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{"1014": 0.2493593990802765, "1016": 0.06337817758321762, "1017": 0.22937409579753876, "1019": 0.36900100111961365, "1052": 0.4462870955467224, "1998": 0.7473171949386597, "2001": 0.1913948506116867, "2039": 0.055094651877880096, "2042": 0.0606246218085289, "2043": 0.24325250089168549, "2044": 0.10026945173740387, "205... | 32766786 | PURPOSE In the initial report of the Lupron Depot Neoadjuvant Prostate Cancer Study Group patients who received 3 months of androgen deprivation had a significant decrease in the positive margin rate. We monitored these patients for 5 years and to our knowledge present the longest followup of any neoadjuvant trial. MAT... | Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results. |
{"1011": 0.259204238653183, "1040": 0.31132611632347107, "2000": 0.08513788133859634, "2005": 0.176772341132164, "2007": 0.0913962796330452, "2008": 0.04113444685935974, "2013": 0.2089812457561493, "2015": 0.24248650670051575, "2029": 0.09672962874174118, "2038": 0.016465263441205025, "2064": 0.2223619967699051, "2067"... | 32770503 | Massively parallel sequencing of cDNA has enabled deep and efficient probing of transcriptomes. Current approaches for transcript reconstruction from such data often rely on aligning reads to a reference genome, and are thus unsuitable for samples with a partial or missing reference genome. Here we present the Trinity ... | Full-length transcriptome assembly from RNA-Seq data without a reference genome. |
{"1011": 0.0009760859538801014, "1041": 0.4920966327190399, "1044": 0.4950772523880005, "1045": 0.7592713832855225, "2011": 0.2607102394104004, "2029": 0.2800849378108978, "2043": 0.04113444685935974, "2048": 0.46853771805763245, "2050": 0.1808556467294693, "2054": 0.07431721687316895, "2058": 0.5517725944519043, "2075... | 32776084 | Embryonic stem (ES) cell-derived clones and chimeras are often associated with growth abnormalities during fetal development, leading to the production of over/under-weight offspring that show elevated neonatal mortality and morbidity. Due to the role played by imprinted genes in controlling fetal growth, much of the b... | Growth restricted in vitro culture conditions alter the imprinted gene expression patterns of mouse embryonic stem cells. |
{"1049": 0.3248254358768463, "1052": 0.2018241584300995, "1053": 0.02316705882549286, "1997": 0.1718502640724182, "1999": 0.07431721687316895, "2001": 0.08692999184131622, "2003": 0.15023678541183472, "2005": 0.24018502235412598, "2007": 0.18492233753204346, "2028": 0.0797421783208847, "2041": 0.21372433006763458, "204... | 32777637 | BACKGROUND Concurrent use of multiple standing antipsychotics (antipsychotic polypharmacy) is increasingly common among both inpatients and outpatients. Although this has often been cited as a potential quality-of-care problem, reviews of research evidence on antipsychotic polypharmacy have not distinguished between ap... | When is antipsychotic polypharmacy supported by research evidence? Implications for QI. |
{"1014": 0.12384103983640671, "1048": 0.1358480453491211, "1052": 0.22937409579753876, "1079": 0.33325836062431335, "2000": 0.010684899985790253, "2001": 0.010684899985790253, "2002": 0.45870962738990784, "2005": 0.12556517124176025, "2007": 0.03831886500120163, "2018": 0.03266380727291107, "2020": 0.02316705882549286,... | 32787042 | AIM To determine the outcome of patients that underwent liver resection for metastases from uveal melanoma. METHODS Over a 9-year period, patients referred with uveal melanoma metastases were included. Following treatment of primary uveal melanoma, high-risk patients were offered to be enrolled into a 6-monthly non-con... | The Liverpool uveal melanoma liver metastases pathway: outcome following liver resection. |
{"1009": 0.11691460013389587, "1011": 0.35334911942481995, "1014": 0.06612417846918106, "1015": 0.10731173306703568, "1017": 0.026976587250828743, "1038": 0.18654440343379974, "1041": 0.43875885009765625, "1042": 0.567951500415802, "1043": 0.2983669638633728, "1045": 0.04953393340110779, "1052": 0.3127557039260864, "10... | 32797183 | Lineage analysis studies in the avian embryo have identified two types of smooth muscle cells (SMCs) in the tunica media of large elastic arteries; one that originates within the cardiac neural crest and is ectoderm in origin (Ect) and another that arises from local mesenchyme of mesodermal origin (Mes). To determine i... | Smooth muscle lineage diversity in the chick embryo. Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-beta. |
{"1006": 0.11951763927936554, "1015": 0.058784693479537964, "1016": 0.1994270235300064, "1017": 0.2089812457561493, "1019": 0.10467668622732162, "1020": 0.5127768516540527, "1021": 0.22782009840011597, "1022": 0.46608972549438477, "1023": 0.47584590315818787, "1043": 0.12986256182193756, "1044": 0.07884006202220917, "1... | 32827351 | Aqueous solutions of lead salts (1, 2) and saturated solutions of lead hydroxide (1) have been used as stains to enhance the electron-scattering properties of components of biological materials examined in the electron microscope. Saturated solutions of lead hydroxide (1), while staining more intensely than either lead... | THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY |
{"1014": 0.3443928062915802, "1016": 0.7220231294631958, "1048": 0.1332872211933136, "1050": 0.2478361576795578, "1052": 0.6317287683486938, "1998": 0.0770333781838417, "2007": 0.3070250153541565, "2012": 0.08064348995685577, "2025": 0.09850110858678818, "2029": 0.15359249711036682, "2039": 0.00875066313892603, "2043":... | 32850528 | OBJECTIVE To evaluate serum amylase and lipase levels and the rate of acute pancreatitis in patients with type 2 diabetes and high cardiovascular risk randomized to liraglutide or placebo and observed for 3.5-5.0 years. RESEARCH DESIGN AND METHODS A total of 9,340 patients with type 2 diabetes were randomized to either... | Amylase, Lipase, and Acute Pancreatitis in People With Type 2 Diabetes Treated With Liraglutide: Results From the LEADER Randomized Trial. |
{"1011": 0.030771657824516296, "1015": 0.01934296265244484, "1020": 0.03266380727291107, "1043": 0.22392450273036957, "1050": 0.1229778528213501, "1058": 0.25239890813827515, "1062": 1.4255526065826416, "1999": 0.014542185701429844, "2005": 0.25088030099868774, "2006": 0.05786345899105072, "2011": 0.2689530849456787, "... | 32852283 | BACKGROUND Although zoledronic acid (ZOL), a third-generation nitrogen-containing bisphosphonate, has been identified as an attractive therapeutic agent against breast cancer, prostate cancer, multiple myeloma as well as small-cell lung cancer (SCLC), as best as we are aware, the anti-tumor effect of ZOL upon non-small... | Zoledronic acid is unable to induce apoptosis, but slows tumor growth and prolongs survival for non-small-cell lung cancers. |
