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{"1016": 0.9005423784255981, "1021": 0.17431432008743286, "1043": 0.35128939151763916, "1055": 0.7220231294631958, "1062": 1.0087559223175049, "2005": 0.4734157919883728, "2029": 0.24171993136405945, "2043": 0.1332872211933136, "2048": 0.5528968572616577, "2051": 0.04953393340110779, "2076": 0.14518201351165771, "2084"... | 30915421 | In this study, we observed the effects of metformin, one of the most widely prescribed drugs for the treatment of type 2 diabetes, on cell proliferation and neuroblast differentiation in the subgranular zone of the hippocampal dentate gyrus (SZDG) in Zucker diabetic fatty (ZDF) rats, which are a model for type 2 diabet... | Metformin Normalizes Type 2 Diabetes-Induced Decrease in Cell Proliferation and Neuroblast Differentiation in the Rat Dentate Gyrus |
{"1999": 0.034552380442619324, "2003": 0.1718502640724182, "2004": 0.6027565002441406, "2013": 0.06520967930555344, "2022": 0.07431721687316895, "2042": 0.02316705882549286, "2043": 0.1384023278951645, "2051": 0.36494144797325134, "2064": 0.22392450273036957, "2069": 0.0174254160374403, "2071": 0.10818854719400406, "20... | 30919024 | Evidence suggests that dormant, microscopic tumors are not only common, but are highly prevalent in otherwise healthy individuals. Due to their small size and non-invasive nature, these dormant tumors remain asymptomatic and, in most cases, undetected. With advances in diagnostic imaging and molecular biology, it is no... | Molecular mechanisms underlying tumor dormancy. |
{"1009": 0.8400169610977173, "1011": 0.25845035910606384, "1044": 0.27712854743003845, "1999": 0.12470348179340363, "2002": 0.1229778528213501, "2008": 0.07612881064414978, "2011": 0.37974658608436584, "2026": 0.8383291959762573, "2029": 0.3554046154022217, "2043": 0.18329764902591705, "2044": 0.24171993136405945, "204... | 30933307 | It is generally accepted that, following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency in CD34(+) progenitor cells and other derivative cells of the myeloid lineage. In this study, we show that the viral UL144 gene is expressed during latent infection in two cell types of the myeloid line... | The myeloid transcription factor GATA-2 regulates the viral UL144 gene during human cytomegalovirus latency in an isolate-specific manner. |
{"1011": 0.4330752193927765, "1039": 1.0023250579833984, "1040": 0.40089741349220276, "1044": 0.21293537318706512, "1056": 0.9139442443847656, "1998": 0.12728634476661682, "2003": 0.15860503911972046, "2005": 0.21214580535888672, "2007": 0.16524957120418549, "2012": 0.1905880719423294, "2029": 0.040196798741817474, "20... | 30981192 | Lowering low-density lipoprotein-cholesterol (LDL-C) is the primary target in the management of dyslipidemia in patients at high risk of cardiovascular disease. However, patients who have achieved LDL-C levels below the currently recommended targets may still experience cardiovascular events. This may result, in part, ... | How to control residual cardiovascular risk despite statin treatment: focusing on HDL-cholesterol. |
{"1003": 0.2105647772550583, "1014": 0.6639154553413391, "1015": 0.7220231294631958, "1016": 0.6400018334388733, "1021": 0.24248650670051575, "1043": 0.6260011196136475, "1044": 0.7038320899009705, "2001": 0.007782140281051397, "2007": 0.16442140936851501, "2028": 0.3519764244556427, "2044": 0.006812678650021553, "2048... | 30983338 | AIMS/HYPOTHESIS We assessed the association between congenital malformations and maternal hyperglycemia in pregnant women with pregestational (type 1 or type 2) diabetes and investigated if the rate of congenital malformations was similar in women with near-normal glycemic control compared to the background population.... | The prevalence of congenital malformations is still higher in pregnant women with pregestational diabetes despite near-normal HbA1c: a literature review. |
{"1011": 0.23092569410800934, "1016": 0.4926934838294983, "1020": 0.7038320899009705, "1038": 0.4914994537830353, "1042": 0.09406650811433792, "1044": 0.6202403903007507, "1047": 0.24171993136405945, "1050": 1.0101795196533203, "1164": 0.7510106563568115, "1999": 0.06795065850019455, "2002": 0.8298473954200745, "2011":... | 31001322 | We show that NF-kappaB and transcriptional targets are activated in liver by obesity and high-fat diet (HFD). We have matched this state of chronic, subacute 'inflammation' by low-level activation of NF-kappaB in the liver of transgenic mice, designated LIKK, by selectively expressing constitutively active IKK-b in hep... | Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. |
{"2012": 0.0913962796330452, "2013": 0.10026945173740387, "2037": 0.15275461971759796, "2054": 0.06337817758321762, "2061": 0.014542185701429844, "2065": 0.010684899985790253, "2079": 0.13670019805431366, "2108": 0.25694093108177185, "2111": 0.817850649356842, "2116": 0.35334911942481995, "2166": 0.21293537318706512, "... | 31019903 | Homelessness affects tens of thousands of canadians and has important health implications. Homeless people are at increased risk of dying prematurely and suffer from a wide range of health problems, including seizures, chronic obstructive pulmonary disease, musculoskeletal disorders, tuberculosis, and skin and foot pro... | Homelessness and health. |
{"2005": 0.06429435312747955, "2015": 0.016465263441205025, "2022": 0.01934296265244484, "2042": 0.08244366943836212, "2064": 0.2089812457561493, "2070": 0.15943801403045654, "2071": 0.013579257763922215, "2075": 0.3877306580543518, "2079": 0.12814582884311676, "2109": 0.7565253376960754, "2116": 0.08603433519601822, "... | 31070360 | PURPOSE OF REVIEW The aim of this study is to highlight some recent uses of serum metabolomics in human and animal studies. The main themes are the importance of understanding the underlying variation in human metabolism and the use of serum metabolomics in disease profiling. RECENT FINDINGS Several studies have attemp... | Serum metabolomics in animal models and human disease. |
{"1011": 0.2223619967699051, "1015": 0.3995884954929352, "1038": 0.7124901413917542, "1039": 0.11430477350950241, "1043": 1.1089750528335571, "1050": 0.4950772523880005, "1056": 0.6492279767990112, "1996": 0.030771657824516296, "2002": 0.4932899475097656, "2003": 0.07793712615966797, "2005": 0.16690383851528168, "2007"... | 31107919 | G protein-coupled receptors (GPCRs) from the secretin-like (class B) family are key players in hormonal homeostasis and are important drug targets for the treatment of metabolic disorders and neuronal diseases. They consist of a large N-terminal extracellular domain (ECD) and a transmembrane domain (TMD) with the GPCR ... | Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors. |
{"1011": 0.38574060797691345, "1017": 0.21687394380569458, "1042": 0.41065993905067444, "1044": 0.8989537954330444, "1055": 0.058784693479537964, "1999": 0.05139094591140747, "2002": 0.11430477350950241, "2011": 0.23402166366577148, "2015": 0.7592713832855225, "2029": 0.21530038118362427, "2073": 0.058784693479537964, ... | 31141365 | Using mouse skin, where bountiful reservoirs of synchronized hair follicle stem cells (HF-SCs) fuel cycles of regeneration, we explore how adult SCs remodel chromatin in response to activating cues. By profiling global mRNA and chromatin changes in quiescent and activated HF-SCs and their committed, transit-amplifying ... | Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage. |
{"1041": 0.04113444685935974, "1050": 0.2160874605178833, "1996": 0.04860413447022438, "1997": 0.13755162060260773, "1999": 0.06246116757392883, "2005": 0.04674193635582924, "2011": 0.24401791393756866, "2015": 0.5506471395492554, "2029": 0.15359249711036682, "2041": 0.06520967930555344, "2050": 0.3743882179260254, "20... | 31148090 | Endogenous small RNAs function in RNA interference (RNAi) pathways to guide RNA cleavage, translational repression, or methylation of DNA or chromatin. In Tetrahymena thermophila, developmentally regulated DNA elimination is governed by an RNAi mechanism involving approximately 27-30-nucleotide (nt) RNAs. Here we chara... | Two classes of endogenous small RNAs in Tetrahymena thermophila. |
{"1011": 0.3283478021621704, "1015": 0.13157635927200317, "1040": 0.3777405619621277, "1047": 0.4574742913246155, "1997": 0.11865071207284927, "1999": 0.06612417846918106, "2002": 0.6624060273170471, "2003": 0.21372433006763458, "2011": 0.01934296265244484, "2015": 0.1602703034877777, "2024": 0.34300774335861206, "2029... | 31154082 | Dehydrins (DHNs; late embryogenesis abundant D-11) are a family of plant proteins induced in response to abiotic stresses such as drought, low temperature, and salinity or during the late stages of embryogenesis. Spectral and thermal properties of these proteins in purified form suggest that they are "intrinsically uns... | The binding of maize DHN1 to lipid vesicles. Gain of structure and lipid specificity. |
