Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q815E7 | 4.1.1.50 | ACT_SITE 65; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000255|HAMAP-Rule:MF_00464"; ACT_SITE 70; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00464"; ACT_SITE 85; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000255|HAMAP... | MEYSTFGKHIIVDLWGVDFSLLDDMHFLEYHLVTAADYSGAHVLNVSKKEFQPYGVTVLVLLSESHLSIHTYPEQNFAAIDCYTCGTTVEPQIAIDYIVNILKPERMHIKRLIRGIGEIVTAD | 196 |
A0A2R6X3F9 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASASLRWVVFTTLVFFFVRDCSGQLVTGFYNATCPNLTSIISSRLNILLAADVGLAAGLLRLHFHDCWVRGCDGSVLLNSTNGNVAEKDSTPNANSLIGFAEIDTIKSDVEAACPGVVSCADILALAAEDATSKVGNVSWPVPTGRRDGTVSIASEAVTNLPPPSFNFAQLVQNFATFGLDTKDMVVLSGAHTIGRTRCLHVTQRLWNFTGVFNTTDPSINATFVDFLKGVCPSNAGTRQFVSLDSTGQTFDSIFYNNILALKGVLGSDSELINNAQGLQIINTMLANISFAADFGVSMVKLGNVQVKTGTVGEIRKNC... | 14 |
Q8ZX33 | 4.1.1.50 | ACT_SITE 71; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000255|HAMAP-Rule:MF_00464"; ACT_SITE 76; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00464"; ACT_SITE 91; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000255|HAMAP... | MAGGVGGRVVVGRHVYGNLYGCDSRVLRDEAALITIVKEAVKVANAMLLSIGSYRFGPGGGLTVFAVVAESHISIHTWPEHGFATVDVYTCGDHTDPKAAFDYIVSQLRPKRVEVFFGDRSMYGE | 196 |
Q563W7 | 2.7.11.1 | ACT_SITE 1676; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR629601-1" | MSQKSWIEHTFTRRECVYILPVSKDPHRCLPGCQICQQLVRCCCGRLVRQHVGFTATLAVKYSEVSEELSELEQWSVEKHTEESPTDAYGVINFQGGSHSYRAKYVRLSHDSRPEAVLRLMLKEWLMELPKIVISVHGGIQNFELHPRIKQVVGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHLSRSARKICTVGIAPWGVIENRNDLIGRDVVAPYQTLLNPLSKLNVLNNFHSHFLLVDDGTVGKYGAEVRLRRELEKHIQLQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAAD... | 99 |
K7L3Y8 | 2.3.2.26 | ACT_SITE 833; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSVIDTPAVHHRSGGATDHRHPSKRKFDDEDDEDFSDLVCVRMRKDEAKAVNSWSASSSSSSSDAGGCSSLQQQQRSHIQFFVRMMSAGNTIVMQAFPEDTVKSIHERIQSMKGIPLFEQRLIYRGKQLQWEQTLAECFIQNDANLQLVGRMRSTEHPQAWQVINDMVSLVYRLCRGETVHDALKTVKGLMTSYLNMTPRIDNDSASGYFQIFMSSSAPAVLVMLYVSPYAGNKDCADSSVRHFLSSCRNILSKALHGQCARVVLEFCKLLRRVGSHDPLYLFCRSTFGSLLETAGVSYGSGSDNVKGLVLIQDIFPFVC... | 65 |
P58072 | 1.2.1.12 | ACT_SITE 150; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P0A9B2" | MSKVGINGFGRIGRLVLRRLLEVKSNIDVVAINDLTSPKILAYLLKHDSNYGPFPWSVDFTEDSLIVDGKSIAVYAEKEAKNIPWKAKGAEIIVECTGFYTSAEKSQAHLDAGAKKVLISAPAGEMKTIVYKVNDDTLDGNDTIVSVASCTTNCLAPMAKALHDSFGIEVGTMTTIHAYTGTQSLVDGPRGKDLRASRAAAENIIPHTTGAAKAIGLVIPELSGKLKGHAQRVPVKTGSVTELVSILGKKVTAEEVNNALKQATTNNESFGYTDEEIVSSDIIGSHFGSVFDATQTEITAVGDLQLVKTVAWYDNEYGFV... | 22 |
I1KJ59 | 5.1.3.3 | ACT_SITE 183; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 315; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAACKSSSAISAAPSSPYPYPEKMVLFRFIFISIQCYLLIYDMLSLFFQGLLSDIVLGLESVESYQKGLAPYFGCIVGRVANRIKDGKFTLDGIQYSLPINKPPNSLHGGNVGFDKKVWEVVEYKKGNTPSITFRCHSHDGEEGYPGDVTVTATYTLTSSTTLRLDMEGVPKDKPTIVNLAQHTYWNLAGHNSGNILDHSIQLWANHITPVDENTVPTGKIMPVKGTPFDFTSENRIGNTISQVGLGYDHNYVLDCGEEKEGLRHAAKVRDPSSSRVLNLWTNAPGVQFYTANYVNGVQGKGGAIYGKHAGLCLETQGFP... | 211 |
D4GYZ1 | 3.4.25.1 | ACT_SITE 50; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113" | MRTPTHDEFSGRLDSLNGDRSNVFGPELGEFSNADRRADELGDKETKTGTTTVGIKTEEGVVLATDMRASMGYMVSSKDVQKVEEIHPTGALTIAGSVSAAQSLISSLRAEVRLYEARRGEDMSMQALSTLVGNFLRSGGFYVVQPILGGVDETGPHIYSIDPAGSILEEEYTVTGSGSQYALGVLEQEFEDGLSIEEAKGVATKAIRSAVERDLASGNGINIAVVTEDGVDIQRHQNFEGLE | 180 |
P42521 | 1.17.4.1 | ACT_SITE 119; /evidence="ECO:0000255|PROSITE-ProRule:PRU10014" | MEEINKKDTFIEPILKENKDRFVLFPIKYPDIWRMYKKALASHWVAEEIDLGNDNVDWEYKLTDNERHFISHVLAFFAASDGIVNENLATRFMSEVQIPEARCFYGFQIAIENIHSETYSLLIETYIKDKQTKDKLFNAIETIPCIKKKAEWALRWINDSDSFAERLVAFAAVEGIFFSGSFCSIFWLKKRGLMQGLTFSNELISRDEGLHCDFACLLYTKLQRKLDPKVIEKMIRDAVECEKEFICESLPVDLIGMNSRSMSQYIEFCADRLVVSLGYKKIFNSSNPFEWMEMISLQRKSNFFEGKVAEYAKTGVAIQG... | 21 |
Q6C8T8 | 3.5.4.5 | ACT_SITE 60; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MSITKSELENLRDKSLSARDFSYSPYSKFRVGAVLLTESGEWIQGANVENASYGGAICAERVAITRAIMEGHKKFKAIGVASDLSVVCSPCGICRQFIREWSTDIPIYLFTKDGKYTMQTIKELLPLSFGPEHLDTEKVEAETETLLEV | 187 |
Q8A6B4 | 1.11.1.6 | ACT_SITE 54; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 127; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MEEKKLTAANGRPIADNQNSQTAGQRGPVMLQDPWLIEKLAHFDREVIPERRMHAKGSGAFGTFTVTHDITKYTRAAIFSEVGKQTECFVRFSTVAGERGAADAERDIRGFAMKFYTEEGNWDLVGNNTPVFFLRDPLKFPDLNHAIKRDPKTNMRSPNSNWDFWTLLPEALHQVTITMSPRGIPYSYRHMHGFGSHTYSFINADNQRIWVKFHLRTLQGIKNLTDQEAEAIIAKDRESHQRDLFESIEKGDYPKWLFQIQLMTEEEADHYRINPFDLTKVWPHKDFPLQDVGILELNRNPENYFAEVEQAAFNPINTVD... | 13 |
P93680 | 3.2.1.14 | ACT_SITE 140; /note="Proton donor"; /evidence="ECO:0000255|PIRSR:PIRSR001060-1" | MVYCTASLPLLLLLLVGLLAGEAFAEQCGRQAGGALCPGGLCCSQFGWCGSTSDYCGPTCQSQCGGVTPSPGGGVASLISQSVFNQMLKHRNDAACQAKGFYTYNAFIAAANSFNGFASVGDTATRKREIAAFLAQTSHETTGGWATAPDGPYAWGYCFLKEQGNPPDYCVPTAQWPCAPGKKYYGRGPIQISYNYNYGPAGRAIGYDLINNPDAVATDPVISFKTALWFWMTPQSPKPSCHNVITGRWTPSAADRAAGRLPGYGVITNIINGGIECGKGFNDKVADRIGFYKRYCDLLGVSYGSNLDCYNQRSFGVSTN... | 158 |
A9VB82 | 3.1.3.48 | ACT_SITE 492; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 494; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MAGAPGAMVDLHAIFNDITKSQHRIEAACRGIQQAEAQFSDNLLHELFQTLAKGDEARNIACCYLLDYVFANADGPFCQALRQNMPILYGLALPDKPAFKSHNKLKKLYDRWVKKNWIPEAEAALTDMAPAVAYRRTQKLLHSTPTSIAHARVVANEVPVTSPEHPTTLQLRNLYRNRNTIQSPNPNPSNPSNLGNPSNKRSHNKRTALPNFLWRPLTLAGDWLTLERTVSDDWYEGTNLRTGARGIYPVAYVEQTQLAPPPQAPPAHHPPAGFGAPFPPPGVWAAGAPGHAGPPANANFPPPHNAGTNYPPPTNAGFQP... | 149 |