{"1011": 0.11081436276435852, "2011": 0.42735910415649414, "2015": 0.34715715050697327, "2029": 0.2576959431171417, "2035": 0.009718249551951885, "2050": 0.9650808572769165, "2063": 0.026976587250828743, "2179": 0.015504186972975731, "2278": 0.052318159490823746, "2303": 0.18329764902591705, "2339": 0.03455238044261932... | 32906513 | Recent elucidation of the role of central tolerance in preventing organ-specific autoimmunity has changed our concepts of self/nonself discrimination. This paradigmatic shift is largely attributable to the discovery of promiscuous expression of tissue-restricted self-antigens (TRAs) by medullary thymic epithelial cells... | A central role for central tolerance. |
{"1014": 0.37707099318504333, "1017": 0.06429435312747955, "1044": 0.7701805830001831, "1052": 0.25995752215385437, "1998": 0.0038986403960734606, "2001": 0.13925230503082275, "2002": 0.053244512528181076, "2004": 0.006812678650021553, "2011": 0.19622190296649933, "2013": 0.053244512528181076, "2015": 0.232474878430366... | 32909242 | SETTING The rural health district of Hlabisa, KwaZulu-Natal, South Africa. OBJECTIVES To assess the acceptability and effectiveness of traditional healers as supervisors of tuberculosis (TB) treatment in an existing directly observed treatment, short-course (DOTS) programme. DESIGN An observational study comparing tr... | Contribution of traditional healers to a rural tuberculosis control programme in Hlabisa, South Africa. |
{"1011": 0.14349138736724854, "1016": 0.5640701055526733, "1051": 0.14939609169960022, "1998": 0.5162794589996338, "2004": 0.0038986403960734606, "2007": 0.07159364968538284, "2029": 0.2105647772550583, "2045": 0.13414156436920166, "2048": 0.8332487344741821, "2064": 0.21214580535888672, "2071": 0.06977381557226181, "2... | 32922179 | There are many lines of evidence showing that oxidative stress and aberrant mitogenic changes have important roles in the pathogenesis of Alzheimer's disease (AD). However, although both oxidative stress and cell cycle-related abnormalities are early events, occurring before any cytopathology, the relation between thes... | Alzheimer's disease: the two-hit hypothesis. |
{"1021": 0.8534175157546997, "1039": 0.8633513450622559, "1054": 0.1619328260421753, "1056": 1.0326838493347168, "1996": 0.013579257763922215, "1999": 0.011650617234408855, "2005": 0.4770587682723999, "2008": 0.16690383851528168, "2009": 1.1917895078659058, "2029": 0.3297532796859741, "2049": 0.1873544454574585, "2066"... | 32927401 | Toll-like receptors are typically expressed in immune cells to regulate innate immunity. We found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber primary sensory neurons and was important for inducing itch (pruritus), but was not necessary for eliciting mechanical, thermal, inflammatory and neuropa... | Toll-like receptor 7 mediates pruritus |
{"1011": 0.5133614540100098, "1015": 0.44566190242767334, "1016": 0.07431721687316895, "1037": 0.3956514894962311, "1038": 1.1185935735702515, "1041": 0.42608439922332764, "1043": 0.4067663550376892, "1044": 0.6466736793518066, "1045": 1.0478670597076416, "1049": 0.8861536383628845, "1053": 0.7389566898345947, "1056": ... | 32927475 | Class I-b genes constitute the majority of MHC class I loci. These monomorphic or oligomorphic molecules have been described in many organisms; they are best characterized in the mouse, which contains a substantial number of potentially intact genes. Two main characteristics differentiate class I-b from class I-a molec... | Antigen presentation by major histocompatibility complex class I-B molecules. |
{"1009": 0.6233867406845093, "1040": 0.04394211992621422, "1043": 0.7201237678527832, "1052": 0.01934296265244484, "1062": 0.8425432443618774, "1999": 0.053244512528181076, "2004": 0.022212404757738113, "2008": 0.05786345899105072, "2013": 0.3519764244556427, "2029": 0.2607102394104004, "2046": 0.3127557039260864, "204... | 32955023 | The expansion of white adipose tissue (WAT) in obesity involves de novo differentiation of new adipocytes; however, the cellular origin of these cells remains unclear. Here, we utilize Zfp423(GFP) reporter mice to characterize adipose mural (Pdgfrβ(+)) cells with varying levels of the preadipocyte commitment factor Zfp... | Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice. |
{"1022": 0.011650617234408855, "1997": 0.036437395960092545, "2005": 0.129004567861557, "2015": 0.2539152204990387, "2042": 0.1718502640724182, "2045": 0.3170322775840759, "2055": 0.03266380727291107, "2062": 0.07250232994556427, "2079": 0.35745587944984436, "2092": 0.02412080205976963, "2106": 0.1229778528213501, "210... | 32969964 | Although interest in clinical guidelines has never been greater, uncertainty persists about whether they are effective. The debate has been hampered by the lack of a rigorous overview. We have identified 59 published evaluations of clinical guidelines that met defined criteria for scientific rigour; 24 investigated gui... | Effect of clinical guidelines on medical practice: a systematic review of rigorous evaluations. |
{"1011": 0.022212404757738113, "1037": 0.3870677351951599, "1043": 0.6312094330787659, "1047": 0.7201237678527832, "1056": 0.3519764244556427, "1996": 0.015504186972975731, "1997": 0.14518201351165771, "1999": 0.18004031479358673, "2000": 0.19381128251552582, "2004": 0.22001366317272186, "2005": 0.2749055027961731, "20... | 32975424 | Threonine can be used aerobically as the sole source of carbon and energy by mutants of Escherichia coli K-12. The pathway used involves the conversion of threonine via threonine dehydrogenase to aminoketobutyric acid, which is further metabolized by aminoketobutyric acid ligase, forming acetyl coenzyme A and glycine. ... | Threonine as a carbon source for Escherichia coli. |
{"1001": 0.1718502640724182, "1011": 0.2852376699447632, "1043": 0.02792670577764511, "1050": 0.5751199722290039, "1051": 0.1751343309879303, "1055": 0.6603899002075195, "1997": 0.1994270235300064, "1999": 0.18573370575904846, "2004": 0.1358480453491211, "2008": 0.10906458646059036, "2011": 0.09584271162748337, "2029":... | 32985041 | Nitric oxide (NO) has been linked to numerous physiological and pathophysiological events that are not readily explained by the well established effects of NO on soluble guanylyl cyclase. Exogenous NO S-nitrosylates cysteine residues in proteins, but whether this is an important function of endogenous NO is unclear. He... | Protein S-nitrosylation: a physiological signal for neuronal nitric oxide |
