spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1039": 0.1401015669107437, "1044": 0.1994270235300064, "1052": 0.1212492436170578, "1053": 0.13071982562541962, "2002": 0.10291612148284912, "2003": 0.18004031479358673, "2011": 0.14349138736724854, "2029": 0.1873544454574585, "2037": 0.01934296265244484, "2038": 0.022212404757738113, "2044": 0.07341018319129944, "20... | 2701077 | Most adult stem cells, including hematopoietic stem cells (HSCs), are maintained in a quiescent or resting state in vivo. Quiescence is widely considered to be an essential protective mechanism for stem cells that minimizes endogenous stress caused by cellular respiration and DNA replication. We demonstrate that HSC qu... | Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. |
{"1011": 0.5127768516540527, "1017": 0.32199856638908386, "1054": 0.011650617234408855, "1056": 1.1726272106170654, "1996": 0.27564704418182373, "1997": 0.018384648486971855, "1999": 0.0038986403960734606, "2005": 0.037378571927547455, "2007": 0.15943801403045654, "2008": 0.09495500475168228, "2011": 0.1510767638683319... | 2714623 | How membrane receptors initiate signal transduction upon ligand binding is a matter of intense scrutiny. The T cell receptor complex (TCR-CD3) is composed of TCR alpha/beta ligand binding subunits bound to the CD3 subunits responsible for signal transduction. Although it has long been speculated that TCR-CD3 may underg... | Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation |
{"1011": 0.4412745535373688, "1052": 0.10731173306703568, "1178": 1.20182204246521, "1997": 0.2830325961112976, "1999": 0.38041436672210693, "2003": 0.07431721687316895, "2013": 0.18573370575904846, "2015": 0.1358480453491211, "2029": 0.12728634476661682, "2034": 0.2145126610994339, "2063": 0.0038986403960734606, "2064... | 2721426 | RNA molecules contain a variety of chemically diverse, posttranscriptionally modified bases. The most abundant modified base found in cellular RNAs, pseudouridine (Ψ), has recently been mapped to hundreds of sites in mRNAs, many of which are dynamically regulated. Though the pseudouridine landscape has been determined ... | Pseudo-Seq: Genome-Wide Detection of Pseudouridine Modifications in RNA. |
{"1041": 0.006812678650021553, "1996": 0.3982778787612915, "1997": 0.056018441915512085, "2002": 0.19782574474811554, "2003": 0.10555581003427505, "2010": 0.9493325352668762, "2014": 0.6420594453811646, "2049": 0.19622190296649933, "2054": 0.24325250089168549, "2079": 0.10467668622732162, "2081": 0.036437395960092545, ... | 2722988 | Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of ge... | The Mammalian Epigenome |
{"1006": 0.08154398202896118, "1009": 0.6522845029830933, "1011": 0.20739519596099854, "1015": 0.6165571808815002, "1016": 0.3464667797088623, "1020": 0.21765978634357452, "1041": 0.48008447885513306, "1044": 0.0797421783208847, "1155": 0.4932899475097656, "2003": 0.1602703034877777, "2004": 0.1011524572968483, "2007":... | 2727303 | Stromal-interaction molecule 1 (STIM1) is an endoplasmic reticulum Ca(2+) storage sensor that promotes cell growth, migration, and angiogenesis in breast and cervical cancers. Here, we report that the microtubule-associated histone deacetylase 6 (HDAC6) differentially regulates activation of STIM1-mediated store-operat... | Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors. |
{"1011": 0.07068414986133575, "1020": 0.0842406153678894, "1050": 0.7426811456680298, "1056": 0.8877626657485962, "1164": 0.22157983481884003, "2005": 0.129004567861557, "2011": 0.2607102394104004, "2015": 0.1930064558982849, "2029": 0.25239890813827515, "2063": 0.41840189695358276, "2076": 0.3850763738155365, "2079": ... | 2734421 | Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens. However, signals underlying mTEC development remain largely unclear. Here, we demonstrate crucial regulation of mTEC development by receptor activ... | The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. |
{"1011": 0.055094651877880096, "1043": 0.3409265875816345, "1059": 0.04394211992621422, "1997": 0.1994270235300064, "2025": 0.018384648486971855, "2029": 0.08782484382390976, "2038": 0.23247487843036652, "2042": 0.026976587250828743, "2045": 0.04207121208310127, "2050": 0.5557019114494324, "2057": 0.02887592278420925, ... | 2739854 | Genome-wide association studies have greatly improved our understanding of the genetic basis of disease risk. The fact that they tend not to identify more than a fraction of the specific causal loci has led to divergence of opinion over whether most of the variance is hidden as numerous rare variants of large effect or... | Rare and common variants: twenty arguments |
{"1011": 0.11691460013389587, "1043": 0.8691008687019348, "1999": 0.07068414986133575, "2003": 0.04207121208310127, "2007": 0.009718249551951885, "2008": 0.025073638185858727, "2011": 0.4132472574710846, "2012": 0.1889725625514984, "2029": 0.12642613053321838, "2064": 0.28082266449928284, "2073": 0.01934296265244484, "... | 2754534 | Cell-selective glucocorticoid receptor (GR) binding to distal regulatory elements is associated with cell type-specific regions of locally accessible chromatin. These regions can either pre-exist in chromatin (pre-programmed) or be induced by the receptor (de novo). Mechanisms that create and maintain these sites are n... | DNA methylation status predicts cell type-specific enhancer activity. |
{"1011": 0.151916041970253, "1018": 0.2983669638633728, "1038": 0.987156867980957, "1043": 0.9900637865066528, "1999": 0.08064348995685577, "2002": 0.9394577741622925, "2006": 0.021256839856505394, "2007": 0.1751343309879303, "2008": 0.07793712615966797, "2011": 0.35403475165367126, "2029": 0.37102460861206055, "2057":... | 2758012 | Based on its in vitro unwinding activity on G-quadruplex (G4) DNA, the Bloom syndrome-associated helicase BLM is proposed to participate in telomere replication by aiding fork progression through G-rich telomeric DNA. Single molecule analysis of replicated DNA (SMARD) was used to determine the contribution of BLM helic... | BLM helicase facilitates telomere replication during leading strand synthesis of telomeres |
{"1039": 0.052318159490823746, "1997": 0.04394211992621422, "2001": 0.3269403576850891, "2006": 0.8212929964065552, "2008": 0.06429435312747955, "2010": 0.3409265875816345, "2011": 0.07068414986133575, "2026": 1.4441578388214111, "2029": 0.41195443272590637, "2033": 0.18573370575904846, "2034": 0.33953672647476196, "20... | 2762601 | Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified. Since that time, MYC research has been intense and the advances impressive. On reflection, it is astonishing how each incremental insight into MYC regulation and function has also had an impact on numerous biological disciplines,... | Reflecting on 25 years with MYC |
{"1011": 0.15526613593101501, "1017": 0.4974553883075714, "1043": 0.30558720231056213, "1044": 0.319873183965683, "1052": 0.7500885725021362, "2005": 0.11168810725212097, "2011": 0.255429208278656, "2029": 0.11951763927936554, "2048": 0.05786345899105072, "2058": 0.503966212272644, "2064": 0.11865071207284927, "2071": ... | 2774906 | Physical activity protects against cardiovascular disease, and physiological cardiac hypertrophy associated with regular exercise is usually beneficial, in marked contrast to pathological hypertrophy associated with disease. The p110alpha isoform of phosphoinositide 3-kinase (PI3K) plays a critical role in the inductio... | Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. |
{"1014": 0.4556184411048889, "1051": 0.6286086440086365, "1052": 0.24401791393756866, "1156": 0.4752389192581177, "1998": 0.04674193635582924, "2020": 0.004870930220931768, "2060": 0.010684899985790253, "2076": 0.23092569410800934, "2090": 0.1693800985813141, "2106": 0.0913962796330452, "2107": 0.129004567861557, "2119... | 2787558 | BACKGROUND Lifestyle factors including cigarette smoking, alcohol consumption and nutritional habits impact on health, wellness, and the risk of chronic diseases. In the areas of in-vitro fertilization (IVF) and pregnancy, lifestyle factors influence oocyte production, fertilization rates, pregnancy and pregnancy loss,... | The effect of cigarette smoking, alcohol consumption and fruit and vegetable consumption on IVF outcomes: a review and presentation of original data |
{"1011": 0.2026219218969345, "1023": 0.7009293437004089, "2000": 0.14349138736724854, "2003": 0.08064348995685577, "2005": 0.3615458607673645, "2007": 0.2711893916130066, "2011": 0.18492233753204346, "2015": 0.30558720231056213, "2029": 0.1332872211933136, "2035": 0.04860413447022438, "2045": 0.011650617234408855, "204... | 2810997 | The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 system has been widely used for nuclear DNA editing to generate mutations or correct specific disease alleles. Despite its flexible application, it has not been determined if CRISPR/Cas9, originally identified as a bacterial defense system agai... | Efficient Mitochondrial Genome Editing by CRISPR/Cas9 |