{"1011": 0.045809537172317505, "1015": 0.0913962796330452, "1020": 0.2394166737794876, "1996": 0.08244366943836212, "1997": 0.018384648486971855, "2005": 0.15359249711036682, "2007": 0.1221139207482338, "2015": 0.25694093108177185, "2025": 0.25088030099868774, "2029": 0.28963330388069153, "2043": 0.3141832649707794, "2... | 31166180 | Centromeres are heterochromatic in many organisms, but the mitotic function of this silent chromatin remains unknown. During cell division, newly replicated sister chromatids must cohere until anaphase when Scc1/Rad21-mediated cohesion is destroyed. In metazoans, chromosome arm cohesins dissociate during prophase, leav... | Requirement of heterochromatin for cohesion at centromeres. |
{"1011": 0.650757372379303, "1014": 0.6867793202400208, "1028": 0.24325250089168549, "1053": 0.10203468054533005, "1054": 0.9769153594970703, "2000": 0.018384648486971855, "2005": 0.07612881064414978, "2007": 0.11691460013389587, "2011": 0.07250232994556427, "2013": 0.06520967930555344, "2029": 0.18816383183002472, "20... | 31200375 | The reverse transcriptase-polymerase chain reaction (RT-PCR) method has lately become widely used to determine transcription and mRNA content in rodent and human muscle samples. However, the common use of endogenous controls for correcting for variance in cDNA between samples is not optimal. Specifically, we investigat... | Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsies |
{"1011": 0.0606246218085289, "1014": 0.4151833653450012, "1043": 0.5701626539230347, "1052": 0.4914994537830353, "1053": 0.969535231590271, "1054": 0.5795059204101562, "1058": 0.7510106563568115, "1081": 0.009718249551951885, "1997": 0.176772341132164, "2007": 0.11951763927936554, "2039": 0.11517547070980072, "2050": 0... | 31208367 | PURPOSE To evaluate the association between rates of progressive loss in different regions of the visual field and longitudinal changes in quality of life (QoL). DESIGN Prospective, observational cohort study. PARTICIPANTS The study included 236 patients with glaucomatous visual field loss followed for an average of 4.... | The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma. |
{"1003": 0.06977381557226181, "1014": 0.5324648022651672, "1016": 0.8459017872810364, "1052": 0.34577593207359314, "1062": 0.025073638185858727, "2005": 0.176772341132164, "2007": 0.22704219818115234, "2029": 0.11778303235769272, "2048": 0.38041436672210693, "2050": 0.16524957120418549, "2053": 0.6907027959823608, "206... | 31229233 | BACKGROUND Patients with type 2 diabetes have a 40% increased risk of bladder cancer. Thiazolidinediones, especially pioglitazone, may increase the risk. We conducted a systematic review and meta-analysis to evaluate the risk of bladder cancer among adults with type 2 diabetes taking thiazolidinediones. METHODS We sear... | Use of thiazolidinediones and the risk of bladder cancer among people with type 2 diabetes: a meta-analysis. |
{"1011": 0.42416930198669434, "1045": 0.3897167444229126, "1048": 0.5568217039108276, "1054": 1.301234245300293, "1996": 0.13243216276168823, "2005": 0.09228714555501938, "2007": 0.1619328260421753, "2008": 0.04767346754670143, "2015": 0.3346569836139679, "2024": 0.06154331564903259, "2029": 0.2409527748823166, "2050":... | 31272411 | The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect viral RNA ligands or processed self RNA in the cytoplasm to trigger innate immunity and inflammation and to impart gene expression that serves t... | Immune signaling by RIG-I-like receptors. |
{"1038": 0.07793712615966797, "1042": 0.39433568716049194, "1052": 0.5381823778152466, "1056": 0.23710809648036957, "2000": 0.259204238653183, "2038": 0.06429435312747955, "2042": 0.18329764902591705, "2050": 0.17840765416622162, "2051": 0.14686977863311768, "2064": 0.151916041970253, "2071": 0.3910386264324188, "2076"... | 31293581 | Exposure to IR has been shown to induce the formation of senescence markers, a phenotype that coincides with lifelong delayed repair and regeneration of irradiated tissues. We hypothesized that IR-induced senescence markers could persist long-term in vivo, possibly contributing to the permanent reduction in tissue func... | Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. |
{"1037": 0.02887592278420925, "1996": 0.6739205718040466, "1997": 0.11604541540145874, "2013": 0.020300358533859253, "2029": 0.06795065850019455, "2033": 0.6719275116920471, "2054": 0.020300358533859253, "2073": 0.08154398202896118, "2075": 0.5255602598190308, "2076": 0.05046287178993225, "2079": 0.21687394380569458, "... | 31304956 | Head development in vertebrates involves a complex series of molecular and morphogenetic events that generate a coordinated pattern of cartilages, bones and nerves, and result in species-specific craniofacial morphologies. A specialized cell type of neural origin, the neural crest, is central to this process, as it pro... | Cranial neural crest and the building of the vertebrate head |
{"1011": 0.21135559678077698, "1021": 0.01934296265244484, "1039": 0.15693697333335876, "1041": 0.5990082025527954, "2007": 0.17840765416622162, "2026": 0.48068851232528687, "2029": 0.06429435312747955, "2033": 0.6773988008499146, "2064": 0.12642613053321838, "2076": 0.056018441915512085, "2078": 0.5318912267684937, "2... | 31311495 | We have previously demonstrated that, following acquisition of endocrine resistance, breast cancer cells display an altered growth rate together with increased aggressive behaviour in vitro. Since dysfunctional cell-cell adhesive interactions can promote an aggressive phenotype, we investigated the integrity of this pr... | Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation. |
{"1011": 0.043007105588912964, "1014": 0.38308101892471313, "1017": 0.1401015669107437, "1021": 0.10379679501056671, "1023": 0.06612417846918106, "1048": 0.37102460861206055, "1052": 0.5827828645706177, "1056": 0.9394577741622925, "2007": 0.11081436276435852, "2012": 0.1693800985813141, "2029": 0.3106105625629425, "203... | 31313782 | Patients with idiopathic pulmonary fibrosis (IPF) have a higher incidence of lung cancer. The role of Toll-like receptors (TLRs), a key component of the innate immunity, in interstitial lung diseases (ILDs) and lung cancer pathogenesis is not clarified. TLR2, TLR3, TLR4, TLR7, TLR8 a... | Expression profiles of Toll-like receptors in non-small cell lung cancer and idiopathic pulmonary fibrosis. |
{"1037": 0.6517757177352905, "1062": 0.12384103983640671, "2003": 0.42608439922332764, "2011": 0.07068414986133575, "2024": 0.4330752193927765, "2050": 0.26296505331993103, "2072": 0.7610978484153748, "2147": 0.06520967930555344, "2166": 0.0842406153678894, "2220": 0.013579257763922215, "2287": 0.5936289429664612, "229... | 31324978 | Progerias are rare genetic diseases characterized by premature aging. Several progeroid disorders are caused by mutations that lead to the accumulation of a lipid-modified (farnesylated) form of prelamin A, a protein that contributes to the structural scaffolding for the cell nucleus. In progeria, the accumulation of f... | A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. |
{"1019": 0.4203280806541443, "1022": 0.37907835841178894, "1043": 0.23787821829319, "1056": 0.7537717819213867, "1156": 0.48610860109329224, "2002": 0.32553088665008545, "2008": 0.08154398202896118, "2029": 0.23556606471538544, "2118": 0.0842406153678894, "2155": 0.3027053773403168, "2179": 0.14518201351165771, "2193":... | 31347396 | We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts (odds ratio = 2.15, Pmet... | A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death |
{"1019": 0.010684899985790253, "1022": 0.35950297117233276, "1050": 0.09317722171545029, "1054": 0.3141832649707794, "1998": 0.1064341589808464, "2001": 0.058784693479537964, "2005": 0.25467249751091003, "2007": 0.20580662786960602, "2012": 0.10818854719400406, "2020": 0.034552380442619324, "2043": 0.02887592278420925,... | 31363207 | BACKGROUND Patients with human immunodeficiency virus (HIV) infection and tuberculosis have an increased risk of death, treatment failure, and relapse. METHODS A systematic review and meta-analysis of randomized, controlled trials and cohort studies was conducted to evaluate the impact of duration and dosing schedule o... | Treatment of active tuberculosis in HIV-coinfected patients: a systematic review and meta-analysis. |
{"1011": 0.011650617234408855, "1017": 0.23092569410800934, "1043": 0.7592713832855225, "1045": 0.8349450826644897, "1996": 0.10203468054533005, "1997": 0.11865071207284927, "2008": 0.08961215615272522, "2011": 0.49686139822006226, "2012": 1.1437997817993164, "2024": 0.1994270235300064, "2029": 0.3615458607673645, "203... | 31387717 | Fast excitatory neurotransmission is mediated largely by ionotropic glutamate receptors (iGluRs), tetrameric, ligand-gated ion channel proteins comprised of three subfamilies, AMPA, kainate and NMDA receptors, with each subfamily sharing a common, modular-domain architecture. For all receptor subfamilies, active channe... | Crystal structure and association behaviour of the GluR2 amino-terminal domain. |
