spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1011": 0.2983669638633728, "1014": 0.034552380442619324, "1015": 0.17431432008743286, "1023": 0.37907835841178894, "1040": 0.16110190749168396, "1041": 0.1229778528213501, "1056": 0.0354953333735466, "1158": 0.7809720039367676, "1997": 0.05970508232712746, "1999": 0.12814582884311676, "2003": 0.09850110858678818, "20... | 20764484 | The psychoactive constituent of cannabis, Δ9-tetrahydrocannabinol, produces in humans subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous cannabinoids may contribute to the control of emotion. But the variable effects of Δ9-tetrahydrocannabinol obscure the interpretation of these resu... | Modulation of anxiety through blockade of anandamide hydrolysis |
{"1003": 0.04953393340110779, "1014": 0.3012613356113434, "1020": 0.1401015669107437, "1042": 0.13157635927200317, "1043": 0.03266380727291107, "1044": 0.7201237678527832, "1052": 0.32553088665008545, "1055": 0.34023189544677734, "1998": 0.05970508232712746, "1999": 0.20022670924663544, "2002": 0.053244512528181076, "2... | 20767776 | Objective:A number of case reports describe multiple family members with gastroesophageal reflux disease and Barrett's esophagus. The wider importance of familial factors in gastroesophageal reflux disease has not been established. Therefore, we have studied the prevalence of reflux symptoms and medication use among re... | Familial clustering of reflux symptoms |
{"1011": 0.33605360984802246, "1044": 0.5033760666847229, "1996": 0.10906458646059036, "1997": 0.18248429894447327, "2001": 0.3824150264263153, "2002": 0.23787821829319, "2004": 0.6989894509315491, "2010": 1.1738357543945312, "2029": 0.15275461971759796, "2031": 0.018384648486971855, "2034": 0.5646255612373352, "2037":... | 20781656 | Some three decades have passed since the discovery of nucleosomes in 1974 and the first isolation of a histone chaperone in 1978. While various types of histone chaperones have been isolated and functionally analyzed, the elementary processes of nucleosome assembly and disassembly have been less well characterized. Rec... | Histone chaperones: 30 years from isolation to elucidation of the mechanisms of nucleosome assembly and disassembly |
{"1005": 0.15943801403045654, "1011": 0.28670501708984375, "1017": 0.0354953333735466, "1019": 0.6563454270362854, "1047": 0.36697331070899963, "1048": 0.5855054259300232, "1155": 0.24631060659885406, "1156": 0.33953672647476196, "1997": 0.06703783571720123, "1999": 0.02887592278420925, "2003": 0.03831886500120163, "20... | 20821402 | Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-associated nucleotide damage, including base loss (abasic site or 5'-dRP/AP sites). Ku, a 5'-dRP/AP lyase, can excise such damage at ends in preparation for the ligation ... | Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends. |
{"1011": 0.40351006388664246, "1015": 0.7276995778083801, "1043": 1.04512357711792, "1048": 0.7881022095680237, "1996": 0.09761575609445572, "1999": 0.11343330889940262, "2005": 0.16110190749168396, "2008": 0.029824240133166313, "2011": 0.45623743534088135, "2013": 0.37371641397476196, "2028": 0.2837681770324707, "2029... | 20829129 | Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors, the taste G protein... | Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. |
{"1011": 0.08692999184131622, "1020": 0.10555581003427505, "1044": 0.10818854719400406, "1048": 0.42990362644195557, "1052": 0.6476961374282837, "1055": 0.5404602885246277, "1853": 0.32905077934265137, "1999": 0.03925827145576477, "2002": 0.16359257698059082, "2003": 0.20102575421333313, "2004": 0.004870930220931768, "... | 20839751 | Apoptosis is a frequent phenomenon in breast cancer and it can be detected by light microscopy in conventional histopathological sections or by special staining techniques. The number of apoptotic cells as a percentage of cells present, or the number of apoptotic cells per square millimetre of neoplastic tissue, is usu... | Apoptosis in breast cancer: relationship with other pathological parameters. |
{"1020": 0.2659635543823242, "1042": 0.12642613053321838, "1043": 0.3615458607673645, "1997": 0.1602703034877777, "1999": 0.32764431834220886, "2002": 0.3723714053630829, "2003": 0.09938567131757736, "2004": 0.10379679501056671, "2005": 0.1477125883102417, "2015": 0.007782140281051397, "2024": 0.31845372915267944, "202... | 20851402 | Flavonoids comprise the most common group of plant polyphenols and provide much of the flavor and color to fruits and vegetables. More than 5000 different flavonoids have been described. The six major subclasses of flavonoids include the flavones (e.g., apigenin, luteolin), flavonols (e.g., quercetin, myricetin), flava... | Dietary flavonoids: bioavailability, metabolic effects, and safety. |
{"1011": 0.4770587682723999, "1039": 0.3283478021621704, "1045": 0.18248429894447327, "1048": 0.5104349255561829, "1056": 0.9131608605384827, "1999": 0.2231435477733612, "2007": 0.10555581003427505, "2010": 0.6639154553413391, "2011": 0.20501139760017395, "2029": 0.2516399025917053, "2043": 0.02792670577764511, "2044":... | 20864487 | Cytotoxic T-lymphocyte (CTL) responses to human immunodeficiency virus arise early after infection, but ultimately fail to prevent progression to AIDS. Human immunodeficiency virus may evade the CTL response by accumulating amino-acid replacements within CTL epitopes. We studied 10 CTL epitopes during the course of sim... | Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef |
{"1017": 0.043007105588912964, "1043": 0.3757305145263672, "1044": 0.15023678541183472, "1056": 0.02792670577764511, "2011": 0.16442140936851501, "2029": 0.26296505331993103, "2031": 0.13499516248703003, "2038": 0.25694093108177185, "2048": 0.11256109178066254, "2050": 0.016465263441205025, "2057": 0.012615402229130268... | 20868160 | The Arabidopsis (Arabidopsis thaliana) trichome birefringence (tbr) mutant has severely reduced crystalline cellulose in trichomes, but the molecular nature of TBR was unknown. We determined TBR to belong to the plant-specific DUF231 domain gene family comprising 46 members of unknown function in Arabidopsis. The genes... | TRICHOME BIREFRINGENCE and its homolog AT5G01360 encode plant-specific DUF231 proteins required for cellulose biosynthesis in Arabidopsis. |
{"1009": 0.4151833653450012, "1013": 0.010684899985790253, "1014": 0.018384648486971855, "1017": 0.14349138736724854, "1018": 0.14686977863311768, "1022": 0.09938567131757736, "1042": 0.31560876965522766, "1050": 0.034552380442619324, "1052": 0.22937409579753876, "1055": 0.7258110046386719, "1056": 0.29036402702331543,... | 20886584 | Taxanes have resulted in improved survival for breast cancer patients, but often cause neurological toxicities. Identification of biomarkers related to toxicities could be important for dictating treatment regimen. We evaluated single nucleotide polymorphisms (SNPs) in the Fanconi Anemia (FA)/BRCA pathway in relation t... | Genetic predictors of taxane-induced neurotoxicity in a SWOG phase III intergroup adjuvant breast cancer treatment trial (S0221) |
{"1011": 0.32270604372024536, "1014": 0.03925827145576477, "1019": 0.08244366943836212, "1039": 0.9409833550453186, "1052": 0.3982778787612915, "2005": 0.02316705882549286, "2010": 0.7067264318466187, "2015": 0.007782140281051397, "2043": 0.02412080205976963, "2044": 0.6244332790374756, "2076": 0.24859806895256042, "20... | 20887554 | BACKGROUND C-reactive protein (CRP) is a known risk factor for cardiovascular events in the healthy population and in patients with coronary artery disease. High CRP levels before cardiac surgery are associated with worse short-term outcome, but its role after discharge home remains unknown. The study objective was to ... | Preoperative C-reactive protein predicts mid-term outcome after cardiac surgery. |
{"1011": 0.053244512528181076, "1040": 0.4337083101272583, "1052": 0.4311734735965729, "1999": 0.11604541540145874, "2003": 0.272677481174469, "2005": 0.14179791510105133, "2007": 0.0797421783208847, "2011": 0.06977381557226181, "2029": 0.12642613053321838, "2050": 1.187628984451294, "2071": 0.13925230503082275, "2072"... | 20888849 | Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, we found that the tumors in this model were poorly perfused and poorly vascularized, p... | Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. |
{"1011": 0.3127557039260864, "1013": 0.4158279001712799, "1015": 0.23402166366577148, "1048": 0.417115718126297, "1051": 0.22548456490039825, "1062": 1.0423725843429565, "1999": 0.11691460013389587, "2011": 0.37102460861206055, "2029": 0.2719337046146393, "2046": 0.23710809648036957, "2058": 0.33325836062431335, "2061"... | 20904154 | Cu/Zn-superoxide dismutase is misfolded in familial and sporadic amyotrophic lateral sclerosis, but it is not clear how this triggers endoplasmic reticulum (ER) stress or other pathogenic processes. Here, we demonstrate that mutant SOD1 (mSOD1) is predominantly found in the cytoplasm in neuronal cells. Furthermore, we ... | Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis. |
