spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1011": 0.26146242022514343, "1039": 0.7898768186569214, "1048": 0.06520967930555344, "1056": 1.1947507858276367, "2010": 0.12642613053321838, "2015": 0.02316705882549286, "2026": 1.2791962623596191, "2029": 0.20660123229026794, "2033": 0.2689530849456787, "2043": 0.1930064558982849, "2070": 0.17267228662967682, "2076... | 34436231 | Immature T cells and some T cell hybridomas undergo apoptotic cell death when activated through the T cell receptor complex, a phenomenon that is probably related to antigen induced negative selection of developing T cells. This activation-induced apoptosis depends on active protein and RNA synthesis in the dying cells... | Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. |
{"1011": 0.5220900774002075, "1015": 0.1229778528213501, "1016": 0.817850649356842, "1017": 0.31132611632347107, "1020": 0.14095009863376617, "1023": 0.07159364968538284, "1038": 1.0066169500350952, "1039": 0.043007105588912964, "1041": 0.29255300760269165, "1048": 0.2881702482700348, "1052": 0.1913948506116867, "1060"... | 34439544 | The BCL-2 (B cell CLL/Lymphoma) family is comprised of approximately twenty proteins that collaborate to either maintain cell survival or initiate apoptosis(1). Following cellular stress (e.g., DNA damage), the pro-apoptotic BCL-2 family effectors BAK (BCL-2 antagonistic killer 1) and/or BAX (BCL-2 associated X protein... | Examining BCL-2 family function with large unilamellar vesicles. |
{"1056": 0.32905077934265137, "1061": 0.17759032547473907, "2002": 0.8796916007995605, "2003": 0.0797421783208847, "2011": 0.3269403576850891, "2015": 0.12470348179340363, "2049": 0.020300358533859253, "2064": 0.12986256182193756, "2076": 0.4437839686870575, "2079": 0.08154398202896118, "2091": 0.13071982562541962, "21... | 34445160 | BACKGROUND & AIMS Hepatic stellate cell activation is a wound-healing response to liver injury. However, continued activation of stellate cells during chronic liver damage causes excessive matrix deposition and the formation of pathological scar tissue leading to fibrosis and ultimately cirrhosis. The importance of sus... | The Hippo pathway effector YAP controls mouse hepatic stellate cell activation. |
{"1011": 0.4248080551624298, "1015": 0.8957691192626953, "1017": 0.030771657824516296, "1045": 0.17840765416622162, "1047": 0.3877306580543518, "1048": 0.11430477350950241, "1052": 0.09938567131757736, "1056": 0.8780695199966431, "1999": 0.6892333030700684, "2003": 0.14433705806732178, "2004": 0.16607704758644104, "200... | 34469966 | Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a species-specific response that is not observed in the... | Human Monocytes Engage an Alternative Inflammasome Pathway. |
{"1038": 0.40611594915390015, "1054": 0.9209672808647156, "2003": 0.35334911942481995, "2005": 0.5957841277122498, "2019": 0.3134697377681732, "2024": 0.4512746334075928, "2029": 0.0029254043474793434, "2050": 0.2105647772550583, "2054": 0.08154398202896118, "2069": 0.010684899985790253, "2072": 0.2983669638633728, "20... | 34481589 | Biological agents are widely used in rheumatology, dermatology and inflammatory bowel disease. Evidence about their efficacy and safety has been strengthened for all those therapeutic indications over the last decade. Biosimilar agents are monoclonal antibodies similar to previously approved biologics. In the European ... | The use of biosimilars in immune-mediated disease: A joint Italian Society of Rheumatology (SIR), Italian Society of Dermatology (SIDeMaST), and Italian Group of Inflammatory Bowel Disease (IG-IBD) position paper. |
{"1040": 0.9131608605384827, "1047": 0.5506471395492554, "1061": 0.11081436276435852, "1996": 0.41840189695358276, "1997": 0.14264501631259918, "1999": 0.1221139207482338, "2000": 0.07793712615966797, "2003": 0.05970508232712746, "2007": 0.30486753582954407, "2011": 0.175953671336174, "2012": 0.28082266449928284, "2029... | 34498093 | The dynein motor domain is composed of a tail, head, and stalk and is thought to generate a force to microtubules by swinging the tail against the head during its ATPase cycle. For this "power stroke," dynein has to coordinate the tail swing with microtubule association/dissociation at the tip of the stalk. Although a ... | The coordination of cyclic microtubule association/dissociation and tail swing of cytoplasmic dynein. |
{"1006": 0.03360854089260101, "1011": 0.22392450273036957, "1016": 0.1946154683828354, "1017": 0.05694137513637543, "1019": 0.3676496744155884, "1043": 0.8004589080810547, "1048": 0.7105726003646851, "1055": 0.2837681770324707, "1056": 0.3416208028793335, "1057": 0.7220231294631958, "1060": 0.8289952278137207, "1996": ... | 34498325 | Transfer RNAs specific for Gln, Lys, and Glu from all organisms (except Mycoplasma) and organelles have a 2-thiouridine derivative (xm(5)s(2)U) as wobble nucleoside. These tRNAs read the A- and G-ending codons in the split codon boxes His/Gln, Asn/Lys, and Asp/Glu. In eukaryotic cytoplasmic tRNAs the conserved constitu... | A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast. |
{"1054": 0.45623743534088135, "1996": 0.23247487843036652, "1997": 0.09317722171545029, "1999": 0.24248650670051575, "2006": 0.04394211992621422, "2008": 0.23479416966438293, "2011": 0.3134697377681732, "2026": 0.009718249551951885, "2029": 0.255429208278656, "2043": 0.176772341132164, "2044": 0.27712854743003845, "204... | 34537906 | After anaphase onset, animal cells build an actomyosin contractile ring that constricts the plasma membrane to generate two daughter cells connected by a cytoplasmic bridge. The bridge is ultimately severed to complete cytokinesis. Myriad techniques have been used to identify proteins that participate in cytokinesis in... | The molecular requirements for cytokinesis. |
{"1014": 0.16276304423809052, "1050": 0.450652539730072, "1052": 0.13157635927200317, "2003": 0.04953393340110779, "2004": 0.24248650670051575, "2005": 0.3012613356113434, "2029": 0.021256839856505394, "2050": 0.567397952079773, "2060": 0.14349138736724854, "2078": 0.12642613053321838, "2080": 0.32270604372024536, "208... | 34544514 | BACKGROUND Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be as effective as indomethacin with fewer adverse effects. OBJECTIVES To determine the effectiveness and safety of... | Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. |
{"1011": 0.2089812457561493, "1017": 0.4462870955467224, "1040": 0.25088030099868774, "1046": 0.29109421372413635, "1050": 0.0174254160374403, "1052": 0.38905516266822815, "1056": 0.055094651877880096, "1058": 0.04113444685935974, "1060": 1.0144377946853638, "1165": 0.20501139760017395, "1997": 0.11778303235769272, "19... | 34559336 | Three Pol X family members have been linked to nonhomologous end joining (NHEJ) in mammals. Template-independent TdT promotes diversity during NHEJ-dependent repair of V(D)J recombination intermediates, but the roles of the template-dependent polymerases mu and lambda in NHEJ remain unclear. We show here that pol mu an... | A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. |
{"1003": 0.03360854089260101, "1018": 0.09406650811433792, "1041": 0.026025565341114998, "1058": 0.03831886500120163, "1059": 0.23864774405956268, "1996": 0.4624064862728119, "1999": 0.058784693479537964, "2007": 0.012615402229130268, "2011": 0.2089812457561493, "2025": 0.09672962874174118, "2029": 0.11517547070980072,... | 34582256 | The object of this study was to assess the role of brown adipose tissue (BAT) and the sympathetic nervous system in the rise in heat production associated with endotoxin-induced fever. Oxygen consumption (VO2) was found to be significantly increased (28%) over a 4-h period after two doses of endotoxin (Escherichia coli... | Involvement of sympathetic nervous system and brown fat in endotoxin-induced fever in rats. |
{"1011": 0.009718249551951885, "2002": 0.450652539730072, "2003": 0.2447827309370041, "2005": 0.2034190446138382, "2011": 0.040196798741817474, "2029": 0.0058422754518687725, "2054": 0.18978065252304077, "2079": 0.129004567861557, "2104": 0.3318578004837036, "2109": 0.022212404757738113, "2140": 0.12384103983640671, "2... | 34603465 | Choline is an essential nutrient and methyl donor required for epigenetic regulation. Here, we assessed the impact of gut microbial choline metabolism on bacterial fitness and host biology by engineering a microbial community that lacks a single choline-utilizing enzyme. Our results indicate that choline-utilizing bact... | Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption. |
{"1011": 0.1718502640724182, "1054": 0.4487839937210083, "1055": 0.4158279001712799, "2003": 0.0606246218085289, "2004": 0.7067264318466187, "2007": 0.016465263441205025, "2008": 0.11517547070980072, "2011": 0.3982778787612915, "2024": 0.23479416966438293, "2029": 0.16524957120418549, "2033": 0.5640701055526733, "2048"... | 34604584 | SR proteins are well-characterized RNA binding proteins that promote exon inclusion by binding to exonic splicing enhancers (ESEs). However, it has been unclear whether regulatory rules deduced on model genes apply generally to activities of SR proteins in the cell. Here, we report global analyses of two prototypical S... | Genome-wide analysis reveals SR protein cooperation and competition in regulated splicing. |
