spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
|---|---|---|---|
{"1011": 0.17431432008743286, "1017": 0.010684899985790253, "1044": 0.3956514894962311, "1045": 0.7647408246994019, "1049": 0.1510767638683319, "1052": 0.19381128251552582, "2002": 0.9761797785758972, "2004": 0.10906458646059036, "2005": 0.03266380727291107, "2011": 0.22001366317272186, "2015": 0.1734936386346817, "202... | 20033112 | Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem or progenitor cells have only been reprogrammed for the blood and neuronal lineages. We previously reported generation of induced hepatocyte-like (iHep) cells by transduction of Gata4, Hnf1α, and Fo... | Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors. |
{"1011": 0.15693697333335876, "1017": 1.0312920808792114, "1019": 0.7629209756851196, "1039": 0.23092569410800934, "1043": 0.18654440343379974, "1998": 0.2652147710323334, "1999": 0.1808556467294693, "2000": 0.014542185701429844, "2005": 0.15023678541183472, "2007": 0.129004567861557, "2008": 0.05786345899105072, "2011... | 20045514 | Although important for gene regulation, most studies of genome organization use either fluorescence in situ hybridization (FISH) or chromosome conformation capture (3C) methods. FISH directly visualizes the spatial relationship of sequences but is usually applied to a few loci at a time. The frequency at which sequence... | Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization. |
{"1011": 0.2749055027961731, "1014": 0.417115718126297, "1039": 0.3897167444229126, "1043": 0.3283478021621704, "1044": 0.3777405619621277, "1055": 0.16276304423809052, "1999": 0.09317722171545029, "2001": 0.04860413447022438, "2004": 0.5139457583427429, "2005": 0.030771657824516296, "2020": 0.12986256182193756, "2035"... | 20048431 | Objective:To describe the development of a European computerized 24-h dietary recall method for adolescents, and to investigate the feasibility of self-administration (self report) by comparison with administration by a dietician (interview).Methods:Two hundred and thirty-six adolescents (mean age 14.6 years (s.d.=1.7)... | Development and evaluation of a self-administered computerized 24-h dietary recall method for adolescents in Europe |
{"1035": 0.3916989266872406, "1043": 0.2247048318386078, "1046": 1.211173415184021, "1047": 0.4412745535373688, "1056": 0.4950772523880005, "1061": 0.040196798741817474, "2003": 0.2689530849456787, "2005": 0.09761575609445572, "2024": 0.11691460013389587, "2029": 0.07068414986133575, "2041": 0.09050461649894714, "2042"... | 20052986 | Circadian rhythms are oscillations of physiology, behavior, and metabolism that have period lengths near 24 hours. In several model organisms and humans, circadian clock genes have been characterized and found to be transcription factors. Because of this, researchers have used microarrays to characterize global regulat... | JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. |
{"1015": 0.19862671196460724, "1023": 0.6000806093215942, "1052": 0.08692999184131622, "1996": 0.1510767638683319, "2007": 0.11604541540145874, "2008": 0.083342544734478, "2011": 0.3297532796859741, "2012": 0.41065993905067444, "2015": 0.006812678650021553, "2029": 0.2983669638633728, "2043": 0.3615458607673645, "2058"... | 20054396 | In animal cells, most microtubules are nucleated at centrosomes. At the onset of mitosis, centrosomes undergo a structural reorganization, termed maturation, which leads to increased microtubule nucleation activity. Centrosome maturation is regulated by several kinases, including Polo-like kinase 1 (Plk1). Here, we ide... | Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. |
{"1011": 0.18248429894447327, "1015": 0.4624064862728119, "1039": 0.5718178153038025, "1041": 0.5080875158309937, "1042": 0.5387523174285889, "1044": 0.021256839856505394, "1999": 0.19862671196460724, "2005": 0.09850110858678818, "2007": 0.08244366943836212, "2011": 0.1677299439907074, "2025": 0.13157635927200317, "202... | 20083834 | Background/Objective:To investigate the effect of soy protein containing isoflavones on homocysteine (Hcy), C-reactive protein (CRP), soluble E-selectin (sE-selectin), soluble vascular adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1).Subject/Methods:In a randomized crossover design,... | Consumption of isoflavone-rich soy protein does not alter homocysteine or markers of inflammation in postmenopausal women |
{"1011": 0.0029254043474793434, "1051": 1.178053855895996, "1997": 0.18492233753204346, "1999": 0.06429435312747955, "2000": 0.08154398202896118, "2005": 0.19220098853111267, "2012": 0.2954642176628113, "2015": 0.23479416966438293, "2029": 0.1384023278951645, "2034": 0.5506471395492554, "2042": 0.175953671336174, "2058... | 20101846 | Earth-abundant first-row (3d) transition metal–based catalysts have been developed for the oxygen-evolution reaction (OER); however, they operate at overpotentials substantially above thermodynamic requirements. Density functional theory suggested that non-3d high-valency metals such as tungsten can modulate 3d metal o... | Homogeneously dispersed multimetal oxygen-evolving catalysts |
{"1017": 0.2394166737794876, "1018": 0.37035053968429565, "1038": 0.3923587501049042, "1039": 0.3464667797088623, "1040": 0.1011524572968483, "1051": 0.28450319170951843, "1052": 0.33953672647476196, "1997": 0.10906458646059036, "2000": 0.1619328260421753, "2001": 0.151916041970253, "2003": 0.23633737862110138, "2004":... | 20109325 | Chronic obstructive pulmonary disease (COPD) is a global health problem, and since 2001, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published its strategy document for the diagnosis and management of COPD. This executive summary presents the main contents of the second 5-year revision of the ... | Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. |
{"1017": 0.12642613053321838, "1018": 0.13670019805431366, "1019": 0.5381823778152466, "1020": 0.15275461971759796, "1021": 0.5139457583427429, "1023": 0.3547199070453644, "1039": 0.175953671336174, "1052": 0.688742995262146, "2000": 0.08513788133859634, "2007": 0.17759032547473907, "2020": 0.0009760859538801014, "2033... | 20127522 | PURPOSE Five or more circulating tumor cells (CTCs) per 7.5 mL of blood predicts for poorer progression-free survival (PFS) in patients with metastatic breast cancer (MBC). We conducted a prospective study to demonstrate that CTC results correlate strongly with radiographic disease progression at the time of and in adv... | Circulating tumor cells: a useful predictor of treatment efficacy in metastatic breast cancer. |
{"1053": 0.0797421783208847, "2011": 0.16690383851528168, "2013": 0.18004031479358673, "2015": 0.9037119746208191, "2034": 0.11430477350950241, "2043": 0.12642613053321838, "2044": 0.7836518287658691, "2064": 0.36967599391937256, "2067": 0.5376120805740356, "2075": 0.4974553883075714, "2076": 0.4450363218784332, "2089"... | 20128547 | Spinal cord injuries (SCIs) in humans and experimental animals are often associated with varying degrees of spontaneous functional recovery during the first months after injury. Such recovery is widely attributed to axons spared from injury that descend from the brain and bypass incomplete lesions, but its mechanisms a... | Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury |
{"2003": 0.13071982562541962, "2006": 0.004870930220931768, "2012": 0.34577593207359314, "2018": 0.11168810725212097, "2020": 0.05417001247406006, "2042": 0.1889725625514984, "2043": 0.0913962796330452, "2044": 0.7047978043556213, "2046": 0.21922965347766876, "2051": 0.05046287178993225, "2053": 0.02792670577764511, "2... | 20130904 | BACKGROUND Gastric bypass patients with a range of disturbed eating patterns before surgery may be at risk of returning to old patterns postoperatively. Recent research has shown that binge eating is common among the obese before surgery as well as in the postoperative maintenance phase and appears to be linked to poor... | "Grazing": a high-risk behavior. |
{"1011": 0.00875066313892603, "1039": 0.3824150264263153, "1044": 0.6502478122711182, "1050": 0.2607102394104004, "1058": 0.0058422754518687725, "1997": 0.04487626627087593, "2003": 0.03266380727291107, "2005": 0.083342544734478, "2008": 0.014542185701429844, "2013": 0.3499138653278351, "2015": 0.4177590310573578, "202... | 20132778 | Gene-encoded antimicrobial peptides that protect the skin of hylid and ranin frogs against noxious microorganisms are processed from a unique family of precursor polypeptides with a unique pattern of conserved and variable regions opposite to that of conventional secreted peptides. Precursors belonging to this family, ... | Molecular strategies in biological evolution of antimicrobial peptides. |
