spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1040": 0.09584271162748337, "1052": 0.2786078155040741, "2003": 0.11691460013389587, "2011": 0.0317181795835495, "2028": 0.1718502640724182, "2037": 0.021256839856505394, "2038": 0.04674193635582924, "2046": 0.03266380727291107, "2048": 0.056018441915512085, "2050": 0.520350456237793, "2052": 0.29255300760269165, "20... | 2140513 | Most genes affect many traits. This phenomenon, known as pleiotropy, is a major constraint on evolution because adaptive change in one trait may be prevented because it would compromise other traits affected by the same genes. Here we show that pleiotropy can have an unexpected effect and benefit one of the most enigma... | Pleiotropy as a mechanism to stabilize cooperation |
{"1011": 0.06612417846918106, "1039": 0.2160874605178833, "1043": 0.9455460906028748, "1055": 0.11778303235769272, "1060": 0.6704301834106445, "1996": 0.07612881064414978, "2003": 0.22001366317272186, "2008": 0.026976587250828743, "2029": 0.12470348179340363, "2051": 0.1718502640724182, "2058": 0.23787821829319, "2073"... | 2147704 | Goosecoid (gsc), a homeobox gene expressed specifically in the dorsal blastopore lip of the Xenopus gastrula, is considered to play an important role in Spemann's organizer phenomenon. Lineage tracing and time-lapse microscopy were used to follow the fate of embryonic cells microinjected with gsc mRNA. Microinjected gs... | The homeobox gene goosecoid controls cell migration in Xenopus embryos. |
{"1011": 0.14686977863311768, "1044": 0.29109421372413635, "1048": 0.2105647772550583, "1056": 1.0471819639205933, "2008": 0.08782484382390976, "2010": 0.7342816591262817, "2011": 0.37035053968429565, "2012": 0.036437395960092545, "2024": 0.04767346754670143, "2029": 0.175953671336174, "2046": 0.10993985831737518, "207... | 2151983 | Transcription factors (TFs) bind specifically to discrete regions of mammalian genomes called cis-regulatory elements. Among those are enhancers, which play key roles in regulation of gene expression during development and differentiation. Despite the recognized central regulatory role exerted by chromatin in control o... | Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers. |
{"1048": 0.3127557039260864, "2005": 0.2026219218969345, "2044": 0.18004031479358673, "2051": 0.15275461971759796, "2058": 0.1485546976327896, "2064": 0.14602625370025635, "2066": 0.5816917419433594, "2076": 0.07159364968538284, "2078": 0.03831886500120163, "2106": 0.07068414986133575, "2109": 0.18816383183002472, "211... | 2158500 | We investigated whether or not administered leptin influences anxiety-like behavior in ob/ob mice. Repeated intraperitoneal administrations of leptin were continued for 5 days. Anxiety was assessed in the standard elevated plus maze. Body weight was measured daily. Repeated administrations of leptin significantly incre... | Leptin treatment ameliorates anxiety in ob/ob obese mice. |
{"1011": 0.09495500475168228, "1019": 0.20102575421333313, "1040": 0.906871497631073, "1044": 0.32553088665008545, "1050": 0.22937409579753876, "1998": 0.304147332906723, "2002": 0.010684899985790253, "2006": 0.1384023278951645, "2007": 0.35403475165367126, "2010": 0.6911921501159668, "2011": 0.2852376699447632, "2020"... | 2158516 | Although drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug-target combinations exist, it would be useful to explore possible interactions computationally. Here we compared 3,665 US Food and Drug Administration (FDA)-approved ... | Predicting new molecular targets for known drugs |
{"1039": 0.37371641397476196, "1040": 0.5936289429664612, "1043": 0.175953671336174, "1047": 0.28082266449928284, "1051": 0.07341018319129944, "1058": 1.001607894897461, "1998": 0.03925827145576477, "2003": 0.24325250089168549, "2004": 0.1011524572968483, "2010": 0.5528968572616577, "2054": 0.27564704418182373, "2076":... | 2159648 | Vascular calcification (VC) represents a recognized adverse predictor for cardiovascular morbidity and mortality. Previously considered passive and degenerative, VC is now recognized as an active process that resembles bone formation, and shares a number of histopathological features, mineral composition, and initiatio... | Bone loss and vascular calcification: A bi-directional interplay? |
{"1011": 0.21372433006763458, "1021": 0.32129061222076416, "1039": 0.3824150264263153, "1048": 0.3777405619621277, "2002": 0.7665573358535767, "2007": 0.012615402229130268, "2011": 0.18492233753204346, "2015": 0.32129061222076416, "2029": 0.30989447236061096, "2048": 0.021256839856505394, "2063": 0.3297532796859741, "2... | 2177022 | Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic cell (DC) migration, we showed that these distinct cellular responses depended on the mode of chemokine presentation within tissues. The surfa... | Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. |
{"1996": 0.04674193635582924, "1999": 0.2822965085506439, "2012": 0.6059582233428955, "2029": 0.07068414986133575, "2039": 0.04860413447022438, "2043": 0.17840765416622162, "2058": 0.6471850275993347, "2073": 0.30558720231056213, "2076": 0.4849066734313965, "2079": 0.16110190749168396, "2083": 0.1011524572968483, "2146... | 2192419 | During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall. The observation that circulating monocytes give rise to lesional macrophages has reinforced the concept that monocyte infiltration dictates macrophage buildup. Recent work has indicated, howe... | Local proliferation dominates lesional macrophage accumulation in atherosclerosis |
{"1011": 0.17267228662967682, "1038": 0.6389714479446411, "1040": 0.5421652793884277, "1048": 0.5827828645706177, "1999": 0.21530038118362427, "2006": 0.12470348179340363, "2007": 0.0029254043474793434, "2008": 0.04207121208310127, "2010": 0.6160298585891724, "2011": 0.2409527748823166, "2013": 0.13243216276168823, "20... | 2194320 | The formation of beta-amyloid in the brains of individuals with Alzheimer disease requires the proteolytic cleavage of a membrane-associated precursor protein. The proteases that may be involved in this process have not yet been identified. Cathepsins are normally intracellular proteolytic enzymes associated with lysos... | Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. |
{"1011": 0.347847044467926, "1014": 0.39893341064453125, "1015": 0.3757305145263672, "1016": 0.29255300760269165, "1017": 0.6813592314720154, "1043": 0.1718502640724182, "1049": 0.18329764902591705, "2004": 0.06520967930555344, "2005": 0.38574060797691345, "2011": 0.09406650811433792, "2012": 0.37035053968429565, "2015... | 2205779 | MicroRNAs (miRNAs) play crucial roles during the occurrence and development of gastric cancer. Conventional serological tests for screening gastric cancer have limits on sensitivity and specificity. Several miRNAs in peripheral blood have been used as biomarkers of gastric cancer. However, most of these miRNAs are shar... | Gastric juice miR-129 as a potential biomarker for screening gastric cancer |
{"1011": 0.3325583338737488, "1015": 0.25239890813827515, "1038": 0.2822965085506439, "1041": 0.6764062643051147, "1047": 0.44566190242767334, "1048": 0.34370049834251404, "1049": 0.13157635927200317, "1050": 0.777387797832489, "1155": 0.0770333781838417, "1156": 1.197703242301941, "2015": 0.2247048318386078, "2029": 0... | 2211868 | β-Lactamase evolution presents to the infectious disease community a major challenge in the treatment of infections caused by multidrug-resistant gram-negative bacteria. Because over 1,000 of these naturally occurring β-lactamases exist, attempts to correlate structure and function have become daunting. Although new en... | Epidemiological expansion, structural studies, and clinical challenges of new β-lactamases from gram-negative bacteria. |
{"1011": 0.08871890604496002, "1015": 0.06703783571720123, "1017": 0.32270604372024536, "1061": 0.5220900774002075, "1997": 0.03360854089260101, "1998": 0.45251765847206116, "2003": 0.021256839856505394, "2011": 0.10203468054533005, "2024": 0.1064341589808464, "2028": 0.1946154683828354, "2029": 0.21372433006763458, "2... | 2212067 | Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead to synchronization. Here, we estimated the mutual interactions between the two oscillators by time-lapse imaging of single mammalian NIH3T3 fibroblasts during ... | Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells |
{"1040": 0.05046287178993225, "1043": 0.44566190242767334, "1044": 0.1602703034877777, "1996": 0.3077431619167328, "1999": 0.03266380727291107, "2008": 0.02792670577764511, "2011": 0.28082266449928284, "2029": 0.14095009863376617, "2037": 0.083342544734478, "2060": 0.22001366317272186, "2073": 0.12470348179340363, "207... | 2225918 | Hunger, driven by negative energy balance, elicits the search for and consumption of food. While this response is in part mediated by neurons in the hypothalamus, the role of specific cell types in other brain regions is less well defined. Here, we show that neurons in the dorsal raphe nucleus, expressing vesicular tra... | Identification of a Brainstem Circuit Controlling Feeding |
