spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1014": 0.2983669638633728, "1040": 0.6054253578186035, "1049": 0.22626367211341858, "1051": 0.01934296265244484, "1052": 0.10818854719400406, "1054": 0.012615402229130268, "2007": 0.12642613053321838, "2025": 0.03925827145576477, "2045": 0.15023678541183472, "2072": 0.23324857652187347, "2090": 0.40806588530540466, "... | 21502234 | BACKGROUND The association between the deficiency in mismatch repair (MMR) genes and prognosis in women with endometrial cancer is unclear. Here we report a systematic review and meta-analysis exploring this association. METHODS We searched literature databases (MEDLINE, EMBASE, and Cochrane) from 1980 until December 2... | Mismatch repair status and clinical outcome in endometrial cancer: a systematic review and meta-analysis. |
{"1011": 0.06703783571720123, "1015": 0.49923527240753174, "1048": 0.6989894509315491, "1052": 0.981317400932312, "2003": 0.14433705806732178, "2006": 0.5751199722290039, "2008": 0.09228714555501938, "2011": 0.2561853528022766, "2012": 0.27342069149017334, "2028": 0.2317005842924118, "2029": 0.2637155055999756, "2033":... | 21521236 | In a search for mediators of the p53 tumor suppressor pathway, which induces pleiotropic and often antagonistic cellular responses, we identified the long noncoding RNA (lncRNA) NEAT1. NEAT1 is an essential architectural component of paraspeckle nuclear bodies, whose pathophysiological relevance remains unclear. Activa... | p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity |
{"1039": 0.9958525896072388, "1043": 0.21372433006763458, "1051": 0.3910386264324188, "2003": 0.37974658608436584, "2008": 0.004870930220931768, "2011": 0.3850763738155365, "2029": 0.09050461649894714, "2063": 0.2478361576795578, "2079": 0.2223619967699051, "2080": 0.17431432008743286, "2094": 0.9576126337051392, "2109... | 21535641 | NADPH oxidase is a critical regulator of both antimicrobial host defense and inflammation. Activated in nature by microbes and microbial-derived products, the phagocyte NADPH oxidase is rapidly assembled, and generates reactive oxidant intermediates (ROIs) in response to infectious threat. Chronic granulomatous disease... | Regulation of innate immunity by NADPH oxidase. |
{"1020": 0.1718502640724182, "1039": 0.03360854089260101, "1044": 0.5936289429664612, "1051": 0.42225050926208496, "1062": 0.42990362644195557, "1999": 0.0913962796330452, "2004": 0.23402166366577148, "2005": 0.21214580535888672, "2007": 0.1930064558982849, "2011": 0.1751343309879303, "2020": 0.1602703034877777, "2029"... | 21547032 | Objective:In mice and in humans, treatment with the second-generation antipsychotic drug olanzapine (OLZ) produces excessive weight gain, adiposity and secondary metabolic complications, including loss of glucose and insulin homeostasis. In mice consuming a high-fat (HF) diet, a similar phenotype develops, which is inh... | Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole |
{"1052": 0.22626367211341858, "1999": 0.12384103983640671, "2003": 0.12986256182193756, "2005": 0.151916041970253, "2011": 0.25845035910606384, "2024": 0.13157635927200317, "2034": 0.24171993136405945, "2042": 0.08871890604496002, "2064": 0.21214580535888672, "2081": 0.08064348995685577, "2098": 0.4518963396549225, "21... | 21550246 | Prion diseases are caused by an unconventional infectious agent termed prion, composed mainly of the misfolded prion protein (PrPSc). The development of highly sensitive assays for biochemical detection of PrPSc in blood is a top priority for minimizing the spread of the disease. Here we show that the protein misfoldin... | Detection of prions in blood |
{"1011": 0.10731173306703568, "1013": 0.21765978634357452, "1017": 0.6096806526184082, "1042": 0.12814582884311676, "1047": 0.006812678650021553, "1052": 0.3910386264324188, "1998": 0.025073638185858727, "2007": 0.10467668622732162, "2011": 0.1401015669107437, "2012": 0.7305257320404053, "2029": 0.09406650811433792, "2... | 21551568 | PURPOSE To investigate the overall occurrence and relationship of genetic alterations in the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in thyroid tumors and explore the scope of this pathway as a therapeutic target for thyroid cancer. EXPERIMENTAL DESIGN We examined collectively the major genetic alterations and... | Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer. |
{"1013": 0.03831886500120163, "1016": 0.3601844012737274, "1038": 0.6275664567947388, "1040": 1.390192985534668, "1044": 0.13755162060260773, "2038": 0.0752234235405922, "2042": 0.0606246218085289, "2047": 0.12814582884311676, "2058": 0.34370049834251404, "2079": 0.018384648486971855, "2084": 0.15275461971759796, "2089... | 21553394 | In recent years, new functional roles of vitamin D beyond its traditional role in calcium homoeostasis and bone metabolism have emerged linking the fat-soluble vitamin to various non-communicable diseases. Vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) < 25-30 nmol/l) and sub-optimal status (25(OH)D < 50-100 nmol/... | Vitamin D and obesity: current perspectives and future directions. |
{"1039": 0.48850810527801514, "1052": 1.1555536985397339, "1996": 0.07431721687316895, "2005": 0.16276304423809052, "2008": 0.08154398202896118, "2010": 0.7370892763137817, "2011": 0.2539152204990387, "2012": 0.21214580535888672, "2029": 0.4311734735965729, "2076": 0.2478361576795578, "2079": 0.21293537318706512, "2089... | 21557055 | The tumor suppressor protein, p53, plays a critical role in mediating cellular response to stress signals by regulating genes involved in cell cycle arrest and apoptosis. p53 is believed to be inactive for DNA binding unless its C terminus is modified or structurally altered. We show that unmodified p53 actively binds ... | Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. |
{"1054": 0.6075552701950073, "2003": 0.19862671196460724, "2004": 0.0354953333735466, "2005": 0.20818853378295898, "2011": 0.31560876965522766, "2012": 0.2145126610994339, "2024": 0.30917787551879883, "2054": 0.18573370575904846, "2070": 0.129004567861557, "2072": 0.011650617234408855, "2079": 0.34508460760116577, "208... | 21557614 | Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are beneficial in the primary and secondary prevention of coronary heart disease. However, the overall benefits observed with statins appear to be greater than what might be expected from changes in lipid levels alone, suggesting eff... | Pleiotropic effects of statins. |
{"1011": 0.09672962874174118, "1021": 0.14939609169960022, "2000": 0.2990913391113281, "2003": 0.06886265426874161, "2005": 0.18573370575904846, "2007": 0.012615402229130268, "2008": 0.0058422754518687725, "2011": 0.011650617234408855, "2012": 0.06612417846918106, "2029": 0.16524957120418549, "2046": 0.4885081052780151... | 21561474 | Methods to introduce targeted double-strand breaks (DSBs) into DNA enable precise genome editing by increasing the rate at which externally supplied DNA fragments are incorporated into the genome through homologous recombination. The efficiency of these methods is limited by nonhomologous end joining (NHEJ), an alterna... | Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining |
{"1011": 0.1485546976327896, "1017": 0.22782009840011597, "1019": 0.36290550231933594, "1021": 0.0038986403960734606, "1043": 0.21530038118362427, "1047": 1.246605634689331, "1048": 0.19622190296649933, "1055": 0.009718249551951885, "1057": 0.613389253616333, "2002": 0.6950984001159668, "2011": 0.272677481174469, "2014... | 21562657 | K3/MIR1 and K5/MIR2 of Kaposi's sarcoma-associated herpesvirus (KSHV) are viral members of the membrane-associated RING-CH (MARCH) ubiquitin ligase family and contribute to viral immune evasion by directing the conjugation of ubiquitin to immunostimulatory transmembrane proteins. In a quantitative proteomic screen for ... | Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus. |
{"1009": 0.2317005842924118, "1011": 0.28963330388069153, "1051": 0.037378571927547455, "1052": 0.20022670924663544, "1059": 0.26146242022514343, "1155": 0.23556606471538544, "1156": 0.4337083101272583, "1999": 0.058784693479537964, "2003": 0.28597161173820496, "2004": 0.15275461971759796, "2011": 0.38308101892471313, ... | 21564598 | Periostin (Postn) is a matricellular protein preferentially expressed by osteocytes and periosteal osteoblasts in response to mechanical stimulation and parathyroid hormone (PTH). Whether and how periostin expression influences bone anabolism, however, remains unknown. We investigated the skeletal response of adult Pos... | Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin. |
{"1003": 0.06977381557226181, "1006": 0.18816383183002472, "1020": 0.04767346754670143, "1037": 0.5080875158309937, "1039": 0.13925230503082275, "1043": 0.4831010699272156, "1048": 0.3381449282169342, "1997": 0.19862671196460724, "2001": 0.02792670577764511, "2012": 0.07341018319129944, "2034": 0.036437395960092545, "2... | 21571708 | CONTEXT Circulating concentration of lipoprotein(a) (Lp[a]), a large glycoprotein attached to a low-density lipoprotein-like particle, may be associated with risk of coronary heart disease (CHD) and stroke. OBJECTIVE To assess the relationship of Lp(a) concentration with risk of major vascular and nonvascular outcomes.... | Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. |