{"1016": 0.5930894017219543, "1040": 0.49982786178588867, "1041": 0.2531573474407196, "1056": 0.9363996982574463, "2005": 0.10906458646059036, "2007": 0.19541899859905243, "2011": 0.31489628553390503, "2015": 0.48430517315864563, "2029": 0.13755162060260773, "2031": 0.04674193635582924, "2035": 0.25995752215385437, "20... | 20148808 | The mammalian gastrointestinal tract harbors a microbial community with metabolic activity critical for host health, including metabolites that can modulate effector functions of immune cells. Mice treated with vancomycin have an altered microbiome and metabolite profile, exhibit exacerbated T helper type 2 cell (Th2) ... | Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids |
{"1011": 0.055094651877880096, "1056": 1.1018621921539307, "1996": 0.32764431834220886, "1999": 0.05970508232712746, "2004": 0.020300358533859253, "2008": 0.08961215615272522, "2015": 0.26446542143821716, "2029": 0.2409527748823166, "2035": 0.02887592278420925, "2038": 0.06703783571720123, "2076": 0.2637155055999756, "... | 20155713 | Expression of peripheral antigens in the thymus has been implicated in T cell tolerance and autoimmunity. Here we identified medullary thymic epithelial cells as being a unique cell type that expresses a diverse range of tissue-specific antigens. We found that this promiscuous gene expression was a cell-autonomous prop... | Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self |
{"1011": 0.1970241367816925, "1017": 0.6512666940689087, "1018": 0.28597161173820496, "1997": 0.1332872211933136, "1998": 0.33605360984802246, "2005": 0.03266380727291107, "2007": 0.36426326632499695, "2008": 0.0174254160374403, "2011": 0.00875066313892603, "2012": 0.4412745535373688, "2029": 0.4196864068508148, "2039"... | 20179918 | Both signal transducer and activator of transcription 3 (STAT3) and SALL4 are important in maintaining the pluripotent and self-renewal state of embryonic stem cells. We hypothesized that STAT3, a latent transcriptional factor, may regulate the gene expression of SALL4. In support of this hypothesis, DNA sequence analy... | Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4. |
{"1011": 0.09761575609445572, "1017": 0.07612881064414978, "1018": 0.3127557039260864, "1043": 0.29109421372413635, "1050": 0.37974658608436584, "1056": 1.059443712234497, "1156": 0.9485763907432556, "2003": 0.1602703034877777, "2011": 0.03925827145576477, "2029": 0.1889725625514984, "2033": 0.5882205963134766, "2058":... | 20183360 | Transforming growth factor β (TGFβ) is a potent and context-dependent regulator of tumor progression. TGFβ promotes the lung metastasis of basal-like (but not the luminal-like) breast cancer. Here, we demonstrated that fascin, a pro-metastasis actin bundling protein, was a direct target of the canonical TGFβ-Smad4 sign... | GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion. |
{"1011": 0.17759032547473907, "1017": 0.14433705806732178, "1018": 0.3297532796859741, "1019": 0.011650617234408855, "1020": 0.15359249711036682, "1021": 0.3656192123889923, "1054": 1.0430610179901123, "1997": 0.06703783571720123, "2000": 0.05970508232712746, "2004": 0.20580662786960602, "2005": 0.25694093108177185, "2... | 20186513 | The revised criteria for the classification of rheumatoid arthritis (RA) were formulated from a computerized analysis of 262 contemporary, consecutively studied patients with RA and 262 control subjects with rheumatic diseases other than RA (non-RA). The new criteria are as follows: 1) morning stiffness in and around j... | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. |
{"1040": 0.3346569836139679, "2003": 0.07250232994556427, "2005": 0.1718502640724182, "2013": 0.49626702070236206, "2024": 0.16607704758644104, "2026": 0.7067264318466187, "2034": 0.13670019805431366, "2038": 0.004870930220931768, "2064": 0.13499516248703003, "2079": 0.3191637098789215, "2089": 0.14095009863376617, "21... | 20186814 | Muscle satellite cells have long been considered a distinct myogenic lineage responsible for postnatal growth, repair, and maintenance of skeletal muscle. Recent studies in mice, however, have revealed the potential for highly purified hematopoietic stem cells from bone marrow to participate in muscle regeneration. Per... | A new look at the origin, function, and "stem-cell" status of muscle satellite cells. |
{"1011": 0.01934296265244484, "1013": 0.06429435312747955, "1037": 0.09228714555501938, "1998": 0.35813871026039124, "2007": 0.1677299439907074, "2024": 0.037378571927547455, "2037": 0.10467668622732162, "2040": 0.12384103983640671, "2054": 0.4190443754196167, "2068": 0.06154331564903259, "2079": 0.12986256182193756, "... | 20187433 | Family members are an integral part of a patient's cancer care from the moment the diagnosis is delivered to the conclusion of treatment. Family members bring with them a range of emotional reactions, interpersonal dynamics and expectations for the care the patient receives. This study is part of a multi-institutional ... | Involving family members in cancer care: focus group considerations of patients and oncological providers. |
{"1003": 0.27044451236724854, "1014": 0.2447827309370041, "1019": 0.020300358533859253, "1023": 0.026025565341114998, "1052": 0.32270604372024536, "1062": 0.013579257763922215, "1609": 0.06977381557226181, "2000": 0.07884006202220917, "2001": 0.03831886500120163, "2044": 0.06795065850019455, "2051": 0.8074519634246826,... | 20188586 | BACKGROUND Real-time adherence monitoring is now possible through medication storage devices equipped with cellular technology. We assessed the effect of triggered cell phone reminders and counseling using objective adherence data on antiretroviral therapy (ART) adherence among Chinese HIV-infected patients. METHODS We... | Improving Adherence to Antiretroviral Therapy With Triggered Real-time Text Message Reminders: The China Adherence Through Technology Study. |
{"1006": 0.021256839856505394, "1007": 0.034552380442619324, "1009": 0.7960633039474487, "1011": 0.36697331070899963, "1017": 0.42353010177612305, "1018": 0.1718502640724182, "1056": 0.9432673454284668, "1998": 0.2160874605178833, "2006": 0.04953393340110779, "2007": 0.0752234235405922, "2008": 0.09050461649894714, "20... | 20220731 | Foxp3(+)CD4(+)CD25(+) regulatory T cells can differentiate from Foxp3(-)CD4(+) medullary thymocytes and Foxp3(-)CD4(+) naive T cells. However, the impact of these two processes on size and composition of the peripheral repertoire of regulatory T cells is unclear. Here we followed the fate of individual Foxp3(+)CD4(+)CD... | Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. |
{"1014": 0.49030399322509766, "1017": 0.2607102394104004, "1020": 0.010684899985790253, "1041": 0.014542185701429844, "1043": 0.8013357520103455, "1044": 0.17840765416622162, "1045": 0.0606246218085289, "1164": 0.3601844012737274, "2000": 0.009718249551951885, "2003": 0.4624064862728119, "2005": 0.010684899985790253, "... | 20221907 | BACKGROUND Most gynecologists determine therapy based on current International Society of Gynecologic Pathologists (ISGP)/World Health Organization classification of endometrial hyperplasia, the reproducibility of which has been questioned. The Gynecologic Oncology Group (GOG) initiated a protocol to assess the efficac... | Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. |
{"1011": 0.0606246218085289, "1017": 0.1485546976327896, "1047": 0.49626702070236206, "1052": 0.04207121208310127, "1057": 0.7863243818283081, "1062": 1.0735615491867065, "2004": 0.07341018319129944, "2007": 0.036437395960092545, "2011": 0.2837681770324707, "2029": 0.2409527748823166, "2075": 0.5882205963134766, "2076"... | 20231138 | DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis, polyubiquitination activates an error-free pathway, elusive in mammals, enabling damage bypass by template switching. Fork reversal is driven in vitro by multipl... | Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity |
{"1014": 0.12038381397724152, "1017": 0.026025565341114998, "1019": 0.0038986403960734606, "1042": 0.015504186972975731, "1999": 0.18816383183002472, "2004": 0.053244512528181076, "2006": 0.056018441915512085, "2007": 0.5393219590187073, "2015": 0.6512666940689087, "2025": 0.15610189735889435, "2035": 0.045809537172317... | 20240998 | OBJECTIVE To resolve uncertainty as to the risk of Sudden Infant Death Syndrome (SIDS) associated with sleeping in bed with your baby if neither parent smokes and the baby is breastfed. DESIGN Bed sharing was defined as sleeping with a baby in the parents' bed; room sharing as baby sleeping in the parents' room. Freque... | Bed sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case–control studies |
{"1011": 0.2026219218969345, "1019": 0.09672962874174118, "1038": 0.9798521995544434, "1039": 0.045809537172317505, "2006": 0.09495500475168228, "2019": 0.31489628553390503, "2039": 0.6902132034301758, "2048": 0.24171993136405945, "2066": 0.11081436276435852, "2076": 0.3662964701652527, "2109": 0.28963330388069153, "21... | 20261352 | OBJECTIVE To define the impact of chronic viremia and associated immune activation on B-cell exhaustion in HIV infection. DESIGN Progressive HIV infection is marked by B-cell anergy and exhaustion coupled with dramatic hypergammaglobulinemia. Although both upregulation of CD95 and loss of CD21 have been used as markers... | Decoupling activation and exhaustion of B cells in spontaneous controllers of HIV infection. |