{"1015": 0.3870677351951599, "1016": 0.2531573474407196, "1038": 0.5145297050476074, "1041": 0.7836518287658691, "1043": 0.34715715050697327, "1044": 0.45251765847206116, "1050": 0.5415972471237183, "1051": 0.3897167444229126, "1054": 0.2954642176628113, "2004": 0.3034266233444214, "2011": 0.3910386264324188, "2026": 0... | 33030946 | Summary Hypoxia augments inflammatory responses and osteoclastogenesis by incompletely understood mechanisms. We identified COMMD1 as a cell‐intrinsic negative regulator of osteoclastogenesis that is suppressed by hypoxia. In human macrophages, COMMD1 restrained induction of NF‐&kgr;B signaling and a transcription fact... | Hypoxia‐Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis |
{"1039": 0.3656192123889923, "1041": 0.1401015669107437, "1044": 0.33605360984802246, "1997": 0.010684899985790253, "1998": 0.22548456490039825, "1999": 0.07159364968538284, "2003": 0.15693697333335876, "2004": 0.11865071207284927, "2008": 0.0058422754518687725, "2011": 0.4537591338157654, "2012": 0.11951763927936554, ... | 33036897 | Tyrosol and farnesol are quorum-sensing molecules produced by Candida albicans which accelerate and block, respectively, the morphological transition from yeasts to hyphae. In this study, we have investigated the secretion of tyrosol by C. albicans and explored its likely role in biofilm development. Both planktonic (s... | Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development. |
{"1015": 0.272677481174469, "1017": 0.1889725625514984, "1043": 0.5640701055526733, "1047": 0.5651806592941284, "2004": 0.05046287178993225, "2005": 0.11691460013389587, "2007": 0.0913962796330452, "2011": 0.40351006388664246, "2013": 0.083342544734478, "2015": 0.030771657824516296, "2029": 0.09761575609445572, "2043":... | 33063763 | MAP kinase signaling modules serve to transduce extracellular signals to the nucleus of eukaryotic cells, but little is known about how signals cross the nuclear envelope. Exposure of yeast cells to increases in extracellular osmolarity activates the HOG1 MAP kinase cascade, which is composed of three tiers of protein ... | Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. |
{"1011": 0.1602703034877777, "1017": 0.06977381557226181, "1021": 0.6181373596191406, "1041": 0.5466978549957275, "1042": 1.020087480545044, "1043": 0.20580662786960602, "1047": 0.969535231590271, "1057": 0.6862877607345581, "1059": 0.6823468804359436, "1062": 0.013579257763922215, "2029": 0.1994270235300064, "2075": 0... | 33068577 | F-box and WD repeat domain-containing 7 (FBW7), the substrate-binding subunit of E3 ubiquitin ligase SCFFBW7 (a complex of SKP1, cullin-1 and FBW7), plays important roles in various physiological and pathological processes. Although FBW7 is required for vascular development, its function in the endothelium remains to b... | FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation |
{"1011": 0.1677299439907074, "1018": 0.24018502235412598, "1044": 0.500420093536377, "1054": 0.630689799785614, "2003": 0.05694137513637543, "2011": 0.2470736801624298, "2015": 0.7978238463401794, "2019": 0.6583697199821472, "2029": 0.1970241367816925, "2033": 0.5718178153038025, "2034": 0.23710809648036957, "2044": 0.... | 33076846 | Polyploidization can precede the development of aneuploidy in cancer. Polyploidization in megakaryocytes (Mks), in contrast, is a highly controlled developmental process critical for efficient platelet production via unknown mechanisms. Using primary cells, we demonstrate that the guanine exchange factors GEF-H1 and EC... | Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes. |
{"1006": 0.10203468054533005, "1011": 0.27786844968795776, "1020": 1.0278041362762451, "1037": 0.6902132034301758, "1044": 0.015504186972975731, "1048": 0.45623743534088135, "2004": 0.5209306478500366, "2005": 0.4624064862728119, "2007": 0.40351006388664246, "2011": 0.4067663550376892, "2012": 0.6522845029830933, "2029... | 33118292 | WHAT IS KNOWN AND OBJECTIVE There is a growing body of experimental and clinical evidence for the atherogenic and pro-thrombotic potential of Lipoprotein(a) [Lp(a)], as well as for its causative role in coronary heart disease and stroke. We comment on novel strategies for reducing Lp(a) levels. COMMENT Irrespective of ... | Optimal therapy for reduction of lipoprotein(a). |
{"1041": 0.255429208278656, "1043": 0.08961215615272522, "1051": 0.2184450328350067, "2000": 0.06429435312747955, "2001": 0.4537591338157654, "2005": 0.20022670924663544, "2007": 0.04767346754670143, "2013": 0.1229778528213501, "2020": 0.07159364968538284, "2029": 0.029824240133166313, "2034": 0.6400018334388733, "2038... | 33127778 | Since the concept of early gastric cancer was first described in Japan in 1962, its treatment has evolved from curative surgical resection to endoscopic resection, initially with polypectomy to more recently with endoscopic submucosal dissection. As worldwide experience with these endoscopic techniques evolve and gain ... | Early gastric cancer and dysplasia. |
{"2000": 0.11691460013389587, "2037": 0.255429208278656, "2079": 0.08782484382390976, "2082": 0.31845372915267944, "2092": 0.19220098853111267, "2104": 0.38574060797691345, "2108": 0.17431432008743286, "2111": 0.10203468054533005, "2155": 0.09761575609445572, "2227": 0.30558720231056213, "2241": 0.3864043951034546, "22... | 33135135 | This article reviews and critiques community-based research on the effects of homelessness on children. Homeless children confront serious threats to their ability to succeed and their future well-being. Of particular concern are health problems, hunger, poor nutrition, developmental delays, anxiety, depression, behavi... | The impact of homelessness on children. |
{"2004": 0.0770333781838417, "2052": 0.08244366943836212, "2064": 0.450652539730072, "2065": 0.016465263441205025, "2071": 0.39893341064453125, "2075": 0.15023678541183472, "2121": 0.4624064862728119, "2129": 0.036437395960092545, "2136": 0.15777134895324707, "2162": 0.18167030811309814, "2177": 0.45251765847206116, "2... | 33169058 | The potential benefits of cooperation in microorganisms can be undermined by genetic conflict within social groups, which can take the form of 'cheating'. For cooperation to succeed as an evolutionary strategy, the negative effects of such conflict must somehow be either prevented or mitigated. To generate an interpret... | Strategies of microbial cheater control. |
{"1052": 0.5415972471237183, "1053": 0.3141832649707794, "1999": 0.09938567131757736, "2001": 0.10291612148284912, "2003": 0.4974553883075714, "2004": 0.15777134895324707, "2013": 0.29619070887565613, "2045": 0.3683255612850189, "2053": 0.2763880789279938, "2062": 0.040196798741817474, "2064": 0.04113444685935974, "207... | 33203108 | INTRODUCTION Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for paraquat poison and consumption is often fatal. The usual cause of death is either acute lung injury or multi-organ failure. AIM To evaluate the role of early haemoperfusion as a therapy in paraquat poisoned patie... | Golden Hours in Severe Paraquat Poisoning-The Role of Early Haemoperfusion Therapy. |