{"1011": 0.3910386264324188, "1042": 0.5336109399795532, "1048": 0.07431721687316895, "2003": 0.21687394380569458, "2029": 0.043007105588912964, "2048": 0.46853771805763245, "2051": 0.5925496220588684, "2079": 0.011650617234408855, "2080": 0.09672962874174118, "2087": 0.08692999184131622, "2109": 0.04113444685935974, "... | 21578627 | An incoherent feed-forward loop (FFL) is one of the most-frequently observed motifs in biomolecular regulatory networks. It has been thought that the incoherent FFL is designed simply to induce a transient response shaped by a 'fast activation and delayed inhibition'. We find that the dynamics of various incoherent FFL... | The biphasic behavior of incoherent feed-forward loops in biomolecular regulatory networks. |
{"1016": 0.2105647772550583, "2001": 0.2607102394104004, "2005": 0.46363574266433716, "2015": 0.19541899859905243, "2020": 0.4177590310573578, "2035": 0.07159364968538284, "2040": 0.036437395960092545, "2043": 0.304147332906723, "2048": 0.030771657824516296, "2055": 0.00875066313892603, "2060": 0.3034266233444214, "206... | 21590125 | Data of prescribing practices for antipsychotics are of great interest with respect to quality of care. Consequently, we analysed all prescriptions under the statutory health insurance redeemed at pharmacies in Southern Germany between July 1999 and December 2001. The database covers prescriptions for approximately 25 ... | Antipsychotic prescribing patterns in Germany: a retrospective analysis using a large outpatient prescription database. |
{"1011": 0.33325836062431335, "1015": 0.40546512603759766, "1038": 0.06520967930555344, "1040": 0.6128603219985962, "1041": 0.9900637865066528, "1043": 0.3949938118457794, "1052": 0.49864232540130615, "1996": 0.0174254160374403, "1997": 0.12642613053321838, "1999": 0.037378571927547455, "2008": 0.055094651877880096, "2... | 21598000 | Plus-end tracking proteins, such as EB1 and the dynein/dynactin complex, regulate microtubule dynamics. These proteins are thought to stabilize microtubules by forming a plus-end complex at microtubule growing ends with ill-defined mechanisms. Here we report the crystal structure of two plus-end complex components, the... | Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex. |
{"1011": 0.18167030811309814, "1016": 0.034552380442619324, "1049": 0.03266380727291107, "2000": 0.11691460013389587, "2005": 0.29036402702331543, "2011": 0.34023189544677734, "2012": 0.03925827145576477, "2015": 0.7854343056678772, "2029": 0.2018241584300995, "2033": 0.0797421783208847, "2043": 0.05417001247406006, "2... | 21601459 | While most somatic cells undergoing induced pluripotent stem (iPS) cell reprogramming with Yamanaka factors accumulate at stable partially reprogrammed stages, the molecular mechanisms required to achieve full reprogramming are unknown. MicroRNAs (miRNAs) fine-tune mRNA translation and are implicated in reprogramming, ... | Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming. |
{"1011": 0.1677299439907074, "1041": 1.0628231763839722, "1043": 0.23556606471538544, "1047": 0.823009729385376, "1060": 0.6714286804199219, "1999": 0.15943801403045654, "2000": 0.03925827145576477, "2011": 0.3870677351951599, "2013": 0.16359257698059082, "2020": 0.011650617234408855, "2029": 0.04674193635582924, "2043... | 21602220 | The physiology of ethanologenic Escherichia coli grown anaerobically in alkali-pretreated plant hydrolysates is complex and not well studied. To gain insight into how E. coli responds to such hydrolysates, we studied an E. coli K-12 ethanologen fermenting a hydrolysate prepared from corn stover pretreated by ammonia fi... | Complex physiology and compound stress responses during fermentation of alkali-pretreated corn stover hydrolysate by an Escherichia coli ethanologen. |
{"1014": 0.24325250089168549, "1019": 0.33953672647476196, "1020": 0.18411032855510712, "1028": 0.08782484382390976, "1044": 0.7201237678527832, "1052": 0.3897167444229126, "1062": 0.5718178153038025, "2001": 0.10993985831737518, "2002": 0.02887592278420925, "2020": 0.026025565341114998, "2034": 0.1619328260421753, "20... | 21616324 | BACKGROUND Control of blood pressure (BP) following renal transplantation may improve allograft and patient survival. Our aims were (i) to describe the distribution of BP and the prevalence of systolic and/or diastolic hypertension in children over the first 5 years following renal transplantation and (ii) to evaluate ... | Systemic arterial hypertension in children following renal transplantation: prevalence and risk factors. |
{"1011": 0.22157983481884003, "1015": 0.3325583338737488, "1017": 0.11256109178066254, "1039": 0.41065993905067444, "1042": 0.565735399723053, "1052": 0.3084607720375061, "1997": 0.020300358533859253, "2002": 0.7352184057235718, "2004": 0.036437395960092545, "2006": 0.09938567131757736, "2008": 0.026976587250828743, "2... | 21622715 | Transcriptional factors binding to cAMP-responsive elements (CREs) in the promoters of various genes belong to the basic domain-leucine zipper superfamily and are composed of three genes in mammals, CREB, CREM, and ATF-1. A large number of CREB, CREM, and ATF-1 proteins are generated by posttranscriptional events, most... | Coupling cAMP signaling to transcription in the liver: pivotal role of CREB and CREM. |
{"1003": 0.026976587250828743, "1014": 0.6907027959823608, "1018": 0.22079704701900482, "1021": 0.4932899475097656, "1022": 0.10203468054533005, "1039": 0.7389566898345947, "1040": 0.4950772523880005, "1041": 0.567397952079773, "1042": 0.13157635927200317, "1053": 0.20022670924663544, "1055": 0.7028654217720032, "1997"... | 21623140 | Objective: The main objective of the study was to develop appropriate dietary assessment instruments for the French Mediterranean region and to validate the measurements they provide. Subjects and Methods: Three different assessment methods were submitted to a sample of 150 male and female volunteers. 98 completed the ... | Comparison of dietary assessment methods in a Southern French population: use of weighed records, estimated-diet records and a food-frequency questionnaire |
{"1011": 0.11081436276435852, "1017": 0.41065993905067444, "1018": 0.2659635543823242, "1020": 0.44691193103790283, "1023": 0.3191637098789215, "1043": 0.3560888469219208, "1052": 0.7314660549163818, "1056": 0.6170841455459595, "2011": 0.02316705882549286, "2015": 0.304147332906723, "2029": 0.10026945173740387, "2048":... | 21626639 | Macrophages play a relevant role in innate and adaptive immunity depending on the balance of the stimuli received. From an analytical and functional point of view, macrophage stimulation can be segregated into three main modes, as follows: innate, classic, and alternative pathways. These differential activations result... | Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. |
{"1014": 0.11951763927936554, "1020": 0.16607704758644104, "1042": 1.049919843673706, "1052": 0.24018502235412598, "2000": 0.23864774405956268, "2005": 0.3897167444229126, "2050": 0.0752234235405922, "2052": 0.19381128251552582, "2063": 0.09406650811433792, "2064": 0.02412080205976963, "2087": 0.2852376699447632, "2109... | 21636085 | BACKGROUND Increased plasma homocysteine is associated with coronary artery disease, peripheral vascular disease and venous thrombosis. Folic acid is the most effective therapy for reducing homocysteine levels. The lowest effective supplement of folic acid is not known, particularly for the elderly who have the highest... | The effect of folic acid supplementation on plasma homocysteine in an elderly population. |
{"1005": 0.09850110858678818, "1014": 0.41389304399490356, "1017": 0.5562619566917419, "1019": 0.7701805830001831, "1043": 0.47158926725387573, "1044": 0.15777134895324707, "1052": 0.3949938118457794, "2003": 0.26446542143821716, "2007": 0.04860413447022438, "2012": 0.1994270235300064, "2014": 0.5301685929298401, "2020... | 21641088 | Obesity is a multifactorial disease with a marked genetic component. The situation is further complicated by the heterogeneity of obesity demonstrated by the topographical distribution of body fat, e.g. upper body (central) and lower body (gluteal) obesity. Furthermore, the distribution of fat shows a stronger heritabl... | Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5' flanking region of the human insulin gene. |
{"1013": 0.19862671196460724, "1018": 0.09672962874174118, "1019": 0.3262358605861664, "1044": 0.3423145115375519, "1048": 0.5590575933456421, "1049": 0.28450319170951843, "1050": 0.03925827145576477, "1052": 0.6808650493621826, "1053": 1.072225570678711, "1055": 0.3615458607673645, "1061": 0.272677481174469, "2000": 0... | 21644993 | Bacterial vaccines can reduce carriage rates. Colonization is usually a binary endpoint. Real time quantitative PCR (qPCR) can quantify bacterial DNA in mucosal samples over a wide range. Using culture and single-gene species-specific qPCRs for Streptococcus pneumoniae (lytA), Streptococcus pyogenes (ntpC), Moraxella c... | Population density profiles of nasopharyngeal carriage of 5 bacterial species in pre-school children measured using quantitative PCR offer potential insights into the dynamics of transmission. |
