spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1005": 0.0038986403960734606, "1020": 0.6689305305480957, "1044": 0.020300358533859253, "1048": 0.49982786178588867, "1050": 0.07159364968538284, "1055": 0.4196864068508148, "1062": 0.6374238729476929, "2004": 0.20660123229026794, "2007": 0.04487626627087593, "2012": 0.46486347913742065, "2029": 0.16359257698059082, ... | 1649738 | Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy–induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treated with radiation therapy as children but not as adults. The variants comprise a risk locus as... | Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma |
{"1011": 0.15777134895324707, "1038": 0.5968599319458008, "1048": 0.9310253858566284, "1056": 0.5849615335464478, "2007": 0.2749055027961731, "2008": 0.04394211992621422, "2011": 0.07250232994556427, "2015": 0.3106105625629425, "2020": 0.13414156436920166, "2025": 0.0029254043474793434, "2029": 0.21293537318706512, "20... | 1667063 | To elucidate the transcriptional 'landscape' that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitor cells spanning the earliest stages of B lymphoid and T lymphoid specification. Over 3,000 genes... | Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages |
{"1011": 0.3019835948944092, "1015": 0.14433705806732178, "1055": 0.5528968572616577, "1056": 0.2659635543823242, "1058": 0.8349450826644897, "1062": 1.178053855895996, "2005": 0.007782140281051397, "2008": 0.09850110858678818, "2012": 0.18004031479358673, "2015": 0.1358480453491211, "2020": 0.08513788133859634, "2028"... | 1669173 | The Arabidopsis genome contains a family of v-SNAREs: VTI11, VTI12, and VTI13. Only VTI11 and VTI12 are expressed at appreciable levels. Although these two proteins are 60% identical, they complement different transport pathways when expressed in the yeast vti1 mutant. VTI11 was identified recently as the mutated gene ... | The VTI family of SNARE proteins is necessary for plant viability and mediates different protein transport pathways. |
{"1011": 0.1221139207482338, "1015": 0.040196798741817474, "1019": 0.009718249551951885, "1042": 0.5220900774002075, "1996": 0.11517547070980072, "1997": 0.11256109178066254, "1999": 0.016465263441205025, "2005": 0.0842406153678894, "2007": 0.4248080551624298, "2008": 0.030771657824516296, "2011": 0.32341301441192627, ... | 1676568 | Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs assemble near the leading edge, grow and mature as a result of contractile forces and disassemble underneath the advancing cell body. We rep... | CLASPs link focal adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover |
{"1011": 0.24171993136405945, "1018": 0.3601844012737274, "1043": 0.04767346754670143, "1055": 0.4487839937210083, "1060": 0.5483922958374023, "1999": 0.07159364968538284, "2002": 0.7076893448829651, "2004": 0.012615402229130268, "2005": 0.0038986403960734606, "2011": 0.16442140936851501, "2015": 0.5330380201339722, "2... | 1684489 | BACKGROUND Production of the GTP-bound form of the Ran GTPase (RanGTP) around chromosomes induces spindle assembly by activating nuclear localization signal (NLS)-containing proteins. Several NLS proteins have been identified as spindle assembly factors, but the complexity of the process led us to search for additional... | CHD4 Is a RanGTP-Dependent MAP that Stabilizes Microtubules and Regulates Bipolar Spindle Formation |
{"1009": 0.25845035910606384, "1011": 0.1946154683828354, "1014": 0.045809537172317505, "1019": 0.0354953333735466, "1020": 0.0029254043474793434, "1038": 0.0317181795835495, "1042": 0.3248254358768463, "1049": 0.49030399322509766, "1052": 0.09495500475168228, "1053": 0.00875066313892603, "1999": 0.4920966327190399, "2... | 1686881 | BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart failure but is associated with sudden death, conduction disturbances, and an increased risk of complications during anesthesia. Although cardi... | Myocardial muscarinic receptor upregulation and normal response to isoproterenol in denervated hearts by familial amyloid polyneuropathy. |
{"1011": 0.35403475165367126, "1019": 0.5104349255561829, "1020": 1.035461664199829, "1048": 0.6400018334388733, "1052": 0.6502478122711182, "1055": 0.5267143249511719, "1060": 0.4794800877571106, "2011": 0.05417001247406006, "2012": 0.10379679501056671, "2015": 0.07159364968538284, "2029": 0.3141832649707794, "2071": ... | 1686997 | The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this pathway, to tumorigenesis remains unclear. We found that suppression of 6PGD decreased lipogenesis and RNA biosynthesis and elevated ROS levels in... | 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling |
{"1011": 0.09850110858678818, "1015": 0.2637155055999756, "1016": 0.13243216276168823, "1017": 0.3824150264263153, "1018": 0.4487839937210083, "1019": 0.27934664487838745, "1039": 0.5295937061309814, "1045": 0.5618454217910767, "1050": 0.14686977863311768, "1052": 0.48430517315864563, "1999": 0.045809537172317505, "200... | 1695604 | All eukaryotes have three nuclear DNA-dependent RNA polymerases, namely, Pol I, II, and III. Interestingly, plants have catalytic subunits for a fourth nuclear polymerase, Pol IV. Genetic and biochemical evidence indicates that Pol IV does not functionally overlap with Pol I, II, or III and is nonessential for viabilit... | Plant Nuclear RNA Polymerase IV Mediates siRNA and DNA Methylation-Dependent Heterochromatin Formation |
{"1011": 0.15359249711036682, "1017": 0.7144040465354919, "1597": 0.09050461649894714, "1999": 0.12038381397724152, "2003": 0.2763880789279938, "2004": 0.07612881064414978, "2008": 0.10731173306703568, "2011": 0.24325250089168549, "2029": 0.21214580535888672, "2031": 0.006812678650021553, "2038": 0.09317722171545029, "... | 1701063 | Semaphorin 3A (Sema3A) is a diffusible axonal chemorepellent that has an important role in axon guidance. Previous studies have demonstrated that Sema3a−/− mice have multiple developmental defects due to abnormal neuronal innervations. Here we show in mice that Sema3A is abundantly expressed in bone, and cell-based ass... | Sema3A regulates bone-mass accrual through sensory innervations |
{"1040": 0.19862671196460724, "1054": 0.10467668622732162, "2000": 0.02792670577764511, "2003": 0.22626367211341858, "2011": 0.10026945173740387, "2028": 0.46853771805763245, "2042": 0.025073638185858727, "2046": 0.554580807685852, "2060": 0.07431721687316895, "2064": 0.05786345899105072, "2067": 0.19782574474811554, "... | 1709625 | The direct lineage reprogramming of one specialized cell type into another using defined factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of differentiated cells. With the rapid increase in cell types generated through direct conversion in recent years, this strategy has becom... | Direct lineage reprogramming: strategies, mechanisms, and applications. |
{"1011": 0.12728634476661682, "1041": 0.4337083101272583, "1157": 0.09850110858678818, "1996": 0.020300358533859253, "1998": 0.055094651877880096, "2029": 0.15023678541183472, "2043": 0.05970508232712746, "2046": 0.03266380727291107, "2051": 0.5729197263717651, "2053": 0.08782484382390976, "2075": 0.5197699069976807, "... | 1710116 | We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed in multiple cortical areas, mostly within an early time window (<300 ms), accompanied... | Converging Intracranial Markers of Conscious Access |
{"1015": 0.21922965347766876, "1016": 0.7389566898345947, "1019": 0.40611594915390015, "1038": 0.37640097737312317, "1039": 0.083342544734478, "1042": 0.6823468804359436, "1043": 0.6619023680686951, "1044": 0.4425300657749176, "1045": 0.4041621685028076, "1056": 0.7755908370018005, "1609": 0.36967599391937256, "1998": ... | 1711571 | PURPOSE Patients with type 2 diabetes mellitus (T2DM) have an increased fracture risk despite having higher areal bone mineral density (aBMD). This study aimed to clarify the association between glycemic and insulin resistance status and bone microarchitecture, and whether pentosidine and bone turnover markers play any... | Hyperglycemia is associated with increased bone mineral density and decreased trabecular bone score in elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men (FORMEN) study. |
{"1011": 0.2478361576795578, "1041": 0.14939609169960022, "1044": 0.6778947114944458, "1048": 0.175953671336174, "1052": 0.4855078160762787, "1061": 0.16442140936851501, "2003": 0.1873544454574585, "2011": 0.12038381397724152, "2029": 0.1619328260421753, "2033": 0.4574742913246155, "2039": 0.02412080205976963, "2054": ... | 1727042 | Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins. We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and pervasive processes that promote PH. In multiple pulmonary vascular cell types, such ECM stiffening induced the microRNA-130/301 family via... | Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. |
