTGADANSYFAMKVLKKASIVRNQKDTAHTRAERNILEAVRHPFIVELVYAFQTGGKLYLILEYLSGGELFMHLEREGIFLEDTACFYLCEIILALEHLHNLGIIYRDLKPENVLLDAKGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGMPPFCADNRKKTVDAILKDKLNIPGYLTPDSRDLIRRLMKRQVSQRLGSGPTDGQ... | 99 |
P00929 | 4.2.1.20 | ACT_SITE 49; /note="Proton acceptor"; ACT_SITE 60; /note="Proton acceptor" | MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTLIDAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQCFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQVGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADDDLLRQVASYGRGYTYLLSRSGVTGAENRGALPLHHLIEKLKEYHAAPALQGFGISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLASPKQMLAELRSFVSAMKAASRA | 202 |
Q8BZ25 | 2.7.11.1 | ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVPHRARRLLNPMAVGPLAQQLGSLTVFTRDDFEEEWHLVASGGFSKVFQARHKRWRTQYAIKCSPCLQKETTSSEVTCLFEEAVKMEKIKFQHIVSIYGVCKQPLGIVMEFMASGSLEKTLPTHSLCWPLKLRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPEYDVYSFAIVIWEILTQKKPYAGLNMMTIIIRVAAGMRPSLQDVSDEWPEEVHQMVNLMKRCWDQDPKKRPCFLNVAVETDMLLSLFQSPMTDPGCEALTQKV... | 99 |
F4K6B8 | 2.7.11.1 | ACT_SITE 882; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MPRNPRFCFFLFLLFHSSLFFSIPCFSIDEQGLALLSWKSQLNISGDALSSWKASESNPCQWVGIKCNERGQVSEIQLQVMDFQGPLPATNLRQIKSLTLLSLTSVNLTGSIPKELGDLSELEVLDLADNSLSGEIPVDIFKLKKLKILSLNTNNLEGVIPSELGNLVNLIELTLFDNKLAGEIPRTIGELKNLEIFRAGGNKNLRGELPWEIGNCESLVTLGLAETSLSGRLPASIGNLKKVQTIALYTSLLSGPIPDEIGNCTELQNLYLYQNSISGSIPVSMGRLKKLQSLLLWQNNLVGKIPTELGTCPELFLVDL... | 99 |
C4LY84 | 3.2.1.143 | ACT_SITE 229; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 247; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 248; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MENKIIQTSTLSIEKIRTAITKEFKTCQDVVEFFINQEEERTNKKINKGVGDGYEIALKSFYNKVHSLGVTKKSFEEYFQWFIGGLKNAMNKLINNNDGNLEKNQSTIYIPISKSGTPSTIQIKRWEIFGILACSFFNVQWDKKVERIGNLSFVYISTNSRISIQRLICIFAYFHVMIEMDEKTLQEIVTYERVIQKKPYDWEHNETPIKTYPFVSGGLEMSEMNVHVDFANKYLQIHKIVPSITQEELLFSVRPECLISLILFEVLLDNEAVLIKNTLHISLSEGYQQTFKWIGFCKNQILKQPNIILAIDSVINSCFG... | 159 |
A0A9J7NAQ0 | 3.5.4.5 | ACT_SITE 68; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MAEKSAASAGLTDEQIHELVQKSHQAKQRAYAPYSNFRVGAALHTEDGTIFTGCNVENASYPLCCCAERTAIFNAVTEGCRTFRAMAVATDVESEFLAPCGSCRQVMREFGTDWTVYLTKPDLSYRTMTVGELLPCSFGPDDLNKPKVKGQ | 187 |
Q39238 | 2.7.11.1 | ACT_SITE 539; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSDDMVLHFSSNSSNQSDHSLPDKIAKLEARLTGKTPSSAKPPQQQQQQQQQVSLWSSASAAVKVVTSTPPGLSETSISDSDDENTGDFLIRANTKKRQKVQESNNFSVVDHVEPQEAAYDGRKNDAESKTGLDVSKKKQGRGRASSTGRGRGSKTNNDVTKSQFVVAPVSAASQLDASDQKDFRPDGQLRNGECSLQDEDLKSLRAKIAMLEEELRKSRQDSSEYHHLVRNLENEVKDLKDQEQQGKQKTTKVISDLLISVSKTERQEARTKVRNESLRLGSVGVLRTGTIIAETWEDGQMLKDLNAQLRQLLETKEAI... | 99 |
H3GS17 | 3.1.1.11 | ACT_SITE 205; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MHTFALPLLALASLATSTLAAIDCTSNGANARTQPPSGAVVVDASGAYKGSYQTVSEGVANIPNTTAEHTLFVFPGVYHEQVIVPKFNGPLVLQGYTCDTKSYADNQVTVTHTMAQRDLPANTTGALNALVSTMLFKSRNGVKVYNLNIANPTGKIKQLGQAVATYVDNTDYGFYACNFTGYQDTLCANKGKELYARSYIAGAVDFVFGLQSKAWFESCDIESVGKGSITANGNGNSSNLSEYVFNNARVFGALGNGTAYLGRPWYPYARVVWQNSNLSDVINPQGWQTWNKDNNTGNVYFKEFNNVGAGAATDERVAFG... | 125 |
P54350 | 2.7.10.2 | ACT_SITE 361; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MAFRQSEHEMSVTSLDSSVELRSRSPSPQVFNPRKLRFADDDFDKDTPEGASPQHPLQQRPKLSSGEEQQLDSKIGKEGGDGDVSMSPPCQKVRALRLFSTPATPKTILQKSTTQCSNHLSAAAAAVNASRRSDDLFRLSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDACDDDVTEEAGDSMREIHQQAPKRLALHDTNISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHMLIQNEFCD... | 98 |