{"1004": 0.22937409579753876, "1011": 0.34922540187835693, "1017": 0.02887592278420925, "1054": 0.2711893916130066, "1055": 0.0029254043474793434, "1060": 0.06337817758321762, "2002": 0.2741633653640747, "2003": 0.40220460295677185, "2005": 0.15777134895324707, "2010": 0.7755908370018005, "2013": 0.0770333781838417, "2... | 20279166 | Label-free DNA imaging is highly desirable in biology and medicine to perform live imaging without affecting cell function and to obtain instant histological tissue examination during surgical procedures. Here we show a label-free DNA imaging method with stimulated Raman scattering (SRS) microscopy for visualization of... | Label-free DNA imaging in vivo with stimulated Raman scattering microscopy. |
{"1014": 0.06154331564903259, "1016": 0.3134697377681732, "1044": 0.2983669638633728, "1050": 0.18654440343379974, "2029": 0.11691460013389587, "2035": 0.23402166366577148, "2050": 0.1734936386346817, "2078": 0.17431432008743286, "2079": 0.04860413447022438, "2084": 0.2034190446138382, "2101": 0.02887592278420925, "211... | 20280410 | Inherited mutations in the gene BRCA2 predispose carriers to early onset breast cancer, but such mutations account for fewer than 2% of all cases in East Anglia. It is likely that low penetrance alleles explain the greater part of inherited susceptibility to breast cancer; polymorphic variants in strongly predisposing ... | A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability |
{"1011": 0.08871890604496002, "1039": 0.3547199070453644, "1041": 1.1018621921539307, "1043": 0.43623676896095276, "1051": 0.5336109399795532, "1053": 0.09850110858678818, "1056": 0.8633513450622559, "1057": 1.094698429107666, "2003": 0.495672345161438, "2006": 0.371698260307312, "2011": 0.1221139207482338, "2012": 0.4... | 20287253 | Congenital obstructive nephropathy is a consequence abnormal urinary tract development resulting in renal growth failure and injury manifested by progressive tubular atrophy and interstitial fibrosis. We have studied the renal cellular and physiological response to unilateral ureteral obstruction (UUO) in the neonatal ... | Pathophysiology of obstructive nephropathy in the newborn. |
{"1055": 0.0038986403960734606, "1057": 0.17020416259765625, "1997": 0.037378571927547455, "2004": 0.05694137513637543, "2015": 0.4450363218784332, "2038": 0.02887592278420925, "2042": 0.014542185701429844, "2058": 0.7638313174247742, "2063": 0.030771657824516296, "2064": 0.14349138736724854, "2075": 0.5483922958374023... | 20288322 | In the 20th century industrialized nations have become afflicted with an unprecedented pandemic of increased adiposity. In the United States, the epicenter of the epidemic, over 2/3 of the population, is overweight and 1 of every 6 Americans carries the diagnosis of metabolic syndrome. Although genes determine suscepti... | Lipid homeostasis, lipotoxicity and the metabolic syndrome. |
{"1011": 0.2881702482700348, "1014": 0.49864232540130615, "1040": 0.5925496220588684, "1041": 0.1510767638683319, "1049": 0.630689799785614, "1062": 0.0770333781838417, "1998": 0.3683255612850189, "2007": 0.1946154683828354, "2014": 0.8731874823570251, "2015": 0.5925496220588684, "2026": 0.05694137513637543, "2033": 1.... | 20302714 | Circadian rhythms are associated with the preference for sleep-wake timing, also known as morningness-eveningness (ME). Both circadian rhythms and ME are influenced by genetic factors. Studies show an association between eveningness and depression. This study investigates the heritability of ME and whether ME and depre... | A twin-study of genetic contributions to morningness-eveningness and depression. |
{"1009": 0.5139457583427429, "1011": 0.5295937061309814, "1021": 0.7969439625740051, "1035": 0.006812678650021553, "1048": 0.3588210940361023, "1056": 0.9783848524093628, "1155": 0.7067264318466187, "2002": 0.5517725944519043, "2007": 0.021256839856505394, "2011": 0.4818955361843109, "2012": 0.4437839686870575, "2029":... | 20310709 | Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent colitis. Here, we show that interleukin-17A (IL-17A)-producing IL-7Rα(+) innate lymphoid cells (ILCs) were potent promoters of disease in Tbx21(-/-)Rag2(-/-) ulcerative colitis (TRUC) mice. TNF-α produced by CD103(-)CD1... | The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells |
{"1011": 0.16359257698059082, "1041": 0.011650617234408855, "1045": 0.5162794589996338, "1048": 0.15275461971759796, "1056": 1.1255888938903809, "2005": 0.3824150264263153, "2007": 0.052318159490823746, "2011": 0.09761575609445572, "2029": 0.14518201351165771, "2035": 0.5957841277122498, "2038": 0.0058422754518687725, ... | 20311968 | Cellular therapy with chimeric antigen receptor (CAR)-redirected cytotoxic T cells has shown impressive efficacy in the treatment of hematologic malignancies. We explored a regulatory T cell (Treg)-based therapy in the treatment of allergic airway inflammation, a model for asthma, which is characterized by an airway hy... | Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma |
{"1011": 0.37304413318634033, "1155": 0.952351450920105, "1996": 0.11517547070980072, "1999": 0.0174254160374403, "2004": 0.14939609169960022, "2005": 0.05970508232712746, "2008": 0.05139094591140747, "2011": 0.4374985992908478, "2015": 0.8306987881660461, "2029": 0.1970241367816925, "2046": 0.2034190446138382, "2076":... | 20313748 | Adherens junctions (AJs), which are organized by adhesion proteins and the underlying actin cytoskeleton, probably sense pulling forces from adjacent cells and modulate opposing forces to maintain tissue integrity, but the regulatory mechanism remains unknown at the molecular level. Although the possibility that α-cate... | α-Catenin as a tension transducer that induces adherens junction development |
{"1055": 0.0770333781838417, "1062": 0.28743788599967957, "1998": 0.3353555500507355, "2004": 0.15526613593101501, "2007": 0.26446542143821716, "2012": 0.23864774405956268, "2042": 0.07612881064414978, "2044": 0.37304413318634033, "2048": 0.0797421783208847, "2051": 0.15359249711036682, "2058": 0.04674193635582924, "20... | 20321154 | BACKGROUND The bidirectional relationships between metabolic syndrome (MetS) and schizophrenia (SCZ) play a crucial role in clinical treatment of both diseases but such bidirectional causal effects have not been comprehensively elucidated. AIMS To investigate the influence of MetS on incident SCZ and the opposite direc... | A population-based cohort study to elucidate temporal relationship between schizophrenia and metabolic syndrome (KCIS no. PSY3). |
{"1019": 0.4914994537830353, "1020": 0.3170322775840759, "1038": 0.20977331697940826, "1040": 0.1011524572968483, "1041": 0.36697331070899963, "1042": 0.43244171142578125, "2001": 0.07884006202220917, "2020": 0.09672962874174118, "2029": 0.04394211992621422, "2040": 0.3070250153541565, "2084": 0.13670019805431366, "210... | 20326526 | This series of studies describes the development of a measure of emotional intelligence based on the model of emotional intelligence developed by Salovey and Mayer [Salovey, P. & Mayer, J. D. (1990). Emotional intelligence. Imagination, Cognition and Personality, 9, 185–211.]. A pool of 62 items represented the differe... | DEVELOPMENT AND VALIDATION OF A MEASURE OF EMOTIONAL INTELLIGENCE |
{"1011": 0.05786345899105072, "1015": 0.010684899985790253, "1043": 0.5313173532485962, "1044": 0.947819709777832, "1048": 0.026976587250828743, "1052": 0.9568626880645752, "1056": 0.8374842405319214, "1155": 0.6011518239974976, "1999": 0.02792670577764511, "2002": 0.8699195384979248, "2004": 0.07341018319129944, "2011... | 20330519 | Helicobacter pylori infection causes gastric pathology such as ulcer and carcinoma. Because H. pylori is auxotrophic for cholesterol, we have explored the assimilation of cholesterol by H. pylori in infection. Here we show that H. pylori follows a cholesterol gradient and extracts the lipid from plasma membranes of epi... | Cholesterol glucosylation promotes immune evasion by Helicobacter pylori |
{"1052": 0.1602703034877777, "1056": 0.3897167444229126, "1998": 0.22704219818115234, "1999": 0.2969166338443756, "2000": 0.02887592278420925, "2003": 0.09317722171545029, "2007": 0.08244366943836212, "2011": 0.23092569410800934, "2026": 1.0051883459091187, "2029": 0.24554696679115295, "2033": 0.043007105588912964, "20... | 20333864 | The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors. Progression to invasion ... | Regulation of in situ to invasive breast carcinoma transition. |
{"2013": 0.03925827145576477, "2015": 0.022212404757738113, "2020": 0.11081436276435852, "2027": 0.026025565341114998, "2037": 0.417115718126297, "2055": 0.2689530849456787, "2071": 0.010684899985790253, "2073": 0.2105647772550583, "2079": 0.06703783571720123, "2087": 0.23247487843036652, "2092": 0.14095009863376617, "... | 20334484 | Homeless youth suffer from high rates of health problems, yet little is known about their perceptions of or context for their own health issues. In this study, a combination of qualitative techniques from participatory rural appraisal and rapid assessment procedures was used to investigate the perceptions of health nee... | Health and access to care: perspectives of homeless youth in Baltimore City, U.S.A. |