{"1003": 0.03831886500120163, "1014": 0.16359257698059082, "1016": 0.0038986403960734606, "1017": 0.045809537172317505, "1039": 0.3910386264324188, "1043": 0.19220098853111267, "1052": 0.3615458607673645, "2001": 0.1751343309879303, "2020": 0.13157635927200317, "2042": 0.28155985474586487, "2043": 0.18978065252304077, ... | 33257464 | CONTEXT Although cerebral palsy (CP) among extremely premature infants has been reported as a major morbidity outcome, there are difficulties comparing published CP rates from many sites over various birth years. OBJECTIVE To assess the changes in population-based, gestational age-specific prevalence rates of CP among ... | Changes in the prevalence of cerebral palsy for children born very prematurely within a population-based program over 30 years. |
{"1052": 0.35677260160446167, "1056": 0.2918238639831543, "1999": 0.020300358533859253, "2002": 0.7267557382583618, "2007": 0.24859806895256042, "2029": 0.034552380442619324, "2050": 0.4462870955467224, "2064": 0.3588210940361023, "2071": 0.030771657824516296, "2089": 0.18573370575904846, "2102": 1.216973900794983, "21... | 33339202 | Porphyria cutanea tarda (PCT) can occur in HIV patients. Current evidence suggests that HIV infection may interfere with the hepatic cytochrome oxidase system, leading to porphyrin metabolism impairment. Moreover, chronic hemodialysis in renal failure may be a risk factor for PCT. In addition to the contributory factor... | Desferrioxamine treatment of porphyria cutanea tarda in a patient with HIV and chronic renal failure. |
{"1011": 0.058784693479537964, "1015": 0.1685553640127182, "1017": 0.2409527748823166, "1038": 0.40806588530540466, "1043": 1.156782865524292, "1047": 0.31204116344451904, "1155": 0.6043586730957031, "2006": 0.5925496220588684, "2007": 0.22782009840011597, "2015": 0.15943801403045654, "2022": 0.2969166338443756, "2026"... | 33387953 | Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined. Here we demonstrate that recurrent mutations in the Gβ proteins GNB1 and GNB2 confer cytokine-independent growth and activate canonical G protein signaling... | Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance |
{"1011": 0.15943801403045654, "1013": 0.2247048318386078, "1039": 0.3170322775840759, "1040": 0.06337817758321762, "1052": 0.08692999184131622, "2005": 0.1889725625514984, "2006": 0.29981520771980286, "2007": 0.07612881064414978, "2011": 0.304147332906723, "2013": 0.25845035910606384, "2015": 0.12642613053321838, "2020... | 33390472 | We have developed a novel panel of cell-surface markers for the isolation and study of all major cell types of the human pancreas. Hybridomas were selected after subtractive immunization of Balb/C mice with intact or dissociated human islets and assessed for cell-type specificity and cell-surface reactivity by immunohi... | Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. |
{"1009": 0.10818854719400406, "1011": 0.1873544454574585, "1039": 0.02316705882549286, "1040": 0.42416930198669434, "1048": 0.5450005531311035, "1052": 0.13670019805431366, "1056": 0.3297532796859741, "1999": 0.014542185701429844, "2005": 0.004870930220931768, "2007": 0.12986256182193756, "2011": 0.2983669638633728, "2... | 33397197 | Modest clinical outcomes of dendritic-cell (DC) vaccine trials call for the refinement of DC vaccine design. Although many potential antigens have been identified, development of methods to enhance antigen presentation by DCs has lagged. We have engineered a potent, drug-inducible CD40 (iCD40) receptor that permits tem... | Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo |
{"1014": 0.35677260160446167, "1020": 0.22704219818115234, "1026": 0.09050461649894714, "1038": 0.7737906575202942, "1042": 0.7827593088150024, "1044": 0.1011524572968483, "1048": 0.32553088665008545, "1050": 0.2501201331615448, "1052": 0.5941681861877441, "2026": 0.32270604372024536, "2029": 0.014542185701429844, "203... | 33409100 | CONTEXT High plasma homocysteine levels are a risk factor for mortality and vascular disease in observational studies of patients with chronic kidney disease. Folic acid and B vitamins decrease homocysteine levels in this population but whether they lower mortality is unknown. OBJECTIVE To determine whether high doses ... | Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial. |
{"1015": 0.004870930220931768, "1016": 0.12986256182193756, "1017": 0.3170322775840759, "1050": 0.05046287178993225, "1056": 0.4158279001712799, "1997": 0.0752234235405922, "1998": 0.26446542143821716, "2000": 0.04394211992621422, "2001": 0.0058422754518687725, "2015": 0.524982750415802, "2028": 0.6739205718040466, "20... | 33417012 | OBJECTIVE This study compared, in treatment and control groups, the phenomena of coaction, which is the probability that taking effective action on one behavior is related to taking effective action on a second behavior. METHODS Pooled data from three randomized trials of Transtheoretical Model (TTM) tailored intervent... | Treated individuals who progress to action or maintenance for one behavior are more likely to make similar progress on another behavior: coaction results of a pooled data analysis of three trials. |
{"1011": 0.18654440343379974, "1014": 0.3824150264263153, "1038": 0.8357921838760376, "1043": 0.20580662786960602, "1050": 0.2622140049934387, "1052": 0.05046287178993225, "1060": 0.5151132941246033, "1081": 0.7800771594047546, "1156": 0.5186077356338501, "2003": 0.22782009840011597, "2019": 0.20501139760017395, "2054"... | 33458992 | CONTEXT Trabecular bone score (TBS) is a novel texture index that evaluates the pixel gray-level variations in lumbar spine dual-energy X-ray absorptiometry images and is related to bone microarchitecture independent of bone mineral density (BMD). OBJECTIVE We investigated lumbar spine TBS as an indicator for skeletal ... | Trabecular bone score as an indicator for skeletal deterioration in diabetes. |
{"1011": 0.5116065740585327, "1017": 0.29109421372413635, "1039": 0.09672962874174118, "1056": 1.1363043785095215, "2007": 0.0354953333735466, "2011": 0.3170322775840759, "2012": 0.3027053773403168, "2029": 0.18492233753204346, "2048": 0.1808556467294693, "2050": 0.2983669638633728, "2075": 0.42608439922332764, "2076":... | 33499189 | T cell receptor (TCR-CD3) triggering involves both receptor clustering and conformational changes at the cytoplasmic tails of the CD3 subunits. The mechanism by which TCRalphabeta ligand binding confers conformational changes to CD3 is unknown. By using well-defined ligands, we showed that induction of the conformation... | Full activation of the T cell receptor requires both clustering and conformational changes at CD3. |