{"1006": 0.006812678650021553, "1011": 0.015504186972975731, "1017": 0.19622190296649933, "1038": 0.950843095779419, "1040": 0.06337817758321762, "1043": 0.42096930742263794, "1996": 0.2637155055999756, "1999": 0.0174254160374403, "2011": 0.2394166737794876, "2015": 0.013579257763922215, "2029": 0.18654440343379974, "2... | 21645205 | A core group of regulatory factors control circadian rhythms in mammalian cells. While the suprachiasmatic nucleus in the brain serves as the central core circadian oscillator, circadian clocks also exist within peripheral tissues and cells. A growing body of evidence has demonstrated that >20% of expressed mRNAs in bo... | Circadian mechanisms in murine and human bone marrow mesenchymal stem cells following dexamethasone exposure. |
{"1043": 0.7491656541824341, "1996": 0.06429435312747955, "1999": 0.08154398202896118, "2005": 0.13499516248703003, "2008": 0.1221139207482338, "2014": 1.2566616535186768, "2015": 0.3560888469219208, "2016": 0.12986256182193756, "2024": 0.14095009863376617, "2029": 0.25694093108177185, "2030": 0.8004589080810547, "2037... | 21651116 | Herpesviruses encode membrane-associated G protein-coupled receptors (GPCRs) in their viral genomes that are structurally similar to chemokine receptors. These GPCRs hijack GPCR-mediated cellular signalling networks of the host for survival, replication and pathogenesis. In particular the herpesvirus-encoded chemokine ... | Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases? |
{"1011": 0.0019512200960889459, "1049": 0.27044451236724854, "1050": 0.15777134895324707, "1996": 0.469759464263916, "1999": 0.02887592278420925, "2003": 0.28082266449928284, "2004": 0.24248650670051575, "2011": 0.27934664487838745, "2024": 0.20977331697940826, "2029": 0.015504186972975731, "2033": 0.009718249551951885... | 21676556 | The midbody is a singular organelle formed between daughter cells during cytokinesis and required for their final separation. Midbodies persist in cells long after division as midbody derivatives (MBds), but their fate is unclear. Here we show that MBds are inherited asymmetrically by the daughter cell with the older c... | Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity |
{"1015": 0.007782140281051397, "1041": 0.5718178153038025, "1043": 0.7827593088150024, "1050": 0.7925328612327576, "1998": 0.08244366943836212, "2011": 0.015504186972975731, "2015": 0.15023678541183472, "2024": 0.05694137513637543, "2029": 0.1477125883102417, "2033": 0.6764062643051147, "2046": 0.27712854743003845, "20... | 21692235 | The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of... | Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. |
{"1038": 0.8641747236251831, "1044": 0.7482418417930603, "1056": 0.8425432443618774, "2000": 0.015504186972975731, "2002": 1.1217793226242065, "2004": 0.27786844968795776, "2005": 0.29255300760269165, "2007": 0.304147332906723, "2010": 0.27712854743003845, "2011": 0.09495500475168228, "2032": 0.2223619967699051, "2034"... | 21700295 | Importance More than 240 million individuals worldwide are infected with chronic hepatitis B virus (HBV). Among individuals with chronic HBV infection who are untreated, 15% to 40% progress to cirrhosis, which may lead to liver failure and liver cancer. Observations Pegylated interferon and nucleos(t)ide analogues (lam... | Chronic Hepatitis B Infection: A Review |
{"1009": 0.37371641397476196, "1011": 0.3353555500507355, "1040": 0.12814582884311676, "1045": 0.4932899475097656, "1048": 0.7182208299636841, "1049": 0.4093637466430664, "1056": 0.6332852244377136, "1157": 0.6286086440086365, "1999": 0.16276304423809052, "2004": 0.10026945173740387, "2008": 0.10993985831737518, "2011"... | 21719289 | Although most vaccines are administered i.m., little is known about the dendritic cells (DCs) that are present within skeletal muscles. In this article, we show that expression of CD64, the high-affinity IgG receptor FcγRI, distinguishes conventional DCs from monocyte-derived DCs (Mo-DCs). By using such a discriminator... | CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization. |
{"1011": 0.4728073179721832, "1049": 0.7881022095680237, "1056": 1.068206787109375, "1996": 0.1994270235300064, "1998": 0.19220098853111267, "2003": 0.083342544734478, "2012": 0.13499516248703003, "2029": 0.045809537172317505, "2034": 0.42161011695861816, "2047": 0.24401791393756866, "2050": 0.3526630103588104, "2054":... | 21746539 | Much excitement of the past five years in the area of T-cell-antigen recognition has centred around the immunological synapse — a complex cellular structure that forms at the interface of a T cell and a cell that expresses the appropriate peptide–MHC complexes. Thanks to new imaging technologies, we are now beginning t... | T-cell-antigen recognition and the immunological synapse |
{"1011": 0.3423145115375519, "1015": 0.659380316734314, "1017": 0.036437395960092545, "1020": 0.07250232994556427, "1038": 0.8845420479774475, "1043": 0.8583967685699463, "1047": 0.680370569229126, "1050": 0.09495500475168228, "1054": 0.7144040465354919, "1056": 0.9363996982574463, "1061": 0.3070250153541565, "1997": 0... | 21754541 | Class B GPCRs can activate multiple signalling effectors with the potential to exhibit biased agonism in response to ligand stimulation. Previously, we highlighted key TM domain polar amino acids that were crucial for the function of the GLP-1 receptor, a key therapeutic target for diabetes and obesity. Using a combina... | Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor. |
{"2000": 0.37035053968429565, "2003": 0.12556517124176025, "2004": 0.0029254043474793434, "2005": 0.34577593207359314, "2034": 0.02316705882549286, "2064": 0.1401015669107437, "2075": 0.04953393340110779, "2079": 0.04674193635582924, "2094": 0.7827593088150024, "2109": 0.15860503911972046, "2166": 0.036437395960092545,... | 21767325 | Arterial stiffness and wave reflections exert a number of adverse effects on cardiovascular function and disease risk and are associated with a greater rate of mortality in patients with end-stage renal failure and essential hypertension. Accordingly, the prevention and treatment of arterial stiffness are of paramount ... | Influence of lifestyle modification on arterial stiffness and wave reflections. |
{"1009": 0.23556606471538544, "1011": 0.11604541540145874, "1013": 0.034552380442619324, "1014": 0.11430477350950241, "1026": 0.09672962874174118, "1038": 0.1930064558982849, "1045": 0.684319257736206, "1052": 0.23479416966438293, "1053": 1.210591435432434, "1056": 0.175953671336174, "1999": 0.1619328260421753, "2007":... | 21789744 | An increased spatial dispersion of ventricular repolarization duration (QT dispersion) is associated with an increased vulnerability to arrhythmias. This study was designed to examine the effect of exercise on QT dispersion in ischemic heart disease (IHD). QT dispersion, corrected QT dispersion, and percentage change i... | Effect of exercise-induced ischemia on QT interval dispersion. |
{"1017": 0.04767346754670143, "1020": 0.20022670924663544, "2007": 0.27342069149017334, "2015": 0.11256109178066254, "2043": 0.47827014327049255, "2044": 0.12384103983640671, "2048": 0.055094651877880096, "2051": 0.4196864068508148, "2064": 0.10731173306703568, "2077": 0.472198486328125, "2086": 0.037378571927547455, "... | 21790313 | This study reports the effects of powered mobility on the self-initiated behavior of six children with various disabilities who, between 23 and 38 months of age, learnt to use motorized wheelchairs in less than three weeks. Using a multiple baseline design, two-hour observation periods were video-recorded at 10-day int... | Effects of powered mobility on self-initiated behaviors of very young children with locomotor disability. |
{"1011": 0.1930064558982849, "1013": 0.0038986403960734606, "1038": 0.07341018319129944, "1039": 0.026976587250828743, "1048": 0.29255300760269165, "1157": 0.12384103983640671, "2006": 0.7105726003646851, "2008": 0.07793712615966797, "2011": 0.306306391954422, "2029": 0.41389304399490356, "2044": 0.4450363218784332, "2... | 21793890 | The oncogenic BCR/ABL tyrosine kinase facilitates the repair of DNA double-strand breaks (DSBs). We find that after gamma-irradiation BCR/ABL-positive leukemia cells accumulate more DSBs in comparison to normal cells. These lesions are efficiently repaired in a time-dependent fashion by BCR/ABL-stimulated non-homologou... | BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells. |