{"1009": 0.19381128251552582, "1011": 0.3084607720375061, "1015": 0.5914691090583801, "1020": 0.16524957120418549, "1022": 0.18411032855510712, "1050": 0.6793810129165649, "1056": 0.8666408061981201, "1164": 0.006812678650021553, "1999": 0.04487626627087593, "2005": 0.12986256182193756, "2011": 0.3464667797088623, "201... | 20344442 | Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg,... | Differential requirement for CARMA1 in agonist-selected T-cell development. |
{"1009": 0.13157635927200317, "1020": 0.11343330889940262, "1039": 0.8450632095336914, "1050": 0.20977331697940826, "1052": 0.53589928150177, "1057": 0.6022219061851501, "1058": 0.036437395960092545, "2004": 0.15693697333335876, "2005": 0.2976420819759369, "2008": 0.1677299439907074, "2011": 0.2493593990802765, "2013":... | 20357868 | Primary simian immunodeficiency virus (SIV) isolated from sooty mangabey (SIVsm [n = 6]), stumptail (SIVstm [n = 1]), mandrill (SIVmnd [n = 1]), and African green (SIVagm [n = 1]) primates were examined for their ability to infect human cells and for their coreceptor requirements. All isolates infected human peripheral... | Simian immunodeficiency viruses of diverse origin can use CXCR4 as a coreceptor for entry into human cells. |
{"1011": 0.2990913391113281, "1015": 0.06429435312747955, "1016": 0.1384023278951645, "1017": 0.28743788599967957, "1020": 0.12814582884311676, "1057": 0.030771657824516296, "1997": 0.013579257763922215, "1999": 0.27712854743003845, "2007": 0.3084607720375061, "2013": 0.5517725944519043, "2020": 0.03925827145576477, "2... | 20363389 | In order to elucidate energy balance in the skeletal muscle, we cloned cDNA of a homologue of uncoupling protein (UCP) from rat skeletal muscle. We also cloned rat UCP-2 cDNA from rat brown adipose tissue (BAT). The UCP cloned from rat skeletal muscle showed 57% and 72% identity with rat UCP-1 and UCP-2. The mRNA was e... | Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet. |
{"1011": 0.40285754203796387, "1017": 0.0029254043474793434, "1037": 0.5573811531066895, "1038": 0.43434104323387146, "1039": 0.29109421372413635, "1044": 0.7248653769493103, "1996": 0.36290550231933594, "1997": 0.07068414986133575, "1999": 0.0174254160374403, "2002": 0.021256839856505394, "2005": 0.11604541540145874, ... | 20368353 | The basic determinant of chromosome inheritance, the centromere, is specified in many eukaryotes by an epigenetic mark. Using gene targeting in human cells and fission yeast, chromatin containing the centromere-specific histone H3 variant CENP-A is demonstrated to be the epigenetic mark that acts through a two-step mec... | A two-step mechanism for epigenetic specification of centromere identity and function |
{"1039": 0.7276995778083801, "1041": 0.040196798741817474, "2003": 0.08961215615272522, "2047": 0.08513788133859634, "2061": 0.3656192123889923, "2064": 0.0058422754518687725, "2071": 0.07341018319129944, "2109": 0.04860413447022438, "2114": 0.12384103983640671, "2124": 0.007782140281051397, "2170": 0.5324648022651672,... | 20372201 | A growing body of evidence supports the notion that malignant tumors are heterogeneous and contain diverse subpopulations of cells with unique characteristics including the ability to initiate a tumor and metastasize. This phenomenon might be explained by the so-called cancer stem cell (CSC) theory. Recent technologica... | Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges |
{"1011": 0.3163207769393921, "1017": 0.5057345628738403, "1018": 0.3241194784641266, "1019": 0.12814582884311676, "1043": 0.5947071313858032, "1046": 0.09228714555501938, "1047": 0.4518963396549225, "1054": 0.1485546976327896, "1997": 0.09938567131757736, "1999": 0.1873544454574585, "2005": 0.014542185701429844, "2011"... | 20374609 | We analyzed the in vitro splicing pathways of three multi-intervening-sequence (IVS) pre-mRNAs: human beta-globin, which contains two IVSs (K. M. Lang, V. L. van Santen, and R. A. Spritz, EMBO J. 4:1991-1996, 1985); rat alpha-lactalbumin, which contains three IVSs; and murine interleukin-3, which contains four IVSs. We... | In vitro splicing pathways of pre-mRNAs containing multiple intervening sequences? |
{"1019": 0.07431721687316895, "1041": 0.27712854743003845, "1043": 0.5876781344413757, "1062": 0.16442140936851501, "2000": 0.08154398202896118, "2003": 0.10379679501056671, "2013": 0.04207121208310127, "2015": 0.17431432008743286, "2047": 0.03925827145576477, "2064": 0.07884006202220917, "2079": 0.23710809648036957, "... | 20375264 | MOTIVATION Large-scale genome projects generate a rapidly increasing number of sequences, most of them biochemically uncharacterized. Research in bioinformatics contributes to the development of methods for the computational characterization of these sequences. However, the installation and application of these methods... | Automated genome sequence analysis and annotation. |
{"1011": 0.3346569836139679, "1016": 0.12556517124176025, "1017": 0.009718249551951885, "1043": 0.26296505331993103, "1050": 0.5461324453353882, "1052": 0.5336109399795532, "1055": 0.9363996982574463, "1997": 0.006812678650021553, "1999": 0.3141832649707794, "2003": 0.259204238653183, "2004": 0.09317722171545029, "2010... | 20381484 | S-nitrosylation of proteins by nitric oxide is a major mode of signalling in cells. S-nitrosylation can mediate the regulation of a range of proteins, including prominent nuclear proteins, such as HDAC2 (ref. 2) and PARP1 (ref. 3). The high reactivity of the nitric oxide group with protein thiols, but the selective nat... | GAPDH Mediates Nitrosylation of Nuclear Proteins |
{"1009": 0.4203280806541443, "1011": 0.4818955361843109, "1018": 0.9379299283027649, "1039": 0.8633513450622559, "1045": 0.4891071021556854, "1056": 0.7163142561912537, "1999": 0.0842406153678894, "2008": 0.056018441915512085, "2011": 0.10906458646059036, "2029": 0.38441169261932373, "2038": 0.06520967930555344, "2046"... | 20388894 | IL-4 promotes the differentiation of naive CD4+ T cells into IL-4-producing T helper 2 (Th2) cells. Previous work provided suggestive but not conclusive evidence that the transcription factor c-Maf directed the tissue-specific expression of IL-4. It was not known whether c-Maf controlled the transcription of other Th2 ... | The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. |
{"1011": 0.11430477350950241, "1039": 1.0101795196533203, "1043": 0.4132472574710846, "1044": 0.5903874635696411, "1050": 0.6456501483917236, "1052": 0.4734157919883728, "1054": 0.0606246218085289, "1055": 0.6548244953155518, "1155": 0.4818955361843109, "1999": 0.03266380727291107, "2002": 1.2633098363876343, "2005": 0... | 20399078 | The recommended treatment for patients with chronic hepatitis C, pegylated interferon-α (PEG-IFN-α) plus ribavirin (RBV), does not provide sustained virologic response (SVR) in all patients. We report a genome-wide association study (GWAS) to null virological response (NVR) in the treatment of patients with hepatitis C... | Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C |
{"1011": 0.14264501631259918, "1061": 0.05417001247406006, "1996": 0.04487626627087593, "2008": 0.13925230503082275, "2011": 0.27044451236724854, "2012": 0.08603433519601822, "2029": 0.27786844968795776, "2030": 0.7258110046386719, "2043": 0.08513788133859634, "2046": 0.176772341132164, "2058": 0.5979346632957458, "207... | 20402596 | In rice (Oryza sativa), the shoot-borne crown roots are the major root type and are initiated at lower stem nodes as part of normal plant development. However, the regulatory mechanism of crown root development is poorly understood. In this work, we show that a WUSCHEL-related Homeobox (WOX) gene, WOX11, is involved in... | The WUSCHEL-related homeobox gene WOX11 is required to activate shoot-borne crown root development in rice. |
{"2003": 0.05417001247406006, "2025": 0.036437395960092545, "2037": 0.20977331697940826, "2043": 0.013579257763922215, "2044": 0.0354953333735466, "2076": 0.6853039860725403, "2089": 0.10291612148284912, "2096": 0.07250232994556427, "2106": 0.23479416966438293, "2139": 0.15777134895324707, "2158": 0.022212404757738113,... | 20418809 | A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which are endogenous muscle stem cells, and impaired muscle regenerative capac... | Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia |
{"1041": 0.011650617234408855, "2045": 0.13414156436920166, "2050": 0.05417001247406006, "2055": 0.06246116757392883, "2061": 0.29619070887565613, "2064": 0.009718249551951885, "2071": 0.0913962796330452, "2089": 0.15610189735889435, "2105": 0.39367714524269104, "2179": 0.04953393340110779, "2195": 0.03266380727291107,... | 20419913 | The debate around the frequency and importance of genetic exchange in parasitic protozoa is now several decades old. Recently, fresh assertions have been made that predominant clonal evolution explains the population structures of several key protozoan pathogens. Here, we present an alternative perspective. On the assu... | Reproductive clonality in protozoan pathogens--truth or artefact? |