{"1011": 0.07159364968538284, "1022": 0.06520967930555344, "1038": 0.306306391954422, "1042": 0.6430866718292236, "1048": 0.46608972549438477, "1996": 0.3019835948944092, "1997": 0.0354953333735466, "1999": 0.14602625370025635, "2003": 0.09672962874174118, "2004": 0.016465263441205025, "2005": 0.09850110858678818, "201... | 34615397 | The human tuberculous granuloma provides the morphological basis for local immune processes central to the outcome of tuberculosis. Because of the scarcity of information in human patients, the aim of the present study was to gain insights into the functional and structural properties of infiltrated tissue. To this end... | Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung. |
{"1011": 0.14518201351165771, "1041": 1.0587663650512695, "1045": 0.49626702070236206, "1999": 0.21687394380569458, "2005": 0.052318159490823746, "2011": 0.4412745535373688, "2013": 0.15359249711036682, "2024": 0.26296505331993103, "2026": 0.1970241367816925, "2029": 0.17431432008743286, "2037": 0.08064348995685577, "2... | 34630025 | Eosinophils are abundant in inflammatory demyelinating lesions in neuromyelitis optica (NMO). We used cell culture, ex vivo spinal cord slices, and in vivo mouse models of NMO to investigate the role of eosinophils in NMO pathogenesis and the therapeutic potential of eosinophil inhibitors. Eosinophils cultured from mou... | Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica. |
{"1014": 0.436867892742157, "1026": 0.3070250153541565, "1042": 0.2034190446138382, "1052": 0.6348392367362976, "1999": 0.1710275560617447, "2002": 0.0174254160374403, "2004": 0.026025565341114998, "2007": 0.37304413318634033, "2013": 0.1685553640127182, "2029": 0.14264501631259918, "2031": 0.05417001247406006, "2038":... | 34733465 | BACKGROUND Patients with cystic fibrosis have altered levels of plasma fatty acids. We previously demonstrated that arachidonic acid levels are increased and docosahexaenoic acid levels are decreased in affected tissues from cystic fibrosis-knockout mice. In this study we determined whether humans with mutations in the... | Association of cystic fibrosis with abnormalities in fatty acid metabolism. |
{"1011": 0.014542185701429844, "1996": 0.19622190296649933, "2007": 0.3526630103588104, "2011": 0.07793712615966797, "2012": 0.2493593990802765, "2015": 0.14602625370025635, "2029": 0.18004031479358673, "2037": 0.025073638185858727, "2046": 0.36426326632499695, "2050": 0.5074998140335083, "2073": 0.11168810725212097, "... | 34735369 | Recent advances in the field of intercellular adhesion highlight the importance of adherens junction association with the underlying actin cytoskeleton. In skin epithelial cells a dynamic feature of adherens junction formation involves filopodia, which physically project into the membrane of adjacent cells, catalyzing ... | Actin dynamics and cell-cell adhesion in epithelia. |
{"1011": 0.11604541540145874, "1037": 0.7537717819213867, "1044": 0.8433839678764343, "2002": 0.15693697333335876, "2010": 0.6139179468154907, "2015": 0.8748174905776978, "2050": 0.15023678541183472, "2151": 0.09495500475168228, "2168": 0.2478361576795578, "2214": 0.31489628553390503, "2220": 0.2501201331615448, "2287"... | 34747208 | Mutations in the nuclear structural protein lamin A cause the premature aging syndrome Hutchinson-Gilford progeria (HGPS). Whether lamin A plays any role in normal aging is unknown. We show that the same molecular mechanism responsible for HGPS is active in healthy cells. Cell nuclei from old individuals acquire defect... | Lamin A-dependent nuclear defects in human aging. |
{"1011": 0.31204116344451904, "1062": 1.2123361825942993, "1996": 0.018384648486971855, "2003": 0.3560888469219208, "2013": 0.13755162060260773, "2029": 0.12556517124176025, "2063": 0.2493593990802765, "2102": 0.06703783571720123, "2128": 0.09672962874174118, "2179": 0.2689530849456787, "2193": 0.09228714555501938, "22... | 34753204 | Zmpste24 is an integral membrane metalloproteinase of the endoplasmic reticulum. Biochemical studies of tissues from Zmpste24-deficient mice (Zmpste24(-/-)) have indicated a role for Zmpste24 in the processing of CAAX-type prenylated proteins. Here, we report the pathologic consequences of Zmpste24 deficiency in mice. ... | Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. |
{"1014": 0.36290550231933594, "1017": 0.04207121208310127, "1023": 0.6714286804199219, "1049": 0.6096806526184082, "1051": 0.6286086440086365, "1999": 0.24401791393756866, "2006": 0.05139094591140747, "2008": 0.020300358533859253, "2013": 0.5685047507286072, "2020": 0.12728634476661682, "2027": 0.06612417846918106, "20... | 34760396 | The fly Musca sorbens Wiedemann (Diptera: Muscidae) apparently transmits Chlamydia trachomatis, causing human trachoma. The literature indicates that M. sorbens breeds predominantly in isolated human faeces on the soil surface, but not in covered pit latrines. We sought to identify breeding media of M. sorbens in a rur... | Human and other faeces as breeding media of the trachoma vector Musca sorbens. |
{"1049": 0.5330380201339722, "1996": 0.45932671427726746, "2001": 0.07068414986133575, "2004": 0.03360854089260101, "2005": 0.14095009863376617, "2013": 0.20739519596099854, "2015": 0.11778303235769272, "2020": 0.45870962738990784, "2027": 0.46853771805763245, "2031": 0.18004031479358673, "2037": 0.32129061222076416, "... | 34818263 | As time passes, the AIDS pandemic continues to spike, affecting an estimated 38.6 million people worldwide. In response, a satellite health clinic is being d esigned by two Cal Poly students to serve the Maasai people living in the Kajiado district in Southern Kenya. The Maasai have traditionally lived as pastoralists,... | Current Health and Environmental Status of the Maasai People in Sub-Saharan Africa |
{"1009": 0.2954642176628113, "1011": 0.06795065850019455, "1020": 0.19381128251552582, "1022": 0.11691460013389587, "1023": 1.0907690525054932, "1043": 0.272677481174469, "1048": 0.04767346754670143, "1999": 0.0317181795835495, "2011": 0.29328158497810364, "2012": 0.255429208278656, "2013": 0.09495500475168228, "2029":... | 34846352 | A novel mammalian adenylyl cyclase was identified by reverse transcription-polymerase chain reaction amplification using degenerate primers based on a conserved region of previously described adenylyl cyclases (Premont, R. T. (1994) Methods Enzymol. 238, 116-127). The full-length cDNA sequence obtained from mouse brain... | Identification and characterization of a widely expressed form of adenylyl cyclase. |
{"1011": 0.3676496744155884, "1017": 0.15777134895324707, "1048": 0.07884006202220917, "1056": 0.28597161173820496, "1996": 0.2317005842924118, "1997": 0.417115718126297, "2007": 0.14686977863311768, "2008": 0.15442965924739838, "2011": 0.23402166366577148, "2026": 0.8941729068756104, "2029": 0.3903779089450836, "2033"... | 34854444 | The gene-of-the-oligodendrocyte lineage (Golli)-MBP transcription unit contains three Golli-specific exons together with eight exons of the "classical" myelin basic protein (MBP) gene, yielding alternatively spliced proteins which share amino acid sequence with MBP. Unlike MBP, a late antigen expressed only in the nerv... | Expression of Golli mRNA during development in primary immune lymphoid organs of the rat |
{"1011": 0.0029254043474793434, "1013": 0.347847044467926, "1014": 0.6038249135017395, "1019": 0.1384023278951645, "1021": 0.034552380442619324, "1026": 0.07612881064414978, "1041": 0.20022670924663544, "1048": 0.45870962738990784, "1053": 0.11343330889940262, "1056": 0.848413348197937, "1999": 0.5573811531066895, "200... | 34873974 | OBJECTIVE To obtain summary estimates of the accuracy of a single baseline measurement of the Elecsys Troponin T high-sensitive assay (Roche Diagnostics) for the diagnosis of acute myocardial infarction in patients presenting to the emergency department. DESIGN Systematic review and meta-analysis of diagnostic test acc... | Diagnostic accuracy of single baseline measurement of Elecsys Troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis |
{"1011": 0.020300358533859253, "1052": 0.1602703034877777, "1060": 0.4450363218784332, "1996": 0.06154331564903259, "1999": 0.1677299439907074, "2003": 0.04394211992621422, "2004": 0.01934296265244484, "2011": 0.09850110858678818, "2013": 0.2394166737794876, "2015": 0.3949938118457794, "2024": 0.3034266233444214, "2033... | 34876410 | Pericytes are defined in vivo by their location: They are embedded within the basement membrane of microvessels. They form an integral part of the microvascular wall and are believed to participate in angiogenesis, although their precise role is not clear. Pericytes derived from the retinal microvasculature have been c... | Pericyte differentiation. |
