Datasets:
mrlom
/
ec-active

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
A0CLA9
3.2.1.52
ACT_SITE 312; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MKFIIVIAILIVGTYQLMPMPKQFVKGSKSMKVINKCGIQFTNGNQYPEHVIELLRHYHSLMTSKNECNFEQALNFNLKNQGALKFHISLQNDEQLYWVNKTQQEAYILKIDEYLNIQIDAHNHWGLARALDTVHQLTENDRIEFLPLIIEDEPAYSFRGVMVDTARHFLPLKTLERTIDALAINKMNVMHWHITDDESFPLLLTNYSRITHTSKYSENEYYTKSDVSYLIEYASIRGVQIIPEIDSPAHVQSWGRNISDLEYIILNCGSTIKQYGQFDPTLDLTYDVVKSVFQDLSDMFSKVQFIHFGGDEAIKSCYNQRPSIKEFMDKNGIADYIELQTYYRQRQKSIWKNEIKSKQRIAYWYNKDDKLPAEDEDIIHWWGTTDELELVANRTNDFILSDYRPLYLDIGVGNAFGNTYQTYQTWKDIYKWTPKAPEGFKGKIIGGEAPLWGETNNENTHFQRLFIRSSILGDTLWNPFSKQSEKFYEFADRLGQMEDRMNKYGFPVSPFTHDYCKRHTKICFPILYEEEEPSIGQQHQFKEL
170
Q6GP31
3.1.3.48
ACT_SITE 459; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000929-1"
MTSRRWFHPNISGQEAETLLLTNGGHGSFLARPSKSNPGDFTLSVRRHNEVTHIKIQNTGDYYDLYGGETFATLAELVQYYTEQQGLLREKNGDVIELKYPLNSQDPTSERWYHGHLSGKEAEKLLLEKGKPGSFLVRESQSKPGDFVLSVLTSEEKLENGERKSRVTHVMIRFQPDGKYDVGGGERFDTLTDLLEHYKKNPMVEKSGAVVHLKQPFNATRINAASIGTRVRELNKTADNTEKAKQGFWEEFEMLQQQECKLLYPRKEGQRLENKSKNRYKNILPFDTTRVTLRDTDESIAGSDYINANYIKNTLDEVHGSQYCKVYIATQGCLQNSVCDFWAMVYQENTHVIVMTTKEVERSRKKCFRYWPDENCSKDYGCIRVESLKMRQKKNYILRELHISRLDKTESPRPIWHYQYLSWPDHGVPIEPGGVLSFLEEINAAQKYIPHSGPIVVHCSAGIGRTGTIIVIDMLVDIINRQGLDCDIDIPKTIQMVRQQRSGMVQTEAQYKFIYMAVQKYIEVRKRPLEEEQMGKLKEHEYTNIQYSAGERARTKAQAAAAPSQHRVSDDAACVYENLNIRSTHMSSTSNAGR
149
A2C524
1.3.3.3
ACT_SITE 118; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333"
MSSSQDKANLPANNSRARAKKLVLELQDEICAGLETIDGEGKFLEESWERPEGGGGRSRVLKDGKIFEQGGVNFSEVHGNELPPSIISQRPEAKGHSWFATGTSMVLHPKNPYIPTVHLNYRYFEAGPVWWFGGGADLTPFYPYLSDTRHFHSCHKNACDTIDKDLHKVFKPWCDEYFFLKHRNETRGVGGIFYDYQDGSGLLYKGQNANGKASKIAKELGEYSLNWENLFSLAKACGQAFLPSYEPIIKKRKNQSFSTKERDFQLYRRGRYAEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKPEENSREALLTDLFTKPQDWFTDKSLEKRCLTHQALD
27
T1FGH8
4.6.1.16
ACT_SITE 221; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 229; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 306; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"
MTIGKHFLKHHLHQVRKLFCKKMQPSVRLKEPRRKRARAQAAHQEPLPVSLQCSQASTFNNWKVCKGFYDGGSVLVHDLDEIEFIYINGFFGKGAHSRGPPELLAEYLEADERFLIPCKKKRNDIEDDGLPPLPFPTLPSSDVHEPLVLSLCEAFFLTYGLGCLVIYDDQKQKPMSILRTWRLFMNFDPNFVVTYAAYHYLRSKGWVVRSGVKYGSNFVLYKDGPAFYHSTYSVVVKPVLHNSNDNIIHVGNSSNNNNSNNNNNNDNNNNHMKSNNNVDGDGDDPCAISDWTSLSRLNRITEQVAKDLVICYVIQPDNNNNNNDNNNNNDNNNSNDTNNNSTDDKNDNNNSNVNFWNSPNCLKFFKIETVTIKRWISNKERNTADTN
207
Q20480
2.3.1.286
ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
MAQKFVPEAAELCENSLKKFISLIGTVDKLLVISGAGISTESGIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRNFLAWPRFGQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGENVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPTRADHMATMKLDYKISDVLKEM
58
T1EM77
3.2.2.27
ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072"
MKLTSMRTFGLVNNIGPSWFYALEAEFTKPYFEKLSKFVRDERAKYTVYPPVSQVFSWTQVTPIHEVKVVIVGQDPYHQPNQAHGLCFSVQKGVDIPPSLKNMYKELEQSCPPFRHPGHGYLMGWAEQGVLLLNSVLTVRRNEANSHKDAGWELFTDAVMNWLNFNLSGVVFMLWGSYAHKKGDKINKTRHHVIKGVHPSPLSAHRGFFGCGHFKMCNELLKKQNKPEINWNHLP
173
Q5KP44
1.1.1.205
ACT_SITE 345; /note="Thioimidate intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_03156"; ACT_SITE 458; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03156"
MADTNPNAPPRSDSLLNPADALKYLEEYPRGDGLSLQELMDSRKNGGLTYNDFLVLPGHISFPASDVSLQSRATKNIVLNTPFLSSPMDTVTEDRMAIALALHGGLGIIHHNCSAEEQAAMVRRVKKYENGFITDPLCLGPDATVGDVLEIKAKFGFCGVPITETGAPNSKLLGIVTGRDVQFQDAETPIKSVMTTEVVTGSSPITLEKANSLLRETKKGKLPIVDSNGHLVSLVARSDLLKNQNYPYASKVPESKQLYCGAAIGTRPGDKDRLKLLAEAGLDVVVLDSSQGDSVYQIEFIKWIKQTYPKIEIIAGNVVTREQAAQLIAAGADGLRIGMGSGSICITQEVMAVGRPQGTAVYAVAEFASRFGIPCIADGGIGNIGHIAKALALGASAVMMGGLLAGTTESPGEYFYHEGKRVKVYRGMGSIEAMEHTQRGSASGKRSILNLDNAATARYFSEADAVKVAQGVSGDVADKGSINKFVPYLFTGLQHSFQDAGVKSVSELHSCARSGSLRFELRTASAQLEGGVHGLNSYTKRLFA
3
B8DYL0
1.1.1.49
ACT_SITE 228; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966"
MNNKFIIVIFGGLGDLAQNKLYPVIYSLYKKYRLLNCTKIISTGRRPNVDKEEFLKILEKSIKTHDDSFFSLFDFVKFDLEKEEEYNHLKNMLSNFKEEEFIFYLATPPTTFETIIKNLGEFLKSFPNKRKIVIEKPFGYNLYSAQKLNQLIKIYFKEEEVYRIDHFLGKETVQNIFGLRFSNIIFEGIWNRNFIDHIQISALEDIGVEGRLGYYDKVGALRDMIQNHLIQILSIVAMEPPCCINEKEIRDEKIKVLKSIREIKREDVPLYAVRGQYEGYLIDENLSQSNTETYAAVKLFIENLRWDGVPFYLRTGKKLKRKETSIIIVFKKIPGLFSKILDCMPQEDIIGFKIAPENKIILSFQLRPLGGSMLSCPVSTSMEWTGPNIEAYETLFMDIIEGDQSLFIRKDEIEKSWEIVQPILDFWKDDPNIPIYPQGSWGPKEAEELIRRDGREWRYIDG
6
Q5A6B6
3.1.3.16
ACT_SITE 123; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P36873"
MTVPFKIPISDLDYCLEQLLDHKPPKILPPETIQQLCHTLKTELLQTPNIISLQSPISVVGDIHGQYHDLLEIFQIGGSPPQTNYLFLGDYVDRGYYSVETISLLLVLKLRYPERVFLIRGNHESRTITTNYGFYTEVLNKYQGSADVWTFITDLFDYLPLGATIDGKIFACHGGLSPSCQQLDQIRAVDRFREIPHDGIMADLVWSDPDVAISDFKLSPRGAGYLFGNDVIDKFCQDNNLVQMIRAHQLCNEGYTSYWKGKCLTVWSAPNYCYRCGNKASVLEILHSNYDSKDPTNGSDGEISSINGEFIGVNTSFESFGDDDDDYNDYRNRFNNSSRLHKQQGVLPGQFFNVFEASKENDEDTLQGKSVNGINFDDELSTSDDTSGSGGNNNKGDFFAAFFQERPKRQQVEYFL
144
H1AE12
3.2.1.45
ACT_SITE 258; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O85465"; ACT_SITE 492; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O85465"
MSGIQFDVSRLCAATISIQGRHFVDSHGRVLHLRGANVSAASKVPATPAPKIHDHAQASYVGRPFRLEEADEHWARLKSWGLTFVRITVTWEALEHKERGVYDEDYLAYLRALLQSMEPYGLVAYIALHQDVWSRYCGGSGAPGWTLEAAGFDLSNEGENLSLSGAAFLDGIKSGRLAGERGLWPTGYQKLAAATMNTLFWGGETFAPLLKVPGQIDGKWVSRNIQVYLQEAFLAATAKLVKAVGDLETVMGFELMNEPHPGFIGIQSIHEWDYTTDLHLGQFPSPLQSFSMGAGHPTPNVPVYTRSFPFPTRVTSHVTANPEGACAWASKECPWEKHGVWRWSEAKQEAAALQQDYFVKNRDGGKVDFYEDFYFPFVRKWEQVIGENISSTKGLKARMVEAIPNELCPEWKEESRPKNMVYAPHWYDLNTLFKKKFGFMSVNVQGLARGMFILRALYFGTAAAKANYALQIKTIVLAARLKLGPVPVIFGECGVPMDINNEEAFRTGDWKWQERSMDALISAMEGALMGFNLWTYNPANRDDIGDDWNAENFSWYSESNRTKLLKNAEKSSDGLDVGARLLNVIVRPYPIATAGNPTSLAYDANACAFTYRFRSPLRVSAAAPTPEEYTEIFLPRRVFRKESTEWTVTAGGKVHVDWERERVFVWFEDSSLTAASIKDDTRPRRIDIWVIGRKVEENWSIAQILVAVVILLLGVLVAYYAQLYEWEKDKMIFQHLREANGM
168
A0A9J7KSH8
2.7.11.1
ACT_SITE 161; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 529; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
MAQAALSDSGFVRLELKHANLTGHPEKVGRESFELLKVLGTGAYGKVFLVRKISGHHAGKLFAMKVLKKATIVQKSKTAEHTRTERQVLEAVRQCPFLVKLHYAFQTDVKLHLVMDYISGGELFTHLYQREYFTEAEVRVYAGEVVLALEHLHKLGIIYRDIKLENILLDKEGHVVLTDFGLSKEFLPGTEGRAYSFCGTIEYMAPEVVKGGHEGHNKAVDWWSLGVLIYELLTGASPFTVEGEKNSQSEISKRILKTNPPLSRSFSAEVKDLLMKLLMKDPQGRLGSGSRGAEDVKEHPFFKGINWEDLSAKRTPAPFTPIITNEMDTSNFSEEFTDMTPTDSPAAVPKTADRIFKGYSYVAPSILFGPNAITVNDVLRPPPNPDKPGTSSVRMAAAHLKDSPFFLNYDMDLQEGLLGDGSFSVCRRCRSKKTGEDYAVKIVSRRAVGVAREIQCLQQCQGHPNIVKLVDVYHDQVHSYIVLELLKGGELLDRIRKKKQFTEAEASLIMKRLVSAVNYMHQRGVVHRDLKPENLLFTSEADDAELKIVDFGFAKLKPENQPLTTPCFTLHYAAPEVLKDDGYDESCDLWSLGVILYTMLSGKVPFQPSVGRGGENHAADIMKKIKSGDFSLSGEEWNQVSQPAKCLIQGLLTVDPSRRFTMTALRNHDWLQGNKSHSSTPLMTPDVLEYSSGKMSKAVKHTWDAFFMVAREGFQLQDVDNAPLAKRRKMKKTSSTETRSSSSESSHSPQGPTPPTMFINQHVPSTSSGVPTQQVTILPSVVRPANTNSHSKAKPAPLLDSLMSNTVPALHPSMLVSSGLPPGQHGTRVEPSVQPASTGFTVVGSNPFQTQKQQVAPHPLSNQGHFQSNTQVSSQATLNKGLNPPEAKRTT
99
H2LZI2
2.7.10.2
ACT_SITE 682; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000632-1"
MGFGEDLWCPQAHTAVMGLLDSELHLMEVMKKWMGQRAKSEREFSVQLHSMTALVEKMDRPQNGQDYISQLNKSWEVLVLQTESLSQLMKMRSEDLLNGPISKLTLLIRDKQQLRKNYAEQWTLLRQELNKVTNTELERLKSSYRQAVKDVAQAKRKHQDASKDKDRDKNRERYIKASVKLHELHNEYVLSVRAAQVYHQHHYSQIQPALLSAIQNLQQEMVLILKEILQEYFDISTLLHHDVVRIHREMSNVLTVINPSKEYESFVHQNRSMGEIPACADFDCSLLEDSENLKPREIELNNLTYERIQHKLTAIEEELLELSRTLGSQQSAVEQLELELEEEQGGVKKGQRVYQFSKRHAMEECRQQVLLSQGIRAKLEVQRILLKEKLDQLGSREPPSALDMDSVSLTSTTSNENNLPSGKFLVDGIINNLSSLFRREGQPTNPKQDVNRPLDEQDWYHGAIPRLEVQELLKNDGDFLVRKSQEKQGYVLSVQWDGSCKHFLIQDTDNLYRLDGEGFPSIPLLIHHLMSSQQHITKRSDVVLKKPILKDKWALEHDDIILGPLIGRGNFGEVYRGQLRSENTFVAVKTCRENLAPEHKSKFLMEARILKQYDHPNIVKLIGVCTQKQPIYIIMELIQGGDFLTFLRNEGHSLATKVLVKMTENVAAGMEYLESKKCIHRDLAARNCLVAENNVVKISDFGMSRQRDDGVYSTEGGLRQIPVKWTAPEALNYGRYTTESDVWSFGILLWETFSLGMTPYTSMGNQQTREEVEKGYRMSAPHNCPVEISRMMSSCWQYDPKNRPCFKKLRADLSVIYKKIT
98
F4J0D2
2.7.11.1