A0A804HY81 | 3.1.1.11 | ACT_SITE 388; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGNNKVAVLSISAIVLVAVVATVAVTVSNRRSQSADPQLSTSVKNVQDFCRPTDYKETCENTLSSVAGPDADPKELLNLAFNITVKHINDAIDHSTVLSEAAKDPSTSEALENCRELLDYAIDDLRRSVDRLGDFSVANLDKFLDDLKIWLSATITYQETCVDGFEGTTTNAGESMRKMLNSSSELTSNILAIVNNFDDTLSSLNLPINRKLLAEGYPSYVTPGKRRLLATSTADLKPNVVVAQDGSGDVKTIGEAISRVPNKGADIFIIHIKEGEYKEKVHVNKSATNVMLIGDGPTKTKITGSLNYVDGTRTFDTATV... | 125 |
Q6ZLF6 | 3.1.1.11 | ACT_SITE 383; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASMCSRSIPQLILLLSLTVFLLANAHPMAPPSPPRKAAAPPTAAKGVTGISPVLVSTLRETLDAIKNVASIISSFPIGGILGGGDLRLSSAIADCLDLLDLSSDELSWSMSTTSSSSYQPTNAGAATSSHVGTGDARSDLRSWLGGALSNQDTCKEGLDDTGSVLGSLVGTALQTVTSLLTDGLGQVAAGEASIAWSSSRRGLAEGGGAPHWLGARERRLLQMPLGPGGMPVDAVVAKDGSGNYTTVSAAVDAAPTESASRYVIYVKKGVYKETVDIKKKKWNLMLVGDGMGVTVISGHRNYVDGYTTFRSATVAVNGK... | 125 |
P41415 | 2.7.11.1 | ACT_SITE 137; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MATTNATLQTLVQFYENCKNVKTRYKIINGRFGKISILSHKPTSKLYLQKTISAHNFNADEIKVHQLMSDHPNFIKIYFNHGSINNQVIVMDYIDCPDLFETLQIKGELSYQLVSNIIRQLCEALNDLHKHNFIHNDIKLENVLYFEALDRVYVCDYGLCKHENSLSVHDGTLEYFSPEKIRHTTMHVSFDWYAVGVLTYKLLTGGRHPFEKSEDEMLDLNSMKRRQQYNDIGVLKHVRNVNARDFVYCLTRYNIDCRLTNYKQIIKHEFLS | 99 |
A0A0K9Q1K1 | 1.11.1.7 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MANYNSLRTKLTTMLKLVVVLSLSLLAAGVNGELNVGFYQNTCPNAESLIQQAVSDAFANNSGVAPGLLRMHFHDCFVRGCDGSVLLDGNDTEKTSIPNLSLRSVAFDLIDDAKTAVEKECPGIVSCADILAFAARDSANLTGGVTWDVPAGRRDGNMSIASEALTNLPPPSFNATQLVDRFKEKNLTAEEMVLLSGAHTLGRSHCVSFTKRLYQNTSIPDSAAQTDPTLSLAYADLLRNLCPSNSNATDTVTTLMDLITPNTLDNKYYLGVMNNLGLFKSDQALMTQDDLLAFVQEFNANATEWATKFGAAMVQMGRFD... | 14 |
Q8ZYG2 | 3.5.4.5 | ACT_SITE 53; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MEDLVKIATNIIDRAYAPYSKFKVASIVKTKSGKIYTGVNIENASYGLTICAERVAVFKAVSEGDRDIDTVIIYTDTDEPTPPCGACRQVIAEFNPNALIVMASRKKVITQRLSELLPNVFSLKPSQ | 187 |
H2LQD3 | 2.7.10.2 | ACT_SITE 952; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1" | MPLNKREEDSTPLVIRDRGGSQTSSSSVTPGLQVHLYYFPDTKAGTTIHISSKQISAENVCIKAGEICGILPVYIDLFGLTSADMSFWYPPSHMFDSDENLEVHFRVRFFFRNWLGQGSRASCRYSLTRDRISPVLDYNVIDYLFAQMRSDFISSRCGVEPPLSVQEECLGLAVLDLWRMAKERHQSIRELCKTVSYKSCLPKSHRHDIQKRNRLDRYRIRNTLKRFLKKLGNCSVDECSLKIKYLMELAGIEPSMGSETFHVSHFSSQSKAPFKLVRVTGDTGIQTSGDDDSDGPPKWETFCDFGEIIDISIKRVCQDQ... | 98 |
P29340 | 2.3.2.23 | ACT_SITE 115; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MPNFWILENRRSYTSDTCMSRIVKEYKVILKTLASDDPIANPYRGIIESLNPIDETDLSKWEAIISGPSDTPYENHQFRILIEVPSSYPMNPPKISFMQNNILHCNVKSATGEICLNILKPEEWTPVWDLLHCVHAVWRLLREPVCDSPLDVDIGNIIRCGDMSAYQGIVKYFLAERERINNH | 64 |
Q59Q46 | 1.1.1.205 | ACT_SITE 333; /note="Thioimidate intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_03156"; ACT_SITE 435; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03156" | MVFETSKATSYLKDYPKKDGLSVKELIDSTNFGGLTYNDFLILPGLINFPSSAVSLETKLTKKITLKSPFVSSPMDTVTEENMAIHMALLGGIGIIHHNCTSEEQAEMVRKVKKYENGFINDPVVISPEVTVGEVKKMGEVLGFTSFPVTENGKVGGKLVGIITSRDIQFHEDNKSPVSEVMTKDLVVGKKGISLTDGNELLRSSKKGKLPIVDAEGNLVSLISRTDLQKNQDYPNASKSFHSKQLLCGAAIGTIDADRERLDKLVEAGLDVVVLDSSNGSSVFQLNMIKWIKEKYPELQVIAGNVVTREQAALLIEAGA... | 3 |
W5MYR2 | 3.2.1.52 | ACT_SITE 340; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MAALVKFVFLLFGATACLGWQNNLADVPKLTVSAYGSLWPLPQSVHISPVAFRVSSFGFQIVHSPKSSAGPSCFLLQNAFRRYFEYTFGYSKKLKGDLKMVANDSEVFELQVWISSENPECDSYPSVKSDESYELSIDQPTAVLKAPKVWGALRGLETFSQLVYADKYGTNYINKTDIQDFPRFAHRGILLDSSRHYLPLKVILANLDAMAMNKYNVFHWHIVDDHSFPYQSTAFPNLSTEGSYHPYTHVYTPTDVKMVIEYARMRGIRVVAEFDTPGHTQSWGLGQKGLLTPCYAGDTPTGTFGPVNPILNSTYEFMTQ... | 170 |