{"1048": 0.6348392367362976, "1050": 0.022212404757738113, "2011": 0.25467249751091003, "2015": 0.13243216276168823, "2020": 0.02316705882549286, "2025": 0.4337083101272583, "2029": 0.036437395960092545, "2042": 0.28155985474586487, "2043": 0.09050461649894714, "2046": 0.2409527748823166, "2066": 0.10467668622732162, "... | 2236768 | Neutrophil extracellular traps (NETs) are released as neutrophils die in vitro in a process requiring hours, leaving a temporal gap that invasive microbes may exploit. Neutrophils capable of migration and phagocytosis while undergoing NETosis have not been documented. During Gram-positive skin infections, we directly v... | Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo |
{"1014": 0.10467668622732162, "1019": 0.0317181795835495, "1020": 0.3177432417869568, "1059": 0.7076893448829651, "1060": 0.1946154683828354, "1999": 0.5051454305648804, "2010": 0.3170322775840759, "2011": 0.0038986403960734606, "2020": 0.11081436276435852, "2044": 0.3127557039260864, "2051": 0.3963087201118469, "2075"... | 2242416 | The present study was designed to determine the effects of physical training on the development of cancer induced by the injection of Ehrlich tumor cells in mice. Male Swiss mice were subjected to a swim training protocol (5 days/wk for 6 wk, 1 h at 50% of maximal capacity-trained groups) or remained sedentary in their... | Swim training suppresses tumor growth in mice. |
{"1011": 0.11778303235769272, "1018": 0.38174858689308167, "1039": 0.0913962796330452, "1040": 0.18654440343379974, "1056": 1.094698429107666, "1996": 0.0009760859538801014, "2004": 0.053244512528181076, "2005": 0.2018241584300995, "2011": 0.2637155055999756, "2015": 0.75193190574646, "2029": 0.19622190296649933, "2046... | 2248870 | T cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) imprint T cell lung homing, as lung DC-activated T cells traffic more efficiently into the lung in response to inhaled antigen and at ... | Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4 |
{"1011": 0.007782140281051397, "1999": 0.03831886500120163, "2004": 0.06246116757392883, "2005": 0.11951763927936554, "2007": 0.08782484382390976, "2008": 0.20022670924663544, "2011": 0.06337817758321762, "2015": 0.4337083101272583, "2024": 0.13243216276168823, "2029": 0.2881702482700348, "2043": 0.11256109178066254, "... | 2251426 | Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during stress. This might be partially explained b... | microRNAs: A Safeguard against Turmoil? |
{"1011": 0.31560876965522766, "1017": 0.32341301441192627, "1037": 0.2493593990802765, "1058": 0.35060185194015503, "1155": 0.18816383183002472, "2004": 0.18654440343379974, "2007": 0.0797421783208847, "2008": 0.0019512200960889459, "2011": 0.47827014327049255, "2013": 0.00875066313892603, "2015": 0.8633513450622559, "... | 2260571 | RATIONALE Matrix vesicles (MVs), secreted by vascular smooth muscle cells (VSMCs), form the first nidus for mineralization and fetuin-A, a potent circulating inhibitor of calcification, is specifically loaded into MVs. However, the processes of fetuin-A intracellular trafficking and MV biogenesis are poorly understood.... | Vascular smooth muscle cell calcification is mediated by regulated exosome secretion. |
{"1017": 0.3034266233444214, "1042": 0.011650617234408855, "1052": 0.04394211992621422, "1998": 0.03360854089260101, "2000": 0.09317722171545029, "2005": 0.20501139760017395, "2021": 0.012615402229130268, "2038": 0.14686977863311768, "2045": 0.7389566898345947, "2047": 0.45437926054000854, "2053": 0.3923587501049042, "... | 2264455 | There is no licenced vaccine against any human parasitic disease and Plasmodium falciparum malaria, a major cause of infectious mortality, presents a great challenge to vaccine developers. This has led to the assessment of a wide variety of approaches to malaria vaccine design and development, assisted by the availabil... | Vaccines against malaria |
{"1011": 0.29473719000816345, "1048": 0.6054253578186035, "1052": 0.07159364968538284, "1053": 0.6212902665138245, "2003": 0.10291612148284912, "2007": 0.20660123229026794, "2011": 0.40285754203796387, "2015": 0.15275461971759796, "2029": 0.19782574474811554, "2034": 0.1718502640724182, "2039": 0.42416930198669434, "20... | 2266471 | Lymphangioleiomyomatosis (LAM), a multisystem disease of women, is manifest by the proliferation of smooth muscle-like cells in the lung resulting in cystic lung destruction. Women with LAM can also develop renal angiomyolipomas. LAM is caused by mutations in the tuberous sclerosis complex genes (TSC1 or TSC2), resulti... | MicroRNA-21 is Induced by Rapamycin in a Model of Tuberous Sclerosis (TSC) and Lymphangioleiomyomatosis (LAM) |
{"1011": 0.036437395960092545, "1041": 0.9857001900672913, "1043": 0.08692999184131622, "1050": 0.43812891840934753, "1056": 0.8039615154266357, "2007": 0.28597161173820496, "2008": 0.009718249551951885, "2011": 0.2576959431171417, "2029": 0.29473719000816345, "2033": 0.9455460906028748, "2087": 0.1718502640724182, "20... | 2272614 | Activating mutations in the EGF receptor (EGFR) are associated with clinical responsiveness to EGFR tyrosine kinase inhibitors (TKI), such as erlotinib and gefitinib. However, resistance eventually arises, often due to a second EGFR mutation, most commonly T790M. Through a genome-wide siRNA screen in a human lung cance... | Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. |
{"1011": 0.26296505331993103, "1015": 0.1212492436170578, "1043": 0.6543170213699341, "1048": 0.7445381283760071, "1052": 0.7463917136192322, "2005": 0.18004031479358673, "2008": 0.03831886500120163, "2026": 0.7163142561912537, "2029": 0.44753631949424744, "2030": 0.22392450273036957, "2063": 0.1384023278951645, "2076"... | 2274272 | Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We ... | Human IRGM induces autophagy to eliminate intracellular mycobacteria. |
{"1003": 0.052318159490823746, "1052": 0.03266380727291107, "2001": 0.1477125883102417, "2020": 0.1221139207482338, "2034": 0.0354953333735466, "2043": 0.21530038118362427, "2072": 0.401551216840744, "2073": 0.35403475165367126, "2076": 0.1808556467294693, "2082": 0.5324648022651672, "2087": 0.14349138736724854, "2095"... | 2276126 | The aim of this study was to provide a clinical pharmacy education program at Masih Daneshvari hospital, a University affiliated hospital, located in Tehran, Iran. For this purpose, the most common pharmacist involved interventions and aspects of potential fields for pharmacy students and residents education was firstl... | Implementation of a Clinical Pharmacy Education Program in a Teaching Hospital: Resident Oriented Documentation and Intervention |
{"1011": 0.2184450328350067, "1996": 0.6043586730957031, "1997": 0.021256839856505394, "1998": 0.16690383851528168, "1999": 0.12986256182193756, "2006": 0.1229778528213501, "2012": 0.8383291959762573, "2029": 0.1734936386346817, "2033": 0.5838727951049805, "2045": 0.09584271162748337, "2049": 0.09850110858678818, "2064... | 2291922 | On the basis of our collective experience we have reviewed the disposition of the cardiac conduction tissues as they might be observed by the surgeon in both normal and abnormal hearts. The sinus node lies subepicardially in the terminal sulcus; because of its variable blood supply the entire superior cavoatrial juncti... | The surgical anatomy of the conduction tissues. |
{"1011": 0.015504186972975731, "1014": 0.4450363218784332, "1041": 0.7755908370018005, "1042": 0.603290855884552, "1044": 0.1485546976327896, "1047": 0.47827014327049255, "1052": 0.1358480453491211, "2000": 0.1064341589808464, "2001": 0.05417001247406006, "2003": 0.28155985474586487, "2010": 0.08064348995685577, "2026"... | 2295434 | myfood24 Is an online 24-h dietary assessment tool developed for use among British adolescents and adults. Limited information is available regarding the validity of using new technology in assessing nutritional intake among adolescents. Thus, a relative validation of myfood24 against a face-to-face interviewer-adminis... | Agreement between an online dietary assessment tool (myfood24) and an interviewer-administered 24-h dietary recall in British adolescents aged 11-18 years. |