{"1014": 0.12384103983640671, "1041": 1.2273306846618652, "1999": 0.4425300657749176, "2001": 0.13925230503082275, "2015": 0.15275461971759796, "2019": 0.440646231174469, "2043": 0.21214580535888672, "2058": 0.22782009840011597, "2073": 0.5629584193229675, "2095": 0.26446542143821716, "2109": 0.15860503911972046, "2111... | 20931483 | Understanding local variability in malaria transmission risk is critically important when designing intervention or vaccine trials. Using a combination of field data, satellite image analysis, and GIS modeling, we developed a high-resolution map of malaria entomological inoculation rates (EIR) in The Gambia, West Afric... | High spatial resolution mapping of malaria transmission risk in the Gambia, west Africa, using LANDSAT TM satellite imagery. |
{"1011": 0.21922965347766876, "1016": 0.2501201331615448, "1020": 0.34922540187835693, "1021": 0.45499902963638306, "1044": 0.7248653769493103, "1045": 0.21922965347766876, "1047": 0.8289952278137207, "1057": 0.987156867980957, "1996": 0.037378571927547455, "2005": 0.022212404757738113, "2011": 0.25995752215385437, "20... | 20935673 | Spatial boundaries of homeotic gene expression are initiated and maintained by two sets of transcriptional repressors: the gap gene products and the Polycomb group proteins. Previously, the Hunchback (HB) protein has been implicated in setting the anterior expression limit of the UBX homeotic protein in parasegment 6. ... | Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene. |
{"1011": 0.24171993136405945, "1014": 0.4374985992908478, "1018": 0.4145384132862091, "1037": 0.7286425232887268, "1041": 1.2964379787445068, "1062": 0.1221139207482338, "1159": 0.2607102394104004, "1999": 0.11951763927936554, "2003": 0.07068414986133575, "2006": 0.10379679501056671, "2013": 0.0317181795835495, "2029":... | 20937018 | Apolipoprotein E is immunochemically localized to the senile plaques, vascular amyloid, and neurofibrillary tangles of Alzheimer disease. In vitro, apolipoprotein E in cerebrospinal fluid binds to synthetic beta A4 peptide (the primary constituent of the senile plaque) with high avidity. Amino acids 12-28 of the beta A... | Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. |
{"1011": 0.12814582884311676, "1041": 0.6578640341758728, "1042": 0.35334911942481995, "1043": 0.34715715050697327, "1052": 0.6764062643051147, "1055": 0.8509185314178467, "1156": 0.6461620330810547, "1158": 0.47584590315818787, "2000": 0.1602703034877777, "2001": 0.17922431230545044, "2003": 0.20818853378295898, "2004... | 20942644 | Sulfolobus islandicus is being used as a model for studying archaeal biology, geo-biology and evolution. However, no genetic system is available for this organism. To produce an S. islandicus mutant suitable for genetic analyses, we screened for colonies with a spontaneous pyrEF mutation. One mutant was obtained contai... | Unmarked gene deletion and host–vector system for the hyperthermophilic crenarchaeon Sulfolobus islandicus |
{"1011": 0.32129061222076416, "1041": 0.16276304423809052, "2002": 0.5618454217910767, "2003": 0.25995752215385437, "2005": 0.1064341589808464, "2006": 0.13670019805431366, "2007": 0.29328158497810364, "2008": 0.26296505331993103, "2011": 0.36426326632499695, "2029": 0.2763880789279938, "2063": 0.28450319170951843, "20... | 20943272 | ADAM13 is a member of the disintegrin and metalloprotease protein family that is expressed on cranial neural crest cells surface and is essential for their migration. ADAM13 is an active protease that can cleave fibronectin in vitro and remodel a fibronectin substrate in vivo. Using a recombinant secreted protein conta... | ADAM13 disintegrin and cysteine-rich domains bind to the second heparin-binding domain of fibronectin. |
{"1044": 0.48850810527801514, "2001": 0.3560888469219208, "2002": 0.09584271162748337, "2034": 0.09584271162748337, "2042": 0.1485546976327896, "2043": 0.5370414853096008, "2045": 0.09672962874174118, "2091": 0.06520967930555344, "2094": 0.129004567861557, "2095": 0.524982750415802, "2106": 0.25088030099868774, "2144":... | 20945963 | The aim of this paper is to review the clinical epidemiology of heart failure. The last paper comprehensively addressing the epidemiology of heart failure in Heart appeared in 2000. Despite an increase in manuscripts describing epidemiological aspects of heart failure since the 1990s, additional information is still ne... | Clinical epidemiology of heart failure. |
{"1011": 0.3870677351951599, "1020": 0.18492233753204346, "1021": 0.3923587501049042, "1038": 0.681853175163269, "1043": 0.5784112811088562, "1044": 0.5947071313858032, "1045": 0.29109421372413635, "1056": 0.669430673122406, "2002": 1.0137293338775635, "2005": 0.3784096837043762, "2007": 0.1905880719423294, "2010": 0.1... | 20960682 | BACKGROUND & AIMS GS-9620, an oral agonist of toll-like receptor 7 (TLR7), is in clinical development for the treatment of chronic hepatitis B (CHB). GS-9620 was previously shown to induce prolonged suppression of serum viral DNA and antigens in the woodchuck and chimpanzee models of CHB. Herein, we investigated the mo... | Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism. |
{"1011": 0.20102575421333313, "1018": 0.5033760666847229, "1042": 0.2822965085506439, "1043": 0.757441520690918, "1044": 0.5116065740585327, "1048": 0.46853771805763245, "1054": 0.4437839686870575, "1055": 0.2501201331615448, "2001": 0.0354953333735466, "2011": 0.11517547070980072, "2012": 0.12814582884311676, "2021": ... | 20977638 | Glutathione (GSH) homeostasis is important during organogenesis. To elucidate the impact of GSH depletion in organogenesis stage embryos on oxidative stress and drug teratogenicity, l-buthionine-S,R-sulfoximine (BSO) was given to timed pregnant CD-1 mice 4 h before exposure to a model teratogen, hydroxyurea (HU) [400 m... | Depletion of glutathione induces 4-hydroxynonenal protein adducts and hydroxyurea teratogenicity in the organogenesis stage mouse embryo. |
{"1011": 0.08692999184131622, "1015": 0.7038320899009705, "1043": 0.7258110046386719, "1045": 0.00875066313892603, "1048": 0.5284429788589478, "1053": 0.24401791393756866, "1056": 0.7086513638496399, "2000": 0.030771657824516296, "2005": 0.026025565341114998, "2011": 0.12642613053321838, "2028": 0.3170322775840759, "20... | 20996244 | Productive infection by human immunodeficiency virus type 1 (HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile, reverse transcripts. We have previously identified G1b as the cell cycle stage required for the optimal completion of the... | Nonproductive human immunodeficiency virus type 1 infection in nucleoside-treated G0 lymphocytes. |
{"1042": 0.30558720231056213, "1050": 0.052318159490823746, "1052": 0.1970241367816925, "2001": 0.05786345899105072, "2003": 0.09761575609445572, "2012": 0.11168810725212097, "2013": 0.5472630262374878, "2043": 0.22157983481884003, "2047": 0.1229778528213501, "2062": 0.24018502235412598, "2073": 0.4400174915790558, "20... | 20999249 | BACKGROUND Falciparum malaria or malaria tropica is one of the leading causes of childhood mortality worldwide. Malaria-related deaths occur mainly in sub-Saharan Africa, where an estimated 365 million clinical cases of Plasmodium falciparum malaria occur each year. In Europe, imported malaria cases occur due to return... | Imported malaria in children: a national surveillance in the Netherlands and a review of European studies. |
{"1014": 0.5903874635696411, "1018": 0.09584271162748337, "1019": 0.04674193635582924, "1026": 0.052318159490823746, "1044": 0.23864774405956268, "1052": 0.42161011695861816, "1999": 0.04953393340110779, "2003": 0.1229778528213501, "2007": 0.08871890604496002, "2012": 0.3353555500507355, "2020": 0.09938567131757736, "2... | 21003930 | BACKGROUND Long-term exposure to pollution can lead to an increase in the rate of decline of lung function, especially in older individuals and in those with chronic obstructive pulmonary disease (COPD), whereas shorter-term exposure at higher pollution levels has been implicated in causing excess deaths from ischaemic... | Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study |
{"1014": 0.055094651877880096, "1023": 0.04394211992621422, "1051": 0.6254787445068359, "1056": 0.469759464263916, "2007": 0.040196798741817474, "2020": 0.011650617234408855, "2025": 0.05970508232712746, "2026": 0.40806588530540466, "2044": 0.347847044467926, "2076": 0.36697331070899963, "2079": 0.09761575609445572, "2... | 21009874 | CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort study evaluating overall and cancer mortality in relation to immunosuppressive drug exposure among patients with ocular inflammatory dise... | Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study. |
{"1011": 0.1734936386346817, "1038": 0.7737906575202942, "1041": 0.6813592314720154, "1042": 0.8074519634246826, "1043": 0.9394577741622925, "1056": 0.8933739066123962, "2008": 0.13755162060260773, "2011": 0.2637155055999756, "2029": 0.304147332906723, "2062": 0.23787821829319, "2076": 0.04394211992621422, "2078": 0.47... | 21012916 | Follicular T helper (TFH) cells orchestrate the germinal center (GC) reaction locally. Local mechanisms regulating their dynamics and helper functions are not well defined. Here we found that GC-expressed ephrin B1 (EFNB1) repulsively inhibited T cell to B cell adhesion and GC TFH retention by signaling through TFH-exp... | Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function |