Q6AVZ3 | 1.11.1.7 | ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAVSSPAPSSLHVPMAAAALLGMLMMMSSAPEMKVEAAGGLSVGFYAESCPKAEAIVRDTVTKAFEKAPGTPADLIRLFFHDCFVRGCDASVLLESTPGNKAERDNKANNPSLDGFDVVDDAKDLLEKECPHTVSCADILSLVARDSAYLAGGLDFEIPTGRRDGFVSKEDEVLSNVPHPEFGAKDLLKNFTAKGFTAEEMVTLSGAHSIGTSHCSSFTNRLYKYYGTYGTDPSMPAAYAADMKSKCPPETAAQQDATMVQLDDVTPFKMDNQYYRNVLAGNVTFASDVALLDTPETAALVRLYAAGDPAAWLARFAAAL... | 14 |
Q9I4W5 | 1.11.1.24 | ACT_SITE 45; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MPVAIDKPVPDFTAPATSGKEVTLSALKGKQVVLYFYPKDSTPGCTTEGQGFRDQYAAFQKANTEVFGISRDGLKSHENFKCKQEFPFELISDKDEAVCQLFDVIKLKKLYGKEYMGVDRSTFLIDRDGVLRQEWRGVKVPGHVDAVLAAAQALNGA | 12 |
A0A9R1X0R4 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAYKKHISSLLLQLILLAFVFVSANGSYLKLGFYQKTCPNVEAIVAKVTADHISVAPSLAAPLLRMHFHDCFIRGCDGSVLLDSTKTNAAEKVGPPNLSLRGYQVIDAAKSALEKECPGVVSCADILSLVARDAVYQIKGPWWPVPLGRRDGRVSIALESLSLPAPFGNIAQLKAQFASKGLSVKDLVVLSGGHTIGTSQCSTIVIRLYNFTGKGDTDPTLDPKYVPFLKKKCKPTDTTTLLEMDPGSFRTFDEDYYTIVMKRRGLFQSDAALLDDKETSAYVKFQAQSHGSTFFKDFEESMVKMGQIEVLTGSAGEIRK... | 14 |
A0A804KEY6 | 1.1.1.8 | ACT_SITE 232; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MAPSIEGKRPEVKSPMNTTCCNREEITPRYRVTVVGSGNWGSVAAKLIASNTVKLPIFHDEVRMWVFEEILPGGEKLSKAINQTNENVKYLPGIKLGKNVIADPDLENAVKEANMLVFVTPHQFVAGICKRLVGKIKPNTEAISLIKGMEVKTEGPCMISKLITDMLGINCCVLMGANIANEIAVEKFSEATIGYKQDKEVAQRWARLFCTPYFLVSVVQDVEGVELCGTLKNVVAIAAGLVDGMNMGNNTKAAIMRIGLREMRALSKLLFPSVRDSTFFESCGVADLITTCLGGRNRKVAEAFAKSGGKRSFDELEAEL... | 7 |
A0A1U8AT85 | 4.1.1.17 | ACT_SITE 369; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MAYEQLRAMGSSHKSLQAVLAAPGVKVKKVTSLSADGLTDFIQSMISKKQEMKDPFYVLDFGVVVSLMDKWKRSLPNVRPFYAVKCNPHPAFLAALAALGVSFDCASRAEIEAVLALGVSADRIIYANPCKAEAQIKYAASVGVNLTTFDSREEIDKLRRWHPKCSLLLRLKAPDDGGARCPLGPKYGALPEEVTPLLQAAHVARLTVAGVSFHVGSGATHSRAYSGAIAAAKAVFDTAVGLGMPRMSILNVGGGFTAGVGPQFEDAAATINAAIKVHFLDESGLTVIAEPGRFFAETAFTLATNIIGKRVRGKLREYWI... | 195 |
Q4X262 | 2.7.11.1 | ACT_SITE 243; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MATKALEARFEHLSVKDDADHGRNGSTYSKHKGSLSTAVSLSGLGAAGQFNSGSSRSTLLKLALQNTNENKVNAMHTGSSPLKGAQSTLAHRDTDENGESRHTTPLYEQPGPKKLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFHDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLKPNPQDNYYSEKVDLWSLGVLTYEFLVGEAPF... | 99 |
Q9Y7R8 | 1.1.1.37 | ACT_SITE 205; /note="Proton acceptor"; /evidence="ECO:0000250" | MFAKVAFKNFTPLKSIAPRSFSTTSSRAFKVAVLGAGGGIGQPLSMLLKLNDKVSELALFDIRGAPGVAADIGHINTTSNVVGYAPDDKGLEKALNGADVVIIPAGVPRKPGMTRDDLFATNASIVRDLAFAAGETCPEAKYLVVTNPVNSTVPIFKKALERVGVHQPKHLFGVTTLDSVRASRFTSQVTNGKAELLHIPVVGGHSGATIVPLLSQGGVELTGEKRDALIHRIQFGGDEVVKAKAGAGSATLSMAYAGARMASSVLRALAGESGVEECTFVESPLYKDQGIDFFASRVTLGKDGVDTIHPVGKINDYEES... | 5 |
Q4CUJ8 | 3.1.3.48 | ACT_SITE 75; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q4QEZ7"; ACT_SITE 107; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MGANGTLVECKRGESDAVVFRFLIFDAPSPSSVTAYVKLMQKYNVRHIVRACGQTYSAEAFEKQGMVVHGWSFDDGAPPTQTVIDNWLNLLEQEKNKSPPETIAVHCVAGLGRAPILVALALVEYGGMPPLDAVGYVRGRRKGAINQVQLNWLMRYKPRHQEGNEGSLSCAGCAVM | 149 |
P19406 | 3.1.3.1 | ACT_SITE 108; /note="Phosphoserine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10042" | MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQDKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPDYNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHATPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQAGYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKGFFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDK... | 141 |