{"1998": 0.13755162060260773, "2000": 0.7881022095680237, "2004": 0.5751199722290039, "2005": 0.4500300884246826, "2007": 0.28082266449928284, "2011": 0.07884006202220917, "2029": 0.0797421783208847, "2038": 0.10906458646059036, "2044": 0.1011524572968483, "2064": 0.3416208028793335, "2076": 0.01934296265244484, "2078"... | 2296264 | Biochemical modulation has played an important role in the development of cancer chemotherapy. We have directed our attention to the intake of common beverages and investigated the effects of green tea and tea components on the antitumor activity of doxorubicin. We carried out the combined treatment of toxorubicin and ... | Modulation of cancer chemotherapy by green tea. |
{"1011": 0.10467668622732162, "1016": 0.42735910415649414, "1019": 0.3982778787612915, "1039": 0.2852376699447632, "1047": 1.086165428161621, "2007": 0.3870677351951599, "2010": 0.5284429788589478, "2012": 0.3963087201118469, "2029": 0.20660123229026794, "2057": 0.4980490207672119, "2058": 0.31560876965522766, "2066": ... | 2316374 | AIMS Vascular endothelial dysfunction and inflammation are hallmarks of atherosclerosis. Krüppel-like factor 2 (KLF2) is a key mediator of anti-inflammatory and anti-atherosclerotic properties of the endothelium. However, little is known of the molecular mechanisms for regulating KLF2 transcriptional activation. METHOD... | Histone deacetylase 5 interacts with Krüppel-like factor 2 and inhibits its transcriptional activity in endothelium. |
{"1009": 0.2493593990802765, "1011": 0.0009760859538801014, "1015": 0.6286086440086365, "1022": 0.4980490207672119, "1041": 0.5871354341506958, "1044": 0.5376120805740356, "1050": 0.7942996621131897, "1054": 0.021256839856505394, "2028": 0.1873544454574585, "2029": 0.18167030811309814, "2038": 0.04113444685935974, "206... | 2319305 | Drug resistance-associated mutations in HIV-1 reverse transcriptase (RT) can affect the balance between polymerase and ribonuclease H (RNase H) activities of the enzyme. We have recently demonstrated that the N348I mutation in the connection domain causes selective dissociation from RNase H-competent complexes, whereas... | N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation. |
{"1003": 0.11343330889940262, "1004": 0.15693697333335876, "1017": 0.3070250153541565, "1019": 0.11778303235769272, "1038": 0.16110190749168396, "2000": 0.20102575421333313, "2006": 0.19622190296649933, "2020": 0.05694137513637543, "2022": 0.07341018319129944, "2039": 0.1994270235300064, "2044": 0.19622190296649933, "2... | 2328272 | INTRODUCTION With the growing number of adult cancer survivors, there is increasing need for information that links potential late and long term effects with specific treatment regimens. Few adult cancer patients are treated on clinical trials; however, patients previously enrolled in these trials are an important sour... | Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group |
{"1038": 0.7028654217720032, "2000": 0.08603433519601822, "2005": 0.38308101892471313, "2007": 0.06429435312747955, "2011": 0.053244512528181076, "2029": 0.21372433006763458, "2044": 0.8195732831954956, "2046": 0.1873544454574585, "2051": 0.12470348179340363, "2062": 0.08244366943836212, "2067": 0.5635144114494324, "20... | 2335873 | Bacterial chondroitinase ABC (ChaseABC) has been used to remove the inhibitory chondroitin sulfate chains from chondroitin sulfate proteoglycans to improve regeneration after rodent spinal cord injury. We hypothesized that the mammalian enzyme arylsulfatase B (ARSB) would also enhance recovery after mouse spinal cord i... | Arylsulfatase B Improves Locomotor Function after Mouse Spinal Cord Injury |
{"1011": 0.09761575609445572, "1014": 0.5116065740585327, "1020": 0.5069117546081543, "1044": 0.020300358533859253, "1054": 0.8400169610977173, "1055": 0.08603433519601822, "1058": 0.46117570996284485, "2004": 1.1858406066894531, "2007": 0.1710275560617447, "2040": 0.8666408061981201, "2041": 0.6207655072212219, "2051"... | 2338488 | BACKGROUND A self-report screening scale of adult attention-deficit/hyperactivity disorder (ADHD), the World Health Organization (WHO) Adult ADHD Self-Report Scale (ASRS) was developed in conjunction with revision of the WHO Composite International Diagnostic Interview (CIDI). The current report presents data on concor... | The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population. |
{"1011": 0.16607704758644104, "1038": 0.2034190446138382, "1040": 0.04674193635582924, "1041": 0.4831010699272156, "1043": 0.3526630103588104, "1044": 0.5045560002326965, "1048": 0.777387797832489, "1997": 0.10026945173740387, "1999": 0.2493593990802765, "2005": 0.17922431230545044, "2012": 0.13755162060260773, "2015":... | 2344892 | Human milk contains nutrients and bioactive products relevant to infant development and immunological protection. Here, we investigated the proresolving properties of milk using human milk lipid mediator isolates (HLMIs) and determined their impact on resolution programs in vivo and with human macrophages. HLMIs reduce... | Human milk proresolving mediators stimulate resolution of acute inflammation |
{"1037": 0.15526613593101501, "2003": 0.3416208028793335, "2007": 0.0174254160374403, "2011": 0.04767346754670143, "2022": 0.10555581003427505, "2035": 0.040196798741817474, "2054": 0.6568518877029419, "2129": 0.083342544734478, "2132": 0.09050461649894714, "2303": 0.11081436276435852, "2319": 0.045809537172317505, "23... | 2352142 | Stroke is a heterogeneous syndrome caused by multiple disease mechanisms, but all result in a disruption of cerebral blood flow with subsequent tissue damage. This review covers the mechanisms responsible for regulation of the normal cerebral circulation, and how they are disrupted in disease states. A central concept ... | Cerebral perfusion and stroke. |
{"1011": 0.27342069149017334, "1015": 0.5057345628738403, "1049": 0.3897167444229126, "2008": 0.08244366943836212, "2011": 0.25694093108177185, "2019": 0.8829278349876404, "2028": 0.16359257698059082, "2029": 0.20977331697940826, "2033": 0.31560876965522766, "2058": 0.40806588530540466, "2071": 0.015504186972975731, "2... | 2356950 | Methyl-CpG binding protein 1 (MBD1) regulates gene expression via a DNA methylation-mediated epigenetic mechanism. We have previously demonstrated that MBD1 deficiency impairs adult neural stem/progenitor cell (aNSC) differentiation and neurogenesis, but the underlying mechanism was unclear. Here, we show that MBD1 reg... | Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. |
{"1011": 0.09672962874174118, "1014": 0.3388410806655884, "1026": 0.10906458646059036, "1049": 0.13243216276168823, "1052": 0.3519764244556427, "1055": 0.176772341132164, "1999": 0.06703783571720123, "2001": 0.09672962874174118, "2004": 0.5784112811088562, "2005": 0.004870930220931768, "2007": 0.3409265875816345, "2015... | 2359152 | High-throughput DNA sequencing significantly contributed to diagnosis and prognostication in patients with myelodysplastic syndromes (MDS). We determined the biological and prognostic significance of genetic aberrations in MDS. In total, 944 patients with various MDS subtypes were screened for known/putative mutations/... | Landscape of genetic lesions in 944 patients with myelodysplastic syndromes |
{"1015": 0.05970508232712746, "1021": 0.176772341132164, "1043": 0.8674615025520325, "1044": 0.9827804565429688, "1052": 0.2561853528022766, "1058": 0.5244048833847046, "2002": 0.2822965085506439, "2011": 0.05694137513637543, "2020": 0.01934296265244484, "2029": 0.026976587250828743, "2053": 0.151916041970253, "2089": ... | 2360905 | PURPOSE To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). PATIENTS AND METHODS We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGGs, including seven diffuse intrinsic pontine gliomas, and 10 HGGs arising in children who r... | Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease. |
{"1011": 0.1685553640127182, "1043": 0.890972912311554, "2003": 0.2089812457561493, "2005": 0.004870930220931768, "2008": 0.0019512200960889459, "2028": 0.1401015669107437, "2029": 0.022212404757738113, "2046": 0.1401015669107437, "2050": 0.8583967685699463, "2063": 0.5618454217910767, "2109": 0.3163207769393921, "2129... | 2374637 | Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe a powerful analytical method called Gene Set Enrichment Analysis (GSEA) for interpreting gene expression data. The method derives... | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. |
{"1011": 0.2719337046146393, "1997": 0.058784693479537964, "1998": 0.4311734735965729, "2004": 0.3134697377681732, "2007": 0.1212492436170578, "2013": 0.3930181860923767, "2015": 0.48610860109329224, "2031": 0.129004567861557, "2038": 0.20022670924663544, "2042": 0.2531573474407196, "2048": 0.22937409579753876, "2057":... | 2380002 | Increasing numbers of transcripts have been reported to transmit both protein-coding and regulatory information. Apart from challenging our conception of the gene, this observation raises the question as to what extent this phenomenon occurs across the genome and how and why such dual encoding of function has evolved i... | The evolution of RNAs with multiple functions. |