ACT_SITE 259; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MATKLESFKVVEKLGVEKGEKGKMMSKKKNVKKDGDESESGFWFRFKFIFSCISSRSKVDSSMNATAVIAEPKKVIEKLEGHPAPTKDTGCAESGSSTPLMSGELKYSSKLRIFMFNDLKLATRNFRPESLLGEGGFGCVFKGWIEENGTAPVKPGTGLTVAVKTLNPDGLQGHKEWLAEINFLGNLVHPSLVKLVGYCMEEDQRLLVYEFMPRGSLENHLFRRTLPLPWSVRMKIALGAAKGLAFLHEEAEKPVIYRDFKTSNILLDGEYNAKLSDFGLAKDAPDEKKSHVSTRVMGTYGYAAPEYVMTGHLTTKSDVYSFGVVLLEILTGRRSVDKSRPNGEQNLVEWVRPHLLDKKRFYRLLDPRLEGHYSIKGAQKATQVAAQCLNRDSKARPKMSEVVEALKPLPNLKDFASSSSSFQTMQPVAKNGVRTQGGGFVSRNGPPMRSLSSLNLPQASPYRYARQSPKPKGKEP
99
Q7XSU7
1.11.1.7
ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MGAVSRSGRAVAVLQLVSTVVLLLSPPPAAASRRDMSVDFHAASCPQLETIVRSAVQAALQREIALAAGLLRIFFHDCFPQGCDASVYLNATNPNTEQFPQGPNETLQPRALQLVEDIRAKVHAECGPTVSCADISALATRDAVVVSGGPSYAVPLGQQDSLAPASVDLVGDLPGPSTSRVQALIDLFATRGLGDPADLVALSGGHTVGRARCDFFRDRAGRQDDTFSKKLKLNCTKDPNRLQELDVITPDAFDNAYYIALTTGQGVFTSDMALMKNQTTASIVRQFAQDKAAFFDQFAKSMVKLSKVPRPGGNVGEIRRSCFLSNSNGPRLDLVVAAATDQDPGFAASASA
14
A0A0A0K269
1.11.1.7
ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAITPKLFFLLLLQLIFVSTSLSNIARANELAVGFYKNCCPGVEYIVAKTVAQYVKKQPAIAASLLRIHFHDCFVRGCDGSVLLNSGPNNQAEKDAIPNLSLRGYNVVDAVKAAVEKQCPGVVSCADILALIARDAVRMSGGPAWEVPTGRRDGTVSISREALINLPPPFANISSLKSSFQSKGLSLKDLVVLSGAHTIGVSHCTSFSNRLYNFTGKGDADPKLDKYYAAALKIKCKPNDQKKIVEMDPGSFKTFDQSYYTLVSKRRGLFQSDSALLDDPDTKAYVQFQSSTRGSTFAADFAKSMINMGNIGVLTGTDGEIRRRCGFVN
14
A0A6I8RUZ0
2.7.10.1
ACT_SITE 534; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1"
MFTIGETIELSCAAEDASTTTKWFKDGIAIVPNNRTNTRQGLLKIINISYDDSGIYSCRLWHSTEILRNFTIRVTDLPSSGDDEDDDDEETEDREPPRWTQPEKMDKKLTAVPAANTIRFRCPAAGNPTPTIHWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDKGNYTCVVENKYGSIRQTYQLDVLERSSHRPILQAGLPANQTVVIGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKYGPDGDPYVTVLQPTGVYSSDKDLEVLVLRNVSFEDAGEYTCLAGNSIGYSHHTAWLTVLPAVQMILSLNTVFVPSKKAMSAPPVHKVSKFPLKRQVSLESNSSMNSNTPLVRITHLSSSDGTMLANVSELGLPLDPKWELLRTRLTLGKPLGEGCFGQVVMAEAIGIEKERPNKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLKARRPPGMDYSFDTCKIPAEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDIHNIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSYGVLLWETFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSVPFEQYSPACQDSHSTCSSGDDSVFAHDILPDEPCLPKHQQYNGAIRT
97
Q7XJ02
1.11.1.11
ACT_SITE 118; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297"
MAAQRLAALHAAAPSAFSSTSSASHGRPAARSSTTALLPVALPRASATLRAAPSRLLPQEAKAAGSGRSVMCMASASASAASAAVASGAAELKAAREDIRELLKTTHCHPILVRLGWHDSGTYDKNIKEWPQRGGANGSLRFDVELKHGANAGLVNALKLVQPIKDKYPNISYADLFQLASATAIEEAGGPKIPMTYGRIDVTGPEQCPPEGKLPDAGPSAPADHLRKVFYRMGLDDKEIVVLSGAHTLGRSRPERSGWGKPETKYTKNGPGAPGGQSWTAEWLKFDNSYFKEIKEKRDQDLLVLPTDAALFEDPTFKVYAEKYAEDQEAFFKDYAGAHAKLSNLGAKFNPPEGFTLDG
11
B8E0X7
3.5.1.88
ACT_SITE 130; /evidence="ECO:0000255|HAMAP-Rule:MF_00163"
MIMEIRKIGDPILKIKAKKVEKIDEKVKNLVRDMIETMKFSNGVGLAAPQVGESLRIIVVDYEENPIAFINPEILEMDGEVLDYEGCLSVPGVEVPIKRAERIIFKAQDLQGRTKRYKAKGLLARVIQHEVDHLEGILILDRAVEESTLAEEK
183
Q5SIL4
5.6.2.2
ACT_SITE 118; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897"
MAQVLPVEITEELKQSFINYAMSVIVDRALPDVRDGLKPVQRRILFGAYQEGVLPGRKHVKSAKIVGEVMGKYHPHGDAAIYDALVRMAQPWNLRYPLIDGQGNFGSIDGDPPAAQRYTEARLSPIGAEMLLDIDKDTVDFRPNYDGSLKEPEVLPAAIPNLLVNGASGIAVGMATSLPPHNLSEVVDALVAMIENPAITLEEVMRHLPGPDFPTGGKLSKKGIKEAYATGRGSLKVRAKVRVEEKGQRPVLVVTEIPYQVNKASLIAQIAALVKAKKIEDIVGLRDESDRQGLRIAIELKRGANPQVVLNQLYKHTALQTSFTVNLLAIVDGEPKVLSLLDLMRHYLDHRKEVVRRRSLFELRKAEERAHVLEGLLIALDHIDEVIALIRGSEDAPKARIALMERFGLSEAQAQAILDMRLQRLVALEREKLLEEYRGLMEEIARLKAILEDEARLLAEVKADLLRVKEKYGDARRTLITEFEETFNPEDLIEDEPMVITLTAQGFLKRLPLESYRAQGRGGKGLLAGRTKEEDEATHVFVADAHDDLLLFTNRGRVYRLKVYELPEMGRQARGVHVKSLLPLAEDEEVAALLSVRGLDQEGYLVFATERGLVKRTALKEYQNLGQAGLIAIRLQEGDRLVGVALSDPEDEAILATQEGQAIRFPLEEVRATGRDTQGVIGVRFKKPEDRVVSLVVVKPGEMVDLLSVSTRGYGKRTPLSEYPLQGRGGMGVITYAVSTKVGRLAALLKVRGGEDLLVLSRRGLAIRTPVAEIRQYSRATAGVRVMNLPEDDEVASAFVVEEEK
222
Q94523
1.3.5.1
ACT_SITE 337; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q9YHT1"
MSGIMRVPSILAKNAVASMQRAAAVGVQRSYHITHGRQQASAANPDKISKQYPVVDHAYDAIVVGAGGAGLRAAFGLVAEGFRTAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSYDCNYFVEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGYGRAFFSCTSAHTCTGDGTAMVARQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGERFMERYAPVAKDLASRDVVSRSMTIEIMEGRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMIFAGVDVTREPIPVLPTVHYNMGGVPTNYRGQVITIDKDGKDVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFGRACAKTIAELNKPGAPAPTLKENAGEASVANLDKLRHANGQITTADLRLKMQKTMQHHAAVFRDGPILQDGVNKMKEIYKQFKDIKVVDRSLIWNSDLVETLELQNLLANAQMTIVSAEARKESRGAHAREDFKVREDEYDFSKPLDGQQKKPMDQHWRKHTLSWVCNDNGDITLDYRNVIDTTLDNEVSTVPPAIRSY
28
M5WN15
3.4.19.9
ACT_SITE 195; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 308; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 308; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
MPSHFPTNPTSTPTPNFDDPTSSSDNPNAARSPKTTPSEMWNYLWIPFLISLSKELSLAKAQSPILLPSQLGVGPSDSPSTRCTALDPKLNYRPVIGILSHPGDGASGRLSNASTASYIAASYVKFVESAGARVIPLIYNEPPDVLFQKLNLVNGVLFTGGWAKSGLYYDIVERIFQKIIEKNDAGDHFPLYATCLGFELLTMIISKNKKILESFSAENMASTLLFTENTIIEGTVFQRFPPDLLKKLSTDCIVMQNHHYGISPERLQENPNLSSFFKILTTSTDKDNKVYVSTVHAYSYPVTAFQWHPEKNAFEWGSPMIPHSEDAIQVTQHVANFLVSEARKSLNRPPVRKVLDNLIYNYSPTFCGKAGNGFDEVYIFTQPSLAHL
176
A0A7M7HLU8
2.7.11.1
ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1"
MSQTPSAEISRKNPLEDFELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQEILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGGGSLQDIYHMTGHLAELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVERKGGYDFQCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYFQDNIDRLTEQTMRQLLEKARNVNPGYSPIEDDDDDRLDEQALVNVKKRVSSKRTDQKDRPASEINMDFVKKVKEVPRMPPDDDGMLGEGNYQGAHEWTPSNAETEGRKSLLASVEEELQKRGHQTNDFKGAEENTEEGKHYYDMLDAASESDTLPHSDRPPPLPPKQKSVKFSASNGTASNASTRESAPPSVPPSKPNRPQQQKMMNGRAPTTEGENTEDIDNKPPIVPPRRIRNEFLEPPPQQASNGLPPTPKVTMGACFSKVFNECPLVIHCSASWVHPETRDQYIIFGCDEGIYMFNLTQIHEGAMDQMFPRKTTWLYIINNIMMSLSGKNPSIYQHNLVALVDKNPHRFHMPSRFGEKLQRIPDKLVPRKFALSHKVPDTKGCTKCCVVRNPYNSHKYLCGALPAGVVLLQWYEPMNKFLQVKVFDCPLPPEIKVFEMLIKPDAEFPIVCVGVARGLDRSHLTFDVVNLNSTSSWFVEHPPTEKLLDVVCVSQIERDTVLVCFDSEHASAKLRGEVKVVNLNGRPRNSKKLLTELHFDFAVDKLVVLQDSVLAFHRHGMQGRSFRSNEVTQEICDKSKLFTLLGHEKLTVLKSHPLSDPTAPCNIYLLTGHANMM
99
C3XQG2
2.3.1.48
ACT_SITE 341; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MATAEQTGSVVRENVQEMNHSLPETVQLNLQKDLKPTEENGNDHIPEISETYSVRRSDGTWHDAEVIQTRRNEHEGGRMEFYVHYKGFNRRLDEWVDLCRIDVQSHSSRKKRAAEETLYDFADQPDRKITRNQKRRHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKVQIGKYEIDAWYFSPFPEDYGKCPRLYICEFCLKYMKYEKTYRHHMGECTFRQPPGKEIYRKGTISVYEVDGRGDKIYCQNLCLLAKLFLDHKTLYFDVEPFMFYILTEVDKQGAHLVGYFSKEKESPDGNNLACIMTVPPFQRKGYGKFLIAFSYELSKLEHRVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFKGTLSIKDLSQMTSITENDIISTLQSMNMVKYWKGQHVICVTAKLVEEHLKSAQYRRPPIMVDTSCLRWAAPKKKDVKISKK
61
A0A1Y1I6F6
2.3.1.48
ACT_SITE 341; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MPAAPMKVEQDLPAAERANGAVVSGAAVNGAAERPLGHGGAEENGRKRGREVTLPLEVGTRVMVKWRDGKYHMVKVIERRRLSAHAPDYEYYVHYMEFNRRLDEWVQVDAMDLNTVETENDDNKDDKGATTKMTRQQKKKIDESHVEEGHEEFDAASLREHEEFTKVKNISAIELGKYEMDTWYFSPFPPEYNNVSKLYFCEFCLSFMKRKEQLSRHMRKCDLKHPPGDEIYRNRSISMFEVDGKKNKVYCQNLCYLAKLFLDHKTLYYDVDLFLFYILCECDERGCHIVGYFSKEKHSEEGYNLACILTLPSYQRKGYGKFLIAFSYELSKKEAKVGTPERPLSDLGLVSYRGYWTRVLLDILKRHRGSISIKELSDMTAIKTEDVISTLQALELIQYRKGQHVICADPKVLDRHLKAAGRGGLTVDASKLIWTPYKEGGG
61
A0A2R6XCD7
3.1.3.3
ACT_SITE 103; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 105; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
MVCSGALGATGAIPCMRSQGTLSRLRSLQPNLCCHQLSSASFALTNGALFTSVADQRKAVGQQRLRVRAAGAEPELDLVKAKSNIMDPGVLDLWRNAEAVCFDVDSTVCEDEGIDELAAFCGAGEAVAAWTARAMGGSVPFEVALAARLDLFKPSASDVAKLLASKPPRLSTGIKDLVNKLHSKGTHVYLVSGGFRQMIEPAAELLNISKDRIYANNLLFGENGEFTGFDATEPTSRSGGKAKVIEKIKAEFGYTKLIMIGDGATDLEARRPGGADMFICYGGVAVRPKVVEGSDVFVTTFTDLINTL
147
A0A078HCZ8
3.1.1.11
ACT_SITE 448; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MKTLHFSSSLLFLSVLFLSCAFLISPQSPSPSPSELPSQPPSLPPSQSPSLPPSQPPSLPPSKPPSLPPSQSTSDACKSTPYPKLCRTILSAVKSSPSDPYSYGKFTIKQCLKQASRLSKVINGYVRRVRNKPGSMTAEEIGAVADCGELAELSVSYLETVAAELKMADMMTAALVEHVNSLLSGVVTNQQTCLDGLVEAKSGFAAAIGSPMGNLTRLYSVSLGLVSHALNRNLKRFKASKGKILGGRNSTYREPLETLIKVLRKTCDNDKDCRKAARKLGELGVTSGGSILVSQAVIVGPYKSDNFTTITDAIAAAPNNARPEDGYFVIYAREGVYEEYIVVPINKKNLLLMGDGINKTIITGNHNVVDGWTTYNCSSFAVTGERFMAVDVTFRNTAGPEKHQAVALRNNAEGSTFYRCSFEGYQDTLYVHSLRQFYRECDIYGTIDFIFGNAAAIFQNCNIYARKPMAKQKNAITAHGRTEPNQNTGISIINCTIKAAPDLAADPTSTMTFLGRPWKPYSRTVFMQSYISDIVQPVGWLEWNGTTGLDTIYYGEYDNFGPGAKTDRRVQWLGYNLLDMAQAMNFTVYNFTLGDTWLPQTDIPFYGGLVRKD