F6PYU7 | 2.7.1.11 | ACT_SITE 166; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | RKLRKSVSSPLIGSGRCIAVFTSGGDSQGMNAAVRAIVRMGITCGAKVYLIHEGYQGMVDGGENIVEAAWDDVSGILQMGGTVIGSARCKDFREREGRLKAAFNLVTLGITNICAIGGDGSLTGANLFREEWSSLLQELVETGKINQEQATIHSHLNIVGLVGSIDNDFCGTDMTIGADSALHRIVECVDAITTTAVSHQRAFVLEVMGRHCGYLALVTGLACGADWIFIPEHPPADGWEEKMCGKLNNARSWGNRLNVVIVSEGAIDCHGNAITSQQVKEVICKRLDLDTRITVLGHVQRGGSPSAFDRLLGTRMGAEA... | 84 |
Q8I2Z8 | 2.7.1.11 | ACT_SITE 313; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03185" | MDTKSGDKNAANKGGADGLVKTVSVLLRDNKCQFNIDENYDHNDKEKLECEVGKRDSGMINCLMEKLTSKKFLEEKESKNSFYLVDNENMKIKKLKEHGHSASLNDDLSPLQYERTKYIPSLPKALASEYQILDENYGDEFINKNDYEDVKRFLKNLHNLPMLNVKDSNNNESFKGGNILKIGIILSGGPAPGGHNVISGIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTITDSMMNRFRNLGGFNMLWSGRGKVKNKDDLIAIENIVAKLKLNGLVIIGGDGSNSNAALMAEYFAERQIPISIIGVPKTIDGDLKSEA... | 84 |
B9GPE1 | 3.1.1.11 | ACT_SITE 228; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSSASTATIFLLLAIAATTTFCHQELEKSENFRTQTDQASEALAFNVKSGKGLKRRKPNGKLLTSWNPANSKADYVVAQDGSGTHKTINDALAALDKTGGNRRNQRVIVYVKAGVYNEKVVIKKNMEKLMFVGDGIDRTIVTGNRNAKRDGYATHETATFGVHADGFWARDMTFENTAGPDGRQAVALMVSSEQSVVYRCSFKGYQNTLYVRSKRQFYRDCHIYGTIDFIFGNAAVVLQNCDIFVRKPNENQKNVIVAQGRKGPDENTGISIQGSRIRPAPDFIGVKNIPTFLGRPWRKYSRTVIFETDIDGFIDPAGWL... | 125 |
A0A022Q2I2 | 3.2.1.23 | ACT_SITE 199; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 282; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MAGNRTAAVIFVIVIVFAAFAPLPSSSHRSSSQFRLDKGGEEKFEIADDMFWKDGEPFRIIGGDLHYFRVHPEYWEDRLLRAKALGLNTIQTYVPWNLHEPSQGHVVFEGFADLVSFLKLCKKLDLLVMLRVGPYICGEWDLGGFPGWLLAKEPPIRLRSSDPVFLNLVEKWWSILLPKVFPLLYSNGGPIIMVQVENEFGSYGDDKAYLHYLVKLARTHLGDDIILYTTDGGARDTLEKGTLKGDDVFSAVDFTTGDDPWPIFNLQKEFNAPGKSPPISTEFYTGWLTHWGENIASTDASFTATYLEKILSKNGSAVLY... | 163 |
A0A9R0IZZ0 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSIKMNIHSSVRFLVLFSVLSCLSVQLEAQLQVGFYCESCPSAERIVREEVMKGFMNDKGVAPGLVRMHFHDCFVRGCDGSVLIDSTSSNTAEKDSPANNPSLRGFEVIDSAKTRLEAECKGVVSCADILAFAARDSVAMTRGQRYDVPSGRRDGRVSLVSEVFQNIPGFTFNVTRLTQSFANKNLTQEEMVTLSGAHTIGRSHCTSVSNRLYNFSGTNGADPTLDSKYAGQLQQQCPQGSTNSNQVVPMDPVSPFITDVNYYQDVLANKGLFTSDQTLLTDSNTANEVNQNARNQFLWMRKFAAAMVNMGQIEVLTGTN... | 14 |
Q09850 | 3.2.1.39 | ACT_SITE 457; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"; ACT_SITE 533; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"; ACT_SITE 537; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352" | MDVLVPIYTGPINPVFPSRAHPSPPLGLTSNLFPIQTNKFYGNLYIGTRHNPSWSHPYSVTWLNGSSYYGLAISHIDDSQRVFGPDPESVPCQYYFNPAGLYSIIISAREFASGNLLSLDQSRHFSIQATLSATTSGSGTIILPIVAGMGFVSGYYTNLTPVFNSSILFSSITKINFSRGYKYRIQLTDGKIWFLYAFPTSSSSTFNLTLASNSQLTTSTKFTGLIQICKVPNESVNNSYPDTIYDASAGVYTTSISLSAQVSGTTGEYWFRFATAGYTNLNPLMFALPHHMQSFGSDTQAYKTGLGLASTTMGIMFAYA... | 167 |
A0A7M7PR52 | 5.1.3.3 | ACT_SITE 124; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 258; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MGSTDRMAAQGYETNAPSFGVTIGRVVNRIAKGQFALDGVHYQLEINDGSNHIHGGVINFSHRLWEGHIEETGVSFSYTSPDGENGYPGEVFVTINYQLTDDNKLLISYVAKTTKATPINLTNHSYFNLGGHDSGSVTDHIVEIDADKYTPMVIETTIPSGEISSVDDTVFDLRSPTRIGDKINEVPGLGYDHNFCVKSSEKPCVMYVKHVTHKESGRKMEVSTTKPGIQFYTANYLNDSTVGKCGAIYPKHSALCLESQFYPNAVNQPNFPSCILQPGDMYTHLTAFAFSWN | 211 |
A0A1U8AJA4 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAALKLFSSVVFFIQLAIVVFHLDPTSAQGLRVGFYKNTCPAVEDIVRKTTAHYVLPVPSLAAPLLRMHFHDCFVRGCDGSVLLNSTANNQAEKSAIPNQSLNGFGIIDAVKSAVEKACPGVVSCADILALVARDAVSLVKGPYWEVPTGRRDGRVSLASEALTNLPPPFATISDLQTRFMAKGLSVKDLVVLSGAHTIGQSHCPSFTNRLYNFTGRADSDPSLDSIYIQRLKSKCKAGDVVTSVEMDPGSYKTFDTGYYKNVAKRRGLFQSDAALLNDADTKAYVIQQSTSSSGSSFFKDFGVSMVNMGNIGVLTASAG... | 14 |