{"1009": 0.672426164150238, "1011": 0.27342069149017334, "1018": 0.39367714524269104, "1039": 0.18978065252304077, "1056": 0.9724938273429871, "2000": 0.1477125883102417, "2005": 0.2749055027961731, "2013": 0.18573370575904846, "2019": 0.46363574266433716, "2024": 0.03831886500120163, "2029": 0.23556606471538544, "2044... | 2388819 | The low number of CD4+ CD25+ regulatory T cells (Tregs), their anergic phenotype, and diverse antigen specificity present major challenges to harnessing this potent tolerogenic population to treat autoimmunity and transplant rejection. In this study, we describe a robust method to expand antigen-specific Tregs from aut... | In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes |
{"1003": 0.04113444685935974, "1017": 0.18167030811309814, "1044": 0.3170322775840759, "1048": 0.6038249135017395, "1050": 0.5267143249511719, "1052": 0.07341018319129944, "2004": 0.28597161173820496, "2005": 0.018384648486971855, "2006": 0.678390383720398, "2007": 0.02316705882549286, "2010": 0.6165571808815002, "2019... | 2389574 | PURPOSE Overexpression of the oncogen Stathmin has been linked to aggressive endometrial carcinoma and a potential for PI3Kinase inhibitors in this disease. We wanted to validate the prognostic value of Stathmin expression in a large prospective multicenter setting. As lymph node sampling is part of current surgical st... | Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer. |
{"1013": 0.07612881064414978, "1014": 0.2689530849456787, "1017": 0.06886265426874161, "1020": 0.23633737862110138, "1022": 0.18004031479358673, "1023": 0.09761575609445572, "1039": 0.2852376699447632, "1052": 0.23556606471538544, "1054": 0.08513788133859634, "1059": 0.5528968572616577, "2005": 0.0058422754518687725, "... | 2391552 | INTRODUCTION Induction of an inflammatory response is thought to have a significant role in the complications that follow cardiopulmonary bypass (CPB). The statin drugs are increasingly being recognized as having potent anti-inflammatory effects and hence have potential to influence an important mechanism of injury in ... | Statin prophylaxis and inflammatory mediators following cardiopulmonary bypass: a systematic review |
{"1011": 0.09938567131757736, "1015": 0.029824240133166313, "1020": 0.4938860833644867, "1022": 0.43812891840934753, "1023": 0.37371641397476196, "1039": 0.9878844022750854, "1041": 0.6980181336402893, "1042": 0.5284429788589478, "1052": 0.371698260307312, "1056": 0.5381823778152466, "2001": 0.021256839856505394, "2007... | 2402323 | Genome-wide copy number profiles were characterized in 41 primary bladder tumors using array-based comparative genomic hybridization (array CGH). In addition to previously identified alterations in large chromosomal regions, alterations were identified in many small genomic regions, some with high-level amplifications ... | Array-based Comparative Genomic Hybridization for Genome-Wide Screening of DNA Copy Number in Bladder Tumors |
{"1019": 0.3883931338787079, "1020": 0.7610978484153748, "1999": 0.0174254160374403, "2005": 0.08871890604496002, "2010": 0.7898768186569214, "2011": 0.35813871026039124, "2012": 0.03360854089260101, "2020": 0.006812678650021553, "2026": 0.5936289429664612, "2029": 0.04860413447022438, "2033": 0.4228905141353607, "2039... | 2405259 | Epigenetic modifiers have fundamental roles in defining unique cellular identity through the establishment and maintenance of lineage-specific chromatin and methylation status. Several DNA modifications such as 5-hydroxymethylcytosine (5hmC) are catalysed by the ten eleven translocation (Tet) methylcytosine dioxygenase... | Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6 |
{"1011": 0.23402166366577148, "1022": 0.0770333781838417, "1042": 0.18411032855510712, "1051": 0.0842406153678894, "1056": 0.7809720039367676, "1998": 0.05694137513637543, "2005": 0.3177432417869568, "2007": 0.5186077356338501, "2008": 0.1229778528213501, "2029": 0.472198486328125, "2064": 0.1946154683828354, "2079": 0... | 2417551 | TNFR/TNF superfamily members can control diverse aspects of immune function. Research over the past 10 years has shown that one of the most important and prominent interactions in this family is that between OX40 (CD134) and its partner OX40L (CD252). These molecules strongly regulate conventional CD4 and CD8 T cells, ... | Control of immunity by the TNFR-related molecule OX40 (CD134). |
{"1011": 0.0842406153678894, "1015": 0.26446542143821716, "1020": 0.1384023278951645, "1023": 0.08871890604496002, "1996": 0.2247048318386078, "2003": 0.20421554148197174, "2004": 0.010684899985790253, "2005": 0.319873183965683, "2008": 0.14518201351165771, "2011": 0.11865071207284927, "2029": 0.25845035910606384, "203... | 2423940 | Cholesterol homeostasis is required to maintain normal cellular function and avoid the deleterious effects of hypercholesterolemia. Here we show that the Drosophila DHR96 nuclear receptor binds cholesterol and is required for the coordinate transcriptional response of genes that are regulated by cholesterol and involve... | The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis. |
{"1023": 0.3963087201118469, "1044": 0.1710275560617447, "1998": 0.053244512528181076, "2007": 0.04767346754670143, "2029": 0.02412080205976963, "2058": 0.1685553640127182, "2084": 0.1734936386346817, "2089": 0.0354953333735466, "2090": 0.3464667797088623, "2106": 0.06246116757392883, "2152": 0.4002431631088257, "2179"... | 2424794 | Because children are becoming overweight, unhealthy, and unfit, understanding the neurocognitive benefits of an active lifestyle in childhood has important public health and educational implications. Animal research has indicated that aerobic exercise is related to increased cell proliferation and survival in the hippo... | A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. |
{"1040": 1.1063944101333618, "1044": 0.37102460861206055, "1051": 0.39762192964553833, "2002": 0.045809537172317505, "2011": 0.38441169261932373, "2021": 0.06246116757392883, "2025": 0.18248429894447327, "2029": 0.07431721687316895, "2043": 0.04860413447022438, "2076": 0.48068851232528687, "2077": 0.1946154683828354, "... | 2425364 | OBJECTIVE To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth variables. DESIGN Systematic review and meta-analysis. DATA SOURCES Medline (1966 to August 2012), PubMed (2008 to August 2012), Embase (1980 to August 2012), CINAHL (1981 to August 2012), the Cochrane database of syst... | Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. |
{"1009": 0.1905880719423294, "1011": 0.16359257698059082, "1020": 0.22626367211341858, "1039": 0.7124901413917542, "1042": 0.8877626657485962, "1043": 0.5057345628738403, "1048": 0.26146242022514343, "1056": 0.151916041970253, "1155": 0.20739519596099854, "1156": 0.5433003902435303, "2011": 0.10379679501056671, "2020":... | 2436602 | Psychosocial stress is associated with altered immune function and development of psychological disorders including anxiety and depression. Here we show that repeated social defeat in mice increased c-Fos staining in brain regions associated with fear and threat appraisal and promoted anxiety-like behavior in a β-adren... | β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. |
{"1011": 0.22782009840011597, "1016": 0.1873544454574585, "1041": 0.6734226942062378, "1042": 0.861702561378479, "2004": 0.02412080205976963, "2005": 0.1332872211933136, "2011": 0.29981520771980286, "2013": 0.4734157919883728, "2015": 0.22001366317272186, "2020": 0.21372433006763458, "2029": 0.09938567131757736, "2044"... | 2437807 | The remarkable developmental potential and replicative capacity of human embryonic stem (ES) cells promise an almost unlimited supply of specific cell types for transplantation therapies. Here we describe the in vitro differentiation, enrichment, and transplantation of neural precursor cells from human ES cells. Upon a... | In vitro differentiation of transplantable neural precursors from human embryonic stem cells |
{"1011": 0.08154398202896118, "1016": 0.10379679501056671, "1039": 0.637939989566803, "1041": 0.5751199722290039, "1048": 0.29981520771980286, "1052": 0.0317181795835495, "1999": 0.15860503911972046, "2008": 0.11865071207284927, "2011": 0.44753631949424744, "2012": 0.36290550231933594, "2013": 0.2976420819759369, "2029... | 2443495 | Candida albicans produces lipid metabolites that are functionally similar to host prostaglandins. These studies, using mass spectrometry, demonstrate that C. albicans produces authentic prostaglandin E(2) (PGE(2)) from arachidonic acid. Maximal PGE(2) production was achieved at 37 degrees C in stationary-phase culture ... | Characterization of prostaglandin E2 production by Candida albicans. |