{"1011": 0.1384023278951645, "1012": 0.03266380727291107, "1015": 0.010684899985790253, "1019": 0.11778303235769272, "1038": 0.7115318179130554, "1044": 0.8074519634246826, "1050": 0.9409833550453186, "1055": 0.23556606471538544, "1062": 1.202995777130127, "1996": 0.3141832649707794, "1997": 0.14095009863376617, "1999"... | 2817000 | In S. cerevisiae, histone variant H2A.Z is deposited in euchromatin at the flanks of silent heterochromatin to prevent its ectopic spread. We show that H2A.Z nucleosomes are found at promoter regions of nearly all genes in euchromatin. They generally occur as two positioned nucleosomes that flank a nucleosome-free regi... | Histone Variant H2A.Z Marks the 5′ Ends of Both Active and Inactive Genes in Euchromatin |
{"1009": 0.2478361576795578, "1020": 0.5174443125724792, "1044": 0.8374842405319214, "1050": 0.0058422754518687725, "1052": 0.6441128253936768, "1053": 0.1358480453491211, "1998": 0.18573370575904846, "2001": 0.06795065850019455, "2007": 0.0606246218085289, "2034": 0.2539152204990387, "2040": 0.6583697199821472, "2044"... | 2820454 | BACKGROUND Pulmonary hypertension (PH) is associated with restricted physical capacity, limited quality of life, and a poor prognosis because of right heart failure. The present study is the first prospective randomized study to evaluate the effects of exercise and respiratory training in patients with severe symptomat... | Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. |
{"1009": 0.5651806592941284, "1011": 0.26820653676986694, "1015": 0.7638313174247742, "1018": 0.32341301441192627, "1039": 0.10993985831737518, "1044": 0.15693697333335876, "1045": 0.22392450273036957, "1056": 0.7701805830001831, "1998": 0.04767346754670143, "1999": 0.01934296265244484, "2000": 0.12556517124176025, "20... | 2824347 | The introduction in 1996 of the HAART raised hopes for the eradication of HIV-1. Unfortunately, the discovery of latent HIV-1 reservoirs in CD4+ T cells and in the monocyte-macrophage lineage proved the optimism to be premature. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. In... | HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes. |
{"1038": 0.7683706283569336, "1041": 0.6512666940689087, "1052": 0.07341018319129944, "2005": 0.14686977863311768, "2044": 0.5562619566917419, "2062": 0.05694137513637543, "2064": 0.4512746334075928, "2079": 0.0606246218085289, "2094": 0.6548244953155518, "2099": 0.06886265426874161, "2102": 0.4679262638092041, "2106":... | 2825340 | [Purpose] The present study examined whether electro-acupuncture therapy reduces post-stroke depression (PSD) and whether motor function impairments interact with the effects of the therapy. [Subjects] Twenty-eight PSD patients were assessed and assigned to either a good or poor motor function group depending on their ... | Effects of Electro-Acupuncture Therapy on Post-Stroke Depression in Patients with Different Degrees of Motor Function Impairments: a Pilot Study |
{"1011": 0.3443928062915802, "1041": 0.5381823778152466, "1043": 0.6228629946708679, "1054": 0.10555581003427505, "1056": 0.9317949414253235, "1062": 0.32129061222076416, "2007": 0.13670019805431366, "2029": 0.2800849378108978, "2044": 0.12038381397724152, "2064": 0.13071982562541962, "2075": 0.18411032855510712, "2076... | 2825380 | Tcell antigen receptor (TCR) ligation initiates tyrosine kinase activation, signaling complex assembly, and immune synapse formation. Here, we studied the kinetics and mechanics of signaling complex formation in live Jurkat leukemic T cells using signaling proteins fluorescently tagged with variants of enhanced GFP (EG... | T cell receptor ligation induces the formation of dynamically regulated signaling assemblies |
{"1011": 0.08513788133859634, "1042": 0.1229778528213501, "2006": 0.053244512528181076, "2011": 0.38308101892471313, "2013": 0.3883931338787079, "2029": 0.09228714555501938, "2033": 0.6317287683486938, "2037": 0.12814582884311676, "2044": 0.4574742913246155, "2057": 0.03925827145576477, "2058": 0.5827828645706177, "207... | 2828460 | RATIONALE Fibrosis is mediated partly by extracellular matrix-depositing fibroblasts in the heart. Although these mesenchymal cells are reported to have multiple embryonic origins, the functional consequence of this heterogeneity is unknown. OBJECTIVE We sought to validate a panel of surface markers to prospectively id... | Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation. |
{"1003": 0.03831886500120163, "1011": 0.18004031479358673, "1041": 0.24248650670051575, "1043": 0.3777405619621277, "1044": 0.20102575421333313, "1052": 0.31845372915267944, "1998": 0.2652147710323334, "2003": 0.2918238639831543, "2013": 0.09228714555501938, "2015": 0.11081436276435852, "2029": 0.15860503911972046, "20... | 2829179 | Pre-eclampsia is a hypertensive disease of pregnancy with a worldwide incidence of 5-8%. This review focuses on recent developments in pre-eclampsia research related to angiogenesis and metabolism. We first address the 'angiogenic imbalance' theory, which hypothesizes that pre-eclampsia results from an imbalance of fac... | Pre-eclampsia: connecting angiogenic and metabolic pathways. |
{"1011": 0.00875066313892603, "1041": 0.41065993905067444, "1047": 0.8925741910934448, "1048": 1.0492360591888428, "2003": 0.3297532796859741, "2010": 0.854249119758606, "2029": 0.18167030811309814, "2044": 0.10467668622732162, "2061": 0.11343330889940262, "2100": 0.27712854743003845, "2139": 0.09761575609445572, "2140... | 2831620 | Lysine acetylation is a reversible posttranslational modifcation, an epigenetic phenomenon, referred to as transfer of an acetyl group from acetyl CoA to lysine e- amino group of targeted protein, which is modulated by acetyltransferases (histone/ lysine (K) acetyltransferases, HATs/KATs) and deacetylases (histone/lysi... | Protein Lysine Acetylated/Deacetylated Enzymes and the Metabolism-Related Diseases |
{"1011": 0.18248429894447327, "1018": 0.06795065850019455, "1042": 0.8658194541931152, "1043": 0.30486753582954407, "1047": 1.147526502609253, "1998": 0.14264501631259918, "1999": 0.11865071207284927, "2007": 0.5838727951049805, "2008": 0.4537591338157654, "2011": 0.2881702482700348, "2012": 0.4462870955467224, "2029":... | 2832403 | BACKGROUND Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity and diabetes. However, the identity of the predominant metabolic tissue in which a major FGFR-KLB resides that critically mediates the different... | Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB |
{"1011": 0.13925230503082275, "1018": 0.23479416966438293, "1019": 0.053244512528181076, "1038": 0.6107416749000549, "1039": 0.2394166737794876, "1041": 0.7047978043556213, "1044": 0.7239188551902771, "1045": 0.42990362644195557, "1052": 0.8442239761352539, "1056": 0.07250232994556427, "2002": 0.8925741910934448, "2003... | 2837758 | Epitope vaccine is a promising option for therapeutic vaccination against Helicobacter pylori (H. pylori) infection. In this study, we constructed a multi-epitope vaccine with five epitopes and mucosal adjuvant E. coli heat-labile enterotoxin B subunit (LTB) named HUepi-LTB and evaluated its therapeutic effect against ... | Therapeutic efficacy of a multi-epitope vaccine against Helicobacter pylori infection in BALB/c mice model. |
{"1056": 0.3325583338737488, "1997": 0.16690383851528168, "1998": 0.12038381397724152, "1999": 0.3615458607673645, "2007": 0.14349138736724854, "2011": 0.12986256182193756, "2013": 0.7191727757453918, "2029": 0.0752234235405922, "2042": 0.20421554148197174, "2044": 0.17840765416622162, "2050": 0.23710809648036957, "206... | 2841164 | Increased levels of DNA fragments have frequently been found in the blood plasma of cancer patients. Published data suggest that only a fraction of the DNA in blood plasma is derived from cancer cells. However, it is not known how much of the circulating DNA is from cancer or from noncancer cells. By quantitative methy... | DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. |
{"1011": 0.015504186972975731, "1014": 0.03925827145576477, "1016": 0.40220460295677185, "1017": 0.2231435477733612, "1040": 0.45994341373443604, "1043": 0.5528968572616577, "1048": 0.43938836455345154, "1050": 0.04394211992621422, "1051": 0.36697331070899963, "1998": 0.09228714555501938, "1999": 0.3656192123889923, "2... | 2842550 | BACKGROUND Platelet deposition and aggregation are central to the pathogenesis of ischemic complications of acute coronary syndromes (ACS). Pharmacodynamic effects of the platelet glycoprotein IIb/IIIa antagonist eptifibatide have been delineated in healthy subjects but not in patients with ACS. We assessed effects of ... | Pharmacodynamics and pharmacokinetics of eptifibatide in patients with acute coronary syndromes: prospective analysis from PURSUIT. |