Q6Z829 | 2.7.10.2 | ACT_SITE 387; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLRTKTPRPRGGKSRRATAAAGKEREREREREREGRSPSGELSLQLEHVSLFSFLADAPREGAAAARTPFTPFEELLEGSCDPDPTPPPPLPPLQPQATPMDADEVVEEKDSGILSQDFFCTPDYITPDAPQLGSGFDANKENIPCPNSPEKSVCRSKRYKRDCSPKGLGSNDIFDSQWIAPVQFEGLDDSEEEQLKESSSHKRGSYVSQSAVALRCRVMPPPCIRNPYLNTDHQIDDNVFGGRQCKSSGFSPSVDGDGLSRYRTDFHEIEQIGRGNFSVVFKVLKRIDGCLYAVKRSIRQLHNDRERRQAVKEVQALAA... | 98 |
P43867 | 3.4.21.92 | ACT_SITE 98; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 123; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MSVIPMVVEQTSRGERSYDIYSRLLKERVIFLSGEVEDRMANLIVAQLLFLESEDPTKDINIYINSPGGSVTAGMAIYDTMQFIKPDIRTLCIGQACSMGAFLLAGGTAGKRAALPNARVMIHQPLGGFRGQASDIQIHAQEILKIKHTLNDRLAFHTGQGIERIEKDTDRDNFMSAEEAQAYGLVDEVLVKR | 179 |
A0A2K1R4Z5 | 3.1.1.11 | ACT_SITE 410; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTQAGQYTSMSKKNKRLVLAIFASFLLVATIIAIAIGVNSHKNSTKNDAAHALLMASCNSTRYPDLCYSAATSFPDASGGDPKAVILNNINATIDAINSKKIKANSILSTKDLTEQQKTALKDCRQNYDSSLADLEKVWGALTRNPNNQLLQQQSYADQLTTQVTSCKTNEDSCLDGFSHKSLLRELREWFHDPSKDDAGNMCSNTLALIKKLIENTKAIANRLKTTSRKLKEEDDSAEGWPEWLSVTDRRLFQSSLLTPDVVVAADGSGKYRTVSAAVAAAPKHSAKRYIIKIKAGVYRENVEVPSEKTNIMFLGDGRK... | 125 |
A0A9R1VUS6 | 2.3.2.26 | ACT_SITE 1832; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | METRSRKRAEATSSAHSSSSSGGPFTRSNKRTRLSTTTSSSASAAAASNVVVQSVSTRSRATNMENSTNESSGSGSGRGRRNRKSTNNQNMVSDRDNSEKGKEKEHEVRVKDRDNINRDSPYGLNIDMSADGGDDDDDDSEGGGVGILHQNLTSASSALQGLLRKLGAGLDDLLPSSAMASASSSHQSGRLKKILSGLRADGEEGKQVEALTQLCDMLAIGTEDSLSTFSVDSFVPVLVGLLNHESNPDIMLLAARALTHLCDVLPSSCAAVVHYGAVSCFVARLLTIEYMDLAEQSLQALKKISQEHPTACLRAGALMA... | 65 |
A0A5F8A332 | 2.3.2.23 | ACT_SITE 163; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133" | MCVCVCVCVCVCVCVCVKITIGPLRQVQELSGPRPSAHPARSAFLNSPSSPASGSLALWLSLLRPLTRPEGRRRHPPPTMALKRIHKELNDLAWDLPAQCSAGLVGEDMFHWQVTIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIAWIYKTDREKYNRIAREWTQKYAM | 64 |
Q5J1R9 | 2.7.10.1 | ACT_SITE 797; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MKVPKNTPLVVFLAFFSLTEGLQRAPRITTLLETVDSSLDHNATFICEVDSYPQADIIWTRNNYPIRYYDSRYVIQENGQMLIIPNVKDSDSGEYCCIANNGVGEAKSCGALQLKMKPQIKRHPTNMTLILESKAVLPCLSLGYPKPEISWIKEDDLIKANNRIAILESGSLKITNIKKEDAGQYRCVARNSFGIAFSRPVTIEVQAPAKILKVPKEKRVQIGSEVTLECNATGNPIPSITWLENGNTISGASVVETLVGEVILSVLQVVVHKPALYTCQATNRHSGGENTVKATAKITVSEWRLYKGHAGYCSTYRGDV... | 97 |
A0A0K9NSY1 | 3.4.21.92 | ACT_SITE 190; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 215; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MANSVVAMTAASNAAISSYATPFQRLGSKQHHCSTTHLPFPLHLRKSKRLVSSFGVPKAIYSGGSLGLDNSFRKGIWSVRDDLVMPSSPFFPVDAQAGQGPPPLVQEKLQSVISQLFQHRIIRCGGAVDDDMANIIVGQLLYLDAIDSNKDIIMYVNSPGGSVTAGMAIFDTMRHIRPDVSTVCVGLAASMGAFLLSAGTKGKRYSLPNSRIMIHQPLGGAQGGQTDIDIQANEMLHHKANLNGYLAYHTGQSLEKINQDTDRDFFMSAKEAKEYGLIDGVIMNPLKSLQPLPSTSEA | 179 |
A0A059AU94 | 3.1.1.11 | ACT_SITE 153; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | WHIRVDPSGQSGTFTTVQSAIDAVPENNNHWFCIYVKEGTYREKVQIPKNKPFIILKGRGKRKTEIVWDDHETVAQSPTFTSSADNIVVKSISFRNSYNNPVNENPKVPAAAAMILGDKSYFYRVGFSGLQDTLWDVEGRHYFKRCTIQGAVDFIFGGGQSIYEGCAISVLGNALPGLSGFITAQGRENEQDTDGFVFKNCNVFGSGSAKLGRPWRGYARVLFYHSNFTDVVDPKGWDAWSFVGREYQLTFVEYGCYGPGADMSKRVSWERKLDDSSVQQMTSLSYVDSEGWIDRTPF | 125 |
G1KI33 | 3.2.1.35 | ACT_SITE 136; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MQGGTVLAAAWLMFLAVAGALAGQKPAFTPIFTRRPFIVAWNVPSQDCQPRFKVQLDFSIFDLQASPNEGFVDQNLTIFYKERLGLYPYYNAQKVAVNGGVPQNSSLEEHLARLAVSISRYIRSEIKEGLAVIDWEEWRPIWIRNWQPKDIYRIASRQLVLSRHVELSEDQVKKKAQYEFESSASSFMKETLRVAKSFRPQQLWGYYLFPDCYNHDYSKNLDSYTGHCPDVEKTRNDHLAWLWKESTALYPSIYLEEVLANSINGRKFVRSRVQEALRISRQHHDDYDLPVFVYTRPTYNRRQNLTYLSEMDLISTIGES... | 166 |
G3GTP0 | 6.5.1.1 | ACT_SITE 273; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10135" | MATSQTSQTVAAHVPFADLCSTLERIQKSKERAEKIRHFKEFLDSWRKFHDALHKNKKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPREGKDALKLLNYRTPSGARTDAGDFAVIAYFVLKPRCLQKGSLTIQQVNELLDLVASNNSGKRKDLVKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTILNIFHNDAVELHNVTTDLEKVCRQLHDPAVGLSDISITLFSAFKPMLAAVADVERVEKDMKQQSFYIETKLDGERMQMHKDGSVYQYFSRNGYNYTDQFGASPQEGTLTPFIHDAFR... | 254 |
B4GAM2 | 3.4.19.12 | ACT_SITE 130; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393"; ACT_SITE 212; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393" | MNVAAGGPGTASASTTAANSIFNNSLLASATGATTMPMAQLADGWLELESDPGLFTLLLEDFGCHDVQVEEVYDLQKPIESPYGFIFLFRWIEERRARRKIVETTAEIFVKDEEAISSIFFAQQVVPNSCATHALLSVLLNCNENNLQLGDTLSRLKVHTKGMSPENKGLAIGNTPELACAHNSHAIPQARRRLERTGAGVASCRFTGEAFHFVSFVPISGQLFELDGLKPYPMNHGGWEDHEDWTDKFRRVMAERLGIATGEQDIRFNLMAVVPDRRIAITHKLKMLRTNQAIVSGTLQKLLKADEQGESGNGDQQRPD... | 175 |
Q8A4Y8 | 3.2.1.52 | ACT_SITE 283; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MVRKKGTLSIERLESIHFPDEWKNTGNLLVSDLKELANLSVMVNASNPSIHVKKVKMQEPEMYMLEITKQGIIIEAGDQTGMIHAFSTLLQLILGSEGKELPRFIIHDKPRFSYRGVMIDCSRHFWTIEQLKKYTKQLAFFKLNTLHLHLTDNQGWRLYLDQYPDLAFKGTYYRTFEDLSGHYYRKSELQELINYAAMYGIEIIPEIDLPGHCLALLAALPQLSCKGGKFEAYPEELDGQKRKRADENMLCIGNPETYRFVEKLVAELTDLFPSSFIHLGGDEVSTHLWEQCPKCQKIYKQENMTSWHELQDYFTKRVSE... | 170 |