{"1011": 0.26146242022514343, "1015": 0.36967599391937256, "1041": 0.3757305145263672, "1043": 0.3381449282169342, "1044": 0.4512746334075928, "1047": 1.1051015853881836, "1999": 0.06337817758321762, "2005": 0.07612881064414978, "2007": 0.11517547070980072, "2008": 0.0317181795835495, "2011": 0.304147332906723, "2012":... | 2452989 | KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent progenitors. To determine the local cis-regulatory contexts and transcription factor networks in which KLF1 operates, we performed KLF1 ChIP-seq in the mouse. We found at least 945 sites in the genome of E14.5 fetal liver ery... | A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. |
{"1012": 0.14602625370025635, "1014": 0.848413348197937, "1016": 0.5010119676589966, "1019": 0.0797421783208847, "1043": 0.22859740257263184, "1047": 0.5517725944519043, "1052": 0.2763880789279938, "2003": 0.2026219218969345, "2008": 0.08782484382390976, "2013": 0.17922431230545044, "2064": 0.3750596046447754, "2072": ... | 2454002 | High-throughput experimental technologies often identify dozens to hundreds of genes related to, or changed in, a biological or pathological process. From these genes one wants to identify biological pathways that may be involved and diseases that may be implicated. Here, we report a web server, KOBAS 2.0, which annota... | KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases |
{"1011": 0.1332872211933136, "1021": 0.5849615335464478, "1040": 0.2749055027961731, "1044": 0.8893690705299377, "1052": 0.2561853528022766, "1999": 0.06886265426874161, "2002": 0.28597161173820496, "2008": 0.12728634476661682, "2011": 0.3070250153541565, "2012": 0.2539152204990387, "2015": 0.13670019805431366, "2020":... | 2460304 | Erythrocytes carrying a variant hemoglobin allele (HbS), which causes sickle cell disease and resists infection by the malaria parasite Plasmodium falciparum. The molecular basis of this resistance, which has long been recognized as multifactorial, remains incompletely understood. Here we show that the dysregulated mic... | Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. |
{"1011": 0.23247487843036652, "1015": 0.3662964701652527, "1018": 0.5871354341506958, "1039": 0.0058422754518687725, "1048": 0.5324648022651672, "1056": 1.0788878202438354, "1999": 0.151916041970253, "2009": 1.1665629148483276, "2011": 0.1930064558982849, "2029": 0.052318159490823746, "2037": 0.03831886500120163, "2046... | 2462673 | Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the co-inhibitory receptor cytotoxic T lymphocyte antigen-4 (CTLA-4) develop fatal autoimmunity characterized by lymphocytic infiltration into nonlymphoid tissues. Here, we demonstrate that th... | CD28 and ITK signals regulate autoreactive T cell trafficking |
{"1018": 0.040196798741817474, "1998": 0.015504186972975731, "2007": 0.06246116757392883, "2015": 0.030771657824516296, "2029": 0.006812678650021553, "2037": 0.0797421783208847, "2048": 0.12470348179340363, "2058": 0.5215105414390564, "2079": 0.0770333781838417, "2089": 0.08782484382390976, "2090": 0.13414156436920166,... | 2466614 | Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between the genome-wide liver expression ... | Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms |
{"1015": 0.045809537172317505, "1020": 0.24018502235412598, "1038": 0.2763880789279938, "1039": 0.04674193635582924, "1045": 0.5398913025856018, "1050": 0.5045560002326965, "1056": 0.9115922451019287, "1996": 0.030771657824516296, "1999": 0.14518201351165771, "2008": 0.05139094591140747, "2011": 0.2786078155040741, "20... | 2474731 | The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model. We found that both the endothelium and epithelium of murine corn... | Arginine depletion as a mechanism for the immune privilege of corneal allografts |
{"1008": 0.07159364968538284, "1019": 0.2247048318386078, "1040": 0.14349138736724854, "1053": 0.8323994874954224, "2001": 0.11256109178066254, "2003": 0.25239890813827515, "2005": 0.4537591338157654, "2020": 0.03831886500120163, "2033": 0.3012613356113434, "2038": 0.0019512200960889459, "2044": 0.35745587944984436, "2... | 2475059 | OBJECTIVE Methylphenidate (MPH), the most commonly prescribed drug for attention-deficit/hyperactivity disorder (ADHD), has a short half-life, which necessitates multiple daily doses. The need for multiple doses produces problems with medication administration during school and after-school hours, and therefore with co... | Once-a-day Concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings. |
{"1005": 0.007782140281051397, "1011": 0.27786844968795776, "1019": 0.5290185213088989, "1999": 0.04113444685935974, "2012": 0.33325836062431335, "2013": 0.2493593990802765, "2015": 0.0317181795835495, "2025": 0.058784693479537964, "2029": 0.02887592278420925, "2037": 0.05694137513637543, "2042": 0.22079704701900482, "... | 2479538 | BACKGROUND Shine-Dalgarno (SD) signal has long been viewed as the dominant translation initiation signal in prokaryotes. Recently, leaderless genes, which lack 5'-untranslated regions (5'-UTR) on their mRNAs, have been shown abundant in archaea. However, current large-scale in silico analyses on initiation mechanisms i... | Leaderless genes in bacteria: clue to the evolution of translation initiation mechanisms in prokaryotes |
{"1009": 0.5822374224662781, "1011": 0.04767346754670143, "1015": 0.5795059204101562, "1042": 0.30917787551879883, "1044": 0.17840765416622162, "1056": 0.1477125883102417, "2003": 0.3949938118457794, "2004": 0.09495500475168228, "2007": 0.18816383183002472, "2008": 0.13499516248703003, "2011": 0.259204238653183, "2028"... | 2481032 | Sirt1 is a NAD(+)-dependent class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neuronal Sirt1 activity plays a role in the central regulation of energy balance and glucose metabolism. To assess this idea,... | Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. |
{"1011": 0.08513788133859634, "1040": 0.015504186972975731, "1041": 0.8829278349876404, "1043": 0.997294545173645, "1053": 0.1693800985813141, "1054": 0.6659244894981384, "1055": 0.6107416749000549, "2007": 0.32553088665008545, "2011": 0.1401015669107437, "2015": 0.23015019297599792, "2029": 0.10026945173740387, "2041"... | 2485101 | The recent success of genome-wide association studies (GWAS) is now followed by the challenge to determine how the reported susceptibility variants mediate complex traits and diseases. Expression quantitative trait loci (eQTLs) have been implicated in disease associations through overlaps between eQTLs and GWAS signals... | Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations |
{"1003": 0.0019512200960889459, "1016": 0.05970508232712746, "1021": 0.11778303235769272, "1052": 0.347847044467926, "2001": 0.05046287178993225, "2002": 0.015504186972975731, "2004": 0.0058422754518687725, "2011": 0.07341018319129944, "2035": 0.5104349255561829, "2043": 0.14264501631259918, "2044": 0.6553317308425903,... | 2488880 | CONTEXT While it is established that management strategies and outcomes differ by gender for many diseases, its effect on infection has not been adequately studied. OBJECTIVE To investigate the role of gender among hospitalized patients treated for infection. DESIGN Observational cohort study conducted during a 26-mont... | Gender-dependent differences in outcome after the treatment of infection in hospitalized patients. |
{"1609": 0.3339579105377197, "2001": 0.020300358533859253, "2004": 0.46608972549438477, "2005": 0.25239890813827515, "2007": 0.12642613053321838, "2015": 0.08782484382390976, "2020": 0.10906458646059036, "2022": 0.736154317855835, "2029": 0.06337817758321762, "2035": 0.2749055027961731, "2044": 0.04487626627087593, "20... | 2492146 | Metastatic colorectal cancer (mCRC) is increasingly treated using targeted therapies. Post-marketing safety of these agents is understudied, especially in the elderly. This study aimed to compare, according to age, the adverse drug reactions (ADRs) of targeted therapies used for mCRC in real life. An extraction of Vigi... | Comparative Safety of Targeted Therapies for Metastatic Colorectal Cancer between Elderly and Younger Patients: a Study Using the International Pharmacovigilance Database |
{"1011": 0.07612881064414978, "1014": 0.4487839937210083, "1015": 0.14349138736724854, "1017": 0.03266380727291107, "1020": 0.0009760859538801014, "1026": 0.09672962874174118, "1052": 0.674915611743927, "2012": 0.09850110858678818, "2029": 0.21372433006763458, "2033": 0.07068414986133575, "2050": 0.0058422754518687725,... | 2494748 | There are limited reports on methylation analysis of the premalignant lesions of gastric carcinoma thus far. This is despite the fact that gastric carcinoma is one of the tumors with a high frequency of CpG island hypermethylation. To determine the frequency and timing of hypermethylation during multistep gastric carci... | CpG island methylation in premalignant stages of gastric carcinoma. |