{"1011": 0.4286321699619293, "1013": 0.029824240133166313, "1017": 0.47463157773017883, "1039": 0.21530038118362427, "1040": 0.5618454217910767, "1056": 1.0312920808792114, "1996": 0.39762192964553833, "1998": 0.14518201351165771, "2005": 0.22859740257263184, "2007": 0.4002431631088257, "2008": 0.06703783571720123, "20... | 34905328 | The TCR:CD3 complex transduces signals that are critical for optimal T cell development and adaptive immunity. In resting T cells, the CD3ε cytoplasmic tail associates with the plasma membrane via a proximal basic-rich stretch (BRS). In this study, we show that mice lacking a functional CD3ε-BRS exhibited substantial r... | Membrane association of the CD3ε signaling domain is required for optimal T cell development and function. |
{"1039": 0.0019512200960889459, "1042": 0.8039615154266357, "1051": 0.5347557663917542, "1055": 0.24018502235412598, "1062": 0.0019512200960889459, "2004": 0.5381823778152466, "2005": 0.4879087805747986, "2007": 0.4349733293056488, "2029": 0.15275461971759796, "2064": 0.3381449282169342, "2066": 0.056018441915512085, "... | 34935825 | OBJECTIVE To evaluate the efficacy of aromatase inhibitors in ovulation induction, superovulation, and IVF. DESIGN A literature search was conducted with the key words "aromatase inhibitor," "letrozole," "anastrazole," "ovulation induction," "ovulation," and "superovulation" in MEDLINE, EMBASE, and the Cochrane Databas... | A new era in ovulation induction. |
{"1044": 0.6989894509315491, "1996": 0.33115679025650024, "2002": 0.43812891840934753, "2003": 0.25845035910606384, "2013": 0.4950772523880005, "2015": 0.1808556467294693, "2029": 0.07793712615966797, "2034": 0.5483922958374023, "2037": 0.10203468054533005, "2054": 0.09761575609445572, "2073": 0.12038381397724152, "208... | 34982259 | The hematopoietic system is one of the first complex tissues to develop in the mammalian conceptus. Of particular interest in the field of developmental hematopoiesis is the origin of adult bone marrow hematopoietic stem cells. Tracing their origin is complicated because blood is a mobile tissue and because hematopoiet... | Of lineage and legacy: the development of mammalian hematopoietic stem cells |
{"2003": 0.18004031479358673, "2004": 0.04860413447022438, "2007": 0.08692999184131622, "2011": 0.25239890813827515, "2015": 0.04487626627087593, "2034": 0.42416930198669434, "2037": 0.08244366943836212, "2038": 0.2145126610994339, "2042": 0.28743788599967957, "2046": 0.2786078155040741, "2049": 0.034552380442619324, "... | 35004872 | Asbestos has been described as a physical carcinogen in that its carcinogenic effects appear to be related primarily to fiber dimensions. It has been hypothesized that long asbestos fibers may interfere with chromosome distribution during cell division, causing genomic changes that lead to cell transformation and neopl... | Long crocidolite asbestos fibers cause polyploidy by sterically blocking cytokinesis. |
{"1056": 0.8366385698318481, "1156": 0.6139179468154907, "1996": 0.07068414986133575, "1999": 0.025073638185858727, "2001": 0.04953393340110779, "2011": 0.17840765416622162, "2013": 0.36086538434028625, "2029": 0.00875066313892603, "2034": 0.0842406153678894, "2042": 0.02412080205976963, "2076": 0.4067663550376892, "20... | 35008773 | In vertebrates, the development of the nervous system is triggered by signals from a powerful 'organizing' region of the early embryo during gastrulation. This phenomenon--neural induction--was originally discovered and given conceptual definition by experimental embryologists working with amphibian embryos. Work on th... | Neural induction and early patterning in vertebrates. |
{"1043": 0.32764431834220886, "1057": 0.18978065252304077, "2003": 0.0038986403960734606, "2005": 0.05046287178993225, "2040": 0.020300358533859253, "2045": 0.2223619967699051, "2054": 0.03266380727291107, "2055": 0.15693697333335876, "2057": 0.006812678650021553, "2060": 0.1011524572968483, "2073": 0.3622259199619293,... | 35022568 | Recent years have seen the emergence of a 'global mental health' agenda, focused on providing evidence-based interventions for mental illnesses in low- and middle-income countries. Anthropologists and cultural psychiatrists have engaged in vigorous debates about the appropriateness of this agenda. In this article, we r... | What's in the 'treatment gap'? Ethnographic perspectives on addiction and global mental health from China, Russia, and the United States. |
{"1011": 0.2247048318386078, "1015": 0.1229778528213501, "1017": 0.630689799785614, "1022": 0.9162907600402832, "1040": 0.18573370575904846, "1043": 0.5127768516540527, "1047": 1.1205062866210938, "1998": 0.12642613053321838, "2003": 0.0317181795835495, "2008": 0.18004031479358673, "2024": 0.1889725625514984, "2029": 0... | 35062452 | Krüppel-like factors 3 and 8 (KLF3 and KLF8) are highly related transcriptional regulators that bind to similar sequences of DNA. We have previously shown that in erythroid cells there is a regulatory hierarchy within the KLF family, whereby KLF1 drives the expression of both the Klf3 and Klf8 genes and KLF3 in turn re... | Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. |
{"1017": 0.026025565341114998, "1020": 0.09850110858678818, "1038": 0.011650617234408855, "1049": 0.6911921501159668, "1052": 0.18411032855510712, "1055": 0.20739519596099854, "1996": 0.09495500475168228, "1999": 0.05139094591140747, "2011": 0.09050461649894714, "2025": 0.10203468054533005, "2026": 0.9155091643333435, ... | 35079452 | The ability of Mycobacterium tuberculosis to enter host macrophages, and reside in a phagosome, which does not mature into a phagolysosome, is central to the spread of tuberculosis and the associated pandemic involving billions of people worldwide. Tuberculosis can be viewed as a disease with a significant intracellula... | Mycobacterium tuberculosis phagosome maturation arrest: selective targeting of PI3P-dependent membrane trafficking. |
{"1011": 0.11517547070980072, "1039": 0.1734936386346817, "1045": 0.0606246218085289, "1047": 0.6603899002075195, "1048": 0.08692999184131622, "1058": 0.015504186972975731, "2001": 0.06703783571720123, "2003": 0.15777134895324707, "2011": 0.3423145115375519, "2029": 0.14686977863311768, "2033": 0.6363908052444458, "205... | 35085326 | A previously unknown protein, designated SvpA (surface virulence-associated protein) and implicated in the virulence of the intracellular pathogen Listeria monocytogenes, was identified. This 64 kDa protein, encoded by svpA, is both secreted in culture supernatants and surface-exposed, as shown by immunogold labelling ... | SvpA, a novel surface virulence-associated protein required for intracellular survival of Listeria monocytogenes. |
{"1044": 0.4568560719490051, "1245": 0.09317722171545029, "2002": 0.5255602598190308, "2003": 0.2493593990802765, "2005": 0.14939609169960022, "2038": 0.12038381397724152, "2109": 0.27712854743003845, "2152": 0.3560888469219208, "2154": 0.2983669638633728, "2169": 0.040196798741817474, "2224": 0.007782140281051397, "23... | 35087728 | Highly active antiretroviral therapy (HAART) has radically changed the course of HIV disease, producing substantial reductions in both HIV-related morbidity and mortality. However, the complexity of the typical daily HAART regimen is substantial, and high levels of adherence are essential for complete and long-term vir... | Measuring adherence to highly active antiretroviral therapy: implications for research and practice. |
{"1003": 0.20022670924663544, "2015": 0.37035053968429565, "2073": 0.17267228662967682, "2084": 0.21214580535888672, "2086": 0.16276304423809052, "2088": 0.14518201351165771, "2109": 0.3949938118457794, "2116": 0.4286321699619293, "2137": 0.5341835021972656, "2146": 0.4400174915790558, "2155": 0.14095009863376617, "216... | 35100235 | Mark-recapture data collected using mist nets over a 10-yr period in Trinidad were used to estimate adult survival rates for 17 species of forest passerines. Trinidadian survival rates (mean 65%, range 45%-85%) were significantly higher than published estimates for European (mean survival 52%, range 32%-71%) and North ... | Survival rates of tropical and temperate passerines: a Trinidadian perspective. |
{"1011": 0.0029254043474793434, "1041": 0.3526630103588104, "1045": 0.013579257763922215, "1052": 0.997294545173645, "1999": 0.4145384132862091, "2010": 0.6853039860725403, "2012": 0.34300774335861206, "2026": 0.854249119758606, "2029": 0.24325250089168549, "2033": 0.129004567861557, "2043": 0.15526613593101501, "2044"... | 35149431 | Two synthetic peripheral nerve myelin P0 protein peptides, an immunodominant (amino acids 180-199) and a cryptic (amino acids 56-71) one, induced an acute or chronic course of experimental autoimmune neuritis (EAN) in Lewis rats, when given at low dose (50-100 microg/rat) or high dose (250 microg/rat), respectively. Co... | P0 glycoprotein peptides 56–71 and 180–199 dose-dependently induce acute and chronic experimental autoimmune neuritis in Lewis rats associated with epitope spreading |