{"1011": 0.1602703034877777, "1017": 0.20022670924663544, "1042": 0.5450005531311035, "1052": 0.25694093108177185, "1058": 0.007782140281051397, "1999": 0.05046287178993225, "2002": 0.5827828645706177, "2015": 0.8332487344741821, "2029": 0.31845372915267944, "2033": 0.8492490649223328, "2036": 0.1685553640127182, "2063... | 33507866 | A critical regulator of autophagy is the Class III PI3K Vps34 (also called PIK3C3). Although Vps34 is known to play an essential role in autophagy in yeast, its role in mammals remains elusive. To elucidate the physiological function of Vps34 and to determine its precise role in autophagy, we have generated Vps34(f/f) ... | Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. |
{"1003": 0.07250232994556427, "1014": 0.2689530849456787, "1040": 0.13243216276168823, "1052": 0.3547199070453644, "1998": 0.05694137513637543, "2007": 0.07884006202220917, "2021": 0.040196798741817474, "2025": 0.11343330889940262, "2053": 0.31845372915267944, "2058": 0.006812678650021553, "2072": 0.3622259199619293, "... | 33533307 | BACKGROUND The Digitalis Investigation Group trial reported that treatment with digoxin did not decrease overall mortality among patients with heart failure and depressed left ventricular systolic function, although it did reduce hospitalizations slightly. Even though the epidemiologic features, causes, and prognosis o... | Sex-based differences in the effect of digoxin for the treatment of heart failure. |
{"1005": 0.13414156436920166, "1009": 0.680370569229126, "1011": 0.27044451236724854, "1018": 0.23092569410800934, "1039": 0.026025565341114998, "1043": 0.6128603219985962, "1054": 0.24631060659885406, "1055": 0.31204116344451904, "1056": 1.0855059623718262, "2005": 0.13157635927200317, "2007": 0.014542185701429844, "2... | 33535222 | CD4+CD25+ regulatory T cells (Treg's) play a pivotal role in preventing organ-specific autoimmune diseases and in inducing tolerance to allogeneic organ transplants. We and others recently demonstrated that high numbers of Treg's can also modulate graft-versus-host disease (GVHD) if administered in conjunction with all... | Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. |
{"1011": 0.1930064558982849, "1015": 0.47463157773017883, "1017": 0.7592713832855225, "1040": 0.6086184978485107, "1999": 0.0009760859538801014, "2007": 0.015504186972975731, "2011": 0.39762192964553833, "2028": 0.12038381397724152, "2029": 0.30558720231056213, "2034": 0.29255300760269165, "2041": 0.41647201776504517, ... | 33535447 | This study evaluates the expression of the chemorepellent semaphorin III (D)/collapsin-1 (sema III) following lesions to the rat CNS. Scar tissue, formed after penetrating injuries to the lateral olfactory tract (LOT), cortex, perforant pathway, and spinal cord, contained numerous spindle-shaped cells expressing high l... | Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS. |
{"1011": 0.06246116757392883, "1014": 0.22157983481884003, "1015": 0.06429435312747955, "1017": 0.1685553640127182, "1997": 0.1913948506116867, "1999": 0.053244512528181076, "2000": 0.18573370575904846, "2006": 0.06703783571720123, "2010": 0.058784693479537964, "2012": 0.02316705882549286, "2026": 0.9936857223510742, "... | 33554389 | Abstract The effect of increased levels of cAMP upon the differentiation of primary cultures of chick myo blasts has been investigated. 0.1 mM But 2 cAMP or 1 mM 3-isobutyl-1-methylxanthine was added to the cultures 24 h after plating and maintained throughout the 70 h period of culture examined. Both reagents were fou... | The relationship of the level of cyclic amp to differentiation in primary cultures of chick muscle cells. |
{"1011": 0.0058422754518687725, "1021": 0.3346569836139679, "1051": 0.26296505331993103, "1054": 0.47463157773017883, "1999": 0.3077431619167328, "2011": 0.04674193635582924, "2012": 0.6989894509315491, "2029": 0.11256109178066254, "2076": 0.0606246218085289, "2079": 0.03360854089260101, "2109": 0.025073638185858727, "... | 33569870 | The physiological role of autophagic flux within the vascular endothelial layer remains poorly understood. Here, we show that in primary endothelial cells, oxidized and native LDL stimulates autophagosome formation. Moreover, by both confocal and electron microscopy, excess native or modified LDL appears to be engulfed... | Intact endothelial autophagy is required to maintain vascular lipid homeostasis. |
{"1011": 0.15860503911972046, "1017": 0.05786345899105072, "1038": 0.25088030099868774, "1043": 0.23092569410800934, "1999": 0.14179791510105133, "2004": 1.2835346460342407, "2011": 0.20660123229026794, "2012": 0.07793712615966797, "2029": 0.07250232994556427, "2051": 0.4248080551624298, "2063": 0.1510767638683319, "20... | 33634749 | OBJECTIVE Genes encoding the circadian transcriptional apparatus exhibit robust oscillatory expression in murine adipose tissues. This study tests the hypothesis that human subcutaneous adipose-derived stem cells (ASCs) provide an in vitro model in which to monitor the activity of the core circadian transcriptional app... | Induction of circadian gene expression in human subcutaneous adipose-derived stem cells. |
{"1023": 0.5500838756561279, "1039": 0.06520967930555344, "1040": 0.10993985831737518, "1059": 1.1822543144226074, "1060": 0.24018502235412598, "2004": 0.21922965347766876, "2005": 0.18004031479358673, "2006": 0.6343214511871338, "2008": 0.052318159490823746, "2011": 0.22392450273036957, "2026": 0.5278670787811279, "20... | 33638477 | Several components of the Wnt signaling cascade have been shown to function either as tumor suppressor proteins or as oncogenes in multiple human cancers, underscoring the relevance of this pathway in oncogenesis and the need for further investigation of Wnt signaling components as potential targets for cancer therapy.... | BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells. |
{"1017": 0.24171993136405945, "1040": 0.07159364968538284, "1052": 0.3353555500507355, "1998": 0.0797421783208847, "2003": 0.25239890813827515, "2064": 0.08871890604496002, "2090": 0.1994270235300064, "2093": 0.7163142561912537, "2094": 1.19888174533844, "2166": 0.11168810725212097, "2170": 0.04953393340110779, "2209":... | 33667484 | Programmed cell death (PCD), referring to apoptosis, autophagy and programmed necrosis, is proposed to be death of a cell in any pathological format, when mediated by an intracellular program. These three forms of PCD may jointly decide the fate of cells of malignant neoplasms; apoptosis and programmed necrosis invaria... | Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. |