{"1011": 0.3723714053630829, "1042": 0.5381823778152466, "1044": 0.16276304423809052, "1054": 0.012615402229130268, "1056": 0.7601850032806396, "2003": 0.2719337046146393, "2011": 0.06337817758321762, "2019": 0.21214580535888672, "2086": 0.04113444685935974, "2087": 0.12986256182193756, "2099": 1.1971133947372437, "214... | 2496002 | Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a fatal clinical disorder characterized by extracellular deposition of abnormal fibrils derived from misfolded, normally soluble transthyretin (TTR) molecules. The disease is most commonly caused by a point mutation within the TTR gene inherited in an autosomal... | Familial amyloidotic polyneuropathy: current and emerging treatment options for transthyretin-mediated amyloidosis |
{"1043": 0.37304413318634033, "1048": 0.29109421372413635, "1056": 0.9271688461303711, "2007": 0.2539152204990387, "2011": 0.27564704418182373, "2024": 0.09672962874174118, "2031": 0.026976587250828743, "2061": 0.7436100244522095, "2064": 0.29109421372413635, "2066": 0.3750596046447754, "2079": 0.35745587944984436, "20... | 2506153 | Cells of the innate immune system interact with pathogens via conserved pattern-recognition receptors, whereas cells of the adaptive immune system recognize pathogens through diverse, antigen-specific receptors that are generated by somatic DNA rearrangement. Invariant natural killer T (iNKT) cells are a subset of lymp... | Invariant natural killer T cells: bridging innate and adaptive immunity |
{"1011": 0.18167030811309814, "1044": 0.6764062643051147, "1054": 0.3191637098789215, "1998": 0.07612881064414978, "2000": 0.16690383851528168, "2003": 0.1229778528213501, "2005": 0.5209306478500366, "2007": 0.5551415085792542, "2024": 0.014542185701429844, "2029": 0.10555581003427505, "2034": 0.5936289429664612, "2038... | 2522977 | The main purpose in hypertension treatment is the reduction of cardiovascular disease burden. Among different first-line antihypertensive drug classes, angiotensin-receptor blockers are characterized by their both good effectiveness and tolerability. Furthermore, the interruption of the renin-angiotensin cascade is rel... | Olmesartan-based therapies: an effective way to improve blood pressure control and cardiovascular protection. |
{"1042": 0.22782009840011597, "1052": 0.13071982562541962, "1999": 0.0317181795835495, "2003": 0.2749055027961731, "2005": 0.44753631949424744, "2008": 0.11081436276435852, "2019": 0.05786345899105072, "2024": 0.35677260160446167, "2029": 0.08513788133859634, "2042": 0.11517547070980072, "2043": 0.24631060659885406, "2... | 2526777 | Falciparum malaria kills, and it particularly kills the rural poor. Artemisinin derivatives, such as artesunate, are a vital component of Plasmodium falciparum malaria treatment and control in the face of globally increasing antimalarial drug resistance. Since 1998 a worsening epidemic of sophisticated counterfeit “art... | Manslaughter by Fake Artesunate in Asia—Will Africa Be Next? |
{"1015": 0.2317005842924118, "1040": 0.40546512603759766, "1041": 0.35745587944984436, "1043": 0.3325583338737488, "1050": 0.06703783571720123, "1051": 0.009718249551951885, "2076": 0.020300358533859253, "2080": 0.08513788133859634, "2089": 0.018384648486971855, "2094": 0.1693800985813141, "2135": 0.4794800877571106, "... | 2533768 | Clinical manifestations of diabetic nephropathy are an expression of diabetic microangiopathy. This review revisits the previously proposed Steno hypothesis and advances our hypothesis that development of endothelial cell dysfunction represents a common pathophysiological pathway of diabetic complications. Specifically... | Workshop: endothelial cell dysfunction leading to diabetic nephropathy : focus on nitric oxide. |
{"1011": 0.11168810725212097, "1015": 0.2763880789279938, "1017": 0.1994270235300064, "1023": 0.6075552701950073, "1039": 0.23710809648036957, "1044": 0.4462870955467224, "1048": 0.3949938118457794, "2007": 0.03266380727291107, "2010": 0.8264343738555908, "2011": 0.16607704758644104, "2012": 0.12384103983640671, "2013"... | 2541699 | Epigenetic information is frequently erased near the start of each new generation. In some cases, however, epigenetic information can be transmitted from parent to progeny (multigenerational epigenetic inheritance). A particularly notable example of this type of epigenetic inheritance is double-stranded RNA-mediated ge... | A nuclear Argonaute promotes multi-generational epigenetic inheritance and germline immortality |
{"2011": 0.3283478021621704, "2012": 0.6512666940689087, "2015": 0.7934166193008423, "2029": 0.0009760859538801014, "2063": 0.3191637098789215, "2064": 0.28450319170951843, "2071": 0.015504186972975731, "2076": 0.33675122261047363, "2079": 0.3443928062915802, "2090": 0.030771657824516296, "2091": 0.16442140936851501, "... | 2543135 | Autophagy plays a central role in regulating important cellular functions such as cell survival during starvation and control of infectious pathogens. Recently, it has been shown that autophagy can induce cells to die; however, the mechanism of the autophagic cell death program is unclear. We now show that caspase inhi... | Autophagic programmed cell death by selective catalase degradation. |
{"1056": 0.49982786178588867, "2011": 0.0038986403960734606, "2029": 0.10203468054533005, "2037": 0.3283478021621704, "2043": 0.35060185194015503, "2049": 0.02412080205976963, "2051": 0.5086748600006104, "2076": 0.5579402446746826, "2079": 0.32129061222076416, "2089": 0.06429435312747955, "2090": 0.09850110858678818, "... | 2547636 | Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that in human epidermal stem cells and their differentiated counterparts, core clock genes peak in a successive and phased manne... | Human epidermal stem cell function is regulated by circadian oscillations. |
{"1011": 0.31489628553390503, "1038": 0.947819709777832, "1041": 0.1710275560617447, "1050": 0.4818955361843109, "1999": 0.029824240133166313, "2003": 0.02792670577764511, "2005": 0.38308101892471313, "2026": 0.6296497583389282, "2029": 0.1510767638683319, "2044": 0.3656192123889923, "2046": 0.5651806592941284, "2053":... | 2559303 | Cellular cardiomyoplasty is an attractive option for the treatment of severe heart failure. It is, however, still unclear and controversial which is the most promising cell source. Therefore, we investigated and examined the fate and functional impact of bone marrow (BM) cells and embryonic stem cell (ES cell)–derived ... | Engraftment of engineered ES cell–derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium |
{"1040": 0.3248254358768463, "1043": 0.3141832649707794, "1044": 0.4286321699619293, "1052": 0.43875885009765625, "2003": 0.04394211992621422, "2005": 0.23556606471538544, "2007": 0.2954642176628113, "2011": 0.026976587250828743, "2029": 0.13925230503082275, "2050": 1.1994705200195312, "2058": 0.2837681770324707, "2079... | 2565138 | OBJECTIVE Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant extracellular matrix component, the megadalton glycosaminoglycan hyaluronan (HA), as a novel therapeutic target in PDA. ME... | Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer |
{"1011": 0.46853771805763245, "1015": 0.09850110858678818, "1016": 0.8400169610977173, "1019": 0.33325836062431335, "1045": 0.5893046259880066, "1051": 0.8315495252609253, "1531": 0.3743882179260254, "1996": 0.04394211992621422, "1997": 0.22626367211341858, "1999": 0.06246116757392883, "2004": 0.11691460013389587, "200... | 2566674 | The 5′ cap structures of higher eukaryote mRNAs have ribose 2′-O-methylation. Likewise, many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-methyltransferases to autonomously modify their mRNAs. However, a defined biological role for 2′-O-methylation of mRNA remains elusive. Here we show that 2... | Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 |
{"1011": 0.09850110858678818, "1013": 0.2969166338443756, "1014": 0.3248254358768463, "1022": 0.26146242022514343, "1026": 0.0606246218085289, "1052": 0.4002431631088257, "1054": 0.8633513450622559, "1998": 0.28450319170951843, "2043": 0.004870930220931768, "2082": 0.06429435312747955, "2090": 0.4494072198867798, "2099... | 2575938 | The relationships between children's activity, aerobic fitness, and fatness are unclear. Indirect estimates of activity, e.g., heart rate (HR) and recall, may mask any associations. The purpose of this study was to assess these relationships by using the Tritrac-R3D, a pedometer, and heart rate. Thirty-four children, a... | Relationship between activity levels, aerobic fitness, and body fat in 8- to 10-yr-old children. |