{"1011": 0.4126010537147522, "1017": 0.2918238639831543, "1041": 0.7710843086242676, "1047": 0.8813109993934631, "1048": 0.9363996982574463, "1055": 0.5947071313858032, "1997": 0.055094651877880096, "1999": 0.18816383183002472, "2003": 0.1064341589808464, "2007": 0.06612417846918106, "2008": 0.06795065850019455, "2011"... | 31407112 | The loss of the ability to deaminate l-serine severely impairs growth and cell division in Escherichia coli K-12. A strain from which the three genes (sdaA, sdaB, tdcG) coding for this organism's three l-serine deaminases had been deleted grows well in glucose minimal medium but, on subculture into minimal medium with ... | Deficiency in l-serine deaminase results in abnormal growth and cell division of Escherichia coli K-12. |
{"1006": 0.04860413447022438, "1009": 0.66441810131073, "1011": 0.16607704758644104, "1014": 0.6327666640281677, "1017": 0.3012613356113434, "1018": 0.30917787551879883, "1019": 0.38905516266822815, "1020": 0.5444341897964478, "1048": 0.52266925573349, "1999": 0.11343330889940262, "2004": 0.2659635543823242, "2005": 0.... | 31439189 | BACKGROUND Recent studies indicate the presence of a small, stem-like cell population in several human cancers that is crucial for the tumour (re)population. OBJECTIVE Six established prostate cancer (PCa) cell lines-DU145, DuCaP, LAPC-4, 22Rv1, LNCaP, and PC-3-were examined for their stem cell properties in vitro. DES... | Stem cell characteristics in prostate cancer cell lines. |
{"1017": 0.0770333781838417, "2000": 0.06703783571720123, "2001": 0.23710809648036957, "2004": 0.07431721687316895, "2021": 0.034552380442619324, "2037": 0.15860503911972046, "2038": 0.10993985831737518, "2042": 0.03831886500120163, "2043": 0.20102575421333313, "2045": 0.04953393340110779, "2052": 0.33325836062431335, ... | 31460499 | Overusing antibiotics is not the only cause and reducing use is not the only solution W arning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to appear in the middle of the last century, and by the 1990s various reports had signalled the dangers of excessive or inappropriate use of antib... | Resistance to antimicrobials in humans and animals. |
{"1043": 0.8748174905776978, "2020": 0.012615402229130268, "2037": 0.3241194784641266, "2052": 0.23479416966438293, "2060": 0.025073638185858727, "2064": 0.0038986403960734606, "2065": 0.14433705806732178, "2071": 0.29400965571403503, "2094": 0.7701805830001831, "2101": 0.1808556467294693, "2108": 0.04953393340110779, ... | 31495049 | Previous studies have found that declining health, decreased social interaction, and inadequate financial resources were significant risk factors for late-life depression, and social support from families and friends and religiosity were significant protective factors. In this study, we examined if low-income older adu... | Unmet needs and depressive symptoms among low--income older adults. |
{"1011": 0.3982778787612915, "1016": 0.011650617234408855, "1018": 0.0058422754518687725, "1021": 0.7592713832855225, "1054": 1.0601204633712769, "1996": 0.20421554148197174, "1997": 0.01934296265244484, "1999": 0.004870930220931768, "2000": 0.016465263441205025, "2002": 0.6291293501853943, "2003": 0.020300358533859253... | 31514338 | The eukaryotic replisome is a crucial determinant of genome stability, but its structure is still poorly understood. We found previously that many regulatory proteins assemble around the MCM2-7 helicase at yeast replication forks to form the replisome progression complex (RPC), which might link MCM2-7 to other replisom... | A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome. |
{"1016": 0.29400965571403503, "1041": 0.06795065850019455, "1053": 0.5662899017333984, "1056": 0.7115318179130554, "2000": 0.01934296265244484, "2003": 0.015504186972975731, "2007": 0.045809537172317505, "2013": 0.09584271162748337, "2029": 0.06246116757392883, "2047": 0.15023678541183472, "2048": 0.4196864068508148, "... | 31543713 | The recent development of microarray technology has led statisticians and bioinformaticians to develop new statistical methodologies for comparing different biological samples. The objective is to identify a small number of differentially expressed genes from among thousands. In quantitative proteomics, analysis of pro... | Data analysis methods for detection of differential protein expression in two-dimensional gel electrophoresis. |
{"1039": 0.053244512528181076, "1044": 0.15442965924739838, "1054": 0.5629584193229675, "2003": 0.33605360984802246, "2005": 0.24631060659885406, "2015": 0.004870930220931768, "2024": 0.2539152204990387, "2051": 0.19220098853111267, "2090": 0.21687394380569458, "2094": 0.6931471824645996, "2098": 0.022212404757738113, ... | 31554917 | Circadian rhythm sleep disorders are characterized by complaints of insomnia and excessive sleepiness that are primarily due to alterations in the internal circadian timing system or a misalignment between the timing of sleep and the 24-h social and physical environment. In addition to physiological and environmental f... | A clinical approach to circadian rhythm sleep disorders. |
{"1015": 0.38308101892471313, "1016": 0.23402166366577148, "1041": 0.23864774405956268, "1052": 0.259204238653183, "1054": 0.3416208028793335, "1055": 0.20421554148197174, "1058": 0.3784096837043762, "1999": 0.025073638185858727, "2003": 0.16690383851528168, "2008": 0.0009760859538801014, "2013": 0.15860503911972046, "... | 31560225 | In a prior report, we described the isolation and characterization of SIVrcm, a distinct primate lentivirus found in a household pet Red-Capped Mangabey (RCM) in Gabon. SIVrcm is divergent from HIV-1 and HIV-2/SIV families of primate lentiviruses. In this report, additional in vitro replication studies and the results ... | SIVrcm infection of macaques. |
{"2000": 0.2231435477733612, "2001": 0.026976587250828743, "2005": 0.04767346754670143, "2007": 0.3269403576850891, "2011": 0.07431721687316895, "2020": 0.07793712615966797, "2062": 0.1734936386346817, "2071": 0.030771657824516296, "2089": 0.06795065850019455, "2090": 0.04394211992621422, "2097": 0.08513788133859634, "... | 31562330 | BACKGROUND The increased caloric requirements of HIV-positive individuals, undesirable side effects of treatment that may be worsened by malnutrition (but alleviated by nutritional support), and associated declines in adherence and possible increased drug resistance are all justifications for developing better interven... | Integrating nutrition security with treatment of people living with HIV: lessons from Kenya. |
{"1011": 0.1751343309879303, "1016": 0.4248080551624298, "1043": 0.8715548515319824, "1048": 0.2394166737794876, "1054": 0.5180262327194214, "1056": 0.5903874635696411, "1999": 0.06520967930555344, "2006": 0.15943801403045654, "2029": 0.24171993136405945, "2048": 0.5290185213088989, "2094": 0.35334911942481995, "2119":... | 31564409 | Objectives:The orexigenic hormone ghrelin circulates mainly in two forms, acylated and desacyl ghrelin. We evaluated the impact of obesity and obesity-associated type 2 diabetes (T2D) on ghrelin forms and the potential role of acylated and desacyl ghrelin in the control of adipogenesis in humans. Methods:Plasma concent... | Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes |
{"1011": 0.04487626627087593, "1014": 0.31132611632347107, "1015": 0.07341018319129944, "1019": 0.32270604372024536, "1047": 0.19220098853111267, "1048": 0.8366385698318481, "1171": 0.42608439922332764, "1998": 0.07612881064414978, "1999": 0.025073638185858727, "2007": 0.06886265426874161, "2029": 0.38174858689308167, ... | 31591262 | The aim of the present study was to investigate whether the gene expression levels of LKB1 and LGR5 correlated with clinical outcome in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy (CRT). Residual cancer cells were obtained from 52 patients with locally advanced rectal cancer... | Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy |
{"1052": 0.21293537318706512, "2000": 0.03266380727291107, "2001": 0.175953671336174, "2007": 0.09761575609445572, "2020": 0.15526613593101501, "2031": 0.056018441915512085, "2038": 0.20739519596099854, "2042": 0.22937409579753876, "2043": 0.09672962874174118, "2079": 0.2763880789279938, "2086": 0.1994270235300064, "20... | 31612088 | Efforts to improve the outcomes of patients with mental illness often have involved incorporating the skills of a variety of health care professionals into collaborative care models. For over 30 years, clinical pharmacists have contributed to these care models in capacities ranging from educator to consultant to provid... | Evaluating the impact of pharmacists in mental health: a systematic review. |
{"1009": 0.4926934838294983, "1016": 0.2830325961112976, "1028": 0.28963330388069153, "2005": 0.28890204429626465, "2006": 0.026976587250828743, "2007": 0.02412080205976963, "2014": 1.1941591501235962, "2015": 0.567397952079773, "2029": 0.010684899985790253, "2030": 0.500420093536377, "2044": 0.48068851232528687, "2048... | 31616203 | PURPOSE Brain metastases develop in one third of patients with advanced HER2+ breast cancer. Effective therapy for patients with central nervous system (CNS) progression after cranial radiation is extremely limited and represents a major clinical challenge. Lapatinib, an epidermal growth factor receptor/HER2 inhibitor,... | Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. |