P51954 | 2.7.11.1 | ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTLSKFGPQPLPGKRPASGQGVSSFVPAQKITKPAAKYGVPLT... | 99 |
A0A072UP31 | 1.11.1.24 | ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MPGLTIGDTIPDLEVDTTQGKIKLHHFCSDSWTILFSHPGDFTPVCTTELGKMAQYASEFNKRGVMLLGMSCDDLESHKEWIKDIEAHTPGAKVNYPIISDPKREIIKQLNMVDPDEKDSNGNLPSRALHIVGPDKKIKLSFLYPAQTGRNMDEVLRVVESLQKASKYKIATPANWKPGEPVVISPDVTNDQAKDMFPQGFKTADLPSKKEYLRFTNV | 12 |
P54201 | 3.4.19.12 | ACT_SITE 328; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 797; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MELFPELKNIKVPTEKSRLWKDECCYCFDTPENGEGLFIDLIGLLAFSKKYVQLNHQKTHHHLYLNFKKVAIVNEKVKSPTIENGGEEKPPKKLAIGVEGGFNVEDEEIKYEEHYKLYIFPDDKFLELSDPIIPENVRVCCEKIKTLNSQSRKEEIVSWNAESVFPSAFAESIIQLDNNTKKIDPKGPWRCDIEGCDKVENLWLNLTDGFIGCGRKYADGTGGNGHAQEHFNQTQYPISVKLGTITKDHADVYSYPEDDMVSDPLLFQHLTHWGLNPNVMVKTEKSMAELELDQNLNFEFGKIQEKGKLLENVFGPGLTG... | 175 |
P53739 | 2.7.11.1 | ACT_SITE 621; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAGHHHEHEQERDHEQEHEHDSLQRPTTGSERTRSISFSKLLTRSWKRNASSSNNMSVSSVNLYSDPENSRESDHNNSGSEGQSSRFSKLKSMFQSGNSSKNASAHNSSQSSLEGDSASSSSKLRYVKPMTSVANASPASPPLSPTIPETDVLQTPKMVHIDQHEHEREHSNCGSPIMLSSSSFSPTVARTGTGRRRSPSTPIMPSQNSNNSSSTSAIRPNNYRHHSGSQGFSSNNPFRERAGTVRSSNPYFAYQGLPTHAMSSHDLDEGFQPYANGSGIHFLSTPTSKTNSLTNTKNLSNLSLNEIKENEEVQEFNNED... | 99 |
Q9HGI3 | 3.2.1.52 | ACT_SITE 225; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q06GJ0"; ACT_SITE 278; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q06GJ0"; ACT_SITE 349; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q06GJ0" | MAYFRLYAVLLAVASSVAAVKVNPLPAPRHISWGHSGPKPLSDVSLRTERDTDDSILTNAWNRAWETIVSLEWVPAGIEAPIPEFDEFPTSTPSASAAATRSKRANVPIQFVDVDVEDWDADLQHGVDESYTLDAKAGSDAIDITAKTVWGALHAFTTLQQLVISDGNGGLILEQPVHIKDAPLYPYRGLMVDTGRNFISVRKLHEQLDGMALSKLNVLHWHLDDTQSWPVHIDAYPEMTKDAYSARETYSHDDLRNVVAYARARGIRVIPEIDMPAHSASGWQQVDPDIVACANSWWSNDNWPLHTAVQPNPGQLDIIN... | 170 |
A0A3B3HTZ2 | 3.1.1.4 | ACT_SITE 75; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 120; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MMAFCRILLISSAVAVASVAAHSSQRTRRGLLELAGAIKCSTGRSALAYMMYGCYCGLGGQGWPRDRADWCCHRHDCCYGDAELLGCHTKTAQYHWTCEDRKAECDDLKDKCEKMLCKCDREAAKCLRKAPYIQKYALWPDFMCGSEHPMCNIY | 130 |
A7SWM6 | 2.7.11.1 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 473; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | FKKADPSQFELLKVLGQGSFGKVFLVRKVIGADAGTLYAMKVLKKATLKVRDRMRTMKERDILVDVQHPFIVRLNYAFQTEGKVYLILDFLRGGDLFTRLSKEIMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDASGHVALTDFGLSKESEHDQKTYSFCGTVEYMAPEVVNRRGHSQAADWWSYGVLMFEMLTGSLPFQGKDRKDTMNMILKAKLGMPQFLTPEAQSLLRQLFKRNPLNRLGAGDLGIEDIKKHPFFSTINWELLYKREIKPPFKPAAGRADDAFYFDPEFTSKTPQDSPAVPPSATCHQ... | 99 |
A0A0K9NM84 | 3.1.1.11 | ACT_SITE 402; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MERPTKKILLVLFCSVLLLAVVITITTTSAASRRKSKSFLTVASHAVVKQSCSSTLYPDLCFETLTSASTLLHSKSSQKDVILSSVNLTRTAVEHQYFKFSKIYGHNTSKLTEREKCAVHDCLEMIDETLYELRKVEDDLNVYPGGGVSLARQADNLETLLSATMTNQESCLDGFAHNSVCRKLRSSLEDGVMHVSKMCSNSLAMIKTMTGADIKAAGAVVDRRLSENEESGFPEWMSVGDRRLLQAKSVKANVVVAKDGSGDYKTISAAVKAAPEKSKSRYIIHIKSGKYKENIEVSKKKKNIMFIGDGRSKTIITGSR... | 125 |
A0A1S4GU30 | 3.2.1.52 | ACT_SITE 555; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MLLSHDYNSRRSSIASTQSRNIRVTVLKNMFKKIALTRSALKKAIVVVSVCALASFLLLLYWNDSSESTKPSSTMAMGIYNTHIVDGSLDGGPMSAGDSVRDSAIPVNPIERLWTYRCVNNRCVRHHFVDGVEEDFDTNNAHQQQHGGQAPAGAGSANAGSSSSSPGKRIPYLTCTMTCGPINIWPQPTGATTIGSKTSRFRLSDMHVKIVTKFEPVDKLLHDAYDVLRAEVRAAMVSHGATLEEIEGAVPAASVPAGVQQLPRAEERSLATEVNDAATVGRSAGGSETSGVGKIHFFKLVSDKRYDVDAFEVNVHVEKS... | 170 |