A7T255 | 6.3.4.4 | ACT_SITE 32; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 60; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 161; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MFAVANGPTSSPRAAIGPKTKVTVVLGAQWGDEGKGKLVDILATNADVVCRCQGGNNAGHTVVVGDKHYALHMLPSLSGRDKQPANFCPGRNGVVIHIPQFFEELEKLEAKGIPEWKDRLIISERAHLVFDLHQEADKLKESGKTSLGTTKKGIGPAYASKVLRWLCLLYTAMSEASLMEHHFLYQNLFATPCPPILSVVLTIFFPLQELGNQMQEIGREFGVTTGRRRRCGWLDLVMIKYSHMINGFTALAIAKLDVLDTFEEVKLGVAYRYKGELLSSYPASLEVLSKVEVEYLTLPGWKMSITNCRSFDDLPQNAQV... | 253 |
P39009 | 2.7.11.1 | ACT_SITE 328; /note="Proton acceptor" | MSLSTKREHSGDVTDSSFKRQQRSNKPSSEYTCLGHLVNLIPGKEQKVEITNRNVTTIGRSRSCDVILSEPDISTFHAEFHLLQMDVDNFQRNLINVIDKSRNGTFINGNRLVKKDYILKNGDRIVFGKSCSFLFKYASSSSTDIENDDEKVSSESRSYKNDDEVFKKPQISATSSQNATTSAAIRKLNKTRPVSFFDKYLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLH... | 99 |
Q7Q039 | 3.4.19.12 | ACT_SITE 335; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 795; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MDTLRKYLAQVKVPCASDNVYKEECVYSFDNPETDTGLYVSLASFLGFGEQYVRPYAERTGNRVFLHLKRDKIEIPDPSAADGAGGADGPEKKITRLAIGVEGGYTGAESKKYEYQEHYQVVVFDEPVVRLDYPNVDLPLQVQNAVEAVQKAEAASVKREREQMAGTWDGEIRQVSTHAAELLQLDNGKKIPPTGWKCEKCDLTSNLWLNLTDGSIMCGRKFFDGSGGNDHAVNHYKETNYPLAVKLGTITADGKGDVYSYSEDDMVEDPYLVKHLAHWGINVGQLEKTEKSMIELELDLNQRIGEWGILCESGSQLKPI... | 175 |
Q7XKV5 | 3.2.1.21 | ACT_SITE 203; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"; ACT_SITE 417; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0" | MAVAGAMVMSGALLLLHLLAFTCVACNGGSELPPISRRSFPKGFIFGTSSSSYQFEGGAVLGGRGPSIWDTFTHQSPDKITDRSNGDVACDSYHLYKEDVRSMKEMGMDAYRFSISWSRILPSALSGGVNREGISYYNNLINELLSKGVQPFVTLFHWDSPQALEDKYKGFLSPNIINDYKEYAETCFKEFGDRVKHWITFNEPWTFCSMGYASGIMAPGRCSSWEVGKCRVGDSGREPYTACHHQLLAHAETVRLYKEKYQALQKGKIGIILNADWFVPLSQSKSSSDAARRALDFMLGWFMDPLIRGDYPLSMRELVG... | 161 |
A8XUU8 | 5.3.1.8 | ACT_SITE 291; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MEQLQCHVKQYAWGKYGEESEVARLFADGHDNFQIDNNTPYAELWMGTHPDGPAQLKKCSTRLSTYLAKHPSLLTNNNSAKNIHLPFIMKVMSIRTTLSLQVHPTKEQARRLHELDPINYPDRNHKPELAYALTRFELLCGFRPAREILKNLQTFPSFRLLFGGDTYAKPLEDSILEEKKMGVVNQESRKCLENCFRFMMDPDRSDVHNLVSKLLLELDNGLRGAIEEGTVEVIRKMSVDFPNDIGIFSPLFLNHMILEPGQCCYYAAEELHAYLSGECVECVGCSNNTIRAAMTPKYIDRDALCSVLNYKMTEQKDYLV... | 214 |
A0A2I4E9Q5 | 3.1.1.11 | ACT_SITE 119; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | LVKSGVYNEKVETDGSNMKNVMLVGDGIDKTIVIGDINVLDGSSTLNSATFDVSGDGFWARDITFENTAGPYKHQAVALRVSLDCAVFYRCSFRGYQDTLCVHSLRQFYRDCHIYGTIDFIFGDATTVFQNVDIFVRRPMRHQANMITARGRVNPNENTGIAIQGCRVRSASDLSAVKNIYRTFLGRPWKKYSTTVFMKTNLDGLIDPEGWTEWSGNFALSTLFYGEYMNTGIGASTQRRVKWPGFHVLKSPREACPFAASTFIQAESWIPDTGVPIWLGI | 125 |
F6TSK2 | 3.2.1.52 | ACT_SITE 331; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MGCRDFFAVCLLLVGAVHATGKLGYPAPLLGETSPGSVWPQPHTVTASPQLYTIDIQAFRFEYLQTSQRCHVADEAFKRYQLLISRSGIKAKFHDKYSTSVISVLPVMITGPCEDMPSLDMKEGYILDVGSNPLLNASSVWGVLRGLETFSQMIWEDPSGQAVANKTHIIDEPRYAHRGLLLDTARHFLPVNVILENLEAMAYNKFNVFHWHIVDAQSFPYVSTVYPNLHLKGSYSSLNLVYTPEMIAQVIEFARLRGIRVVPEFDTPGHTYSWGLGQPGLLTTCYTGGKPNGDVGPINPTVNSSYTFIKNLFTEVRGQF... | 170 |
Q2FYS4 | 5.6.2.2 | ACT_SITE 119; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00937" | MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYEAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNS... | 222 |
H7C2Z3 | 4.6.1.16 | ACT_SITE 343; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 351; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 390; /evidence="ECO:0000256|PIRSR:PIRSR011789-1" | MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQLYGKGYFGKGILSRSRPSFTISDPKLVAKWKDMKTNMPIITSKRYQHSVEWAAELMRRQGQDESTVRRILKDYTKPLEHPPVKRNEEAQVHDKLNSGMVSNMEGTAGGERPSVVNGDSGKSGGVGDPREPLGCLQEGSGCHPTTESFEKSVREDASPLPHVCCCKQDALILQRGLHHEDGSQHIGLLHPGDRGPDHEYVLVEEAECAMSEREAAPNEEAFFLVYALGCLSIYYEKEPLTIVKLWKAFTVVQPTFRTTYMAY... | 207 |
Q05201 | 3.1.3.48 | ACT_SITE 499; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O00167"; ACT_SITE 501; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O00167" | MVTLMPYNYAAPRCGLIDKMIEPKVKRPKTDHTDTHERNRLCNLSQQQQQQQPQQQQTHQQQQQQQQQSHQQSHSSTVLASNGPSSAGAGMGVGVGGGGGSGGGVGGGVGQCSPLGLPPQSQPLQPTIGSLASLSGHYSNGNANPNVNSSSCSLATASSFAQSAGSSFSTYQQAGGTSGGVSGEDGVVGGATVMSHWTHDGTGSSAAVKSESRSPGQVHASLDNGSVAGSNLYGCSSASNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGYGTPYAAATAARQAKMEPGAAAAAAAYLTPSYAAS... | 149 |
Q93J06 | 3.1.1.3 | ACT_SITE 48; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 275; /evidence="ECO:0000250" | MPKPALRRVMTATVAAVGTLALGLTDATAHAAPAQATPTLDYVALGDSYSAGSGVLPVDPANLLCLRSTANYPHVIADTTGARLTDVTCGAAQTADFTRAQYPGVAPQLDALGTGTDLVTLTIGGNDNSTFINAITACGTAGVLSGGKGSPCKDRHGTSFDDEIEANTYPALKEALLGVRARAPHARVAALGYPWITPATADPSCFLKLPLAAGDVPYLRAIQAHLNDAVRRAAEETGATYVDFSGVSDGHDACEAPGTRWIEPLLFGHSLVPVHPNALGERRMAEHTMDVLGLD | 128 |
A0A9J7HPN8 | 2.7.10.2 | ACT_SITE 352; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037281-1" | MPLKLSSCAGAMDTDPVAQTLDFGDGMGSDGEPTEDSFGSSGLSSPSFTGFRSKADLDTSDKDASLDFWDPDLASPTPNPSPVKRSVRFAASPEASPNTSSSSGDCSPPHKSMQELRLLDTPRTPKTLLRSLSSSARRARRITPTGPSKLFGLSTSEPRHRVMERPAANVNPFTPDNNMVTRATAKRRRQDSGMLSDVDEESDEENPTKKIALHDANVSRYNIEFHEVERIGSGEFGSVYKCINRLDGCLYAIKKSKKPVAGSTDEQNAIKEVYAHAVLGKHPHVVRYYSAWAEDDHMIIQNEYCNGGSLADDLTANQKH... | 98 |