{"1011": 0.31560876965522766, "1014": 0.04860413447022438, "1039": 0.15777134895324707, "1052": 0.009718249551951885, "2007": 0.04860413447022438, "2013": 0.13414156436920166, "2014": 1.0795515775680542, "2029": 0.10203468054533005, "2076": 0.38905516266822815, "2077": 0.5483922958374023, "2099": 0.42096930742263794, "... | 21033230 | Purpose We analyzed circulating tumor cells (CTC) in blood of metastatic breast cancer patients (n = 42) and determined the ability of this method to predict therapy response. Methods CTC from blood were analyzed before and during therapy for EpCAM, MUC1 and HER2 transcripts with the AdnaTest BreastCancer. The estrogen... | Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: an option for monitoring response to breast cancer related therapies |
{"1041": 0.30917787551879883, "1056": 0.3318578004837036, "1998": 0.3163207769393921, "2006": 0.21687394380569458, "2011": 0.007782140281051397, "2020": 0.08603433519601822, "2025": 0.22782009840011597, "2037": 0.1913948506116867, "2043": 0.015504186972975731, "2044": 0.029824240133166313, "2049": 0.21372433006763458, ... | 21046889 | For rats access to a running wheel results in a pronounced but temporary suppression of feeding. The reasons for the feeding suppression and its temporary nature are unclear. The effects of alternate-day wheel access were explored by comparing feeding and running in 25 male Sprague-Dawley rats given either no wheel acc... | Alternate-day wheel access: effects on feeding, body weight, and running. |
{"1014": 0.13071982562541962, "1021": 0.05970508232712746, "1026": 0.13670019805431366, "1039": 0.757441520690918, "1048": 0.26296505331993103, "1052": 0.1970241367816925, "2001": 0.025073638185858727, "2034": 0.22704219818115234, "2035": 0.5579402446746826, "2039": 0.06520967930555344, "2044": 0.15442965924739838, "20... | 21048969 | OBJECTIVE To evaluate the association between vascular inflammation as measured by subacute C-reactive protein (CRP; 1-10 mg/l) and all-cause mortality and the association between change in CRP status (normal <or=3 mg/l and elevated >3 mg/l) and all-cause mortality. METHODS Probabilistic record linkage was used to matc... | Evaluation of the association between the first observation and the longitudinal change in C-reactive protein, and all-cause mortality. |
{"1017": 0.0842406153678894, "2000": 0.2822965085506439, "2001": 0.2969166338443756, "2003": 0.20102575421333313, "2015": 0.10731173306703568, "2038": 0.04113444685935974, "2042": 0.0019512200960889459, "2062": 0.026025565341114998, "2073": 0.0913962796330452, "2085": 0.3723714053630829, "2088": 0.34300774335861206, "2... | 21050357 | Despite the success of safe sleep campaigns and the progress in understanding risk factors, the rate of reduction in the cases of sudden infant death syndrome has now slowed and it remains a leading cause of postneonatal mortality in many developed countries. Strategic action is needed to tackle this problem and it is ... | Research Priorities in Sudden Unexpected Infant Death: An International Consensus. |
{"1011": 0.16690383851528168, "1014": 0.48430517315864563, "1039": 0.6348392367362976, "1047": 0.02887592278420925, "1052": 0.42608439922332764, "1054": 0.20977331697940826, "1999": 0.15860503911972046, "2003": 0.0058422754518687725, "2054": 0.05970508232712746, "2062": 0.14349138736724854, "2109": 0.28670501708984375,... | 21053753 | The Constant-Murley shoulder assessment score has proven to be a valuable diagnostic instrument. Thus, in the literature it has been mentioned that the clinical accuracy of this score varies especially when comparing patients in larger, inhomogeneous patient groups. The "relative Constant score" (CS(rel)) tries to mini... | Modification of the Constant-Murley shoulder score-introduction of the individual relative Constant score Individual shoulder assessment. |
{"1003": 0.07341018319129944, "1011": 0.10906458646059036, "1013": 0.23479416966438293, "1016": 0.26146242022514343, "1043": 0.5685047507286072, "1045": 0.8057082891464233, "1056": 0.23402166366577148, "1998": 0.04860413447022438, "2000": 0.01934296265244484, "2005": 0.2954642176628113, "2007": 0.38308101892471313, "20... | 21060008 | OBJECTIVE To assay the efficiency for celiac disease (CD) screening of 2 immunochromatographic visual stick assays based on human recombinant tissue transglutaminase (tTG). One was the antitissue transglutaminase antibodies (AtTGA) stick for IgA/G antibodies to tTG detection, the other was the AtTGA/antigliadin antibod... | Celiac disease screening by immunochromatographic visual assays: results of a multicenter study. |
{"1018": 0.22937409579753876, "1040": 0.3777405619621277, "1047": 1.0540125370025635, "1051": 0.7426811456680298, "2007": 0.21135559678077698, "2029": 0.15442965924739838, "2035": 0.06154331564903259, "2039": 0.14264501631259918, "2060": 0.12470348179340363, "2064": 0.2622140049934387, "2089": 0.34300774335861206, "209... | 21063817 | AIMS This study aimed to identify relevant keratin subtypes that may associate with the pathogenesis of oral epithelial neoplasms. METHODS AND RESULTS Expression of all the keratin subtypes was examined by cDNA microarray analysis of 43 oral squamous cell carcinoma (OSCC) cases. Immunohistochemical expression of the ma... | Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis. |
{"1011": 0.129004567861557, "1020": 0.016465263441205025, "2000": 0.08603433519601822, "2002": 0.43623676896095276, "2004": 0.5104349255561829, "2008": 0.05046287178993225, "2015": 0.4286321699619293, "2024": 0.10993985831737518, "2029": 0.20660123229026794, "2050": 0.1930064558982849, "2072": 0.015504186972975731, "20... | 21093407 | Abiotic and biotic stressors in human cells are often a result of sudden and/or frequent changes in environmental factors. The molecular response to stress involves elaborate modulation of gene expression and is of homeostatic, ecological, and evolutionary importance. Although attention has primarily focused on signali... | Identification of short-lived long non-coding RNAs as surrogate indicators for chemical stress response. |
{"1011": 0.07431721687316895, "1017": 0.0752234235405922, "1021": 0.19381128251552582, "1043": 0.48430517315864563, "1047": 0.6410312056541443, "1048": 0.9944084882736206, "1062": 0.5855054259300232, "1998": 0.08154398202896118, "2004": 0.00875066313892603, "2005": 0.11343330889940262, "2007": 0.036437395960092545, "20... | 21108759 | We have identified and characterized the gene for a novel zinc finger transcription factor which we have termed lung Krüppel-like factor (LKLF). LKLF was isolated through the use of the zinc finger domain of erythroid Krüppel-like factor (ELKF) as a hybridization probe and is closely related to this erythroid cell-spec... | Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. |
{"1015": 0.0354953333735466, "1018": 0.255429208278656, "1042": 0.28155985474586487, "1048": 0.4770587682723999, "1049": 0.5347557663917542, "1052": 0.026976587250828743, "2003": 0.25694093108177185, "2011": 0.18573370575904846, "2029": 0.012615402229130268, "2033": 0.02316705882549286, "2064": 0.3127557039260864, "207... | 21114100 | Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder often characterized by severe neurodevelopmental abnormalities and neuro-retinal degeneration. Mutations in the TRPML1 gene are causative for MLIV. We used lead optimization strategies to identify--and MLIV patient fibroblasts to test--sm... | A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. |
{"1015": 0.1358480453491211, "1021": 0.4126010537147522, "1038": 0.011650617234408855, "1039": 0.2478361576795578, "1040": 0.06977381557226181, "1043": 0.6446255445480347, "1164": 0.1485546976327896, "1999": 0.0174254160374403, "2003": 0.1477125883102417, "2005": 0.49923527240753174, "2008": 0.040196798741817474, "2011... | 21141798 | The murine monoclonal antibody (MAb) 18B7 [immunoglobulin G1(kappa)] is in preclinical development for treatment of Cryptococcus neoformans infections. In anticipation of its use in humans, we defined the serological and biological properties of MAb 18B7 in detail. Structural comparison to the related protective MAb 2H... | Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies. |
{"1011": 0.15526613593101501, "1016": 0.8135309815406799, "1043": 0.4462870955467224, "1051": 0.75193190574646, "2003": 0.11865071207284927, "2005": 0.3519764244556427, "2006": 0.8332487344741821, "2007": 0.24631060659885406, "2047": 0.11430477350950241, "2048": 0.4374985992908478, "2050": 0.3262358605861664, "2057": 0... | 21150010 | Metastatic ovarian cancer is the leading cause of death among women with gynecologic malignancies in the United States. The lack of effective treatment for patients with advanced ovarian cancer warrants development of innovative therapies. Cancer therapy using oncolytic viruses represents a promising new approach for c... | Treatment with cyclooxygenase-2 inhibitors enables repeated administration of vaccinia virus for control of ovarian cancer. |