{"1038": 1.237014651298523, "2003": 0.04394211992621422, "2005": 0.04207121208310127, "2029": 0.11778303235769272, "2079": 0.16524957120418549, "2109": 0.15860503911972046, "2350": 0.4349733293056488, "2377": 0.2089812457561493, "2458": 0.6754127144813538, "2487": 0.025073638185858727, "2515": 0.11517547070980072, "253... | 21804115 | Bone morphogenetic protein (BMP) signaling plays an essential role in many aspects of kidney development, and is a major determinant of outcome in kidney injury. BMP treatment is also an essential component of protocols for differentiation of nephron progenitors from pluripotent stem cells. This review discusses the ro... | Bone morphogenetic protein signaling in nephron progenitor cells |
{"1005": 0.1602703034877777, "1006": 0.2983669638633728, "1011": 0.2105647772550583, "1017": 0.4437839686870575, "1037": 0.012615402229130268, "1052": 0.11951763927936554, "1998": 0.043007105588912964, "2003": 0.1889725625514984, "2008": 0.08513788133859634, "2011": 0.034552380442619324, "2013": 0.3464667797088623, "20... | 21853444 | Alternative initiation, splicing, and polyadenylation are key mechanisms used by many organisms to generate diversity among mature mRNA transcripts originating from the same transcription unit. While previous computational analyses of alternative polyadenylation have focused on polyadenylation activities within or down... | Computational analysis of 3'-ends of ESTs shows four classes of alternative polyadenylation in human, mouse, and rat. |
{"1040": 0.15777134895324707, "1050": 0.6038249135017395, "2003": 0.0842406153678894, "2011": 0.5640701055526733, "2013": 0.38308101892471313, "2020": 0.13243216276168823, "2029": 0.1602703034877777, "2054": 0.37974658608436584, "2057": 0.0038986403960734606, "2058": 0.4944818615913391, "2075": 0.32058215141296387, "20... | 21855837 | Cloning by nuclear transfer (NT) is an inefficient process in which most clones die before birth and survivors often display growth abnormalities. In an effort to correlate gene expression with survival and fetal overgrowth, we have examined imprinted gene expression in both mice cloned by nuclear transfer and in the e... | Epigenetic instability in ES cells and cloned mice. |
{"1013": 0.38441169261932373, "1044": 0.5816917419433594, "1047": 1.3784512281417847, "1057": 0.2447827309370041, "2000": 0.15777134895324707, "2002": 0.0913962796330452, "2003": 0.052318159490823746, "2005": 0.05970508232712746, "2007": 0.013579257763922215, "2015": 0.17759032547473907, "2020": 0.06886265426874161, "2... | 21859699 | Providing transplantation opportunities for patients with incompatible live donors through kidney paired donation (KPD) is seen as one of the important strategies for easing the crisis in organ availability. It has been estimated that an additional 1000-2000 transplants per year could be accomplished if a national KPD ... | Successful three-way kidney paired donation with cross-country live donor allograft transport. |
{"1003": 0.03925827145576477, "1011": 0.11343330889940262, "1043": 0.3777405619621277, "1054": 0.4311734735965729, "1996": 0.1970241367816925, "1999": 0.12642613053321838, "2005": 0.04394211992621422, "2008": 0.1221139207482338, "2011": 0.23864774405956268, "2024": 0.13925230503082275, "2029": 0.20501139760017395, "207... | 21866916 | Astrocytes represent at least 50% of the volume of the human brain. Besides their roles in various supportive functions, astrocytes are involved in the regulation of stem cell proliferation, synaptic plasticity and neuroprotection. Astrocytes also influence neuronal physiology by responding to neurotransmitters and neu... | Role of PACAP and VIP in astroglial functions. |
{"1013": 0.10467668622732162, "1048": 0.3423145115375519, "1057": 0.8682814836502075, "1999": 0.5341835021972656, "2003": 0.28963330388069153, "2004": 0.09317722171545029, "2012": 0.3283478021621704, "2015": 0.39696553349494934, "2022": 0.05139094591140747, "2026": 0.8109301924705505, "2029": 0.17922431230545044, "2043... | 21868715 | Molecular mechanisms leading to myocardial injury during warm or cold ischemia are insufficiently understood. Although proteasomes are thought to contribute to myocardial ischemia-reperfusion injury, their roles during the ischemic period remain elusive. Because donor hearts are commonly exposed to prolonged global col... | A subset of 26S proteasomes is activated at critically low ATP concentrations and contributes to myocardial injury during cold ischemia. |
{"1043": 1.071556806564331, "1044": 0.18167030811309814, "1053": 0.3019835948944092, "1997": 0.09050461649894714, "2001": 0.004870930220931768, "2006": 0.41195443272590637, "2007": 0.1710275560617447, "2012": 0.00875066313892603, "2018": 0.11430477350950241, "2020": 0.2478361576795578, "2022": 0.018384648486971855, "20... | 21870716 | The ability of children to cope with a chronic medical problem requiring prolonged treatment has an effect on the quality of life of these children and of their parents and serves as an index of the quality of treatment. This study deals with coping ability and satisfaction with treatment of children whose stature was ... | Coping and satisfaction with growth hormone treatment among short-stature children. |
{"1018": 0.09584271162748337, "2001": 0.052318159490823746, "2022": 0.08961215615272522, "2039": 0.2539152204990387, "2042": 0.13157635927200317, "2043": 0.1064341589808464, "2051": 0.7305257320404053, "2052": 0.0770333781838417, "2073": 0.0770333781838417, "2086": 0.6563454270362854, "2095": 0.14602625370025635, "2111... | 21874312 | A classification of risk for developing breast cancer has been devised based solely on the appearance of the breast parenchyma by mammography. Four groups of patients were isolated. The study encompassed a five-year period and was done by reviewing the mammograms of all women over the age of 30 who had been examined at... | Risk for breast cancer development determined by mammographic parenchymal pattern. |
{"1011": 0.41389304399490356, "1017": 0.25694093108177185, "1040": 0.7827593088150024, "2003": 0.10555581003427505, "2005": 0.02316705882549286, "2064": 0.1477125883102417, "2075": 0.8366385698318481, "2093": 0.43812891840934753, "2098": 0.6181373596191406, "2109": 0.5472630262374878, "2129": 0.1994270235300064, "2181"... | 21874414 | We develop a systematic coarse-graining procedure for modeling red blood cells (RBCs) using arguments based on mean-field theory. The three-dimensional RBC membrane model takes into account the bending energy, in-plane shear energy, and constraints of fixed surface area and fixed enclosed volume. The coarse-graining pr... | Accurate coarse-grained modeling of red blood cells. |
{"1011": 0.10203468054533005, "1016": 0.23015019297599792, "1018": 0.6075552701950073, "1022": 0.20739519596099854, "1039": 0.3864043951034546, "1049": 0.603290855884552, "1056": 0.9687942266464233, "1059": 0.6102113127708435, "1999": 0.009718249551951885, "2005": 0.1873544454574585, "2008": 0.0009760859538801014, "201... | 21878751 | CD4 T cells are important in the protective immune response against tuberculosis. Two mouse models deficient in CD4 T cells were used to examine the mechanism by which these cells participate in protection against Mycobacterium tuberculosis challenge. Transgenic mice deficient in either MHC class II or CD4 molecules de... | Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis. |
{"1011": 0.4617912769317627, "1043": 1.001607894897461, "1058": 0.5104349255561829, "2003": 0.3499138653278351, "2005": 0.09850110858678818, "2035": 0.38574060797691345, "2045": 0.32270604372024536, "2084": 0.09672962874174118, "2087": 0.0770333781838417, "2090": 0.0913962796330452, "2094": 0.2786078155040741, "2102": ... | 21884059 | Graft-versus-host disease (GVHD) is a significant cause of morbidity and mortality following allogenic haematopoietic stem-cell transplantation and thus the focus of much ongoing research. Despite considerable advances in our understanding of the pathophysiology, diagnosis and predisposing factors for both acute and ch... | Treatment and management of graft-versus-host disease: improving response and survival. |
{"1019": 0.11430477350950241, "1020": 0.04487626627087593, "1042": 0.5483922958374023, "1052": 0.1384023278951645, "1054": 0.8715548515319824, "1997": 0.18167030811309814, "2001": 0.04394211992621422, "2007": 0.04767346754670143, "2015": 0.6410312056541443, "2019": 0.2637155055999756, "2053": 0.1734936386346817, "2064"... | 21884449 | AIMS To explore the utility of self-report measures of inhaled corticosteroid (ICS) adherence, degree of rhinitis and smoking status and their association with asthma control. METHODS Patients prescribed ICS for asthma at 85 UK practices were sent validated questionnaire measures of control (Asthma Control Questionnair... | The value of self-report assessment of adherence, rhinitis and smoking in relation to asthma control. |