A0A2C9UXM7 | 3.2.1.1 | ACT_SITE 202; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 227; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MNFLSPLCVLSFLLFVFPSFISSQLLFQGFNWESCNKAEGWYNSLKNMIPDLANAGVTHVWLPPPSQSAAPQGYLPGRLYDLNASKYGTQDELVSLIDSFHQKGIKSLADIVINHRTAEKKDDRGIYCIFEGGTPDGTLDWGPSFICRDDTAYSDGQGNPDTGEDFKGAPDIDHLNPRVQIELSDWMNWLKTEIGFVGFRFDFVKGYAPSITKLYMEETLPEFAVGEKWDSLAYGQDGKPDPNQDGHRVALEDWIQAAGGAVTAFDFTTKGILQAAVQGELWRLKDSNGKPSGLIGLFPQNAVTFIDNHDTGSTQNLWPF... | 157 |
A5I5Q4 | 2.7.7.7 | ACT_SITE 104; /evidence="ECO:0000256|HAMAP-Rule:MF_01113" | MDRVIIHVDMDAFFASVEQMDNKKLKGKPVIVGGIGERGVVSTASYEARKYGVHSAMPVFIAKKRCPFGIYVPGRHERYKEVSNNIFKILYKVTPIIEPVSIDEAYLDITNIKEEPIKVAEHIKKRVKNEMGLTLSVGISYNKFLAKLASDWNKPDGIKIIRQDMIPSILMPLPINKIHGIGKKSVEKLNNIGIYTVEDMHKLSRDFCIEYFGKFGVEIYERIRGIDYREVKVSRERKSIGKEITLKKDITNKEEMKKYLLDFSNKVSTNLYKRNTGGKTVTVKIKTSNFQTHTRSKTVNDYIRDKDEIYNIACDILEHI... | 121 |
W5N9Y7 | 2.7.10.1 | ACT_SITE 811; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MKMRLALRVMLVGILSGLQTTVCEKAKPVIASAEEELVIPLHSMVSLNCTGEGGVLWEGPLSRGGAVASGQSFSTLLLLDASASNTGFYTCAFKAHGTAEGAELGEANIYIYVPDPAFPFVPEDAPRQHVQADPPAAVIPCRTSSPSSLVSLKEVETGAEVPSLYDSKRGFIGSFASGTYVCETTEAGVRHYSALYRVGDDKTNSELQVDLEAPNTAVLVGDTINVTCVAKGSEILEDNWKYPGKMAGRGEITLKENKRDVEIRYSLTIKHASLKDSGVYECSITDIMSTNMITKAVTITVYEKGFIQLDPMVSQKEFAE... | 97 |
Q6C7N8 | 2.3.1.48 | ACT_SITE 276; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MHDDPLDDEEEEEPPRNIGRVVFGPREFDTWYHSSAYYFSQKDELKKLTWKRAMALMEAKALDKDKDNHTCDMSRLFIERYSSPSVGTPGGTSSALTSSTISSSGSSANASVAPNDQPPAQVDFQVKQLFVCDSCFKYSKVSKDMAQHRSTCKYVFKHPGETVYKSKDYAIRRVDGAVHKLYCQNLCLFAKLFLDHKSVFFGADAFEFYVVLGKDTASSRHFKPMGFFSKEKLSWDENNLACILVFPPYQRRGLGKLLIEFSYVLSKYEGRKGSPERPLSKFGTLSYMSYWCTTIARFILIECTEDVITIETISEHTYIQ... | 61 |
A0A2I4EF16 | 3.1.1.11 | ACT_SITE 399; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNNLRKRTRFLATFLPISAIVLVLLSQITHLKKSPKTIDNQHILIHKHFQVAHSTCQGTLYPDLCVSTLSSFPDLIAKTPRQIISATVNYTISEVRTSSSNCTGIRQKLKNLDPLGKRALDDCLELFDDTLAELHATICDLFPKKSAPQNNFHNLQTFLSAAMTNQYTCLDGFAYSNGSHVRKVIKNSLYSISHHLSNALAILKKIPSVNKSESEVYPEYGEMKDGFPSWVSGKGRKLLQSSSVNGTKYDLVVAKDGTGNFTTIGEAVAAAPNSSTTRFVIYIKAGAYFENVEVERNKTNLMFIGDGIGKTIVKASRNVV... | 125 |
P53965 | 3.6.1.52 | ACT_SITE 214; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000305|PubMed:29540476" | MGLYQAKNDEGSDPKSSSKIDDLIENEAEIIRLIKEDGKLLIDNGDGRDIHNIIQEDKLLSVEFNEVLKRFHGEEKSDIPRKEFDEDEDDGYDSNEHHQKTIEVMNTLNHVINKEVIPPENFSHVVGEIYRSSFPRQENFSFLHERLKLKSILVLIPEEYPQENLNFLKLTGIKLYQVGMSGNKEPFVNIPSHLLTKALEIVLNPANQPILIHCNRGKHRTGCLIGCIRKLQNWSLTMIFDEYRRFAFPKARALDQQFIEMYDDDEIKRIASKNNWLPLQW | 190 |
A0A1S4H8H1 | 2.7.11.1 | ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 352; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MSSGQFDDALDDTTERFDGVQLQEKATSPPASKVNGTAKLTKIEIQDALFGAPIKDEPTATDAQWEEYYDDEESDDDDDFYCYEGGELKRNQQLNLNQSHTNAQTTSQKVSHYQPADVLFKKFTNRINVEKYEGPASLPNHAKNTLIETQRKADSDRLRSKDKQDRATAEQVMDPRTRMILFKLLNRAMITEINGCISTGKEANVYHATAASGRDYAIKIFKTSILTFKDRDKYVTGEYRFRHGYSKHNPRKMVRTWAEKEMRNLVRMKKCDLPVPEPILLRSHVLVMEFIGHDGWPAPKLKDVELSGVKARELYRAAVE... | 99 |
A0A804I5D1 | 3.1.1.11 | ACT_SITE 432; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGYGRLGSSESVPSVSDLRPSRDASATRKRRFLWLTVVFAVFLLVASGVSVGLVVRGRMRSNSPATRAPTQAIARACSLTRYPALCVSSLLDFPGALQAGERDLVHISLNMTLHRVGAALYGTSAIAGFAMDRLARAAFDDCMELLEESLDQLSNSLLVVAPPVSPSPSSQARIRGASDEDVLTWLSGALTNQDTCDEGLQQVQNLYIKEHMESHMKDLAELVSNCLAIFAGVSRNKDFSGVPIQNRKRRKLLNAIDDDEFPSWMGKKDRRLLQIPAANIQADMVVSKDGNGTYKSIADAVQAAPDYSSRRIIIYIKAGR... | 125 |
I1KMW7 | 3.1.1.11 | ACT_SITE 407; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MATGFDTAHEKKKKIAVLSVSSILLVAMVVAAAVGIRDGAEVVEEGGDTIAKSQRNQQVICESAEYKETCHKSLAKASGTSDLKELIITAFNATAEEIANQIKNSTLYHELATDHMTKQATDICKEVLGYAVDDIRRSVHTLEKFDLNKLNDYAYDLKVWIAGTLAHQQTCLDGFENTSSEAGKTMAKVLNASLELSNNALDIVNGVSSLFKGLNLSSFSVNSNRKLLSEETALVDGFPTWVSEGQRRLLQAVDPKPDVVVAQDGSGQVKTIHEALKLVPKKNKKPFVIYIKAGIYNEYIIMNKHLTYVTMIGDGPTKTR... | 125 |
A0A3Q1LJ39 | 2.3.2.26 | ACT_SITE 760; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MHVCEVTSAVFHSLRPRGQEPSRLLCPGFSRQEYWSGLPGPPSGDLPDPGIEPASLTPLSLAVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTG... | 65 |
A0A6I8PFL3 | 2.7.11.13 | ACT_SITE 723; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000552-1" | MATVPSAAAPAGVPGSPMSPPPPGPEPQSPLPLSPAALPSSPAPGPLLAPAPAPGPGVSFHIQIGLTREVVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPASANLLQLVRSANDIQEGDLVEVVLSATATFEDFQIRPHALNVHSYRAPAFCDHCGEMLFGLVRQGLKCDGETGWGLGTAGAGGRFRVGEGHWGGPVLLCPGLIPASPSHPGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLVSSQSLRLLTTESLPCGTDELTRSSTESFPRRPASSSSYMGRPIELDKLLLSKVKVPHTFLIHSY... | 100 |
A0A0Q3HTF5 | 3.1.1.11 | ACT_SITE 242; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MHANAMPRTRTMRRASRSCSRAGRVIWASSAISSALLAILLASTHLAPSPSTNPPSLLDGRRRHCDEEAKWASSIASRLNITQILTVDRHGCGNFSSIQKAIDAVPDNNNHIGTRTLITVGAGTFHEKVTVWSNKTGLTIHGRGNLNSVVAWDDTAGTTGGCTPCSATFTVLAAGFVAYNVTFRNAAPPAGPGASGGQAVALRVAGDQAAFHWCGFYSAQDTLLDEQGRHFFRGCYVEGSIDFIFGNGRSLYLGCTISSVAAAASGSNAGGITGSVTAQGRRTEAEKTGFAFVRCSVVGTGSVWLGRAWGAYATVVFAET... | 125 |
Q54U65 | 2.7.11.1 | ACT_SITE 506; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPSKEFIIPLILLCFYSVNGFVAVISSLVELFIHKASWNSIKIFFYSLLILQCLCRCIIIGWGMIETVQGGEFYSNFPSLLFISYAGLVALQMIQFLPNDNQYLLLSEGKKNNHKVKVGTNILIFFNLFMYFGMFLLFGIAEKQVGNSTSFNHHGNHNSTTSTSTDEIPLVSTEVGELYLFGDKDPIYIVLDCFYFVCLLLLLIFHSYVGWKTYKRNKDLFGIKLNVIHLILLICIFIRSLLVIIDPSSPNNSILHIDTESWLIYIYTISYYVVGEIIPGMLLIVIEFLLPYHKRKDFINIGGELSSYQDVWKSENIAIH... | 99 |