{"1011": 0.24325250089168549, "1016": 0.6793810129165649, "1017": 0.8272887468338013, "1038": 0.011650617234408855, "1039": 0.25995752215385437, "1043": 0.6043586730957031, "1056": 0.13925230503082275, "1155": 0.37102460861206055, "1156": 0.04207121208310127, "2003": 0.0058422754518687725, "2004": 0.9546096324920654, "... | 21164071 | Integrins are membrane receptors which mediate cell-cell or cell-matrix adhesion. Integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) acts as a fibrinogen receptor of platelets and mediates platelet aggregation. Platelet activation is required for alpha IIb beta 3 to shift from noncompetent to competent for binding solub... | Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. |
{"1011": 0.18167030811309814, "1015": 0.15023678541183472, "1996": 0.02887592278420925, "1998": 0.01934296265244484, "2007": 0.1994270235300064, "2012": 0.14264501631259918, "2015": 0.6960725784301758, "2028": 0.009718249551951885, "2029": 0.39762192964553833, "2043": 0.1808556467294693, "2048": 0.14095009863376617, "2... | 21170174 | During meiosis, recombination between homologous chromosomes generates crossover (CR) and noncrossover (NCR) products. CRs establish connections between homologs, whereas intermediates leading to NCRs have been proposed to participate in homologous pairing. How these events are differentiated and regulated remains to b... | Crossover and noncrossover pathways in mouse meiosis. |
{"1011": 0.22937409579753876, "1050": 0.7086513638496399, "1164": 0.13157635927200317, "1997": 0.3381449282169342, "1998": 0.06337817758321762, "2005": 0.029824240133166313, "2007": 0.2637155055999756, "2008": 0.11343330889940262, "2011": 0.3560888469219208, "2029": 0.4248080551624298, "2071": 0.15777134895324707, "207... | 21179714 | Inhibitor-of-Apoptosis (IAP) proteins contribute to tumor progression, but the requirements of this pathway are not understood. Here, we show that intermolecular cooperation between XIAP and survivin stimulates tumor cell invasion and promotes metastasis. This pathway is independent of IAP inhibition of cell death. Ins... | IAP regulation of metastasis. |
{"1009": 0.4734157919883728, "1016": 0.16607704758644104, "1041": 1.04512357711792, "1043": 0.16690383851528168, "1052": 0.3241194784641266, "1999": 0.006812678650021553, "2007": 0.12470348179340363, "2011": 0.3269403576850891, "2029": 0.34577593207359314, "2063": 0.9739698171615601, "2064": 0.040196798741817474, "2076... | 21181273 | Prostaglandin E2 (PGE2) can stimulate tumor progression by modulating several proneoplastic pathways, including proliferation, angiogenesis, cell migration, invasion, and apoptosis. Although steady-state tissue levels of PGE2 stem from relative rates of biosynthesis and breakdown, most reports examining PGE2 have focus... | 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. |
{"1009": 0.7124901413917542, "1011": 0.06886265426874161, "1018": 0.21687394380569458, "1039": 0.013579257763922215, "1043": 0.6317287683486938, "1056": 0.997294545173645, "2005": 0.16359257698059082, "2011": 0.3241194784641266, "2029": 0.3163207769393921, "2036": 0.45251765847206116, "2071": 0.11430477350950241, "2124... | 21185923 | CD25+CD4+ regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family–related gene (GITR, also known as TNFRSF18)—a member of the tumor necrosis factor–nerve growth factor (TNF-NGF) receptor gene supe... | Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance |
{"1003": 0.05970508232712746, "1038": 0.24171993136405945, "1052": 0.43875885009765625, "1056": 0.05694137513637543, "1999": 0.0019512200960889459, "2001": 0.08064348995685577, "2040": 0.026976587250828743, "2043": 0.2105647772550583, "2047": 0.5478278398513794, "2060": 0.06154331564903259, "2073": 0.18492233753204346,... | 21186109 | Low case detection rates of new smear-positive pulmonary tuberculosis (PTB) patients globally are a cause for concern. The aim of this study was to determine for patients registered for TB in Malawi the number and percentage who lived in a neighbouring country and the registration, recording and reporting practices for... | The missing cases of tuberculosis in Malawi: the contribution from cross-border registrations. |
{"1011": 0.014542185701429844, "1017": 0.09317722171545029, "1018": 0.36426326632499695, "1022": 0.015504186972975731, "1037": 0.13925230503082275, "1039": 0.40871503949165344, "1041": 0.7665573358535767, "1042": 0.6286086440086365, "1044": 0.04394211992621422, "1050": 0.006812678650021553, "1052": 0.7755908370018005, ... | 21199527 | PTH binding to its receptor activates protein kinase A (PKA), protein kinase C (PKC), and calcium signaling to induce transcription of primary response genes in osteoblasts. Adenovirus E4 promoter-binding protein/nuclear factor regulated by IL-3 (E4BP4/NFIL3), a transcriptional repressor, is a PTH-induced primary respo... | Parathyroid hormone induces E4bp4 messenger ribonucleic acid expression primarily through cyclic adenosine 3',5'-monophosphate signaling in osteoblasts. |
{"1037": 0.11256109178066254, "1041": 0.1751343309879303, "1050": 0.04394211992621422, "1057": 0.05694137513637543, "2003": 0.28963330388069153, "2054": 0.010684899985790253, "2063": 0.014542185701429844, "2064": 0.10993985831737518, "2071": 0.1212492436170578, "2079": 0.32058215141296387, "2090": 0.18816383183002472, ... | 21203899 | Kidney donor exchanges enable recipients with immunologically incompatible donors to receive compatible living donor grafts; however, the financial management of these exchanges, especially when an organ is shipped, is complex and thus has the potential to impede the broader implementation of donor exchange programs. R... | Managing finances of shipping living donor kidneys for donor exchanges. |
{"1003": 0.022212404757738113, "1011": 0.14179791510105133, "1014": 0.17922431230545044, "1022": 1.0901126861572266, "1026": 0.03831886500120163, "1044": 0.9123768210411072, "1048": 0.3723714053630829, "1052": 0.37035053968429565, "1058": 0.011650617234408855, "2001": 0.021256839856505394, "2002": 0.39893341064453125, ... | 21216726 | Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 infection among human immunodeficiency virus (HIV)-infected and high-risk HIV-uninfected women. Serological tests with noninduced (latent) and induced (lytic) HHV-8 antigens were ... | Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women. |
{"1011": 0.20739519596099854, "1017": 0.2749055027961731, "1019": 0.1930064558982849, "1039": 0.7333439588546753, "1043": 0.2689530849456787, "1047": 0.8450632095336914, "1050": 0.04674193635582924, "1052": 0.4891071021556854, "1997": 0.14264501631259918, "1999": 0.10555581003427505, "2007": 0.1358480453491211, "2008":... | 21219071 | Neuronal Cdc2-like kinase (Nclk) is involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics. The active kinase consists of a catalytic subunit, Cdk5, and a 25 kDa activator protein (p25nck5a) derived from a 35 kDa neuronal-specific protein (p35nck5a). As an extension of our previous study... | Cloning of three novel neuronal Cdk5 activator binding proteins. |
{"1011": 0.319873183965683, "1017": 0.13414156436920166, "1025": 0.006812678650021553, "1047": 0.1685553640127182, "1052": 0.9045027494430542, "1997": 0.040196798741817474, "2000": 0.022212404757738113, "2003": 0.14179791510105133, "2005": 0.1913948506116867, "2008": 0.02316705882549286, "2011": 0.4067663550376892, "20... | 21221346 | In eukaryotic cells, nonhomologous DNA end joining (NHEJ) is a major pathway for repair of double-strand DNA breaks (DSBs). Artemis and the 469kDa DNA-dependent protein kinase (DNA-PKcs) together form a key nuclease for NHEJ in vertebrate organisms. The structure-specific endonucleolytic activity of Artemis is activate... | The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. |
{"1043": 0.09050461649894714, "1056": 0.6950984001159668, "1058": 0.2711893916130066, "2003": 0.33115679025650024, "2008": 0.0913962796330452, "2011": 0.14939609169960022, "2013": 0.01934296265244484, "2020": 0.0038986403960734606, "2024": 0.00875066313892603, "2029": 0.15359249711036682, "2030": 0.43244171142578125, "... | 21230110 | Taro bacilliform virus (TaBV) is a pararetrovirus of the genus Badnavirus which infects the monocotyledonous plant, taro (Colocasia esculenta). A region of the TaBV genome spanning nucleotides 6,281 to 12 (T1200), including the 3′ end of open reading frame 3 (ORF 3) and the intergenic region to the end of the tRNAmet-b... | A promoter derived from taro bacilliform badnavirus drives strong expression in transgenic banana and tobacco plants |
{"1016": 0.10379679501056671, "1017": 0.2674594223499298, "1019": 0.22392450273036957, "1022": 0.3084607720375061, "1051": 0.7067264318466187, "2020": 0.13499516248703003, "2043": 0.4248080551624298, "2044": 0.14602625370025635, "2046": 0.052318159490823746, "2048": 0.10467668622732162, "2050": 0.7105726003646851, "205... | 21232018 | We investigated the capacity of young ovaries, transplanted into old ovariectomized CBA mice, to improve remaining life expectancy of the hosts. Donor females were sexually mature 2-month-olds; recipients were prepubertally ovariectomized at 3 weeks and received transplants at 5, 8 or 11 months of age. Relative to ovar... | Age of ovary determines remaining life expectancy in old ovariectomized mice. |