{"1015": 0.23092569410800934, "1040": 0.2539152204990387, "1052": 0.9754437208175659, "2008": 0.1677299439907074, "2011": 0.0174254160374403, "2029": 0.3409265875816345, "2050": 0.10906458646059036, "2076": 0.1970241367816925, "2079": 0.1677299439907074, "2083": 0.04860413447022438, "2099": 0.08064348995685577, "2119":... | 31624828 | The inefficient clearance of dying cells can lead to abnormal immune responses, such as unresolved inflammation and autoimmune conditions. We show that tumor suppressor p53 controls signaling-mediated phagocytosis of apoptotic cells through its target, Death Domain1α (DD1α), which suggests that p53 promotes both the pr... | Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53 |
{"1011": 0.02316705882549286, "1016": 0.43244171142578125, "1039": 0.07159364968538284, "2002": 0.15943801403045654, "2003": 0.20660123229026794, "2005": 0.2470736801624298, "2007": 0.03925827145576477, "2010": 0.7445381283760071, "2013": 0.10026945173740387, "2019": 0.42416930198669434, "2029": 0.0174254160374403, "20... | 31634628 | Cell-free tumor DNA (ctDNA) has the potential to enable non-invasive diagnostic tests for personalized medicine in providing similar molecular information as that derived from invasive tumor biopsies. The histology-independent phase II SHIVA trial matches patients with targeted therapeutics based on previous screening ... | Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types. |
{"1011": 0.3601844012737274, "1020": 0.9256220459938049, "1040": 0.3615458607673645, "1043": 0.30558720231056213, "1048": 0.3127557039260864, "1056": 1.061472773551941, "1156": 0.18004031479358673, "1999": 0.2822965085506439, "2005": 0.18573370575904846, "2008": 0.006812678650021553, "2010": 0.4487839937210083, "2011":... | 31682248 | Alterations of TGF-beta signaling have been described in colorectal cancer, although the molecular consequences are largely unknown. By using transgenic mice overexpressing TGF-beta or a dominant-negative TGF-betaRII, we demonstrate that TGF-beta signaling in tumor infiltrating T lymphocytes controls the growth of dysp... | TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. |
{"2003": 0.20660123229026794, "2005": 0.31132611632347107, "2008": 0.1332872211933136, "2024": 0.3170322775840759, "2052": 0.037378571927547455, "2054": 0.3519764244556427, "2064": 0.16442140936851501, "2070": 0.004870930220931768, "2071": 0.49030399322509766, "2079": 0.09761575609445572, "2102": 0.24325250089168549, "... | 31715818 | Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, carbon nanotubes, and polyplexes for the intracellular delivery of genes/oligonucleo... | New opportunities: the use of nanotechnologies to manipulate and track stem cells. |
{"1018": 0.42353010177612305, "1022": 0.3027053773403168, "1048": 0.19220098853111267, "1996": 0.24325250089168549, "1997": 0.02792670577764511, "2004": 0.02792670577764511, "2013": 0.13670019805431366, "2029": 0.12814582884311676, "2037": 0.12986256182193756, "2043": 0.175953671336174, "2046": 0.21214580535888672, "20... | 31761981 | During pupation, long-range order is imposed on the autonomously developing ommatidia which compose the Drosophila eye. To accomplish this, eight additional cell types arise: the primary, secondary, and tertiary pigment cells, and the four cells that form the bristle. These cells form an interweaving lattice between om... | The emergence of order in the Drosophila pupal retina. |
{"1011": 0.06429435312747955, "1039": 0.11604541540145874, "1051": 0.9052929878234863, "1056": 0.5033760666847229, "2003": 0.2409527748823166, "2011": 0.04953393340110779, "2029": 0.016465263441205025, "2044": 0.35745587944984436, "2046": 0.04207121208310127, "2048": 0.14095009863376617, "2051": 0.020300358533859253, "... | 31803596 | BACKGROUND Oral squamous cell carcinoma (OSCC) is common type of human cancer, but little is known about the molecular mechanisms deciding on this malignancy. Comprehensive gene expression profiling is essential for understanding OSCC. METHODS cDNA microarray was used to analyze expression patterns of 16 617 genes in n... | Gene expression analysis by cDNA microarray in oral squamous cell carcinoma. |
{"1020": 0.026025565341114998, "1022": 0.06429435312747955, "1043": 0.06795065850019455, "1044": 0.0913962796330452, "1047": 0.14349138736724854, "1054": 0.011650617234408855, "1057": 0.3757305145263672, "2005": 0.011650617234408855, "2007": 0.2160874605178833, "2022": 0.022212404757738113, "2030": 0.03831886500120163,... | 31834381 | BACKGROUND Although patients with gastroesophageal reflux are often instructed to change their lifestyle, population-based data on the risk factors for reflux in the United States are lacking. METHODS We performed a cross-sectional study in an age- and gender-stratified random sample of the population of Olmsted County... | Risk factors associated with symptoms of gastroesophageal reflux. |
{"1011": 0.12556517124176025, "1016": 0.5723689198493958, "1017": 0.10555581003427505, "1055": 0.20022670924663544, "1056": 0.4132472574710846, "1996": 0.03266380727291107, "2003": 0.05046287178993225, "2004": 0.2247048318386078, "2011": 0.08603433519601822, "2012": 0.10203468054533005, "2015": 0.9256220459938049, "202... | 31844040 | Two-component systems (TCSs) are widely employed by bacteria to sense specific external signals and conduct an appropriate response via a phosphorylation cascade within the cell. The TCS of the agr operon in the bacterium Staphylococcus aureus forms part of a regulatory process termed quorum sensing, a cell-to-cell com... | A mathematical investigation of the effects of inhibitor therapy on three putative phosphorylation cascades governing the two-component system of the agr operon. |
{"1041": 0.012615402229130268, "2003": 0.06886265426874161, "2004": 0.04953393340110779, "2005": 0.056018441915512085, "2011": 0.05786345899105072, "2014": 0.04953393340110779, "2015": 0.6773988008499146, "2024": 0.32764431834220886, "2029": 0.016465263441205025, "2048": 0.31560876965522766, "2050": 0.4041621685028076,... | 31851367 | Estrogens are key regulators of growth, differentiation, and the physiological functions of a wide range of target tissues, including the male and female reproductive tracts, breast, and skeletal, nervous, cardiovascular, digestive and immune systems. The majority of these biological activities of estrogens are mediate... | Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. |
{"1011": 0.07159364968538284, "1015": 0.23247487843036652, "1018": 0.8780695199966431, "1020": 0.053244512528181076, "1039": 0.3723714053630829, "1047": 0.7057625651359558, "1052": 0.4855078160762787, "2011": 0.41065993905067444, "2026": 0.9702757596969604, "2028": 0.012615402229130268, "2029": 0.3683255612850189, "203... | 31882215 | We describe robust induction of autophagy during the reprogramming of mouse fibroblasts to induced pluripotent stem cells by four reprogramming factors (Sox2, Oct4, Klf4 and c-Myc), henceforth 4F. This process occurs independently of p53 activation, and is mediated by the synergistic downregulation of mechanistic targe... | Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming |
{"1014": 0.07612881064414978, "1015": 0.8298473954200745, "1016": 0.16110190749168396, "1018": 0.004870930220931768, "2003": 0.17020416259765625, "2011": 0.02887592278420925, "2012": 0.8169882297515869, "2028": 0.43875885009765625, "2029": 0.011650617234408855, "2038": 0.13071982562541962, "2042": 0.08692999184131622, ... | 31884697 | Background Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder characterized by progressive motor and cognitive dysfunction. Caused by an expanded polyglutamine tract in ataxin 1 (ATXN1), SCA1 pathogenesis involves a multifactorial process that likely begins with misfolding of ATX... | Lithium Therapy Improves Neurological Function and Hippocampal Dendritic Arborization in a Spinocerebellar Ataxia Type 1 Mouse Model |
{"1019": 0.10731173306703568, "1025": 0.0029254043474793434, "1039": 0.05970508232712746, "1044": 0.8004589080810547, "1997": 0.07431721687316895, "1999": 0.21530038118362427, "2001": 0.14686977863311768, "2005": 0.25088030099868774, "2012": 0.472198486328125, "2020": 0.1734936386346817, "2026": 0.4728073179721832, "20... | 31889025 | OBJECTIVES - To study the relative and population-attributable risks of hypertension for the development of congestive heart failure (CHF), to assess the time course of progression from hypertension to CHF, and to identify risk factors that contribute to the development of overt heart failure in hypertensive subjects. ... | The progression from hypertension to congestive heart failure. |