I1J7T0 | 3.1.1.11 | ACT_SITE 356; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAPPFPFLMTLLLAPFLFSSIASSYSFKDIQSWCNQTPYPQPCEYYLTNHAFNKPIKSKSDFLKVSLQLALERAQRSELNTHALGPKCRNVHEKAAWADCLQLYEYTIQRLNKTINPNTKCNETDTQTWLSTALTNLETCKNGFYELGVPDYVLPLMSNNVTKLLSNTLSLNKGPYQYKPPSYKEGFPTWVKPGDRKLLQSSSVASNANVVVAKDGSGKYTTVKAAVDAAPKSSSGRYVIYVKSGVYNEQVEVKGNNIMLVGDGIGKTIITGSKSVGGGTTTFRSATVAAVGDGFIAQDITFRNTAGAANHQAVAFRSGS... | 125 |
Q9ZAB0 | 3.4.21.92 | ACT_SITE 99; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 124; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MGYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGAGQGTQQTDMAIVAEQLLKTRKRLEQILADNSNRSLEQIHKDAERDHWMDAKETLEYGFIDEIMENNSLK | 179 |
F4JTP5 | 2.7.11.1 | ACT_SITE 411; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MVMEDNESCASRVIFDALPTSQATMDRRERIKMEVFDEVLRRLRQSDIEDAHLPGFEDDLWNHFNRLPARYALDVNVERAEDVLMHKRLLHSAYDPQNRPAIEVHLVQVQPAGISADLDSTSNDAGHSSPTRKSIHPPPAFGSSPNLEALALAASLSQDEDADNSVHNNSLYSRPLHEITFSTEDKPKLLFQLTALLAELGLNIQEAHAFSTTDGYSLDVFVVDGWPYEETERLRISLEKEAAKIELQSQSWPMQQSFSPEKENGQTGARTHVPIPNDGTDVWEINLKHLKFGHKIASGSYGDLYKGTYCSQEVAIKVLK... | 99 |
O64629 | 2.7.11.1 | ACT_SITE 145; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSKKSTESDAGNTEKQWSLADFEIGRPLGKGKFGRVYLAREAKSKYIVALKVIFKEQIEKYKIHHQLRREMEIQTSLRHPNILRLFGWFHDNERIFLILEYAHGGELYGVLKQNGHLTEQQAATYIASLSQALAYCHGKCVIHRDIKPENLLLDHEGRLKIADFGWSVQSSNKRKTMCGTLDYLAPEMVENRDHDYAVDNWTLGILCYEFLYGNPPFEAESQKDTFKRILKIDLSFPLTPNVSEEAKNLISQLLVKDPSKRLSIEKIMQHPWIVKNADPKGVCASIDI | 99 |
Q751S0 | 3.4.19.12 | ACT_SITE 87; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 169; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSSWQTIENDAGVFTQLVKDLGVEGVQFEEVPLVEHLATLNSPLYGVIFLFKYERQNYAGEAPVQGEFEQACPEGLFFAQQTIPNACATQAVLNTLLSIGNDHRNSIRLGTVLSDFLQFTAGFSDPALRGETITNSVAIRNVHNSFTSPDPFEHEEPSPSAQSSEAAFHYSGFVPYNGYIYELDGLHPRPIIHRAYGANNDDPAVFAANLAALLSARMSMVADSSFSVTAIVRDKLEHLTEQLDAPDVDDGRRFWLQDLIQDELRVRDRWAKEIALRRDGLVGLVYAVFKQMLGSMSDDEFAQRRAAAAARTNERERRRT... | 175 |
Q9UR39 | 2.3.1.286 | ACT_SITE 184; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MKVEEHVPLIQESRKRKCQSSENASKRQQLLSKLPLRLHTGNENVDLSPLVSAIRKAKRIVVVTGAGISCDAGIPDFRSSEGLFSSLRAEYKLNCSGKELFDGSVYRDLKSVNIFHAMIRKLHMLSNNARPTDFHLFLSQLAQESKLLRLYTQNIDFLETRLEGLQTCIPLPQSAPWPTTIPLHGTLEVVSCTRCSFLKKFNPDIFDRNGVTVCPDCKTENEVRRIAGKRSVIEGCLRPRIVLYNEIHPDSESIGSVCSQDLKSRPDCLIVAGTSCKIPGVKRIIKEMSNCVHKQKGNVIWLNYDEPTKDFLNLCDLVVQ... | 58 |
Q8ED46 | 3.4.21.89 | ACT_SITE 39; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 93; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MFKGIRILLKDYGSFLLFISLMLVFRSAVADWNTVPTGSMLPTIVEGDRILVNKMAYDVRVPFTHIALVKLADPVRGDIVVFDSKNADKRLIKRVIAVPGDTVMMRDNRLYLNGEPLAYKPQALSPYAPAGVVEMQEDLLGIMHSIRLNQLPSKLANFGPVTVPDEHYLALGDNRDNSADSRVIGFVPRDEIVGRSSSLVFSLDYDNYYLPRPERLMQDF | 178 |
O94561 | 1.11.1.24 | ACT_SITE 89; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P40553" | MDAPRRSSRLAAKIANVLDSKGTIIPEAAPVMLKKPAKDESVDSTIQVGDVIPDITLPDEDGTSIRLRDITANKGLVIFAYPKASTPGCTKQGCGFRDNYPKIQASDYEVLGLSFDTSKAQKAFKDKQNFPYHLLSDPKGELIKKLGAEKPGGGKLFRSHWIFEKGTGKCIVKEIDISPLVSVDKAFAVITDSEP | 12 |
E3K352 | 1.1.1.37 | ACT_SITE 183; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MPSLKVAVLGAAGGIGQPLSLLLKQNPHITELALFDVVPVVKGVAVDISHINTPSTVTGHIPAEEGLAKALKGSDLVVIPAGVPRKPGMTRDDLFKINAGIVRDLATSMAQNCPKACILVISNPVNSTVPIVAEVFKKAGVFDPKKLFGVTTLDVVRASTFVAHVVGQPEKAHEYKIPVIGGHSGVTILPLLSQSKPPLPQSVLSDKSKVEELIKRIQFGGDEVVAAKDGAGSATLSMAYAGFRFAESLIKARLGHTGVVEMGYIYVADDKHISAHTDGLEYFSVPIELGAEGVGKLLPIGDINDHEKEMLKACVSELKE... | 5 |
K3XJJ1 | 1.11.1.7 | ACT_SITE 93; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRRQQVAAAAGAARWRGDGGGGAATAWWWVAAVVLGHLVSSARAGLLESNPGLAYNFYQKSCPKVDSIVRSVTWAQVAANPALPARLLRLHFHDCFVKGCDASILLDNAQSEKKAGPNLSVGGYEVIDAIKTQLEQACPGVVSCADIVALAARDAVSYQFQSSLWQVETGRRDGNVSLASNTGALPSPFAGFNGLLQSFAARGLNLTDLIALSGAHTIGVASCSSVTPRLYNGNATNVDPLLDSAYAKTLMNSCPSSSASGTVNLDGRTAVKFDSSYYTNVLNKQGTLASDAALTQNAAAAQMVQDLTNPFKFYAAFSMS... | 14 |
A9UXK6 | 3.2.1.52 | ACT_SITE 199; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MVTADTIYGAMRALETISQLIQFDYDTNNYFIANAPWAITDFPRFAHREILVDTARHYQSVMAIKSMIDSMTYAKVNVVHWHIVDTQSFPFMSPTYPELGSKGAYSKTERFSPADVAEVVEYARQRGVRVMVEIDTPGHAASWCNGHPEICPSPDCPQPLNPATNKTFDVLSGLFKDVTGGERGAGLFPDNVMHLGGDEVNTDCWASNADISKWLSDQGLTLDGGYAYFVKRAQAIAHGYGRDVVGWEEIWDHFGTQLDKSTIIHQWLGARHASLNLLRPAGALTAGIGYLDGLDVTWQTMYEQEPCTGMTDDQCALVLG... | 170 |
A0A804JK93 | 2.4.1.18 | ACT_SITE 487; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 542; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MAFALAGIRFPTARTARPSSRSGLEGKRRTGASFSLLSRKKRFAGIILTGSSCDTDPTSTTVAASDGVLVPGAESDDLSSSTDMISDTEAASSNLQVSRETTGLMMEESEAGQTSISSEFIGEESMDEDVKDAVSSQAIKRIVDVQEKPRFVPPPGTGQRIYEIDPSLNGYRGHLDYRYDQYKKMRETIDQYEGGLDAFSRGYEKFGFQRSANGITYREWAPGAKWATLIGDFNNWNPNADVMTRKEYGVWEVFLPNNADGSPPIPHGSRVKIRMDTPSGIKDSIPAWIKFSVQAPGEIPYNGIYYDPPEEDKYVFQHAQ... | 73 |
Q5AAS1 | 2.7.11.23 | ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MSTAAVATKPSVTSKPATKQVSNYTKEKKVGEGTYAVVYLGKQISTKRQIAIKEIKTGLFKDGLDMSALREVKYLQELKHPNVIELVDVFSATNNLNLVLEFLPCDLEVLIKDKSIVFKSADIKSWLLMTLRGIHHCHRNFILHRDLKPNNLLLAPDGQLKIADFGLARALVNPNEDLSSNVVTRWYRAPELLFGARHYTGAVDIWSIGIIFAELMLRIPYLPGKDDVDQLDVTFRAYGTPTEQIWPNVSSLPMYNALHVYPPPSRQELRNRFSAATEKALDLLISMTQLDPSRRCDSTLALLHDYFTESPRPTDPKKLP... | 103 |