{"1011": 0.20580662786960602, "1048": 0.43812891840934753, "1051": 0.8805016279220581, "1996": 0.06337817758321762, "2005": 0.06977381557226181, "2011": 0.27786844968795776, "2013": 0.2983669638633728, "2015": 0.13670019805431366, "2029": 0.18248429894447327, "2064": 0.2749055027961731, "2073": 0.2576959431171417, "208... | 1727493 | Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum. However, the omental stromal cell-derived molecular determinants that modulate ovarian cancer growth have not been characterized. Here, using next-generation sequencing technology, we identify significantly higher levels of microRNA-... | Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1 |
{"1047": 0.34922540187835693, "1999": 0.04860413447022438, "2007": 0.22001366317272186, "2029": 0.2409527748823166, "2043": 0.3353555500507355, "2050": 0.1011524572968483, "2076": 0.5551415085792542, "2089": 0.022212404757738113, "2109": 0.40220460295677185, "2139": 0.2711893916130066, "2146": 0.5057345628738403, "2166... | 1733337 | Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in all... | Age-related changes in kynurenic acid production in rat brain. |
{"1011": 0.28890204429626465, "1016": 0.2105647772550583, "1017": 0.1693800985813141, "1041": 0.5086748600006104, "1044": 0.2852376699447632, "1047": 0.5313173532485962, "1048": 0.4311734735965729, "1052": 0.46853771805763245, "1062": 0.02887592278420925, "2004": 0.10555581003427505, "2005": 0.11604541540145874, "2008"... | 1744097 | Polycomb group (PcG) proteins form multiprotein complexes, called Polycomb repressive complexes (PRCs). PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of histone H3 (H3). Suz12 is essential for PRC2 activity and its inactivation results in early leth... | The polycomb group protein Suz12 is required for embryonic stem cell differentiation. |
{"1039": 0.08064348995685577, "1048": 0.11256109178066254, "1052": 0.6563454270362854, "1996": 0.22937409579753876, "2003": 0.25239890813827515, "2005": 0.056018441915512085, "2008": 0.08871890604496002, "2011": 0.29619070887565613, "2015": 0.495672345161438, "2024": 0.48068851232528687, "2029": 0.09050461649894714, "2... | 1744752 | Proteasomes are cylindrical structures that function in multiple cellular processes by degrading a wide variety of cytosolic and nuclear proteins. Substrate access and product release from the enclosed catalytic chamber occurs through axial pores that are opened by activator complexes. Here, we report high-resolution s... | The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions. |
{"1007": 0.05046287178993225, "1011": 0.25694093108177185, "1020": 0.12556517124176025, "1997": 0.018384648486971855, "1999": 0.10555581003427505, "2004": 0.0019512200960889459, "2005": 0.14602625370025635, "2011": 0.16359257698059082, "2029": 0.11430477350950241, "2046": 0.39433568716049194, "2076": 0.1792243123054504... | 1748921 | Translational fidelity, essential for protein and cell function, requires accurate transfer RNA (tRNA) aminoacylation. Purified aminoacyl-tRNA synthetases exhibit a fidelity of one error per 10,000 to 100,000 couplings. The accuracy of tRNA aminoacylation in vivo is uncertain, however, and might be considerably lower. ... | Innate Immune and Chemically Triggered Oxidative Stress Modifies Translational Fidelity |
{"1006": 0.045809537172317505, "1009": 0.7960633039474487, "1011": 0.07068414986133575, "1048": 0.21372433006763458, "1054": 0.5941681861877441, "1996": 0.16442140936851501, "1997": 0.007782140281051397, "2003": 0.3346569836139679, "2004": 0.1930064558982849, "2008": 0.1332872211933136, "2010": 0.6926587820053101, "201... | 1754001 | The sirtuins are a phylogenetically conserved family of NAD(+) -dependent protein deacetylases that consume one molecule of NAD(+) for every deacetylated lysine side chain. Their requirement for NAD(+) potentially makes them prone to regulation by fluctuations in NAD(+) or biosynthesis intermediates, thus linking them ... | Yeast sirtuins and the regulation of aging. |
{"1044": 0.10379679501056671, "1998": 0.3810817003250122, "1999": 0.0354953333735466, "2005": 0.4920966327190399, "2007": 0.6548244953155518, "2029": 0.06612417846918106, "2051": 0.08244366943836212, "2064": 0.1510767638683319, "2078": 0.3019835948944092, "2090": 0.3346569836139679, "2109": 0.5963221788406372, "2121": ... | 1759213 | OBJECTIVE To examine the safety of using aliskiren combined with agents used to block the renin-angiotensin system. DESIGN Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES Medline, Embase, the Cochrane Library, and two trial registries, published up to 7 May 2011. STUDY SELECTION Publis... | The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis |
{"1996": 0.09495500475168228, "1998": 0.5209306478500366, "2004": 0.026976587250828743, "2005": 0.15275461971759796, "2011": 0.004870930220931768, "2035": 0.09672962874174118, "2037": 0.13071982562541962, "2048": 0.034552380442619324, "2054": 0.12556517124176025, "2075": 0.13925230503082275, "2076": 0.17431432008743286... | 1769799 | Transformation and conjugation permit the passage of DNA through the bacterial membranes and represent dominant modes for the transfer of genetic information between bacterial cells or between bacterial and eukaryotic cells. As such, they are responsible for the spread of fitness-enhancing traits, including antibiotic ... | The ins and outs of DNA transfer in bacteria. |
{"1009": 0.48670899868011475, "1011": 0.14518201351165771, "1017": 0.08154398202896118, "1043": 0.678390383720398, "1996": 0.011650617234408855, "1999": 0.006812678650021553, "2011": 0.2667117714881897, "2029": 0.04767346754670143, "2061": 0.0913962796330452, "2079": 0.34023189544677734, "2090": 0.4132472574710846, "20... | 1771079 | In the mammalian brain, astrocytes modulate neuronal function, in part, by synchronizing neuronal firing and coordinating synaptic networks. Little, however, is known about how this is accomplished from a structural standpoint. To investigate the structural basis of astrocyte-mediated neuronal synchrony and synaptic co... | Synaptic islands defined by the territory of a single astrocyte. |
{"1014": 0.3676496744155884, "1016": 0.15359249711036682, "1041": 0.32553088665008545, "1044": 0.24631060659885406, "1051": 0.026025565341114998, "2033": 0.03266380727291107, "2041": 0.3995884954929352, "2050": 0.1401015669107437, "2071": 0.3283478021621704, "2075": 0.5629584193229675, "2084": 0.24631060659885406, "208... | 1780819 | BACKGROUND Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumulating evidence suggests that the epigenome serves as the interface between the genome and the ... | Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development |
{"1014": 0.5301685929298401, "1997": 0.09761575609445572, "1999": 0.495672345161438, "2020": 0.06977381557226181, "2044": 0.1693800985813141, "2048": 0.03925827145576477, "2063": 0.21530038118362427, "2072": 0.7124901413917542, "2088": 0.17922431230545044, "2090": 0.45994341373443604, "2109": 0.39367714524269104, "2111... | 1781626 | This study examined the association between perceived control and several socioeconomic variables and self-rated health in seven post-communist countries (Russia, Estonia, Lithuania, Latvia, Hungary, Poland, Czech Republic). Questionnaire interviews were used to collect data on self-rated health in the last 12 months, ... | Socioeconomic factors, material inequalities, and perceived control in self-rated health: cross-sectional data from seven post-communist countries. |
{"1006": 0.05970508232712746, "1007": 0.10993985831737518, "1011": 0.23710809648036957, "1017": 0.6202403903007507, "1039": 0.7086513638496399, "1042": 0.02792670577764511, "1045": 0.4374985992908478, "1048": 0.15777134895324707, "1058": 0.861702561378479, "1155": 0.20102575421333313, "1999": 0.12814582884311676, "2004... | 1782201 | Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In particular, expression of integrin alpha(v)beta(3) is associated with progression of a variety of human tumors. Here we reveal a previously undescribed adhesion-independent role for integrin alpha(v)beta(3) in pancreatic cancer and o... | Integrin αvβ3/c-src “Oncogenic Unit” Promotes Anchorage-independence and Tumor Progression |
{"1011": 0.3077431619167328, "1015": 0.1401015669107437, "1016": 0.0770333781838417, "1017": 0.04487626627087593, "1038": 0.07612881064414978, "1044": 0.3923587501049042, "1048": 0.5051454305648804, "1052": 0.31204116344451904, "1997": 0.06886265426874161, "1999": 0.007782140281051397, "2007": 0.03925827145576477, "201... | 1791637 | In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 genes. To gain insight into the structure and function of bivalent domains, we mapped key histone m... | Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains |
{"1011": 0.5495203733444214, "1041": 0.43623676896095276, "1056": 0.40806588530540466, "2003": 0.083342544734478, "2029": 0.14518201351165771, "2033": 0.8731874823570251, "2043": 0.0019512200960889459, "2046": 0.3923587501049042, "2076": 0.5562619566917419, "2079": 0.0038986403960734606, "2090": 0.0174254160374403, "21... | 1791714 | Epithelial-mesenchymal transition (EMT) is implicated in converting stationary epithelial tumor cells into motile mesenchymal cells during metastasis. However, the involvement of EMT in metastasis is still controversial, due to the lack of a mesenchymal phenotype in human carcinoma metastases. Using a spontaneous squam... | Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. |
{"1017": 0.11168810725212097, "1039": 0.4537591338157654, "1040": 0.3870677351951599, "1043": 0.22157983481884003, "1044": 0.39893341064453125, "1998": 0.34508460760116577, "2004": 0.8877626657485962, "2005": 0.0354953333735466, "2008": 0.19622190296649933, "2011": 0.3106105625629425, "2015": 0.2231435477733612, "2024"... | 1797622 | Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally linked. Specifically, we show that asymmetric cell d... | Control of Apoptosis by Asymmetric Cell Division |
{"1016": 0.04394211992621422, "1039": 0.9769153594970703, "1043": 0.6446255445480347, "1060": 0.28670501708984375, "2004": 0.011650617234408855, "2007": 0.06795065850019455, "2011": 0.3084607720375061, "2029": 0.11517547070980072, "2038": 0.006812678650021553, "2076": 0.36967599391937256, "2079": 0.08513788133859634, "... | 1800734 | Upon activation, neutrophils release DNA fibers decorated with antimicrobial proteins, forming neutrophil extracellular traps (NETs). Although NETs are bactericidal and contribute to innate host defense, excessive NET formation has been linked to the pathogenesis of autoinflammatory diseases. However, the mechanisms re... | CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation |
{"1019": 0.09584271162748337, "1020": 0.5057345628738403, "1041": 0.06246116757392883, "1042": 0.06337817758321762, "1052": 0.6583697199821472, "2000": 0.11081436276435852, "2004": 0.46486347913742065, "2005": 0.306306391954422, "2007": 0.0019512200960889459, "2011": 0.14602625370025635, "2020": 0.05417001247406006, "2... | 1805641 | BACKGROUND Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and have the potential to reduce population-level transmission of the parasite. With the increased interest in malaria elimination, understanding the i... | Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity |
{"1011": 0.3897167444229126, "1013": 0.2918238639831543, "1014": 0.18573370575904846, "1041": 0.4624064862728119, "1043": 0.49626702070236206, "1045": 0.13925230503082275, "1048": 0.8450632095336914, "2004": 0.6244332790374756, "2005": 0.15442965924739838, "2011": 0.41195443272590637, "2012": 0.2969166338443756, "2013"... | 1818578 | Amino-acid producers have traditionally been developed by repeated random mutagenesis owing to the difficulty in rationally engineering the complex and highly regulated metabolic network. Here, we report the development of the genetically defined L-threonine overproducing Escherichia coli strain by systems metabolic en... | Systems metabolic engineering of Escherichia coli for L-threonine production |
{"1044": 0.07884006202220917, "1998": 0.2026219218969345, "2007": 0.29255300760269165, "2053": 0.083342544734478, "2058": 0.6181373596191406, "2089": 0.026025565341114998, "2090": 0.6338034868240356, "2094": 0.0752234235405922, "2109": 0.05139094591140747, "2111": 0.18411032855510712, "2116": 0.18654440343379974, "2119... | 1831916 | OBJECTIVE Impulsivity and inattention related to attention deficit hyperactivity disorder (ADHD) may increase food intake and, consequently, weight gain. However, findings on the association between obesity/overweight and ADHD are mixed. The authors conducted a meta-analysis to estimate this association. METHOD A broad... | Association Between ADHD and Obesity: A Systematic Review and Meta-Analysis. |
{"1045": 0.22157983481884003, "1998": 0.13071982562541962, "1999": 0.04767346754670143, "2005": 0.02412080205976963, "2007": 0.39893341064453125, "2008": 0.0038986403960734606, "2011": 0.38574060797691345, "2015": 0.15693697333335876, "2029": 0.13414156436920166, "2038": 0.006812678650021553, "2063": 0.77198725938797, ... | 1834762 | Research on the human microbiome has established that commensal and pathogenic bacteria can influence obesity, cancer, and autoimmunity through mechanisms mostly unknown. We found that a component of bacterial biofilms, the amyloid protein curli, irreversibly formed fibers with bacterial DNA during biofilm formation. T... | Amyloid-DNA Composites of Bacterial Biofilms Stimulate Autoimmunity. |
{"1043": 0.7482418417930603, "1050": 0.5827828645706177, "1056": 0.5261374711990356, "2003": 0.06246116757392883, "2029": 0.10818854719400406, "2050": 0.10906458646059036, "2064": 0.09317722171545029, "2087": 0.1710275560617447, "2099": 0.3723714053630829, "2102": 0.4974553883075714, "2179": 0.20818853378295898, "2182"... | 1836154 | Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas ( TCGA) pilot project aims to assess the value of large- scale multi- dimensional analysis of these molecular characteristics in human... | Comprehensive genomic characterization defines human glioblastoma genes and core pathways |
{"1042": 1.094698429107666, "1043": 0.4450363218784332, "1048": 0.791648268699646, "1054": 0.4734157919883728, "2003": 0.3547199070453644, "2005": 0.38574060797691345, "2100": 1.0458102226257324, "2109": 0.3723714053630829, "2135": 0.6254787445068359, "2146": 0.3084607720375061, "2229": 0.06703783571720123, "2241": 0.3... | 1840993 | Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator that represents a promising target for the treatment of several metabolic diseases. Administration of recombinant wild type FGF21 to diabetic animals leads to a dramatic improvement in glycaemia and ameliorates other systemic measures of metabolic healt... | LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys |
{"1040": 0.4190443754196167, "2003": 0.1212492436170578, "2014": 0.4158279001712799, "2064": 0.06977381557226181, "2075": 0.011650617234408855, "2076": 0.5404602885246277, "2079": 0.014542185701429844, "2083": 0.1477125883102417, "2091": 0.347847044467926, "2135": 0.26446542143821716, "2188": 0.5261374711990356, "2214"... | 1848452 | Stem cell decline is an important cellular driver of aging-associated pathophysiology in multiple tissues. Epigenetic regulation is central to establishing and maintaining stem cell function, and emerging evidence indicates that epigenetic dysregulation contributes to the altered potential of stem cells during aging. U... | Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. |
{"1039": 0.07793712615966797, "1998": 0.4444103240966797, "2005": 0.013579257763922215, "2011": 0.25845035910606384, "2012": 0.24018502235412598, "2028": 0.1734936386346817, "2029": 0.05786345899105072, "2035": 0.7295845746994019, "2048": 0.4158279001712799, "2063": 0.07068414986133575, "2064": 0.13670019805431366, "20... | 1852826 | Interactions between hosts and parasites provide an ongoing source of selection that promotes the evolution of a variety of features in the interacting species. Here, we use a genetically explicit mathematical model to explore how patterns of gene expression evolve at genetic loci responsible for host resistance and pa... | Host–Parasite Interactions and the Evolution of Gene Expression |
{"1011": 0.3560888469219208, "1015": 0.5267143249511719, "1017": 0.16359257698059082, "1039": 0.4041621685028076, "1041": 0.04113444685935974, "1045": 0.47402387857437134, "1056": 0.8861536383628845, "1155": 0.5387523174285889, "1164": 0.5051454305648804, "1597": 0.0842406153678894, "1999": 0.05970508232712746, "2007":... | 1855679 | It was recently demonstrated that interleukin (IL)-23–driven IL-17–producing (ThIL-17) T cells mediate inflammatory pathology in certain autoimmune diseases. We show that the induction of antigen-specific ThIL-17 cells, but not T helper (Th)1 or Th2 cells, by immunization with antigens and adjuvants is abrogated in IL-... | A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis |
{"1011": 0.10467668622732162, "1015": 0.3784096837043762, "1038": 0.02412080205976963, "1039": 0.6674286723136902, "2008": 0.056018441915512085, "2011": 0.2741633653640747, "2013": 0.520350456237793, "2020": 0.09228714555501938, "2028": 0.10731173306703568, "2029": 0.17020416259765625, "2050": 0.05694137513637543, "206... | 1866911 | Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary stem cell. To explore early cellular changes that occur in BRCA1 mutation carriers, we have prospectively isolated distinct epithelial subpopulations from... | Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers |
{"1011": 0.03266380727291107, "1017": 0.45251765847206116, "1043": 0.5301685929298401, "1048": 0.5472630262374878, "1050": 0.1064341589808464, "1996": 0.0770333781838417, "2000": 0.012615402229130268, "2011": 0.03831886500120163, "2025": 0.055094651877880096, "2029": 0.12470348179340363, "2048": 0.18492233753204346, "2... | 1871230 | Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require adhesion and transmigration through blood-vessel walls. The traditional three steps of rolling, activation and firm adhesion have recently been augmented and refined. Slow rolling, adhesion strengthening, intraluminal crawling and par... | Getting to the site of inflammation: the leukocyte adhesion cascade updated |
{"1011": 0.44691193103790283, "1019": 0.9929623603820801, "1022": 0.27342069149017334, "1043": 0.01934296265244484, "1044": 0.1332872211933136, "1055": 0.19782574474811554, "1059": 0.3262358605861664, "1061": 0.2184450328350067, "1156": 0.2501201331615448, "2002": 0.11430477350950241, "2011": 0.15359249711036682, "2029... | 1871499 | 5-Hydroxymethylcytosine (5-hmC) may represent a new epigenetic modification of cytosine. While the dynamics of 5-hmC during neurodevelopment have recently been reported, little is known about its genomic distribution and function(s) in neurodegenerative diseases such as Huntington's disease (HD). We here observed a mar... | Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. |
{"1037": 0.09317722171545029, "2000": 0.17840765416622162, "2003": 0.021256839856505394, "2005": 0.49686139822006226, "2044": 0.6149744987487793, "2054": 0.13157635927200317, "2055": 0.05694137513637543, "2062": 0.42608439922332764, "2079": 0.011650617234408855, "2103": 0.05786345899105072, "2110": 0.19541899859905243,... | 1886551 | The focus of this article is planning for resiliency in the aftermath of a catastrophe. First, the authors offer their conception of planning for resiliency as a goal for recovering communities, and the benefits of planning in efforts to create more resilient places. Next, they discuss major issues associated with plan... | Planning for Postdisaster Resiliency |
{"1011": 0.23015019297599792, "1020": 0.7144040465354919, "1047": 0.083342544734478, "1048": 0.38574060797691345, "1050": 1.0601204633712769, "1164": 0.5092619061470032, "2007": 0.22626367211341858, "2020": 0.006812678650021553, "2029": 0.27342069149017334, "2044": 0.28155985474586487, "2076": 0.18329764902591705, "207... | 1887056 | OBJECTIVE The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress. METHOD Plasma interleukin (IL)-6, lymphocyte subsets, and DNA binding of nuclear factor (NF)-kB in peripheral blood mononuclear cells were compared i... | Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. |
{"1011": 0.13157635927200317, "1017": 0.5784112811088562, "1038": 0.19782574474811554, "1043": 0.4679262638092041, "1047": 0.5483922958374023, "1999": 0.1477125883102417, "2004": 0.021256839856505394, "2007": 0.3248254358768463, "2008": 0.06703783571720123, "2011": 0.4938860833644867, "2029": 0.30989447236061096, "2033... | 1889358 | We cloned a new member of the murine brain kinesin superfamily, KIF3B, and found that its amino acid sequence is highly homologous but not identical to KIF3A, which we previously cloned and named KIF3 (47% identical). KIF3B is localized in various organ tissues and developing neurons of mice and accumulates with antero... | KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport |
{"1011": 0.38905516266822815, "1015": 0.2478361576795578, "1047": 0.07612881064414978, "1048": 0.7647408246994019, "1061": 0.3949938118457794, "1996": 0.2837681770324707, "1998": 0.1332872211933136, "2003": 0.3019835948944092, "2008": 0.05694137513637543, "2025": 0.39433568716049194, "2029": 0.22548456490039825, "2072"... | 1897324 | The Hippo–YAP pathway is an emerging signalling cascade involved in the regulation of stem cell activity and organ size. To identify components of this pathway, we performed an RNAi-based kinome screen in human cells. Our screen identified several kinases not previously associated with Hippo signalling that control mul... | A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway |
{"1011": 0.16690383851528168, "1015": 0.6410312056541443, "1040": 0.17020416259765625, "1048": 0.5898461937904358, "1052": 0.3269403576850891, "2003": 0.13499516248703003, "2005": 0.41195443272590637, "2028": 0.2637155055999756, "2029": 0.004870930220931768, "2038": 0.10818854719400406, "2042": 0.10818854719400406, "20... | 1900152 | Immune checkpoint inhibitors have been identified as breakthrough treatment in melanoma given its dramatic response to PD-1/PD-L1 blockade. This is likely to extend to many other cancers as hundreds of clinical trials are being conducted or proposed using this exciting modality of therapy in a variety of malignancies. ... | Beyond melanoma: inhibiting the PD-1/PD-L1 pathway in solid tumors. |
{"1017": 0.678390383720398, "1043": 0.07341018319129944, "1044": 0.7898768186569214, "1997": 0.2089812457561493, "2015": 0.12814582884311676, "2020": 0.03360854089260101, "2029": 0.0038986403960734606, "2041": 0.24325250089168549, "2048": 0.33605360984802246, "2072": 0.20102575421333313, "2093": 0.9568626880645752, "21... | 1904291 | The allocation of hypoglycaemic symptoms to autonomie or neuroglycopenic groups tends to occur on an a priori basis. In view of the practical need for clear symptom markers of hypoglycaemia more scientific approaches must be pursued. Substantial evidence is presented from two large scale studies we performed which supp... | Partitioning the symptoms of hypoglycaemia using multi-sample confirmatory factor analysis |
{"1011": 0.2637155055999756, "1014": 0.0752234235405922, "1039": 0.14433705806732178, "1041": 0.09850110858678818, "1048": 0.21293537318706512, "1052": 0.3077431619167328, "1081": 0.8383291959762573, "1999": 0.06246116757392883, "2004": 0.06703783571720123, "2007": 0.026025565341114998, "2011": 0.5596157908439636, "201... | 1905095 | AIMS Recent evidence suggests that cardiac progenitor cells (CPCs) may improve cardiac function after injury. The underlying mechanisms are indirect, but their mediators remain unidentified. Exosomes and other secreted membrane vesicles, hereafter collectively referred to as extracellular vesicles (EVs), act as paracri... | Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction. |
{"1011": 0.1889725625514984, "1015": 0.6654226183891296, "1042": 0.176772341132164, "1044": 0.8608771562576294, "1998": 0.22937409579753876, "2002": 0.23402166366577148, "2028": 0.2160874605178833, "2058": 0.3656192123889923, "2064": 0.08154398202896118, "2076": 0.1734936386346817, "2080": 0.056018441915512085, "2094":... | 1907601 | Adipose tissue hypoxia and inflammation have been causally implicated in obesity-induced insulin resistance. Here, we report that, early in the course of high-fat diet (HFD) feeding and obesity, adipocyte respiration becomes uncoupled, leading to increased oxygen consumption and a state of relative adipocyte hypoxia. T... | Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity |
{"1017": 0.43244171142578125, "1048": 0.5086748600006104, "1052": 0.40285754203796387, "1056": 0.9769153594970703, "1058": 0.9915141463279724, "1999": 0.19622190296649933, "2002": 0.3464667797088623, "2004": 0.011650617234408855, "2015": 0.817850649356842, "2029": 0.22001366317272186, "2033": 0.5324648022651672, "2046"... | 1910120 | The role of specific phospholipids (PLs) in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo. Here we show that the phospholipid remodeling enzyme lysophosphatidylcholine acyltransferase 3 (Lpcat3) is a critical determinant of triglyceride (TG) secr... | Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion |
{"1011": 0.21765978634357452, "1038": 0.26296505331993103, "1081": 0.32270604372024536, "1997": 0.0019512200960889459, "1999": 0.018384648486971855, "2003": 0.07612881064414978, "2005": 0.21135559678077698, "2011": 0.13499516248703003, "2028": 0.14179791510105133, "2029": 0.13499516248703003, "2034": 0.0411344468593597... | 1914588 | Single-stranded DNA-binding protein (SSB) plays an important role in DNA metabolism, such as in DNA replication, repair, and recombination, and is essential for cell survival. We characterized the single-stranded DNA (ssDNA)-binding properties of Pseudomonas aeruginosa PAO1 SSB (PaSSB) by using fluorescence quenching m... | Characterization of a single-stranded DNA-binding protein from Pseudomonas aeruginosa PAO1. |