{"1014": 0.37304413318634033, "1039": 0.7389566898345947, "1043": 0.4879087805747986, "1044": 0.08782484382390976, "1052": 0.4462870955467224, "1999": 0.1221139207482338, "2003": 0.2160874605178833, "2005": 0.010684899985790253, "2007": 0.28082266449928284, "2029": 0.10906458646059036, "2044": 0.42096930742263794, "207... | 31890716 | Resistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction. We investigated the association of plasma resistin with estimated glomerular filtration rate and albuminuria in 1575 hypertensive adults without known coronary heart disea... | Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults. |
{"1997": 0.14939609169960022, "2000": 0.06520967930555344, "2005": 0.14179791510105133, "2034": 0.1212492436170578, "2047": 0.053244512528181076, "2052": 0.14349138736724854, "2057": 0.058784693479537964, "2060": 0.11430477350950241, "2064": 0.021256839856505394, "2070": 0.23787821829319, "2071": 0.4580921530723572, "2... | 31902059 | Understanding the drivers of speciation is critical to interpreting patterns of biodiversity. The identification of the genetic changes underlying adaptation and reproductive isolation is necessary to link barriers to gene flow to the causal origins of divergence. Here, we present a novel approach to the genetics of sp... | Large-scale candidate gene scan reveals the role of chemoreceptor genes in host plant specialization and speciation in the pea aphid. |
{"1039": 0.5651806592941284, "2011": 0.2223619967699051, "2024": 0.03831886500120163, "2054": 0.37102460861206055, "2061": 0.8450632095336914, "2079": 0.1602703034877777, "2089": 0.15023678541183472, "2128": 0.36967599391937256, "2129": 0.14433705806732178, "2145": 0.05694137513637543, "2170": 0.45437926054000854, "221... | 31902335 | Common cancer theories hold that tumor is an uncontrolled somatic cell proliferation caused by the progressive addition of random mutations in critical genes that control cell growth. Nevertheless, various contradictions related to the mutation theory have been reported previously. These events may be elucidated by the... | The cancer stem cell hypothesis: a guide to potential molecular targets. |
{"1011": 0.29036402702331543, "1037": 0.8796916007995605, "1997": 0.07793712615966797, "1999": 0.16110190749168396, "2003": 0.037378571927547455, "2004": 0.018384648486971855, "2005": 0.14095009863376617, "2011": 0.2711893916130066, "2029": 0.1889725625514984, "2050": 1.2846163511276245, "2071": 0.09050461649894714, "2... | 31933981 | The synthesis of acute-phase protein serum amyloid A (SAA) is largely regulated by inflammation- associated cytokines and a high concentration of circulating SAA may represent an ideal marker for acute and chronic inflammatory diseases. However, SAA is also synthesized in extrahepatic tissues, e.g. human carcinoma meta... | Serum amyloid A: An acute-phase protein involved in tumour pathogenesis |
{"1014": 0.14179791510105133, "1038": 0.45994341373443604, "1040": 0.18978065252304077, "1044": 0.16110190749168396, "1052": 0.4041621685028076, "2000": 0.08871890604496002, "2001": 0.036437395960092545, "2002": 0.22782009840011597, "2022": 0.2786078155040741, "2025": 0.009718249551951885, "2034": 0.12556517124176025, ... | 31942055 | BACKGROUND Being overweight is often cited as a relative contraindication to peritoneal dialysis. Our primary objective was to determine whether actual mortality rates support this opinion. METHODS Retrospective cohort study of United States Medicare patients initiating dialysis between 1995 and 2000 (N = 418,021; 11% ... | Body size and outcomes on peritoneal dialysis in the United States. |
{"1011": 0.3070250153541565, "1013": 0.6254787445068359, "1035": 0.08961215615272522, "1039": 0.848413348197937, "1057": 0.8022117614746094, "1996": 0.3622259199619293, "2003": 0.2493593990802765, "2008": 0.27934664487838745, "2011": 0.03360854089260101, "2019": 0.4041621685028076, "2029": 0.3464667797088623, "2050": 0... | 31962403 | The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex... | The anaphase promoting complex/cyclosome: a machine designed to destroy |
{"1011": 0.33115679025650024, "1040": 0.46853771805763245, "1999": 0.03925827145576477, "2006": 0.040196798741817474, "2007": 0.2954642176628113, "2011": 0.3262358605861664, "2026": 0.5364705324172974, "2029": 0.3910386264324188, "2035": 0.07431721687316895, "2051": 0.15860503911972046, "2063": 0.24171993136405945, "20... | 32001951 | Treatment of the cultured human breast-cancer cells BC-M1 with dexamethasone induced a placental-type alkaline phosphatase (ALP). Both the ALP activity and the mRNA level in the cells were increased. The induction of ALP activity by dexamethasone was time- and dose-dependent. The accumulation of ALP mRNA was inhibited ... | Regulation of the expression of alkaline phosphatase in a human breast-cancer cell line. |
{"2001": 0.24325250089168549, "2005": 0.07431721687316895, "2025": 0.11256109178066254, "2042": 0.05417001247406006, "2043": 0.3070250153541565, "2053": 0.15693697333335876, "2061": 0.04487626627087593, "2076": 0.08154398202896118, "2087": 0.1718502640724182, "2090": 0.0913962796330452, "2091": 0.32270604372024536, "20... | 32012666 | This retrospective observational review documents the efforts of the Swaziland National Tuberculosis (TB) Control Programme between 2004 and 2014. The objective is to describe the disparity between actual declines in case notification and increases in estimated incidence. The review of policies and practices shows the ... | Declining tuberculosis notification trend associated with strengthened TB and expanded HIV care in Swaziland. |
{"1011": 0.2607102394104004, "1017": 0.5347557663917542, "1052": 0.5472630262374878, "1998": 0.1401015669107437, "2001": 0.3416208028793335, "2005": 0.2689530849456787, "2020": 0.025073638185858727, "2029": 0.11081436276435852, "2034": 0.29400965571403503, "2036": 0.02316705882549286, "2040": 0.09938567131757736, "2043... | 32023005 | In a paper arising out of an informal international consultation of specialists in the bacteriology of tuberculosis held in 1961, an attempt was made to formulate criteria, and specify technical procedures, for reliable tests of sensitivity (the absolute-concentration method, the resistance-ratio method and the proport... | Advances in techniques of testing mycobacterial drug sensitivity, and the use of sensitivity tests in tuberculosis control programmes. |
{"1011": 0.19862671196460724, "1014": 0.1212492436170578, "1048": 0.14602625370025635, "1049": 0.29400965571403503, "1052": 0.3662964701652527, "1056": 0.0029254043474793434, "2000": 0.36426326632499695, "2001": 0.12986256182193756, "2003": 0.08603433519601822, "2005": 0.08513788133859634, "2006": 0.026976587250828743,... | 32084655 | Mass-screening for lung cancer is rather a unique system in Japan. This study illustrates time from finding abnormality on mass-screening to final diagnosis of lung cancer. Among the 517 patients with lung cancer who were admitted to our hospital over a 10-year period up to December 2001, 83 (16.1%) were detected by ma... | Time from finding abnormality on mass-screening to final diagnosis of lung cancer. |
{"1011": 0.11343330889940262, "1016": 0.524982750415802, "1020": 0.06520967930555344, "1038": 1.0257055759429932, "1042": 0.22626367211341858, "1047": 1.167778730392456, "1048": 0.3850763738155365, "1056": 0.8264343738555908, "1156": 0.4537591338157654, "2005": 0.1401015669107437, "2008": 0.0354953333735466, "2011": 0.... | 32101982 | The transcription factor Krüppel-like factor 2 (KLF2) is critical for normal trafficking of T lymphocytes, but its role in B cells is unclear. We report that B cell-specific KLF2 deficiency leads to decreased expression of the trafficking molecules CD62L and β7-integrin, yet expression of sphingosine-1 phosphate recept... | Krüppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression. |
{"1014": 0.49982786178588867, "1043": 0.06429435312747955, "1053": 0.08513788133859634, "1999": 0.5871354341506958, "2001": 0.03925827145576477, "2007": 0.2105647772550583, "2012": 0.4349733293056488, "2015": 0.030771657824516296, "2018": 0.022212404757738113, "2020": 0.083342544734478, "2025": 0.20818853378295898, "20... | 32159283 | CONTEXT Increasing evidence supports the hypothesis of a causal association between certain bacterial infections and increased risk of developing acute myocardial infarction. If such a causal association exists, subjects who used antibiotics active against the bacteria, regardless of indication, might be at lower risk ... | Antibiotics and risk of subsequent first-time acute myocardial infarction. |
{"1011": 0.22704219818115234, "1038": 0.42225050926208496, "1044": 0.09584271162748337, "1051": 0.0752234235405922, "2002": 0.018384648486971855, "2007": 0.1693800985813141, "2011": 0.1221139207482338, "2029": 0.3388410806655884, "2039": 0.27786844968795776, "2076": 0.04953393340110779, "2080": 0.2822965085506439, "214... | 32170702 | Maintenance of hematopoietic stem cells (HSCs) depends on interaction with their niche. Here we show that the long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor, MPL, are a quiescent population in adult bone marrow (BM) and are closely associated with THPO-producing osteoblastic cells. THPO/MPL signaling... | Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. |