Q55F83 | 4.2.1.11 | ACT_SITE 208; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 348; /note="Proton acceptor"; /evidence="ECO:0000250" | MSIESIKAREILDSRGNPTLEVEVWTSEGMFSAKVPSGASTGIHEAFELRDGDKSRYFGYGVLNAIVNVNNLISPTLKGMRVDNQKAIDDKMIELDGTKNKSKLGSNAIVGVSMAVARAAASIKGVPLYRYISQLAGNSNIRLPVPCFNVINGGKHAGNRLPFQEFMLVPIGAPKFKEALRYGSEVYHSLKEIIKERYGLDATNVGDEGGFAPNLTSPEEALTLLVDAINHSGYQDVIKIGIDSAASEFWNPKTSKYDMDFKNIGSSHLKSSLNSGEQLMSRYLEILKKYPIAFFEDPFGEDDWENHGKITAAIGNKIQI... | 200 |
G1KL87 | 2.7.10.2 | ACT_SITE 352; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037281-1" | MVRVAMDDWNCSNQPVQKLDFSSCGEDIELEEDNSIHEEEVRPVTPQKDWAFQDWQSNCPIPVTPQRQQDDFSPDLPKSWATPVRKGKESRRKNITPLENYPETPLHYVTWQKLQLCDTPNTPKSLLGKTAFPSPVGKFSPKGIRNLRFNSCTDSEEPPSNSLVNINPFTPDSYRQMVFHPSGKRKTRGELDDPSQKGSPMELGLPAKRFLLRESNMVSRYKKEFLELEKIGVGEFGSVYKCIKRLDGCVYAIKRSKRPLAGSSDEQMALREVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEHCNGGSLQDVLLENLKT... | 98 |
A0A067DSE3 | 2.3.1.41 | ACT_SITE 188; /note="For beta-ketoacyl synthase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000447-1" | KTVAMSATQSENDLIITEKKEPKERRIVVTGLGVVTPLGDDAHLFHTNLLEGVTAISDIQGFDCSEFSTMLDYINLKSLSTDGWVSPKVGKKADKYMIYALVAGKKALADAGITEQVSGELDKRRCGVIIGSAMGGLHVLSDGFEAIKVSYKKMSPFCIPYSLTNTASAALAMDLGWTGPSYSINTACASSNYSILNAANLRIKGDTDIMLCGGSDGAIIPAGIAGLVACNVLSQRNSEPTKAARPWDADRDGFVMGKGAGVLLLEELEQAKKRGASIYAEILAGSLSCDAYHLTAPHPEGVGMVSCMEKALAQSGVAKE... | 60 |
A0A0A0L301 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAETASYINTCKSFLVFLALSFPATTLALSFGFYAATCPAAELMVRNTVRSASSVDPTVPGKLLRLLFHDCFVEGCDASVLVEGNGTERSDPANKSLGGFEVIDSAKRTLEIFCPGTVSCADIVVLAARDAVEFTGGPSVQVPTGRRDGKISAASNVRPNIADTSFSVNQMMNLFSSKGLSVDDLVILSGAHTIGTSHCSAFSDRFRRNPNGQLTLIDASLDGAYADELMRRCPAGASTAATVENDPATSSVFDNQYYRNILSHRGLLQSDSVLISDGRTRARVESFANDEIGFFENWAQSFLKLSSVGVKSGDEGEIRL... | 14 |
B7P6B5 | 1.8.1.4 | ACT_SITE 437; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MQEFDLVVIGSGPAGYTGSIRAAQLGMKVACIEKNDTLGGTCLNIGCIPSKALLNSSEKYEEALKHFESIGITADVKLDLQKMLANKDKVVLDLTKGIESLFAKNKVTRIKGEAKIISSNIVEVNKEQIKAKNILITTGSSVIEIPNIKIDEEFIVSSTGALKFSKVPENLIVVGGGYIGLELGSVWRRLGAKVTVIEYAPSIVPMLDKEIATQFMKLQQKQGIEFKLNTKVLSAVKSGKVNLTIEEGGKSSVVTSDVVLMAVGRKAYTQNLGLESVGIITDKQGRIEINDRFQTAISNIYAVGDVVKGAMLAHKAEEEA... | 36 |
Q04806 | 2.5.1.18 | ACT_SITE 46; /evidence="ECO:0000250" | MSEKSASNNKAEFKRQSSPFREIISADHPIYKPAKGRYWLYVALPCPWAQRTLITRALKGLAPIIGCSVAHWHLDDKGWRFLEEGDGKTNERHWFDIAGGISSVNLNTSTPVANIPNNAHRLLVDGTDEPHYGYKRLSDFYFKTKPDYKGRFTVPVLWDLETCTIVNNESSDIIGIMNSAAFDEFVGEEYRQVRLVPRSLEAQITEFNSWVYDKINNGVYKAGFAECAEVYEREVTSLFQYLDKLENLLDKKYTDLEAEYGKNNKDKILDRYFAIGDTLTEADVRLYPTIVRFDVVYHQHFKCNLATIRDDYSRIHTWLK... | 77 |
Q8EGU7 | 2.4.1.18 | ACT_SITE 415; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685"; ACT_SITE 468; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685" | MTQAQTYFYDGSDVALLNGQYTDVFSLLGMHSINEGKALVVRCFLRNAQKVDVISLKDGRKVASLERVNEAGLFAGTLGRRIKPFLYALRVTYPLCELDIIDPYQFGSLLNREDLYLFGEGSSEQAYRFLGANWRQVDNVEGVHFCVWAPNAKRVSVVGDFNHWDDTRHVMRQHVANGLWEIFLPGVVEGSHYKFDLVYQNGERHAKSDPMATQMECAPHNASIVPKKQQHQWADTQWMDKRAATAWHRAPMSIYEVQLGSWRRKGEFGEQYFDYQDLIEQLIPYVKEQGFTHIELMPVSEYPFDGSWGYQPVGLYAPTY... | 73 |
O13811 | 5.3.4.1 | ACT_SITE 51; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 54; /note="Nucleophile"; /evidence="ECO:0000250" | MRLPLLSFVIFALFALVFASGVVELQSLNELENTIRASKKGALIEFYATWCGHCKSLAPVYEELGALFEDHNDVLIGKIDADTHSDVADKYHITGFPTLIWFPPDGSEPVQYSNARDVDSLTQFVSEKTGIKKRKIVLPSNVVELDSLNFDKVVMDDKKDVLVEFYADWCGYCKRLAPTYETLGKVFKNEPNVEIVKINADVFADIGRLHEVASFPTIKFFPKDDKDKPELYEGDRSLESLIEYINKKSGTQRSPDGTLLSTAGRIPTFDEFAAEFLDMSNAAKEVVLEKVKQLALEDSSRWTKYYKKVFEKILNDENWV... | 215 |
A0A0D1C522 | 3.4.19.12 | ACT_SITE 26; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 26; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 127; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 145; /evidence="ECO:0... | MSSLSPQQQLIEYIHHERQEAGSMLCAQHALNSLLQGQYYDASQLAQIATELDQLEATELGLSQADIAARDRSSLNMDDTGFFSASVLERALQVWGISISSWRSAEVRGRHSAPEREAAFVLNLDSHWFTIRSFGTTSQFWYNLNSFLAEPQWIGTNYLGTLLHTAESEGYSVFVVQASEGSAGQGLRESDADQIADHLPPPGAASSRIDSSSQSLGLRPATSSNRSTSPLRSAAKSGTSSTSLGLGDDEEDVDLQAALSASLVQHTTASGDPDTPSRSRVRQVRSGSDEGIAGGYSSMGETDADIDAIAPSRQRHRTGF... | 175 |
A0A067H6D4 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKKAAGAGSLLLVCLVVFGIIGVCQGGELRKNFYRDSCKSAEDIVRSITWKNAASNPDLPAKLIRMHFHDCFVRGCDASVLINSTAGNKAERDAVPNLSLGGFEVINEIKSELESRCPGIVSCADIVALATRDSVSFQFQKPDLWEVLTGRRDGSVSIAAEADLLLPSPFANFSELKKNFNDKGLTVKDLVVLSGGHTIGVSHCTFFSNRLYNFTGNGDQDPSLDPRYAAFLKTKCKSLADTTTTAELDPGSFRKFDSHYYDILIENKGLFQSDAALLTNKGARNIVMELRNQDKFFTEFAQSMKRMGAMNVLTGTQGEI... | 14 |
A6ITS7 | 2.7.10.1 | ACT_SITE 740; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MKLRAAGFCLALLWGCALAAAAAQGKEVVLLDFAAMKGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVVSGDQDNWLRTNWVYREEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDVDYGTNFQKRQFTKIDTIAPDEITVSSDFEARNVKLNVEERMVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPEMLQSLARFPETIAVAVSDAQPLATVAGTCVDHAVVPYGGEGPLMHCTVDGEWLVPIGQCLCQEGYEKVEDACQACSPGFFKSEASESPCLQCPEHTLPSTEGATSCQCEEGYFRAPED... | 97 |
A0A8I3MVZ3 | 2.7.11.1 | ACT_SITE 179; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MCHIRGGMCSGYNRMYAHGFPGMCPATGLCTVGTQAQLQRPGMDLVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVTGDLVAVKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKFWICMEFCGAGSLQDIYQVTGPLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFVKVTLTKNPKKRPCATKMLSHQLVSQPR... | 99 |