{"1039": 0.304147332906723, "1996": 0.36900100111961365, "1999": 0.007782140281051397, "2003": 0.20818853378295898, "2008": 0.12986256182193756, "2024": 0.4158279001712799, "2029": 0.036437395960092545, "2076": 0.3339579105377197, "2079": 0.4568560719490051, "2109": 0.05970508232712746, "2112": 0.06154331564903259, "21... | 1917068 | Primary cilia are microtubule-based sensory organelles that coordinate signalling pathways in cell-cycle control, migration, differentiation and other cellular processes critical during development and for tissue homeostasis. Accordingly, defects in assembly or function of primary cilia lead to a plethora of developmen... | Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling. |
{"1054": 0.18004031479358673, "2000": 0.06977381557226181, "2003": 0.05786345899105072, "2011": 0.015504186972975731, "2020": 0.04767346754670143, "2047": 0.010684899985790253, "2052": 0.25694093108177185, "2064": 0.09317722171545029, "2067": 0.1401015669107437, "2071": 0.2231435477733612, "2077": 0.22937409579753876, ... | 1921218 | Tumor recurrence represents a major clinical challenge. Our data show that emergent recurrent tumors acquire a phenotype radically different from that of their originating primary tumors. This phenotype allows them to evade a host-derived innate immune response elicited by the progression from minimal residual disease ... | Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence |
{"1011": 0.06612417846918106, "2011": 0.3297532796859741, "2026": 0.7295845746994019, "2029": 0.014542185701429844, "2033": 0.5069117546081543, "2037": 0.06246116757392883, "2043": 0.021256839856505394, "2048": 0.4002431631088257, "2070": 0.05970508232712746, "2075": 0.4500300884246826, "2076": 0.5871354341506958, "207... | 1922901 | During development, mechanical forces cause changes in size, shape, number, position, and gene expression of cells. They are therefore integral to any morphogenetic processes. Force generation by actin-myosin networks and force transmission through adhesive complexes are two self-organizing phenomena driving tissue mor... | Forces in Tissue Morphogenesis and Patterning |
{"1009": 0.4752389192581177, "1015": 0.2447827309370041, "1043": 0.40806588530540466, "1048": 0.24554696679115295, "1056": 1.0151457786560059, "2003": 0.1064341589808464, "2005": 0.037378571927547455, "2008": 0.025073638185858727, "2011": 0.2749055027961731, "2024": 0.28082266449928284, "2029": 0.2026219218969345, "207... | 1933281 | Invariant natural killer T cells (iNKT cells) are involved in the host defense against microbial infection. Although it is known that iNKT cells recognize glycolipids presented by CD1d, how and where they encounter antigen in vivo remains unclear. Here we used multiphoton microscopy to visualize the dynamics and activa... | CD169+ MACROPHAGES PRESENT LIPID ANTIGENS TO MEDIATE EARLY ACTIVATION OF INVARIANT NKT CELLS IN LYMPH NODES |
{"1011": 0.06429435312747955, "1015": 0.20501139760017395, "1051": 0.19622190296649933, "2002": 0.03925827145576477, "2008": 0.0174254160374403, "2010": 0.7124901413917542, "2011": 0.2667117714881897, "2029": 0.24018502235412598, "2035": 0.07431721687316895, "2038": 0.05694137513637543, "2058": 0.5450005531311035, "206... | 1941721 | Cells deficient in a major DNA double-strand break repair pathway (nonhomologous DNA end joining [NHEJ]) have increased spontaneous chromosome breaks; however, the source of these chromosome breaks has remained undefined. Here, we show that the observed spontaneous chromosome breaks are partially suppressed by reducing... | Oxygen Metabolism Causes Chromosome Breaks and Is Associated with the Neuronal Apoptosis Observed in DNA Double-Strand Break Repair Mutants |
{"1044": 0.15693697333335876, "2002": 0.2667117714881897, "2006": 0.14179791510105133, "2011": 0.2983669638633728, "2033": 0.562402069568634, "2046": 0.5930894017219543, "2047": 0.1485546976327896, "2064": 0.15610189735889435, "2071": 0.10203468054533005, "2079": 0.129004567861557, "2089": 0.23787821829319, "2097": 0.0... | 1944452 | PURPOSE OF REVIEW Recent preclinical and clinical studies revealed that the semirandom insertion of transgenes into chromosomal DNA of hematopoietic cells may induce clonal competition, which potentially may even trigger leukemia or sarcoma. Insertional mutagenesis caused by gene vectors has thus led to major uncertain... | Insertional mutagenesis in gene therapy and stem cell biology. |
{"1003": 0.09672962874174118, "1014": 0.6563454270362854, "1017": 0.16442140936851501, "2000": 0.03266380727291107, "2001": 0.22782009840011597, "2005": 0.07431721687316895, "2009": 0.7701805830001831, "2011": 0.14264501631259918, "2013": 0.06337817758321762, "2020": 0.25845035910606384, "2035": 0.23864774405956268, "2... | 1946610 | BACKGROUND Tanzania has a well-developed network of commercial ITN retailers. In 2004, the government introduced a voucher subsidy for pregnant women and, in mid 2005, helped distribute free nets to under-fives in small number of districts, including Rufiji on the southern coast, during a child health campaign. Contrib... | Markets, voucher subsidies and free nets combine to achieve high bed net coverage in rural Tanzania |
{"1015": 0.31132611632347107, "1039": 0.07884006202220917, "1043": 0.2105647772550583, "1044": 0.6471850275993347, "2002": 0.055094651877880096, "2028": 0.02792670577764511, "2029": 0.28963330388069153, "2039": 0.06703783571720123, "2043": 0.4812922179698944, "2062": 0.18492233753204346, "2076": 0.20580662786960602, "2... | 1958440 | A total of 527 blood samples was obtained from an unselected population of women between 36 and 40 weeks gestation. Serum human chorionic gonadotropin (hCG) levels were measured using a specific radioimmunoassay for the beta 1-subunit of hCG. Serum hCG levels were higher in primigravidae and in women carrying female fe... | Human chorionic gonadotropin levels in maternal blood in late pregnancy: relation to birthweight, sex and condition of the infant at birth. |
{"1011": 0.27786844968795776, "1016": 0.2447827309370041, "1038": 0.5267143249511719, "1049": 0.659380316734314, "1055": 0.42353010177612305, "2008": 0.0038986403960734606, "2011": 0.2622140049934387, "2026": 0.30989447236061096, "2029": 0.14264501631259918, "2033": 1.2347444295883179, "2066": 0.4481603503227234, "2078... | 1964163 | Mutations or duplications in MECP2 cause Rett and Rett-like syndromes, neurodevelopmental disorders characterized by mental retardation, motor dysfunction, and autistic behaviors. MeCP2 is expressed in many mammalian tissues and functions as a global repressor of transcription; however, the molecular mechanisms by whic... | Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation |
{"1015": 0.20022670924663544, "1019": 0.056018441915512085, "1021": 0.4794800877571106, "1022": 0.5640701055526733, "1037": 0.5612884759902954, "1038": 0.7764897346496582, "1039": 0.7333439588546753, "1054": 0.5941681861877441, "2028": 0.006812678650021553, "2029": 0.17759032547473907, "2035": 0.8649974465370178, "2084... | 1967017 | Correction for: Kurreeman FAS, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, et al. (2007) A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis. PLoS Med 4(9): e278. doi:10.1371/journal.pmed.0040278 In Table 1, the allele ratio in column eight (Allele Ratiosb: C... | A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis |
{"1011": 0.18411032855510712, "1016": 0.13755162060260773, "1043": 0.2231435477733612, "1157": 0.9021284580230713, "1998": 0.05139094591140747, "2005": 0.18492233753204346, "2008": 0.10555581003427505, "2015": 0.13157635927200317, "2029": 0.1710275560617447, "2045": 0.23247487843036652, "2048": 0.6107416749000549, "206... | 1967410 | Although significant progress has occurred in the past 20 years regarding our understanding of Alzheimer disease pathogenesis, we have yet to identify disease-modifying therapeutics capable of substantially altering the clinical course of this prevalent neurodegenerative disease. In this short review, we discuss 2 appr... | Potential use of γ-secretase modulators in the treatment of Alzheimer disease. |