125
Q81ID8
3.1.3.48
ACT_SITE 8; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 14; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 123; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"
MVQVLFVCLGNICRSPMAEAIFRNLVVKEGLEEKIVIDSAGTGDWHVGHPPHKGTQKILKENAVTFEGIKARQVEKEDLTKFDYIIAMDNKNIANLKSLGKTGGYIGRLSDFVPDGGWTDVPDPYYTGNFQEVYDLVTEGCAKLLAFIRNEQGI
149
Q9VH90
3.4.19.12
ACT_SITE 518; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 658; /note="Proton acceptor"; /evidence="ECO:0000250"
MCDTKDDAQKWKCETCTYENYPSSLKCTMCQASKPLLNEDIFRLSPAQESCTVAEEAAAVEVAVMSPTPSSTCYSLQPQSQARQSNVADSEKWPCKVCTYLNWPRSLRCVQCCTKRGGEAIERGKKDMDNEADGDRAGEALQALRISGSEENLANKPVQLIGATASHRLSLSRGIDDATHLNNLANASHNQSQSQHRQPVLQQQMQLQLQPQQQRESSSSAAVPPQQQKQCYVSKWACNSCTYENWPRSIKCSMCGKTREREISGSQNDLHASSSLNSQEENQQQLQQPNVDTVSVNNSFNKKHIYQLGSSETINNCDTLQERQERRQRQIRRQVDWQWLNACLGVVENNYSAVEAYLSCGGNPARSLTSTEIAALNRNSAFDVGHTLIHLAIRFHREEMLPMLLDQISGSGPGIKRVPSYVAPDLAADIRRHFANTLRLRKSGLPCHYVQKHATFALPAEIEELPIPIQEQLYDELLDRDAQKQLETPPPALNWSLEITARLSSRMFVLWNRSAGDCLLDSAMQATWGVFDRDNILRRALADTLHQCGHVFFTRWKEYEMLQASMLHFTLEDSQFEEDWSTLLSLAGQPGSSLEQLHIFALAHILRRPIIVYGVKYVKSFRGEDIGYARFEGVYLPLFWDQNFCTKSPIALGYTRGHFSALVPMEPFTRIDGRRDDVEDVTYLPLMDCELKLLPIHFLTQSEVGNEESMMRQWLDVCVTDGGLLVAQQKLSKRPLLVAQMLEEWLNHYRRIAQVITAPFIRRPQITHYSSDGDSDEE
175
A1L2G3
3.4.19.12
ACT_SITE 91; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393"; ACT_SITE 169; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393"
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQSPVYGFIFLFKWIEERRSRRKVSTLVDETSVIDDDIVNDMFFAHQLIPNSCATHALLSVLLNCSGVELGMTLSRMKAFTKGFNPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVSYVPIKDRLFELDGLKAYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYESKLDILKRNRQIILEGLQQIREKKVIRMTQQESGQDRKQQDSSSSEDTPPVVKKEEVQETPIPSGAEQATPTEAQEGAASLPSPAGKVRSMAKPALPAGGAPPPAPLPAPSTNTIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRPPQPPYSDDEDDYDDEEEECSTAGVTNSRVRRKLGLRTRTMSRTAVGGVAAMEGQLALSVLAEKLKKEVQRKDALATTGSTPLNVRTEGRTGGISITSACQPSPTPSNESTDTASEIGSAFNSPLRSPARSQATTRPSSPVASHVGRVLFGEEEGLPRLDARHNRAVRDLGVLVSSTQLQLQEDGVIFALPPTEALEGLKKVGGVDKKKKEEASGPGGEEEVKEGPSVEMKAEDVKESVDVKPEKENLPTTDVENSTKPPGEKYTPKELLALLKYVEADIANYEVYLKEEVEKRKKYKIDDQRRTHNYDEFICTFISMLAQEGMLASLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
175
O13889
2.7.11.1
ACT_SITE 491; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MLGTSTKCSKRDCNYAKENISRIMPTIGLGYKQNFEKKTADTQSSCKLLLVALLESFCKHSDQTPEQSKQMFLYVAHSLQNSGIIDFEFSEELEPIRNAYADSLHNLLSKAFRSTLPMSSTKDSKKSRYSSPDGVLAKTASFLSVLSDGGYEDDVMNVKPSVNVLSNRLNHLPVEALESCFPQTTLESSTFADFCEHKDGTGNLSFSNFDSFPTVQRSRYASDFEELELLGKGGYGSVYKARNKFDGVEYALKKIPLRLRSFSTSSNIFRESRTLARLNHPNVIRFFSSWVELLPSSEKQIEEEPLASADETLSQSADIDNFMFDMDTGLLQHTYPSSVQILFQEDSVADDLTPCYSTKNSTCNLTDLFKKEADQDYAESHDCSSTTSQVDTLGKLAPTKSASEMLLMDSFLSEREEDECSNIPSFDQQPLCLYIQMALCEETLEKHINRRNKHIHGVMSKGLRNCYILLFARILEGVLYLHDAMHLVHRDLKPRNIFLSSGVHSEPCSVCLPNFSDEDNVEVSNAYEPVNQRTLCVVPKIGDFGLVLSQSDNLEEGTNSSAESSFVGTSTYAAPELFSKHMRSVMNNNSSTDIYALGILFFELLYPFNTRMERASAIANLKKGIFPHDFLDSMPEEASLIRSMLSSSNKRPTAAQLLTSNLFHDLVVNELHVYQALLEDAEKRNNNLKAELNILRVLNPNYDC
99
A0BDW1
2.7.7.7
ACT_SITE 342; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50"
MFPLSTVNLTNNRIKTLRNLIERNGGTIELNSRTIMIVGSDATSESCQKQLEKMHLNFEQYRQQFINADWISQSLQAKNLLDFKKYQLFSEIEQKQKRVSPQSTDTKFVYIESLAKTVPLKEDAEDSLDMESGEYTIIKPEMREKYEKKKQEFKRQMIKENRFLLDYEYDKDLDNYHHQVDDGYEFLLDNFQILKKEEFDAPQQNKFYGDEDCQITEIRKPSIDIFQGLDMGKALVNVDQPLVNAQIKETKQFQPGSKQQIQYWENKREFFICDAGSAQKCYNNQIIEELEKLLKIYTNEKDKGRCIAYRKAIGYIKSLTFPIRSSEDLKEMPTIGEKIKNKIIEIIQTGQLVKVQKLQGQEKNVAITQLSRVWGIGPTTAATFYFKGIKTLDDLRKNQHLLNRNQQVCLQLVEELEQRIPRDEATIIYDIVKREIDDLSGVPGLYKATACGSYRREKETCGDMDILITRCDGKNTDGFLLNLIQRLEGKLLTHHLTIPRRGEHDTESYMGIGRISNNAIHRRIDLKFYPKEQYGCAVLYFTGSDQYNRSMRLWAQKIGYSLSDHGLYPTQRGSQNKELWKGEVIACEEEIDVYRILGLQYKPPKERSV
121
W1NKJ6
3.1.1.11
ACT_SITE 76; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MLPFFAITAVAGDGFLARDITFENTAGPEKHQAVALRVNADVSAFYRCSFRGYQDTLYVHSLRQFYRECDIYGTVDFIFGNAATVFQACNIFLRKPMKGQFNVITAQSRDDPNENTGISIQNCTIEADTDYEGSQGSTKNYLGRPWRIYSQTVYMESYIGGLIDLAGWTNWSGNRGIDTLYYGEYNNDGPGSATDNRVSWPGYHVMDYSDAKDFTVSEFIDGNEWLDSTSFPYDDGV
125
A0A078J291
3.1.1.11
ACT_SITE 251; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MKFRTISLPLSIGIAIVAILASKTLFDTHPRAFMHNPFDVLHTIKAISYSAITSVYSRHHHHHHHHHKKPSDTKKKVSICDDFPKNIPPPDTDTTSYLCVDKKGCCNFTTVQSAVDAIGNFSQKRNVIWINSGMYYEKVVIPKTKPNITLQGQGFETTAIAWNDTAYSANGTFYCATVQVFGSQFVAKNISFMNVAPIPKPGDVGAQAVAIRIGGDQSAFLGCGFFGAQDTLHDDRGRHYFKNCYIQGSIDFIFGNAKSLYQDCQIISMANQVSPGSKSVNGAVTANGRNSKDENSGFAFVNCTIGGTGHVWLGRAWRPYSRVIFVSTYMTDVIASEGWNNFNDPSRDATIFYGEYNCSGPGADVSKRAPYVQKLNDTQVAEFVNVTFIDGDQWLQLSDL
125
Q7QJ74
2.7.11.1
ACT_SITE 194; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000605-50"
MAGVFDLELHEEEDLRDSDDDIIDIEDVDLEPELHINTNLETEGSETIPLSEDIINPGRIKLGPQDFELKKVLGKGGYGKVFQVRKTTGADANSYFAMKVLKKASIVRNQKDTAHTRAERNILEAVRHPFIVELVYAFQTGGKLYLILEYLSGGELFMHLEREGIFLEDTACFYLCEIILALEHLHNLGIIYRDLKPENVLLDAKGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGMPPFCADNRKKTVDAILKDKLNIPGYLTPDSRDLIRRLMKRQVSQRLGSGPTDGQAVRAHPFFKNVNWDDVVKRRLDPPIKPVLASEDDVSQFDTKFTKEIPVDSPDETTLSESVNLIFQGFTYVAPSVLEDMQSRITMPRSPRRMHRHNLHQHHQHNHHHGSAHHHHHGAGSSRMMGGAGGTGATPMENGSGSSGAWKMAPHQNMHNHHPHVHRGGGQMVPPNQQQQQQPSSAQQPHNQTQPAGGAAGVSGGPPGSRPFNAASISRRTPPHLQPFAPRPSPQDEMMDVYPEMSIS
99
P00929
4.2.1.20
ACT_SITE 49; /note="Proton acceptor"; ACT_SITE 60; /note="Proton acceptor"
MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTLIDAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQCFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQVGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADDDLLRQVASYGRGYTYLLSRSGVTGAENRGALPLHHLIEKLKEYHAAPALQGFGISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLASPKQMLAELRSFVSAMKAASRA
202
Q8BZ25
2.7.11.1
ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MVPHRARRLLNPMAVGPLAQQLGSLTVFTRDDFEEEWHLVASGGFSKVFQARHKRWRTQYAIKCSPCLQKETTSSEVTCLFEEAVKMEKIKFQHIVSIYGVCKQPLGIVMEFMASGSLEKTLPTHSLCWPLKLRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPEYDVYSFAIVIWEILTQKKPYAGLNMMTIIIRVAAGMRPSLQDVSDEWPEEVHQMVNLMKRCWDQDPKKRPCFLNVAVETDMLLSLFQSPMTDPGCEALTQKVSCKPSLSQPHKVSKEVNQEIADSVSSDSLKWILQLSDSKSLVASDVYENRVTPLHFLVAGGSLEQVRLLLSHDVDVDCQTASGYTPLLIATQDQQPDLCALLLAHGADTNLADEDGWAPLHFAAQNGDDHTARLLLDHGALVNAREHEGWTPLHLAAQNNFENVARLLVSRQADLSPHEAEGKTPLHVAAYFGHIGLVKLLSGQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKCGALPDALDHSGYSPLHIAAARGKDLIFKMLLRYGASLELRTQQGWTPLHLATYKGHLEIIHQLAKSHVDLDALGSMQWTPLHLAAFQGEEGVMLALLQCGANPNAAEQSGWTPLHLAVHKGTFLGITHLLEYGADIHACNKVGWTPAHLAALKGNTAILKVLVKAAAQVDVKGGVSCTPLQLAIHSPK
99
F4K6B8
2.7.11.1
ACT_SITE 882; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MPRNPRFCFFLFLLFHSSLFFSIPCFSIDEQGLALLSWKSQLNISGDALSSWKASESNPCQWVGIKCNERGQVSEIQLQVMDFQGPLPATNLRQIKSLTLLSLTSVNLTGSIPKELGDLSELEVLDLADNSLSGEIPVDIFKLKKLKILSLNTNNLEGVIPSELGNLVNLIELTLFDNKLAGEIPRTIGELKNLEIFRAGGNKNLRGELPWEIGNCESLVTLGLAETSLSGRLPASIGNLKKVQTIALYTSLLSGPIPDEIGNCTELQNLYLYQNSISGSIPVSMGRLKKLQSLLLWQNNLVGKIPTELGTCPELFLVDLSENLLTGNIPRSFGNLPNLQELQLSVNQLSGTIPEELANCTKLTHLEIDNNQISGEIPPLIGKLTSLTMFFAWQNQLTGIIPESLSQCQELQAIDLSYNNLSGSIPNGIFEIRNLTKLLLLSNYLSGFIPPDIGNCTNLYRLRLNGNRLAGNIPAEIGNLKNLNFIDISENRLIGNIPPEISGCTSLEFVDLHSNGLTGGLPGTLPKSLQFIDLSDNSLTGSLPTGIGSLTELTKLNLAKNRFSGEIPREISSCRSLQLLNLGDNGFTGEIPNELGRIPSLAISLNLSCNHFTGEIPSRFSSLTNLGTLDVSHNKLAGNLNVLADLQNLVSLNISFNEFSGELPNTLFFRKLPLSVLESNKGLFISTRPENGIQTRHRSAVKVTMSILVAASVVLVLMAVYTLVKAQRITGKQEELDSWEVTLYQKLDFSIDDIVKNLTSANVIGTGSSGVVYRVTIPSGETLAVKKMWSKEENRAFNSEINTLGSIRHRNIIRLLGWCSNRNLKLLFYDYLPNGSLSSLLHGAGKGSGGADWEARYDVVLGVAHALAYLHHDCLPPILHGDVKAMNVLLGSRFESYLADFGLAKIVSGEGVTDGDSSKLSNRPPLAGSYGYMAPEHASMQHITEKSDVYSYGVVLLEVLTGKHPLDPDLPGGAHLVQWVRDHLAGKKDPREILDPRLRGRADPIMHEMLQTLAVSFLCVSNKASDRPMMKDIVAMLKEIRQFDMDRSESDMIKGGKCEKWQPQPLPPEKIVSTPRGSSNCSFAYSDESV
99
C4LY84
3.2.1.143
ACT_SITE 229; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 247; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 248; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"