{"1009": 0.17431432008743286, "1011": 0.08603433519601822, "1017": 0.0174254160374403, "1019": 0.0174254160374403, "1039": 0.34370049834251404, "1051": 0.7647408246994019, "1055": 0.0317181795835495, "1999": 0.06429435312747955, "2004": 0.4879087805747986, "2007": 0.18573370575904846, "2010": 0.6502478122711182, "2011"... | 21891856 | Mouse ovarian surface epithelial cells (MOSEC) were obtained from virgin, mature mice by mild trypsinization and were repeatedly passaged in vitro. Early passage cells (<20 passages) exhibited a cobblestone morphology and contact inhibition of growth. After approximately 20 passages in vitro, cobblestone morphology and... | Development of a syngeneic mouse model for events related to ovarian cancer. |
{"1011": 0.03266380727291107, "1041": 0.4267219603061676, "1043": 0.2089812457561493, "1044": 0.8357921838760376, "1051": 0.14264501631259918, "2002": 0.029824240133166313, "2003": 0.28597161173820496, "2064": 0.08244366943836212, "2075": 0.22001366317272186, "2080": 0.37102460861206055, "2102": 0.3325583338737488, "21... | 21902400 | Hypoxia, a characteristic feature of locally advanced solid tumors, has emerged as a pivotal factor of the tumor (patho-)physiome since it can promote tumor progression and resistance to therapy. Hypoxia represents a “Janus face” in tumor biology because (a) it is associated with restrained proliferation, differentiati... | Hypoxia in cancer: significance and impact on clinical outcome |
{"1998": 0.03266380727291107, "2000": 0.175953671336174, "2005": 0.3304552733898163, "2006": 0.3995884954929352, "2007": 0.0009760859538801014, "2020": 0.0317181795835495, "2025": 0.05786345899105072, "2044": 0.43875885009765625, "2055": 0.0354953333735466, "2063": 0.09406650811433792, "2071": 0.27564704418182373, "207... | 21902910 | OBJECTIVES To assess the knowledge of interns on standard precautions and post-exposure prophylaxis for HIV, and identify the gap between knowledge and practice relating to standard precautions, as well as determining the perceived barriers against adherence to standard precautions. METHODS The study was conducted on 1... | Knowledge and Practice of Standard Precautions and Awareness Regarding Post-Exposure Prophylaxis for HIV among Interns of a Medical College in West Bengal, India. |
{"2011": 0.026976587250828743, "2014": 0.3297532796859741, "2015": 0.19541899859905243, "2038": 0.06977381557226181, "2047": 0.10993985831737518, "2050": 0.07341018319129944, "2064": 0.03266380727291107, "2071": 0.2026219218969345, "2078": 0.5021947622299194, "2079": 0.28743788599967957, "2089": 0.2247048318386078, "21... | 21909315 | The discovery of RNA interference and cellular microRNAs (miRNAs) has not only affected how biological research is conducted but also revealed an entirely new level of post-transcriptional gene regulation. Here, I discuss the potential functions of the virally encoded miRNAs recently identified in several pathogenic hu... | Viruses and microRNAs |
{"1043": 0.8764448165893555, "1051": 0.46853771805763245, "2000": 0.029824240133166313, "2043": 0.06886265426874161, "2050": 0.3269403576850891, "2058": 0.0752234235405922, "2086": 0.05694137513637543, "2088": 0.38574060797691345, "2095": 0.07341018319129944, "2097": 0.013579257763922215, "2111": 0.014542185701429844, ... | 21914176 | BACKGROUND Glaucoma is the World's leading cause of irreversible blindness, and poses serious public health and economic concerns. DESIGN Review. SAMPLES Published randomized trials and population-based studies since 1985. METHODS We report the economic impact of primary open-angle glaucoma and model the effect of ch... | Economic impact of primary open-angle glaucoma in Australia. |
{"1011": 0.34023189544677734, "1015": 0.6502478122711182, "1017": 0.5197699069976807, "1060": 0.8691008687019348, "1061": 0.0029254043474793434, "1996": 0.03831886500120163, "1999": 0.12038381397724152, "2003": 0.20660123229026794, "2008": 0.11517547070980072, "2011": 0.3127557039260864, "2012": 0.16110190749168396, "2... | 21922424 | A novel cysteine-rich motif, named LIM, has been identified in the homeo box genes lin-11, Isl-1, and mec-3; the mec-3 and lin-11 genes determine cell lineages in Caenorhabditis elegans. We isolated LIM class homeo box genes from Xenopus laevis that are closely related to lin-11 and mec-3 in the LIM and homeo domains. ... | The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. |
{"1011": 0.14264501631259918, "1017": 0.004870930220931768, "1020": 0.823009729385376, "1038": 0.0038986403960734606, "1039": 0.3949938118457794, "1043": 0.8845420479774475, "1046": 0.23633737862110138, "1052": 0.40220460295677185, "2001": 0.014542185701429844, "2007": 0.3409265875816345, "2011": 0.4126010537147522, "2... | 21931005 | Permeabilized rat kidney cells rapidly released glucose 6-phosphate dehydrogenase (G6PD) following stimulation with peptide growth factors (Stanton, R.C., Seifter, J.L., Boxer, D.C., Zimmerman, E., and Cantley, L. C. (1991) J. Biol. Chem. 266, 12442-12448). To evaluate the signal transduction pathways mediating release... | Signal transduction proteins that associate with the platelet-derived growth factor (PDGF) receptor mediate the PDGF-induced release of glucose-6-phosphate dehydrogenase from permeabilized cells. |
{"1044": 0.5483922958374023, "1049": 0.28082266449928284, "1058": 0.2531573474407196, "2002": 0.28155985474586487, "2003": 0.39367714524269104, "2011": 0.01934296265244484, "2026": 0.6654226183891296, "2029": 0.06977381557226181, "2033": 0.16524957120418549, "2064": 0.18329764902591705, "2076": 0.21293537318706512, "20... | 21932050 | Human cytomegalovirus (HCMV) is one of the largest known DNA viruses. It is ubiquitous, and following resolution of primary productive infection, it persists in the human host by establishing a lifelong latent infection in myeloid lineage cells such as monocytes and their progenitors. Most adults with HCMV infection ar... | Microarrays for the study of viral gene expression during human cytomegalovirus latent infection. |
{"1006": 0.1718502640724182, "1007": 0.12556517124176025, "1011": 0.13670019805431366, "1016": 0.8949713706970215, "1044": 1.2301886081695557, "1051": 0.14095009863376617, "1055": 0.9409833550453186, "1175": 0.0038986403960734606, "1997": 0.20022670924663544, "2002": 0.45623743534088135, "2004": 0.020300358533859253, "... | 21932297 | The important life-supporting role of hydrogen sulfide (H(2)S) has evolved from bacteria to plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H(2)S had only been known for its toxicity and environmental hazard. Physiological importance of H(2)S has been appreciated for about a dec... | Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. |
{"1011": 0.1946154683828354, "1038": 0.44753631949424744, "1044": 0.026025565341114998, "1056": 0.38574060797691345, "1997": 0.014542185701429844, "1998": 0.10026945173740387, "1999": 0.15943801403045654, "2003": 0.043007105588912964, "2004": 0.11256109178066254, "2005": 0.15275461971759796, "2007": 0.14686977863311768... | 21943141 | The recent discovery of a ubiquitous translocation pathway, specifically required for proteins with a twin-arginine motif in their signal peptide, has focused interest on its membrane-bound components, one of which is known as TatC. Unlike most organisms of which the genome has been sequenced completely, the Gram-posit... | TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway. |
{"1011": 0.29400965571403503, "1057": 0.8941729068756104, "2000": 0.02316705882549286, "2003": 0.02412080205976963, "2007": 0.09050461649894714, "2008": 0.09228714555501938, "2011": 0.4425300657749176, "2015": 0.15610189735889435, "2029": 0.2652147710323334, "2048": 0.28155985474586487, "2064": 0.21293537318706512, "20... | 21948782 | Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins is highly dynamic, and both SUMO–protein conjugation and cleavage can be regulated. Protein desumoylation is carried out by SUMO proteases, which control cellular mechanisms ranging from transcription and cell division to ribosome biogenesis. Recen... | Function and regulation of SUMO proteases |
{"1052": 0.06520967930555344, "2003": 0.3743882179260254, "2005": 0.06154331564903259, "2011": 0.06520967930555344, "2015": 0.4412745535373688, "2021": 0.23710809648036957, "2024": 0.48068851232528687, "2054": 0.05786345899105072, "2063": 0.10731173306703568, "2066": 0.20501139760017395, "2077": 0.12038381397724152, "2... | 21956124 | BACKGROUND Prebiotics are short-chain carbohydrates that alter the composition, or metabolism, of the gut microbiota in a beneficial manner. It is therefore expected that prebiotics will improve health in a way similar to probiotics, whilst at the same time being cheaper, and carrying less risk and being easier to inco... | Review article: prebiotics in the gastrointestinal tract. |
{"1011": 0.07612881064414978, "1017": 0.5244048833847046, "1043": 0.46117570996284485, "1998": 0.02316705882549286, "2020": 0.02792670577764511, "2028": 0.23556606471538544, "2029": 0.05417001247406006, "2058": 0.4831010699272156, "2074": 0.3027053773403168, "2090": 0.4145384132862091, "2092": 0.2969166338443756, "2093... | 21957231 | The aim of the present study was to examine the association between pain catastrophizing and general health status in a Dutch adult community sample, including various subgroups of people with musculoskeletal pain in the analyses. For exploratory reasons this study partly replicated previous studies of the factor struc... | Pain catastrophizing and general health status in a large Dutch community sample. |