H3G9S9 | 3.1.1.11 | ACT_SITE 205; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MHSFALPLVALASLATSTAAAIDAPCNGPNARTQPPAGAIVVDITGTYNGSYQSVAEGMAYLPNTTEEHTVFLFPGVYQEQVIVPKLAGPLVLQGYTCDSMSYAENKVTITHTMAQRDLAPEIKNNRNALVSTMRLKSSSGVKMYNLNVANPTGKIDQLGQAIAAYVDAPNYGFYACNFTGYQDTVCAHKGPELFARSYISGAVDFIFGMRAQAWFESCDIETVGEGWITANGNVNSSNLSEYVFNRARVFGSSGNGSTYLGRPWQPYARVVWQNSELGDVVHPQGWSTWDDKTSTENVYFKEFNNSGPGAAIEQRVPFS... | 125 |
Q7XRB5 | 5.3.4.1 | ACT_SITE 61; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 64; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 407; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 410; /note="Nucleophile"; /evidence="ECO:0000250" | MAVNLVLSFALAILISSSPTAVGVDATEELKEAVLTLDAGNFSEVVAKHPFIVVKFYAPWCGHCKQLAPEYEKAASILRKNELPVVLAKVDAYNERNKELKDKYGVYSYPTIKIMKNGGSDVRGYGGPREADGIVEYLKRQVGPASLKLESAEEAAHSVVDKGVILVGVFPEFAGMEYENFMVVAEKMRADYDFFHTSDASILPRGDQSVKGPIVRLFKPFDELFVDSEDFGKDALEKFIEVSGFPMVVTYDADPTNHKFLERYYSTPSSKAMLFVSFGDDRIESFKSQIHEAARKFSGNNISFLIGDVADADRVFQYFG... | 215 |
Q5BAU6 | 4.1.2.13 | ACT_SITE 84; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001359-1" | MPLNKPNPALSILDHASKNNYAVPAMCVYNVEGILATVRAANKKRSPAMIQLFPWALHYADGLLVHAAAEAAKSAEVPVTVSMDHAQTPEIIRRAADIGGFDSIMVDMSHYEKEENLRLTRELVAYCHERGIATEAEPGRIEGGEDGVADTAELEGLLTTPEESEEFVDTGIDWLAPAFGNVHGEYGPRGIQLEYERLKSINEKVGDRVRLVLHGADPFTEEIFRKCIECGVSKVNINKVLNNEYVKVQREKAGRVPLTQLLEEATDEMQKAVEKCMDMLGSTGRY | 197 |
B5YKR8 | 4.2.1.11 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00318, ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00318, ECO:0000256|PIRSR:PIRSR001400-1" | MGEIIDIIAREVLDSRGNPTVQVDIYLDSGVMGRATVPSGASTGTREALELRDGDKKRYFGKGVQKAIDNIINEIAPNIIGMESLDQEGIDRFLIELDGTENKSKLGANAILAVSMAVCKASAEEVGLPLYRYLGGTNAKVLPVPMMNIINGGIHADNNLDIQEFMIVPAGFVKFSQALRAGVEVFHSLKGILKKKRLNTAVGDEGGFSPMLEKNEDAIKLIIDAIKEAGYEPGKDIYIALDPAASEFFAEGFYTVEGKKIDSKDMVDYYEALVDKYPIISIEDGMSEADWEGWELISQRLKNKIQIVADDLVVTNPKII... | 200 |
Q5XIJ5 | 3.1.2.22 | ACT_SITE 190; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q96GS6"; ACT_SITE 255; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:O75608"; ACT_SITE 284; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:O75608" | MNGLSVSELCCLFCCPPCPGRIAAKLAFLPPEPTYSLVPEPEPGPGGAGAAPSGPLRTSAATPGRWKIHLTERADFQYGQRELDTIEVFVTKSARANRIACMYVRCVPGARYTVLFSHGNAVDLGQMCSFYVGLGTRIGCNIFSYDYSGYGISSGRPSEKNLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRVAFPDTKKTYCFDAFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDIELYSQYLERLRRFISQELPSQRT | 134 |
A0A3B3I282 | 3.1.4.11 | ACT_SITE 325; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 372; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MNKKRYFLDPPEVKDYLVKGERFTKWSEDSTKTVPVTMKMDPKGFYVYWMNQSKETTFLDVNTIRDTRTGKYAKLPKHPKVRNVFNLDFPDSNHLAKTLTIVSGPDMVNLTYHNFFASKDKVTQNWANDILAISYNAARNNACRQVFLEKIYVRISLQTNKDGKIPVKNIYKMFPADKKRVESALAAAHLPKGKYDSMKADVFTEAAFRTFMMNLCPRPEIYEIFTSYSTKPTMSKENFTKFLYEKQRDSRLNEELFPRLRQDQIKALIDKYEPISTNSNRGFISPEGLLFFLMGPETSVVMQDKLAKSQDMTQPLPHYF... | 153 |
Q55848 | 2.7.6.1 | ACT_SITE 214; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MSAVSRIATLTRQSMLSALSDNNRLRLFSGSSNPSLSQEVARYLGMDIGPMLRKRFADGELYIQIQESIRGGDVYLIQPCCHPVNDNLMELLIMIDACRRASARQITAVLPYYGYARADRKTAGRESISAKLVANLITGAGAQRVLAMDLHSAQIQGYFDIPCDHMYGSPVIIDYLKSKQLTDLVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQSHNVAEVLNLIGDVDGKTAVLVDDMIDTAGTLSEGSRLLRAQGARQVYACATHAVFSEPAINRLSGGLFEEVIVTNTIPVPDDHHFPQLTILSVANLIGEAIW... | 114 |