MENKIIQTSTLSIEKIRTAITKEFKTCQDVVEFFINQEEERTNKKINKGVGDGYEIALKSFYNKVHSLGVTKKSFEEYFQWFIGGLKNAMNKLINNNDGNLEKNQSTIYIPISKSGTPSTIQIKRWEIFGILACSFFNVQWDKKVERIGNLSFVYISTNSRISIQRLICIFAYFHVMIEMDEKTLQEIVTYERVIQKKPYDWEHNETPIKTYPFVSGGLEMSEMNVHVDFANKYLQIHKIVPSITQEELLFSVRPECLISLILFEVLLDNEAVLIKNTLHISLSEGYQQTFKWIGFCKNQILKQPNIILAIDSVINSCFGKENIDRDLNKCMIGFQCAGNKIATGQWGCGSFGNDQLLKMAQQYMVLSTLGLEASIHWMNFSRYNELNDYMEICKSKKMTVKDIYYILCSFDGDKNTFVDYFKQQVQSFHK
159
A0A9J7NAQ0
3.5.4.5
ACT_SITE 68; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
MAEKSAASAGLTDEQIHELVQKSHQAKQRAYAPYSNFRVGAALHTEDGTIFTGCNVENASYPLCCCAERTAIFNAVTEGCRTFRAMAVATDVESEFLAPCGSCRQVMREFGTDWTVYLTKPDLSYRTMTVGELLPCSFGPDDLNKPKVKGQ
187
Q39238
2.7.11.1
ACT_SITE 539; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSDDMVLHFSSNSSNQSDHSLPDKIAKLEARLTGKTPSSAKPPQQQQQQQQQVSLWSSASAAVKVVTSTPPGLSETSISDSDDENTGDFLIRANTKKRQKVQESNNFSVVDHVEPQEAAYDGRKNDAESKTGLDVSKKKQGRGRASSTGRGRGSKTNNDVTKSQFVVAPVSAASQLDASDQKDFRPDGQLRNGECSLQDEDLKSLRAKIAMLEEELRKSRQDSSEYHHLVRNLENEVKDLKDQEQQGKQKTTKVISDLLISVSKTERQEARTKVRNESLRLGSVGVLRTGTIIAETWEDGQMLKDLNAQLRQLLETKEAIERQRKLLKKRQNGDKNDGTDTESGAQEEDIIPDEVYKSRLTSIKREEEAVLRERERYTLEKGLLMREMKRIRDEDGSRFNHFPVLNSRYALLNLLGKGGFSEVYKAYDLVDHRYVACKLHGLNAQWSEEKKQSYIRHANRECEIHKSLVHHHIVRLWDKFHIDMHTFCTVLEYCSGKDLDAVLKATSNLPEKEARIIIVQIVQGLVYLNKKSQKIIHYDLKPGNVLFDEFGVAKVTDFGLSKIVEDNVGSQGMELTSQGAGTYWYLPPECFELNKTPMISSKVDVWSVGVLFYQMLFGKRPFGHDQSQERILREDTIIKAKKVEFPVTRPAISNEAKDLIRRCLTYNQEDRPDVLTMAQDPYLAYSKK
99
H3GS17
3.1.1.11
ACT_SITE 205; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MHTFALPLLALASLATSTLAAIDCTSNGANARTQPPSGAVVVDASGAYKGSYQTVSEGVANIPNTTAEHTLFVFPGVYHEQVIVPKFNGPLVLQGYTCDTKSYADNQVTVTHTMAQRDLPANTTGALNALVSTMLFKSRNGVKVYNLNIANPTGKIKQLGQAVATYVDNTDYGFYACNFTGYQDTLCANKGKELYARSYIAGAVDFVFGLQSKAWFESCDIESVGKGSITANGNGNSSNLSEYVFNNARVFGALGNGTAYLGRPWYPYARVVWQNSNLSDVINPQGWQTWNKDNNTGNVYFKEFNNVGAGAATDERVAFGGQLTASVDITEILGKDYKSNWWVDASFL
125
P54350
2.7.10.2
ACT_SITE 361; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MAFRQSEHEMSVTSLDSSVELRSRSPSPQVFNPRKLRFADDDFDKDTPEGASPQHPLQQRPKLSSGEEQQLDSKIGKEGGDGDVSMSPPCQKVRALRLFSTPATPKTILQKSTTQCSNHLSAAAAAVNASRRSDDLFRLSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDACDDDVTEEAGDSMREIHQQAPKRLALHDTNISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHMLIQNEFCDGGSLHARIQDHCLGEAELKIVLMHVIEGLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQTKDDDGMDSVYEELRHSENLVTYKIGDLGHVTSVKEPYVEEGDCRYLPKEILHEDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWHNLRDGKVPILPSLSRDFNELIAQMMHPYPDKRPTSQSIFSHPILSAVDSKSKLQLGLELTVEKRKNEILMNKLREAKKQIKLLEQRVNLLAVTNNPDSLDGQRCLRSFTRRMRTPFSSHGKFDSISDRNKNVITNI
98
A0A804HY81
3.1.1.11
ACT_SITE 388; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MGNNKVAVLSISAIVLVAVVATVAVTVSNRRSQSADPQLSTSVKNVQDFCRPTDYKETCENTLSSVAGPDADPKELLNLAFNITVKHINDAIDHSTVLSEAAKDPSTSEALENCRELLDYAIDDLRRSVDRLGDFSVANLDKFLDDLKIWLSATITYQETCVDGFEGTTTNAGESMRKMLNSSSELTSNILAIVNNFDDTLSSLNLPINRKLLAEGYPSYVTPGKRRLLATSTADLKPNVVVAQDGSGDVKTIGEAISRVPNKGADIFIIHIKEGEYKEKVHVNKSATNVMLIGDGPTKTKITGSLNYVDGTRTFDTATVAVVGDGFVAKDLWIENSAGAEKHQAVALRVQSDMSVFYNCRIDGYQDTLYVHTHRQFYRDCTISGTIDFIFGDSASIFQNCLILARKPLDNQQNIVTAQGRKMRQQASAIILHNCTISADPAYYDFRTKLPTFLGRPWKMYSRTFILQSQIDDLIHPDGWLPWFGDFGLNTCFYTEVDNRGPGADKSKRVTWKGVKNIDYAHAKKFSVQQFLHGGKWLPRTGVPFTAELLPEGSLK
125
Q6ZLF6
3.1.1.11
ACT_SITE 383; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MASMCSRSIPQLILLLSLTVFLLANAHPMAPPSPPRKAAAPPTAAKGVTGISPVLVSTLRETLDAIKNVASIISSFPIGGILGGGDLRLSSAIADCLDLLDLSSDELSWSMSTTSSSSYQPTNAGAATSSHVGTGDARSDLRSWLGGALSNQDTCKEGLDDTGSVLGSLVGTALQTVTSLLTDGLGQVAAGEASIAWSSSRRGLAEGGGAPHWLGARERRLLQMPLGPGGMPVDAVVAKDGSGNYTTVSAAVDAAPTESASRYVIYVKKGVYKETVDIKKKKWNLMLVGDGMGVTVISGHRNYVDGYTTFRSATVAVNGKGFMARDVTFENTAGPSKHQAVALRCDSDLSVFYRCGFEGYQDTLYAHSLRQFYRDCRVSGTVDFVFGNAAAVFQNCTLAARLPLPDQKNSVTAQGRLDGNMTTGFAFQFCNVTADDDLQRALAGGGNQSSAAAVTQTYLGRPWKQYSRVVFMQSYIGAVVRPEGWLAWDGQFALDTLYYGEYMNTGPGAGVGGRVKWPGFHVMTSPAQAGNFTVAQFIEGNMWLPPTGVKYTAGLTS
125
P41415
2.7.11.1
ACT_SITE 137; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MATTNATLQTLVQFYENCKNVKTRYKIINGRFGKISILSHKPTSKLYLQKTISAHNFNADEIKVHQLMSDHPNFIKIYFNHGSINNQVIVMDYIDCPDLFETLQIKGELSYQLVSNIIRQLCEALNDLHKHNFIHNDIKLENVLYFEALDRVYVCDYGLCKHENSLSVHDGTLEYFSPEKIRHTTMHVSFDWYAVGVLTYKLLTGGRHPFEKSEDEMLDLNSMKRRQQYNDIGVLKHVRNVNARDFVYCLTRYNIDCRLTNYKQIIKHEFLS
99
A0A0K9Q1K1
1.11.1.7
ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MANYNSLRTKLTTMLKLVVVLSLSLLAAGVNGELNVGFYQNTCPNAESLIQQAVSDAFANNSGVAPGLLRMHFHDCFVRGCDGSVLLDGNDTEKTSIPNLSLRSVAFDLIDDAKTAVEKECPGIVSCADILAFAARDSANLTGGVTWDVPAGRRDGNMSIASEALTNLPPPSFNATQLVDRFKEKNLTAEEMVLLSGAHTLGRSHCVSFTKRLYQNTSIPDSAAQTDPTLSLAYADLLRNLCPSNSNATDTVTTLMDLITPNTLDNKYYLGVMNNLGLFKSDQALMTQDDLLAFVQEFNANATEWATKFGAAMVQMGRFDVLEGTNGEIRTNCRAVNAANSNSATVKNLLINMYRNYEEW
14
Q8ZYG2
3.5.4.5
ACT_SITE 53; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
MEDLVKIATNIIDRAYAPYSKFKVASIVKTKSGKIYTGVNIENASYGLTICAERVAVFKAVSEGDRDIDTVIIYTDTDEPTPPCGACRQVIAEFNPNALIVMASRKKVITQRLSELLPNVFSLKPSQ
187
H2LQD3
2.7.10.2
ACT_SITE 952; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1"
MPLNKREEDSTPLVIRDRGGSQTSSSSVTPGLQVHLYYFPDTKAGTTIHISSKQISAENVCIKAGEICGILPVYIDLFGLTSADMSFWYPPSHMFDSDENLEVHFRVRFFFRNWLGQGSRASCRYSLTRDRISPVLDYNVIDYLFAQMRSDFISSRCGVEPPLSVQEECLGLAVLDLWRMAKERHQSIRELCKTVSYKSCLPKSHRHDIQKRNRLDRYRIRNTLKRFLKKLGNCSVDECSLKIKYLMELAGIEPSMGSETFHVSHFSSQSKAPFKLVRVTGDTGIQTSGDDDSDGPPKWETFCDFGEIIDISIKRVCQDQASQDSRMVTITHKDDRCLEVNFKSLKEAFSFVSLVDGYFRLTTDSNNFFCQDIAPPSILYRNKNDCHGPITSEFAVNKLKKSGCRGGTFLLRQSPKNYGKYFLTVCVQTELGLDYKDCLIIKNEHYTLPGVQKFFSSLKELTSYYQMNMLLLAEIPVKLARCCPPRPKELTNLIIIRNSSAVEVQGSPIPDRNKFSHIQFQMIKYEDLKWVESLGQGSFTRIFKGYKTYTLDGEKHQTEVLLKELDAAHKNYWESFFEAASLMTQISHKHLLFVYGVSVHGVKNIIVQEFVKHGALDLYLKRARSVSVSWKLNVAKQLACALSFLEEHNIVHGNICAKNLLLAREGDKGSSPFIKLSDPGISVAMLDKDVILDRIPWVAPEVLEAPENLILESDKWSFGATVWEIFNNGNSLLQGWNLEKKQKFYEKRHHLPPSQWTELADLIDQCMDYEAAFRPSCRSIIRQLNSLITSDYEILHSTEPVTQSPMFRNLSPDELEHPLFEERHLCYISHLGKGNFGSVELCRYDPLCDNTGELVAVKKLQTNKQSSLEDFQREIKMLSALHFDYIVKYKGICYSMGRRSMSLVMEYLPYGSLIGYLERNQHNITTRRMLLFASQICQGMEYLQSQRYVHRDLAARNVLVASDSLVKIADFGLTKVIPSDKEYYRVSQPGESPIFWYAPESINECRFSHKSDVWSFGIVLHEIFSYCDPNCNPKRLYMQEIGHNMQGASISMHLANILKNNWRLPAPPNCPPKVHSLMHQCWLYGFDERPCFSSLGSQIESIMQDERENLKG
98
P29340
2.3.2.23
ACT_SITE 115; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133"
MPNFWILENRRSYTSDTCMSRIVKEYKVILKTLASDDPIANPYRGIIESLNPIDETDLSKWEAIISGPSDTPYENHQFRILIEVPSSYPMNPPKISFMQNNILHCNVKSATGEICLNILKPEEWTPVWDLLHCVHAVWRLLREPVCDSPLDVDIGNIIRCGDMSAYQGIVKYFLAERERINNH
64
Q59Q46
1.1.1.205
ACT_SITE 333; /note="Thioimidate intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_03156"; ACT_SITE 435; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03156"
MVFETSKATSYLKDYPKKDGLSVKELIDSTNFGGLTYNDFLILPGLINFPSSAVSLETKLTKKITLKSPFVSSPMDTVTEENMAIHMALLGGIGIIHHNCTSEEQAEMVRKVKKYENGFINDPVVISPEVTVGEVKKMGEVLGFTSFPVTENGKVGGKLVGIITSRDIQFHEDNKSPVSEVMTKDLVVGKKGISLTDGNELLRSSKKGKLPIVDAEGNLVSLISRTDLQKNQDYPNASKSFHSKQLLCGAAIGTIDADRERLDKLVEAGLDVVVLDSSNGSSVFQLNMIKWIKEKYPELQVIAGNVVTREQAALLIEAGADALRIGMGSGSICITQEVMACGRPQGTAVYGVTEFANKFGVPCIADGGIGNIGHITKALALGASCVMMGGLLAGTAETPGDYFYRDGKRLKTYRGMGSIDAMQQTNTNANASTSRYFSEADKVLVAQGVSGSVVDKGSITKFVPYLYNGLQHSLQDIGIKSIDELRENVDNGEIRFEFRTASAQFEGGVHGLHSYEKRLHN
3
W5MYR2
3.2.1.52
ACT_SITE 340; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MAALVKFVFLLFGATACLGWQNNLADVPKLTVSAYGSLWPLPQSVHISPVAFRVSSFGFQIVHSPKSSAGPSCFLLQNAFRRYFEYTFGYSKKLKGDLKMVANDSEVFELQVWISSENPECDSYPSVKSDESYELSIDQPTAVLKAPKVWGALRGLETFSQLVYADKYGTNYINKTDIQDFPRFAHRGILLDSSRHYLPLKVILANLDAMAMNKYNVFHWHIVDDHSFPYQSTAFPNLSTEGSYHPYTHVYTPTDVKMVIEYARMRGIRVVAEFDTPGHTQSWGLGQKGLLTPCYAGDTPTGTFGPVNPILNSTYEFMTQFFKEVSSVFPDMYIHLGGDEVDFSCWKSNPDIQKFMDTQGFGKDYSKLESYYIQKILEIVAGTKKGYMVWQEVFDNGVKIKPDTVVEVWMGNKLEEELKKVTGAGFTTILSAPWYLDYISYGQDWQRYYKVEPLDFEGTEAQKKLVVGGEACLWGEYVDATNLTPRLWPRASAVAERLWSDKDVKDIGDAYSRLTQHRCRMVQRGIPAEPLYVGHCEHEYKGL
170
Q6AVZ3
1.11.1.7
ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAVSSPAPSSLHVPMAAAALLGMLMMMSSAPEMKVEAAGGLSVGFYAESCPKAEAIVRDTVTKAFEKAPGTPADLIRLFFHDCFVRGCDASVLLESTPGNKAERDNKANNPSLDGFDVVDDAKDLLEKECPHTVSCADILSLVARDSAYLAGGLDFEIPTGRRDGFVSKEDEVLSNVPHPEFGAKDLLKNFTAKGFTAEEMVTLSGAHSIGTSHCSSFTNRLYKYYGTYGTDPSMPAAYAADMKSKCPPETAAQQDATMVQLDDVTPFKMDNQYYRNVLAGNVTFASDVALLDTPETAALVRLYAAGDPAAWLARFAAALVKVSKLDVLTGGEGEIRLNCSRIN