{"1011": 0.3883931338787079, "1015": 0.35334911942481995, "1039": 0.07793712615966797, "1055": 0.3956514894962311, "1056": 0.7333439588546753, "1157": 0.13243216276168823, "1998": 0.012615402229130268, "1999": 0.016465263441205025, "2002": 0.1064341589808464, "2005": 0.2674594223499298, "2008": 0.02412080205976963, "20... | 2844490 | PURPOSE OF REVIEW To encapsulate our current understanding of the proinflammatory cytokines responsible for the inflammation underlying Crohn's disease and the prospect of using this information to devise therapy for this condition based on inhibition of these cytokines. RECENT FINDINGS Current research is shedding new... | Proinflammatory cytokines underlying the inflammation of Crohn's disease. |
{"1037": 0.058784693479537964, "2000": 0.052318159490823746, "2003": 0.11517547070980072, "2007": 0.015504186972975731, "2028": 0.09495500475168228, "2047": 0.5045560002326965, "2054": 0.1930064558982849, "2099": 0.0354953333735466, "2109": 0.5301685929298401, "2129": 0.18248429894447327, "2135": 0.07612881064414978, "... | 2844897 | In clinical measurement comparison of a new measurement technique with an established one is often needed to see whether they agree sufficiently for the new to replace the old. Such investigations are often analysed inappropriately, notably by using correlation coefficients. The use of correlation is misleading. An alt... | STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT |
{"1011": 0.14686977863311768, "1038": 0.9857001900672913, "1043": 0.40806588530540466, "1061": 0.8315495252609253, "2004": 0.11343330889940262, "2005": 0.03925827145576477, "2008": 0.026976587250828743, "2011": 0.3464667797088623, "2012": 0.4437839686870575, "2029": 0.22157983481884003, "2034": 0.3318578004837036, "206... | 2851611 | Expression of particular drug transporters in response to antibiotic pressure is a critical element in the development of bacterial multidrug resistance, and represents a serious concern for human health. To obtain a better understanding of underlying regulatory mechanisms, we have dissected the transcriptional activat... | The multidrug ABC transporter BmrC/BmrD of Bacillus subtilis is regulated via a ribosome-mediated transcriptional attenuation mechanism |
{"1009": 0.6679295301437378, "1011": 0.15526613593101501, "1039": 0.30989447236061096, "1043": 0.6022219061851501, "1996": 0.12986256182193756, "1998": 0.20660123229026794, "2007": 0.25239890813827515, "2008": 0.007782140281051397, "2011": 0.21135559678077698, "2015": 0.8004589080810547, "2024": 0.0317181795835495, "20... | 2853291 | Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic stem cell (HSC) niche in the bone marrow of long bones. However, their developmental relationships remain unclear. In this study, we demonstrate that different MSC populations in the developing marrow of long bones have distinct functi... | The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function |
{"1011": 0.2394166737794876, "1039": 0.8941729068756104, "2005": 0.15777134895324707, "2008": 0.11517547070980072, "2010": 0.8117979168891907, "2012": 0.010684899985790253, "2015": 0.5696102976799011, "2029": 0.2689530849456787, "2034": 0.19622190296649933, "2044": 0.23247487843036652, "2046": 0.4002431631088257, "2061... | 2853685 | Induced pluripotent stem cells (iPSCs) offer immense potential for regenerative medicine and studies of disease and development. Somatic cell reprogramming involves epigenomic reconfiguration, conferring iPSCs with characteristics similar to embryonic stem (ES) cells. However, it remains unknown how complete the reesta... | Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells |
{"1014": 0.21214580535888672, "1038": 0.49626702070236206, "1042": 0.7067264318466187, "1045": 0.3601844012737274, "1052": 0.2881702482700348, "1054": 0.417115718126297, "1060": 0.11517547070980072, "1061": 1.15000319480896, "1999": 0.2034190446138382, "2004": 0.0038986403960734606, "2007": 0.1358480453491211, "2012": ... | 2867345 | BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this sexual inequity. METHODS We genotyped 11 markers of the male-specific re... | Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome |
{"1012": 0.19622190296649933, "1016": 0.23710809648036957, "1022": 0.5517725944519043, "1046": 0.10906458646059036, "1048": 0.6160298585891724, "2003": 0.5197699069976807, "2006": 0.06154331564903259, "2007": 0.014542185701429844, "2047": 0.0354953333735466, "2064": 0.20580662786960602, "2109": 0.3560888469219208, "212... | 2883827 | UNLABELLED Cytoscape is a popular bioinformatics package for biological network visualization and data integration. Version 2.8 introduces two powerful new features--Custom Node Graphics and Attribute Equations--which can be used jointly to greatly enhance Cytoscape's data integration and visualization capabilities. Cu... | Cytoscape 2.8: new features for data integration and network visualization |
{"1011": 0.07612881064414978, "1044": 0.09406650811433792, "1048": 0.3910386264324188, "1055": 0.04207121208310127, "2002": 0.35334911942481995, "2005": 0.04207121208310127, "2007": 0.15610189735889435, "2010": 1.19888174533844, "2012": 0.39367714524269104, "2025": 0.11430477350950241, "2026": 0.42990362644195557, "202... | 2888272 | Chromatin immunoprecipitation assays have contributed greatly to our understanding of the role of histone modifications in gene regulation. However, they do not permit analysis with single-cell resolution, thus confounding analyses of heterogeneous cell populations. Here we present a method that permits visualization o... | Detection of Histone Modifications at Specific Gene Loci in Single Cells in Histological Sections |
{"1011": 0.3077431619167328, "1016": 0.2184450328350067, "1019": 0.22626367211341858, "1039": 0.3005385100841522, "1041": 0.4158279001712799, "1050": 0.6517757177352905, "1055": 0.3374483287334442, "1057": 0.841701865196228, "1061": 0.6441128253936768, "1997": 0.18573370575904846, "1999": 0.13414156436920166, "2005": 0... | 2890952 | The wobble modification in tRNAs, 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U), is required for the proper decoding of NNR codons in eukaryotes. The 2-thio group confers conformational rigidity of mcm(5)s(2)U by largely fixing the C3'-endo ribose puckering, ensuring stable and accurate codon-anticodon pairing. W... | Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions |
{"1044": 0.3177432417869568, "1998": 0.11517547070980072, "2012": 0.17020416259765625, "2015": 0.13670019805431366, "2018": 0.05970508232712746, "2031": 0.12814582884311676, "2048": 0.01934296265244484, "2053": 0.052318159490823746, "2062": 0.04207121208310127, "2064": 0.0019512200960889459, "2066": 0.4067663550376892,... | 2891825 | OBJECTIVES To study the prevalence of asthma (asthma symptoms and bronchial hyperresponsiveness) in Swedish cross country skiers compared with non-skiers and monitor changes in symptoms and bronchial hyperresponsiveness during the year. DESIGN Cross sectional study during the winter ski season and in the summer. SETTIN... | High prevalence of asthma in cross country skiers. |
{"1005": 0.14349138736724854, "1011": 0.34922540187835693, "1017": 0.09850110858678818, "1019": 0.36967599391937256, "1041": 0.18978065252304077, "1053": 0.39893341064453125, "1054": 0.40351006388664246, "2002": 0.8264343738555908, "2004": 0.043007105588912964, "2005": 0.22704219818115234, "2006": 0.08692999184131622, ... | 2904102 | RecQ family helicases function as safeguards of the genome. Unlike Escherichia coli, the Gram-positive Bacillus subtilis bacterium possesses two RecQ-like homologues, RecQ[Bs] and RecS, which are required for the repair of DNA double-strand breaks. RecQ[Bs] also binds to the forked DNA to ensure a smooth progression of... | Characterization of biochemical properties of Bacillus subtilis RecQ helicase. |
{"1011": 0.12728634476661682, "1013": 0.4487839937210083, "1015": 0.7601850032806396, "1040": 0.015504186972975731, "1043": 0.3163207769393921, "1051": 0.42353010177612305, "1055": 0.3304552733898163, "1061": 0.678390383720398, "1062": 1.1369311809539795, "1999": 0.022212404757738113, "2003": 0.22626367211341858, "2005... | 2919030 | Cu/Zn superoxide dismutase (SOD1) is an abundant enzyme that has been best studied as a regulator of antioxidant defense. Using the yeast Saccharomyces cerevisiae, we report that SOD1 transmits signals from oxygen and glucose to repress respiration. The mechanism involves SOD1-mediated stabilization of two casein kinas... | SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration |
{"1013": 0.22626367211341858, "1014": 0.38174858689308167, "1017": 0.18004031479358673, "1022": 0.06246116757392883, "1026": 0.07250232994556427, "1040": 0.7537717819213867, "1048": 0.46302130818367004, "1052": 0.8829278349876404, "1059": 0.10555581003427505, "1998": 0.03360854089260101, "2004": 0.12038381397724152, "2... | 2931832 | Activated platelets promote tumor cell growth, angiogenesis, and invasion. Platelet activity can be inferred by platelet volume indices (PVIs), which include platelet distribution width (PDW), mean platelet volume (MPV), platelet distribution width-to-platelet count ratio (PDW/P), and mean platelet volume-to-platelet c... | The prognostic impact of the platelet distribution width-to-platelet count ratio in patients with breast cancer |
{"1011": 0.38574060797691345, "1015": 0.39762192964553833, "1045": 0.981317400932312, "1048": 0.5696102976799011, "1056": 0.07159364968538284, "2028": 0.1685553640127182, "2029": 0.24325250089168549, "2044": 0.33115679025650024, "2065": 1.229617714881897, "2072": 0.23864774405956268, "2075": 0.401551216840744, "2076": ... | 2947124 | During persistent viral infections, chronic immune activation, negative immune regulator expression, an elevated interferon signature, and lymphoid tissue destruction correlate with disease progression. We demonstrated that blockade of type I interferon (IFN-I) signaling using an IFN-I receptor neutralizing antibody re... | Persistent LCMV infection is controlled by blockade of type I interferon signaling. |
{"1020": 0.6011518239974976, "1050": 0.6223390698432922, "1058": 0.09584271162748337, "1996": 0.1718502640724182, "1999": 0.20977331697940826, "2005": 0.08871890604496002, "2015": 0.06703783571720123, "2046": 0.06886265426874161, "2048": 0.47402387857437134, "2064": 0.09938567131757736, "2073": 0.3170322775840759, "207... | 2947540 | Communication between organelles is crucial for eukaryotic cells to function as one coherent unit. An important means of communication is through membrane contact sites, where two organelles come into close proximity allowing the transport of lipids and small solutes between them. Contact sites are dynamic in size and ... | Lam6 Regulates the Extent of Contacts between Organelles |
{"1043": 0.2231435477733612, "1045": 0.46117570996284485, "1996": 0.5773153901100159, "1997": 0.03925827145576477, "1998": 0.17759032547473907, "2011": 0.23247487843036652, "2049": 0.1913948506116867, "2054": 0.1358480453491211, "2076": 0.27044451236724854, "2079": 0.4734157919883728, "2080": 0.05970508232712746, "2083... | 2958458 | The environment in which the fetus develops is critical for its survival and long-term health. The regulation of normal human fetal growth involves many multidirectional interactions between the mother, placenta, and fetus. The mother supplies nutrients and oxygen to the fetus via the placenta. The fetus influences the... | Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus. |
{"1011": 0.319873183965683, "1021": 0.6813592314720154, "1038": 0.4349733293056488, "1042": 0.1358480453491211, "1054": 0.6249561905860901, "1056": 0.4002431631088257, "1156": 0.3777405619621277, "2003": 0.15023678541183472, "2011": 0.2470736801624298, "2013": 0.27342069149017334, "2026": 0.5209306478500366, "2033": 0.... | 2973910 | Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption of normal myocardial structures, results from excessive deposition of extracellular matrix, which is mediated by the recruitment of fibroblasts. The source of these fibroblasts is unclear and specific anti-fibrotic therapies ar... | Endothelial-to-mesenchymal transition contributes to cardiac fibrosis |
{"1017": 0.3777405619621277, "1054": 0.7898768186569214, "1057": 0.7881022095680237, "1996": 0.16359257698059082, "1998": 0.20660123229026794, "2005": 0.13670019805431366, "2011": 0.11256109178066254, "2013": 0.15943801403045654, "2029": 0.15359249711036682, "2050": 0.6054253578186035, "2061": 0.8212929964065552, "2069... | 2988714 | Local translation mediates axonal responses to Semaphorin3A (Sema3A) and other guidance cues. However, only a subset of the axonal proteome is locally synthesized, whereas most proteins are trafficked from the soma. The reason why only specific proteins are locally synthesized is unknown. Here we show that local protei... | Coupled local translation and degradation regulate growth cone collapse |
{"1011": 0.259204238653183, "1043": 0.02792670577764511, "1047": 0.14179791510105133, "1056": 0.7380234599113464, "1060": 0.7124901413917542, "1999": 0.02316705882549286, "2005": 0.19782574474811554, "2006": 0.06977381557226181, "2008": 0.007782140281051397, "2015": 0.7028654217720032, "2029": 0.32270604372024536, "207... | 2991954 | Production of Ran-guanosine triphosphate (GTP) around chromosomes induces local nucleation and plus end stabilization of microtubules (MTs). The nuclear protein TPX2 is required for RanGTP-dependent MT nucleation. To find the MT stabilizer, we affinity purify nuclear localization signal (NLS)-containing proteins from X... | Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate |
{"1055": 0.22782009840011597, "1999": 0.09672962874174118, "2011": 0.1970241367816925, "2015": 0.3423145115375519, "2028": 0.004870930220931768, "2037": 0.42096930742263794, "2047": 0.1011524572968483, "2049": 0.13499516248703003, "2059": 0.2034190446138382, "2062": 0.12728634476661682, "2064": 0.4151833653450012, "206... | 3001685 | Building a mathematical model of population dynamics of pathogens within their host involves considerations of factors similar to those in ecology, as pathogens can prey on cells in the host. But within the multicellular host, attacked cell types are integrated with other cellular systems, which in turn intervene in th... | Population dynamics of a pathogen: the conundrum of vivax malaria |
{"1052": 1.2824517488479614, "1997": 0.17840765416622162, "1998": 0.3757305145263672, "2002": 0.6096806526184082, "2007": 0.0174254160374403, "2011": 0.14602625370025635, "2015": 0.3923587501049042, "2024": 0.23402166366577148, "2029": 0.34922540187835693, "2031": 0.1384023278951645, "2038": 0.04674193635582924, "2048"... | 3033830 | RNases P and MRP are ribonucleoprotein complexes involved in tRNA and rRNA processing, respectively. The RNA subunits of these two enzymes are structurally related to each other and play an essential role in the enzymatic reaction. Both of the RNAs have a highly conserved helical region, P4, which is important in the c... | Identification and analysis of ribonuclease P and MRP RNA in a broad range of eukaryotes |
{"1009": 0.09672962874174118, "1013": 0.1905880719423294, "1014": 0.08961215615272522, "1016": 0.16110190749168396, "1040": 0.9827804565429688, "1048": 0.10906458646059036, "1999": 0.09584271162748337, "2012": 0.37707099318504333, "2025": 0.02316705882549286, "2048": 0.5968599319458008, "2051": 0.02792670577764511, "20... | 3034412 | BACKGROUND Calcium absorption is generally considered to be impaired under conditions of vitamin D deficiency, but the vitamin D status that fully normalizes absorption is not known for humans. OBJECTIVE To quantify calcium absorption at two levels of vitamin D repletion, using pharmacokinetic methods and commercially ... | Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. |
{"1051": 0.0009760859538801014, "1058": 0.1751343309879303, "2015": 0.14095009863376617, "2025": 0.1946154683828354, "2079": 0.24018502235412598, "2090": 0.35745587944984436, "2129": 0.11778303235769272, "2138": 0.48068851232528687, "2182": 0.08692999184131622, "2236": 0.5822374224662781, "2306": 0.27342069149017334, "... | 3038933 | Standard virulence evolution theory assumes that virulence factors are maintained because they aid parasitic exploitation, increasing growth within and/or transmission between hosts. An increasing number of studies now demonstrate that many opportunistic pathogens (OPs) do not conform to these assumptions, with virulen... | Evolution of virulence in opportunistic pathogens: generalism, plasticity, and control |
{"1011": 0.18654440343379974, "1015": 0.1064341589808464, "1016": 0.1946154683828354, "1017": 0.2145126610994339, "1039": 0.43875885009765625, "1041": 0.7191727757453918, "1044": 0.5045560002326965, "1047": 0.004870930220931768, "1048": 0.09495500475168228, "1052": 0.17020416259765625, "1999": 0.0038986403960734606, "2... | 3052213 | The growing epidemic of obesity and metabolic diseases calls for a better understanding of adipocyte biology. The regulation of transcription in adipocytes is particularly important, as it is a target for several therapeutic approaches. Transcriptional outcomes are influenced by both histone modifications and transcrip... | Genome-Wide Profiling of H3K56 Acetylation and Transcription Factor Binding Sites in Human Adipocytes |
{"1054": 0.33675122261047363, "1999": 0.08782484382390976, "2001": 0.1808556467294693, "2005": 0.07341018319129944, "2008": 0.02887592278420925, "2015": 0.48068851232528687, "2020": 0.18329764902591705, "2024": 0.06977381557226181, "2029": 0.35813871026039124, "2034": 0.4728073179721832, "2038": 0.12728634476661682, "2... | 3052642 | Circular RNA transcripts were first identified in the early 1990s but knowledge of these species has remained limited, as their study through traditional methods of RNA analysis has been difficult. Now, novel bioinformatic approaches coupled with biochemical enrichment strategies and deep sequencing have allowed compre... | Detecting and characterizing circular RNAs |