{"1039": 0.3339579105377197, "1051": 0.574020504951477, "1998": 0.3241194784641266, "2000": 0.16442140936851501, "2002": 0.75193190574646, "2007": 0.4437839686870575, "2012": 0.06886265426874161, "2044": 0.1358480453491211, "2045": 0.4349733293056488, "2052": 0.12814582884311676, "2055": 0.10731173306703568, "2062": 0.... | 35186640 | There is considerable variation in opinion about the importance of drug interactions between the combined oral contraceptive pill (COCP) and broad-spectrum antibiotics. Clinical practice varies widely, especially between doctors in Europe and those in the US. Rifampicin and griseofulvin induce hepatic enzymes and do ap... | Interaction between broad-spectrum antibiotics and the combined oral contraceptive pill. A literature review. |
{"1011": 0.680370569229126, "1040": 0.5685047507286072, "1041": 0.9348671436309814, "1052": 0.3127557039260864, "1999": 0.029824240133166313, "2003": 0.38905516266822815, "2007": 0.48670899868011475, "2008": 0.13670019805431366, "2011": 0.30989447236061096, "2024": 0.00875066313892603, "2029": 0.32270604372024536, "206... | 35231675 | CLIP-170 is a "cytoplasmic linker protein" implicated in endosome-microtubule interactions and in control of microtubule dynamics. CLIP-170 localizes dynamically to growing microtubule plus ends, colocalizing with the dynein activator dynactin and the APC-binding protein EB1. This shared "plus-end tracking" behavior su... | CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms. |
{"1011": 0.3170322775840759, "1038": 1.0973093509674072, "1042": 0.6296497583389282, "1048": 0.6000806093215942, "1056": 0.40741631388664246, "1996": 0.10993985831737518, "1998": 0.20739519596099854, "1999": 0.08961215615272522, "2000": 0.2659635543823242, "2007": 0.36290550231933594, "2011": 0.4824984669685364, "2013"... | 35256900 | The mechanism of B cell–antigen encounter in lymphoid tissues is incompletely understood. It is also unclear how immune complexes are transported to follicular dendritic cells. Here, using real-time two-photon microscopy we noted rapid delivery of immune complexes through the lymph to macrophages in the lymph node subc... | Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells |
{"1009": 0.40089741349220276, "2026": 0.6186635494232178, "2075": 0.043007105588912964, "2079": 0.20022670924663544, "2084": 0.04207121208310127, "2089": 0.21687394380569458, "2129": 0.037378571927547455, "2147": 0.0058422754518687725, "2169": 0.00875066313892603, "2203": 0.7258110046386719, "2235": 0.22937409579753876... | 35271381 | Aerobic exercise training induces an increase in coronary blood flow capacity that is associated with altered control of coronary vascular resistance and, therefore, coronary blood flow. The relative importance of metabolic, myogenic, endothelium-mediated, and neurohumoral control systems varies throughout the coronary... | Exercise training-induced adaptations in the coronary circulation. |
{"1014": 0.17840765416622162, "1042": 0.7333439588546753, "1044": 0.08961215615272522, "1052": 0.672426164150238, "1609": 0.29328158497810364, "1999": 0.040196798741817474, "2001": 0.0842406153678894, "2002": 0.8813109993934631, "2004": 0.040196798741817474, "2007": 0.15526613593101501, "2039": 0.11343330889940262, "20... | 35301079 | BACKGROUND In uveal melanoma (UM) with metastatic disease limited to the liver, the effect of an intrahepatic treatment on survival is unknown. We investigated prospectively the efficacy and toxicity of hepatic intra-arterial (HIA) versus systemic (IV) fotemustine in patients with liver metastases from UM. PATIENTS AND... | Hepatic intra-arterial versus intravenous fotemustine in patients with liver metastases from uveal melanoma (EORTC 18021): a multicentric randomized trial. |
{"1003": 0.0058422754518687725, "1014": 0.13499516248703003, "1017": 0.06337817758321762, "1022": 0.09406650811433792, "1039": 0.9546096324920654, "1043": 0.7182208299636841, "1052": 0.40220460295677185, "2001": 0.016465263441205025, "2007": 0.17267228662967682, "2044": 0.11517547070980072, "2051": 0.7389566898345947, ... | 35314705 | BACKGROUND Cerebellar glioblastoma multiforme (cGBM) is rare, and although there is a general belief that these tumors have a worse prognosis than supratentorial GBM (sGBM), few studies have been published to support this belief. OBJECTIVE To investigate the effect of cerebellar location on survival through a case-cont... | Comparison of survival between cerebellar and supratentorial glioblastoma patients: surveillance, epidemiology, and end results (SEER) analysis. |
{"1039": 0.6999598741531372, "1055": 0.2652147710323334, "1996": 0.15610189735889435, "1998": 0.1619328260421753, "1999": 0.14264501631259918, "2001": 0.018384648486971855, "2005": 0.13499516248703003, "2007": 0.15526613593101501, "2010": 0.6573580503463745, "2011": 0.3588210940361023, "2013": 0.5957841277122498, "2015... | 35321950 | During a certain period of the course of infection in white mice inoculated intraperitoneally with the pure culture of a proteolysing strain of Candida albicans, Staphylococcus aureus and C. albicans both, were isolated simultaneously from the peritoneal abscesses, especially those adhering to the stomach, duodenum, pa... | Staphylococcus aureus and Candida albicans infection (animal experiments). |
{"1011": 0.21135559678077698, "1016": 0.0913962796330452, "1028": 0.18978065252304077, "1038": 0.659380316734314, "1039": 0.7028654217720032, "1044": 0.7463917136192322, "1055": 0.7105726003646851, "1056": 0.7124901413917542, "1998": 0.025073638185858727, "1999": 0.15777134895324707, "2002": 0.9005423784255981, "2006":... | 35329820 | Emerging evidences have shown that common genetic polymorphisms in microRNAs may be associated with the development of hepatocellular carcinoma (HCC); but individually published studies and previous meta-analyses revealed inconclusive results. The aims of this review and meta-analysis are to assess whether common singl... | Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis. |
{"1006": 0.28450319170951843, "1009": 0.9209672808647156, "1011": 0.25995752215385437, "1052": 0.36697331070899963, "1999": 0.06246116757392883, "2003": 0.4067663550376892, "2004": 0.012615402229130268, "2005": 0.10906458646059036, "2008": 0.1510767638683319, "2011": 0.5370414853096008, "2012": 0.15693697333335876, "20... | 35345807 | Sirtuins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD(+) concentration through the combined action of NAD(+) biosynthesis and... | Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration. |
{"1021": 0.32764431834220886, "1022": 0.5844172835350037, "1039": 0.3784096837043762, "1043": 0.26446542143821716, "1050": 0.7463917136192322, "1056": 0.8109301924705505, "1998": 0.20660123229026794, "2004": 0.24325250089168549, "2008": 0.13499516248703003, "2011": 0.4734157919883728, "2013": 0.18978065252304077, "2014... | 35395662 | The virally encoded chemokine receptors US28 from human cytomegalovirus and ORF74 from human herpesvirus 8 are both constitutively active. We show that both receptors constitutively activate the transcription factors nuclear factor of activated T cells (NFAT) and cAMP response element binding protein (CREB) and that bo... | Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74. |
{"1039": 0.822151780128479, "2003": 0.3353555500507355, "2008": 0.01934296265244484, "2011": 0.012615402229130268, "2024": 0.43623676896095276, "2054": 0.15860503911972046, "2079": 0.1718502640724182, "2083": 0.01934296265244484, "2109": 0.14179791510105133, "2179": 0.06246116757392883, "2278": 1.2802826166152954, "231... | 35443524 | Cancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor initiation and self-renewal capacity and the ability to give rise to bulk populations of nontumorigenic cancer cell progeny through differentiation. As we discuss here, they have been prospectively identified in several human mal... | The therapeutic promise of the cancer stem cell concept. |
{"1005": 0.23556606471538544, "1011": 0.21293537318706512, "1017": 0.7473171949386597, "1020": 0.06795065850019455, "1037": 0.02792670577764511, "1996": 0.052318159490823746, "1997": 0.25694093108177185, "1998": 0.0058422754518687725, "1999": 0.045809537172317505, "2004": 0.056018441915512085, "2007": 0.278607815504074... | 35448676 | 3'-Ends of almost all eukaryotic mRNAs are generated by endonucleolytic cleavage and addition of a poly(A) tail. In mammalian cells, the reaction depends on the sequence AAUAAA upstream of the cleavage site, a degenerate GU-rich sequence element downstream of the cleavage site and stimulatory sequences upstream of AAUA... | 3'-End processing of pre-mRNA in eukaryotes. |
{"1011": 0.15693697333335876, "1017": 0.09317722171545029, "1049": 0.4228905141353607, "1996": 0.0913962796330452, "1997": 0.004870930220931768, "2003": 0.07341018319129944, "2008": 0.1619328260421753, "2015": 0.05786345899105072, "2026": 1.072225570678711, "2029": 0.2741633653640747, "2033": 0.4920966327190399, "2046"... | 35467590 | We have identified a novel transcription unit of 105 kilobases (called the Golli-mbp gene) that encompasses the mouse myelin basic protein (MBP) gene. Three unique exons within this gene are alternatively spliced into MBP exons and introns to produce a family of MBP gene-related mRNAs that are under individual developm... | Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain. |