{"1011": 0.2837681770324707, "1015": 0.03360854089260101, "1038": 0.2478361576795578, "1055": 0.5197699069976807, "1060": 0.3784096837043762, "2004": 0.04953393340110779, "2005": 0.24401791393756866, "2007": 0.18492233753204346, "2011": 0.37640097737312317, "2012": 0.472198486328125, "2029": 0.23015019297599792, "2043"... | 20420780 | DNA double-strand breaks (DSBs) are repaired via nonhomologous end-joining (NHEJ) or homologous recombination (HR), but cellular repair processes remain elusive. We show here that the ATP-dependent chromatin-remodeling factors, ACF1 and SNF2H, accumulate rapidly at DSBs and are required for DSB repair in human cells. I... | The ACF1 complex is required for DNA double-strand break repair in human cells. |
{"1011": 0.17840765416622162, "1017": 0.4158279001712799, "1041": 0.40806588530540466, "1044": 0.08244366943836212, "1048": 0.9754437208175659, "1050": 0.23710809648036957, "1057": 0.17020416259765625, "2001": 0.10818854719400406, "2002": 0.04394211992621422, "2004": 1.1185935735702515, "2005": 0.19622190296649933, "20... | 20422174 | Controversy exists in the United States regarding the proper evaluation and management of low-grade squamous intraepithelial lesion (LSIL) and equivocal (atypical squamous cells of undetermined significance [ASCUS, now ASC-US]) cervical cytologic interpretations. To address this issue, the National Cancer Institute ini... | Findings to date from the ASCUS-LSIL Triage Study (ALTS). |
{"1039": 0.5957841277122498, "1048": 0.10203468054533005, "1999": 0.07431721687316895, "2005": 0.43053874373435974, "2013": 0.6639154553413391, "2024": 0.2184450328350067, "2029": 0.0606246218085289, "2034": 0.4980490207672119, "2038": 0.10291612148284912, "2050": 0.3870677351951599, "2073": 0.09850110858678818, "2079"... | 20428155 | Various active anticancer agents are derived from plants and terrestrial microorganisms. The isolation of C-nucleosides from the Caribbean sponge, Cryptotheca crypta, four decades ago, provided the basis for the synthesis of cytarabine, the first marine-derived anticancer agent to be developed for clinical use. Cytarab... | Marine organisms as a source of new anticancer agents. |
{"1011": 0.1970241367816925, "1017": 0.1358480453491211, "1018": 0.08692999184131622, "1043": 0.0842406153678894, "1081": 0.6317287683486938, "1999": 0.3191637098789215, "2007": 0.3683255612850189, "2011": 0.029824240133166313, "2012": 0.2447827309370041, "2029": 0.10026945173740387, "2038": 0.04394211992621422, "2078"... | 20454006 | Diindolylmethane (DIM), a bioactive metabolite of indole-3-carbinol found in cruciferous vegetables, has proposed cancer chemoprevention activity in the breast. There is limited evidence of clinically relevant activity of DIM or long-term safety data of its regular use. A randomized, double-blind, placebo-controlled tr... | A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen |
{"1042": 0.3019835948944092, "1996": 0.009718249551951885, "1998": 0.13071982562541962, "1999": 0.02316705882549286, "2004": 0.12986256182193756, "2005": 0.176772341132164, "2019": 0.42735910415649414, "2029": 0.22157983481884003, "2064": 0.1946154683828354, "2078": 0.13243216276168823, "2079": 0.34922540187835693, "20... | 20456030 | Mitochondria play a pivotal role in energy metabolism, programmed cell death and oxidative stress. Mutated mitochondrial DNA in diseased cells compromises the structure of key enzyme complexes and, therefore, mitochondrial function, which leads to a myriad of health-related conditions such as cancer, neurodegenerative ... | Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies. |
{"1006": 0.1970241367816925, "1009": 0.817850649356842, "1011": 0.3910386264324188, "1017": 0.23402166366577148, "1018": 0.11517547070980072, "1022": 0.7163142561912537, "1039": 0.015504186972975731, "1043": 0.3743882179260254, "1048": 0.43244171142578125, "1054": 0.6000806093215942, "1056": 0.8869584798812866, "1999":... | 20457190 | We have reported the existence of biochemical and conformational differences in the alphabeta T cell receptor (TCR) complex between CD4(+) and CD8(+) CD3gamma-deficient (gamma(-)) mature T cells. In the present study, we have furthered our understanding and extended the observations to primary T lymphocytes from normal... | Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes. |
{"1050": 0.0606246218085289, "1052": 0.04767346754670143, "1999": 0.004870930220931768, "2003": 0.05694137513637543, "2005": 0.13925230503082275, "2007": 0.4974553883075714, "2029": 0.14602625370025635, "2051": 0.38041436672210693, "2076": 0.5220900774002075, "2099": 0.6719275116920471, "2109": 0.3077431619167328, "212... | 20459964 | Neutrophil is a key cell in pathophysiology of granulomatosis with polyangiitis. Recently, neutrophil extracellular traps were described in this disease. Mitochondrial DNA is also released during traps formation. We measured circulating cell-free mitochondrial and genomic DNA in serum of patients with granulomatosis wi... | Circulating mitochondrial DNA in serum of patients with granulomatosis with polyangiitis. |
{"1011": 0.11430477350950241, "2005": 0.20580662786960602, "2015": 0.22001366317272186, "2029": 0.18411032855510712, "2076": 0.18004031479358673, "2079": 0.15777134895324707, "2135": 0.029824240133166313, "2174": 0.004870930220931768, "2265": 0.05694137513637543, "2334": 1.0101795196533203, "2339": 0.1011524572968483, ... | 20460020 | Efficient local monocyte/macrophage recruitment is critical for tissue repair. Recruited macrophages are polarized toward classical (proinflammatory) or alternative (prohealing) activation in response to cytokines, with tight temporal regulation crucial for efficient wound repair. Estrogen acts as a potent anti-inflamm... | Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair. |
{"100": 0.3897167444229126, "1011": 0.2983669638633728, "1013": 0.1384023278951645, "1039": 0.12038381397724152, "1040": 0.22704219818115234, "1998": 0.00875066313892603, "1999": 0.10993985831737518, "2006": 0.15442965924739838, "2007": 0.19622190296649933, "2012": 0.1693800985813141, "2015": 0.03266380727291107, "2029... | 20471181 | Despite widespread use of antiretroviral therapies to control replication of the human immunodeficiency virus (HIV), dysfunctions of cognition that are collectively termed HIV-associated neurocognitive disorders (HAND) still occur in approximately 50% of those infected by the virus. Currently there is not a biomarker t... | Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus |
{"1014": 0.2516399025917053, "1040": 0.07068414986133575, "1048": 0.02316705882549286, "1052": 0.3883931338787079, "2001": 0.04113444685935974, "2051": 0.4855078160762787, "2058": 0.08692999184131622, "2076": 0.5051454305648804, "2090": 0.1677299439907074, "2099": 0.09406650811433792, "2102": 0.17759032547473907, "2109... | 20473074 | OBJECTIVE To examine associations between mean daily fluid balance during intensive care unit study enrollment and clinical outcomes in patients enrolled in the Randomized Evaluation of Normal vs. Augmented Level (RENAL) replacement therapy study. DESIGN Statistical analysis of data from multicenter, randomized, contro... | An observational study fluid balance and patient outcomes in the Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy trial. |
{"2005": 0.2447827309370041, "2031": 0.09584271162748337, "2038": 0.026976587250828743, "2054": 0.15943801403045654, "2055": 0.06703783571720123, "2070": 0.011650617234408855, "2079": 0.10818854719400406, "2108": 0.12556517124176025, "2204": 0.05046287178993225, "2308": 0.5990082025527954, "2313": 0.4873090982437134, "... | 20491205 | The prison population is increasing and the health problems of prisoners are considerable. Prison is designed with punishment, correction and rehabilitation to the community in mind and these goals may conflict with the aims of health care. A literature review showed that the main issues in prison health care are menta... | Prison health care: a review of the literature. |
{"1048": 0.06612417846918106, "2001": 0.46055975556373596, "2003": 0.043007105588912964, "2029": 0.25845035910606384, "2034": 0.3262358605861664, "2038": 0.1905880719423294, "2042": 0.40546512603759766, "2043": 0.609149694442749, "2086": 0.08064348995685577, "2095": 0.5278670787811279, "2106": 0.520350456237793, "2109"... | 20492020 | Since the discovery of long-term potentiation (LTP) in 1973, thousands of papers have been published on this intriguing phenomenon, which provides a compelling cellular model for learning and memory. Although LTP has suffered considerable growing pains over the years, LTP has finally come of age. Here the rich history ... | A Brief History of Long-Term Potentiation |