{"1011": 0.3656192123889923, "1015": 0.05970508232712746, "1016": 0.17840765416622162, "1042": 0.28963330388069153, "2005": 0.1889725625514984, "2019": 0.07884006202220917, "2029": 0.1602703034877777, "2048": 0.11951763927936554, "2051": 0.14433705806732178, "2066": 0.42608439922332764, "2076": 0.3916989266872406, "207... | 2576811 | Epithelial integrity is vitally important, and its deregulation causes early stage cancer. De novo formation of an adherens junction (AJ) between single epithelial cells requires coordinated, spatial actin dynamics, but the mechanisms steering nascent actin polymerization for cell-cell adhesion initiation are not well ... | Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1 |
{"1011": 0.176772341132164, "1038": 0.5209306478500366, "1048": 0.8525851964950562, "1050": 0.11951763927936554, "1052": 0.6312094330787659, "1996": 0.08244366943836212, "1997": 0.09938567131757736, "1998": 0.083342544734478, "1999": 0.0009760859538801014, "2006": 0.17020416259765625, "2007": 0.7352184057235718, "2008"... | 2582169 | The importance of coordinating cell growth with proliferation has been recognized for a long time. The molecular basis of this relationship, however, is poorly understood. Here we show that the ribosomal protein L23 interacts with HDM2. The interaction involves the central acidic domain of HDM2 and an N-terminal domain... | Inhibition of HDM2 and activation of p53 by ribosomal protein L23. |
{"1011": 0.07884006202220917, "1018": 0.009718249551951885, "1052": 0.450652539730072, "1056": 0.8298473954200745, "1999": 0.10467668622732162, "2003": 0.20580662786960602, "2007": 0.06520967930555344, "2011": 0.1212492436170578, "2012": 0.8143964409828186, "2013": 0.08603433519601822, "2026": 0.6892333030700684, "2029... | 2587396 | Background: Atherosclerosis is characterized by infiltration of inflammatory cells from circulating blood. Blood cell activation could play an important role in plaque formation. Methods: We analyzed the relationship between blood cellular markers and quantitative measures of carotid wall components in 1,546 participan... | Association of Blood Monocyte and Platelet Markers with Carotid Artery Characteristics: The Atherosclerosis Risk in Communities Carotid MRI Study |
{"1016": 0.15442965924739838, "1039": 0.28963330388069153, "1041": 0.02316705882549286, "1052": 0.43812891840934753, "1058": 0.47463157773017883, "1157": 0.39893341064453125, "2003": 0.2478361576795578, "2007": 0.07612881064414978, "2011": 0.23479416966438293, "2012": 0.21765978634357452, "2029": 0.14349138736724854, "... | 2593298 | Receptor endocytosis is a fundamental step in controlling the magnitude, duration, and nature of cell signaling events. Confluent endothelial cells are contact inhibited in their growth and respond poorly to the proliferative signals of vascular endothelial growth factor (VEGF). In a previous study, we found that the a... | Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments |
{"1011": 0.2711893916130066, "1013": 0.4228905141353607, "1015": 0.5415972471237183, "1021": 0.05417001247406006, "1039": 0.7647408246994019, "1042": 0.6322478652000427, "1043": 0.6011518239974976, "1044": 0.5110208988189697, "1050": 0.7389566898345947, "1056": 0.6902132034301758, "1058": 0.20022670924663544, "1997": 0... | 2601135 | A recent study of plasma neutralization breadth in HIV-1 infected individuals at nine International AIDS Vaccine Initiative (IAVI) sites reported that viral load, HLA-A*03 genotype, and subtype C infection were strongly associated with the development of neutralization breadth. Here, we refine the findings of that stud... | Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth |
{"1011": 0.27564704418182373, "1039": 0.6223390698432922, "1043": 0.9485763907432556, "1996": 0.05417001247406006, "2003": 0.0913962796330452, "2011": 0.1930064558982849, "2012": 0.12814582884311676, "2020": 0.0058422754518687725, "2024": 0.29473719000816345, "2026": 0.9256220459938049, "2029": 0.1946154683828354, "203... | 2601324 | Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity. However, the underlying support mechanisms are not understood. Here we identify a metabolic component of axon–glia interactions by generating conditional Cox10 (protoheme IX farnesyltransferase) mutant m... | Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity |
{"1009": 0.5415972471237183, "1011": 0.43244171142578125, "1015": 0.7229714393615723, "1018": 0.00875066313892603, "1039": 0.7898768186569214, "1040": 0.35745587944984436, "1043": 0.23092569410800934, "1045": 0.37640097737312317, "1056": 0.6548244953155518, "1999": 0.018384648486971855, "2003": 0.08513788133859634, "20... | 2603304 | Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cells. Uninfected DCs capture HIV-1 and mediate viral transfer to bystander CD4(+) T cells through a process termed trans-infection. In... | Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides |
{"1043": 0.07250232994556427, "1996": 0.015504186972975731, "1999": 0.3353555500507355, "2013": 0.09850110858678818, "2034": 0.5186077356338501, "2038": 0.176772341132164, "2042": 0.10379679501056671, "2043": 0.24401791393756866, "2052": 0.26296505331993103, "2064": 0.1930064558982849, "2066": 0.272677481174469, "2071"... | 2604063 | The intestinal microbiota has become a relevant aspect of human health. Microbial colonization runs in parallel with immune system maturation and plays a role in intestinal physiology and regulation. Increasing evidence on early microbial contact suggest that human intestinal microbiota is seeded before birth. Maternal... | The composition of the gut microbiota throughout life, with an emphasis on early life |
{"1003": 0.151916041970253, "1018": 0.10731173306703568, "1020": 0.347847044467926, "1998": 0.07612881064414978, "1999": 0.05970508232712746, "2007": 0.17020416259765625, "2011": 0.06337817758321762, "2020": 0.08603433519601822, "2044": 0.5450005531311035, "2046": 0.39433568716049194, "2052": 0.1718502640724182, "2057"... | 2605032 | We investigated if whether intrauterine protein restriction in combination with overfeeding during lactation would cause adult-onset obesity and metabolic disorders. After birth, litters from dams fed with control (17% protein) and low protein (6% protein) diets were adjusted to a size of four (CO and LO groups, respec... | Intrauterine protein restriction combined with early postnatal overfeeding was not associated with adult-onset obesity but produced glucose intolerance by pancreatic dysfunction |
{"1019": 0.040196798741817474, "2012": 0.1602703034877777, "2028": 0.055094651877880096, "2043": 0.026976587250828743, "2044": 0.3304552733898163, "2046": 0.4891071021556854, "2064": 0.4974553883075714, "2067": 0.176772341132164, "2070": 0.14433705806732178, "2071": 0.037378571927547455, "2075": 0.10906458646059036, "2... | 2608447 | Defined transcription factors can induce epigenetic reprogramming of adult mammalian cells into induced pluripotent stem cells. Although DNA factors are integrated during some reprogramming methods, it is unknown whether the genome remains unchanged at the single nucleotide level. Here we show that 22 human induced plu... | Somatic coding mutations in human induced pluripotent stem cells |
{"1015": 0.16359257698059082, "1039": 0.5313173532485962, "1047": 0.4330752193927765, "2005": 0.29981520771980286, "2008": 0.08244366943836212, "2011": 0.1358480453491211, "2029": 0.13243216276168823, "2069": 0.4926934838294983, "2076": 0.28155985474586487, "2079": 0.2145126610994339, "2084": 0.034552380442619324, "210... | 2613411 | Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, mammalian CDKs are essential for driving each cell cycle phase, so therapeutic... | Cell cycle, CDKs and cancer: a changing paradigm |
{"2000": 0.01934296265244484, "2012": 0.15359249711036682, "2015": 0.8400169610977173, "2028": 0.004870930220931768, "2043": 0.13499516248703003, "2051": 0.11604541540145874, "2058": 0.4837033152580261, "2060": 0.0752234235405922, "2076": 0.19862671196460724, "2086": 0.07341018319129944, "2087": 0.15275461971759796, "2... | 2613775 | Despite declines in prevalence during the past two decades, sudden infant death syndrome (SIDS) continues to be the leading cause of death for infants aged between 1 month and 1 year in developed countries. Behavioural risk factors identified in epidemiological studies include prone and side positions for infant sleep,... | Sudden infant death syndrome. |