{"1014": 0.3423145115375519, "1045": 0.6197150945663452, "1052": 0.5635144114494324, "2005": 0.12384103983640671, "2015": 0.03925827145576477, "2034": 0.13243216276168823, "2043": 0.2954642176628113, "2044": 0.46670228242874146, "2051": 0.4764525294303894, "2053": 0.1946154683828354, "2064": 0.004870930220931768, "2072... | 21239672 | OBJECTIVE To assess the association between use of macrolide antibiotics in mothers and infants from pregnancy onset until 120 days after birth and infantile hypertrophic pyloric stenosis (IHPS). DESIGN Nationwide register based cohort study. SETTING Denmark, 1996-2011. PARTICIPANTS 999,378 liveborn singletons and link... | Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study |
{"2003": 0.02316705882549286, "2007": 0.2852376699447632, "2011": 0.020300358533859253, "2015": 0.06246116757392883, "2031": 0.13414156436920166, "2050": 0.10026945173740387, "2055": 0.02887592278420925, "2060": 0.1477125883102417, "2064": 0.06520967930555344, "2066": 0.1384023278951645, "2089": 0.0019512200960889459, ... | 21246752 | OBJECTIVE Mitochondrial disorders are caused by gene mutations in mitochondrial or nuclear DNA and affect energy-dependent organs such as the brain. Patients with psychiatric illness, particularly those with medical comorbidities, may have primary mitochondrial disorders. To date, this issue has received little attenti... | The psychiatric manifestations of mitochondrial disorders: a case and review of the literature. |
{"1011": 0.2247048318386078, "1047": 0.0317181795835495, "1157": 0.47827014327049255, "1999": 0.015504186972975731, "2004": 1.1846466064453125, "2005": 0.10203468054533005, "2007": 0.05417001247406006, "2008": 0.0009760859538801014, "2011": 0.15023678541183472, "2012": 0.11343330889940262, "2015": 0.24631060659885406, ... | 21250322 | Interfering with the activity of polo-like kinases can lead to the formation of monopolar spindles. Polo-like kinases also regulate mitotic entry, activation of the anaphase-promoting complex and the necessary preconditions for cytokinesis. Similarities between the phenotypes of the Drosophila mutants asp and polo poin... | Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes |
{"1011": 0.04207121208310127, "1043": 0.5685047507286072, "1048": 0.1619328260421753, "2001": 0.12642613053321838, "2004": 0.09672962874174118, "2011": 0.15023678541183472, "2022": 0.04860413447022438, "2042": 0.06520967930555344, "2043": 0.030771657824516296, "2049": 0.3170322775840759, "2051": 0.4337083101272583, "20... | 21257564 | The paramount feature of long-term potentiation (LTP) as a memory mechanism is its characteristic persistence over time. Although the basic phenomenology of LTP persistence was established 30 years ago, new insights have emerged recently about the extent of LTP persistence and its regulation by activity and experience.... | How long will long-term potentiation last? |
{"1011": 0.41195443272590637, "1016": 0.39762192964553833, "1017": 0.11168810725212097, "1018": 0.3027053773403168, "1045": 0.05694137513637543, "1056": 0.5139457583427429, "1999": 0.04113444685935974, "2002": 0.6118015646934509, "2005": 0.009718249551951885, "2015": 0.129004567861557, "2029": 0.13755162060260773, "206... | 21258863 | In schistosomiasis, chronic parasite egg-induced granuloma formation can lead to tissue destruction and fibrosis, which causes much of the morbidity and mortality associated with this disease. Here we show the importance of IL-13 in the pathogenesis of schistosomiasis, and demonstrate, perhaps for the first time, the t... | An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. |
{"1016": 0.0058422754518687725, "1057": 0.11168810725212097, "1998": 0.06154331564903259, "2001": 0.2696990668773651, "2015": 0.8315495252609253, "2020": 0.175953671336174, "2034": 0.3864043951034546, "2043": 0.24631060659885406, "2044": 0.33953672647476196, "2045": 0.11604541540145874, "2048": 0.5506471395492554, "205... | 21260231 | The validity and reliability of observational methods for studying medication administration errors (MAEs) were studied. Between January and June 1998, two pharmacists observed consecutive drug administration rounds by nurses on two wards in a U.K. hospital and recorded all MAEs identified. The observers intervened in ... | Validity and reliability of observational methods for studying medication administration errors. |
{"1011": 0.255429208278656, "1018": 0.4481603503227234, "1039": 0.34922540187835693, "1047": 0.6719275116920471, "1060": 0.3170322775840759, "2010": 0.6317287683486938, "2011": 0.2837681770324707, "2013": 0.1718502640724182, "2015": 1.0305955410003662, "2025": 0.06520967930555344, "2026": 0.7791815400123596, "2029": 0.... | 21271817 | Ectopic expression of the four transcription factors Oct4, Sox2, c-Myc, and Klf4 is sufficient to confer a pluripotent state upon the fibroblast genome, generating induced pluripotent stem (iPS) cells. It remains unknown if nuclear reprogramming induced by these four factors globally resets epigenetic differences betwe... | Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. |
{"1041": 0.17020416259765625, "1996": 0.26146242022514343, "2008": 0.022212404757738113, "2029": 0.30558720231056213, "2035": 0.04113444685935974, "2046": 0.03831886500120163, "2060": 0.07612881064414978, "2073": 0.012615402229130268, "2099": 0.5601736903190613, "2112": 0.043007105588912964, "2116": 0.04580953717231750... | 21272977 | This review summarizes our current understanding of exocrine pancreas development, including the formation of acinar, ductal and centroacinar cells. We discuss the transcription factors associated with various stages of exocrine differentiation, from multipotent progenitor cells to fully differentiated acinar and ducta... | Exocrine ontogenies: on the development of pancreatic acinar, ductal and centroacinar cells. |
{"1015": 0.08603433519601822, "1020": 0.013579257763922215, "1052": 0.4879087805747986, "1058": 0.20739519596099854, "2008": 0.0174254160374403, "2011": 0.05417001247406006, "2013": 0.4926934838294983, "2015": 0.07159364968538284, "2031": 0.06977381557226181, "2038": 0.1332872211933136, "2042": 0.31560876965522766, "20... | 21274496 | Simian immunodeficiency virus (SIV) naturally infects non-human primates in Africa. To date, 40 SIVs have been described both in natural hosts and in heterologous species. These viruses are highly diverse and the majority cluster in 6 relatively equidistant phylogenetic lineages. At least 8 SIVs are currently considere... | The history of SIVS and AIDS: epidemiology, phylogeny and biology of isolates from naturally SIV infected non-human primates (NHP) in Africa. |
{"1998": 0.037378571927547455, "2007": 0.29109421372413635, "2035": 0.12470348179340363, "2045": 0.34508460760116577, "2049": 0.09584271162748337, "2064": 0.056018441915512085, "2104": 0.6400018334388733, "2111": 0.5151132941246033, "2119": 0.026976587250828743, "2128": 0.06703783571720123, "2174": 0.14433705806732178,... | 21274919 | OBJECTIVE Chronic physical comorbidity is common in dementia. However, there is an absence of evidence to support good practice guidelines for attention to these problems. We aimed to study the extent of this comorbidity and its impact on cognitive function and disability in population-based studies in low and middle i... | The association between common physical impairments and dementia in low and middle income countries, and, among people with dementia, their association with cognitive function and disability. A 10/66 Dementia Research Group population-based study. |
{"1011": 0.05786345899105072, "1014": 0.35334911942481995, "1020": 0.45437926054000854, "1022": 0.4337083101272583, "1023": 0.6902132034301758, "1026": 0.10906458646059036, "1052": 0.45499902963638306, "1054": 0.46914875507354736, "1056": 0.4624064862728119, "1998": 0.06429435312747955, "2004": 0.06795065850019455, "20... | 21287352 | BACKGROUND Recent studies show that COPD patients exhibit low-grade systemic inflammation, and that plasma fibrinogen and high neutrophil counts are related to faster declines in lung function. We examined correlations between serum biomarkers and the decline of lung function in COPD patients. METHOD Baseline levels of... | Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease. |
{"1011": 0.18167030811309814, "1017": 0.42990362644195557, "1019": 0.4920966327190399, "1047": 0.47463157773017883, "1052": 0.4041621685028076, "1996": 0.1212492436170578, "2005": 0.0354953333735466, "2008": 0.0770333781838417, "2011": 0.41840189695358276, "2012": 0.31204116344451904, "2029": 0.25088030099868774, "2066... | 21295300 | The phosphatidylinositol-3-kinase-like kinase ATM (ataxia-telangiectasia mutated) has a central role in coordinating DNA damage responses, including cell-cycle checkpoint control, DNA repair and apoptosis. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer predisposition. However, the... | Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death |