{"1011": 0.19782574474811554, "1020": 0.997294545173645, "1040": 0.14602625370025635, "1043": 0.2493593990802765, "2002": 0.755608320236206, "2011": 0.12814582884311676, "2029": 0.1485546976327896, "2050": 0.822151780128479, "2084": 0.034552380442619324, "2179": 0.043007105588912964, "2243": 0.0009760859538801014, "231... | 20501163 | In patients with cancer, the wasting syndrome, cachexia, is associated with caloric deficiency. Here, we describe tumor-induced alterations of the host metabolic response to caloric deficiency that cause intratumoral immune suppression. In pre-cachectic mice with transplanted colorectal cancer or autochthonous pancreat... | Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity |
{"1011": 0.2501201331615448, "1998": 0.04953393340110779, "2003": 0.045809537172317505, "2024": 0.26820653676986694, "2029": 0.1485546976327896, "2078": 0.08692999184131622, "2079": 0.13755162060260773, "2092": 0.2247048318386078, "2110": 0.11517547070980072, "2128": 0.14602625370025635, "2152": 0.083342544734478, "216... | 20524091 | Self-renewal and differentiation of stem cells are tightly regulated processes subject to intrinsic and extrinsic signals. Molecular chaperones and co-chaperones, especially heat shock proteins (Hsp), are ubiquitous molecules involved in the modulation of protein conformational and complexation states. The function of ... | Chaperoning stem cells: a role for heat shock proteins in the modulation of stem cell self-renewal and differentiation? |
{"1014": 0.2990913391113281, "1018": 0.15943801403045654, "1019": 0.18004031479358673, "1020": 0.21372433006763458, "1999": 0.2317005842924118, "2020": 0.029824240133166313, "2026": 0.684319257736206, "2028": 0.12728634476661682, "2033": 0.151916041970253, "2043": 0.0752234235405922, "2048": 0.15526613593101501, "2051"... | 20526907 | OBJECTIVE To quantify the effects of quantity and frequency of alcohol consumption on risk of acute myocardial infarction and coronary death. DESIGN Case-control study. SETTING Lower Hunter region of New South Wales, Australia, 1983-94. SUBJECTS Men and women aged 35-69 years. MAIN OUTCOME MEASURE Acute myocardial infa... | How much alcohol and how often? Population based case-control study of alcohol consumption and risk of a major coronary event. |
{"1005": 0.012615402229130268, "1044": 0.7610978484153748, "2002": 0.11517547070980072, "2011": 0.07793712615966797, "2013": 0.43623676896095276, "2029": 0.23247487843036652, "2043": 0.47827014327049255, "2051": 0.23710809648036957, "2076": 0.5427330136299133, "2080": 0.037378571927547455, "2081": 0.036437395960092545,... | 20532591 | White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure. During cold-induced 'browning' of subcutaneous fat, most 'bei... | Tracking adipogenesis during white adipose tissue development, expansion and regeneration |
{"1051": 0.1602703034877777, "1052": 0.06612417846918106, "1999": 0.37907835841178894, "2005": 0.10203468054533005, "2007": 0.14095009863376617, "2011": 0.10379679501056671, "2029": 0.11256109178066254, "2044": 0.791648268699646, "2064": 0.0174254160374403, "2076": 0.1734936386346817, "2077": 0.3560888469219208, "2078"... | 20544428 | Recent studies have highlighted the involvement of the peripheral immune system in delayed cellular degeneration after stroke. In the permanent middle cerebral artery occlusion (MCAO) model of stroke, the spleen decreases in size. This reduction occurs through the release of splenic immune cells. Systemic treatment wit... | Blockade of adrenoreceptors inhibits the splenic response to stroke. |
{"1014": 0.3963087201118469, "1016": 0.6639154553413391, "1020": 0.07884006202220917, "1052": 0.7220231294631958, "1081": 0.7210738658905029, "1999": 0.3560888469219208, "2005": 0.3588210940361023, "2007": 0.05417001247406006, "2029": 0.09495500475168228, "2044": 0.5232481360435486, "2048": 0.15023678541183472, "2050":... | 20554003 | Anti-inflammatory therapy decreases infarct size and enhances stroke recovery. Thiazolidinedione peroxisome proliferator-activated receptor (PPAR)gamma agonists have potent anti-inflammatory and insulin-sensitizing anti-diabetic actions. Thirty stroke patients with type 2 diabetes admitted for acute inpatient stroke re... | Effects of Thiazolidinediones on Stroke Recovery: A Case-Matched Controlled Study |
{"1011": 0.009718249551951885, "1015": 0.3027053773403168, "1044": 0.6833335757255554, "1047": 0.10467668622732162, "2007": 0.06246116757392883, "2008": 0.13755162060260773, "2011": 0.4450363218784332, "2015": 0.4734157919883728, "2029": 0.25239890813827515, "2066": 0.23402166366577148, "2076": 0.13243216276168823, "20... | 20568364 | While significant progress has been made in understanding the induction of tumor vasculature by secreted angiogenic factors, little is known regarding contact-dependent signals that promote tumor angiogenesis. Here, we report that the Notch ligand Jagged1 induced by growth factors via mitogen-activating protein kinase ... | Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. |
{"1011": 0.13414156436920166, "1017": 0.18492233753204346, "1018": 0.2247048318386078, "1019": 0.3416208028793335, "1041": 1.0312920808792114, "1048": 0.17431432008743286, "1052": 0.6000806093215942, "1055": 0.016465263441205025, "1997": 0.02887592278420925, "2008": 0.026025565341114998, "2011": 0.29981520771980286, "2... | 20585600 | To explore the structural basis of alternative splicing, we have analyzed the splicing of pre-mRNAs containing an optional exon, E4, from the preprotachykinin gene. This gene encodes substance P and related tachykinin peptides by alternative splicing of a common pre-mRNA. We have shown that alternative splicing of prep... | A Sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5' splice site in preprotachykinin pre-mRNA. |
{"1019": 0.30989447236061096, "1041": 0.13414156436920166, "1996": 0.10026945173740387, "1997": 0.14518201351165771, "1999": 0.04860413447022438, "2004": 0.04674193635582924, "2005": 0.026976587250828743, "2007": 0.03360854089260101, "2011": 0.2247048318386078, "2029": 0.21214580535888672, "2044": 0.18004031479358673, ... | 20602517 | The endogenous circadian rhythm of melatonin, driven by the suprachiasmatic nucleus, exhibits a close association with the endogenous circadian component of the sleep propensity rhythm and the endogenous circadian component of the variation in electroencephalogram (EEG) oscillations such as sleep spindles and slow wave... | Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. |
{"1003": 0.06795065850019455, "1019": 0.029824240133166313, "1041": 0.5718178153038025, "1053": 1.1935672760009766, "1061": 0.15442965924739838, "1997": 0.5174443125724792, "2001": 0.0606246218085289, "2004": 0.13925230503082275, "2012": 0.13071982562541962, "2015": 0.2247048318386078, "2020": 0.006812678650021553, "20... | 20606520 | OBJECTIVES To assess mortality, quality of life (QOL), and quality-adjusted life-years (QALYs) for critically ill elderly patients. DESIGN Cross-sectional survey. SETTING A ten-bed medical-surgical intensive care unit (ICU) in a tertiary care university hospital. PATIENTS The study group included 882 elderly patients (... | Long-term survival, quality of life, and quality-adjusted life-years among critically ill elderly patients. |
{"1048": 0.30486753582954407, "1050": 0.026025565341114998, "1999": 0.018384648486971855, "2000": 0.06246116757392883, "2003": 0.006812678650021553, "2005": 0.043007105588912964, "2013": 0.5438674688339233, "2015": 0.2026219218969345, "2071": 0.3012613356113434, "2079": 0.0797421783208847, "2083": 0.7665573358535767, "... | 20608982 | PURPOSE OF REVIEW As the migration of neutrophils from blood to inflamed tissues is an essential component of innate immunity and a key contributing factor to the pathogenesis of inflammatory disorders, this aspect of leukocyte biology continues to be a highly dynamic field of research. This review summarizes recent fi... | Recent developments and complexities in neutrophil transmigration. |
{"1023": 0.2918238639831543, "1997": 0.021256839856505394, "2001": 0.2089812457561493, "2002": 0.23556606471538544, "2010": 0.7592713832855225, "2012": 0.10555581003427505, "2020": 0.14349138736724854, "2042": 0.09406650811433792, "2043": 0.37102460861206055, "2084": 0.09672962874174118, "2086": 0.34370049834251404, "2... | 20610390 | OBJECTIVES To investigate incidence, mortality and case survival trends for cancer of unknown primary site (CUP) and consider clinical implications. METHOD South Australian Cancer Registry data were used to calculate age-standardised incidence and mortality rates from 1977 to 2004. Disease-specific survivals, socio-dem... | Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: implications for research and clinical care. |
{"1009": 0.8772575259208679, "1011": 0.11430477350950241, "1018": 0.33115679025650024, "1038": 0.06429435312747955, "1039": 0.07431721687316895, "1041": 0.022212404757738113, "1048": 0.46486347913742065, "1056": 0.9131608605384827, "1998": 0.05694137513637543, "2005": 0.1930064558982849, "2007": 0.5267143249511719, "20... | 20610557 | In recent years, the immune-potentiating effects of some widely used chemotherapeutic agents have been increasingly appreciated. This provides a rationale for combining conventional chemotherapy with immunotherapy strategies to achieve durable therapeutic benefits. Previous studies have implicated the immunomodulatory ... | Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells. |