{"1011": 0.17267228662967682, "1016": 0.04113444685935974, "1017": 0.46363574266433716, "1043": 0.3864043951034546, "1056": 0.9131608605384827, "1999": 0.007782140281051397, "2001": 0.016465263441205025, "2002": 0.7881022095680237, "2003": 0.39433568716049194, "2004": 0.13071982562541962, "2010": 0.6435998678207397, "2... | 3056682 | Unstable angina is a critical phase of coronary heart disease with widely variable symptoms and prognosis. A decade ago, a classification of unstable angina based on clinical symptoms was introduced. This system was then validated by prospective clinical studies to correlate with the prognosis and was linked to angiogr... | A classification of unstable angina revisited. |
{"1014": 0.30558720231056213, "1020": 0.07884006202220917, "1044": 0.7258110046386719, "1050": 0.09850110858678818, "1052": 0.4818955361843109, "2005": 0.05046287178993225, "2007": 0.17020416259765625, "2029": 0.1619328260421753, "2038": 0.026025565341114998, "2042": 0.10993985831737518, "2084": 0.4093637466430664, "20... | 3067015 | BACKGROUND Alcohol has been reported to be a common and modifiable risk factor for hypertension. However, observational studies are subject to confounding by other behavioural and sociodemographic factors, while clinical trials are difficult to implement and have limited follow-up time. Mendelian randomization can prov... | Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach |
{"1011": 0.19381128251552582, "1019": 0.35745587944984436, "1039": 1.0080435276031494, "1046": 0.4002431631088257, "1053": 0.2719337046146393, "2000": 0.083342544734478, "2004": 0.22392450273036957, "2005": 0.15275461971759796, "2043": 0.08064348995685577, "2051": 0.5941681861877441, "2062": 0.14602625370025635, "2064"... | 3078080 | UNLABELLED Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing specimens are valuable in distinguishing CJD from non-CJD conditions but h... | Rapid and Sensitive RT-QuIC Detection of Human Creutzfeldt-Jakob Disease Using Cerebrospinal Fluid |
{"1011": 0.1384023278951645, "1017": 0.5495203733444214, "1019": 0.2659635543823242, "1021": 0.1212492436170578, "1039": 0.21922965347766876, "1042": 0.5086748600006104, "1044": 0.16442140936851501, "1048": 0.4950772523880005, "1051": 0.45994341373443604, "1052": 0.055094651877880096, "1999": 0.05046287178993225, "2000... | 3078550 | BACKGROUND Generalized resistance of some neoplastic cell lines to treatment with ligand-toxin chimeras has been attributed to an increased rate of lysosomal uptake and degradation following endocytosis of the chimera-receptor complex. Because phosphoinositide 3-kinase (Pl 3-kinase) activity is known to play a role in ... | Wortmannin, a phosphoinositide 3-kinase inhibitor, selectively enhances cytotoxicity of receptor-directed-toxin chimeras in vitro and in vivo. |
{"1015": 0.043007105588912964, "1019": 0.058784693479537964, "1020": 0.36697331070899963, "1038": 0.6674286723136902, "1040": 0.2394166737794876, "1043": 1.0788878202438354, "1155": 0.5562619566917419, "1998": 0.021256839856505394, "2007": 0.06520967930555344, "2012": 0.11081436276435852, "2020": 0.10467668622732162, "... | 3083927 | We propose a model wherein chronic stress results in glucocorticoid receptor resistance (GCR) that, in turn, results in failure to down-regulate inflammatory response. Here we test the model in two viral-challenge studies. In study 1, we assessed stressful life events, GCR, and control variables including baseline anti... | Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. |
{"1009": 0.512191891670227, "1011": 0.21214580535888672, "1015": 0.5947071313858032, "1017": 0.38174858689308167, "1020": 0.42416930198669434, "1039": 0.46608972549438477, "1043": 0.9162907600402832, "1044": 0.44753631949424744, "1052": 0.8074519634246826, "1996": 0.04860413447022438, "2006": 0.0606246218085289, "2008"... | 3085264 | In the brain, glutamatergic neurotransmission is terminated predominantly by the rapid uptake of synaptically released glutamate into astrocytes through the Na(+)-dependent glutamate transporters GLT-1 and GLAST and its subsequent conversion into glutamine by the enzyme glutamine synthetase (GS). To date, several facto... | Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a Neuron-Derived Peptide Regulating Glial Glutamate Transport and Metabolism |
{"1011": 0.12038381397724152, "1014": 0.1358480453491211, "1018": 0.04394211992621422, "1038": 0.9470623731613159, "1043": 0.9131608605384827, "1048": 0.6425731778144836, "1058": 0.15693697333335876, "2001": 0.055094651877880096, "2006": 0.055094651877880096, "2007": 0.029824240133166313, "2011": 0.19541899859905243, "... | 3090454 | In 93 allograft recipients, the numbers of marrow B-cell precursors on days 80 and 365 correlated with the counts of circulating B cells, suggesting that the posttransplantation B-cell deficiency is at least in part due to insufficient B lymphopoiesis. Factors that could affect B lymphopoiesis were evaluated. The numbe... | Factors influencing B lymphopoiesis after allogeneic hematopoietic cell transplantation. |
{"1011": 0.10818854719400406, "1021": 0.129004567861557, "1038": 0.2689530849456787, "1052": 0.5707147121429443, "1053": 0.6989894509315491, "1055": 0.42096930742263794, "1056": 0.2622140049934387, "2003": 0.33675122261047363, "2012": 0.2184450328350067, "2029": 0.2105647772550583, "2050": 0.036437395960092545, "2051":... | 3093512 | AIM Peripheral artery disease (PAD) is a vascular disease affecting peripheral circulation. Recently, genome-wide association studies revealed a relationship between single nucleotide polymorphisms (SNPs) in ADAMTS7 (a disintegrin and metalloprotease with thrombospondin motif 7) and atherosclerosis. In this study, we a... | Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease |
{"1011": 0.12642613053321838, "1020": 0.35060185194015503, "1041": 0.18573370575904846, "1055": 0.34370049834251404, "1996": 0.4041621685028076, "1997": 0.0317181795835495, "1999": 0.0029254043474793434, "2011": 0.07159364968538284, "2013": 0.3409265875816345, "2020": 0.11343330889940262, "2029": 0.17922431230545044, "... | 3095620 | The homologues of the two distinct architectonic areas 44 and 45 that constitute the anterior language zone (Broca's region) in the human ventrolateral frontal lobe were recently established in the macaque monkey. Although we know that the inferior parietal lobule and the lateral temporal cortical region project to the... | Distinct Parietal and Temporal Pathways to the Homologues of Broca's Area in the Monkey |
{"1011": 0.4879087805747986, "1043": 0.006812678650021553, "2000": 0.1718502640724182, "2003": 0.043007105588912964, "2005": 0.11343330889940262, "2007": 0.28597161173820496, "2011": 0.1889725625514984, "2029": 0.1401015669107437, "2033": 0.14939609169960022, "2063": 0.0317181795835495, "2094": 0.08782484382390976, "20... | 3098821 | AIM To develop a reliable method for whole genome analysis of DNA methylation. MATERIALS & METHODS Genome-scale analysis of DNA methylation includes affinity-based approaches such as enrichment using methyl-CpG-binding proteins. One of these methods, the methylated-CpG island recovery assay (MIRA), is based on the high... | MIRA-seq for DNA methylation analysis of CpG islands |
{"1017": 0.09938567131757736, "1018": 0.304147332906723, "1062": 0.17267228662967682, "1997": 0.055094651877880096, "2000": 0.04953393340110779, "2019": 0.05970508232712746, "2022": 0.083342544734478, "2028": 0.44753631949424744, "2048": 0.15693697333335876, "2052": 0.11691460013389587, "2062": 0.4412745535373688, "206... | 3099497 | If an auditory scene consists of many spatially separated sound sources, how many sound sources can be processed by the auditory system? Experiment I determined how many speech sources could be localized simultaneously on the azimuth plane. Different words were played from multiple loudspeakers, and listeners reported ... | How many images are in an auditory scene? |
{"1016": 0.14602625370025635, "1039": 0.29981520771980286, "1054": 0.2160874605178833, "1999": 0.21765978634357452, "2005": 0.12556517124176025, "2011": 0.40351006388664246, "2029": 0.20580662786960602, "2039": 0.3423145115375519, "2076": 0.12556517124176025, "2079": 0.39893341064453125, "2083": 0.0606246218085289, "20... | 3105781 | Copper plays an essential role in processes including signaling to the transcription and protein trafficking machinery, oxidative phosphorylation, iron mobilization, neuropeptide maturation, and normal development. Whereas much is known about intracellular mobilization of ions such as calcium, little information is ava... | Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. |