{"1014": 0.05970508232712746, "1020": 0.0058422754518687725, "2000": 0.23247487843036652, "2004": 0.6573580503463745, "2005": 0.22157983481884003, "2007": 0.1619328260421753, "2012": 0.13243216276168823, "2020": 0.06520967930555344, "2034": 0.2317005842924118, "2052": 0.21530038118362427, "2060": 0.34370049834251404, "... | 21958900 | OBJECTIVE To compare the relative risks of serious gastrointestinal complications reported with individual non-steroidal anti-inflammatory drugs. DESIGN Systematic review of controlled epidemiological studies that found a relation between use of the drugs and admission to hospital for haemorrhage or perforation. SETTIN... | Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis. |
{"1013": 0.19541899859905243, "1014": 0.5573811531066895, "1021": 1.020087480545044, "1046": 0.1619328260421753, "1049": 0.5629584193229675, "1050": 0.32905077934265137, "1998": 0.14602625370025635, "2051": 0.1229778528213501, "2087": 0.029824240133166313, "2090": 0.40546512603759766, "2109": 0.05046287178993225, "2111... | 21993510 | OBJECTIVE To provide an independent evaluation of seven day weighed dietary records, which are currently accepted as the most accurate technique for assessing habitual dietary intake in studies investigating the links between diet and health. DESIGN Subjects who had previously participated in the Northern Ireland diet ... | Accuracy of weighed dietary records in studies of diet and health. |
{"1011": 0.1751343309879303, "1020": 0.4093637466430664, "1023": 0.2145126610994339, "1996": 0.03360854089260101, "1997": 0.17840765416622162, "1999": 0.14264501631259918, "2004": 0.8592242002487183, "2005": 0.056018441915512085, "2007": 0.0009760859538801014, "2008": 0.045809537172317505, "2011": 0.19862671196460724, ... | 22003328 | Clustered regularly interspaced short palindromic repeats (CRISPRs) together with the associated CAS proteins protect microbial cells from invasion by foreign genetic elements using presently unknown molecular mechanisms. All CRISPR systems contain proteins of the CAS2 family, suggesting that these uncharacterized prot... | A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. |
{"1014": 0.3601844012737274, "1026": 0.09406650811433792, "1038": 0.5370414853096008, "1052": 0.3241194784641266, "1081": 0.0913962796330452, "1156": 0.7500885725021362, "1597": 0.0317181795835495, "1609": 0.49030399322509766, "1998": 0.1751343309879303, "2012": 0.0019512200960889459, "2034": 0.40546512603759766, "2043... | 22007333 | Menstrual and reproductive factors may increase breast cancer risk through a pathway that includes increased mammographic density. We assessed whether known or suspected menstrual and reproductive breast cancer risk factors were cross-sectionally associated with mammographic density, by measuring area of radiographic d... | Menstrual and reproductive factors in relation to mammographic density: the Study of Women’s Health Across the Nation (SWAN) |
{"1009": 0.4437839686870575, "1014": 0.007782140281051397, "1020": 0.2837681770324707, "1040": 1.2677175998687744, "1055": 0.5540198087692261, "1999": 0.036437395960092545, "2007": 0.025073638185858727, "2012": 0.3923587501049042, "2029": 0.09495500475168228, "2090": 0.02412080205976963, "2093": 0.10203468054533005, "2... | 22023404 | CONTEXT Vitamin D deficiency is associated with many adverse health outcomes, yet little is known about the genetic epidemiology of vitamin D or its metabolites. OBJECTIVE Our objective was to examine the relationship among three vitamin D-related genes and levels of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvita... | Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. |
{"1011": 0.06886265426874161, "1015": 0.1064341589808464, "1018": 0.21765978634357452, "1019": 0.026976587250828743, "1043": 0.49030399322509766, "1052": 0.2881702482700348, "1999": 0.9155091643333435, "2007": 0.17020416259765625, "2011": 0.2478361576795578, "2015": 0.12642613053321838, "2019": 0.37707099318504333, "20... | 22025252 | The formation of inositol phosphates in response to agonists was studied in brain slices, parotid gland fragments and in the insect salivary gland. The tissues were first incubated with [3H]inositol, which was incorporated into the phosphoinositides. All the tissues were found to contain glycerophosphoinositol, inosito... | Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. |
{"1011": 0.37102460861206055, "1039": 0.37102460861206055, "1043": 0.8917738795280457, "1048": 0.9425065517425537, "1996": 0.13755162060260773, "1997": 0.14349138736724854, "1999": 0.28155985474586487, "2003": 0.08154398202896118, "2008": 0.07793712615966797, "2011": 0.2622140049934387, "2019": 0.014542185701429844, "2... | 22029384 | L-glutamate, the principal excitatory transmitter in the brain, gates ion channels mediating fast neurotransmission. Subunit components of two related classes of glutamate receptor channels have been characterized by cDNA cloning and shown to carry either an arginine or a glutamine residue in a defined position of thei... | RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. |
{"1011": 0.3443928062915802, "1047": 0.7314660549163818, "1055": 0.12038381397724152, "1996": 0.025073638185858727, "1997": 0.04674193635582924, "2003": 0.3588210940361023, "2011": 0.35813871026039124, "2019": 0.026025565341114998, "2024": 0.04860413447022438, "2026": 0.5151132941246033, "2029": 0.27712854743003845, "2... | 22036571 | The AMP-activated protein kinase (AMPK) is a ubiquitous mammalian protein kinase important in the adaptation of cells to metabolic stress. The enzyme is a heterotrimer, consisting of a catalytic alpha subunit and regulatory beta and gamma subunits, each of which is a member of a larger isoform family. The enzyme is all... | Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization. |
{"1014": 0.1710275560617447, "1021": 0.20501139760017395, "1054": 0.5914691090583801, "2007": 0.043007105588912964, "2011": 0.08692999184131622, "2012": 0.2667117714881897, "2038": 0.07793712615966797, "2042": 0.0797421783208847, "2043": 0.17020416259765625, "2058": 0.11778303235769272, "2062": 0.083342544734478, "2079... | 22038539 | In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA methylation at various sites. Here, we report that epigenetic drift is conserved ac... | Caloric restriction delays age-related methylation drift |
{"1011": 0.32129061222076416, "1015": 0.24018502235412598, "1050": 0.8853482007980347, "1997": 0.021256839856505394, "2000": 0.09406650811433792, "2011": 0.026025565341114998, "2015": 0.10993985831737518, "2028": 0.029824240133166313, "2029": 0.09672962874174118, "2048": 0.5751199722290039, "2064": 0.23864774405956268,... | 22042345 | Most protein complexes are inaccessible to high resolution structural analysis. We report the results of a combined approach of cross-linking, mass spectrometry, and bioinformatics to two human complexes containing large coiled-coil segments, the NDEL1 homodimer and the NDC80 heterotetramer. An important limitation of ... | Structural analysis of multiprotein complexes by cross-linking, mass spectrometry, and database searching. |
{"1011": 0.3870677351951599, "1019": 0.011650617234408855, "1043": 0.18411032855510712, "1044": 1.005902886390686, "1048": 0.7144040465354919, "1999": 0.006812678650021553, "2002": 0.18654440343379974, "2005": 0.2881702482700348, "2007": 0.28670501708984375, "2008": 0.05694137513637543, "2029": 0.32764431834220886, "20... | 22049489 | The lncRNA H19 has been recently shown to be upregulated and play important roles in gastric cancer tumorigenesis. However, the precise molecular mechanism of H19 and its mature product miR-675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that miR-675 was positively expressed with H1... | The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1. |
{"1040": 0.23710809648036957, "1044": 0.16110190749168396, "1049": 0.6583697199821472, "2003": 0.6867793202400208, "2005": 0.5562619566917419, "2024": 0.06886265426874161, "2033": 0.6684301495552063, "2044": 0.006812678650021553, "2054": 0.21214580535888672, "2064": 0.2711893916130066, "2078": 0.006812678650021553, "20... | 22057077 | Methylphenidate is a medication used routinely in the management of attention deficit hyperactivity disorder. We report a case of a prepubertal child who developed unwanted erections after commencing a response-adjusted dosing regimen of sustained release methylphenidate. Despite priapism being a rare adverse reaction ... | Methylphenidate-induced erections in a prepubertal child. |
{"1011": 0.3027053773403168, "1015": 0.16442140936851501, "1021": 0.44753631949424744, "1022": 1.1012130975723267, "1051": 1.2460440397262573, "1999": 0.7067264318466187, "2011": 0.3353555500507355, "2013": 0.10203468054533005, "2015": 0.3070250153541565, "2029": 0.16607704758644104, "2063": 0.24018502235412598, "2076"... | 22059387 | Inflammation mediated by infection is an important factor causing carcinogenesis. Opisthorchis viverrini (OV) infection is a risk factor of cholangiocarcinoma (CHCA), probably through chronic inflammation. Formation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), and expression of inducible nitric ... | Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis. |