{"1014": 0.46608972549438477, "1016": 0.9568626880645752, "1043": 0.4920966327190399, "1044": 0.07068414986133575, "2001": 0.00875066313892603, "2005": 0.12384103983640671, "2007": 0.32058215141296387, "2026": 0.3963087201118469, "2039": 0.07068414986133575, "2048": 0.5290185213088989, "2052": 0.2576959431171417, "2058... | 35495268 | BACKGROUND Weight loss is recommended for overweight or obese patients with type 2 diabetes on the basis of short-term studies, but long-term effects on cardiovascular disease remain unknown. We examined whether an intensive lifestyle intervention for weight loss would decrease cardiovascular morbidity and mortality am... | Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. |
{"1006": 0.0058422754518687725, "1011": 0.21530038118362427, "1015": 0.004870930220931768, "1017": 0.2696990668773651, "1037": 0.10906458646059036, "1040": 0.3982778787612915, "1043": 0.4267219603061676, "1047": 0.3346569836139679, "2010": 0.7124901413917542, "2012": 0.016465263441205025, "2020": 0.09406650811433792, "... | 35520219 | Unilateral injection of kainic acid (KA) into the dorsal hippocampus of adult mice induces spontaneous recurrent partial seizures and replicates histopathological changes observed in human mesial temporal lobe epilepsy (MTLE) (Bouilleret V et al., Neuroscience 1999; 89:717-729). Alterations in pre- and postsynaptic com... | Early loss of interneurons and delayed subunit-specific changes in GABA(A)-receptor expression in a mouse model of mesial temporal lobe epilepsy. |
{"1020": 0.05694137513637543, "1054": 0.35403475165367126, "1996": 0.08244366943836212, "2012": 0.13755162060260773, "2015": 0.32270604372024536, "2034": 0.18492233753204346, "2043": 0.00875066313892603, "2044": 0.3191637098789215, "2076": 0.6410312056541443, "2077": 0.00875066313892603, "2079": 0.06886265426874161, "2... | 35521287 | The cardiorespiratory control system undergoes functional maturation after birth. Until this process is completed, the cardiorespiratory system is unstable, placing infants at risk for cardiorespiratory disturbances, especially during sleep. The profound influence of states of alertness on respiratory and cardiac contr... | Cardiorespiratory adaptation during sleep in infants and children. |
{"1011": 0.25845035910606384, "1015": 0.19622190296649933, "1017": 0.12814582884311676, "1039": 0.4794800877571106, "1047": 0.5882205963134766, "1050": 0.19622190296649933, "1157": 0.5162794589996338, "1996": 0.036437395960092545, "1997": 0.18329764902591705, "1999": 0.0842406153678894, "2004": 0.030771657824516296, "2... | 35531883 | Nearly all members of the inwardly rectifying potassium (Kir) channel family share a cytoplasmic domain structure that serves as an unusual AP-1 clathrin adaptor-dependent Golgi export signal in one Kir channel, Kir2.1 (KCNJ2), raising the question whether Kir channels share a common Golgi export mechanism. Here we exp... | A Common Signal Patch Drives AP-1 Protein-dependent Golgi Export of Inwardly Rectifying Potassium Channels. |
{"1011": 0.10203468054533005, "1039": 0.10026945173740387, "2003": 0.1229778528213501, "2015": 0.43875885009765625, "2026": 0.9139442443847656, "2046": 0.1970241367816925, "2166": 0.14686977863311768, "2331": 0.3012613356113434, "2350": 0.6000806093215942, "2361": 0.19782574474811554, "2378": 0.6254787445068359, "2497"... | 35534019 | Thrombohaemorrhagic complications are major clinical problems in the classical chronic Ph-negative myeloproliferative disorders (CMPDs), polycytaemia vera (PV), essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF), contributing significantly to morbidity and mortality. Pathophysiologically these disorders... | Statins in the treatment of polycythaemia vera and allied disorders: an antithrombotic and cytoreductive potential? |
{"1043": 0.4734157919883728, "1052": 0.1229778528213501, "2003": 0.16607704758644104, "2006": 0.7105726003646851, "2039": 0.12470348179340363, "2046": 0.009718249551951885, "2063": 0.14518201351165771, "2076": 0.46117570996284485, "2079": 0.030771657824516296, "2124": 0.18411032855510712, "2135": 0.5860490798950195, "2... | 35543846 | Cellular senescence is considered a major tumour-suppressor mechanism in mammals, and many oncogenic insults, such as the activation of the ras proto-oncogene, trigger initiation of the senescence programme. Although it was shown that activation of the senescence programme involves the up-regulation of cell-cycle regul... | Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. |
{"1009": 0.1693800985813141, "1011": 0.3723714053630829, "1017": 0.38308101892471313, "1044": 0.8666408061981201, "1048": 0.4196864068508148, "1050": 0.6112717390060425, "1056": 0.5882205963134766, "1996": 0.018384648486971855, "1997": 0.1384023278951645, "1999": 0.11256109178066254, "2002": 0.7791815400123596, "2005":... | 35612665 | Using expression cloning, we have identified an H2-M3-restricted epitope of the intracellular bacterial pathogen Listeria monocytogenes. Picomolar concentrations of an amino-terminal N-formylated hexapeptide, fMIGWII, targeted cells for lysis by CD8+ cytotoxic T cells, while the nonformylated peptide was approximately ... | Identification of an H2-M3-restricted Listeria epitope: implications for antigen presentation by M3. |
{"1014": 0.2954642176628113, "1016": 0.6892333030700684, "1026": 0.20022670924663544, "1038": 0.9100211262702942, "1050": 0.19541899859905243, "1052": 0.42096930742263794, "1056": 0.8161250352859497, "1081": 0.6911921501159668, "2007": 0.12038381397724152, "2011": 0.015504186972975731, "2012": 0.06612417846918106, "204... | 35621259 | CONTEXT Cross-sectional epidemiological studies have found that patients with type 2 diabetes mellitus (T2DM) have a higher incidence of certain fragility fractures despite normal or elevated bone mineral density (BMD). OBJECTIVE In this study, high-resolution peripheral quantitative computed tomography was applied to ... | High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus. |
{"1011": 0.175953671336174, "1039": 0.5104349255561829, "1055": 0.33675122261047363, "1056": 0.9440274834632874, "1999": 0.11517547070980072, "2003": 0.19782574474811554, "2005": 0.2719337046146393, "2008": 0.14518201351165771, "2012": 0.06612417846918106, "2029": 0.24859806895256042, "2034": 0.029824240133166313, "206... | 35651106 | Efficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in CD28 expression (CD28-/- mice) to analyze the role of CD28 in the immune response against the intracellular bacterium Salmonella typhimu... | Critical role of CD28 in protective immunity against Salmonella typhimurium. |
{"1011": 0.3423145115375519, "1016": 0.034552380442619324, "1017": 0.20977331697940826, "1040": 0.2763880789279938, "1043": 0.3353555500507355, "1052": 0.07884006202220917, "1054": 0.4624064862728119, "1999": 0.029824240133166313, "2007": 0.026025565341114998, "2011": 0.30558720231056213, "2026": 0.8989537954330444, "2... | 35660758 | Phorbol 12-myristate 13-acetate (PMA) uncaps a small number of the fast-growing (barbed) ends of actin filaments, thereby eliciting slow actin assembly and extension of filopodia in human blood platelets. These reactions, which also occur in response to immunologic perturbation of the integrin glycoprotein (GP) IIb-III... | D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. |
{"1011": 0.11951763927936554, "1015": 0.08692999184131622, "1017": 0.13755162060260773, "1039": 0.19862671196460724, "1041": 0.4764525294303894, "1052": 0.9485763907432556, "1058": 0.1751343309879303, "2005": 0.15359249711036682, "2025": 0.23633737862110138, "2029": 0.05046287178993225, "2031": 0.0606246218085289, "203... | 35684881 | Tumor-derived p53 mutants can transcriptionally activate a number of promoters of genes involved in cellular proliferation. For this transactivation, mutant p53 does not use the wild-type p53 DNA-binding site, suggesting a mechanism of transactivation that is independent of direct DNA binding. Here we describe our anal... | `Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain |
{"1005": 0.10379679501056671, "1038": 0.5370414853096008, "1041": 0.6425731778144836, "1047": 0.3824150264263153, "1048": 0.41065993905067444, "1049": 0.3560888469219208, "2001": 0.015504186972975731, "2003": 0.14686977863311768, "2004": 0.3012613356113434, "2011": 0.12038381397724152, "2013": 0.43938836455345154, "202... | 35711485 | Banana streak disease is caused by several distinct badnavirus species, one of which is Banana streak Obino l'Ewai virus. Banana streak Obino l'Ewai virus has severely hindered international banana (Musa spp.) breeding programmes, as new hybrids are frequently infected with this virus, curtailing any further exploitati... | Banana contains a diverse array of endogenous badnaviruses. |
{"1014": 0.42353010177612305, "1015": 0.7389566898345947, "1019": 0.20501139760017395, "1020": 0.1930064558982849, "1023": 0.006812678650021553, "1044": 0.49030399322509766, "1045": 0.03360854089260101, "1056": 0.6425731778144836, "2001": 0.38308101892471313, "2007": 0.22859740257263184, "2018": 0.07250232994556427, "2... | 35714909 | OBJECTIVE In 1989 the St. Vincent declaration set a five-year target for approximating outcomes of pregnancies in women with diabetes to those of the background population. We investigated and quantified the risk of adverse pregnancy outcomes in pregnant women with type 1 diabetes (T1DM) to evaluate if the goals of the... | Pregnancy in women with type 1 diabetes: have the goals of St. Vincent declaration been met concerning foetal and neonatal complications? |