{"1011": 0.08692999184131622, "1023": 0.013579257763922215, "1044": 0.05970508232712746, "1048": 0.0009760859538801014, "1997": 0.08782484382390976, "2002": 0.1946154683828354, "2003": 0.20102575421333313, "2008": 0.026976587250828743, "2010": 0.9485763907432556, "2011": 0.20739519596099854, "2029": 0.23092569410800934... | 2613813 | Eukaryotic heterochromatin is characterized by a high density of repeats and transposons, as well as by modified histones, and influences both gene expression and chromosome segregation. In the fission yeast Schizosaccharomyces pombe, we deleted the argonaute, dicer, and RNA-dependent RNA polymerase gene homologs, whic... | Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. |
{"1011": 0.1994270235300064, "1056": 0.6573580503463745, "1155": 0.3134697377681732, "1156": 0.5920094847679138, "1997": 0.1384023278951645, "2002": 0.48670899868011475, "2003": 0.015504186972975731, "2011": 0.10467668622732162, "2029": 0.16524957120418549, "2033": 0.3177432417869568, "2046": 0.2470736801624298, "2048"... | 2617858 | Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transitions that remain to be structurally and mechanistically characterised. ... | Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin |
{"1011": 0.1384023278951645, "1996": 0.00875066313892603, "2003": 0.2837681770324707, "2008": 0.1619328260421753, "2011": 0.16110190749168396, "2015": 0.39367714524269104, "2024": 0.46608972549438477, "2029": 0.08782484382390976, "2050": 0.12384103983640671, "2054": 0.0752234235405922, "2078": 0.5718178153038025, "2079... | 2619579 | MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are ∼21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified major factors participating in miRNA biogenesis and has established... | The widespread regulation of microRNA biogenesis, function and decay |
{"1011": 0.058784693479537964, "1015": 0.24248650670051575, "1038": 0.6522845029830933, "1039": 0.12814582884311676, "1043": 0.5629584193229675, "1044": 0.24401791393756866, "1999": 0.09672962874174118, "2005": 0.029824240133166313, "2011": 0.09495500475168228, "2029": 0.05046287178993225, "2036": 0.306306391954422, "2... | 2638387 | High mutation frequency during reverse transcription has a principal role in the genetic variation of primate lentiviral populations. It is the main driving force for the generation of drug resistance and the escape from immune surveillance. G to A hypermutation is one of the characteristics of primate lentiviruses, as... | The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA |
{"1011": 0.07431721687316895, "1014": 0.32764431834220886, "1020": 0.20102575421333313, "1039": 0.3416208028793335, "1043": 0.5607312321662903, "1052": 0.6075552701950073, "1055": 0.49030399322509766, "1056": 0.9987343549728394, "1155": 0.4132472574710846, "2011": 0.04860413447022438, "2020": 0.09495500475168228, "2029... | 2647374 | INTRODUCTION Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis. Toll-like receptor (TLR) signaling pathways and their negative regulators play a pivotal role in the modulation of host immune responses and the development of sepsis. The objective of this study was to investigate the... | Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population |
{"1017": 0.1913948506116867, "1018": 0.11081436276435852, "1050": 0.2160874605178833, "2000": 0.19622190296649933, "2001": 0.083342544734478, "2020": 0.04394211992621422, "2022": 0.05417001247406006, "2043": 0.18816383183002472, "2050": 0.11168810725212097, "2052": 0.2659635543823242, "2058": 0.2089812457561493, "2064"... | 2659805 | A number of methods have been developed to assist subjects in providing an estimate of portion size but their application in improving portion size estimation by children has not been investigated systematically. The aim was to develop portion size assessment tools for use with children and to assess the accuracy of ch... | Children's estimates of food portion size: the development and evaluation of three portion size assessment tools for use with children. |
{"1011": 0.07159364968538284, "1018": 0.04674193635582924, "1039": 0.22157983481884003, "1050": 0.650757372379303, "1060": 0.40806588530540466, "1996": 0.22937409579753876, "1997": 0.1930064558982849, "2012": 0.24018502235412598, "2029": 0.1221139207482338, "2048": 0.15526613593101501, "2063": 0.8039615154266357, "2073... | 2665425 | The budding yeast kinetochore is ~68 nm in length with a diameter slightly larger than a 25 nm microtubule. The kinetochores from the 16 chromosomes are organized in a stereotypic cluster encircling central spindle microtubules. Quantitative analysis of the inner kinetochore cluster (Cse4, COMA) reveals structural feat... | A 3D Map of the Yeast Kinetochore Reveals the Presence of Core and Accessory Centromere-Specific Histone |
{"1037": 0.22392450273036957, "2000": 0.0058422754518687725, "2003": 0.06337817758321762, "2004": 1.0116009712219238, "2006": 1.0464962720870972, "2015": 0.27044451236724854, "2022": 0.14518201351165771, "2031": 0.10379679501056671, "2040": 0.083342544734478, "2054": 0.23247487843036652, "2055": 0.16276304423809052, "2... | 2665675 | Oncologists have a critical opportunity to utilize risk assessment and cancer prevention strategies to interrupt the initiation or progression of cancer in cancer survivors and individuals at high risk of developing cancer. Expanding knowledge about the natural history and prognosis of cancers positions oncologists to ... | American Society of Clinical Oncology policy statement: the role of the oncologist in cancer prevention and risk assessment. |
{"1005": 0.040196798741817474, "1011": 0.05046287178993225, "1038": 0.8450632095336914, "1043": 0.14602625370025635, "1048": 0.4673144817352295, "1055": 0.5197699069976807, "1057": 0.40806588530540466, "1059": 1.1994705200195312, "1998": 0.0174254160374403, "2002": 0.7172679901123047, "2003": 0.04674193635582924, "2004... | 2679511 | Werner's syndrome (WS) and Bloom's syndrome (BS) are cancer predisposition disorders caused by loss of function of the RecQ helicases WRN or BLM, respectively. BS and WS are characterized by replication defects, hyperrecombination events and chromosomal aberrations, which are hallmarks of cancer. Inefficient replicatio... | The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures |
{"1017": 0.1212492436170578, "1041": 0.5947071313858032, "2005": 0.029824240133166313, "2011": 0.2145126610994339, "2013": 0.5629584193229675, "2015": 0.8074519634246826, "2029": 0.0317181795835495, "2046": 0.6487176418304443, "2050": 0.35745587944984436, "2064": 0.17759032547473907, "2081": 0.32058215141296387, "2089"... | 2682251 | Various conditions for differentiating embryonic stem (ES) cells or induced pluripotent stem (iPS) cells into specific kinds of cell lines are under intensive investigation. However, the production of a functional organ with a three-dimensional structure from ES or iPS cells is difficult to achieve in vitro. In the pre... | Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras. |
{"1011": 0.25995752215385437, "1013": 0.30917787551879883, "1018": 0.034552380442619324, "1021": 0.06246116757392883, "1043": 0.3750596046447754, "1059": 1.1375575065612793, "1156": 0.20501139760017395, "1998": 0.08603433519601822, "2008": 0.03360854089260101, "2011": 0.11430477350950241, "2015": 0.36900100111961365, "... | 2682997 | Despite the importance of CNS blood vessels, the molecular mechanisms that regulate CNS angiogenesis and blood-brain barrier (BBB) formation are largely unknown. Here we analyze the role of Wnt/beta-catenin signaling in regulating the formation of CNS blood vessels. First, through the analysis of TOP-Gal Wnt reporter m... | Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. |
{"1011": 0.1889725625514984, "1017": 0.4400174915790558, "1044": 0.15943801403045654, "1046": 0.3897167444229126, "1048": 0.4764525294303894, "1052": 0.3956514894962311, "1060": 0.5662899017333984, "1999": 0.21372433006763458, "2003": 0.34922540187835693, "2005": 0.26820653676986694, "2011": 0.24018502235412598, "2013"... | 2686003 | Anthocyanins are a group of naturally occurring phenolic compounds widely available in fruits and vegetables in human diets. They have broad biological activities including anti-mutagenesis and anticarcinogenesis, which are generally attributed to their antioxidant activities. We studied the effects and the mechanisms ... | Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. |
{"1011": 0.07884006202220917, "1015": 0.16359257698059082, "1052": 0.36697331070899963, "1998": 0.016465263441205025, "1999": 0.35334911942481995, "2004": 0.7809720039367676, "2013": 0.05786345899105072, "2029": 0.16690383851528168, "2034": 0.34508460760116577, "2036": 0.23247487843036652, "2063": 0.0029254043474793434... | 2692522 | Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tissues. Although MSU crystals were first identified as the aetiological age... | Gout-associated uric acid crystals activate the NALP3 inflammasome |
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