{"1011": 0.09672962874174118, "1041": 0.1221139207482338, "1043": 0.037378571927547455, "1048": 0.49030399322509766, "1050": 0.5370414853096008, "1051": 0.3547199070453644, "1999": 0.2394166737794876, "2004": 0.25845035910606384, "2005": 0.14602625370025635, "2011": 0.0797421783208847, "2012": 0.07884006202220917, "202... | 21297708 | 1. Nitric oxide (NO) has been suggested as a gastrointestinal neurotransmitter, mediating the gastric receptive relaxation and the relaxation in the peristaltic reflex. The aim of the present study was to measure nerve-induced NO formation in vivo in the gastrointestinal tract. 2. Formation of the nitric oxide oxidatio... | Nerve-induced release of nitric oxide in the rabbit gastrointestinal tract as measured by in vivo microdialysis. |
{"1003": 0.25239890813827515, "1023": 0.0038986403960734606, "2001": 0.16607704758644104, "2018": 0.1384023278951645, "2019": 0.5573811531066895, "2020": 0.2659635543823242, "2031": 0.020300358533859253, "2042": 0.2637155055999756, "2047": 0.4400174915790558, "2060": 0.21135559678077698, "2064": 0.03925827145576477, "2... | 21301090 | BACKGROUND Patients considered for arterial surgery, have been shown to have a high incidence of coexistent cardiac, vascular and other diseases, affecting operative risk and survival. We developed a systematic workup strategy for detecting these coexistent diseases in our vascular surgical patients, mainly based on no... | Screening for concomitant diseases in peripheral vascular patients. Results of a systematic approach. |
{"1054": 0.13157635927200317, "2007": 0.43623676896095276, "2012": 0.02316705882549286, "2020": 0.31489628553390503, "2022": 0.6533012986183167, "2037": 0.2659635543823242, "2044": 0.3810817003250122, "2065": 0.09584271162748337, "2076": 0.3930181860923767, "2086": 0.08154398202896118, "2087": 0.007782140281051397, "20... | 21302115 | OBJECTIVE To assess if family care givers of patients with lung cancer experience the patterns of social, psychological, and spiritual wellbeing and distress typical of the patient, from diagnosis to death. DESIGN Secondary analysis of serial qualitative interviews carried out every three months for up to a year or to ... | Archetypal trajectories of social, psychological, and spiritual wellbeing and distress in family care givers of patients with lung cancer: secondary analysis of serial qualitative interviews |
{"1011": 0.31560876965522766, "1016": 0.6000806093215942, "1050": 0.13925230503082275, "1052": 1.018678069114685, "1057": 0.30558720231056213, "2006": 0.4419025182723999, "2007": 0.1946154683828354, "2011": 0.38308101892471313, "2014": 1.19888174533844, "2025": 0.04113444685935974, "2029": 0.24631060659885406, "2048": ... | 21307488 | HER-2/neu amplification or overexpression can make cancer cells resistant to apoptosis and promotes their growth. p53 is crucial in regulating cell growth and apoptosis, and is often mutated or deleted in many types of tumour. Moreover, many tumours with a wild-type gene for p53 do not have normal p53 function, suggest... | HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation |
{"1056": 1.243794322013855, "2011": 0.3070250153541565, "2043": 0.10379679501056671, "2076": 0.14179791510105133, "2079": 0.16276304423809052, "2114": 0.08692999184131622, "2122": 0.04860413447022438, "2129": 0.45994341373443604, "2188": 0.319873183965683, "2278": 0.48008447885513306, "2339": 0.39696553349494934, "2433... | 21320417 | T cell memory induced by prior infection or vaccination provides enhanced protection against subsequent microbial infections. The processes involved in generating and maintaining T cell memory are becoming better understood due to recent technological advances in identifying memory T cells and monitoring their behavior... | T cell memory. |
{"1014": 0.304147332906723, "1016": 0.3070250153541565, "1017": 0.21530038118362427, "1051": 0.11951763927936554, "1052": 0.29255300760269165, "1997": 0.09228714555501938, "2001": 0.05046287178993225, "2019": 0.17759032547473907, "2046": 0.045809537172317505, "2058": 0.3750596046447754, "2072": 0.10291612148284912, "20... | 21323587 | Objectives: To study the change in outcome for patients admitted to an intensive care unit following the establishment of a team of resident medical staff and a change from an "open" to a "closed" organisational format. Design: Database review of prospectively collected data. Setting: Intensive care unit of a postgradu... | The impact of organisational change on outcome in an intensive care unit in the United Kingdom |
{"1011": 0.04487626627087593, "1020": 0.18654440343379974, "1056": 0.42926809191703796, "2003": 0.42990362644195557, "2004": 0.14179791510105133, "2005": 0.16359257698059082, "2012": 0.8459017872810364, "2034": 0.4151833653450012, "2042": 0.05786345899105072, "2043": 0.030771657824516296, "2044": 0.151916041970253, "20... | 21323758 | Tafamidis is a transthyretin (TTR) stabilizer able to prevent TTR tetramer dissociation. There have been a few encouraging studies on Tafamidis efficacy in early-onset inherited transthyretin amyloidosis (ATTR) due to Val30Met mutation. However, less is known about its efficacy in later disease stages and in non-Val30M... | Monitoring effectiveness and safety of Tafamidis in transthyretin amyloidosis in Italy: a longitudinal multicenter study in a non-endemic area |
{"1011": 0.23247487843036652, "1054": 0.16607704758644104, "1996": 0.4879087805747986, "1999": 0.055094651877880096, "2008": 0.0913962796330452, "2014": 0.2184450328350067, "2015": 0.33115679025650024, "2024": 0.09672962874174118, "2029": 0.23324857652187347, "2075": 0.2852376699447632, "2076": 0.37707099318504333, "20... | 21330280 | Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its regulation. Whereas most RNP enzymes are stable in composition and harbor preformed active sites, the spliceosome, which removes noncoding introns from precursor messenger RNAs (pre-mRNAs), follows fundamentally different strategie... | The Spliceosome: Design Principles of a Dynamic RNP Machine |
{"1011": 0.4462870955467224, "1015": 0.7124901413917542, "1018": 0.15023678541183472, "1020": 0.32129061222076416, "1038": 0.8845420479774475, "1047": 0.5133614540100098, "1048": 0.2231435477733612, "1056": 1.0144377946853638, "2011": 0.175953671336174, "2012": 0.23787821829319, "2028": 0.36494144797325134, "2029": 0.2... | 21363424 | T cell-specific deletion of Blimp-1 causes abnormal T cell homeostasis and function, leading to spontaneous, fatal colitis in mice. Herein we explore the role of Blimp-1 in Th1/Th2 differentiation. Blimp-1 mRNA and protein are more highly expressed in Th2 cells compared with Th1 cells, and Blimp-1 attenuates IFN-gamma ... | Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression. |
{"1006": 0.05046287178993225, "1009": 0.53589928150177, "1011": 0.040196798741817474, "1015": 0.0019512200960889459, "1016": 0.5596157908439636, "1017": 0.3547199070453644, "1018": 0.0354953333735466, "1038": 0.48430517315864563, "1039": 0.8567397594451904, "1044": 0.4093637466430664, "1048": 0.36426326632499695, "1056... | 21366394 | Allergic asthma is a T helper type 2 (T(H)2)-dominated disease of the lung. In people with asthma, a fraction of CD4(+) T cells express the CX3CL1 receptor, CX3CR1, and CX3CL1 expression is increased in airway smooth muscle, lung endothelium and epithelium upon allergen challenge. Here we found that untreated CX3CR1-de... | CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung |
{"1020": 0.6931471824645996, "1040": 0.034552380442619324, "1043": 0.6813592314720154, "1052": 0.012615402229130268, "1056": 0.06886265426874161, "2003": 0.3241194784641266, "2029": 0.021256839856505394, "2091": 0.020300358533859253, "2094": 0.09317722171545029, "2121": 0.1510767638683319, "2177": 0.3269403576850891, "... | 21369472 | Progressive kidney failure is a genetically and clinically heterogeneous group of disorders. Podocyte foot processes and the interposed glomerular slit diaphragm are essential components of the permeability barrier in the kidney. Mutations in genes encoding structural proteins of the podocyte lead to the development of... | TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function |
{"1011": 0.11430477350950241, "1015": 0.7755908370018005, "1044": 0.2231435477733612, "1999": 0.08603433519601822, "2003": 0.0009760859538801014, "2005": 0.0009760859538801014, "2007": 0.2493593990802765, "2008": 0.014542185701429844, "2012": 0.8109301924705505, "2026": 0.04207121208310127, "2028": 0.4574742913246155, ... | 21372171 | Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator. A previous study suggested that fibrinogen is an important factor associated with a... | Usefulness of high mobility group box 1 protein as a plasma biomarker in patient with peripheral artery disease. |
{"1011": 0.037378571927547455, "1052": 0.13071982562541962, "1996": 0.0317181795835495, "1997": 0.18329764902591705, "2003": 0.15359249711036682, "2005": 0.10026945173740387, "2008": 0.07431721687316895, "2013": 0.15023678541183472, "2015": 0.1994270235300064, "2020": 0.07250232994556427, "2024": 0.4067663550376892, "2... | 21373240 | Proteins of the Argonaute family are small RNA carriers that guide regulatory complexes to their targets. The family comprises two major subclades. Members of the Ago subclade, which are present in most eukaryotic phyla, bind different classes of small RNAs and regulate gene expression at both transcriptional and post-... | Functional specialization of Piwi proteins in Paramecium tetraurelia from post-transcriptional gene silencing to genome remodelling |