{"1040": 0.00875066313892603, "1044": 0.7028654217720032, "1047": 0.06337817758321762, "1048": 0.33115679025650024, "1058": 0.31845372915267944, "1998": 0.052318159490823746, "2007": 0.32341301441192627, "2019": 0.4926934838294983, "2039": 0.0842406153678894, "2044": 0.025073638185858727, "2058": 0.056018441915512085, ... | 35724562 | In adult patients with CKD, hypertension is linked to the development of left ventricular hypertrophy, but whether this association exists in children with CKD has not been determined conclusively. To assess the relationship between BP and left ventricular hypertrophy, we prospectively analyzed data from the Chronic Ki... | BP control and left ventricular hypertrophy regression in children with CKD. |
{"1011": 0.2478361576795578, "1047": 0.659380316734314, "1048": 0.13157635927200317, "1050": 0.07250232994556427, "1052": 0.28082266449928284, "1055": 0.7380234599113464, "1056": 0.47463157773017883, "1999": 0.052318159490823746, "2003": 0.25088030099868774, "2004": 0.2637155055999756, "2008": 0.18654440343379974, "201... | 35747505 | Nicotinic acid adenine dinucleotide phosphate (NAADP) is a messenger that regulates calcium release from intracellular acidic stores. Although several channels, including two-pore channels (TPC), ryanodine receptor (RYR) and mucolipin (TRP-ML1) have been implicated in NAADP regulation of calcium signaling, the NAADP re... | Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes. |
{"1011": 0.1332872211933136, "1013": 0.15693697333335876, "1015": 0.5174443125724792, "1039": 0.3339579105377197, "1041": 0.4145384132862091, "1058": 0.07250232994556427, "1999": 0.02316705882549286, "2007": 0.19381128251552582, "2013": 0.1994270235300064, "2028": 0.25239890813827515, "2029": 0.13499516248703003, "2039... | 35760786 | The ARV1-encoded protein mediates sterol transport from the endoplasmic reticulum (ER) to the plasma membrane. Yeast ARV1 mutants accumulate multiple lipids in the ER and are sensitive to pharmacological modulators of both sterol and sphingolipid metabolism. Using fluorescent and electron microscopy, we demonstrate ste... | Loss of subcellular lipid transport due to ARV1 deficiency disrupts organelle homeostasis and activates the unfolded protein response. |
{"1011": 0.2493593990802765, "1015": 0.1808556467294693, "1017": 0.32764431834220886, "1045": 0.5381823778152466, "1156": 0.3757305145263672, "1999": 0.08513788133859634, "2004": 0.011650617234408855, "2005": 0.08603433519601822, "2007": 0.11517547070980072, "2008": 0.2394166737794876, "2011": 0.13925230503082275, "201... | 35764259 | Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that li... | IL-28, IL-29 and their class II cytokine receptor IL-28R |
{"1011": 0.1619328260421753, "1017": 0.09317722171545029, "1018": 0.2741633653640747, "1039": 0.47584590315818787, "1044": 0.12728634476661682, "1999": 0.38308101892471313, "2000": 0.11604541540145874, "2004": 0.3956514894962311, "2005": 0.27564704418182373, "2007": 0.3850763738155365, "2012": 0.37640097737312317, "202... | 35766603 | PURPOSE To determine the toxicity and the therapeutic efficacy of the combination of the recombinant tumor necrosis factor alpha (rTNF alpha), recombinant interferon gamma (rIFN-gamma), and melphalan, we designed a protocol using isolation limb perfusion (ILP) with hyperthermia for in-transit metastases of melanoma and... | High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. |
{"1009": 0.15275461971759796, "1020": 0.02792670577764511, "1022": 0.37907835841178894, "1023": 0.03360854089260101, "1039": 0.18573370575904846, "1042": 0.06886265426874161, "1043": 0.18411032855510712, "1049": 0.3416208028793335, "1055": 0.0913962796330452, "1997": 0.045809537172317505, "1999": 0.15442965924739838, "... | 35768199 | Methanosphaera stadtmaniae is a non-motile, Gram-positive spherical-shaped organism that obtains energy for growth by using hydrogen to reduce methanol to methane. It does not produce methane from hydrogen and carbon dioxide, formate, acetate or methylamines and cannot grow with hydrogen and carbon monoxide, nitrate, f... | Methanosphaera stadtmaniae gen. nov., sp. nov.: a species that forms methane by reducing methanol with hydrogen |
{"1039": 0.08603433519601822, "1047": 0.4132472574710846, "2002": 0.47827014327049255, "2003": 0.1011524572968483, "2005": 0.3723714053630829, "2008": 0.0752234235405922, "2011": 0.21372433006763458, "2012": 0.19862671196460724, "2013": 0.5773153901100159, "2015": 1.1994705200195312, "2024": 0.22079704701900482, "2026"... | 35777860 | Induced pluripotent stem (iPS) cells derived from disease patients are an invaluable resource for biomedical research and may provide a source for replacement therapies. In this study, we have generated iPS cells from Asian patients with chronic degenerative diseases of the nervous system, including spinal muscular atr... | Generation of induced pluripotent stem cells from Asian patients with chronic neurodegenerative diseases. |
{"1009": 0.1510767638683319, "1011": 0.2954642176628113, "1014": 0.24248650670051575, "1020": 0.05694137513637543, "1040": 0.2689530849456787, "1041": 0.5816917419433594, "1042": 0.10379679501056671, "1049": 0.5893046259880066, "1998": 0.04207121208310127, "2004": 0.06612417846918106, "2005": 0.41647201776504517, "2007... | 35811036 | Embryonic-like stem cell (ELSC), expressing part of surface markers of human embryonic stem cells, may be a better candidate for cell therapy of degenerative muscular disease than mesenchymal stem cell (MSC). We isolated ELSC and MSC from bone marrow, respectively, and compared their differences in the characteristics ... | Embryonic-like stem cell derived from adult bone marrow: immature morphology, cell surface markers, ultramicrostructure and differentiation into multinucleated fibers in vitro. |
{"1006": 0.0317181795835495, "1011": 0.3443928062915802, "1021": 0.025073638185858727, "1997": 0.083342544734478, "1999": 0.08513788133859634, "2004": 0.18167030811309814, "2005": 0.07068414986133575, "2008": 0.15023678541183472, "2011": 0.4267219603061676, "2026": 0.6389714479446411, "2028": 0.17267228662967682, "2029... | 35828148 | Apocynin has been reported to require dimerization by myeloperoxidase (MPO) to inhibit leukocyte NADPH oxidase. (-)-Epicatechin, a dietary flavan-3-ol, has been identified as a 'prodrug' of apocynin-like metabolites that inhibit endothelial NADPH oxidase activity and elevate the cellular level of nitric oxide. Since (-... | Kinetic evidence for rapid oxidation of (-)-epicatechin by human myeloperoxidase. |
{"1011": 0.23247487843036652, "1039": 0.0354953333735466, "1042": 0.09317722171545029, "1043": 0.19862671196460724, "1055": 0.3381449282169342, "2000": 0.18654440343379974, "2003": 0.0174254160374403, "2005": 0.17267228662967682, "2007": 0.16607704758644104, "2008": 0.00875066313892603, "2015": 0.0058422754518687725, "... | 35861290 | Substitute Teacher Despite the relative ease of genome manipulation in S. cerevisiae, researchers are always looking to learn still more convenient and rapid methods for substituting yeast promoters. Replacing a gene's native promoter with a heterolo-gous promoter of choice allows regulated expression and simplifies th... | Using the yeast gene deletion collection to customize gene expression. |
{"1039": 0.29109421372413635, "1043": 0.6553317308425903, "1052": 0.015504186972975731, "1997": 0.04113444685935974, "2003": 0.09317722171545029, "2005": 0.1751343309879303, "2006": 0.1905880719423294, "2011": 0.36086538434028625, "2029": 0.22782009840011597, "2050": 0.9348671436309814, "2076": 0.007782140281051397, "2... | 35884026 | Phosphorylation of AMPA receptors is a major mechanism for the regulation of receptor function and underlies several forms of synaptic plasticity in the CNS. Although serine and threonine phosphorylation of AMPA receptors has been well studied, the potential role of tyrosine phosphorylation of AMPA receptors has not be... | Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases. |
{"1011": 0.18654440343379974, "1037": 0.1602703034877777, "1039": 0.5696102976799011, "1156": 0.7028654217720032, "1998": 0.1889725625514984, "1999": 0.04487626627087593, "2002": 0.8383291959762573, "2004": 0.0913962796330452, "2006": 0.04767346754670143, "2007": 0.18492233753204346, "2011": 0.3241194784641266, "2029":... | 35962023 | Recent studies suggest a close relationship between cell metabolism and apoptosis. We have evaluated changes in lipid metabolism on permeabilized hepatocytes treated with truncated Bid (tBid) in the presence of caspase inhibitors and exogenous cytochrome c. The measurement of β-oxidation flux by labeled palmitate demon... | tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1 |