14
Q9I4W5
1.11.1.24
ACT_SITE 45; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MPVAIDKPVPDFTAPATSGKEVTLSALKGKQVVLYFYPKDSTPGCTTEGQGFRDQYAAFQKANTEVFGISRDGLKSHENFKCKQEFPFELISDKDEAVCQLFDVIKLKKLYGKEYMGVDRSTFLIDRDGVLRQEWRGVKVPGHVDAVLAAAQALNGA
12
A0A9R1X0R4
1.11.1.7
ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAYKKHISSLLLQLILLAFVFVSANGSYLKLGFYQKTCPNVEAIVAKVTADHISVAPSLAAPLLRMHFHDCFIRGCDGSVLLDSTKTNAAEKVGPPNLSLRGYQVIDAAKSALEKECPGVVSCADILSLVARDAVYQIKGPWWPVPLGRRDGRVSIALESLSLPAPFGNIAQLKAQFASKGLSVKDLVVLSGGHTIGTSQCSTIVIRLYNFTGKGDTDPTLDPKYVPFLKKKCKPTDTTTLLEMDPGSFRTFDEDYYTIVMKRRGLFQSDAALLDDKETSAYVKFQAQSHGSTFFKDFEESMVKMGQIEVLTGSAGEIRKHCALVN
14
A0A804KEY6
1.1.1.8
ACT_SITE 232; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1"
MAPSIEGKRPEVKSPMNTTCCNREEITPRYRVTVVGSGNWGSVAAKLIASNTVKLPIFHDEVRMWVFEEILPGGEKLSKAINQTNENVKYLPGIKLGKNVIADPDLENAVKEANMLVFVTPHQFVAGICKRLVGKIKPNTEAISLIKGMEVKTEGPCMISKLITDMLGINCCVLMGANIANEIAVEKFSEATIGYKQDKEVAQRWARLFCTPYFLVSVVQDVEGVELCGTLKNVVAIAAGLVDGMNMGNNTKAAIMRIGLREMRALSKLLFPSVRDSTFFESCGVADLITTCLGGRNRKVAEAFAKSGGKRSFDELEAELLGGQKLQGVSTAKEVYEILSHRGWQAIFPLFTTVHEICIGQLPSSAIVEYSEQATNFSIVEGLAQYC
7
A0A1U8AT85
4.1.1.17
ACT_SITE 369; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MAYEQLRAMGSSHKSLQAVLAAPGVKVKKVTSLSADGLTDFIQSMISKKQEMKDPFYVLDFGVVVSLMDKWKRSLPNVRPFYAVKCNPHPAFLAALAALGVSFDCASRAEIEAVLALGVSADRIIYANPCKAEAQIKYAASVGVNLTTFDSREEIDKLRRWHPKCSLLLRLKAPDDGGARCPLGPKYGALPEEVTPLLQAAHVARLTVAGVSFHVGSGATHSRAYSGAIAAAKAVFDTAVGLGMPRMSILNVGGGFTAGVGPQFEDAAATINAAIKVHFLDESGLTVIAEPGRFFAETAFTLATNIIGKRVRGKLREYWINDGIYGSMNCILYDHATVTATPLACTSNRSNPTCRGGKTYTSTVFGPTCDALDTILTGHQLPELQVNDWLLFPNMGAYTASAGSNFNGFNTSAIPTHLAFSPPAPC
195
Q4X262
2.7.11.1
ACT_SITE 243; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MATKALEARFEHLSVKDDADHGRNGSTYSKHKGSLSTAVSLSGLGAAGQFNSGSSRSTLLKLALQNTNENKVNAMHTGSSPLKGAQSTLAHRDTDENGESRHTTPLYEQPGPKKLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFHDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLKPNPQDNYYSEKVDLWSLGVLTYEFLVGEAPFEDTPVMTQRRIARADMTVPSFVSPEAKDLIKRLLVLDPDKRISLDEIQRHPWILKHCLKDDRVTKQSSGSSKEVKA
99
Q9Y7R8
1.1.1.37
ACT_SITE 205; /note="Proton acceptor"; /evidence="ECO:0000250"
MFAKVAFKNFTPLKSIAPRSFSTTSSRAFKVAVLGAGGGIGQPLSMLLKLNDKVSELALFDIRGAPGVAADIGHINTTSNVVGYAPDDKGLEKALNGADVVIIPAGVPRKPGMTRDDLFATNASIVRDLAFAAGETCPEAKYLVVTNPVNSTVPIFKKALERVGVHQPKHLFGVTTLDSVRASRFTSQVTNGKAELLHIPVVGGHSGATIVPLLSQGGVELTGEKRDALIHRIQFGGDEVVKAKAGAGSATLSMAYAGARMASSVLRALAGESGVEECTFVESPLYKDQGIDFFASRVTLGKDGVDTIHPVGKINDYEESLLKVALGELKKSITKGEQFVA
5
Q4CUJ8
3.1.3.48
ACT_SITE 75; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q4QEZ7"; ACT_SITE 107; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
MGANGTLVECKRGESDAVVFRFLIFDAPSPSSVTAYVKLMQKYNVRHIVRACGQTYSAEAFEKQGMVVHGWSFDDGAPPTQTVIDNWLNLLEQEKNKSPPETIAVHCVAGLGRAPILVALALVEYGGMPPLDAVGYVRGRRKGAINQVQLNWLMRYKPRHQEGNEGSLSCAGCAVM
149
P19406
3.1.3.1
ACT_SITE 108; /note="Phosphoserine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10042"
MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQDKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPDYNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHATPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQAGYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKGFFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGGFTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEAAAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQANIIFKILKTGK
141
F6PYU7
2.7.1.11
ACT_SITE 166; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184"
RKLRKSVSSPLIGSGRCIAVFTSGGDSQGMNAAVRAIVRMGITCGAKVYLIHEGYQGMVDGGENIVEAAWDDVSGILQMGGTVIGSARCKDFREREGRLKAAFNLVTLGITNICAIGGDGSLTGANLFREEWSSLLQELVETGKINQEQATIHSHLNIVGLVGSIDNDFCGTDMTIGADSALHRIVECVDAITTTAVSHQRAFVLEVMGRHCGYLALVTGLACGADWIFIPEHPPADGWEEKMCGKLNNARSWGNRLNVVIVSEGAIDCHGNAITSQQVKEVICKRLDLDTRITVLGHVQRGGSPSAFDRLLGTRMGAEAVLALLEATPETPAYVVSLDGNQAVRVPLMECVEKTKEVTKALAEKDFDRAASLRGRTFQGNLEIYKKLGAMSKAKSDKQKPYNVAIMNVGAPAAGMNAAVRSAVRTCLYNGYKALVVHNGYEGLANDMVETYTWKCVANFVAAGGSKLGTKRTLPSQCGFDKISEIINKRNIHGIICIGGFEAYHGSLEIKEASQAYPALQIPLIVVPATLSNNVPGTDISIGSDTGLNSVCETCDRIKMSASGTKRRTFVLETMGGYCGYLATMSGLAAGADAAYIFEEEFTIKDLQKNIYHLRNKMKGKIQRGLILRNEKANDNFSTDFVHRLYAEEGKNVFDCRVNVLGHMQQGGVPSPFDRNYATKSAAKAAFWILDKIENNLVDGKVVCNSQDSVVLLGMRRRQMLFQPVEDLKADTDFKHRIPNQQWWMQIRPLLRIMAHYQ
84
Q8I2Z8
2.7.1.11
ACT_SITE 313; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03185"
MDTKSGDKNAANKGGADGLVKTVSVLLRDNKCQFNIDENYDHNDKEKLECEVGKRDSGMINCLMEKLTSKKFLEEKESKNSFYLVDNENMKIKKLKEHGHSASLNDDLSPLQYERTKYIPSLPKALASEYQILDENYGDEFINKNDYEDVKRFLKNLHNLPMLNVKDSNNNESFKGGNILKIGIILSGGPAPGGHNVISGIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTITDSMMNRFRNLGGFNMLWSGRGKVKNKDDLIAIENIVAKLKLNGLVIIGGDGSNSNAALMAEYFAERQIPISIIGVPKTIDGDLKSEAIEISFGFDTATRTYSEIIGNLCTDVKTGHNVYHVVRVMGRSASHVVLECALQTRPNVVLIGEEVEQLNLSLKDIVKNIVNIILKRKSLNKNYGVILLPEGLIEFVPEMKILISELNVILKDGPFDASKLQKSKEVWDFLPPIIRDQLLMDRESTGYIQVGKIATERLIIVLVESELAKLNDKNLNIQFMSHYLGYEGRCAIPSNFDCNYCYALGYNAALLIDHKKTGYMSIIRNLEDSYTNWIPAAIPFLRIMHVIKDNTGNEFPAVKRYLVDLNSPLFNVLKEVRSLWSLYDLYRSPGPIQFNGHLGNARCYTVKTPTKDNLLCQNADDLELIINLTNKNMYENNGDNNHNISDDKARDGGSSPTSSAKKTKYNLSDDNNNNNNNNINNVSTNYNNTSDGSTFGNTTLLNTAYNVNGDGMNTLNCQKSNTSDVLSSEPVNQGFYEQHASSYKSLGCMSELQTSRLYNKLELPELCSDLKAKVRAGKQYISNDPYTQKQILSNYPHMSYENKFQIQEIFHDKYASPISFEIRIGIVFLSRQAPGAMNVLCGLYRRLKLLKGVCIAFYGLYGLLHNKYIIIDDDNIAKYVNQGGLELTGNSPEHSLFDKENRNKVCETVTKLQLNGLVMPGSNITITEAALLSEYFLEKKIPTSVVGIPLTGSNNLIHELIETCVGFDSSTKVYASLIGNVLTDAVSMPKYWHFIRLMGRSPSHEVLECALQTHPNVVIISEEYGAADKTLWRVVQDIADVVCARADVGKNYGTVLIPDALLMHLPHMKILLSEISDILNEASEKGQLLEARNDLVNLSGVDHGHLTSEWVSKLTPWSLALLKTFPQFIIKELLQVDLRSMRFEQLETEQLLLQMVKEELQDRKQKGKYSGSFMGLTHFFGYQGRSSLPSEFDCKLAYAYGHAASIVIESGLTGYIVSIRGLCGNVKDWKLFAIPFISLMKILPKGQGSKYLKSASKGDLPVIPSAPVDLNGKAYRSLKIALQKWQMEDRFCNPGPIQFEGNASNYYNRILFEEQSEYFEMLRYVECYANILKDTCRFGVSADYLKNVFVQLCGMLVLAYKPNDILSNMPYIGSIEDYYDWENQRKRMN
84
B9GPE1
3.1.1.11
ACT_SITE 228; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSSASTATIFLLLAIAATTTFCHQELEKSENFRTQTDQASEALAFNVKSGKGLKRRKPNGKLLTSWNPANSKADYVVAQDGSGTHKTINDALAALDKTGGNRRNQRVIVYVKAGVYNEKVVIKKNMEKLMFVGDGIDRTIVTGNRNAKRDGYATHETATFGVHADGFWARDMTFENTAGPDGRQAVALMVSSEQSVVYRCSFKGYQNTLYVRSKRQFYRDCHIYGTIDFIFGNAAVVLQNCDIFVRKPNENQKNVIVAQGRKGPDENTGISIQGSRIRPAPDFIGVKNIPTFLGRPWRKYSRTVIFETDIDGFIDPAGWLPWDGSVHLNTLFYAEYNNIGCGASTEHRAKWPGFHVFKSWKEASPFTVNKFIKGSSWISQTGVSYKLGV
125
A0A022Q2I2
3.2.1.23
ACT_SITE 199; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 282; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
MAGNRTAAVIFVIVIVFAAFAPLPSSSHRSSSQFRLDKGGEEKFEIADDMFWKDGEPFRIIGGDLHYFRVHPEYWEDRLLRAKALGLNTIQTYVPWNLHEPSQGHVVFEGFADLVSFLKLCKKLDLLVMLRVGPYICGEWDLGGFPGWLLAKEPPIRLRSSDPVFLNLVEKWWSILLPKVFPLLYSNGGPIIMVQVENEFGSYGDDKAYLHYLVKLARTHLGDDIILYTTDGGARDTLEKGTLKGDDVFSAVDFTTGDDPWPIFNLQKEFNAPGKSPPISTEFYTGWLTHWGENIASTDASFTATYLEKILSKNGSAVLYMAHGGTNLGFYNGANTGDNESDFKPDLTSYDYDAPIRESGDVDNAKYKALRRVIAKYSAKPLASIPPDNERIAYGRIQLDKVSYLYDMIGMKDLVDLVESENPSSMEAIGQMFGFVLYASEYTPKSNGSVLSIPKVHDRAQVFISCPEDSEKRPTYADVITRWSNRPIHLPYLKCESNNNLFILVENMGRLNYGPYMFDRKGILSSVYLDSTPLYKWKMLPLSLQNVNESPKIDPIISNTIKTASLKGSARKKLIGKKLNFEPAFYTGHFNIDKVRDTYISFRGWSKGIAFVNEINVGRFWPSVGPQCNLYVPAPILREGNNTVVILELESPKPDLTVSSVDHPDFTCTSKLGKSRGRLVLTS
163
A0A9R0IZZ0
1.11.1.7
ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSIKMNIHSSVRFLVLFSVLSCLSVQLEAQLQVGFYCESCPSAERIVREEVMKGFMNDKGVAPGLVRMHFHDCFVRGCDGSVLIDSTSSNTAEKDSPANNPSLRGFEVIDSAKTRLEAECKGVVSCADILAFAARDSVAMTRGQRYDVPSGRRDGRVSLVSEVFQNIPGFTFNVTRLTQSFANKNLTQEEMVTLSGAHTIGRSHCTSVSNRLYNFSGTNGADPTLDSKYAGQLQQQCPQGSTNSNQVVPMDPVSPFITDVNYYQDVLANKGLFTSDQTLLTDSNTANEVNQNARNQFLWMRKFAAAMVNMGQIEVLTGTNGEIRTNCSVIN
14
Q09850
3.2.1.39
ACT_SITE 457; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"; ACT_SITE 533; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"; ACT_SITE 537; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"