A0A2K3D502 | 2.3.2.26 | ACT_SITE 1465; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MKPGLKFPGMAELASHASSTGGPPPEFASRALRLVASNNFADPVFLEELVESNLVAALCATLPALKAKAASRTGSTGIQDLTDLEEALRKLRHELALAEKRLPSGGSGAAYYPSWACVGYVAVLMQQAIVHGAAAAAAVAASGAAAAALALAAGSAGAGTRASQPAYSPGADDAASTRTVDGSGDGADTPAAAANGGPAPSTAPGTGATTPAPAGPLAAFAASVAVAAAGGNSASGTSTPGGTVSAFKLATSSATASPAAAGAVMPALATEAQLVKLLSNKHVLLRAKEVVRAIPAQYAPAVGRVLLGQLSTDLKGVQSS... | 65 |
Q9UTM7 | 2.3.1.48 | ACT_SITE 238; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q12341" | MSAVDEWVHNANECIEIVQVNEKHEKDCQYHPSNTYAIFGDAEVIYGYKDLNVTITYECPLMVPKLEISYSERLAPDSGVEPTDIEGTLNTYLKDRSIKVEGNSFDVHSANSIHNYSFNGKTFKILQATVLEASEIMQHLQIFSLFFIEGGSFIDLNDPRWMVYLLYETTEDDYCLRGYCTVYKYYKWDKLIHDGIRARISQFVILPPFQHQGHGSQLYNAIVSTFLKNPKILDFTVEDASEAFDSLRDHCDYKRLLSMGIFSEPDFHPSLSRQWINSKIAETKLTQRQFSRCCELAFTTKLKKLSLLERKSVRLGIKER... | 61 |
A0A3B6SFK4 | 2.7.11.1 | ACT_SITE 299; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 315; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MVHVELDRADEWSESDVSEDVSDSEVGDGLDWLDAVESHDGSARLSAAFSIVGGAAAARRPNAHGGVLSRPFQPLSNRTQKLASHIRATPLEEWEGRMNVGMSNSVTTAIRDSIRDTSIGKIRNHEKADRATVEQAIDPRTRMVLFKMLNSGVFNNINGCISTGKEANVYHATKIDGQELAIKVYKTSVLVFKDRDRYVQGDYRFRYGYCKHNPRKMVKTWAEKEMRNLKRVAAAKIRCPAPLLLKLHVLVMEFIGKGGWAAPRLKDAALSVDKLREAYFEIVTIMRTLYQKCKLVHGDLSYNILYFKGHLYIIDVSQSV... | 99 |
Q9S2C0 | 2.7.11.1 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSQDGGQGRYAGRALAGGRYQLRDLLGEGGMASVHLAYDSVLDRQVAIKTLHTELGREQAFRERFRREAQAVAKLTHTNIVSVFDTGEDDLDGMTTPYIVMEYVEGRPLGSVLDEDVRQQGAMPADKALKITADVLAALEISHEMGLVHRDIKPGNVMMTKRGVVKVMDFGIARAMQSGVTSMTQTGMVVGTPQYLSPEQALGRGVDARSDLYSVGIMLFQLVTGRLPFDADSPLAIAYAHVQEQPVAPSAVNRALPPAVDALVARALKKNPNERFPSAEAMRDECLRVAASFQAAPPSIVPGAQTSSGAGVGSAVFPPV... | 99 |
H2MR11 | 2.7.11.1 | ACT_SITE 846; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1" | MSSQDSQTDDYAVQQENELEALASIFGEDFHDLRSKDPWKVKRPPEVYLCLRPNGLNNGQECYVTVDLQVKCVPTYPDVPPELELKNAKGLSNEKLQNLQDELTKLAAVRCGEVMIYELADHVQGFLSKHNKPPSRSFHEEMLKNQRRQQEKQALEEQQRMDRQRQKEEEMEKEIMAVIQKREEEKREEKRRKEIAKQERLESIESVSVLGKSPPSSGGTAAELTEAKAAAGNQRRTTSSSRHRRDTVNDDGLRPQELLHFHSNTLGELVVHKGKCLGESQRLGRSVYCAFEANSGEFSVLYEWSLRWSKKMGKFFTSQE... | 99 |
O34507 | 2.7.11.1 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRFDYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITANGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALSSTTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSIALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRLNEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKT... | 99 |
A0A3P6A6M3 | 1.11.1.7 | ACT_SITE 95; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAKNQQTLARFLFSLVLFLALLLYVDGKTDSHSNGHNNGHNNGHATRRGRWEGKLKMKFYHKTCPEAEDIVNEIVSKKVKANPSLAAKLLRVHYHDCFVRGCDASLLLDSVAGKAASEKEARPNLSLVGFEIIDEIKSILEDRCPKTVSCADILTLAARDAVSYQYGRPLWNVFTGRVDGRVSLATEATRDLPSAGANFTSLLKLFADSDLDVVDLVALSGAHTIGTARCGVFGRRLLNFTGKGDTDPSLNSSYASFLKSKCSDKSQRLINSSAVVGMDPTGALSFDSGYFVSLLQHKGLFTSDAALLTDPSAAHIASVF... | 14 |
F7B963 | 3.5.4.5 | ACT_SITE 60; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MSIKYTTPEALIALAVEAKQRAYCPYSKFQVGAAVVVENGDVFTGCNVENACYPVGVCAERTAICKAVSEGHRKVEILALTSNADTMTYPCGLCRQTIREFGTEVTIYCASKDGSYETHDLNEMLPLSFGPESLGQ | 187 |
A0A059B996 | 3.1.1.11 | ACT_SITE 250; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGSKKTCLAVLIVVLAVFSSTNFMVPVLLSSLRDLSLDAELFTCLSSGLSPLFGWHLGCHHHRHRHKHPDDSQRTVSICDNFPPDIPPPETNTTVTLCVDRNGCCNFTTVQAAVDAAGNFSQKRTVIWINSGIYYEKVTILRTRPNITFQGQGYLSTAIAWNGTASSSGGTFYSGSVQVFSNNFMARNISFMNIAPIPNPGDVGGQAVAIRISGDQASFWGCGFFGAQDTLHDDRGRHYFRDCYIQGSIDFIFGDARSLYENCQLISIAAPVPPGQKVINGAVTAHGRASKDENTGFAFMNASIGGTGRIWLGRAWRPFS... | 125 |
A7SDY8 | 3.4.19.12 | ACT_SITE 16; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 118; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 133; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MENGSIYHEKQNHMLCAVHALNNLFQDPNAFSKKSLDDICYLLDPNSTINAHKNPLGLGNYDVNVVMAAVNQKGCEAVWFDRRMNPDCLDLDNIFGFIINTPSGMNIAGIGLPIKRPHWYGVRKIETCYYNLDSKLPCPKDLGDNNQMIHFL | 175 |
Q9V9J3 | 2.7.10.2 | ACT_SITE 370; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MGNCLTTQKGEPDKPADRIKLDDPPTIGVGVGVPQIPMPSHAGQPPEQIRPVPQIPESETAGANAKIFVALYDYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTRSEGYIPSNYVAKLKSIEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIIT... | 98 |
Q5B631 | 2.3.2.26 | ACT_SITE 1190; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFTTFTGNSRRPRQVNLSGRTNNPFAAYPSGRQNPHGPGPQSTLAIAQQERQLRQLERDRLGASRVVQRTWRGYWSRKIMRGKWRAEWDTTETARTDSLPSFDDMAKQPSSAVQPAAPFESAAACLSQLRLLVQFIEPWNGGDIVRLVYFSDAFQKTLHEVPSLATEGEWTMLLKRLAEITLRVLQSASSPNVPAYAVGRLLQLLKFLTDLIPKQMARLAREYYSTMAVITNNHDSISSRSPLSKSDIVQSVLTLLLPITSETLTAYEWFAKSYLTIPNLLEKLGSLDFLANNINYKLLTSALAPLHLAQSQDSDAVESR... | 65 |
A0A139WF01 | 2.3.2.26 | ACT_SITE 879; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MASENIYGYFPQIGLDRLTEEPTSKIRLRIIRGKNLMKKDIFGASDPYVKIDLNTINGDETIDSVLTKTKKRTLNPEWNEEFIFRVKPAEHKLILQVFDENRLTRDDFLGMVEITLINLPREQEGRNIGTVKYLLGRRSSFSARSRVRGHLEIYHAFLHDSEVPPAPPDSDRIGNERDWEIMSDGREEGPAQPVYVNDPFESNAPLPPGWEERQDANGRTYYVNHIARTTQWERPTSSNNVDNQLQEQRVLEQAVVFERRYHISAEDENNGRGDSSASQAVSPSSDGAAAGGPDSNVVIPVLDLNNLPEIRVESDDVDDT... | 65 |