{"1009": 0.06977381557226181, "1014": 0.1212492436170578, "1017": 0.22704219818115234, "1018": 0.026025565341114998, "1020": 0.2034190446138382, "1022": 0.20977331697940826, "1040": 0.3381449282169342, "1044": 0.2881702482700348, "1050": 0.6410312056541443, "1052": 0.41840189695358276, "1054": 0.7220231294631958, "1999... | 21373821 | A series of 33 patients with combined (injurious) sleepwalking, sleep terrors, and rapid eye movement (REM) sleep behavior disorder (viz. "parasomnia overlap disorder") was gathered over an 8-year period. Patients underwent clinical and polysomnographic evaluations. Mean age was 34 +/- 14 (SD) years; mean age of paraso... | A parasomnia overlap disorder involving sleepwalking, sleep terrors, and REM sleep behavior disorder in 33 polysomnographically confirmed cases. |
{"1014": 0.4093637466430664, "1020": 0.16690383851528168, "1043": 0.043007105588912964, "1053": 0.18492233753204346, "1609": 0.3325583338737488, "1997": 0.18978065252304077, "2004": 0.0029254043474793434, "2041": 0.3027053773403168, "2109": 0.680370569229126, "2116": 0.28450319170951843, "2119": 0.021256839856505394, "... | 21377587 | BACKGROUND Patient experience is increasingly used to assess organizational performance, for example in public reporting or pay-for-performance schemes. Conventional approaches using 95% confidence intervals are commonly used to determine required survey samples or to report performance but these may result in unreliab... | How can health care organizations be reliably compared?: Lessons from a national survey of patient experience. |
{"1040": 0.07431721687316895, "1062": 0.6317287683486938, "1999": 0.17922431230545044, "2001": 0.016465263441205025, "2008": 0.05139094591140747, "2011": 0.3662964701652527, "2015": 0.10906458646059036, "2029": 0.25845035910606384, "2033": 0.23015019297599792, "2035": 0.13071982562541962, "2036": 0.11430477350950241, "... | 21380232 | Mouse embryos undergo genome-wide methylation reprogramming by demethylation in early preimplantation development, followed by remethylation thereafter. Here we show that genome-wide reprogramming is conserved in several mammalian species and ask whether it also occurs in embryos cloned with the use of highly methylate... | Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. |
{"1037": 0.7009293437004089, "1040": 0.7463917136192322, "1041": 0.9576126337051392, "1047": 0.7276995778083801, "1056": 0.1734936386346817, "1155": 0.5723689198493958, "1997": 0.1384023278951645, "1998": 0.0842406153678894, "1999": 0.255429208278656, "2000": 0.3870677351951599, "2002": 0.4980490207672119, "2004": 0.13... | 21380348 | Vitamins are compounds that are essential for the normal growth, reproduction and functioning of the human body. Of the 13 known vitamins, vitamins A, D, E and K are lipophilic compounds and are therefore called fat-soluble vitamins. Because of their lipophilicity, fat-soluble vitamins are solubilized and transported b... | Intracellular transport of fat-soluble vitamins A and E. |
{"1009": 0.3409265875816345, "1011": 0.11081436276435852, "1017": 0.09228714555501938, "1019": 0.36426326632499695, "1044": 0.5472630262374878, "1052": 0.6543170213699341, "1155": 0.5098485946655273, "2000": 0.21214580535888672, "2005": 0.3870677351951599, "2007": 0.3269403576850891, "2011": 0.31560876965522766, "2029"... | 21382907 | Targeting of αVβ3 and αVβ5 integrins by cilengitide may reduce growth of solid tumors including head and neck squamous cell carcinoma (HNSCC). Preclinical investigations suggest increased activity of cilengitide in combination with other treatment modalities. The only published trial in HNSCC (ADVANTAGE) investigated c... | Reduced Cytokine Release in Ex Vivo Response to Cilengitide and Cetuximab Is a Marker for Improved Survival of Head and Neck Cancer Patients |
{"1049": 0.5973974466323853, "2005": 0.34715715050697327, "2011": 0.4349733293056488, "2013": 0.15860503911972046, "2026": 1.0907690525054932, "2030": 0.3318578004837036, "2033": 0.24401791393756866, "2060": 0.2969166338443756, "2064": 0.12556517124176025, "2079": 0.14518201351165771, "2088": 0.3353555500507355, "2090"... | 21383026 | Despite over a century of research, tuberculosis remains a leading cause of infectious death worldwide. Faced with increasing rates of drug resistance, the identification of genes that are required for the growth of this organism should provide new targets for the design of antimycobacterial agents. Here, we describe t... | Genes required for mycobacterial growth defined by high density mutagenesis. |
{"1011": 0.05694137513637543, "1017": 0.1946154683828354, "1039": 0.1751343309879303, "1040": 0.36358460783958435, "2003": 0.018384648486971855, "2005": 0.25694093108177185, "2013": 0.3930181860923767, "2015": 0.4914994537830353, "2024": 0.14095009863376617, "2029": 0.1401015669107437, "2064": 0.1477125883102417, "2073... | 21387297 | Cardiovascular disease is a leading cause of death worldwide. The limited capability of heart tissue to regenerate has prompted methodological developments for creating de novo cardiomyocytes, both in vitro and in vivo. Beyond uses in cell replacement therapy, patient-specific cardiomyocytes may find applications in dr... | Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. |
{"1009": 0.4556184411048889, "1011": 0.175953671336174, "1019": 0.10379679501056671, "1022": 0.34300774335861206, "1038": 0.4537591338157654, "1039": 0.5336109399795532, "1048": 0.6833335757255554, "1056": 0.7473171949386597, "1999": 0.0913962796330452, "2008": 0.0174254160374403, "2029": 0.4041621685028076, "2035": 0.... | 21392223 | Expression of the receptor-type tyrosine phosphatase LAR was studied in cells of the murine hemopoietic system. The gene is expressed in all cells of the T cell lineage but not in cells of any other hemopoietic lineage and the level of expression in T cells is developmentally regulated. The CD4(-)8(-)44(+) early thymic... | Within the hemopoietic system, LAR phosphatase is a T cell lineage-specific adhesion receptor-like protein whose phosphatase activity appears dispensable for T cell development, repertoire selection and function. |
{"1999": 0.34577593207359314, "2004": 0.469759464263916, "2011": 0.014542185701429844, "2035": 0.3374483287334442, "2037": 0.27786844968795776, "2061": 0.512191891670227, "2062": 0.14939609169960022, "2079": 0.35403475165367126, "2089": 0.03925827145576477, "2090": 0.6543170213699341, "2125": 0.8143964409828186, "2129"... | 21392703 | All organisms must trade off resource allocation between different life processes that determine their survival and reproduction. Malaria parasites replicate asexually in the host but must produce sexual stages to transmit between hosts. Because different specialized stages are required for these functions, the divisio... | Competition and the evolution of reproductive restraint in malaria parasites. |
{"1022": 0.0770333781838417, "1039": 0.34300774335861206, "1040": 0.04953393340110779, "1051": 0.46363574266433716, "1052": 0.21922965347766876, "1998": 0.1808556467294693, "2003": 0.4145384132862091, "2015": 0.1384023278951645, "2029": 0.14686977863311768, "2054": 0.27342069149017334, "2061": 0.17020416259765625, "209... | 21395936 | Chronic obstructive pulmonary disease (COPD) is a chronic airway disorder characterized by obstructive airflow limitation which is not completely reversible with treatment. Inflammatory changes in the peripheral airways, especially those with the diameter less than 2mm (so-called small airway disease) have been specula... | [Neutrophils and macrophages related to the pathogenesis and disease development of chronic obstructive pulmonary disease by the inflammatory reaction]. |
{"1011": 0.1510767638683319, "1015": 0.66441810131073, "1038": 0.49030399322509766, "1039": 0.2018241584300995, "1041": 0.12814582884311676, "1056": 1.0887986421585083, "1155": 0.1889725625514984, "1156": 0.49923527240753174, "1999": 0.009718249551951885, "2003": 0.2607102394104004, "2007": 0.13925230503082275, "2008":... | 21414718 | Trefoil factor family 1 (TFF1) is a member of the TFF-domain peptide family involved in epithelial restitution and cell motility. Recently, we screened Piezo1 as a candidate TFF1-binding protein. We aimed to confirm Piezo1 as a novel TFF1 binding protein and to assess the role of this interaction in mediating gastric c... | Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro |
{"1011": 0.11256109178066254, "1015": 0.22859740257263184, "1043": 0.9005423784255981, "1050": 0.2749055027961731, "1052": 0.22548456490039825, "1999": 0.304147332906723, "2003": 0.03831886500120163, "2004": 0.23402166366577148, "2005": 0.21214580535888672, "2008": 0.08692999184131622, "2011": 0.09317722171545029, "202... | 21425864 | Glycosyl phosphatidylinositols (GPIs) anchor many proteins to the surface of eukaryotic cells and may also serve as sorting signals on proteins and participate in signal transduction. We have isolated a Saccharomyces cerevisiae GPI anchoring mutant, gpi1, using a colony screen for cells blocked in [3H]inositol incorpor... | A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis. |