MDVLVPIYTGPINPVFPSRAHPSPPLGLTSNLFPIQTNKFYGNLYIGTRHNPSWSHPYSVTWLNGSSYYGLAISHIDDSQRVFGPDPESVPCQYYFNPAGLYSIIISAREFASGNLLSLDQSRHFSIQATLSATTSGSGTIILPIVAGMGFVSGYYTNLTPVFNSSILFSSITKINFSRGYKYRIQLTDGKIWFLYAFPTSSSSTFNLTLASNSQLTTSTKFTGLIQICKVPNESVNNSYPDTIYDASAGVYTTSISLSAQVSGTTGEYWFRFATAGYTNLNPLMFALPHHMQSFGSDTQAYKTGLGLASTTMGIMFAYATKTWHLIEKNLPTQVGFLPIPWNGGSNTYSPTALAAIRAACATDINFDVVNASNLDSMYTSGKIVAMYAQVCLVASRILGDSTLTNTGLTKLKQAMARFTTNTQMYPLVYDTTYKGIISTAGYSSPLADYGNTYYNDHHFHWGYHIYACAVIGLLDPSWLVNDNIRYVNALLRDSANPSESDTYFAMFRNFDWFVGHSWATGIFESGDGKDEESTSEDFNFLYATKLWGMVRNDTVLINRANLMLAVLKNSLNTYIYMTPTTSVQPSQILGNYVTGITFMNKVDYATYFSAEEYCKQGIHMIPTTPISGYLRSPSYVQQDWNAKIAPIINTFSNNWTGILWSNYAIYDPKTAYNTFAASTFTADKIDNGASKTWYLAMAAGMGGSP
167
A0A7M7PR52
5.1.3.3
ACT_SITE 124; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 258; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MGSTDRMAAQGYETNAPSFGVTIGRVVNRIAKGQFALDGVHYQLEINDGSNHIHGGVINFSHRLWEGHIEETGVSFSYTSPDGENGYPGEVFVTINYQLTDDNKLLISYVAKTTKATPINLTNHSYFNLGGHDSGSVTDHIVEIDADKYTPMVIETTIPSGEISSVDDTVFDLRSPTRIGDKINEVPGLGYDHNFCVKSSEKPCVMYVKHVTHKESGRKMEVSTTKPGIQFYTANYLNDSTVGKCGAIYPKHSALCLESQFYPNAVNQPNFPSCILQPGDMYTHLTAFAFSWN
211
A0A1U8AJA4
1.11.1.7
ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAALKLFSSVVFFIQLAIVVFHLDPTSAQGLRVGFYKNTCPAVEDIVRKTTAHYVLPVPSLAAPLLRMHFHDCFVRGCDGSVLLNSTANNQAEKSAIPNQSLNGFGIIDAVKSAVEKACPGVVSCADILALVARDAVSLVKGPYWEVPTGRRDGRVSLASEALTNLPPPFATISDLQTRFMAKGLSVKDLVVLSGAHTIGQSHCPSFTNRLYNFTGRADSDPSLDSIYIQRLKSKCKAGDVVTSVEMDPGSYKTFDTGYYKNVAKRRGLFQSDAALLNDADTKAYVIQQSTSSSGSSFFKDFGVSMVNMGNIGVLTASAGEIRKQCAFVN
14
P51954
2.7.11.1
ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTLSKFGPQPLPGKRPASGQGVSSFVPAQKITKPAAKYGVPLTYKKYGDKKLLEKKPPPKHKQAHQIPVKKMNSGEERKKMSEEAAKKRRLEFIEKEKKQKDQIRFLKAEQMKRQEKQRLERINRAREQGWRNVLRAGGSGEVKASFFGIGGAVSPSPCSPRGQYEHYHAIFDQMQRLRAEDNEARWKGGIYGRWLPERQKGHLAVERANQVEEFLQRKREAMQNKARAEGHVVYLARLRQIRLQNFNERQQIKAKLRGENKEADGTKGQEATEETDMRLKKMESLKAQTNARAAVLKEQLERKRKEAYEREKKVWEEHLVARVKSSDVPLPLELLETGGSPSKQQVKPVISVTSALKEVGLDGSLTDTQEEEMEKSNSAISSKREILRRLNENLKAQEDEKEKQHHSGSCETVGHKDEREYETENAISSDRKKWEMGGQLVIPLDAVTLDTSFSATEKHTVGEVIKLDSNGSPRKVWGKNPTDSVLKILGEAELQLQTELLENTSFKSEVYAEEENYKPLLTEEENLQCISKEINPSATVDSTETKSPKFTEVSPQMSEGNVEEPDDLETEVLQEPSSTHTDGSLPPVLNDVWTREKEAAKETELEDKVAVQQSEVCEDRIPGNVDQSCKDQRDPAVDDSPQSGCDVEKSVQPESIFQKVVHSKDLNLVQAVHCSPEEPIPIRSHSDSPPKTKSKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVHQDSLEIDELEDEPIKEGPSDSEDTVFEETDTDLQELQASMEQLLREQPGDEYSEEEESVLKSSDVEQTARGTDAPDEEDNPSSESALNEEWHSDNSDAETTSECEYDSVFNHLEELRLHLEQEMGFEKFFEVYEKVKAIHEDEDENIEICSTIVENILGNEHQHLYAKILHLVMADGAYQEDNDE
99
A0A072UP31
1.11.1.24
ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MPGLTIGDTIPDLEVDTTQGKIKLHHFCSDSWTILFSHPGDFTPVCTTELGKMAQYASEFNKRGVMLLGMSCDDLESHKEWIKDIEAHTPGAKVNYPIISDPKREIIKQLNMVDPDEKDSNGNLPSRALHIVGPDKKIKLSFLYPAQTGRNMDEVLRVVESLQKASKYKIATPANWKPGEPVVISPDVTNDQAKDMFPQGFKTADLPSKKEYLRFTNV
12
P54201
3.4.19.12
ACT_SITE 328; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 797; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"
MELFPELKNIKVPTEKSRLWKDECCYCFDTPENGEGLFIDLIGLLAFSKKYVQLNHQKTHHHLYLNFKKVAIVNEKVKSPTIENGGEEKPPKKLAIGVEGGFNVEDEEIKYEEHYKLYIFPDDKFLELSDPIIPENVRVCCEKIKTLNSQSRKEEIVSWNAESVFPSAFAESIIQLDNNTKKIDPKGPWRCDIEGCDKVENLWLNLTDGFIGCGRKYADGTGGNGHAQEHFNQTQYPISVKLGTITKDHADVYSYPEDDMVSDPLLFQHLTHWGLNPNVMVKTEKSMAELELDQNLNFEFGKIQEKGKLLENVFGPGLTGIENLGNSCYMSSVIQMIFAIDSFQTRYLKDREASFKDITQDPTQSFEIQMSKLAHGLLSGDYSIPLSKPSKNANEESEAATQIGIAPKMFKSLIGASHAEFSTMKQQDAHEYLQYLLEYIERAEHSRPSWIQQANPTRLFQFHNEDRIECGSSGQVKYTRRLENILSVPVNLDDATNKQEVAQYEETLKQQNGVRQKDQEEIRPIIPLVSCINGFVEPYRVEDFLSPATGVKTFSLNSSRMATFPEVLIIHLKKYTYNADYTPKKLNVFMDVPDIIDIDSLRGRGIKEGEVPLKEGTINTTTKVPEPSFNQEVLDTLLSMDFPLVRCKKALLATGGKDAELAMNWIFEHTEDPDIDIEQTPVNNNNNNNNSSNSNDKLFVFNSQDVDNIIGMGFTDSQAKLALKNTKGNLERAADWLFSHIDNLDELVAKDNASTSSINPSLIPQSTTSLQPVSDGVGKYELLGFISHLGNNVTCGHYVCHIKKNNRWIKFNDRHVQLSEQPPKELGYIYFYKRQLN
175
P53739
2.7.11.1
ACT_SITE 621; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MAGHHHEHEQERDHEQEHEHDSLQRPTTGSERTRSISFSKLLTRSWKRNASSSNNMSVSSVNLYSDPENSRESDHNNSGSEGQSSRFSKLKSMFQSGNSSKNASAHNSSQSSLEGDSASSSSKLRYVKPMTSVANASPASPPLSPTIPETDVLQTPKMVHIDQHEHEREHSNCGSPIMLSSSSFSPTVARTGTGRRRSPSTPIMPSQNSNNSSSTSAIRPNNYRHHSGSQGFSSNNPFRERAGTVRSSNPYFAYQGLPTHAMSSHDLDEGFQPYANGSGIHFLSTPTSKTNSLTNTKNLSNLSLNEIKENEEVQEFNNEDFFFHDIPKDLSLKDTLNGSPSRGSSKSPTITQTFPSIIVGFDNEYEEDNNNDKHDEKEEQQTTTDNKTRNLSPTKQNGKATHPRIKIPLRRAASEPNGLQLASATSPTSSSARKTSGSSNINDKIPGQSVPPPNSFFPQEPSPKISDFPEPRRSRRLRTKSFSNKFQDIMVGPQSFEKIRLLGQGDVGKVFLVREKKTNRVYALKVLSKDEMIKRNKIKRVLTEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCMGGEFFRALQTRKTKCICEDDARFYASEVTAALEYLHLLGFIYRDLKPENILLHQSGHIMLSDFDLSIQAKDSKVPVVKGSAQSTLVDTKICSDGFRTNSFVGTEEYIAPEVIRGNGHTAAVDWWTLGILIYEMLFGFTPFKGDNTNETFTNILKNEVSFPNNNEISRTCKDLIKKLLTKNESKRLGCKMGAADVKKHPFFKKVQWSLLRNQEPPLIPVLSEDGYDFAKLSSNKKRQTSQDSHKHLDEQEKNMFEERVEYDDEVSEDDPFHDFNSMSLMEQDNNSMIYGNTNSYGKIAYTPNSNRSRSNSHRTFFKR
99
Q9HGI3
3.2.1.52
ACT_SITE 225; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q06GJ0"; ACT_SITE 278; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q06GJ0"; ACT_SITE 349; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q06GJ0"
MAYFRLYAVLLAVASSVAAVKVNPLPAPRHISWGHSGPKPLSDVSLRTERDTDDSILTNAWNRAWETIVSLEWVPAGIEAPIPEFDEFPTSTPSASAAATRSKRANVPIQFVDVDVEDWDADLQHGVDESYTLDAKAGSDAIDITAKTVWGALHAFTTLQQLVISDGNGGLILEQPVHIKDAPLYPYRGLMVDTGRNFISVRKLHEQLDGMALSKLNVLHWHLDDTQSWPVHIDAYPEMTKDAYSARETYSHDDLRNVVAYARARGIRVIPEIDMPAHSASGWQQVDPDIVACANSWWSNDNWPLHTAVQPNPGQLDIINPKTYEVVQDVYEELSSIFTDDWFHVGGDEIQPNCYNFSTYVTEWFQEDPSRTYNDLMQHWVDKAVPIFRSVSDSRRLVMWEDVVLNTEHADDVPTDIVMQSWNNGLENINKLTERGYDVIVSSADFMYLDCGRGGYVTNDDRYNEQTNPDPDTPSFNYGGIGGSWCGPYKTWQRIYNYDFTLNLTNAQAKHVIGATAPLWSEQVDDVNISNLFWPRAAALAELVWSGNRDAKGNKRTTLFTQRILNFREYLLANGVMAATVVPKYCLQHPHACDLNYDQTVLH
170
A0A3B3HTZ2
3.1.1.4
ACT_SITE 75; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 120; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MMAFCRILLISSAVAVASVAAHSSQRTRRGLLELAGAIKCSTGRSALAYMMYGCYCGLGGQGWPRDRADWCCHRHDCCYGDAELLGCHTKTAQYHWTCEDRKAECDDLKDKCEKMLCKCDREAAKCLRKAPYIQKYALWPDFMCGSEHPMCNIY
130
A7SWM6
2.7.11.1
ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 473; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
FKKADPSQFELLKVLGQGSFGKVFLVRKVIGADAGTLYAMKVLKKATLKVRDRMRTMKERDILVDVQHPFIVRLNYAFQTEGKVYLILDFLRGGDLFTRLSKEIMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDASGHVALTDFGLSKESEHDQKTYSFCGTVEYMAPEVVNRRGHSQAADWWSYGVLMFEMLTGSLPFQGKDRKDTMNMILKAKLGMPQFLTPEAQSLLRQLFKRNPLNRLGAGDLGIEDIKKHPFFSTINWELLYKREIKPPFKPAAGRADDAFYFDPEFTSKTPQDSPAVPPSATCHQLFRGFSYVAPDIVEVETRGPAARAFPIRTTCILDEYEIKEEIGKGAYSSCRRCVNKADGKEYAVKIFEKPKKDPSEEMEILLRFGHHPNIVHLRDAYEAGKQVYIVMELMRGGELLDRILKHKCLSEREAGNIMYTLTSTIAFLHEEGVVHRDLKPSNIMYADDSGTPESLRIVDFGFAKQMRATNGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLSGLTPFAVGPEDTPSVILKRIGEGKYSLVGGPWDTASDLAKVK
99
A0A0K9NM84
3.1.1.11
ACT_SITE 402; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MERPTKKILLVLFCSVLLLAVVITITTTSAASRRKSKSFLTVASHAVVKQSCSSTLYPDLCFETLTSASTLLHSKSSQKDVILSSVNLTRTAVEHQYFKFSKIYGHNTSKLTEREKCAVHDCLEMIDETLYELRKVEDDLNVYPGGGVSLARQADNLETLLSATMTNQESCLDGFAHNSVCRKLRSSLEDGVMHVSKMCSNSLAMIKTMTGADIKAAGAVVDRRLSENEESGFPEWMSVGDRRLLQAKSVKANVVVAKDGSGDYKTISAAVKAAPEKSKSRYIIHIKSGKYKENIEVSKKKKNIMFIGDGRSKTIITGSRNVVDGSTTFRSATLAVVGERFLARDIRIENTAGPSKHQAVALRVGSDLSAFYNCEFIAYQDTLYVHSLRQFFTGCVVKGTVDFIFGNAAVVLQNCDLQARRPNKGQKNMFTAQGRDDPNQNTGISIHKCKIRAASDLAPVRSSFPTYLGRPWKKYSRTVVMKSSISNVIHPKGWFPWSGNFALSTLFYGEYANFGAGAGTSKRVNWKGHKVITRSSEATKFTPRSFIGGSGWLGSTGFPFKLDL
125
A0A1S4GU30
3.2.1.52
ACT_SITE 555; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
MLLSHDYNSRRSSIASTQSRNIRVTVLKNMFKKIALTRSALKKAIVVVSVCALASFLLLLYWNDSSESTKPSSTMAMGIYNTHIVDGSLDGGPMSAGDSVRDSAIPVNPIERLWTYRCVNNRCVRHHFVDGVEEDFDTNNAHQQQHGGQAPAGAGSANAGSSSSSPGKRIPYLTCTMTCGPINIWPQPTGATTIGSKTSRFRLSDMHVKIVTKFEPVDKLLHDAYDVLRAEVRAAMVSHGATLEEIEGAVPAASVPAGVQQLPRAEERSLATEVNDAATVGRSAGGSETSGVGKIHFFKLVSDKRYDVDAFEVNVHVEKSGDTHLTLHTDESYNMTVTHSARVLIVKITANTFFGAKHGLTTLQQLIWFDDEERTLKVLNKASIEDVPKFNYRGLMLDTSRHYFTVDAIKRTLVGMSHSKLNRFHWHITDSQSFPFVSRHYPQLARYGAYSEREVYTADDVRELTAFAKVRGIQIIPEIDAPAHAGNGWDWGPKHGLGELSLCINQQPWSNYCGEPPCGQLNPKNNNTYLILQKLYEELLEIVGPLDYFHIGGDEVNLECWQQHFNDSDMRTLWCDFMLQAYHRLQLASGQNATAPRLVGVWSSGLTSAPCLSKNTFAVQVWGGSKWPENFQLINSGYSLVISHVDAWYLDCGFGSWRSTGDGACSPYRNWQTVYKHRPWEEMKLTTLQMRQILGGEACMWTEQVDESILDARLWPRASALAERLWTDPTEERYSESVPLEVYNRMSVFRNHLLELGLRAEPIFPKYCAQNQDECV