{"1014": 0.2089812457561493, "1041": 0.5209306478500366, "1048": 0.15442965924739838, "2005": 0.1994270235300064, "2007": 0.20818853378295898, "2038": 0.004870930220931768, "2044": 0.16442140936851501, "2063": 0.20818853378295898, "2064": 0.083342544734478, "2079": 0.05694137513637543, "2084": 0.3485364317893982, "2090... | 20611846 | BACKGROUND Although inhaled corticosteroids have an established role in the treatment of asthma, studies have tended to concentrate on non-smokers and little is known about the possible effect of cigarette smoking on the efficacy of treatment with inhaled steroids in asthma. A study was undertaken to investigate the ef... | Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. |
{"1047": 0.8957691192626953, "1997": 0.058784693479537964, "2000": 0.23787821829319, "2005": 0.19381128251552582, "2008": 0.07068414986133575, "2011": 0.28450319170951843, "2015": 0.35745587944984436, "2029": 0.04767346754670143, "2037": 0.2034190446138382, "2047": 0.27044451236724854, "2048": 0.23402166366577148, "206... | 20620012 | Through phosphorylation, protein kinases can alter the activity, localization, protein association, and stability of their targets. Despite the importance to our understanding of all aspects of cell biology, progress toward identifying bona fide substrates of specific protein kinases has been slow. Traditionally used t... | Hitting the target: emerging technologies in the search for kinase substrates. |
{"1044": 0.7473171949386597, "1052": 0.18329764902591705, "1060": 0.7500885725021362, "2002": 0.4349733293056488, "2003": 0.2026219218969345, "2004": 0.007782140281051397, "2005": 0.10731173306703568, "2010": 1.3555532693862915, "2011": 0.3027053773403168, "2024": 0.13157635927200317, "2029": 0.053244512528181076, "203... | 20630805 | Histone posttranslational modifications are key components of diverse processes that modulate chromatin structure. These marks function as signals during various chromatin-based events, and act as platforms for recruitment, assembly or retention of chromatin-associated factors. The best-known function of histone phosph... | Histone phosphorylation: a chromatin modification involved in diverse nuclear events. |
{"1008": 0.026976587250828743, "1014": 0.15860503911972046, "1020": 0.043007105588912964, "1045": 0.21530038118362427, "2001": 0.007782140281051397, "2005": 0.05694137513637543, "2012": 0.11256109178066254, "2044": 0.1221139207482338, "2053": 0.09584271162748337, "2063": 0.11430477350950241, "2077": 0.0770333781838417,... | 20645335 | OBJECTIVE To systematically review and integrate data on the neurodevelopmental outcome of children after administration of a single course of antenatal corticosteroids for threatened preterm labor. DATA SOURCES MEDLINE, Scopus, CENTRAL, and www.clinicaltrials.gov (inception to August 2014) using combinations of the te... | Neurodevelopmental Outcome After a Single Course of Antenatal Steroids in Children Born Preterm: A Systematic Review and Meta-analysis. |
{"1003": 0.04113444685935974, "1017": 0.0317181795835495, "1019": 0.0913962796330452, "1023": 0.175953671336174, "1026": 0.083342544734478, "1041": 0.4151833653450012, "1052": 0.4248080551624298, "1609": 0.026025565341114998, "2001": 0.07884006202220917, "2007": 0.14518201351165771, "2044": 0.0752234235405922, "2051": ... | 20645538 | PURPOSE Minimal (< 10 mm thick) pleural effusion (PE) may represent an early phase of malignant PE, but its clinical relevance has rarely been studied. Therefore, we examined the proportion of minimal PE in patients with non-small-cell lung cancer (NSCLC) and its impact on survival. We also considered possible accumula... | Prognostic impact of minimal pleural effusion in non-small-cell lung cancer. |
{"1009": 0.8550800085067749, "1011": 0.18816383183002472, "1018": 0.1710275560617447, "1022": 0.4950772523880005, "1038": 0.7482418417930603, "1039": 0.28450319170951843, "1045": 0.2089812457561493, "1048": 0.19381128251552582, "1049": 0.6363908052444458, "1051": 0.06795065850019455, "1055": 0.27342069149017334, "1056"... | 20646904 | Targeting of proteins to APCs is an attractive strategy for eliciting adaptive immune responses. However, the relationship between the choice of the targeted receptor and the quality and quantity of responses remains poorly understood. We describe a strategy for expression of Ags including hydrophobic proteins as solub... | Fusion proteins for versatile antigen targeting to cell surface receptors reveal differential capacity to prime immune responses. |
{"1011": 0.2786078155040741, "1043": 0.2516399025917053, "1996": 0.30989447236061096, "1997": 0.013579257763922215, "1998": 0.19381128251552582, "1999": 0.31204116344451904, "2007": 0.09938567131757736, "2008": 0.025073638185858727, "2011": 0.5220900774002075, "2015": 0.24018502235412598, "2029": 0.2089812457561493, "2... | 20649327 | The TAP proteins translocate antigenic peptides into the endoplasmic reticulum. Investigation of the specificity of this process has been complicated by TAP-independent factors that influence the amount of peptide that accumulates in the ER in transport assays. We have developed an overexpression system in which bindin... | A sequential model for peptide binding and transport by the transporters associated with antigen processing. |
{"1016": 0.12470348179340363, "1043": 1.1738357543945312, "1053": 0.029824240133166313, "1054": 0.48430517315864563, "1157": 0.5244048833847046, "2007": 0.06337817758321762, "2012": 0.040196798741817474, "2034": 0.3750596046447754, "2043": 0.006812678650021553, "2044": 0.890972912311554, "2047": 0.052318159490823746, "... | 20649735 | OBJECTIVE We investigated the outcome of repeated gamma knife radiosurgery (GKS) for local or remote recurrence after initial radiosurgery. MATERIAL AND METHODS We retrospectively reviewed 204 patients who were treated with GKS. Among them 43 patients (21%) underwent GKS more than once. The second GKS was given for rec... | Outcome of repeated radiosurgery for recurrent metastatic brain tumors. |
{"1011": 0.016465263441205025, "1041": 0.41065993905067444, "1052": 1.0087559223175049, "1054": 0.03831886500120163, "1060": 1.2065086364746094, "1999": 0.016465263441205025, "2002": 0.4855078160762787, "2003": 0.23633737862110138, "2011": 0.48670899868011475, "2029": 0.2539152204990387, "2062": 0.18329764902591705, "2... | 20659283 | Pregnane X receptor (PXR) is an important component of the body's adaptive defense system responsible for the elimination of various toxic xenobiotics. PXR activation by endogenous and exogenous chemicals, including steroids, antibiotics, bile acids, and herbal compounds, results in induction of drug metabolism. We inv... | Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. |
{"1011": 0.08064348995685577, "1014": 0.0913962796330452, "1017": 0.129004567861557, "1020": 0.684319257736206, "1043": 0.6619023680686951, "1044": 0.3084607720375061, "1048": 0.6207655072212219, "1997": 0.32199856638908386, "1999": 0.3877306580543518, "2002": 0.8813109993934631, "2004": 0.24631060659885406, "2011": 0.... | 20672596 | Maximum activities of some key enzymes of metabolism were studied in elicited (inflammatory) macrophages of the mouse and lymph-node lymphocytes of the rat. The activity of hexokinase in the macrophage is very high, as high as that in any other major tissue of the body, and higher than that of phosphorylase or 6-phosph... | Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. |
{"1011": 0.41840189695358276, "1039": 0.3353555500507355, "1041": 0.9170717000961304, "1042": 0.5461324453353882, "1043": 0.30486753582954407, "1056": 1.117316484451294, "1156": 0.29400965571403503, "2003": 0.16110190749168396, "2008": 0.02792670577764511, "2011": 0.3269403576850891, "2026": 0.3750596046447754, "2029":... | 20675284 | Transforming growth factor-beta (TGF-beta) inhibits the growth of endothelial cells derived from various sources, including human umbilical vein, bovine aorta, and rat heart. Long-term exposure of rat heart endothelial cells to TGF-beta also induces dramatic changes in morphology that are characteristic of senescent ce... | TGF-beta inhibition of endothelial cell proliferation: alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression. |
{"1011": 0.07250232994556427, "1015": 0.27044451236724854, "1018": 0.08961215615272522, "1038": 0.20501139760017395, "1047": 0.18978065252304077, "1048": 0.029824240133166313, "2005": 0.2493593990802765, "2006": 0.2763880789279938, "2007": 0.32553088665008545, "2011": 0.5444341897964478, "2029": 0.1710275560617447, "20... | 20690388 | Natural killer (NK) cell activation is strictly regulated to ensure that healthy cells are preserved, but tumour-transformed or virus-infected cells are recognized and eliminated. To carry out this selective killing, NK cells have an ample repertoire of receptors on their surface. Signalling by inhibitory and activatin... | Human NK cells in acute myeloid leukaemia patients: analysis of NK cell-activating receptors and their ligands |