{"1011": 0.37974658608436584, "1017": 0.055094651877880096, "1018": 0.255429208278656, "1056": 0.03831886500120163, "1177": 0.7818660736083984, "2000": 0.1808556467294693, "2004": 0.6634125709533691, "2012": 0.07341018319129944, "2025": 0.45623743534088135, "2029": 0.15442965924739838, "2035": 0.6714286804199219, "2064... | 22067786 | In an association analysis comparing cases and controls with respect to allele frequencies at a highly polymorphic locus, a potential problem is that the conventional chi-squared test may not be valid for a large, sparse contingency table. However, reliance on statistics with known asymptotic distribution is now unnece... | Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. |
{"1011": 0.09317722171545029, "1018": 0.15526613593101501, "1039": 0.018384648486971855, "1041": 0.2954642176628113, "1047": 0.7018978595733643, "1055": 0.12642613053321838, "1998": 0.0174254160374403, "1999": 0.053244512528181076, "2012": 0.6461620330810547, "2015": 0.18248429894447327, "2029": 0.2447827309370041, "20... | 22080671 | Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifying each of these cell types. Here, using Myh11-CreERT2 ROSA floxed STOP eYFP Apoe−/− mice to perfor... | KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis |
{"1011": 0.2105647772550583, "1043": 0.7710843086242676, "1051": 0.4831010699272156, "1996": 0.34715715050697327, "1999": 0.015504186972975731, "2006": 0.0317181795835495, "2007": 0.08961215615272522, "2019": 0.5404602885246277, "2029": 0.22859740257263184, "2064": 0.022212404757738113, "2072": 0.29036402702331543, "20... | 22107641 | OBJECTIVE The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression. METHOD Seventeen elderly depressed subjects were compared with 16 elderly subjects who were not depressed. Diffusion tensor imagi... | Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. |
{"1011": 0.06977381557226181, "1018": 0.03831886500120163, "1037": 0.5893046259880066, "1043": 0.4512746334075928, "1047": 0.6170841455459595, "1052": 0.27934664487838745, "1156": 0.6793810129165649, "1157": 0.33675122261047363, "2005": 0.25467249751091003, "2007": 0.0009760859538801014, "2011": 0.34023189544677734, "2... | 22116439 | Tau aggregation and amyloid β protein (Aβ) deposition are the main causes of Alzheimer's disease (AD). Peroxisome proliferator-activated receptor γ (PPARγ) activation modulates Aβ production. To test whether the PPARγ agonist pioglitazone (PIO) is also effective in preventing tau aggregation in AD, we used a cellular m... | Pioglitazone prevents tau oligomerization. |
{"1011": 0.05694137513637543, "1013": 0.2976420819759369, "1014": 0.0797421783208847, "1049": 0.1229778528213501, "1051": 0.3750596046447754, "1052": 0.083342544734478, "1058": 0.39893341064453125, "2003": 0.056018441915512085, "2051": 0.2223619967699051, "2086": 0.23092569410800934, "2090": 0.175953671336174, "2146": ... | 22123421 | BACKGROUND Mean platelet volume (MPV) is a platelet volume index. Classically, MPV was recognized as a hallmark of platelet activation. Recent studies have revealed that the MPV and MPV/platelet count (PC) ratio can predict long-term mortality in patients with ischemic cardio-vascular disease. In addition, these indice... | Prognostic impact of the mean platelet volume/platelet count ratio in terms of survival in advanced non-small cell lung cancer. |
{"1997": 0.09050461649894714, "2000": 0.052318159490823746, "2003": 0.07431721687316895, "2015": 0.45994341373443604, "2045": 0.1212492436170578, "2055": 0.011650617234408855, "2064": 0.07431721687316895, "2075": 0.2711893916130066, "2079": 0.3269403576850891, "2109": 0.05046287178993225, "2129": 0.036437395960092545, ... | 22130056 | INTRODUCTION Traceability is important in the postmarketing surveillance of biologicals, since changes in the manufacturing process may give rise to product- or batch-specific risks. With the expected expansion of the biosimilar market, there have been concerns about the ability to trace individual products within phar... | Traceability of biologicals: present challenges in pharmacovigilance. |
{"1015": 0.14179791510105133, "1047": 0.35813871026039124, "1048": 0.6327666640281677, "1050": 0.02792670577764511, "1056": 0.4412745535373688, "2005": 0.09406650811433792, "2006": 0.16524957120418549, "2008": 0.17431432008743286, "2011": 0.42608439922332764, "2015": 0.026976587250828743, "2024": 0.13414156436920166, "... | 22134353 | Natural killer (NK) cells are able to lyse infected and tumor cells while sparing healthy cells. Recognition of diseased cells by NK cells is governed by several activating and inhibitory receptors. We review numerous pathways that have been implicated in the regulation of self-ligands for activating receptors, includi... | Regulation of self-ligands for activating natural killer cell receptors. |
{"1011": 0.1011524572968483, "1018": 0.15693697333335876, "1039": 0.37974658608436584, "1041": 0.46608972549438477, "1047": 1.0298984050750732, "2005": 0.2160874605178833, "2008": 0.09850110858678818, "2015": 0.12038381397724152, "2024": 0.04860413447022438, "2026": 0.791648268699646, "2029": 0.26296505331993103, "2037... | 22150633 | Embryonic stem (ES) cells are unique in their ability to self-renew indefinitely and maintain pluripotency. These properties require transcription factors that specify the gene expression programme of ES cells. It has been possible to reverse the highly differentiated state of somatic cells back to a pluripotent state ... | A core Klf circuitry regulates self-renewal of embryonic stem cells |
{"1011": 0.1332872211933136, "1015": 0.22157983481884003, "1043": 0.5882205963134766, "1044": 0.21922965347766876, "1047": 0.9724938273429871, "2007": 0.06703783571720123, "2010": 0.0038986403960734606, "2011": 0.12814582884311676, "2012": 0.49030399322509766, "2015": 0.0752234235405922, "2026": 0.9256220459938049, "20... | 22153455 | Although gram-positive infections account for the majority of cases of sepsis, the molecular mechanisms underlying their effects remains poorly understood. We investigated how cell wall components of gram-positive bacteria contribute to the development of sepsis. Experimental observations derived from cultured primary ... | A myeloid hypoxia-inducible factor 1α-Krüppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis. |
{"1011": 0.10026945173740387, "1015": 0.06246116757392883, "1017": 0.07884006202220917, "1043": 0.36697331070899963, "1055": 0.6410312056541443, "1056": 0.21372433006763458, "1057": 0.26296505331993103, "2001": 0.02792670577764511, "2003": 0.3897167444229126, "2008": 0.12814582884311676, "2011": 0.38308101892471313, "2... | 22159299 | Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative intracellular pathogen that causes disease in a variety of hosts. S. Typhimurium actively invade host cells and typically reside within a membrane-bound compartment called the Salmonella-containing vacuole (SCV). The bacteria modify the fate of t... | Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. |
{"1009": 0.5640701055526733, "1011": 0.48670899868011475, "1015": 0.2576959431171417, "1016": 0.1064341589808464, "1017": 0.5139457583427429, "1018": 0.04674193635582924, "1020": 0.3027053773403168, "1043": 0.34370049834251404, "1047": 0.10467668622732162, "1052": 0.45251765847206116, "1055": 0.5244048833847046, "1056"... | 22174015 | The PI3K-Akt-mTORC1 axis contributes to the activation, survival, and proliferation of CD4(+) T cells upon stimulation through TCR and CD28. Here, we demonstrate that the suppression of this axis by deletion of p85α or PI3K/mTORC1 inhibitors as well as T cell-specific deletion of raptor, an essential component of mTORC... | PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ. |
{"1015": 0.38041436672210693, "1050": 0.08513788133859634, "1054": 0.009718249551951885, "2005": 0.03266380727291107, "2013": 0.500420093536377, "2026": 0.5827828645706177, "2028": 0.06703783571720123, "2029": 0.09050461649894714, "2037": 0.015504186972975731, "2049": 0.08154398202896118, "2053": 0.08064348995685577, "... | 22178316 | Schizophrenia may arise from subtle abnormalities in brain development due to alterations in the functions of candidate susceptibility genes such as Disrupted-in-schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1). To provide novel insights into the functions of DISC1 in brain development, we mapped the expression of zebra... | Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain. |