170
H3G9S9
3.1.1.11
ACT_SITE 205; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MHSFALPLVALASLATSTAAAIDAPCNGPNARTQPPAGAIVVDITGTYNGSYQSVAEGMAYLPNTTEEHTVFLFPGVYQEQVIVPKLAGPLVLQGYTCDSMSYAENKVTITHTMAQRDLAPEIKNNRNALVSTMRLKSSSGVKMYNLNVANPTGKIDQLGQAIAAYVDAPNYGFYACNFTGYQDTVCAHKGPELFARSYISGAVDFIFGMRAQAWFESCDIETVGEGWITANGNVNSSNLSEYVFNRARVFGSSGNGSTYLGRPWQPYARVVWQNSELGDVVHPQGWSTWDDKTSTENVYFKEFNNSGPGAAIEQRVPFSGQLNASVDIKEILGEGFESAWWVDTKYL
125
Q7XRB5
5.3.4.1
ACT_SITE 61; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 64; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 407; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 410; /note="Nucleophile"; /evidence="ECO:0000250"
MAVNLVLSFALAILISSSPTAVGVDATEELKEAVLTLDAGNFSEVVAKHPFIVVKFYAPWCGHCKQLAPEYEKAASILRKNELPVVLAKVDAYNERNKELKDKYGVYSYPTIKIMKNGGSDVRGYGGPREADGIVEYLKRQVGPASLKLESAEEAAHSVVDKGVILVGVFPEFAGMEYENFMVVAEKMRADYDFFHTSDASILPRGDQSVKGPIVRLFKPFDELFVDSEDFGKDALEKFIEVSGFPMVVTYDADPTNHKFLERYYSTPSSKAMLFVSFGDDRIESFKSQIHEAARKFSGNNISFLIGDVADADRVFQYFGLRESDVPLLFVIASTGKYLNPTMDPDQIIPWLKQYIVEYGNLTPYVKSEPIPKVNDQPVKVVVADNIDDIVFNSGKNVLLEFYAPWCGHCRKFALILEEIAVSLQDDQDIVIAKMDGTVNDIPTDFTVEGYPTIYFYSSSGNLLSYDGARTAEEIISFINENRGPKAGAAAAVDEKTQIDAVEEEVTSSSEPVKDEL
215
Q5BAU6
4.1.2.13
ACT_SITE 84; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001359-1"
MPLNKPNPALSILDHASKNNYAVPAMCVYNVEGILATVRAANKKRSPAMIQLFPWALHYADGLLVHAAAEAAKSAEVPVTVSMDHAQTPEIIRRAADIGGFDSIMVDMSHYEKEENLRLTRELVAYCHERGIATEAEPGRIEGGEDGVADTAELEGLLTTPEESEEFVDTGIDWLAPAFGNVHGEYGPRGIQLEYERLKSINEKVGDRVRLVLHGADPFTEEIFRKCIECGVSKVNINKVLNNEYVKVQREKAGRVPLTQLLEEATDEMQKAVEKCMDMLGSTGRY
197
B5YKR8
4.2.1.11
ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00318, ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00318, ECO:0000256|PIRSR:PIRSR001400-1"
MGEIIDIIAREVLDSRGNPTVQVDIYLDSGVMGRATVPSGASTGTREALELRDGDKKRYFGKGVQKAIDNIINEIAPNIIGMESLDQEGIDRFLIELDGTENKSKLGANAILAVSMAVCKASAEEVGLPLYRYLGGTNAKVLPVPMMNIINGGIHADNNLDIQEFMIVPAGFVKFSQALRAGVEVFHSLKGILKKKRLNTAVGDEGGFSPMLEKNEDAIKLIIDAIKEAGYEPGKDIYIALDPAASEFFAEGFYTVEGKKIDSKDMVDYYEALVDKYPIISIEDGMSEADWEGWELISQRLKNKIQIVADDLVVTNPKIIKEAMKRGIANSILIKLNQIGTVSETLEAIELTKNNKYTAVVSHRSGETEDTIIADLSVSCNTGFIKTGSLSRGERIAKYNRLLQIEEELNDVAQFKGLSAFYNLGF
200
Q5XIJ5
3.1.2.22
ACT_SITE 190; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q96GS6"; ACT_SITE 255; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:O75608"; ACT_SITE 284; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:O75608"
MNGLSVSELCCLFCCPPCPGRIAAKLAFLPPEPTYSLVPEPEPGPGGAGAAPSGPLRTSAATPGRWKIHLTERADFQYGQRELDTIEVFVTKSARANRIACMYVRCVPGARYTVLFSHGNAVDLGQMCSFYVGLGTRIGCNIFSYDYSGYGISSGRPSEKNLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRVAFPDTKKTYCFDAFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDIELYSQYLERLRRFISQELPSQRT
134
A0A3B3I282
3.1.4.11
ACT_SITE 325; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 372; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"
MNKKRYFLDPPEVKDYLVKGERFTKWSEDSTKTVPVTMKMDPKGFYVYWMNQSKETTFLDVNTIRDTRTGKYAKLPKHPKVRNVFNLDFPDSNHLAKTLTIVSGPDMVNLTYHNFFASKDKVTQNWANDILAISYNAARNNACRQVFLEKIYVRISLQTNKDGKIPVKNIYKMFPADKKRVESALAAAHLPKGKYDSMKADVFTEAAFRTFMMNLCPRPEIYEIFTSYSTKPTMSKENFTKFLYEKQRDSRLNEELFPRLRQDQIKALIDKYEPISTNSNRGFISPEGLLFFLMGPETSVVMQDKLAKSQDMTQPLPHYFIKSSHNTYLTAGQFSGVSSPEMYRQCLLSGCRCLELDCWKGKPPDEEPIITHGFTMTTEILFKDVIEAIAESAFKTSKYPVILSFENHVDSVKQQEKMANYCKTLFGDALLTEPLDKYPLKPGQQIPSPSELMGKILIKNKKGSHEKPAQAKKSSTAATDQAAAATPQDPNCPSQDETNPTSPSQENQADGEGTVEENEEQEDTEEQDEEKMKTSDEGTAGQEVTAYEAMSSIVNYIQPNKFISFDNARKKNKSYVISSFVETKGEAMISKTAVEFVEYNKRQMSRIYPKGTRMDSSNYSPQPFWNVGCQMVALNYQTMDFPMQLNMALFEFNGRTGYLLKHDVLRRGDKKFDPFCDRIDTVVASTLTIKIYSGQFLSDKNVKTGVEVEVIGLPGDPKKKYRTKWSTTPNAINPVWNEEPFVFEKILLPELASLRIVVHEENGKFLGHRIIPVDAIQSGFHHICLRSESNMPLTLPALFVYIEVKDYIPAAFADFTDALFNPTKGTEKTTKTPKESSTDYISPYELPLVVQPPTDKVKESAAPAAEKLTSEKTPSTDAADQSAQAAHESSPGAADPPQPDPPSTPTEDAGGPSSEVPSEDASSPKKAVEEKEAAQEPVAVLDAQDQPDTQSEPVVEQVVSDSCRRSEEPASAEPKSEETTPPAEAAGAGDNSQTEPSTVTTEHLTQHKNYLKVIKRQEREMKEFEKKYQKKEEELMQKYSDVFKAVKKKVSLKKKEGDDDTSDSSVKASRVQEQREKMQAELQVLWTEQCDQLKKKKEQCATERLAKLMEMAMEKHTSELKALESETKEKKKTVSKCSSTEKPKLKKAMSTEVLDETSQSEGVQSSESFPQQEALMRKQEATLEEIKTLTNQLNQEAVKEHTQKLRSLPAEVKEAVNSCMGAHFPELVDKPGEKRVGEMGFYGDVFLG
153
Q55848
2.7.6.1
ACT_SITE 214; /evidence="ECO:0000255|HAMAP-Rule:MF_00583"
MSAVSRIATLTRQSMLSALSDNNRLRLFSGSSNPSLSQEVARYLGMDIGPMLRKRFADGELYIQIQESIRGGDVYLIQPCCHPVNDNLMELLIMIDACRRASARQITAVLPYYGYARADRKTAGRESISAKLVANLITGAGAQRVLAMDLHSAQIQGYFDIPCDHMYGSPVIIDYLKSKQLTDLVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQSHNVAEVLNLIGDVDGKTAVLVDDMIDTAGTLSEGSRLLRAQGARQVYACATHAVFSEPAINRLSGGLFEEVIVTNTIPVPDDHHFPQLTILSVANLIGEAIWRIHEESSVSSMFR
114
W1NKE2
3.1.1.11
ACT_SITE 413; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAEKLQWRRDRTLSLLFSTLLFFSLLTLTQATPPSPLEATTPNPPTPLSPNGSSPPLNPVTACKTSLYPKLCRSLLSPLKSSSLKDYGRFSIKRCMKETQKTAKVIDRFLTRRSSLRHVEAGALEDCRLLSDLNADYLTQIAGDLWSSDSISDTRVGRVNSLLSAIVTNQHTCYEGLEASSSRLQQLLGASLANGTKLYSISLDLVANAWKQKGRFPGQKPAIFPARDSFPIHKPAGFPAEKGFAAEKLRFPAKGLGMRDFVTVSKGKDGNFTSINEAVASAPNNTNVEEGYFVIYVKEGVYEEHVTVARNKKNLMVIGDGINRTVVTGNRSVVDGWTTFNSATFAVMGERFIAMDITICNTAGPEKHQAVALRNSADLSAFYRCSFQGYQDTLYTHSLRQFYRNCDVYGTVDFIFGNSAAVLQNCNLYARQPMPNQKIAFTAQGRTDPNQVSGLSIHNCTIKPSPELDKNSSFNEVYLGRPWKEYSRTVYMQSYIDGFVDPAGWLEWNGSFALDTLYYGEFMNRGPGSNTSRRVQWPGFDVMDAREAWNFTVLNFTMGDTWLPSSVVPFAGGLL
125
Q10SI9
1.11.1.7
ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MEARGSRGMRLWLLSVAVMAMAMATRSQAQLQVGYYDTLCPAAEIIVQEEVSKAVSGNPGMAAGLVRLHFHDCFVRGCDASVLLDSTQGNRAEKDAPPNTSLRGFEVIDSAKSRLETACFGVVSCADVLAFAARDALALVGGNAYQVPGGRRDGNVSVAQETNGNLPPPSANVAQLNQMFGAKGLTQAEMVALSGAHTIGVSHCSSFSNRLYSSGPNAGQDPSMDPSYVAALTTQCPQQQGQPAAGMVPMDAVTPNAFDTNYYAAIVANRGLLSSDQALLADQTTAAQVVGYTNNPDSFQTDFAAAMVKMGSIGVLTGNAGTIRTNCRVAS
14
F1MRH9
3.1.3.48
ACT_SITE 1065; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREITYFSLWYYNKQNQRRWVDLEKPLKKQLDKHALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGNIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALLPVEWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGVFVKHKSGRPPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYVWRLCVARHKFYRLNQCSLQTQTVIVNPVRRRSSSRMSLPKPQPYAMAAPPQLHYNGHYTEPYTSSLDNLFVTNQNGFYGHSQTSLDRAQVELGGRVRNGSVYSAHSTSSLNSPQPYLQPSPGSSNPSITGSDVLRPDYVPSHRHSALIPPSYRPTPDYETVMKQLQRGLAPAERQSRSLRNLSLVYSQPEIREHARPGSPPMAPCAFSLSHSFHSPAPYPYASAAGRRPGLGAVSVPELTNAQLQARDCPAPSILRTQVYRPPPPYPHPRPANSTPDLSRQPPISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARRARLQKRNSVELAGLAHGLEGLRLQERAAPALAAGERALRAEDCAAGLRGSLRGGHGKSLSDATVLIHSSDEDEDEDPEEGPAPPLGSRGGRPPDASHAAPLAPGPLHILEPQAPGAAPGEGPRPRRDGLLSPSASESDLTTSGRYRARRDSLQKRPASDLLSAKKNAVEGLPPLGGMKKSRGDAKKIGPLKLAALNGLSLSRLPLPDEEKDVPARATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDARVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCPDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLSGQERTIWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSASEPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEALDVPRVLDMLRRQRMLMVQTLCQYTFVYRVLIQFLRSSRLI
149
Q8Y417
2.2.1.1
ACT_SITE 410; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
MKKTLDRQAVDTIRSLSIDMIEKANSGHPGMPMGAAPMAYMLFAKHLVFNPANPEWFNRDRFVLSAGHGSALLYSMLHLFGYDVKMEDLKQFRQLDSLTPGHPEFGWTAGVDATSGPLGQGIGMAAGMALAESHLAAEYNQPNYPIVDHYTYAICGDGDLMEGVASETASLAGHLGLGKLIVLYDSNDICLDGDLSATFSENAADRFRAYGWQVLRVEDGNNLAAIQEKIVQAKLETSKPTLIEVKTVIGYGAPTKAGSSASHGAPLGEKEANGAKEHYEWAEEPFTVPAEVRDYLRNYKARGEKLEGAWNTMLANYKKEFPELARQLDRVLAGEVAADWNANLPTFEAGTNVATRSASGKMINAIAAELPELFGGSADLGCSNKTFIDASPAYSIQDPAGKNIWFGVREFAMGAMLNGMALHSGLRVFGSTFFVFSDYVRPAMRMAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQLASLRAMPGLTVIRPADAKETRAAWEIAATNTNGPIALVLSRQDLPVLENDQEEVDAGIEKGAYIVAPANSSKPDAIIIATGSEVSLAIEAKAELAKKDIDVSVVSLSSWERFEKTTDAYKESILPKEVTARFAIEAGATFGWKEFIGSEGDMLGIDHFGASAPAKDLFNAYGFTPENVADRVEAVIAKAGVRV
51
O16581
3.2.1.45
ACT_SITE 254; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 358; /note="Nucleophile"; /evidence="ECO:0000250"