{"1019": 0.40806588530540466, "1021": 0.026025565341114998, "1996": 0.04394211992621422, "2003": 0.006812678650021553, "2005": 0.08064348995685577, "2011": 0.4337083101272583, "2015": 0.29036402702331543, "2047": 0.2711893916130066, "2064": 0.49030399322509766, "2071": 0.06795065850019455, "2079": 0.23633737862110138, ... | 21439293 | Pattern recognition by the innate immune system enables the detection of microorganisms, but how the level of microbial threat is evaluated — a process that is crucial for eliciting measured antimicrobial responses with minimal inflammatory tissue damage — is less well understood. New evidence has shown that features o... | Beyond pattern recognition: five immune checkpoints for scaling the microbial threat |
{"1011": 0.304147332906723, "1015": 0.17267228662967682, "1016": 0.5990082025527954, "1041": 0.02412080205976963, "1045": 0.6654226183891296, "1052": 0.3177432417869568, "2007": 0.20818853378295898, "2011": 0.15943801403045654, "2012": 0.3134697377681732, "2020": 0.029824240133166313, "2029": 0.16276304423809052, "2048... | 21439640 | Tumor-associated macrophages and high levels of cyclooxygenase-2 (COX-2) are associated with poor prognosis in breast cancer patients, but their potential interdependence has not been evaluated. The objective of this study was to determine whether macrophages regulate COX-2 expression in breast cancer cells. For this p... | Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification. |
{"1004": 0.15777134895324707, "1006": 0.04487626627087593, "1011": 0.014542185701429844, "1043": 1.1121915578842163, "1997": 0.04207121208310127, "1998": 0.5816917419433594, "2004": 0.025073638185858727, "2005": 0.12728634476661682, "2015": 0.7791815400123596, "2029": 0.1970241367816925, "2033": 0.5528968572616577, "20... | 21456232 | Induced pluripotent stem cells (iPSCs) hold great promise as a cell source for regenerative medicine yet its culture, maintenance of pluripotency and induction of differentiation remain challenging. Conversely, graphene (G) and graphene oxide (GO) have captured tremendous interests in the fields of materials science, p... | A graphene-based platform for induced pluripotent stem cells culture and differentiation. |
{"1016": 0.44753631949424744, "1051": 0.14602625370025635, "1052": 0.15023678541183472, "1054": 0.026976587250828743, "1058": 0.5506471395492554, "1060": 0.0058422754518687725, "2058": 0.48430517315864563, "2076": 0.2763880789279938, "2082": 0.3241194784641266, "2084": 0.32199856638908386, "2086": 0.1619328260421753, "... | 21459247 | Our purpose was to determine the aerobic capacities (VO2max) of a group of black female adolescents (age = 11.4-15.8 years) randomly chosen from a single urban school. Of 91 girls selected, 64 performed an incremental treadmill running test to volitional exhaustion and achieved VO2max as determined from expired gas mea... | Aerobic capacity in black adolescent girls. |
{"1011": 0.2493593990802765, "1017": 0.623910129070282, "1047": 0.6823468804359436, "1048": 0.40481385588645935, "1052": 0.2576959431171417, "1054": 0.4041621685028076, "1056": 0.8682814836502075, "1057": 0.18654440343379974, "2005": 0.025073638185858727, "2008": 0.03925827145576477, "2011": 0.37707099318504333, "2012"... | 21465696 | Post-translational modifications of Notch3 and their functional role with respect to Notch3 overexpression in T-cell leukemia are still poorly understood. We identify here a specific novel property of Notch3 that is acetylated and deacetylated at lysines 1692 and 1731 by p300 and HDAC1, respectively, a balance impaired... | Acetylation controls Notch3 stability and function in T-cell leukemia |
{"1003": 0.1229778528213501, "1009": 0.10555581003427505, "1014": 0.38041436672210693, "1015": 0.26146242022514343, "1020": 0.058784693479537964, "1021": 0.39893341064453125, "1022": 0.026976587250828743, "1026": 0.41195443272590637, "1028": 0.3923587501049042, "1043": 0.5244048833847046, "1044": 0.7656494975090027, "1... | 21472388 | OBJECTIVE To determine the frequency of moderate and severe hypoglycemia and to identify clinical predictors associated with its occurrence in a large population-based sample of children and adolescents with IDDM. RESEARCH DESIGN AND METHODS A total of 657 patients (age: 12.1 +/- 4.4 years, mean +/- SD) were included i... | Hypoglycemia: incidence and clinical predictors in a large population-based sample of children and adolescents with IDDM. |
{"1009": 0.23633737862110138, "1017": 0.01934296265244484, "1018": 0.20022670924663544, "1020": 0.6522845029830933, "1021": 0.43244171142578125, "1023": 0.2561853528022766, "1050": 0.2881702482700348, "1052": 0.37907835841178894, "2000": 0.0038986403960734606, "2001": 0.06154331564903259, "2005": 0.17759032547473907, "... | 21479231 | RATIONALE The outcome of fully intermittent thrice-weekly antituberculosis treatment of various durations in HIV-associated tuberculosis is unclear. OBJECTIVES To compare the efficacy of an intermittent 6-month regimen (Reg6M: 2EHRZ(3)/4HR(3) [ethambutol, 1,200 mg; isoniazid, 600 mg; rifampicin, 450 or 600 mg depending... | Efficacy of a 6-month versus 9-month intermittent treatment regimen in HIV-infected patients with tuberculosis: a randomized clinical trial. |
{"1011": 0.08692999184131622, "1022": 0.27342069149017334, "1039": 0.09850110858678818, "1052": 0.5461324453353882, "1053": 0.00875066313892603, "1054": 0.3519764244556427, "2008": 0.0174254160374403, "2020": 0.0797421783208847, "2024": 0.27564704418182373, "2029": 0.3134697377681732, "2041": 0.1734936386346817, "2042"... | 21479575 | Mouse pluripotent stem cells (PSCs) are the best studied pluripotent system and are regarded as the "gold standard" to which human PSCs are compared. However, while the genomic integrity of human PSCs has recently drawn much attention, mouse PSCs have not been systematically evaluated in this regard. The genomic stabil... | High prevalence of evolutionarily conserved and species-specific genomic aberrations in mouse pluripotent stem cells. |
{"1011": 0.45251765847206116, "1038": 0.12814582884311676, "1041": 0.5701626539230347, "1042": 0.7592713832855225, "1052": 0.012615402229130268, "2003": 0.22157983481884003, "2004": 0.22859740257263184, "2011": 0.3949938118457794, "2026": 0.8195732831954956, "2029": 0.2317005842924118, "2044": 0.42608439922332764, "204... | 21487212 | Ex-FABP, an extracellular fatty acid binding lipocalin, is physiologically expressed by differentiating chicken chondrocytes and myoblasts. Its expression is enhanced after cell treatment with inflammatory stimuli and repressed by anti-inflammatory agents, behaving as an acute phase protein. Chicken liver fragments in ... | Inhibition of cell proliferation and induction of apoptosis by ExFABP gene targeting. |
{"1050": 0.2493593990802765, "1996": 0.04767346754670143, "2001": 0.22859740257263184, "2003": 0.16442140936851501, "2015": 0.8534175157546997, "2040": 0.06612417846918106, "2043": 0.3269403576850891, "2048": 0.1477125883102417, "2050": 0.49626702070236206, "2073": 0.4412745535373688, "2093": 0.09317722171545029, "2094... | 21489324 | Located in the Kassena-Nankana districts of northern Ghana, the Navrongo health and demographic surveillance system (NHDSS) was established in 1992 by the Navrongo health research centre (NHRC). The NHRC is one of three research centres of the Ghana health service. The activities and potential of the NHDSS for collabor... | Profile of the Navrongo Health and Demographic Surveillance System. |
{"1003": 0.19220098853111267, "1018": 0.3177432417869568, "1057": 0.49030399322509766, "1997": 0.18816383183002472, "2038": 0.036437395960092545, "2040": 0.43875885009765625, "2045": 0.07250232994556427, "2055": 0.020300358533859253, "2058": 0.06795065850019455, "2061": 0.006812678650021553, "2069": 0.00195122009608894... | 21495419 | Information on the prevalence of COPD was obtained from vital statistics, health interview surveys, hospital charge records, national publications, and the World Health Organization (WHO). These data indicate that COPD is a common disease with implications for global health. In the United States, morbidity caused by CO... | The impact of COPD on lung health worldwide: epidemiology and incidence. |
{"1009": 0.7267557382583618, "1011": 0.2696990668773651, "1015": 0.24554696679115295, "1040": 0.13670019805431366, "1048": 0.255429208278656, "1056": 0.9936857223510742, "2007": 0.08871890604496002, "2011": 0.42735910415649414, "2025": 0.11604541540145874, "2029": 0.2539152204990387, "2039": 0.3127557039260864, "2044":... | 21498497 | Leprosy enables investigation of mechanisms by which the innate immune system contributes to host defense against infection, because in one form, the disease progresses, and in the other, the infection is limited. We report that Toll-like receptor (TLR) activation of human monocytes induces rapid differentiation into t... | TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells |
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