{"1011": 0.07341018319129944, "1045": 0.21530038118362427, "1049": 0.06337817758321762, "1054": 0.8298473954200745, "1996": 0.2674594223499298, "1999": 0.1401015669107437, "2005": 0.0174254160374403, "2006": 0.1734936386346817, "2007": 0.20421554148197174, "2029": 0.17267228662967682, "2031": 0.043007105588912964, "203... | 3107733 | Peroxisomes have long been established to play a central role in regulating various metabolic activities in mammalian cells. These organelles act in concert with mitochondria to control the metabolism of lipids and reactive oxygen species. However, while mitochondria have emerged as an important site of antiviral signa... | Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity |
{"1014": 0.567397952079773, "1015": 0.11343330889940262, "1017": 0.02887592278420925, "1021": 0.4512746334075928, "1037": 0.016465263441205025, "1041": 0.27934664487838745, "1054": 0.15023678541183472, "2000": 0.3070250153541565, "2028": 0.3526630103588104, "2064": 0.15860503911972046, "2065": 0.006812678650021553, "20... | 3112885 | Simple interval estimate methods for proportions exhibit poor coverage and can produce evidently inappropriate intervals. Criteria appropriate to the evaluation of various proposed methods include: closeness of the achieved coverage probability to its nominal value; whether intervals are located too close to or too dis... | Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat. Med |
{"1018": 0.10291612148284912, "2003": 0.35403475165367126, "2010": 0.8813109993934631, "2011": 0.29109421372413635, "2026": 0.32058215141296387, "2029": 0.09584271162748337, "2033": 0.6280876994132996, "2049": 0.08692999184131622, "2050": 0.4349733293056488, "2091": 0.30486753582954407, "2139": 0.19381128251552582, "21... | 3113630 | Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promotes neurodegeneration. Nuclear HDAC4 binds to chromatin, as well as to myocyte enha... | Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia |
{"1011": 0.40220460295677185, "1017": 0.14179791510105133, "1041": 1.197703242301941, "1047": 0.6921701431274414, "1050": 0.6425731778144836, "1054": 0.49626702070236206, "1056": 0.021256839856505394, "1059": 0.5528968572616577, "1156": 0.4734157919883728, "1159": 0.06520967930555344, "1164": 0.38308101892471313, "1997... | 3118719 | E-cadherin is best characterized as adherens junction protein, which through homotypic interactions contributes to the maintenance of the epithelial barrier function. In epithelial cells, the cytoplasmic tail of E-cadherin forms a dynamic complex with catenins and regulates several intracellular signal transduction pat... | Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs. |
{"1011": 0.5324648022651672, "1015": 1.0144377946853638, "1016": 0.040196798741817474, "1020": 0.1677299439907074, "1021": 0.006812678650021553, "1043": 1.1230508089065552, "1055": 0.46486347913742065, "1996": 0.020300358533859253, "2003": 0.22079704701900482, "2005": 0.10906458646059036, "2008": 0.0019512200960889459,... | 3127341 | The glucagon-like peptide-1 receptor (GLP-1R) is a key physiological regulator of insulin secretion and a major therapeutic target for the treatment of type II diabetes. However, regulation of GLP-1R function is complex with multiple endogenous peptides that interact with the receptor, including full-length (1-37) and ... | Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation. |
{"1009": 0.6280876994132996, "1011": 0.22937409579753876, "1043": 0.5495203733444214, "1047": 0.4938860833644867, "1054": 1.0587663650512695, "1157": 0.5461324453353882, "2011": 0.2822965085506439, "2013": 0.43244171142578125, "2015": 0.3346569836139679, "2029": 0.1011524572968483, "2038": 0.00875066313892603, "2043": ... | 3140772 | Adult neurogenesis arises from neural stem cells within specialized niches. Neuronal activity and experience, presumably acting on this local niche, regulate multiple stages of adult neurogenesis, from neural progenitor proliferation to new neuron maturation, synaptic integration and survival. It is unknown whether loc... | Neuronal circuitry mechanism regulating adult quiescent neural stem cell fate decision |
{"1014": 0.22157983481884003, "1040": 1.160461664199829, "1048": 0.3995884954929352, "1051": 0.04767346754670143, "1052": 0.3963087201118469, "1081": 0.6139179468154907, "2029": 0.06429435312747955, "2084": 0.46117570996284485, "2088": 0.14095009863376617, "2090": 0.23710809648036957, "2140": 0.0029254043474793434, "21... | 3150030 | We performed a meta-analysis of cross-sectional studies on serum 25(OH)D status globally. Serum 25(OH)D levels on average were 54 nmol/l, were higher in women than men, and higher in Caucasians than in non-Caucasians. There was no trend in serum 25(OH)D level with latitude. Vitamin D deficiency was widespread. We studi... | Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis |
{"1011": 0.6244332790374756, "1016": 0.9037119746208191, "1039": 0.14686977863311768, "1040": 0.35745587944984436, "1042": 0.26446542143821716, "1048": 0.4374985992908478, "1997": 0.27712854743003845, "1999": 0.034552380442619324, "2002": 0.7800771594047546, "2011": 0.010684899985790253, "2013": 0.36290550231933594, "2... | 3152612 | A novel differentiation-dependent cDNA (DIF-2) has been isolated from human mononuclear phagocytes by differential display. The full-length cDNA was cloned and sequenced. DIF-2 consists of 156 amino acids and has a predicted isoelectric point of 8.84. The mRNA is expressed in freshly isolated monocytes and is downregul... | Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine. |
{"1011": 0.3374483287334442, "1017": 0.026025565341114998, "1039": 0.7333439588546753, "1040": 0.5882205963134766, "1041": 0.25239890813827515, "1048": 0.603290855884552, "1999": 0.03360854089260101, "2005": 0.04394211992621422, "2008": 0.12038381397724152, "2015": 0.3084607720375061, "2024": 0.04394211992621422, "2029... | 3153673 | Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means to influence health and life span. In C. elegans, bile acid-like steroids called the dafachronic acids (DAs) regulate developmental timing and longevity through the conserved nuclear hormone receptor DAF-12, a homolog of ... | A Novel 3-Hydroxysteroid Dehydrogenase That Regulates Reproductive Development and Longevity |
{"1011": 0.4067663550376892, "1017": 0.5827828645706177, "1050": 0.35403475165367126, "1996": 0.08244366943836212, "1997": 0.07884006202220917, "1998": 0.0913962796330452, "1999": 0.176772341132164, "2005": 0.09672962874174118, "2007": 0.007782140281051397, "2008": 0.011650617234408855, "2011": 0.3416208028793335, "201... | 3154880 | Ribonucleoprotein complexes consisting of Argonaute-like proteins and small regulatory RNAs function in a wide range of biological processes. Many of these small regulatory RNAs are predicted to act, at least in part, within the nucleus. We conducted a genetic screen to identify factors essential for RNA interference (... | An Argonaute transports siRNAs from the cytoplasm to the nucleus. |
{"1011": 0.29473719000816345, "1016": 0.4196864068508148, "1018": 0.3923587501049042, "1019": 0.3877306580543518, "1052": 0.2667117714881897, "1056": 0.38441169261932373, "1996": 0.36697331070899963, "1998": 0.31132611632347107, "2004": 0.025073638185858727, "2007": 0.22001366317272186, "2008": 0.009718249551951885, "2... | 3155374 | Binding interactions between the plasma membrane and the cytoskeleton define cell functions such as cell shape, formation of cell processes, cell movement, and endocytosis. Here we use optical tweezers tether force measurements and show that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP2) acts as a second ... | Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton–Plasma Membrane Adhesion |
{"1011": 0.11865071207284927, "1056": 1.2261852025985718, "1996": 0.016465263441205025, "2005": 0.14686977863311768, "2031": 0.04487626627087593, "2045": 0.2160874605178833, "2046": 0.21135559678077698, "2054": 0.03360854089260101, "2070": 0.30486753582954407, "2079": 0.5069117546081543, "2105": 0.49686139822006226, "2... | 3155731 | T cells have crucial roles in protection against infection and cancer. Although the trafficking of memory T cells around the body is integral to their capacity to provide immune protection, studies have shown that specialization of some memory T cells into unique tissue-resident subsets gives the host enhanced regional... | Tissue-resident memory T cells: local specialists in immune defence |