{"1011": 0.26296505331993103, "1017": 0.04674193635582924, "1019": 0.03831886500120163, "1020": 0.981317400932312, "1042": 0.678390383720398, "1044": 0.16690383851528168, "1045": 0.016465263441205025, "1048": 0.021256839856505394, "1059": 0.5336109399795532, "1999": 0.12556517124176025, "2011": 0.3127557039260864, "201... | 20696397 | 1. Plasma interleukin (IL)-6 concentration is increased with exercise and it has been demonstrated that contracting muscles can produce IL-The question addressed in the present study was whether the IL-6 production by contracting skeletal muscle is of such a magnitude that it can account for the IL-6 accumulating in th... | Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. |
{"1043": 0.020300358533859253, "1044": 0.7333439588546753, "1998": 0.02792670577764511, "2007": 0.45251765847206116, "2037": 0.1718502640724182, "2050": 0.8450632095336914, "2109": 0.004870930220931768, "2116": 0.05786345899105072, "2135": 0.6734226942062378, "2155": 0.2719337046146393, "2168": 0.07341018319129944, "21... | 20697217 | OBJECTIVE To examine the symptoms of hypoglycemia in children with insulin-dependent diabetes, from the perspective both of the child and of the child's parents, and to compare the symptom reporting of the diabetic children with that of adult diabetic patients. RESEARCH DESIGN AND METHODS Interviews were conducted with... | Symptoms of hypoglycemia in children with IDDM. |
{"1011": 0.10467668622732162, "1017": 0.2231435477733612, "2003": 0.27786844968795776, "2062": 0.24171993136405945, "2093": 0.3622259199619293, "2099": 0.09406650811433792, "2109": 0.15359249711036682, "2121": 0.28670501708984375, "2124": 0.08603433519601822, "2129": 0.34715715050697327, "2139": 0.4267219603061676, "21... | 20707861 | Comparative protein structure modeling predicts the three-dimensional structure of a given protein sequence (target) based primarily on its alignment to one or more proteins of known structure (templates). The prediction process consists of fold assignment, target-template alignment, model building, and model evaluatio... | Comparative Protein Structure Modeling Using MODELLER. |
{"1011": 0.4770587682723999, "1020": 1.0668635368347168, "1045": 0.25088030099868774, "2005": 0.14939609169960022, "2029": 0.2830325961112976, "2038": 0.07159364968538284, "2064": 0.10906458646059036, "2066": 0.34370049834251404, "2078": 0.43623676896095276, "2079": 0.08064348995685577, "2085": 0.045809537172317505, "2... | 20722510 | Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not of the immune system and often displays hormone-like characteristics that affect homeostatic processes. IL-6 has context-dependent pro- and anti-inflammatory properties and is now regarded as a prominent target for clinical intervention... | IL-6 as a keystone cytokine in health and disease |
{"1011": 0.3381449282169342, "1015": 0.04860413447022438, "1017": 0.18167030811309814, "1018": 0.38174858689308167, "1019": 0.6941232681274414, "1022": 0.4481603503227234, "1041": 0.48068851232528687, "1052": 0.10291612148284912, "1054": 0.8829278349876404, "1996": 0.40611594915390015, "1997": 0.24554696679115295, "199... | 20725212 | In eukaryotes, three of the four ribosomal RNAs (rRNAs)—the 5.8S, 18S, and 25S/28S rRNAs—are processed from a single pre-rRNA transcript and assembled into ribosomes. The fourth rRNA, the 5S rRNA, is transcribed by RNA polymerase III and is assembled into the 5S ribonucleoprotein particle (RNP), containing ribosomal pr... | Chaperoning 5S RNA assembly. |
{"1006": 0.12814582884311676, "1011": 0.24018502235412598, "1016": 0.495672345161438, "1041": 0.052318159490823746, "1052": 0.47463157773017883, "1999": 0.2026219218969345, "2011": 0.0797421783208847, "2029": 0.21530038118362427, "2048": 0.2918238639831543, "2063": 1.1592369079589844, "2064": 0.13925230503082275, "2094... | 20732789 | Cigarette smoke is the main cause of chronic obstructive pulmonary disease (COPD), where it can contribute to the observed airway inflammation. PGE(2) is produced within human airways, and both pro- and anti-inflammatory activities have been reported. We quantitated PGE(2) concentrations in induced sputum supernatants ... | Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products. |
{"1011": 0.12814582884311676, "1038": 0.890972912311554, "1041": 0.567951500415802, "1044": 0.34922540187835693, "1047": 0.20102575421333313, "1048": 0.19782574474811554, "1052": 0.4980490207672119, "1060": 0.9115922451019287, "1999": 0.04674193635582924, "2007": 0.1677299439907074, "2008": 0.08782484382390976, "2011":... | 20738970 | Epithelial and endothelial tyrosine kinase (Etk), also known as Bmx (bone marrow X kinase) plays an important role in apoptosis of epithelial cells. The goal of this study was to investigate whether Etk is involved in apoptosis of small cell lung cancer (SCLC) cells and correlated with the expression levels of apoptosi... | Non-receptor tyrosine kinase Etk is involved in the apoptosis of small cell lung cancer cells. |
{"1055": 0.22001366317272186, "1996": 0.5979346632957458, "1998": 0.004870930220931768, "2004": 0.2089812457561493, "2015": 1.1822543144226074, "2029": 0.15777134895324707, "2034": 0.1384023278951645, "2048": 0.15526613593101501, "2049": 0.015504186972975731, "2061": 0.6405166387557983, "2079": 0.2026219218969345, "209... | 20743803 | The transmission of information in the brain depends on the highly polarized architecture of neurons. A number of cellular transport processes support this organization, including active targeting of proteins and passive corralling between compartments. The axon initial segment (AIS), which separates the somatodendriti... | No Pasaran! Role of the axon initial segment in the regulation of protein transport and the maintenance of axonal identity. |
{"1011": 0.04113444685935974, "1014": 0.18978065252304077, "1019": 0.011650617234408855, "1020": 0.3870677351951599, "1054": 1.1506214141845703, "1997": 0.6260011196136475, "2001": 0.09761575609445572, "2022": 0.11081436276435852, "2034": 0.16110190749168396, "2043": 0.0752234235405922, "2044": 0.5478278398513794, "205... | 20746604 | OBJECTIVE To examine the association between the use of right heart catheterization (RHC) during the first 24 hours of care in the intensive care unit (ICU) and subsequent survival, length of stay, intensity of care, and cost of care. DESIGN Prospective cohort study. SETTING Five US teaching hospitals between 1989 and ... | The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators. |
{"1011": 0.32270604372024536, "1015": 0.2034190446138382, "1039": 0.020300358533859253, "1043": 0.5472630262374878, "1044": 0.6118015646934509, "1045": 0.5387523174285889, "1048": 0.5104349255561829, "1062": 0.5925496220588684, "1155": 0.2881702482700348, "1998": 0.09761575609445572, "2000": 0.25995752215385437, "2002"... | 20754359 | After cell-to-cell transmission, HTLV-I increases its viral genome by de novo infection and proliferation of infected cells. Proliferation of infected cells is clonal and persistent in vivo. During the carrier state, infected cells are selected in vivo by the host's immune system, the genetic and epigenetic environment... | Natural history of adult T-cell leukemia/lymphoma and approaches to therapy |
{"1037": 0.12384103983640671, "1042": 0.19381128251552582, "1996": 0.42353010177612305, "1997": 0.3070250153541565, "1999": 0.2018241584300995, "2015": 0.9379299283027649, "2028": 0.0770333781838417, "2029": 0.07159364968538284, "2033": 0.4752389192581177, "2048": 0.20501139760017395, "2051": 0.4462870955467224, "2073"... | 20758340 | Single-molecule tracking and fluorescence correlation spectroscopy (FCS) applied to the plasma membrane in living cells have allowed a number of unprecedented observations, thus fostering a new basic understanding of molecular diffusion, interaction, and signal transduction in the plasma membrane. It is becoming clear ... | Hierarchical organization of the plasma membrane: investigations by single-molecule tracking vs. fluorescence correlation spectroscopy. |
{"1011": 0.05139094591140747, "1021": 0.13157635927200317, "1040": 0.08244366943836212, "1048": 0.16607704758644104, "1999": 0.23479416966438293, "2003": 0.46486347913742065, "2004": 0.0842406153678894, "2012": 0.1384023278951645, "2020": 0.11951763927936554, "2024": 0.6064908504486084, "2050": 1.049919843673706, "2060... | 20761364 | Artemisinins are peroxidic antimalarial drugs known to be very potent but highly chemically unstable; they degrade in the presence of ferrous iron, Fe(II)-heme, or biological reductants. Less documented is how this translates into chemical stability and antimalarial activity across a range of conditions applying to in ... | Stability of the antimalarial drug dihydroartemisinin under physiologically relevant conditions: implications for clinical treatment and pharmacokinetic and in vitro assays. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.