{"1011": 0.18492233753204346, "1055": 0.9052929878234863, "1999": 0.43875885009765625, "2003": 0.10731173306703568, "2011": 0.09050461649894714, "2015": 0.040196798741817474, "2035": 0.3374483287334442, "2048": 0.36290550231933594, "2054": 0.1510767638683319, "2075": 0.6186635494232178, "2090": 0.04207121208310127, "20... | 33669399 | Gametophytic self-incompatibility (SI) in plants is a widespread mechanism preventing self-fertilization and the ensuing inbreeding depression, but it often evolves to self-compatibility. We analyze genetic mechanisms for the breakdown of gametophytic SI, incorporating a dynamic model for the evolution of inbreeding de... | Loss of gametophytic self-incompatibility with evolution of inbreeding depression. |
{"1011": 0.5324648022651672, "1019": 0.29109421372413635, "1049": 0.14179791510105133, "1999": 0.14686977863311768, "2002": 0.09850110858678818, "2004": 0.18248429894447327, "2006": 0.16607704758644104, "2015": 0.5947071313858032, "2026": 0.5696102976799011, "2029": 0.2447827309370041, "2039": 0.5104349255561829, "2058... | 33677323 | MicroRNAs are frequently deregulated in cancer. Here we show that miR-22 is upregulated in myelodysplastic syndrome (MDS) and leukemia and its aberrant expression correlates with poor survival. To explore its role in hematopoietic stem cell function and malignancy, we generated transgenic mice conditionally expressing ... | The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation. |
{"1020": 0.3318578004837036, "1039": 0.40351006388664246, "1041": 0.1619328260421753, "1050": 0.6118015646934509, "1056": 0.9240728616714478, "1998": 0.011650617234408855, "2004": 0.2089812457561493, "2007": 0.13157635927200317, "2011": 0.010684899985790253, "2012": 0.755608320236206, "2020": 0.013579257763922215, "202... | 33684572 | Recent studies indicate both clinical and mechanistic links between atherosclerotic heart disease and intestinal microbial metabolism of certain dietary nutrients producing trimethylamine N-oxide (TMAO). Here we test the hypothesis that gut microbial transplantation can transmit choline diet-induced TMAO production and... | Transmission of atherosclerosis susceptibility with gut microbial transplantation. |
{"1011": 0.33675122261047363, "1041": 0.04207121208310127, "1050": 0.05786345899105072, "1062": 0.45251765847206116, "1996": 0.11604541540145874, "1997": 0.014542185701429844, "1999": 0.16276304423809052, "2003": 0.26446542143821716, "2008": 0.08782484382390976, "2011": 0.22859740257263184, "2013": 0.13157635927200317,... | 33720691 | AWN is a boar protein which originates in secretions of the male accessory glands and which becomes sperm surface-associated upon ejaculation. It is one of the components thought to mediate sperm adhesion to the egg's zona pellucida through a carbohydrate-recognition mechanism. AWN may, thus, participate in the initial... | The complete primary structure of the spermadhesin AWN, a zona pellucida-binding protein isolated from boar spermatozoa. |
{"1038": 0.672426164150238, "1044": 0.4400174915790558, "2002": 1.034767985343933, "2010": 0.07341018319129944, "2011": 0.25239890813827515, "2032": 0.10291612148284912, "2047": 0.5751199722290039, "2073": 0.3381449282169342, "2083": 0.2576959431171417, "2109": 0.5415972471237183, "2129": 0.02887592278420925, "2173": 0... | 33723822 | This paper proposes a framework for examining the process by which government consideration and adoption of new vaccines takes place, with specific reference to developing country settings. The cases of early Hepatitis B vaccine adoption in Taiwan and Thailand are used to explore the relevance of explanatory factors id... | What influences government adoption of vaccines in developing countries? A policy process analysis. |
{"1060": 0.006812678650021553, "1062": 0.3409265875816345, "1999": 0.5133614540100098, "2001": 0.10291612148284912, "2015": 0.08871890604496002, "2020": 0.08513788133859634, "2039": 0.05417001247406006, "2042": 0.3034266233444214, "2043": 0.037378571927547455, "2058": 0.27564704418182373, "2080": 0.11168810725212097, "... | 33733520 | BACKGROUND Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD A nested case-control study... | Benzodiazepines and injurious falls in community dwelling elders. |
{"1020": 0.41389304399490356, "1038": 0.46853771805763245, "1042": 0.4481603503227234, "1052": 0.0009760859538801014, "1998": 0.0317181795835495, "2004": 0.12728634476661682, "2005": 0.15526613593101501, "2034": 0.23787821829319, "2043": 0.2145126610994339, "2050": 0.8813109993934631, "2058": 0.27712854743003845, "2076... | 33740844 | Current understanding of biologic processes indicates that women's nutritional status before and during early pregnancy may play an important role in determining early developmental processes and ensuring successful pregnancy outcomes. We conducted a systematic review of the evidence for the impact of maternal nutritio... | Effect of women's nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. |
{"1017": 0.2749055027961731, "1043": 0.7845434546470642, "1047": 0.10555581003427505, "2011": 0.2976420819759369, "2025": 0.06337817758321762, "2029": 0.24171993136405945, "2033": 0.5968599319458008, "2046": 0.11343330889940262, "2050": 0.45437926054000854, "2075": 0.7067264318466187, "2079": 0.2674594223499298, "2100"... | 33792330 | Hedgehog signaling plays an essential role in patterning of the vertebrate skeleton. Here we demonstrate that conditional inactivation of the Kif3a subunit of the kinesin-2 intraflagellar transport motor in mesenchymal skeletal progenitor cells results in severe patterning defects in the craniofacial area, the formatio... | Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. |
{"1015": 0.9915141463279724, "1042": 0.3547199070453644, "1045": 0.22937409579753876, "1050": 1.2432310581207275, "2003": 0.2539152204990387, "2028": 0.6054253578186035, "2046": 0.11951763927936554, "2053": 0.12986256182193756, "2063": 0.820433497428894, "2087": 0.14179791510105133, "2179": 0.0019512200960889459, "2313... | 33796570 | Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder that affects growth properties of neural-crest-derived cell populations. In addition, approximately one-half of NF1 patients exhibit learning disabilities. To characterize NF1 function both in vitro and in vivo, we circumvent the embryonic lethality of NF1 ... | Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. |