W1NKE2 | 3.1.1.11 | ACT_SITE 413; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAEKLQWRRDRTLSLLFSTLLFFSLLTLTQATPPSPLEATTPNPPTPLSPNGSSPPLNPVTACKTSLYPKLCRSLLSPLKSSSLKDYGRFSIKRCMKETQKTAKVIDRFLTRRSSLRHVEAGALEDCRLLSDLNADYLTQIAGDLWSSDSISDTRVGRVNSLLSAIVTNQHTCYEGLEASSSRLQQLLGASLANGTKLYSISLDLVANAWKQKGRFPGQKPAIFPARDSFPIHKPAGFPAEKGFAAEKLRFPAKGLGMRDFVTVSKGKDGNFTSINEAVASAPNNTNVEEGYFVIYVKEGVYEEHVTVARNKKNLMVIGD... | 125 |
Q10SI9 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEARGSRGMRLWLLSVAVMAMAMATRSQAQLQVGYYDTLCPAAEIIVQEEVSKAVSGNPGMAAGLVRLHFHDCFVRGCDASVLLDSTQGNRAEKDAPPNTSLRGFEVIDSAKSRLETACFGVVSCADVLAFAARDALALVGGNAYQVPGGRRDGNVSVAQETNGNLPPPSANVAQLNQMFGAKGLTQAEMVALSGAHTIGVSHCSSFSNRLYSSGPNAGQDPSMDPSYVAALTTQCPQQQGQPAAGMVPMDAVTPNAFDTNYYAAIVANRGLLSSDQALLADQTTAAQVVGYTNNPDSFQTDFAAAMVKMGSIGVLTGNA... | 14 |
F1MRH9 | 3.1.3.48 | ACT_SITE 1065; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000934-1" | MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREITYFSLWYYNKQNQRRWVDLEKPLKKQLDKHALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGNIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALLPVEWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGVFVKHKSGRPPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYVWRLCVARHKFYRLNQCSLQTQTVIVNP... | 149 |
Q8Y417 | 2.2.1.1 | ACT_SITE 410; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MKKTLDRQAVDTIRSLSIDMIEKANSGHPGMPMGAAPMAYMLFAKHLVFNPANPEWFNRDRFVLSAGHGSALLYSMLHLFGYDVKMEDLKQFRQLDSLTPGHPEFGWTAGVDATSGPLGQGIGMAAGMALAESHLAAEYNQPNYPIVDHYTYAICGDGDLMEGVASETASLAGHLGLGKLIVLYDSNDICLDGDLSATFSENAADRFRAYGWQVLRVEDGNNLAAIQEKIVQAKLETSKPTLIEVKTVIGYGAPTKAGSSASHGAPLGEKEANGAKEHYEWAEEPFTVPAEVRDYLRNYKARGEKLEGAWNTMLANYKKE... | 51 |
O16581 | 3.2.1.45 | ACT_SITE 254; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 358; /note="Nucleophile"; /evidence="ECO:0000250" | MSIAWSCFVLGLFALASLQVALANDCAQKTFKTGIVCVCNITYCDEIPDINLLSGQAATFTTSKSGARLHRDVVYATNSDPLTSMHFTIDSSKTYQTIQGFGSTFSDASGANLKSLPDQMADTILRQYFSDSGLNLQFGRVPIASNDFSSRVYTYDDNLEDYNMAHFSLQREDYQWKIPYMQMAQKYNHDLKFFAVPWSAPGWLKTTNSTKGYGILLGTNQDTYHKSYVTYILHFLEEYQKNGILFWGLSTQNEPTSGSDKKTKMQSMGFTAEFQRDFIKLDIGPALKSSNAGKNVKILILDDNRGNLPKWADTVLNDKD... | 168 |
Q11GB4 | 1.3.3.3 | ACT_SITE 131; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MEQPHIPAGLPEDVENKKEAARAWFETLRDKICAALEGLEDELSGPHSSYAPGRFEQTPWLRQEGAGGGGVMSIMHGRVFEKVGVHTSTVHGEFSPEFRRQIPGAEEDPRFWASGISVIAHPQNPHVPTVHMNTRMVVTTRQWFGGGADLTPMLNRRRSQEDPDAIAFHKAMRFVCERHAAVADYEKFKNWCEEYFFLPHRNEPRGIGGIFYDWLKSPEENGGWDADFAFTQDVGRAFVMVYQHIVRKNFNTNWTEADREEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVNSILSSLPPVVKWP | 27 |
Q9H3S7 | 3.1.3.48 | ACT_SITE 1392; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044" | MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTMDVIGGKYNSAKKDNDFIY... | 149 |
B6JW74 | 3.4.19.12 | ACT_SITE 306; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 717; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MTCPHFTEEYAHCPPTGTVIYQEECVRCFISTDSSSGIDLCLCCFESGCTKNDLSHNVSHFDLTKHPIYLNIRRTPKDQEEPPQKLTKLEIKEENEADKFQFYYNAHCIVCDVAIDQENEKVKAIVDALKKSPSASQMSQVKSWENEIVPCEHVLTLQQTPAYTVSVNGSCTQCELSENLWLCLNCGKLSCGRKQFGGGGGNGHAVEHFQSTNHGVAVKLHSLSASSQPDVYCYICDEERDDPEIKNHLSTFGLNLDSMSKTEKSLAEMQLAQNLNFDFGSMEEEEGAKKLFGPCLTGLRNLGNSCYLSSVVQALFSIDV... | 175 |
Q6CFS5 | 2.7.11.1 | ACT_SITE 330; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTDKWVPGQGQPMYGSQQPHNLMPPPSGLYQQNSNQSNTSLDQQQQFNQQQYNSQQQYQQQQHSQYQQQQQQHQQQQQQQQQQQQQQQQQQQQQQQQHQQHQQQQQQPQQQSVAQQQPSDYVNFTPRPDLLSKTARDRAHNTTQVISTYYKGIVQHAIERHQRRSAAEASVEQATSEERRNRVLTNYGKKETAYLRMRRTRMALEDFVTVKVIGKGAFGEVRLVQKRDNGKIYAMKTMLKKEMDMKEQWAHVKAERDVLADSDSPWIVSLYFSFQDDLYLYLIMEFLPGGDLMTMLIKYDVFSEDITRFYIAECVLAIEA... | 99 |