{"1014": 0.2763880789279938, "1016": 0.2160874605178833, "1039": 0.23402166366577148, "1044": 0.15610189735889435, "1052": 0.20977331697940826, "1053": 0.20501139760017395, "1054": 0.9958525896072388, "1058": 0.10467668622732162, "1609": 0.29036402702331543, "2000": 0.004870930220931768, "2001": 0.2026219218969345, "20... | 32177659 | In Catalonia, a screening protocol for cervical cancer, including human papillomavirus (HPV) DNA testing using the Digene Hybrid Capture 2 (HC2) assay, was implemented in 2006. In order to monitor interlaboratory reproducibility, a proficiency testing (PT) survey of the HPV samples was launched in 2008. The aim of this... | Interlaboratory reproducibility and proficiency testing within the human papillomavirus cervical cancer screening program in Catalonia, Spain. |
{"1997": 0.2470736801624298, "1998": 0.02792670577764511, "2015": 0.13925230503082275, "2033": 0.40806588530540466, "2037": 0.12038381397724152, "2054": 0.020300358533859253, "2057": 0.1677299439907074, "2064": 0.021256839856505394, "2075": 0.0058422754518687725, "2079": 0.23247487843036652, "2109": 0.08513788133859634... | 32181055 | We are in a phase of unprecedented progress in identifying genetic loci that cause variation in traits ranging from growth and fitness in simple organisms to disease in humans. However, a mechanistic understanding of how these loci influence traits is lacking for the majority of loci. Studies of the genetics of gene ex... | The role of regulatory variation in complex traits and disease |
{"1011": 0.19862671196460724, "1041": 0.7907629609107971, "1996": 0.2719337046146393, "1999": 0.7827593088150024, "2011": 0.42735910415649414, "2012": 0.1212492436170578, "2019": 0.1332872211933136, "2029": 0.176772341132164, "2034": 0.14686977863311768, "2047": 0.29036402702331543, "2076": 0.44691193103790283, "2078":... | 32194449 | Cytokinesis entails cell invagination by a contractile actomyosin ring. In epithelia, E-cadherin-mediated adhesion connects the cortices of contacting cells; thus, it is unclear how invagination occurs, how the new junction forms, and how tissue integrity is preserved. Investigations in Drosophila embryos first show th... | Adhesion disengagement uncouples intrinsic and extrinsic forces to drive cytokinesis in epithelial tissues. |
{"1009": 0.7701805830001831, "1011": 0.25239890813827515, "1015": 0.19381128251552582, "1021": 0.36967599391937256, "1041": 0.4770587682723999, "1047": 1.0101795196533203, "1051": 0.13414156436920166, "1060": 0.27786844968795776, "1997": 0.23092569410800934, "1999": 0.12470348179340363, "2008": 0.03925827145576477, "20... | 32250572 | Rat and human cDNAs were isolated that both encoded a 360 amino acid polypeptide with a tertiary structure typical of inwardly rectifying K+ channel (Kir) subunits. The new proteins, termed Kir7.1, were <37% identical to other Kir subunits and showed various unique residues at conserved sites, particularly near the por... | The epithelial inward rectifier channel Kir7.1 displays unusual K+ permeation properties. |
{"1014": 0.23556606471538544, "1019": 0.0842406153678894, "1040": 0.1905880719423294, "1052": 0.42353010177612305, "2003": 0.40220460295677185, "2004": 0.5551415085792542, "2005": 0.4248080551624298, "2006": 0.04674193635582924, "2047": 0.1718502640724182, "2051": 0.03360854089260101, "2080": 0.19381128251552582, "2084... | 32263707 | BACKGROUND Fingolimod (FTY720) is a new oral immunomodulating agent under evaluation for the treatment of relapsing multiple sclerosis. METHODS We randomly assigned 281 patients to receive oral fingolimod, at a dose of 1.25 mg or 5.0 mg, or a placebo once daily, and we followed these patients for 6 months with magnetic... | Oral fingolimod (FTY720) for relapsing multiple sclerosis. |
{"1046": 0.2711893916130066, "1050": 0.0913962796330452, "1052": 0.5324648022651672, "1060": 0.7647408246994019, "1165": 0.25694093108177185, "1999": 0.009718249551951885, "2007": 0.2719337046146393, "2008": 0.272677481174469, "2013": 0.0009760859538801014, "2015": 0.15359249711036682, "2024": 0.21922965347766876, "202... | 32275758 | DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and functional domain organization. We showed previously that pol mu participates in light chain but surprisingly not heavy chain gene rearrangement. We show h... | Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. |
{"1001": 0.10993985831737518, "1017": 0.23633737862110138, "1039": 0.7683706283569336, "1050": 0.0770333781838417, "1060": 0.06154331564903259, "1997": 0.029824240133166313, "1999": 0.07250232994556427, "2005": 0.026976587250828743, "2011": 0.3141832649707794, "2012": 0.30558720231056213, "2029": 0.14349138736724854, "... | 32322418 | Vascular endothelial cells produce nitric oxide (NO), which is a potent vasodilator substance and is thought to have antiatherosclerotic properties. Therefore, it has also been proposed that NO may be useful to regulate vascular tonus and prevent progression of atherosclerosis. On the other hand, NO activity reduces wi... | Moderate regular exercise increases basal production of nitric oxide in elderly women. |
{"1011": 0.14264501631259918, "1052": 0.42353010177612305, "1056": 0.12986256182193756, "2003": 0.03266380727291107, "2007": 0.11343330889940262, "2008": 0.036437395960092545, "2011": 0.36426326632499695, "2015": 0.20580662786960602, "2029": 0.2837681770324707, "2044": 0.28082266449928284, "2064": 0.16524957120418549, ... | 32324430 | Post-transcriptional gene regulation (PTGR) of mRNA turnover, localization and translation is mediated by microRNAs (miRNAs) and RNA-binding proteins (RBPs). These regulators exert their effects by binding to specific sequences within their target mRNAs. Increasing evidence suggests that competition for binding is a fu... | Competition between target sites of regulators shapes post-transcriptional gene regulation |
{"1017": 0.043007105588912964, "1021": 0.08782484382390976, "1022": 0.23556606471538544, "1057": 0.30486753582954407, "1997": 0.27786844968795776, "2001": 0.052318159490823746, "2012": 0.2089812457561493, "2034": 0.25239890813827515, "2043": 0.07793712615966797, "2045": 0.3615458607673645, "2050": 0.371698260307312, "2... | 32328114 | Stroke ranks as the third leading cause of death in the United States. It is now estimated that there are more than 700 000 incident strokes annually and 4.4 million stroke survivors.1 2 The economic burden of stroke was estimated by the American Heart Association to be $51 billion (direct and indirect costs) in 1999.3... | Primary prevention of ischemic stroke: A statement for healthcare professionals from the Stroke Council of the American Heart Association. |
{"1011": 0.4425300657749176, "1046": 0.5816917419433594, "1060": 0.00875066313892603, "1061": 1.1941591501235962, "2001": 0.010684899985790253, "2003": 0.4450363218784332, "2004": 0.07431721687316895, "2005": 0.4788752794265747, "2007": 0.38441169261932373, "2012": 0.31845372915267944, "2029": 0.04487626627087593, "204... | 32353339 | ChimeriVax-JE is a live, attenuated vaccine against Japanese encephalitis, using yellow fever (YF) 17D vaccine as a vector. In a double-blind phase 2 trial, 99 adults received vaccine, placebo, or YF 17D vaccine (YF-VAX). ChimeriVax-JE was well tolerated, with no differences in adverse events between treatment groups. ... | Chimeric live, attenuated vaccine against Japanese encephalitis (ChimeriVax-JE): phase 2 clinical trials for safety and immunogenicity, effect of vaccine dose and schedule, and memory response to challenge with inactivated Japanese encephalitis antigen. |
{"1003": 0.2026219218969345, "1014": 0.47158926725387573, "1018": 0.24401791393756866, "1022": 0.04767346754670143, "1023": 0.06703783571720123, "1043": 0.39762192964553833, "1997": 0.15777134895324707, "2043": 0.23402166366577148, "2047": 0.19782574474811554, "2085": 0.07068414986133575, "2086": 0.07159364968538284, "... | 32357890 | BACKGROUND The literature describing the global prevalence of anxiety disorders is highly variable. A systematic review and meta-regression were undertaken to estimate the prevalence of anxiety disorders and to identify factors that may influence these estimates. The findings will inform the new Global Burden of Diseas... | Global prevalence of anxiety disorders: a systematic review and meta-regression. |
{"1016": 0.09850110858678818, "1041": 0.0058422754518687725, "1043": 0.5347557663917542, "1051": 0.5690577030181885, "1999": 0.09850110858678818, "2005": 0.1212492436170578, "2011": 0.15359249711036682, "2029": 0.22937409579753876, "2039": 0.056018441915512085, "2048": 0.06429435312747955, "2050": 0.07793712615966797, ... | 32372280 | Optineurin (optic neuropathy inducing protein; OPTN) was recently linked to 16.7% of families with primary open-angle glaucoma. The function of OPTN in the eye is not known, but is present in the trabecular meshwork, which is responsible for maintenance of intraocular pressure (IOP). To gain insight into the role of OP... | Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure. |