{"1040": 0.4311734735965729, "1051": 0.2689530849456787, "1052": 0.24325250089168549, "1998": 0.015504186972975731, "1999": 0.10993985831737518, "2002": 0.12814582884311676, "2003": 0.04207121208310127, "2004": 0.22937409579753876, "2007": 0.2719337046146393, "2010": 0.684319257736206, "2011": 0.2711893916130066, "2013... | 33835579 | Tuberculosis remains one of the world's leading infectious causes of death. Approximately 80% of all disease is due to postprimary (secondary) tuberculosis in the lung. Unfortunately, tissues of developing lesions are seldom available and there are no recognized models of postprimary tuberculosis. In the preantibiotic ... | Pathology of postprimary tuberculosis in humans and mice: contradiction of long-held beliefs. |
{"1014": 0.38174858689308167, "1038": 0.7153595685958862, "1052": 0.5162794589996338, "2000": 0.07612881064414978, "2001": 0.12038381397724152, "2005": 0.14602625370025635, "2006": 0.09672962874174118, "2020": 0.24631060659885406, "2073": 0.24171993136405945, "2076": 0.42096930742263794, "2104": 0.3339579105377197, "21... | 33872649 | CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facilities in the US Capitol's vicinity. OBJECTIVE To provide information about the nature and extent of indoor secondary ... | Secondary aerosolization of viable Bacillus anthracis spores in a contaminated US Senate Office. |
{"1011": 0.0913962796330452, "1015": 0.38905516266822815, "1043": 0.17267228662967682, "1051": 0.1510767638683319, "1055": 0.7592713832855225, "1999": 0.7009293437004089, "2005": 0.1332872211933136, "2011": 0.22704219818115234, "2028": 0.0317181795835495, "2029": 0.09406650811433792, "2038": 0.12728634476661682, "2044"... | 33884866 | OBJECTIVE The sphingosine-1-phosphate (S1P) receptor agonist fingolimod (FTY720), that has shown efficacy in advanced multiple sclerosis clinical trials, decreases reperfusion injury in heart, liver, and kidney. We therefore tested the therapeutic effects of fingolimod in several rodent models of focal cerebral ischemi... | Fingolimod provides long-term protection in rodent models of cerebral ischemia. |
{"2000": 0.053244512528181076, "2003": 0.05694137513637543, "2038": 0.2231435477733612, "2042": 0.034552380442619324, "2045": 0.06429435312747955, "2047": 0.6744182109832764, "2064": 0.36697331070899963, "2067": 0.3034266233444214, "2071": 0.1889725625514984, "2075": 0.012615402229130268, "2079": 0.14518201351165771, "... | 33904473 | Regeneration of cardiac tissue has the potential to transform cardiovascular medicine. Recent advances in stem cell biology and direct reprogramming, or transdifferentiation, have produced powerful new tools to advance this goal. In this Review we examine key developments in the generation of new cardiomyocytes in vitr... | Induced regeneration—the progress and promise of direct reprogramming for heart repair |
{"1039": 0.255429208278656, "1043": 0.28890204429626465, "1045": 0.5607312321662903, "1999": 0.2105647772550583, "2000": 0.040196798741817474, "2007": 0.2576959431171417, "2011": 0.06977381557226181, "2012": 0.13755162060260773, "2020": 0.02792670577764511, "2029": 0.11778303235769272, "2050": 1.1431772708892822, "2076... | 33904789 | Measurements of carcinoembryonic antigen (CEA) in blood increased dramatically in some patients who were receiving injections of monoclonal antibody. CEA titers were measured with a monoclonal antibody-based double-determinant enzyme immunoassay in which untreated plasma specimens were diluted with an equal volume of b... | "Sandwich"-type immunoassay of carcinoembryonic antigen in patients receiving murine monoclonal antibodies for diagnosis and therapy. |
{"1016": 0.05970508232712746, "1018": 0.4437839686870575, "1040": 0.7229714393615723, "2012": 0.058784693479537964, "2025": 0.053244512528181076, "2064": 0.18167030811309814, "2094": 0.29036402702331543, "2139": 0.5174443125724792, "2176": 0.20739519596099854, "2265": 0.07612881064414978, "2309": 0.4580921530723572, "2... | 33911859 | Impaired axonal transport in motor neurons has been proposed as a mechanism for neuronal degeneration in motor neuron disease. Here we show linkage of a lower motor neuron disease to a region of 4 Mb at chromosome 2p13. Mutation analysis of a gene in this interval that encodes the largest subunit of the axonal transpor... | Mutant dynactin in motor neuron disease |
{"1011": 0.35334911942481995, "1017": 0.5517725944519043, "1044": 0.450652539730072, "1999": 0.03831886500120163, "2003": 0.27934664487838745, "2005": 0.007782140281051397, "2008": 0.10906458646059036, "2011": 0.3683255612850189, "2029": 0.3134697377681732, "2050": 0.9857001900672913, "2061": 0.19782574474811554, "2076... | 33912020 | Semaphorin3A (Sema3A) is a repulsive guidance molecule for axons, which acts by inducing growth cone collapse through phosphorylation of CRMP2 (collapsin response mediator protein 2). Here, we show a role for CRMP2 oxidation and thioredoxin (TRX) in the regulation of CRMP2 phosphorylation and growth cone collapse. Sema... | Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse. |
{"1011": 0.35813871026039124, "1017": 0.7934166193008423, "1020": 0.5778634548187256, "1050": 0.8366385698318481, "1051": 0.8973627090454102, "1052": 0.28670501708984375, "1999": 0.052318159490823746, "2005": 0.2026219218969345, "2007": 0.417115718126297, "2011": 0.176772341132164, "2029": 0.036437395960092545, "2044":... | 33912748 | OBJECTIVE To determine if n-3 polyunsaturated fatty acid (PUFA) supplementation (versus treatment with n-6 polyunsaturated or other fatty acid supplements) affects the metabolism of osteoarthritic (OA) cartilage. METHODS The metabolic profile of human OA cartilage was determined at the time of harvest and after 24-hour... | Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids. |
{"1014": 0.006812678650021553, "1043": 0.34508460760116577, "1044": 0.5990082025527954, "1052": 0.39367714524269104, "1055": 0.3012613356113434, "1997": 1.495358943939209, "2003": 0.35950297117233276, "2005": 0.15023678541183472, "2008": 0.05970508232712746, "2011": 0.05417001247406006, "2015": 1.2129170894622803, "202... | 33918970 | OBJECTIVE Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet-induced obese (DIO) and diet-resistant (DR) rats. ME... | Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet-induced obese rats. |
{"1011": 0.5461324453353882, "1015": 0.7201237678527832, "1039": 0.09584271162748337, "1041": 0.34508460760116577, "1048": 0.6181373596191406, "1054": 0.7144040465354919, "1997": 0.15860503911972046, "1999": 0.030771657824516296, "2005": 0.10555581003427505, "2006": 0.3547199070453644, "2007": 0.29328158497810364, "201... | 33920995 | No direct evidence has been reported whether the spatial organization of ICAM-1 on the cell surface is linked to its physiological function in terms of leukocyte adhesion and transendothelial migration (TEM). Here we observed that ICAM-1 by itself directly regulates the de novo elongation of microvilli and is thereby c... | RKIKK motif in the intracellular domain is critical for spatial and dynamic organization of ICAM-1: functional implication for the leukocyte adhesion and transmigration. |