A0A0D1CKM8 | 2.4.1.18 | ACT_SITE 357; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 412; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MAAATTSAAAQAPAPIDYSKATDGTGVIALDPWLEPFAPALRERYGVYADWVKRINASEGGLEAFSRSYRKMGFQIDPTTQAVTYTEWAPNAVQASLVGDFNNWSRDAHPMSKDDFGKWHITIPPLAKGQCAIPHDSKIKVSFVLPSGERIERLPAWILRVTQDLNVSPVYDARFWNPAKQDRYTMRFPKPPKPDNIKVYEAHVGIATPEARVGQFKEFTKNVLPRIKELGYNTIQLMAIQEHAYYASFGYQVTNFFAASSRYGNPEDLKELIDVAHSLGITVLLDIVHSHACKNVLDGLNMFDGTDHLYFHEGGKGRHE... | 73 |
W1NJS8 | 1.11.1.7 | ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MALIVIVNLLMLSSVASLVNSLSVNYYDRTCPNAESAVTDAVKKAVLNDKTVPAALLRMHFHDCFIRGCDGSVLLESGKGNTAEKDGPPNVSLHGFYVIHNAKKAVEAICPGVVSCADILALAARDAVTLSGGPSWNVPKGRKDGRVFKATETRSLPAPTFNLSQLIQSFSQRGLSQQDLVALSGGHTLGFSHCSSFENRIHNFDASHDVDPSLNPSFASKLKNICPAHNKVKGAGSTMDSTSTAFDNSYYKLLVQGKSLFSSDQSLLSSPQTKALVAKFASSKKAFEDAFINSMIKMSSLNGGQEVRLDCRFVR | 14 |
A0A9R0K4H0 | 2.1.1.37 | ACT_SITE 511; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MATRKSARKKPSSPSSSPASASASASASASASLKSKRRKVEVKDEEIVNNGGTESTEMSLTVEGEEIADEEIVESPAGSGRKNTRKIVKKEETDCRFLGDPVSADEAKLRWPHRYPDKAEQGTKKPKTSQDDDDELILAKCHYLKAEVDGTKIFDLNDDAHVQSEEGKLPYICKIVEMFEGVDGFLYFRAQWYYRSVDTVIKESITLKETKRVFASEVMDDNPLDCLVEKLNIVRVALDLDIDSKMSAIPDCDYYYDLKYLLPYSSYIVPPPETTSPIGSESQSTISNDIEVDGAVADKKSDSAEVNQGKKAHNPETTLL... | 47 |
T1FNW6 | 4.1.1.50 | ACT_SITE 92; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 106; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 250; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIR... | MKNIEPGSHCTISVVEDPLHEGEYFFEGTEKLLEIWFSPSSPSSASGSVQGGRASLRDINRSEWELLLKNVNCEILSSRHSTTMDAYLLSESSMFVSKDRIILKTCGKTTLLEAVKPLLGLAKEQCGFDNIVDVFYSHKNYLRPDLQPETYRHFDQEVAMLDTLFEDGAAYVLGKLNKDCWYIYTLDRFNITEPDQTLEIMMMDVNQDVMNMFTQSYGLTASQLTEKTGILDILPGAIIDDWLFEPCGYSMNALLPNGRYFTIHITPEDEFSYVSFETNVPRDSYNDLITKVTDIFQPNKFIVTLMANEASPAYKLCLKM... | 196 |
P0DH86 | 2.7.11.1 | ACT_SITE 650; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MRGELPNKHHSYTFFVFLFFFLILFPDLSISVNTLSATESLTISSNKTIVSPGGVFELGFFRILGDSWYLGIWYKKISQRTYVWVANRDTPLSNPIGILKISNANLVILDNSDTHVWSTNLTGAVRSSVVAELLDNGNFVLRGSKINESDEFLWQSFDFPTDTLLPQMKLGRDHKRGLNRFVTSWKSSFDPSSGSFMFKLETLGLPEFFGFTSFLEVYRSGPWDGLRFSGILEMQQWDDIIYNFTENREEVAYTFRVTDHNSYSRLTINTVGRLEGFMWEPTQQEWNMFWFMPKDTCDLYGICGPYAYCDMSTSPTCNCI... | 99 |
A0A0R4ITP2 | 3.4.19.12 | ACT_SITE 14; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 119; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 119; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 134; /evidence="ECO:0... | MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAQQLDEEERMRMAEGGVQTEEYRTFLQQPSGNMDDSGFFSIQVISNALGVWGLEIVLFNSREYQQLQMDPMHEKAFICNYKEHWFTVRKLGQQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVIRGNLPECEADQILRIMRVEQQQRPKLIGEEEAQRMSAPHASETTHTAEEPVLDEDEEELRKALALSRQDLQVEDEEADLRRAIQMSMQGSSDAGSSAPAGGSSEKQTLSAEELRRRRQAYFDRQQNAQDSSSSTGGGTDSGPKPTQ | 175 |
D6WVS3 | 1.3.5.1 | ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MSGLLKIQTIFPKHILTNVAKNPKVLAQGLHIGVDKKNAKVSSDAVSKVYPIVDHTYDAVVVGAGGAGLRAAFGLVAEGFKTAVVTKLFPTRSHTVAAQGGINAALGNMEEDNWQWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELENYGMPFSRTSEGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGQSLRYDCNYFIEYFALDLIMEDGECRGVIALCLEDGTIHRIRAKNTVLATGGYGRAFFSCTSAHTCTGDGTAMVARAGLPSQDLEFIQFHPTGIYGAGCLITEGCRGEGGYLINSQGER... | 28 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.