{"1020": 0.22001366317272186, "1051": 0.12038381397724152, "1052": 0.20421554148197174, "2000": 0.15777134895324707, "2003": 0.12986256182193756, "2005": 0.21135559678077698, "2011": 0.18816383183002472, "2020": 0.06337817758321762, "2044": 0.16524957120418549, "2045": 0.08064348995685577, "2076": 0.4337083101272583, "... | 32390525 | CONTEXT Long-term travelers, defined here as those traveling for periods of 6 months or longer, face particular challenges regarding malaria prevention. Current guidelines for malaria prevention primarily address prevention of Plasmodium falciparum infections in short-term travelers. OBJECTIVES To examine the risk of m... | Prevention of malaria in long-term travelers. |
{"1015": 0.06795065850019455, "1038": 0.06612417846918106, "1155": 0.37371641397476196, "1999": 0.10993985831737518, "2004": 0.06886265426874161, "2029": 0.1485546976327896, "2039": 0.022212404757738113, "2058": 0.08603433519601822, "2079": 0.22782009840011597, "2091": 0.05139094591140747, "2107": 0.06612417846918106, ... | 32408470 | Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia. However, the mechanisms behind these effects are unclear. Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase α2 ... | Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo |
{"1011": 0.2105647772550583, "1014": 0.06977381557226181, "1017": 0.06703783571720123, "1022": 0.11081436276435852, "1041": 0.304147332906723, "1053": 0.5427330136299133, "1997": 0.4132472574710846, "2001": 0.2674594223499298, "2005": 0.0913962796330452, "2006": 0.371698260307312, "2020": 0.19220098853111267, "2022": 0... | 32421068 | Objective To determine the availability of data on overall survival and quality of life benefits of cancer drugs approved in Europe. Design Retrospective cohort study. Setting Publicly accessible regulatory and scientific reports on cancer approvals by the European Medicines Agency (EMA) from 2009 to 2013.Main outcome ... | Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13 |
{"1004": 0.02887592278420925, "1023": 0.09050461649894714, "1039": 0.14686977863311768, "1043": 0.4311734735965729, "1050": 0.41840189695358276, "1998": 0.5174443125724792, "2001": 0.22001366317272186, "2012": 0.176772341132164, "2014": 0.06337817758321762, "2040": 0.00875066313892603, "2043": 0.347847044467926, "2057"... | 32423829 | Cervix and Breast cancers are the most common cancers among women worldwide and extract a large toll in developing countries. In May 1998, supported by a grant from the NCI (US), the Tata Memorial Hospital, Mumbai, India, started a cluster-randomized, controlled, screening-trial for cervix and breast cancer using train... | A cluster randomized, controlled trial of breast and cervix cancer screening in Mumbai, India: methodology and interim results after three rounds of screening. |
{"1017": 0.05417001247406006, "1018": 0.3353555500507355, "1020": 0.2409527748823166, "1040": 0.08871890604496002, "1050": 0.5540198087692261, "1051": 0.3318578004837036, "1052": 0.33953672647476196, "1053": 0.10818854719400406, "1997": 0.030771657824516296, "1999": 0.15526613593101501, "2003": 0.21922965347766876, "20... | 32450297 | THE herbicide paraquat (N,N′-dimethyl 4,4′-bipyridilium) can produce widespread oedema and fibrosis in the human lung after accidental ingestion1–3. In those cases where death occurs after several weeks, there are no apparent pulmonary changes during the first few days following ingestion. Animal experiments in a varie... | Evidence for energy-dependent accumulation of paraquat into rat lung |
{"1009": 0.4487839937210083, "1020": 0.22548456490039825, "1039": 0.35745587944984436, "1041": 0.2667117714881897, "1048": 0.3897167444229126, "1055": 0.5295937061309814, "1056": 0.7333439588546753, "1999": 0.17267228662967682, "2005": 0.2976420819759369, "2038": 0.022212404757738113, "2042": 0.04487626627087593, "2063... | 32454714 | Mucosal tolerance has been considered a potentially important pathway for the treatment of autoimmune disease, including human multiple sclerosis and experimental conditions such as experimental autoimmune encephalomyelitis (EAE). There is limited information on the capacity of commensal gut bacteria to induce and main... | Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis. |
{"1008": 0.08513788133859634, "1047": 0.40351006388664246, "1048": 0.09317722171545029, "2001": 0.14095009863376617, "2018": 0.11256109178066254, "2020": 0.08692999184131622, "2041": 0.10731173306703568, "2043": 0.0606246218085289, "2051": 0.12986256182193756, "2058": 0.2689530849456787, "2077": 0.06795065850019455, "2... | 32462603 | OBJECTIVE To determine the incidence of surgically managed pelvic organ prolapse and urinary incontinence in a population-based cohort, and to describe their clinical characteristics. METHODS Our retrospective cohort study included all patients undergoing surgical treatment for prolapse and incontinence during 1995; al... | Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. |
{"1014": 0.4002431631088257, "1016": 0.25995752215385437, "1050": 0.2184450328350067, "1052": 0.45251765847206116, "1081": 0.5795059204101562, "1156": 0.7258110046386719, "2007": 0.20660123229026794, "2020": 0.013579257763922215, "2035": 0.2223619967699051, "2038": 0.053244512528181076, "2062": 0.27934664487838745, "20... | 32463364 | OBJECTIVES Prevention of cognitive decline and dementia with blood pressure lowering treatments has shown inconsistent results. We compared the effects of different classes of antihypertensive drugs on the incidence of dementia, and on cognitive function. METHODS We conducted a systematic review and included 19 randomi... | Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis. |
{"1011": 0.14264501631259918, "1014": 0.5341835021972656, "1020": 0.6719275116920471, "1022": 0.31132611632347107, "1023": 0.30558720231056213, "1038": 0.17759032547473907, "1039": 0.4228905141353607, "1040": 0.23633737862110138, "1043": 0.5800528526306152, "1044": 0.8731874823570251, "1055": 0.4824984669685364, "1997"... | 32481310 | Hemolysates of erythrocytes from more than a quarter million people in Alabama were electrophoresed on cellulose acetate, pH 8.4, and those samples exhibiting an abnormality were also electrophoresed in citrate agar, pH 6.0. The globin chains of mutants other than Hb S and C were electrophoresed in urea-mercaptoethanol... | Abnormal hemoglobins in a quarter million people. |
{"1011": 0.129004567861557, "1018": 0.4679262638092041, "1039": 0.7144040465354919, "1054": 0.5370414853096008, "2000": 0.20022670924663544, "2001": 0.007782140281051397, "2011": 0.2317005842924118, "2012": 0.42353010177612305, "2020": 0.0913962796330452, "2029": 0.1064341589808464, "2033": 0.6435998678207397, "2034": ... | 32532238 | To understand how cells sense and adapt to mechanical stress, we applied tensional forces to magnetic microbeads bound to cell-surface integrin receptors and measured changes in bead displacement with sub-micrometer resolution using optical microscopy. Cells exhibited four types of mechanical responses: (1) an immediat... | Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. |
{"1011": 0.42990362644195557, "1017": 0.25995752215385437, "1039": 0.6128603219985962, "1045": 0.07341018319129944, "1048": 0.13414156436920166, "1999": 0.5238267183303833, "2005": 0.1358480453491211, "2007": 0.08513788133859634, "2008": 0.022212404757738113, "2011": 0.36967599391937256, "2029": 0.2763880789279938, "20... | 32533299 | The proinflammatory cytokine IL-1beta plays an important role in antifungal immunity; however, the mechanisms by which fungal pathogens trigger IL-1beta secretion are unclear. In this study we show that infection with Candida albicans is sensed by the Nlrp3 inflammasome, resulting in the subsequent release of IL-1beta.... | Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. |
{"1014": 0.0009760859538801014, "1016": 0.8459017872810364, "1044": 0.39433568716049194, "1998": 0.0174254160374403, "2007": 0.26146242022514343, "2031": 0.11168810725212097, "2038": 0.09850110858678818, "2048": 0.5151132941246033, "2058": 0.03360854089260101, "2089": 0.2674594223499298, "2090": 0.417115718126297, "209... | 32534305 | OBJECTIVE Hyperinsulinemia may promote mammary carcinogenesis. Insulin resistance has been linked to an increased risk of breast cancer and is also characteristic of type 2 diabetes. We prospectively evaluated the association between type 2 diabetes and invasive breast cancer incidence in the Nurses' Health Study. RESE... | Type 2 diabetes and subsequent incidence of breast cancer in the Nurses' Health Study. |