MSIAWSCFVLGLFALASLQVALANDCAQKTFKTGIVCVCNITYCDEIPDINLLSGQAATFTTSKSGARLHRDVVYATNSDPLTSMHFTIDSSKTYQTIQGFGSTFSDASGANLKSLPDQMADTILRQYFSDSGLNLQFGRVPIASNDFSSRVYTYDDNLEDYNMAHFSLQREDYQWKIPYMQMAQKYNHDLKFFAVPWSAPGWLKTTNSTKGYGILLGTNQDTYHKSYVTYILHFLEEYQKNGILFWGLSTQNEPTSGSDKKTKMQSMGFTAEFQRDFIKLDIGPALKSSNAGKNVKILILDDNRGNLPKWADTVLNDKDAASYVSGIAVHSYQDDESDKHLTQTHNNHPDVFIFGTEASEGSKSKDVDYGSFDRAEDYVSDILDDFNNWVTGWTERNLVLDAQGGPSWVSGFADAPVIAFPALAQFYKQPMFYAIAHFSHFLKPGAVRIDHSLNMPNPEIERSAFLNPDGSKVVVLHNKNPLAPYSLSIKDTMKSTDHYQVHLSPKTIVTLYIQN
168
Q11GB4
1.3.3.3
ACT_SITE 131; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333"
MEQPHIPAGLPEDVENKKEAARAWFETLRDKICAALEGLEDELSGPHSSYAPGRFEQTPWLRQEGAGGGGVMSIMHGRVFEKVGVHTSTVHGEFSPEFRRQIPGAEEDPRFWASGISVIAHPQNPHVPTVHMNTRMVVTTRQWFGGGADLTPMLNRRRSQEDPDAIAFHKAMRFVCERHAAVADYEKFKNWCEEYFFLPHRNEPRGIGGIFYDWLKSPEENGGWDADFAFTQDVGRAFVMVYQHIVRKNFNTNWTEADREEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVNSILSSLPPVVKWP
27
Q9H3S7
3.1.3.48
ACT_SITE 1392; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044"
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQLMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQAGAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPSDDPLSLLDPLWTLNKT
149
B6JW74
3.4.19.12
ACT_SITE 306; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 717; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"
MTCPHFTEEYAHCPPTGTVIYQEECVRCFISTDSSSGIDLCLCCFESGCTKNDLSHNVSHFDLTKHPIYLNIRRTPKDQEEPPQKLTKLEIKEENEADKFQFYYNAHCIVCDVAIDQENEKVKAIVDALKKSPSASQMSQVKSWENEIVPCEHVLTLQQTPAYTVSVNGSCTQCELSENLWLCLNCGKLSCGRKQFGGGGGNGHAVEHFQSTNHGVAVKLHSLSASSQPDVYCYICDEERDDPEIKNHLSTFGLNLDSMSKTEKSLAEMQLAQNLNFDFGSMEEEEGAKKLFGPCLTGLRNLGNSCYLSSVVQALFSIDVFRNHYLQVFQTHNAKCSSATTCLVCQLGKLADGLCSGKFSRPSHFVMASEDPSKIPFQDGLRPFMLKDIVGKGHEEFSTGRQQDAYEFLLYLLKKVKTAKDESGLDMSSMVSFTTEQRLQCLGCNRARYSKIETESLALPIVKRNNGESFFEDCLRSFVSQDQMEYTCESCHSKAGAVTQTRFVSFPKVLAVQLNRFDIVNWELKKVNTAVQLGGDAIYDLSDFLVGPRQEGEELLPEESKSQVEWNELAMEQLTAMGFSVNRCQHALLATGNSDAESAMNWLFEHLEDPSIDEPVDLSKISEPSSTEVSSDHVSSLCDMGFTVKAAKHALKETQNNVERAVDWLFSHTDDLAAIENATEGATDQNSINVFASTTVPALYKLKAIVCHKGGSVHAGHYVAFIRELVDGQDVWALFNDEKVLQVSSLKETESTSYVYILERLDA
175
Q6CFS5
2.7.11.1
ACT_SITE 330; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MTDKWVPGQGQPMYGSQQPHNLMPPPSGLYQQNSNQSNTSLDQQQQFNQQQYNSQQQYQQQQHSQYQQQQQQHQQQQQQQQQQQQQQQQQQQQQQQQHQQHQQQQQQPQQQSVAQQQPSDYVNFTPRPDLLSKTARDRAHNTTQVISTYYKGIVQHAIERHQRRSAAEASVEQATSEERRNRVLTNYGKKETAYLRMRRTRMALEDFVTVKVIGKGAFGEVRLVQKRDNGKIYAMKTMLKKEMDMKEQWAHVKAERDVLADSDSPWIVSLYFSFQDDLYLYLIMEFLPGGDLMTMLIKYDVFSEDITRFYIAECVLAIEAIHKLGFIHRDIKPDNILIDKTGHIKLSDFGLSTGFHKTHSSAYWKKLKDGTSSNPATQMGPPQNTNRQSTYDSIHLTMRQQISTWRKNRRLMAYSTVGTPDYIAPEIFVHQGYGQECDWWSLGAIMFECLVGWPPFCSEQPRETYHKIINWRETLQFPDDVHLSPESEDLIRRLLTSSENRLGRIGGANEIKSHPFFRGVDWSSIREFNAPFVPKLSSITDTSYFPTDELGDVSEYPQQSSRSDRSSDLPFIGYTFSRFDNMTRRNAI
99
A0A0D1CKM8
2.4.1.18
ACT_SITE 357; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 412; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MAAATTSAAAQAPAPIDYSKATDGTGVIALDPWLEPFAPALRERYGVYADWVKRINASEGGLEAFSRSYRKMGFQIDPTTQAVTYTEWAPNAVQASLVGDFNNWSRDAHPMSKDDFGKWHITIPPLAKGQCAIPHDSKIKVSFVLPSGERIERLPAWILRVTQDLNVSPVYDARFWNPAKQDRYTMRFPKPPKPDNIKVYEAHVGIATPEARVGQFKEFTKNVLPRIKELGYNTIQLMAIQEHAYYASFGYQVTNFFAASSRYGNPEDLKELIDVAHSLGITVLLDIVHSHACKNVLDGLNMFDGTDHLYFHEGGKGRHELWDSRLFNYGHHEVLRFLLSNCLFWMEEYGFDGFRFDGVTSMLYTHHGIGTGFSGGYHEYFGPSVDVEAVVYLMLANQMIHEYNPKAITIAEDVSGMPALCRPVSEGGVGFDYRLSMAVPDMWIKLLKETSDEDWDFGNICFTLTNRRHLEKSIAYAESHDQALVGDKTLAFWLMDKEMYTNMSDLTERTQVIDRGLALHKMIRLITHALGGEGYLNFIGNEFGHPEWLDFPREGNGNSFHYARRQFNLVDDQLLRYKYLYAFDAAMNKAEEKYKWLAAPQAYISLKHDSDRVVAFERAGLLFVFNWHADKSYTDYRIGVDVPGKYRVLLDTDQASLGGHARLDHATEYFSTDMAWNGRSNFVQLYLPSRSAIVLYRAG
73
W1NJS8
1.11.1.7
ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MALIVIVNLLMLSSVASLVNSLSVNYYDRTCPNAESAVTDAVKKAVLNDKTVPAALLRMHFHDCFIRGCDGSVLLESGKGNTAEKDGPPNVSLHGFYVIHNAKKAVEAICPGVVSCADILALAARDAVTLSGGPSWNVPKGRKDGRVFKATETRSLPAPTFNLSQLIQSFSQRGLSQQDLVALSGGHTLGFSHCSSFENRIHNFDASHDVDPSLNPSFASKLKNICPAHNKVKGAGSTMDSTSTAFDNSYYKLLVQGKSLFSSDQSLLSSPQTKALVAKFASSKKAFEDAFINSMIKMSSLNGGQEVRLDCRFVR
14
A0A9R0K4H0
2.1.1.37
ACT_SITE 511; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MATRKSARKKPSSPSSSPASASASASASASASLKSKRRKVEVKDEEIVNNGGTESTEMSLTVEGEEIADEEIVESPAGSGRKNTRKIVKKEETDCRFLGDPVSADEAKLRWPHRYPDKAEQGTKKPKTSQDDDDELILAKCHYLKAEVDGTKIFDLNDDAHVQSEEGKLPYICKIVEMFEGVDGFLYFRAQWYYRSVDTVIKESITLKETKRVFASEVMDDNPLDCLVEKLNIVRVALDLDIDSKMSAIPDCDYYYDLKYLLPYSSYIVPPPETTSPIGSESQSTISNDIEVDGAVADKKSDSAEVNQGKKAHNPETTLLDLYCGCGAMSTGLCLGANLCGTNLVTRWAVDFNENACQSVALNHPETNVRNESVGDFLKLLKEWPKICASFGLIKSENTNEKIDAMVVEDDEDDDGAENDSGKDDNKDDGEIFEVEKVIGICYGDPTKSGTPELHFKVRWKGYGEEEDTWEPLEGLSNCREKIGEFVKEGYKAKILPFPGDVDVVCGGPPCQGISGFNRFRNTENPLADPKNEQLVVYMDVVDYLKPKYALMENVVDLIKFSKGFLGRYALGRLVDMNYQARMGMMAAGAYGLPQFRMRVFIWGARPSEKLPQYPLPTHDLVLRGVIPTEFEMNTVAFNEGHTVQLEDKLFLGDAISDMPEITNDENRDEMPYSRPPETEFQRFIRMTKEAMLGSSNSSEMITKLYDHRPLRLNTDDFQRVCRIPKKKGANYRDLPGVLVGPDNKAKRDPDVEKELLPSKKPLVPEYALSFVGGTSSKPFARLWWDETVPTVVTRAEPHNQAILHPLQDRVLSIRENARLQGFPDYYKLVGDIKARYIQVGNAVAVPVARALGYALSVALTSDCDLDGPLLTLPARFPNLQEIPSSPSVEDNS
47
T1FNW6
4.1.1.50
ACT_SITE 92; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 106; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 250; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 264; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MKNIEPGSHCTISVVEDPLHEGEYFFEGTEKLLEIWFSPSSPSSASGSVQGGRASLRDINRSEWELLLKNVNCEILSSRHSTTMDAYLLSESSMFVSKDRIILKTCGKTTLLEAVKPLLGLAKEQCGFDNIVDVFYSHKNYLRPDLQPETYRHFDQEVAMLDTLFEDGAAYVLGKLNKDCWYIYTLDRFNITEPDQTLEIMMMDVNQDVMNMFTQSYGLTASQLTEKTGILDILPGAIIDDWLFEPCGYSMNALLPNGRYFTIHITPEDEFSYVSFETNVPRDSYNDLITKVTDIFQPNKFIVTLMANEASPAYKLCLKMDGPVKPFRRTEHQACEMKNYNLNYALYERPPTSKLIPYK
196
P0DH86
2.7.11.1
ACT_SITE 650; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MRGELPNKHHSYTFFVFLFFFLILFPDLSISVNTLSATESLTISSNKTIVSPGGVFELGFFRILGDSWYLGIWYKKISQRTYVWVANRDTPLSNPIGILKISNANLVILDNSDTHVWSTNLTGAVRSSVVAELLDNGNFVLRGSKINESDEFLWQSFDFPTDTLLPQMKLGRDHKRGLNRFVTSWKSSFDPSSGSFMFKLETLGLPEFFGFTSFLEVYRSGPWDGLRFSGILEMQQWDDIIYNFTENREEVAYTFRVTDHNSYSRLTINTVGRLEGFMWEPTQQEWNMFWFMPKDTCDLYGICGPYAYCDMSTSPTCNCIKGFQPLSPQDWASGDVTGRCRRKTQLTCGEDRFFRLMNMKIPATTAAIVDKRIGLKECEEKCKTHCNCTAYANSDIRNGGSGCIIWIGEFRDIRNYAADGQDLFVRLAAAEFGERRTIRGKIIGLIIGISLMLVLSFIIYCFWKKKQKRARATAAPIGYRDRIQELIITNGVVMSSGRRLLGEEEDLELPLTEFETVVMATENFSDSNILGRGGFGIVYKGRLLDGQEIAVKRLSEMSSQGTNEFKNEVRLIARLQHINLVRLLSCCIYADEKILIYEYLENGSLDSHLFETTQSSNKLNWQTRFSIINGIARGLLYLHQDSRFKIIHRDLKASNVLLDKNMTPKISDFGMARIFERDETEANTRKVVGTYGYMSPEYAMEGIFSVKSDVFSFGVLVLEIVSGKRNRGFHNSGQDNNLLGYTWENWKEGKGLEIVDSIIVDSSSSMSLFQPHEVLRCIQIGLLCVQERAEDRPKMSSVVLMLGSEKGEIPQPKRPGYCVGRSSLDTADSSSSTKRDSESLTVNQITVSVINAR
99
A0A0R4ITP2
3.4.19.12
ACT_SITE 14; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 119; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 119; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 134; /evidence="ECO:0000256|PIRSR:PIRSR633865-1, ECO:0000256|PROSITE-ProRule:PRU00331"
MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAQQLDEEERMRMAEGGVQTEEYRTFLQQPSGNMDDSGFFSIQVISNALGVWGLEIVLFNSREYQQLQMDPMHEKAFICNYKEHWFTVRKLGQQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVIRGNLPECEADQILRIMRVEQQQRPKLIGEEEAQRMSAPHASETTHTAEEPVLDEDEEELRKALALSRQDLQVEDEEADLRRAIQMSMQGSSDAGSSAPAGGSSEKQTLSAEELRRRRQAYFDRQQNAQDSSSSTGGGTDSGPKPTQ
175
D6WVS3
1.3.5.1
ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
MSGLLKIQTIFPKHILTNVAKNPKVLAQGLHIGVDKKNAKVSSDAVSKVYPIVDHTYDAVVVGAGGAGLRAAFGLVAEGFKTAVVTKLFPTRSHTVAAQGGINAALGNMEEDNWQWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELENYGMPFSRTSEGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGQSLRYDCNYFIEYFALDLIMEDGECRGVIALCLEDGTIHRIRAKNTVLATGGYGRAFFSCTSAHTCTGDGTAMVARAGLPSQDLEFIQFHPTGIYGAGCLITEGCRGEGGYLINSQGERFMERYAPVAKDLASRDVVSRSMTIEIREGRGCGPEKDHVYLQLHHLPAEQLHTRLPGISETAMIFAGVDVTREPIPVLPTVHYNMGGIPTNYKGQVLTNVNNQDKVVKGLYACGEAASSSVHGANRLGANSLLDLVVFGRACAKTIAEEHKPGEKIGDIRENAGEASVANLDWCRYAKGAIPTATLRLQMQKTMQTHAAVFRTEETLQEGCKLMEGLYSNLKDLQVTDSSLIWNSDLVETLELQNLMLNACQTIVAAENRKESRGAHAREDYKLRIDEYDYSKPVEGQQKKPLEQHWRKHTLTTIDEKTGKVSIRYRPVIDDTLNKNECSTVPPAIRSY
28