{"1005": 0.30558720231056213, "1011": 0.2741633653640747, "1016": 0.7267557382583618, "1019": 0.11778303235769272, "1021": 0.6400018334388733, "1046": 0.25467249751091003, "1049": 0.0913962796330452, "1050": 0.5707147121429443, "1051": 0.7445381283760071, "1997": 0.07068414986133575, "1999": 0.08154398202896118, "2000"... | 1970884 | Viruses that replicate in the cytoplasm cannot access the host nuclear capping machinery. These viruses have evolved viral methyltransferase(s) to methylate N-7 and 2'-O cap of their RNA; alternatively, they "snatch" host mRNA cap to form the 5' end of viral RNA. The function of 2'-O methylation of viral RNA cap is to ... | Rational design of a flavivirus vaccine by abolishing viral RNA 2'-O methylation. |
{"1014": 0.4349733293056488, "1016": 0.8764448165893555, "1057": 0.07341018319129944, "2005": 0.018384648486971855, "2015": 0.18004031479358673, "2029": 0.05046287178993225, "2039": 0.026976587250828743, "2048": 0.3923587501049042, "2064": 0.11256109178066254, "2090": 0.2018241584300995, "2093": 0.1401015669107437, "21... | 1974176 | OBJECTIVE To determine whether individual fruits are differentially associated with risk of type 2 diabetes. DESIGN Prospective longitudinal cohort study. SETTING Health professionals in the United States. PARTICIPANTS 66,105 women from the Nurses' Health Study (1984-2008), 85,104 women from the Nurses' Health Study II... | Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies |
{"1011": 0.4518963396549225, "1014": 0.1751343309879303, "1023": 0.23015019297599792, "1038": 0.034552380442619324, "1046": 0.3297532796859741, "1048": 0.7201237678527832, "1049": 0.1718502640724182, "1052": 0.3443928062915802, "1053": 0.5370414853096008, "2005": 0.23710809648036957, "2007": 0.022212404757738113, "2011... | 1976183 | BACKGROUND MicroRNA-196 (miR-196), which is highly up-regulated in oral cancer cells, has been reported to be aberrantly expressed in several cancers; however, the significance of miR-196 in oral cancer has not yet been addressed. METHODS Cellular functions in response to miR-196 modulation were examined, including cel... | OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway |
{"1011": 0.4067663550376892, "1015": 0.43053874373435974, "1017": 0.38905516266822815, "1048": 0.45994341373443604, "1056": 1.004473328590393, "1060": 0.2689530849456787, "1998": 0.22392450273036957, "2006": 0.8022117614746094, "2011": 0.2667117714881897, "2012": 0.08961215615272522, "2028": 0.1889725625514984, "2029":... | 1982286 | The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to decipher the oncogenic regulatory circuit controlled by TLX1 and TLX3. This systems biology analysis defined T cell ... | Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL |
{"1009": 0.1994270235300064, "1039": 0.02792670577764511, "1044": 0.42735910415649414, "1085": 0.4067663550376892, "2000": 0.25995752215385437, "2005": 0.012615402229130268, "2006": 0.07068414986133575, "2012": 0.14349138736724854, "2022": 0.151916041970253, "2034": 0.10731173306703568, "2040": 0.9515975713729858, "204... | 1986482 | BACKGROUND Since November 2009, WHO recommends that adults infected with HIV should initiate antiretroviral therapy (ART) at CD4+ cell counts of ≤350 cells/µl rather than ≤200 cells/µl. South Africa decided to adopt this strategy for pregnant and TB co-infected patients only. We estimated the impact of fully adopting t... | The Impact of the New WHO Antiretroviral Treatment Guidelines on HIV Epidemic Dynamics and Cost in South Africa |
{"1011": 0.24325250089168549, "1015": 0.23710809648036957, "1996": 0.18248429894447327, "1998": 0.11256109178066254, "2005": 0.16442140936851501, "2007": 0.1477125883102417, "2029": 0.13670019805431366, "2046": 0.2954642176628113, "2047": 0.0029254043474793434, "2048": 0.09672962874174118, "2073": 0.083342544734478, "2... | 1991105 | Mitochondrial division is important for mitochondrial distribution and function. Recent data have demonstrated that ER-mitochondria contacts mark mitochondrial division sites, but the molecular basis and functions of these contacts are not understood. Here we show that in yeast, the ER-mitochondria tethering complex, E... | ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast |
{"1011": 0.42990362644195557, "1014": 0.5718178153038025, "1015": 0.848413348197937, "1026": 0.2089812457561493, "1038": 1.0030416250228882, "1039": 0.15442965924739838, "1045": 0.03831886500120163, "1052": 0.36967599391937256, "1056": 0.040196798741817474, "1081": 0.7665573358535767, "2004": 0.3956514894962311, "2007"... | 1996292 | BMI-1 is overexpressed in a variety of cancers, which can elicit an immune response leading to the induction of autoantibodies. However, BMI-1 autoantibody as a biomarker has seldom been studied with the exception of nasopharyngeal carcinoma. Whether BMI-1 autoantibodies can be used as a biomarker for cervical carcinom... | BMI-1 Autoantibody as a New Potential Biomarker for Cervical Carcinoma |
{"1011": 0.025073638185858727, "1037": 0.02316705882549286, "1996": 0.013579257763922215, "2003": 0.2881702482700348, "2008": 0.28082266449928284, "2011": 0.31845372915267944, "2015": 0.40806588530540466, "2024": 0.4950772523880005, "2029": 0.07341018319129944, "2050": 0.19381128251552582, "2054": 0.11430477350950241, ... | 2000038 | MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and flow cytometry to monitor a target gene's protein expression in the presence and absence of regulation ... | MicroRNAs can generate thresholds in target gene expression |
{"1011": 0.151916041970253, "1039": 0.27044451236724854, "1042": 0.26296505331993103, "1043": 0.6684301495552063, "1049": 0.10906458646059036, "1060": 0.5729197263717651, "2006": 0.450652539730072, "2011": 0.04860413447022438, "2015": 0.4891071021556854, "2026": 0.9798521995544434, "2029": 0.0029254043474793434, "2033"... | 2014909 | Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanisms governing such heterogeneity are largely unknown. Here, integrating human tumour genomics and synge... | Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation |
{"1015": 0.43434104323387146, "1016": 0.49864232540130615, "1038": 0.02792670577764511, "1051": 0.43623676896095276, "1998": 0.029824240133166313, "2000": 0.4067663550376892, "2005": 0.17840765416622162, "2007": 0.25694093108177185, "2012": 0.45499902963638306, "2014": 0.0174254160374403, "2028": 0.12814582884311676, "... | 2015126 | The management of women who have a genetic predisposition for breast cancer requires careful planning. Women who have BRCA 1 and BRCA 2 mutations are at increased risk for breast cancer and for other cancers as well, particularly ovarian cancer. Screening, prophlyactic surgery, and chemoprevention are commonly utilized... | Management of women who have a genetic predisposition for breast cancer. |
{"1011": 0.07250232994556427, "1015": 0.1384023278951645, "1042": 0.5990082025527954, "1048": 0.6275664567947388, "1051": 0.27934664487838745, "1055": 0.1970241367816925, "2003": 0.2830325961112976, "2012": 0.055094651877880096, "2013": 0.03266380727291107, "2015": 0.6970458030700684, "2029": 0.1485546976327896, "2054"... | 2015929 | Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease, with astrocytes implicated as contributing substantially to motor neuron death in familial (F)ALS. However, the proposed role of astrocytes in the pathology of ALS derives in part from rodent models of FALS based upon dominant mutations within the sup... | Astrocytes from Familial and Sporadic ALS Patients are Toxic to Motor Neurons |
{"1014": 0.16690383851528168, "1020": 0.10906458646059036, "1044": 0.6543170213699341, "1049": 0.10203468054533005, "1052": 0.2659635543823242, "1060": 0.22001366317272186, "1998": 0.12038381397724152, "2005": 0.19782574474811554, "2019": 0.5685047507286072, "2020": 0.02412080205976963, "2038": 0.007782140281051397, "2... | 2028532 | The aims of this randomised controlled trial were to determine if a high-intensity functional exercise program improves balance, gait ability, and lower-limb strength in older persons dependent in activities of daily living and if an intake of protein-enriched energy supplement immediately after the exercises increases... | High-intensity functional exercise program and protein-enriched energy supplement for older persons dependent in activities of daily living: a randomised controlled trial. |
{"1011": 0.3106105625629425, "1042": 0.37102460861206055, "1056": 0.7610978484153748, "1999": 0.14433705806732178, "2011": 0.25088030099868774, "2026": 0.8965662121772766, "2037": 0.07612881064414978, "2039": 0.32764431834220886, "2079": 0.22782009840011597, "2080": 0.9425065517425537, "2109": 0.3824150264263153, "2114... | 2030623 | Myeloid-derived suppressor cells (MDSC) promote tumor growth by inhibiting T-cell immunity and promoting malignant cell proliferation and migration. The therapeutic potential of blocking MDSC in tumors has been limited by their heterogeneity, plasticity, and resistance to various chemotherapy agents. Recent studies hav... | Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies |
{"1011": 0.026976587250828743, "1044": 0.5925496220588684, "1051": 0.0842406153678894, "1052": 0.5278670787811279, "1054": 0.5450005531311035, "1164": 0.08064348995685577, "1997": 0.10906458646059036, "2001": 0.08244366943836212, "2007": 0.1734936386346817, "2012": 0.129004567861557, "2020": 0.07612881064414978, "2034"... | 2032877 | PURPOSE To identify factors affecting the short-term prognosis of patients with acutely exacerbated chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS The 590 patients having COPD as primary disease who were hospitalized in the pneumology unit of a university hospital from 1981 to 1990 were studied. A s... | Predicting mortality of patients hospitalized for acutely exacerbated chronic obstructive pulmonary disease. |
{"1050": 0.34508460760116577, "1996": 0.010684899985790253, "1999": 0.15442965924739838, "2005": 0.151916041970253, "2011": 0.34370049834251404, "2012": 0.18978065252304077, "2029": 0.11430477350950241, "2038": 0.04487626627087593, "2043": 0.11865071207284927, "2073": 0.14939609169960022, "2076": 0.6233867406845093, "2... | 2033917 | Clathrin has an established function in the generation of vesicles that transfer membrane and proteins around the cell. The formation of clathrin-coated vesicles occurs continuously in non-dividing cells, but is shut down during mitosis, when clathrin concentrates at the spindle apparatus. Here, we show that clathrin s... | Clathrin is required for the function of the mitotic spindle |
{"1009": 0.2763880789279938, "1011": 0.17840765416622162, "1014": 0.04860413447022438, "1016": 0.12814582884311676, "1017": 0.36494144797325134, "1018": 0.3409265875816345, "1019": 0.1011524572968483, "1043": 0.8600510358810425, "1051": 0.02316705882549286, "1996": 0.012615402229130268, "1999": 0.3519764244556427, "200... | 2039912 | Basal extracellular glutamate sampled in vivo is present in micromolar concentrations in the extracellular space outside the synaptic cleft, and neither the origin nor the function of this glutamate is known. This report reveals that blockade of glutamate release from the cystine-glutamate antiporter produced a signifi... | The origin and neuronal function of in vivo nonsynaptic glutamate. |
{"1011": 0.5174443125724792, "1015": 0.5540198087692261, "1045": 0.3662964701652527, "1048": 0.5238267183303833, "1056": 0.36967599391937256, "2003": 0.11604541540145874, "2005": 0.22626367211341858, "2008": 0.0009760859538801014, "2011": 0.4196864068508148, "2012": 0.2837681770324707, "2028": 0.2749055027961731, "2029... | 2042250 | Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (TH2) c... | Disease-associated functions of IL-33: the new kid in the IL-1 family |
{"1003": 0.055094651877880096, "1006": 0.037378571927547455, "1009": 0.7009293437004089, "1011": 0.1873544454574585, "1014": 0.46363574266433716, "1039": 0.7408206462860107, "1044": 0.12038381397724152, "1998": 0.04674193635582924, "2002": 0.9987343549728394, "2005": 0.13755162060260773, "2007": 0.5209306478500366, "20... | 2048139 | BackgroundIndividuals with substance use disorders (SUDs) are at increased risk for hepatitis C viral infection (HCV), and few studies have explored their treatment responses empirically. The objective of this study was to assess interferon alpha therapy (IFN) completion and response rates among patients with HCV who h... | Interferon alpha therapy for hepatitis C: treatment completion and response rates among patients with substance use disorders |
{"1013": 0.11343330889940262, "1014": 0.0842406153678894, "1043": 0.056018441915512085, "1044": 0.7728893756866455, "1045": 0.8682814836502075, "1052": 0.8997484445571899, "1999": 0.004870930220931768, "2002": 0.8583967685699463, "2007": 0.28670501708984375, "2029": 0.06520967930555344, "2072": 0.04113444685935974, "20... | 2052720 | OBJECTIVE To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than ... | Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. |
{"1017": 0.23324857652187347, "1020": 0.5568217039108276, "1042": 0.44566190242767334, "1047": 0.5920094847679138, "1049": 0.6128603219985962, "1051": 0.7047978043556213, "1998": 0.25845035910606384, "2006": 0.8715548515319824, "2007": 0.12986256182193756, "2008": 0.10467668622732162, "2011": 0.19381128251552582, "2012... | 2053540 | Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are members of the interleukin-6 (IL-6) subfamily of cytokines that use a common signal transducer gp130. Human OSM (hOSM) and LIF share a functional high-affinity receptor that is composed of gp130 and LIF receptor beta subunit (LIFRbeta). A second high-affinity ... | Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice. |
{"100": 0.2652147710323334, "1011": 0.6064908504486084, "1016": 0.4481603503227234, "1050": 0.31204116344451904, "1054": 0.04487626627087593, "1166": 0.08961215615272522, "2003": 0.037378571927547455, "2012": 0.33115679025650024, "2029": 0.11865071207284927, "2051": 0.57457035779953, "2058": 0.007782140281051397, "2099... | 2056197 | In vivo real-time epifluorescence imaging of mouse hind limb vasculatures in the second near-infrared region (NIR-II) is performed using single-walled carbon nanotubes as fluorophores. Both high spatial (∼30 μm) and temporal (<200 ms per frame) resolution for small-vessel imaging are achieved at 1–3 mm deep in the hind... | Multifunctional in vivo vascular imaging using near-infrared II fluorescence |
{"1019": 0.13670019805431366, "1023": 0.18329764902591705, "1053": 0.10906458646059036, "1998": 0.1970241367816925, "2001": 0.21687394380569458, "2020": 0.0770333781838417, "2034": 0.38441169261932373, "2039": 0.23633737862110138, "2043": 0.26446542143821716, "2044": 0.25467249751091003, "2045": 0.0913962796330452, "20... | 2058909 | UNLABELLED The objective of this study was to examine differences in cancer survival between socioeconomic groups in England, with particular attention to survival in the short term of follow-up. PATIENTS AND METHODS Individuals diagnosed with colorectal cancer between 1996 and 2004 in England were identified from canc... | Colorectal cancer survival in socioeconomic groups in England: variation is mainly in the short term after diagnosis. |
{"1011": 0.319873183965683, "1050": 0.6862877607345581, "1998": 0.03266380727291107, "2000": 0.7276995778083801, "2004": 0.15860503911972046, "2011": 0.4318077862262726, "2015": 0.27786844968795776, "2026": 0.9546096324920654, "2029": 0.07250232994556427, "2033": 0.8853482007980347, "2079": 0.13414156436920166, "2090":... | 2060137 | Cell-to-cell adhesions are crucial in maintaining the structural and functional integrity of cardiac cells. Little is known about the mechanosensitivity and mechanotransduction of cell-to-cell interactions. Most studies of cardiac mechanotransduction and myofibrillogenesis have focused on cell-extracellular matrix (ECM... | Cardiac myocyte remodeling mediated by N-cadherin-dependent mechanosensing. |
{"1011": 0.04674193635582924, "1015": 0.49864232540130615, "1051": 0.21687394380569458, "2002": 0.66441810131073, "2006": 0.040196798741817474, "2028": 0.3499138653278351, "2029": 0.40741631388664246, "2038": 0.08782484382390976, "2058": 0.854249119758606, "2091": 0.8238670229911804, "2146": 0.1970241367816925, "2152":... | 2061878 | Aberrant overexpression of the long non-coding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) has been documented in different types of solid tumours, such as lung cancer, oesophageal cancer, colorectal cancer and hepatocellular carcinoma, in which its high levels are associated with poor prognosis. In contrast,... | NEAT1: A novel cancer‐related long non‐coding RNA |
{"1011": 0.24401791393756866, "1050": 0.6011518239974976, "1056": 0.06703783571720123, "2004": 0.056018441915512085, "2015": 0.5483922958374023, "2025": 0.39762192964553833, "2029": 0.0038986403960734606, "2038": 0.13071982562541962, "2042": 0.08064348995685577, "2053": 0.7370892763137817, "2064": 0.014542185701429844,... | 2062382 | The popularization of genome-wide analyses and RNA sequencing led to the discovery that a large part of the human genome, while effectively transcribed, does not encode proteins. Long non-coding RNAs have emerged as critical regulators of gene expression in both normal and disease states. Studies of long non-coding RNA... | The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease |
{"1011": 0.21293537318706512, "1018": 0.8600510358810425, "1051": 0.12728634476661682, "2003": 0.347847044467926, "2005": 0.18167030811309814, "2008": 0.1619328260421753, "2029": 0.2637155055999756, "2033": 0.7629209756851196, "2061": 0.6223390698432922, "2079": 0.1602703034877777, "2092": 0.3262358605861664, "2109": 0... | 2078658 | Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming. However, limited information is available on Oct4-associated protein complexes and their intrinsic protein-protein interactions that dictate Oct4's critical regulatory activiti... | Oct4 links multiple epigenetic pathways to the pluripotency network |