{"1011": 0.15275461971759796, "1022": 0.5557019114494324, "1050": 0.6197150945663452, "1060": 0.7163142561912537, "1998": 0.7809720039367676, "2000": 0.1751343309879303, "2007": 0.06337817758321762, "2010": 0.5795059204101562, "2013": 0.0797421783208847, "2029": 0.12986256182193756, "2046": 0.052318159490823746, "2099"... | 22180793 | The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CRPC xenografts, we found a reproducible increase in N-cadherin expression, which was also elevated in primary and metasta... | Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance |
{"1017": 0.3304552733898163, "1043": 0.3864043951034546, "1044": 0.25239890813827515, "1052": 0.3864043951034546, "2007": 0.27934664487838745, "2011": 0.27564704418182373, "2012": 0.3381449282169342, "2019": 0.417115718126297, "2029": 0.3084607720375061, "2050": 0.6043586730957031, "2076": 0.176772341132164, "2080": 0.... | 22185730 | Abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of protein phosphatase 2A (PP2A), the major tau phosphatase in human brain, contributes to tau hyperphosphorylation in AD. However, the effects of PP2A ... | PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. |
{"1011": 0.10818854719400406, "1039": 0.3127557039260864, "1044": 0.5455666780471802, "2002": 0.3903779089450836, "2003": 0.2800849378108978, "2004": 0.3304552733898163, "2008": 0.15943801403045654, "2011": 0.20022670924663544, "2013": 0.13157635927200317, "2024": 0.40871503949165344, "2046": 0.015504186972975731, "205... | 22186938 | Human artificial chromosomes (HACs) are autonomous molecules that can function and segregate as normal chromosomes in human cells. De novo HACs have successfully been used as gene expression vectors to complement genetic deficiencies in human cultured cells. HACs now offer the possibility of studying the regulation and... | Human artificial chromosomes containing chromosome 17 alphoid DNA maintain an active centromere in murine cells but are not stable. |
{"1052": 0.17431432008743286, "1996": 0.4419025182723999, "1997": 0.045809537172317505, "2003": 0.01934296265244484, "2011": 0.1384023278951645, "2043": 0.0038986403960734606, "2049": 0.4709797203540802, "2075": 0.14179791510105133, "2076": 0.009718249551951885, "2079": 0.17020416259765625, "2124": 0.055094651877880096... | 22190276 | Phagocytosis mediates the clearance of apoptotic bodies and also the elimination of microbial pathogens. The nascent phagocytic vacuole formed upon particle engulfment lacks microbicidal and degradative activity. These capabilities are acquired as the phagosome undergoes maturation; a progressive remodeling of its memb... | How nascent phagosomes mature to become phagolysosomes. |
{"1011": 0.1734936386346817, "1018": 0.012615402229130268, "1020": 0.07884006202220917, "1039": 0.3464667797088623, "1050": 0.23864774405956268, "1052": 0.25845035910606384, "1996": 0.0038986403960734606, "1997": 0.18978065252304077, "1999": 0.06429435312747955, "2002": 0.46608972549438477, "2003": 0.3903779089450836, ... | 22191759 | Cathelicidins are a novel family of antimicrobial peptide precursors from mammalian myeloid cells. They are characterized by a conserved N-terminal region while the C-terminal antimicrobial domain can vary considerably in both primary sequence and length. Four cathelicidins, proBac5, proBac7, prododecapeptide and proBM... | Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides. |
{"2001": 0.2881702482700348, "2018": 0.0038986403960734606, "2020": 0.025073638185858727, "2035": 0.39762192964553833, "2038": 0.014542185701429844, "2042": 0.42225050926208496, "2043": 0.3423145115375519, "2053": 0.07341018319129944, "2058": 0.861702561378479, "2073": 0.11168810725212097, "2075": 0.6553317308425903, "... | 22194407 | This paper seeks to establish the strength of association between contemporary tuberculosis (TB) in England and Wales and several potential aetiological factors. It presents an ecological analysis of standardised annual TB mortality rates for the 403 local authority districts between 1982 and 1992, disaggregated by age... | Tuberculosis mortality in England and Wales during 1982-1992: its association with poverty, ethnicity and AIDS. |
{"1011": 0.10291612148284912, "1016": 0.567397952079773, "1018": 0.5104349255561829, "1049": 0.8492490649223328, "1056": 0.9333322048187256, "2007": 0.2674594223499298, "2013": 0.2990913391113281, "2025": 0.036437395960092545, "2029": 0.19622190296649933, "2037": 0.12642613053321838, "2048": 0.3325583338737488, "2089":... | 22198971 | CD4 memory T cells surviving in the absence of MHC class II contact lose their characteristic memory function. To investigate the mechanisms underlying the impaired function of memory T cells in the absence of MHC class II molecules, we analyzed gene expression profiles of resting memory T cells isolated from MHC class... | Noncognate interaction with MHC class II molecules is essential for maintenance of T cell metabolism to establish optimal memory CD4 T cell function. |
{"1015": 0.7124901413917542, "1021": 0.18004031479358673, "1038": 0.6080870032310486, "1046": 0.5762182474136353, "1047": 0.5421652793884277, "1050": 0.5607312321662903, "1052": 0.12470348179340363, "1056": 1.0416836738586426, "1164": 0.3248254358768463, "1996": 0.11081436276435852, "1999": 0.06520967930555344, "2005":... | 22210434 | The kinase TAK1 is critical for innate and B cell immunity. The function of TAK1 in T cells is unclear, however. We show here that T cell–specific deletion of the gene encoding TAK1 resulted in reduced development of thymocytes, especially of regulatory T cells expressing the transcription factor Foxp3. In mature thymo... | The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function |
{"1009": 0.7638313174247742, "1011": 0.21135559678077698, "1998": 0.3409265875816345, "2007": 0.22001366317272186, "2020": 0.006812678650021553, "2029": 0.03925827145576477, "2037": 0.18329764902591705, "2058": 0.12642613053321838, "2062": 0.6970458030700684, "2084": 0.5718178153038025, "2090": 0.2969166338443756, "209... | 22227889 | This study examines factors associated with caregiver burden in 82 HIV-positive (HIV+) and 162 HIV-negative (HIV-) partners of men with AIDS. We expected HIV+ caregivers to report more burden than HIV- caregivers because of the toll of their disease on their resources. HIV+ caregivers did report more burden and, compar... | Caregiver burden in HIV-positive and HIV-negative partners of men with AIDS. |
{"1017": 0.04767346754670143, "1043": 0.5238267183303833, "1052": 0.33675122261047363, "1999": 0.0913962796330452, "2000": 0.08513788133859634, "2004": 0.3683255612850189, "2005": 0.07159364968538284, "2007": 0.33115679025650024, "2009": 0.14433705806732178, "2011": 0.15526613593101501, "2015": 0.08692999184131622, "20... | 22236223 | Pregnancy in women with different renal diseases has important consequences for the developing fetus and maternal health. Kidneys and the urinary tract have to adapt to the pregnancy status and therefore suffer significant anatomical, hemodynamic and endocrine changes. Failure to adapt can aggravate the preexisting mat... | Renal Disease and Pregnancy |
{"1011": 0.25995752215385437, "1015": 0.20739519596099854, "1017": 0.35745587944984436, "1041": 0.4950772523880005, "1043": 0.8559102416038513, "1048": 0.22704219818115234, "1156": 0.026976587250828743, "1996": 0.3683255612850189, "1999": 0.04394211992621422, "2007": 0.0009760859538801014, "2011": 0.04113444685935974, ... | 22241778 | The human kidneys filter 180 l of blood every day via about 2.5 million glomeruli. The three layers of the glomerular filtration apparatus consist of fenestrated endothelium, specialized extracellular matrix known as the glomerular basement membrane (GBM) and the podocyte foot processes with their modified adherens jun... | Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. |
{"1011": 0.10993985831737518, "1040": 0.4248080551624298, "1997": 0.034552380442619324, "1998": 0.2160874605178833, "2012": 0.24171993136405945, "2015": 0.014542185701429844, "2043": 0.20818853378295898, "2076": 0.7537717819213867, "2079": 0.07612881064414978, "2091": 0.371698260307312, "2096": 0.014542185701429844, "2... | 22264117 | During aging, the mechanisms that normally maintain health and stress resistance strikingly decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this decline occurs is unknown. Changes in transcriptional networks and chromatin state lie at the heart of age-dependent decline. These epig... | The Aging Epigenome. |
{"2000": 0.3353555500507355, "2005": 0.12642613053321838, "2038": 0.12642613053321838, "2042": 0.36358460783958435, "2062": 0.10379679501056671, "2064": 0.15860503911972046, "2079": 0.06429435312747955, "2083": 0.020300358533859253, "2109": 0.16276304423809052, "2129": 0.11604541540145874, "2139": 0.025073638185858727,... | 22267225 | Over the past three decades great efforts have been made in search of cancer chemoprevention strategies. The increase in knowledge of the long process from normal to cancer cell has enabled interventions in terms of lifestyle modifications, natural compounds or drugs to block or reverse the process. Great successes hav... | Cancer chemoprevention: Much has been done, but there is still much to do. State of the art and possible new approaches. |
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