A0NGQ6 | 4.6.1.16 | ACT_SITE 214; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 222; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 255; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MSRIVVNFMHGRGFIFNAEDYLKLRFEYRIVGNLIGVPVSHPRNVNQQGMPVALSAYEVKLLLDKEIITLVDKTGALQRVPSDEQSQQYGAMVEQQKQEMHMPVVEKRLEAFRKHMPRIIEGKRRKLLKSGVKEEDIHLDPEELLDQEKKRIMQEKFDQMVQIPLKYPLTLEFSECSIALSAQEDVKYRVFKSLWQQGGFITTGDAFGCDFLLYPGDPMCFHASHTVHVLAEGVSRKLDAKYLIRICRLSVVVNKLCVIAYVDESSDEVHFETLEWEGNVTNKGDTF | 207 |
F1A0X7 | 3.2.2.27 | ACT_SITE 179; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MSTKITDFFTVVSKKEEKVKEKEKEQDLDSSETENEEEKKKKLPTKKTTPKKSPSEKEEVEEKKEKKESSKKRKSPEPDETTEEEGCENQDDEKEIKKNKVEVTDSNYYDDIESYISDVNWKNALQDEFKKTYFKNLISSLNKVKKENKKPIYPPKDEVFSAFNYTPLKDVKVVIIGQDPYHGKGQAHGLSFSVKPGVSPPPSLINIYKELVQDCPPFKQPLKNGFLEPWAKQGVFLLNAALTVEESTPNSHKDFGWYQFTDAVLKILNEQPQPIVFILWGGFAKKKKSILKGKHHFILESGHPSPLSVTHFKGCKHFSK... | 173 |
Q9M1G3 | 2.7.11.1 | ACT_SITE 466; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAQGLHLIWVIFCLHLICISSQQETEFIFNGFGQADLYTDGVAKILPNGLLQLTDGSGQKMGHAFFKKPFEFKSPRSFSFSTHFVCALVPKPGFIGGHGIAFVLSASMDLTQADATQFLGLFNISTQGSPSSHLVAVELDTALSAEFDDIDANHVGIDVNSLMSIASTPAAYFSEIDGENKSIKLLSGDPIQVWVDYGGNVLNVTLAPLKIQKPSRPLLSRSINLSETFPDRKFFLGFSGATGTLISYQYILGWSLSRNKVSLQTLDVTKLPRVPRHRAKNKGPSVVLIVLLILLAIIVFLALGAAYVYRRRKYAEIREE... | 99 |
A0A6I8NR41 | 2.7.11.1 | ACT_SITE 314; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038189-1" | MSKTVTPSTYVRCLNFGLIRQLADFIDPQEGWKKLAVDIKKPSGESKYNQLHIRRFEGLIQMGKSPTCELLFDWGTSNCTVGDLVDLLIRNQFLAPASLLLPDAVPKTDQTFPLPSQETLPIQEKPVPPLDKEKTTTLPGMAQNHEYYSFPDSTSSDTNSVEFSDTRFHQFSFQELRSVTSNFDERPISIGGNKMGEGGFGVVYKGSISNRVVAVKKLAAMVDISTQELKQQFDQEIKTMAKCRHENLVELIGFSSDGDDLCLVYVYMPNGSLFDRLSCLDGTAPLSWHTRCDITQGIASGISFLHENHHIHRDIKSANI... | 99 |
A0A0K9NMN6 | 3.1.1.11 | ACT_SITE 513; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MIGRYDDVDRSQQTDAQKKVRKRMMIMGISLVILVGVLVTVILVTSREDKKNTAQMAETVSSSSKIQTQLNAICNLTLYPSSCIGSMQPLANSSGDVNLTTVFKFALKVVIQELNGVSMKFDHLDVGNDTSYYNVKALNDCKDLVVLALEKINQTVDTNVDFTSKSIVDDMKTWLSSTITYQETCVDGFQNGTVDFRSFTGDTLSNSTEMASNSLAMLSAAAKFFDGLQFKRRRKLLSSDQDADVPYWVGPRFRRLLQFGNNNFDHFGHSGNFGYNWQPWKFNYDPNFWKSYGRAKNNTTDTGNGDAVNNSVDATDNGGA... | 125 |
O69886 | 3.4.21.89 | ACT_SITE 114; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 184; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MGDVAVGARSGHDGEENRGRPEERSGPAAVGAPDSGHGSGTEDGRVTNGQRGQDGHNGGTEDEGVGGTPPATPPAAKKQRSFWKELPILVGIALVLALLIKTFLVQAFSIPSSSMENTLQIGDRVLVDKLTPWFGSEPERGEVVVFHDPADWLAGEPTPDPNALQTVLSWIGLMPSAEEKDLIKRVIGVAGDTVECNKTGPLKVNGKALNEPYVYPGNTPCSDDDQGGRFKVTVPEGKIWVMGDHRQNSRDSRYNQSDKNGGMVPVDEVVGRAIVVAWPMNRWGTLPVPDTFDQDGLQARSSAAAALSVAPQGLAVAGVV... | 178 |
A0A0A0LKG3 | 3.2.1.52 | ACT_SITE 333; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MAPHSHSSAILLLLLFFYFSVSFAAPPSNEIAGGVRIWPLPVSVTHGGHHRLYVAKDFHLITQGSNFSDASRILEDGFSRLLDLVRVAHVVDANLSRFASSSLLHGIHIVVSSPSDELQYGVDESYRLSVPGPAPGKPAYAYLQARTVYGALHGLQTFSQLCSFNFESRVIEVRMVPWNIIDQPRFSYRGLLIDTSRHYQPLAVIKKVIDSMAYAKLNVLHWHIVDTQSFPLEMPSFPNLWFGAYSKQERYTIADATEIVRYAQRRGVSVLAEVDVPGHALSWGVGYPALWPSKDCQQPLDVSNEFTFQVIDGILSDFSK... | 170 |
Q69ST6 | 5.3.4.1 | ACT_SITE 107; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 110; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 453; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 456; /note="Nucleophile"; /evidence="ECO:0000250" | MWPRAPATPPPPPWPSKPSAASRSALRRLDLDDGRRQGTEGEENHAPLLCSPAMASSTAFAAAFALLLLASSAAAEGEAVLTLDAGNFTEVVGAHDFIVVEFYAPWCGHCNQLAPEYEAAAAALRSHDPPVVLAKVDASADLNRGLAGEHGVQGYPTIRILRDRGARSHNYAGPRDAAGIVAYLKRQAGPASVEIAASASPPAADSIANDGVVVVGVFPELSGSEFESFMAVAEKMRADYDFRHTTDAGVLPRGDRTVRGPLVRLFKPFDELFVDSQDFDRDALEKFIESSGFPTVVTFDTSPANQKYLLKYFDNAGTKA... | 215 |
Q9KQK0 | 1.8.4.12 | ACT_SITE 136; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01126" | MVSEAISKKEIERVKFESKDLHKPDEYWREHLTEEAFYVCRQQGTEAPYSGKLLHNKDTGLYHCTCCQSALFSSENKYDSGCGWPSFDAPINEQVIRFLDDFSHGMVRTEIRCAACDSHLGHVFEDGPKTTGLRFCVNSVSLIFNKK | 40 |
A0A9R0IAJ9 | 3.2.1.143 | ACT_SITE 299; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 317; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 318; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MKIRGAKKSTLNKSIDRKKMAKPFTPTMENRTDFESVRQFLPPLTTQPSGHLAWPNHKLIDTLKLISQGPSQSQVNSGARLFSTISRLRDCLPFSSDQDRLATSTGNGFARFFDELLPKEKTIKWFGEIVPVMADFILRLPSLLEMHYQNCDDIVPGVSTGLRLLEPQQPGIVFLSQELIAALLSCSFFCLFPAVIVNRYANLMQAINMDQIFASVHDRFHEQENKIECIMHYFERVCSSTPLNFVSFERKVLSLEQNPSVVALPPPKFWANSVVPLCKFKVYFTGMIEDHPAGSLEVDFADEYIGGLTLTDGCLQEEIL... | 159 |
A0A8D1VEY7 | 3.1.1.4 | ACT_SITE 51; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 92; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | NVLNFHKMIKLKTGKSPVPNYAFYGCYCGLGGKGSPKDATDFCRHRCCAAHDCCYKQLKKRGCGTKLLSYKFVFYQGQTIGDDCRRRLCQCDKIAADCFARNLRTYNVKLQYYSNLRCTGTECCS | 130 |
Q9FM85 | 2.7.11.1 | ACT_SITE 209; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNCWCRFEPLNHRVSANAKSESPKEQSPTVEDKHIKEVQKLPSNPKEVEDLRRDSAANPLIAFTYEELKNITSNFRQDRVLGGGGFGSVYKGFIKEDLGDQEVPEPLPVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLIGYCCEDNHRVLIYEYMARGSVENNLFSRVLLPLSWAIRMKIAFGAAKGLAFLHEAKKPVIYRDFKTSNILLDMDYNAKLSDFGLAKDGPVGDKSHVSTRIMGTYGYAAPEYIMTGHLTPGSDVYSFGVVLLELLTGRKSLDKSRPTREQNLIDWALPLLKEKKKVLNIVDPKMN... | 99 |
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