{"1011": 0.0770333781838417, "1015": 0.3601844012737274, "1016": 0.10818854719400406, "1017": 0.40611594915390015, "1019": 0.8877626657485962, "1056": 0.33953672647476196, "1996": 0.07068414986133575, "1999": 0.030771657824516296, "2007": 0.09672962874174118, "2012": 0.10203468054533005, "2028": 0.14264501631259918, "2... | 2086909 | The Tet family of enzymes (Tet1/2/3) converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Mouse embryonic stem cells (mESCs) highly express Tet1 and have an elevated level of 5hmC. Tet1 has been implicated in ESC maintenance and lineage specification in vitro but its precise function in development is not... | Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. |
{"1011": 0.004870930220931768, "1014": 0.2539152204990387, "1021": 0.08154398202896118, "1048": 0.42353010177612305, "1052": 0.5635144114494324, "1055": 0.637939989566803, "2007": 0.1685553640127182, "2013": 0.04394211992621422, "2015": 0.12986256182193756, "2029": 0.05139094591140747, "2035": 0.2719337046146393, "2038... | 2095573 | BACKGROUND LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic targets. We therefore did a genome-wide association study of LDL-choleste... | LDL-cholesterol concentrations: a genome-wide association study |
{"1044": 0.09584271162748337, "1999": 0.06977381557226181, "2000": 0.034552380442619324, "2001": 0.022212404757738113, "2012": 0.20977331697940826, "2013": 0.045809537172317505, "2015": 0.13755162060260773, "2025": 0.12038381397724152, "2052": 0.15860503911972046, "2058": 0.034552380442619324, "2062": 0.041134446859359... | 2097256 | BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We analysed the interaction between human population density and lack of tap water as a cause of dengue fever outbreak... | Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis |
{"1041": 0.11604541540145874, "1043": 0.04207121208310127, "1044": 0.8674615025520325, "1048": 0.018384648486971855, "1052": 0.9805850982666016, "1996": 0.2786078155040741, "1999": 0.043007105588912964, "2002": 1.034073829650879, "2008": 0.04207121208310127, "2011": 0.0842406153678894, "2015": 0.02792670577764511, "202... | 2099400 | Helicobacter pylori induces motogenic and cytoskeletal responses in gastric epithelial cells. We demonstrate that these responses can be induced via independent signaling pathways that often occur in parallel. The cag pathogenicity island appears to be nonessential for induction of motility, whereas the elongation phen... | Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways. |
{"1011": 0.030771657824516296, "1055": 0.1384023278951645, "2003": 0.2719337046146393, "2005": 0.015504186972975731, "2054": 0.3870677351951599, "2109": 0.23787821829319, "2114": 0.0174254160374403, "2146": 0.30917787551879883, "2207": 0.32129061222076416, "2385": 0.17020416259765625, "2460": 0.5290185213088989, "2490"... | 2107238 | SUMMARY The Sequence Alignment/Map (SAM) format is a generic alignment format for storing read alignments against reference sequences, supporting short and long reads (up to 128 Mbp) produced by different sequencing platforms. It is flexible in style, compact in size, efficient in random access and is the format in whi... | The Sequence Alignment/Map format and SAMtools |
{"1011": 0.13925230503082275, "1013": 0.2184450328350067, "1016": 0.34370049834251404, "1017": 0.7408206462860107, "1997": 0.13499516248703003, "2005": 0.07612881064414978, "2007": 0.0019512200960889459, "2008": 0.02792670577764511, "2011": 0.4349733293056488, "2029": 0.35334911942481995, "2046": 0.17922431230545044, "... | 2119889 | Polymerization of actin filaments directed by the actin-related protein (Arp)2/3 complex supports many types of cellular movements. However, questions remain regarding the relative contributions of Arp2/3 complex versus other mechanisms of actin filament nucleation to processes such as path finding by neuronal growth c... | Characterization of two classes of small molecule inhibitors of Arp2/3 complex |
{"1013": 0.10203468054533005, "1017": 0.6838265657424927, "1019": 0.18654440343379974, "1040": 0.22782009840011597, "1047": 0.659380316734314, "1052": 0.47463157773017883, "1056": 0.1229778528213501, "1996": 0.09495500475168228, "1997": 0.27044451236724854, "2011": 0.19862671196460724, "2012": 0.0009760859538801014, "2... | 2121272 | Recent technological improvements in the elastic substrate method make it possible to produce spatially resolved measurements of the tractions exerted by single motile cells. In this study we have applied these developments to produce maps of the tractions exerted by 3T3 fibroblasts during steady locomotion. The result... | Stresses at the cell-to-substrate interface during locomotion of fibroblasts |
{"1011": 0.2145126610994339, "1020": 0.8264343738555908, "1048": 0.45251765847206116, "1999": 0.0752234235405922, "2007": 0.5795059204101562, "2011": 0.25239890813827515, "2029": 0.1229778528213501, "2048": 0.22079704701900482, "2050": 0.6075552701950073, "2058": 0.31489628553390503, "2064": 0.004870930220931768, "2078... | 2130391 | Early local tumor invasion in breast cancer results in a likely encounter between cancer cells and mature adipocytes, but the role of these fat cells in tumor progression remains unclear. We show that murine and human tumor cells cocultivated with mature adipocytes exhibit increased invasive capacities in vitro and in ... | Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. |
{"1014": 0.32905077934265137, "1039": 0.3601844012737274, "1040": 0.15943801403045654, "1044": 0.27786844968795776, "1058": 0.24248650670051575, "1609": 0.5307431221008301, "2007": 0.10203468054533005, "2058": 0.512191891670227, "2085": 0.4891071021556854, "2087": 0.3615458607673645, "2094": 0.9394577741622925, "2108":... | 2138767 | AIMS Cardiovascular disease (CVD) is now the most prevalent and debilitating disease affecting the Chinese population. The goal of the present manuscript was to analyse cardiovascular risk factors and the prevalence of non-fatal CVDs from data gathered from the 2007-2008 China National Diabetes and Metabolic Disorders ... | Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study. |
{"1015": 0.4709797203540802, "1016": 0.5290185213088989, "1017": 0.15610189735889435, "1040": 0.034552380442619324, "1044": 0.5584990978240967, "1054": 0.12556517124176025, "1057": 0.020300358533859253, "1998": 0.030771657824516296, "2000": 0.022212404757738113, "2003": 0.2622140049934387, "2005": 0.08244366943836212, ... | 2138843 | Diabetes is a group of chronic diseases characterized by hyperglycemia. Modern medical care uses a vast array of lifestyle and pharmaceutical interventions aimed at preventing and controlling hyperglycemia. In addition to ensuring the adequate delivery of glucose to the tissues of the body, treatment of diabetes attemp... | Microvascular and Macrovascular Complications of Diabetes |
{"1011": 0.3923587501049042, "1038": 0.2637155055999756, "1039": 0.5855054259300232, "1050": 0.07884006202220917, "1052": 0.5773153901100159, "1055": 0.9248477816581726, "1997": 0.16524957120418549, "1999": 0.11168810725212097, "2011": 0.2954642176628113, "2012": 0.1685553640127182, "2029": 0.18978065252304077, "2044":... | 2139357 | BACKGROUND The role of the diffusible messenger nitric oxide (NO) in the regulation of pain transmission is still a debate of matter, pro-nociceptive and/or anti-nociceptive. S-Nitrosylation, the reversible post-translational modification of selective cysteine residues in proteins, has emerged as an important mechanism... | Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide |
{"1040": 0.4932899475097656, "1048": 0.040196798741817474, "1050": 0.1677299439907074, "1051": 0.016465263441205025, "1052": 0.6022219061851501, "1997": 0.07431721687316895, "1999": 0.6931471824645996, "2004": 0.058784693479537964, "2012": 0.500420093536377, "2015": 0.12556517124176025, "2043": 0.05694137513637543, "20... | 2140497 | BACKGROUND Lobular involution, or age-related atrophy of breast lobules, is inversely associated with breast cancer risk, and mammographic breast density (MBD) is positively associated with breast cancer risk. METHODS To evaluate whether lobular involution and MBD are independently associated with breast cancer risk in... | Independent Association of Lobular Involution and Mammographic Breast Density With Breast Cancer Risk |
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