{"1011": 0.04113444685935974, "1037": 0.0174254160374403, "2003": 0.18004031479358673, "2005": 0.015504186972975731, "2008": 0.12642613053321838, "2015": 0.401551216840744, "2024": 0.3995884954929352, "2050": 0.15526613593101501, "2054": 0.04113444685935974, "2078": 0.6461620330810547, "2079": 0.306306391954422, "2089"... | 32556431 | MicroRNAs (miRNAs) are the subject of enormous interest. They are small non-coding RNAs that play a regulatory role in numerous and diverse cellular processes such as immune function, apoptosis and tumorigenesis. Several virus families have been shown to encode miRNAs, and an appreciation for their roles in the viral i... | Virus-encoded microRNAs. |
{"1011": 0.23247487843036652, "1015": 0.32553088665008545, "1016": 0.7969439625740051, "1022": 0.08871890604496002, "1043": 0.5393219590187073, "1059": 0.9139442443847656, "1156": 1.004473328590393, "1996": 0.2531573474407196, "2005": 0.030771657824516296, "2006": 0.08603433519601822, "2029": 0.11865071207284927, "2048... | 32587939 | Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its role in β-cell function remains unclear. Here we provide e... | Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion |
{"1011": 0.11691460013389587, "1015": 0.176772341132164, "1040": 0.3676496744155884, "1043": 0.8550800085067749, "1050": 0.45251765847206116, "1155": 0.13499516248703003, "2008": 0.14518201351165771, "2011": 0.5438674688339233, "2013": 0.4855078160762787, "2020": 0.0029254043474793434, "2028": 0.0606246218085289, "2029... | 32598644 | In this study, we present data showing that two members of the GRAS family of genes from rice, CIGR1 and CIGR2(chitin-inducible gibberellin-responsive), inducible by the potent elicitor N-acetylchitooligosaccharide (GN), are rapidly induced by exogenous gibberellins. The pattern of mRNA accumulation was dependent on th... | Two Rice GRAS Family Genes Responsive to N-Acetylchitooligosaccharide Elicitor are Induced by Phytoactive Gibberellins: Evidence for Cross-Talk Between Elicitor and Gibberellin Signaling in Rice Cells |
{"1011": 0.11778303235769272, "1016": 0.255429208278656, "1043": 1.034073829650879, "1054": 0.6064908504486084, "2001": 0.08244366943836212, "2003": 0.3588210940361023, "2005": 0.09050461649894714, "2011": 0.3588210940361023, "2013": 0.23556606471538544, "2024": 0.0354953333735466, "2029": 0.12384103983640671, "2034": ... | 32611468 | Ghrelin, a 28 amino acid peptide hormone produced by the stomach, was the first orexigenic hormone to be discovered from the periphery. The octanoyl modification at Ser³, mediated by ghrelin O-acyltransferase (GOAT), is essential for ghrelin's biological activity. Ghrelin stimulates food intake through binding to its r... | Ghrelin's second life: from appetite stimulator to glucose regulator. |
{"1040": 0.10026945173740387, "1044": 0.4067663550376892, "1048": 0.5433003902435303, "1998": 0.19381128251552582, "1999": 0.12728634476661682, "2002": 0.41065993905067444, "2004": 0.10203468054533005, "2005": 0.17840765416622162, "2008": 0.10379679501056671, "2010": 1.2244645357131958, "2011": 0.32058215141296387, "20... | 32638085 | Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an untargeted and global manner, by affecting most nucleosomes. Recently, new roles for histone acetylation have been uncovered, not only in transcription bu... | Histone acetylation and deacetylation in yeast |
{"1039": 0.10467668622732162, "1043": 0.5756692886352539, "1998": 0.1710275560617447, "2013": 0.06429435312747955, "2044": 0.6420594453811646, "2045": 0.22626367211341858, "2051": 0.6054253578186035, "2067": 0.6275664567947388, "2076": 0.02887592278420925, "2079": 0.1602703034877777, "2083": 0.04113444685935974, "2089"... | 32665136 | Traumatic spinal cord injury triggers a complex local inflammatory reaction capable of enhancing repair and exacerbating pathology. The composition and effector potential of the post-injury cellular and molecular immune cascade changes as a function of time and distance from the lesion. Production along this time-space... | Neuroinflammation in spinal cord injury: therapeutic targets for neuroprotection and regeneration. |
{"1011": 0.1064341589808464, "1052": 0.9379299283027649, "1999": 0.036437395960092545, "2001": 0.07793712615966797, "2003": 0.23324857652187347, "2005": 0.1718502640724182, "2006": 0.4248080551624298, "2007": 0.07250232994556427, "2008": 0.045809537172317505, "2011": 0.05417001247406006, "2029": 0.009718249551951885, "... | 32671519 | BACKGROUND In systemic amyloidosis the distribution and progression of disease have been difficult to monitor, because they can be demonstrated only by biopsy. Serum amyloid P component (SAP) is a normal circulating plasma protein that is deposited on amyloid fibrils because of its specific binding affinity for them. W... | Evaluation of systemic amyloidosis by scintigraphy with 123I-labeled serum amyloid P component. |
{"1050": 1.3038887977600098, "1058": 0.037378571927547455, "1996": 0.35060185194015503, "2001": 0.20501139760017395, "2003": 0.13499516248703003, "2043": 0.1602703034877777, "2049": 0.29400965571403503, "2053": 0.39893341064453125, "2078": 0.03360854089260101, "2079": 0.04674193635582924, "2090": 0.3141832649707794, "2... | 32697244 | The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress Review Group meeting of the National Institute of Neurological Disorders and Stroke, emphasizes the intimate relationship between the brain and its vessels. Since then, the NVU has attracted the interest of the neuroscience community, r... | The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease |
{"1003": 0.03925827145576477, "1020": 0.3777405619621277, "1043": 0.4444103240966797, "1055": 0.07159364968538284, "1997": 0.10026945173740387, "1998": 0.15943801403045654, "1999": 0.4132472574710846, "2003": 0.004870930220931768, "2005": 0.1970241367816925, "2011": 0.4267219603061676, "2029": 0.3084607720375061, "2048... | 32712381 | The predominant fermentable sugar in lean dough is maltose. To improve the leavening ability of baker's yeast in lean dough, maltose metabolism should be improved. Maltase (alpha-glucosidase, encoded by MAL62) and maltose permease (encoded by MAL61) are the major factors involved in maltose metabolism. The major rate-l... | Effects of MAL61 and MAL62 overexpression on maltose fermentation of baker's yeast in lean dough. |
{"1052": 0.1710275560617447, "1999": 0.12384103983640671, "2008": 0.030771657824516296, "2014": 0.8567397594451904, "2015": 0.39433568716049194, "2025": 0.3339579105377197, "2029": 0.255429208278656, "2031": 0.0752234235405922, "2036": 0.04394211992621422, "2042": 0.2539152204990387, "2043": 0.022212404757738113, "2073... | 32720933 | It has recently become clear that several pathogenic DNA viruses express virally encoded microRNAs in infected cells. In particular, numerous microRNAs have been identified in a range of human and animal herpesviruses, and individual microRNAs have also been identified in members of the polyoma- and adenovirus families... | Human papillomavirus genotype 31 does not express detectable microRNA levels during latent or productive virus replication. |
{"1003": 0.06337817758321762, "1011": 0.0009760859538801014, "1017": 0.5313173532485962, "1047": 0.16359257698059082, "1052": 0.39893341064453125, "1999": 0.037378571927547455, "2006": 0.255429208278656, "2007": 0.16607704758644104, "2010": 0.6714286804199219, "2011": 0.037378571927547455, "2012": 0.10467668622732162, ... | 32721137 | Although 75% of endometrial cancers are treated at an early stage, 15% to 20% of these recur. We performed an integrated analysis of genome-wide expression and copy-number data for primary endometrial carcinomas with extensive clinical and histopathological data to detect features predictive of recurrent disease. Unsup... | Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. |
{"1011": 0.0174254160374403, "1042": 0.15442965924739838, "2003": 0.0913962796330452, "2008": 0.01934296265244484, "2015": 0.9546096324920654, "2024": 0.1064341589808464, "2029": 0.09406650811433792, "2050": 0.10906458646059036, "2075": 0.05970508232712746, "2076": 0.1693800985813141, "2079": 0.30917787551879883, "2087... | 32742683 | Among cells present in the tumor microenvironment, activated fibroblasts termed cancer-associated fibroblasts (CAFs), play a critical role in the complex process of tumor-stroma interaction. CAFs, one of the prominent stromal cell populations in most types of human carcinomas, have been involved in tumor growth, angiog... | Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts |
{"1011": 0.045809537172317505, "1040": 0.4132472574710846, "1999": 0.7009293437004089, "2007": 0.10906458646059036, "2044": 0.7314660549163818, "2046": 0.32199856638908386, "2057": 0.4349733293056488, "2070": 0.06886265426874161, "2076": 0.06520967930555344, "2093": 0.06703783571720123, "2094": 0.015504186972975731, "2... | 32743723 | We examined six patients with an abrupt change in behavior after infarction involving the inferior genu of the internal capsule. The acute syndrome featured fluctuating alertness, inattention, memory loss, apathy, abulia, and psychomotor retardation, suggesting frontal lobe dysfunction. Contralateral hemiparesis and dy... | Confusion and memory loss from capsular genu infarction: a thalamocortical disconnection syndrome? |
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