{"1009": 1.0361549854278564, "1011": 0.1889725625514984, "1015": 0.6280876994132996, "1018": 0.016465263441205025, "1022": 0.6461620330810547, "1039": 0.3106105625629425, "1056": 1.072225570678711, "2011": 0.3464667797088623, "2015": 0.2918238639831543, "2028": 0.18654440343379974, "2029": 0.3177432417869568, "2043": 0... | 35987381 | Hyperactivation of T cells, particularly of CD8(+) T cells, is a hallmark of chronic HIV 1 (HIV-1) infection. Little is known about the antigenic specificities and the mechanisms by which HIV-1 causes activation of CD8(+) T cells during chronic infection. We report that CD8(+) T cells were activated during in vivo HIV-... | CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals. |
{"1011": 0.1011524572968483, "1019": 0.10379679501056671, "1021": 0.18004031479358673, "1039": 0.7009293437004089, "1044": 0.40546512603759766, "1056": 0.5151132941246033, "1156": 0.57457035779953, "1999": 0.12728634476661682, "2002": 0.8004589080810547, "2012": 0.176772341132164, "2015": 0.4437839686870575, "2029": 0.... | 35993767 | Fibroblasts are rich in the surrounding microenvironment of hepatocellular carcinoma (HCC) because most HCCs occur in fibrotic or cirrhotic livers. However, the role of cancer-associated fibroblasts (CAFs) in HCC metastasis remains obscure. Here, we reported that CAFs promote the migration and invasion of HCC cells in ... | Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways. |
{"2001": 0.026976587250828743, "2007": 0.29400965571403503, "2012": 0.1994270235300064, "2020": 0.14349138736724854, "2034": 0.010684899985790253, "2041": 0.2852376699447632, "2044": 0.36426326632499695, "2047": 0.3318578004837036, "2053": 0.3241194784641266, "2058": 0.15693697333335876, "2060": 0.43623676896095276, "2... | 36003142 | OBJECTIVE Mortality rates in the year following new antipsychotic medication starts for neuropsychiatric symptoms of dementia were compared with rates after starts of other psychiatric medications. METHOD The retrospective, cohort study used national data from the Department of Veterans Affairs (fiscal years 2001-2005)... | Mortality risk in patients with dementia treated with antipsychotics versus other psychiatric medications. |
{"1043": 0.9029204845428467, "1060": 0.5139457583427429, "1997": 0.055094651877880096, "1999": 0.04394211992621422, "2005": 0.25694093108177185, "2007": 0.1485546976327896, "2011": 0.2089812457561493, "2029": 0.15693697333335876, "2079": 0.319873183965683, "2087": 0.3963087201118469, "2109": 0.19622190296649933, "2179"... | 36025357 | This review is the introduction to a special issue concerning, glutathione (GSH), the most abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles in protecting cells from oxidative damage and the toxicity of xenobiotic electrophiles, and maintaining redox homeostasis. Here, the func... | Glutathione: overview of its protective roles, measurement, and biosynthesis. |
{"1003": 0.3269403576850891, "1014": 0.259204238653183, "1017": 0.15023678541183472, "1020": 0.043007105588912964, "1040": 0.10818854719400406, "1052": 0.2689530849456787, "1056": 0.22782009840011597, "1058": 0.2089812457561493, "1997": 0.025073638185858727, "1999": 0.6265231370925903, "2000": 0.17431432008743286, "200... | 36033696 | OBJECTIVE The purpose of this project was to educate inpatients with psychotic disorders, many of whom were taking second-generation antipsychotics, about lifestyle changes they can make to combat weight gain. METHOD All inpatients on a Veterans Affairs acute inpatient schizophrenia treatment unit were invited to a 30-... | A wellness class for inpatients with psychotic disorders. |
{"1996": 0.6482070088386536, "2003": 0.09050461649894714, "2005": 0.347847044467926, "2006": 0.036437395960092545, "2011": 0.11865071207284927, "2029": 0.0038986403960734606, "2079": 0.2478361576795578, "2109": 0.18573370575904846, "2124": 0.08064348995685577, "2129": 0.015504186972975731, "2210": 0.00875066313892603, ... | 36066871 | The centromere is essential for the inheritance of genetic information on eukaryotic chromosomes. Epigenetic regulation of centromere identity has been implicated in genome stability, karyotype evolution, and speciation. However, little is known regarding the manner in which centromere dysfunction affects the chromosom... | Heterochromatin integrity affects chromosome reorganization after centromere dysfunction. |
{"1039": 0.1930064558982849, "1040": 0.6254787445068359, "1041": 0.09761575609445572, "1043": 0.21687394380569458, "1996": 0.02316705882549286, "2007": 0.08154398202896118, "2015": 0.3499138653278351, "2029": 0.23710809648036957, "2043": 0.17759032547473907, "2062": 0.27564704418182373, "2073": 0.175953671336174, "2087... | 36082224 | Several human hereditary neurological and neurodegenerative disease genes are associated with the expansion of CTG repeats. Here we show that the frequency of genetic expansions or deletions in Escherichia coli depends on the direction of replication. Large expansions occur predominantly when the CTGs are in the leadin... | Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli |
{"1039": 0.5607312321662903, "1044": 0.011650617234408855, "1050": 0.09938567131757736, "1996": 0.04860413447022438, "1999": 0.009718249551951885, "2004": 0.5080875158309937, "2008": 0.1064341589808464, "2011": 0.24401791393756866, "2015": 0.42353010177612305, "2029": 0.10026945173740387, "2034": 0.19220098853111267, "... | 36089763 | Neutrophils phagocytose and kill microbes upon phagolysosomal fusion. Recently we found that activated neutrophils form extracellular fibres that consist of granule proteins and chromatin. These neutrophil extracellular traps (NETs) degrade virulence factors and kill Gram positive and negative bacteria. Here we show fo... | Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms. |
{"1011": 0.24554696679115295, "1040": 0.037378571927547455, "1041": 0.2852376699447632, "1043": 0.4093637466430664, "1047": 0.026976587250828743, "1052": 0.42799583077430725, "2012": 0.011650617234408855, "2029": 0.1064341589808464, "2037": 0.006812678650021553, "2038": 0.006812678650021553, "2053": 0.1693800985813141,... | 36111909 | Dendrite shape is considered a defining component of neuronal function. Yet, the mechanisms specifying diverse dendritic morphologies, and the extent to which their function depends on these morphologies, remain unclear. Here, we demonstrate a requirement for the microtubule-severing protein katanin p60-like 1 (Kat-60L... | Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. |
{"1020": 0.8065804839134216, "1038": 0.5607312321662903, "1062": 0.10467668622732162, "1998": 0.17020416259765625, "1999": 0.3248254358768463, "2000": 0.23092569410800934, "2005": 0.255429208278656, "2040": 0.5139457583427429, "2043": 0.15693697333335876, "2047": 0.43623676896095276, "2060": 0.4400174915790558, "2062":... | 36124058 | This paper provides an update to the 1998 WHO/UNICEF report on complementary feeding. New research findings are generally consistent with the guidelines in that report, but the adoption of new energy and micronutrient requirements for infants and young children will result in lower recommendations regarding minimum mea... | Update on technical issues concerning complementary feeding of young children in developing countries and implications for intervention programs. |
{"1016": 0.04860413447022438, "1019": 0.3084607720375061, "1020": 0.3070250153541565, "1059": 0.11430477350950241, "2004": 0.3163207769393921, "2007": 0.11604541540145874, "2018": 0.3127557039260864, "2020": 0.1619328260421753, "2031": 0.2918238639831543, "2037": 0.08961215615272522, "2038": 0.04953393340110779, "2043"... | 36178047 | The same 15 male Wistar rats at the ages of 2.5, 6, 10, 14, 18, and 22 months were successively randomly mated with 2.5-month-old females. In a separate experiment, 15 male Wistar rats at the age of 2.5 months and 15 at the age of 23 months were simultaneously randomly mated with 2.5-month-old females. Offspring were e... | Decrease of learning capacity in offspring with increasing paternal age in the rat. |
{"1011": 0.17840765416622162, "1037": 0.5336109399795532, "1038": 0.28082266449928284, "1040": 0.3106105625629425, "1041": 0.13499516248703003, "1048": 0.5404602885246277, "1062": 0.15610189735889435, "1999": 0.10379679501056671, "2004": 0.33115679025650024, "2011": 0.41195443272590637, "2019": 0.26446542143821716, "20... | 36180468 | Proteolytic processing of the beta-amyloid precursor proteins (APP) is required for release of the beta/A4 protein and its deposition into the amyloid plaques characteristic of aging and Alzheimer's disease. We have examined the involvement of acidic intracellular compartments in APP processing in cultured human cells.... | Processing of the beta-amyloid precursor. Multiple proteases generate and degrade potentially amyloidogenic fragments. |