{"1011": 0.0058422754518687725, "1015": 0.05786345899105072, "1048": 0.056018441915512085, "1056": 0.28963330388069153, "2044": 0.14264501631259918, "2075": 0.21687394380569458, "2076": 0.37640097737312317, "2079": 0.13157635927200317, "2106": 0.24325250089168549, "2128": 0.42353010177612305, "2206": 0.1064341589808464... | 3173489 | DNA replication stress promotes genome instability in cancer. However, the contribution of the replication stress response to the development of malignancies remains unresolved. The DNA replication stress response protein SMARCAL1 stabilizes DNA replication forks and prevents replication fork collapse, a cause of DNA b... | Defective replication stress response inhibits lymphomagenesis and impairs lymphocyte reconstitution |
{"1011": 0.2470736801624298, "1039": 0.8366385698318481, "1043": 0.1710275560617447, "1998": 0.04674193635582924, "2003": 0.28963330388069153, "2010": 0.6624060273170471, "2013": 0.12038381397724152, "2029": 0.11430477350950241, "2033": 0.37974658608436584, "2034": 0.3995884954929352, "2054": 0.004870930220931768, "207... | 3174305 | DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular processes including genome regulation, development and disease. Here we present the first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fe... | Human DNA methylomes at base resolution show widespread epigenomic differences |
{"1014": 0.5415972471237183, "1052": 0.18167030811309814, "1053": 0.2983669638633728, "1058": 0.15526613593101501, "1997": 0.05970508232712746, "2004": 0.30989447236061096, "2005": 0.30558720231056213, "2007": 0.09406650811433792, "2015": 0.2763880789279938, "2044": 0.018384648486971855, "2051": 0.20102575421333313, "2... | 3190689 | BACKGROUND Laparoscopic adhesiolysis for chronic abdominal pain is controversial and is not evidence based. We aimed to test our hypothesis that laparoscopic adhesiolysis leads to substantial pain relief and improvement in quality of life in patients with adhesions and chronic abdominal pain. METHODS Patients had diagn... | Laparoscopic adhesiolysis in patients with chronic abdominal pain: a blinded randomised controlled multi-centre trial. |
{"1011": 0.3106105625629425, "1015": 0.4914994537830353, "1016": 0.3409265875816345, "1039": 0.6441128253936768, "1040": 0.2786078155040741, "1041": 0.30989447236061096, "1045": 0.7210738658905029, "1998": 0.09938567131757736, "2005": 0.09761575609445572, "2015": 0.0354953333735466, "2028": 0.14349138736724854, "2029":... | 3202143 | Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and memory are unknown. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improves memory performanc... | Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age |
{"1011": 0.27712854743003845, "1017": 0.17922431230545044, "1023": 0.5963221788406372, "1054": 1.0193830728530884, "1056": 0.4944818615913391, "1060": 0.7105726003646851, "1998": 0.025073638185858727, "2003": 0.2034190446138382, "2007": 0.3554046154022217, "2008": 0.06246116757392883, "2029": 0.27564704418182373, "2035... | 3203590 | Heterodimerization is a common paradigm among eukaryotic transcription factors. The 9-cis retinoic acid receptor (RXR) serves as a common heterodimerization partner for several nuclear receptors, including the thyroid hormone receptor (T3R) and retinoic acid receptor (RAR). This raises the question as to whether these ... | Unique response pathways are established by allosteric interactions among nuclear hormone receptors |
{"1011": 0.0058422754518687725, "1017": 0.2667117714881897, "1019": 0.37907835841178894, "1044": 0.22079704701900482, "1056": 0.31132611632347107, "1059": 1.162295937538147, "2007": 0.11168810725212097, "2012": 0.32129061222076416, "2019": 0.4374985992908478, "2029": 0.056018441915512085, "2039": 0.15275461971759796, "... | 3205945 | BACKGROUND Diffusion tensor imaging measures of white matter (WM) microstructural integrity appear to provide earlier indication of WM injury than WM hyperintensities; however, risk factors for poor WM microstructural integrity have not been established. Our study quantifies the association between vascular risk factor... | Midlife and Late‐Life Vascular Risk Factors and White Matter Microstructural Integrity: The Atherosclerosis Risk in Communities Neurocognitive Study |
{"1003": 0.058784693479537964, "1043": 0.3560888469219208, "1047": 1.2158164978027344, "1058": 0.24248650670051575, "2006": 0.41840189695358276, "2007": 0.02412080205976963, "2010": 0.5461324453353882, "2012": 0.058784693479537964, "2020": 0.022212404757738113, "2042": 0.08513788133859634, "2050": 0.012615402229130268,... | 3210545 | BACKGROUND Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma viral oncogenes homologue (KRAS) mutations have been reported to have an important role in tumor... | KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer |
{"1042": 0.8433839678764343, "1044": 0.757441520690918, "2000": 0.09584271162748337, "2003": 0.083342544734478, "2004": 0.026025565341114998, "2005": 0.4938860833644867, "2012": 0.347847044467926, "2080": 0.26446542143821716, "2094": 0.2659635543823242, "2109": 0.12642613053321838, "2116": 0.18816383183002472, "2140": ... | 3215494 | Hyperhomocysteinemia has recently been identified as an important risk factor for atherosclerotic vascular disease. This article reviews homocysteine metabolism, causes of hyperhomocysteinemia, the pathophysiological findings of this disorder, and epidemiological studies of homocysteine and vascular disease. Screening ... | Hyperhomocysteinemia and atherosclerotic vascular disease: pathophysiology, screening, and treatment. off. |
{"1011": 0.24631060659885406, "1040": 0.14433705806732178, "1053": 0.5833279490470886, "1997": 0.6244332790374756, "2045": 0.09850110858678818, "2051": 0.5461324453353882, "2058": 0.09317722171545029, "2062": 0.49923527240753174, "2063": 1.1629066467285156, "2064": 0.371698260307312, "2066": 0.04207121208310127, "2071"... | 3222122 | Statements like "quality of care is more highly valued than waiting time" can neither be supported nor refuted by comparisons of utility parameters from a traditional discrete choice experiment (DCE). Best--worst scaling can overcome this problem because it asks respondents to perform a different choice task. However, ... | Best--worst scaling: What it can do for health care research and how to do it. |
{"1015": 0.02316705882549286, "1016": 0.09761575609445572, "1038": 0.5461324453353882, "1040": 1.094698429107666, "1043": 0.9635916948318481, "1055": 0.37974658608436584, "1999": 0.18004031479358673, "2007": 0.3877306580543518, "2013": 0.03831886500120163, "2015": 0.11081436276435852, "2020": 0.07159364968538284, "2029... | 3222187 | Genome-wide association studies (GWAS) have identified common polymorphisms in or near GC, CYP2R1, CYP24A1, and NADSYN1/DHCR7 genes to be associated with circulating levels of 25-hydroxyvitamin D [25(OH)D] in European populations. To replicate these GWAS findings, we examined six selected polymorphisms from these regio... | Genetic variants and non-genetic factors predict circulating vitamin D levels in Hispanic and non-Hispanic White women: the Breast Cancer Health Disparities Study. |
{"1011": 0.43623676896095276, "1023": 0.1401015669107437, "1043": 0.3027053773403168, "1044": 0.5618454217910767, "1047": 0.6613984704017639, "1048": 0.7755908370018005, "1057": 0.32129061222076416, "1059": 0.7942996621131897, "1999": 0.058784693479537964, "2002": 0.23324857652187347, "2005": 0.1401015669107437, "2006"... | 3230361 | Publisher Summary This chapter summarizes the development and characterization of rabbit polyclonal antibodies named histone that are directed against the methylated H3-K9 position. It provides protocols for peptide design, rabbit immunizations, and quality controls of methyl-lysine histone antibodies, followed by thei... | Generation and characterization of methyl-lysine histone antibodies. |
{"1023": 0.304147332906723, "1997": 0.31204116344451904, "2003": 0.14095009863376617, "2011": 0.3005385100841522, "2012": 0.25694093108177185, "2015": 0.33953672647476196, "2038": 0.004870930220931768, "2054": 0.5930894017219543, "2057": 0.2247048318386078, "2070": 0.2394166737794876, "2075": 0.07612881064414978, "2076... | 3230557 | Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has ... | The Hallmarks of Aging |
{"1011": 0.04953393340110779, "1039": 0.6128603219985962, "1041": 0.3170322775840759, "1043": 0.2763880789279938, "1049": 0.026025565341114998, "2000": 0.016465263441205025, "2003": 0.06703783571720123, "2005": 0.1602703034877777, "2015": 0.029824240133166313, "2057": 0.04207121208310127, "2064": 0.14686977863311768, "... | 3270834 | Abnormal nutrient metabolism is a hallmark of aging, and the underlying genetic and nutritional framework is rapidly being uncovered, particularly using C. elegans as a model. However, the direct metabolic consequences of perturbations in life history of C. elegans remain to be clarified. Based on recent advances in th... | A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans |
{"1003": 0.08871890604496002, "1016": 0.2105647772550583, "1040": 0.01934296265244484, "1047": 0.030771657824516296, "1052": 0.04953393340110779, "1058": 0.8383291959762573, "2000": 0.016465263441205025, "2004": 0.037378571927547455, "2005": 0.47158926725387573, "2006": 0.01934296265244484, "2007": 0.23324857652187347,... | 3272084 | Inappropriate use of antibiotics is contributing to the increasing rates of antimicrobial resistance. Several Danish guidelines on antibiotic prescribing for acute respiratory tract infections in general practice have been issued to promote rational prescribing of antibiotics, however it is unclear if these recommendat... | Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice: a retrospective registry based cohort study |
{"1011": 0.39367714524269104, "1020": 1.036847710609436, "1040": 0.23479416966438293, "1052": 0.7463917136192322, "1998": 0.0009760859538801014, "1999": 0.19782574474811554, "2004": 0.007782140281051397, "2012": 0.36290550231933594, "2029": 0.3077431619167328, "2039": 0.20818853378295898, "2043": 0.0752234235405922, "2... | 3285059 | Pyruvate dehydrogenase (PDH) plays a key role in the regulation of skeletal muscle substrate utilization. IL-6 is produced in skeletal muscle during exercise in a duration dependent manner and has been reported to increase whole body fatty acid oxidation, muscle glucose uptake and decrease PDHa activity in skeletal mus... | Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise |
{"1011": 0.04207121208310127, "1015": 0.32129061222076416, "1016": 0.24325250089168549, "1017": 0.11691460013389587, "1026": 0.22548456490039825, "1052": 0.39433568716049194, "1998": 0.08961215615272522, "2001": 0.02316705882549286, "2007": 0.28450319170951843, "2010": 0.5255602598190308, "2014": 0.7728893756866455, "2... | 3285322 | PURPOSE Mutations in the BRCA1 and BRCA2 genes confer greater risk of developing breast cancer. We determined whether tumor pathologic features and clinical features differ in patients with and without BRCA mutations. PATIENTS AND METHODS Tumor pathologic features and clinical characteristics were examined in 491 women... | Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer. |
{"1015": 0.5151132941246033, "1016": 0.004870930220931768, "1017": 0.30558720231056213, "1038": 0.28082266449928284, "1039": 0.6022219061851501, "1043": 0.4437839686870575, "1044": 0.23092569410800934, "1045": 0.777387797832489, "1996": 0.10993985831737518, "2002": 0.7755908370018005, "2003": 0.2145126610994339, "2004"... | 3308636 | The interferons (IFNs) are glycoproteins with strong antiviral activities that represent one of the first lines of host defense against invading pathogens. These proteins are classified into three groups, Type I, II and III IFNs, based on the structure of their receptors on the cell surface. Due to their ability to mod... | Interferons: Success in anti-viral immunotherapy. |
{"2013": 0.4093637466430664, "2020": 0.15359249711036682, "2042": 0.1946154683828354, "2058": 0.43875885009765625, "2071": 0.00875066313892603, "2073": 0.18816383183002472, "2082": 0.6043586730957031, "2106": 0.11951763927936554, "2111": 0.08603433519601822, "2116": 0.4879087805747986, "2155": 0.7898768186569214, "2177... | 3315558 | An analysis of the genetic factors in obesity has been carried out on a sample of nuclear families from Aosta (N. Italy). The families consisted of the parents and sibs of all elementary school children considered to be obese during a preliminary screening and a similar sample of non-obese children and their nuclear fa... | Genetic analysis of human obesity in an Italian sample. |
{"1011": 0.22704219818115234, "1044": 0.24018502235412598, "1050": 0.6867793202400208, "2002": 0.32199856638908386, "2004": 0.04207121208310127, "2015": 0.4974553883075714, "2024": 0.0029254043474793434, "2025": 0.42608439922332764, "2026": 0.5209306478500366, "2029": 0.2034190446138382, "2053": 0.8091925978660583, "20... | 3321943 | Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are incompletely understood. Here we present a comprehensive resource defining the non-coding RNA landscape of the hu... | The non-coding RNA landscape of human hematopoiesis and leukemia |
{"1011": 0.21530038118362427, "1014": 0.08782484382390976, "1039": 0.04767346754670143, "1052": 0.2652147710323334, "1062": 0.13670019805431366, "2004": 0.2741633653640747, "2007": 0.11081436276435852, "2014": 1.076228141784668, "2015": 0.6709295511245728, "2025": 0.1229778528213501, "2034": 0.7009293437004089, "2039":... | 3329824 | BACKGROUND Central nervous system (CNS) disease as the site of first relapse after exposure to adjuvant trastuzumab has been reported. We carried out comprehensive meta-analysis to determine the risk of CNS metastases as the first site of recurrence in patients with HER2-positive breast cancer who received adjuvant tra... | Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab. |
{"1041": 0.026025565341114998, "1050": 0.1685553640127182, "1996": 0.2531573474407196, "1999": 0.10731173306703568, "2004": 0.0058422754518687725, "2011": 0.15023678541183472, "2015": 0.49626702070236206, "2024": 0.13414156436920166, "2029": 0.15359249711036682, "2047": 0.13499516248703003, "2076": 0.0913962796330452, ... | 3330111 | Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, more recent evidence has extended the functions of these cells. The newly discovered repertoire of effector molecules in the neutrophil armamentarium... | Neutrophils in the activation and regulation of innate and adaptive immunity |
{"1019": 0.49864232540130615, "1049": 0.0009760859538801014, "1997": 0.05417001247406006, "1998": 0.29036402702331543, "2001": 0.2184450328350067, "2003": 0.1384023278951645, "2029": 0.1873544454574585, "2033": 0.3588210940361023, "2034": 0.04860413447022438, "2043": 0.3346569836139679, "2054": 0.08064348995685577, "20... | 3346812 | DNA methylation is frequently described as a 'silencing' epigenetic mark, and indeed this function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved genome-scale mapping of methylation, we can evaluate DNA methylation in different genomic contexts: transcriptional start sites with or wit... | Functions of DNA methylation: islands, start sites, gene bodies and beyond |
{"1997": 0.10203468054533005, "2000": 0.15693697333335876, "2011": 0.07431721687316895, "2013": 0.41195443272590637, "2028": 0.5110208988189697, "2039": 0.09938567131757736, "2046": 0.5278670787811279, "2047": 0.27786844968795776, "2048": 0.0019512200960889459, "2052": 0.26446542143821716, "2054": 0.09317722171545029, ... | 3353748 | Transformations from one tissue type to another make up a well established set of phenomena that can be explained by the principles of developmental biology. Although these phenomena might be rare in nature, we can now imagine the possibility of deliberately reprogramming cells from one tissue type to another by manipu... | Metaplasia and transdifferentiation: from pure biology to the clinic |
{"1048": 0.19381128251552582, "1052": 0.5336109399795532, "1060": 0.05694137513637543, "1062": 0.02316705882549286, "2004": 0.04487626627087593, "2005": 0.4228905141353607, "2050": 0.2516399025917053, "2051": 0.06795065850019455, "2053": 0.47463157773017883, "2064": 0.26446542143821716, "2080": 0.09850110858678818, "20... | 3355397 | IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. DESIGN, SETTING, AND PARTICIPANTS Cohort and nested case-control analyses among persons with diabetes. A bladder cancer cohor... | Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes. |
{"1011": 0.14518201351165771, "1016": 0.022212404757738113, "1017": 0.015504186972975731, "1018": 0.1212492436170578, "1041": 0.8332487344741821, "1998": 0.06703783571720123, "2005": 0.19782574474811554, "2013": 0.5871354341506958, "2015": 0.010684899985790253, "2024": 0.07250232994556427, "2029": 0.2539152204990387, "... | 3360421 | We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while maintaining expression of markers characteristic of pluripotent primate cells. Human ES cells express the transcription factor Oct-4, essential f... | Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro |
{"1011": 0.0029254043474793434, "1014": 0.2105647772550583, "1043": 0.4330752193927765, "1047": 1.2964379787445068, "1050": 0.5069117546081543, "1051": 0.48850810527801514, "1058": 0.3134697377681732, "2003": 0.22937409579753876, "2010": 0.6000806093215942, "2029": 0.04674193635582924, "2072": 0.14349138736724854, "207... | 3360428 | Kras mutation is a common phenomenon in many human neoplasms. We aimed to assess the Kras mutational status along the histological continuum from normal ovaries to the development of benign, borderline and malignant ovarian mucinous neoplasms. We analyzed 41 cases of malignant, 10 cases of borderline, 7 cases of benign... | Multipoint Kras oncogene mutations potentially indicate mucinous carcinoma on the entire spectrum of mucinous ovarian neoplasms |
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