{"1011": 0.4462870955467224, "1013": 0.22782009840011597, "1037": 0.2018241584300995, "1052": 0.7987030148506165, "1057": 0.20977331697940826, "1998": 0.3012613356113434, "2000": 0.021256839856505394, "2003": 0.3027053773403168, "2040": 0.009718249551951885, "2062": 0.007782140281051397, "2064": 0.3297532796859741, "20... | 36202354 | Both to address unmet medical needs and to improve industry competitiveness, regulators in both the United States and the European Union have taken bold steps to translate academic research from the university lab to the patient. A pharmaceutical public-private partnership (PPPP), which is a legally binding contract be... | Pharmaceutical Public-Private Partnerships in the United States and Europe: Moving from the Bench to the Bedside |
{"1050": 0.006812678650021553, "2013": 0.10731173306703568, "2022": 0.4450363218784332, "2028": 0.31132611632347107, "2037": 0.18167030811309814, "2048": 0.22157983481884003, "2073": 0.20660123229026794, "2075": 1.0137293338775635, "2084": 0.09938567131757736, "2092": 0.8433839678764343, "2093": 0.22859740257263184, "2... | 36211049 | This paper examines the effect of one form of chronic stress--household crowding--on psychological well-being, as measured by multiple inverse indicators of psychological well-being. We rely on data from a large (n = 2017) random sample of households in Bangkok, Thailand, a context that has a higher level and broader r... | Chronic stress and psychological well-being: evidence from Thailand on household crowding. |
{"1003": 0.058784693479537964, "1011": 0.16524957120418549, "1017": 0.16110190749168396, "1019": 0.0174254160374403, "1026": 0.2711893916130066, "1041": 0.40806588530540466, "1052": 0.5393219590187073, "1998": 0.029824240133166313, "2006": 0.53589928150177, "2043": 0.0058422754518687725, "2086": 0.4158279001712799, "20... | 36212758 | CONTEXT Gene expression profiling may be useful in examining differences underlying age- and sex-specific outcomes in non-small cell lung cancer (NSCLC). OBJECTIVE To describe clinically relevant differences in the underlying biology of NSCLC based on patient age and sex. DESIGN, SETTING, AND PATIENTS Retrospective ana... | Age- and sex-specific genomic profiles in non-small cell lung cancer. |
{"1011": 0.2145126610994339, "1018": 0.3077431619167328, "1020": 0.2800849378108978, "1054": 0.052318159490823746, "1056": 1.1166772842407227, "2000": 0.11604541540145874, "2005": 0.36426326632499695, "2007": 0.29328158497810364, "2010": 0.5968599319458008, "2064": 0.3949938118457794, "2071": 0.2689530849456787, "2102"... | 36216395 | BACKGROUND & AIMS The therapeutic application of regulatory T cells (Tregs) for the treatment of inflammatory diseases is limited by the scarcity of antigen-specific Tregs. A preferred approach to endow effector T cells (Teff) with a desired specificity uses chimeric immune receptors with antibody-type specificity. Acc... | Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor. |
{"1011": 0.3743882179260254, "1038": 0.3416208028793335, "1047": 0.5506471395492554, "1048": 0.11517547070980072, "1052": 0.09672962874174118, "1054": 0.2531573474407196, "1055": 0.2105647772550583, "1057": 0.24018502235412598, "1997": 0.10731173306703568, "1998": 0.03360854089260101, "1999": 0.22704219818115234, "2007... | 36233757 | In vivo assembly of the Klebsiella aerogenes urease nickel metallocenter requires the presence of UreD, UreF, and UreG accessory proteins and is further facilitated by UreE. Prior studies had shown that urease apoprotein exists in an uncomplexed form as well as in a series of UreD-urease (I.-S. Park, M.B. Carr, and R.P... | Purification and activation properties of UreD-UreF-urease apoprotein complexes. |
{"1009": 0.3423145115375519, "1011": 0.5186077356338501, "1017": 0.3519764244556427, "1018": 0.8780695199966431, "1019": 0.7454653382301331, "1056": 1.0001721382141113, "1996": 0.1677299439907074, "1998": 0.08871890604496002, "1999": 0.11430477350950241, "2004": 0.05786345899105072, "2006": 0.0058422754518687725, "2008... | 36242796 | The cytokines IL-4, IL-13, and IL-5 are markers for the Th2 subset of effector T cells and are often expressed together. These cytokine genes are organized within 140 kb of orthologous DNA in both mouse and human. Using IL-4-expressing CD4+ T cell clones derived from F1 mice, we identified allelic polymorphisms for eac... | Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. |
{"1011": 0.4926934838294983, "1012": 0.09228714555501938, "1056": 1.0815403461456299, "1997": 0.28597161173820496, "1998": 0.2659635543823242, "1999": 0.10291612148284912, "2000": 0.06612417846918106, "2005": 0.2749055027961731, "2011": 0.4938860833644867, "2019": 0.4500300884246826, "2029": 0.18492233753204346, "2060"... | 36271512 | INTRODUCTION • • CELLULAR AND MOLECULAR REQUIREMENTS FOR T-CELL ACTIVATION . The T-Cell Antigen Receptor Complex . . . .. . . . ..... . . . . . . . . . . . . . . . . ...... . . . T-Cell Activation by Antibodies and Leetins . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... | T-cell activation. |
{"1044": 0.4487839937210083, "1048": 0.04674193635582924, "1052": 0.4337083101272583, "2002": 0.09584271162748337, "2005": 0.04674193635582924, "2044": 0.7845434546470642, "2051": 0.2607102394104004, "2053": 0.23864774405956268, "2071": 0.043007105588912964, "2076": 0.15526613593101501, "2077": 0.1011524572968483, "208... | 36288526 | OBJECTIVE The effects of hydroxyethyl starch on bleeding after cardiopulmonary bypass were determined. METHODS A meta-analysis was performed of postoperative blood loss in randomized clinical trials of hydroxyethyl starch versus albumin for fluid management in adult cardiopulmonary bypass surgery. Impacts of hydroxyeth... | Effect of hydroxyethyl starch on bleeding after cardiopulmonary bypass: a meta-analysis of randomized trials. |
{"1040": 0.055094651877880096, "1047": 1.0144377946853638, "1052": 0.3750596046447754, "2003": 0.1734936386346817, "2004": 0.04767346754670143, "2005": 0.006812678650021553, "2006": 0.5584990978240967, "2011": 0.20818853378295898, "2029": 0.19381128251552582, "2038": 0.014542185701429844, "2076": 0.3757305145263672, "2... | 36310858 | Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a viable therapeutic target. We found that the abundance of YAP mRNA, which encodes Yes-associated protein (YAP), a protein regulated by the Hippo ... | Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma |
{"1011": 0.30486753582954407, "1015": 0.36290550231933594, "1016": 0.17840765416622162, "1019": 0.14433705806732178, "1039": 0.40806588530540466, "1050": 0.46670228242874146, "1054": 1.0158531665802002, "1058": 0.5086748600006104, "1999": 0.04113444685935974, "2004": 0.15610189735889435, "2018": 0.3416208028793335, "20... | 36345185 | Rho family proteins are known to regulate actin organization in fibroblasts, but their functions in cells of haematopoietic origin have not been studied in detail. Bac1.2F5 cells are a colony-stimulating factor-1 (CSF-1)-dependent murine macrophage cell line; CSF-1 stimulates their proliferation and motility, and acts ... | Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. |
{"1018": 0.0317181795835495, "1039": 0.4734157919883728, "1050": 0.24018502235412598, "1060": 0.2034190446138382, "1996": 0.07250232994556427, "2002": 0.6275664567947388, "2004": 0.055094651877880096, "2011": 0.3485364317893982, "2012": 0.3012613356113434, "2015": 0.5651806592941284, "2029": 0.043007105588912964, "2037... | 36345578 | Neutrophils have been implicated as harmful cells in a variety of inappropriate inflammatory conditions where they injure the host, leading to the death of the neutrophils and their subsequent phagocytosis by monocytes and macrophages. Here we show that in a fully repairing sterile thermal hepatic injury, neutrophils a... | Visualizing the function and fate of neutrophils in sterile injury and repair |
{"1019": 0.12814582884311676, "1039": 0.32058215141296387, "2001": 0.31489628553390503, "2005": 0.11691460013389587, "2012": 0.3656192123889923, "2020": 0.14349138736724854, "2038": 0.1693800985813141, "2042": 0.31204116344451904, "2043": 0.3877306580543518, "2051": 0.034552380442619324, "2086": 0.4891071021556854, "20... | 36355784 | OBJECTIVE To describe the efficacy of the Finnish mass screening program for cervical squamous carcinoma and adenocarcinoma, as reflected by changes of incidence and mortality rate. METHODS Cervical cancer incidence and mortality data were obtained from the Finnish Cancer Registry. Data were available from the year 195... | The effect of mass screening on incidence and mortality of squamous and adenocarcinoma of cervix uteri. |
{"1011": 0.34922540187835693, "1018": 0.04767346754670143, "1019": 1.1738357543945312, "1044": 1.0229004621505737, "1999": 0.10379679501056671, "2011": 0.3381449282169342, "2012": 0.022212404757738113, "2015": 0.08154398202896118, "2029": 0.20580662786960602, "2038": 0.018384648486971855, "2050": 0.25467249751091003, "... | 36357627 | Serotonin (5-HT) plays a pivotal role in the regulation of the brain-pituitary-adrenal axis. In particular, 5-HT has been shown to control the activity of hypothalamic CRF neurons and pituitary corticotrope cells through activation of 5-HT1A and (or) 5-HT(2A/2C) receptor subtypes. 5-HT, acting through 5-HT2 receptors, ... | Role of 5-HT in the regulation of the brain-pituitary-adrenal axis: effects of 5-HT on adrenocortical cells. |
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