{"2001": 0.43244171142578125, "2005": 0.10555581003427505, "2015": 0.18167030811309814, "2020": 0.006812678650021553, "2034": 0.6598852276802063, "2035": 0.026976587250828743, "2038": 0.1212492436170578, "2041": 0.043007105588912964, "2042": 0.29255300760269165, "2043": 0.3262358605861664, "2045": 0.19220098853111267, ... | 33934971 | The first experimental vaccination against ticks was carried out 60 years ago. Since then, progress has been slow, although the recent commercial release of a recombinant vaccine against Boophilus microplus is significant. The nature of naturally acquired protective immunity against ticks is poorly understood, particul... | Immunology of the tick-host interaction and the control of ticks and tick-borne diseases. |
{"1040": 0.3012613356113434, "1997": 0.06703783571720123, "1999": 0.16442140936851501, "2000": 0.3019835948944092, "2002": 0.8707374930381775, "2005": 0.24171993136405945, "2007": 0.22157983481884003, "2011": 0.31132611632347107, "2012": 0.20022670924663544, "2013": 0.6553317308425903, "2015": 0.11778303235769272, "202... | 33955641 | Procedures are described for the isolation of lipoproteins from human serum by precipitation with polyanions and divalent cations. A mixture of low and very low density lipoproteins can be prepared without ultracentrifugation by precipitation with heparin and either MnCl(2) alone or MgCl(2) plus sucrose. In both cases ... | Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. |
{"1015": 0.5033760666847229, "1016": 0.7482418417930603, "1043": 0.8885661959648132, "1044": 0.7764897346496582, "1045": 0.5370414853096008, "2001": 0.03360854089260101, "2002": 0.10555581003427505, "2004": 0.0770333781838417, "2005": 0.3339579105377197, "2007": 0.2247048318386078, "2028": 0.2741633653640747, "2038": 0... | 33960383 | Abstract Evidence obtained in the 1990's strongly supports the notion that glycaemic control is important not only in Type I (insulin-dependent), but also in Type II (non-insulin-dependent) diabetes mellitus. Although measurement of HbA1c is the standard for assessing the effect of glucose control in the occurrence and... | The role of oral antidiabetic agents: why and when to use an early-phase insulin secretion agent in Type II diabetes mellitus |
{"1011": 0.09850110858678818, "1016": 0.016465263441205025, "1059": 0.39893341064453125, "1999": 0.014542185701429844, "2006": 0.10291612148284912, "2011": 0.056018441915512085, "2013": 0.04674193635582924, "2015": 0.12986256182193756, "2029": 0.025073638185858727, "2033": 0.7426811456680298, "2041": 0.2689530849456787... | 33986200 | Probing a wide range of cellular phenotypes in neurodevelopmental disorders using patient-derived neural progenitor cells (NPCs) can be facilitated by 3D assays, as 2D systems cannot entirely recapitulate the arrangement of cells in the brain. Here, we developed a previously unidentified 3D migration and differentiatio... | Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. |
{"1016": 0.34370049834251404, "1996": 0.004870930220931768, "2005": 0.036437395960092545, "2008": 0.0317181795835495, "2029": 0.30486753582954407, "2043": 0.17759032547473907, "2064": 0.15777134895324707, "2070": 0.0606246218085289, "2075": 0.11430477350950241, "2076": 0.7144040465354919, "2079": 0.06246116757392883, "... | 33986507 | The rapid activation of gene expression in response to stimuli occurs largely through the regulation of RNA polymerase II-dependent transcription. In this Review, we discuss events that occur during the transcription cycle in eukaryotes that are important for the rapid and specific activation of gene expression in resp... | Inducible gene expression: diverse regulatory mechanisms |
{"1011": 0.2822965085506439, "1047": 0.10203468054533005, "1996": 0.04674193635582924, "2007": 0.021256839856505394, "2012": 0.42096930742263794, "2015": 0.08513788133859634, "2029": 0.3923587501049042, "2043": 0.176772341132164, "2064": 0.02412080205976963, "2072": 0.3526630103588104, "2073": 0.11691460013389587, "207... | 33989422 | Comment on: Chan KL, Palmai-Pallag T, Ying S, Hickson ID. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol 2009; 11:753-60. | On the origins of ultra-fine anaphase bridges. |
{"1017": 0.19862671196460724, "1022": 0.10731173306703568, "1041": 0.5232481360435486, "1047": 0.32199856638908386, "1048": 0.06429435312747955, "1056": 1.0172666311264038, "1062": 0.8091925978660583, "2003": 0.04207121208310127, "2005": 0.11343330889940262, "2011": 0.2516399025917053, "2012": 0.3170322775840759, "2014... | 34016944 | PURPOSE Tyrosine kinase (TK) inhibitors are emerging as a promising new approach to the treatment of HER overexpressing tumors, however optimal use of these agents awaits further definition of the downstream signaling pathways that mediate their effects. We reported previously that both EGFR- and Her2-overexpressing tu... | Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling. |
{"1013": 0.045809537172317505, "1019": 0.1401015669107437, "1044": 0.1602703034877777, "2002": 0.022212404757738113, "2005": 0.1332872211933136, "2011": 0.2667117714881897, "2012": 0.08244366943836212, "2024": 0.0606246218085289, "2029": 0.1510767638683319, "2039": 0.4337083101272583, "2043": 0.04487626627087593, "2044... | 34016987 | Monocytes are primary targets for human CMV (HCMV) infection and are proposed to be responsible for hematogenous dissemination of the virus. Monocytes acquire different functional traits during polarization to the classical proinflammatory M1 macrophage or the alternative antiinflammatory M2 macrophage. We hypothesized... | Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage. |
{"1011": 0.17020416259765625, "1013": 0.22782009840011597, "1014": 0.5860490798950195, "1015": 0.9248477816581726, "1016": 0.06337817758321762, "1019": 0.21687394380569458, "1020": 0.32129061222076416, "1039": 0.7172679901123047, "1043": 0.5438674688339233, "1045": 0.2659635543823242, "1052": 0.29619070887565613, "1056... | 34025053 | BACKGROUND Type 1 diabetes results from T-cell-mediated destruction of β cells. Findings from preclinical studies and pilot clinical trials suggest that antithymocyte globulin (ATG) might be effective for reducing this autoimmune response. We assessed the safety and efficacy of rabbit ATG in preserving islet function i... | Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial. |
{"1011": 0.13925230503082275, "1996": 0.4752389192581177, "1997": 0.2719337046146393, "1999": 0.21687394380569458, "2001": 0.3127557039260864, "2002": 0.7701805830001831, "2010": 0.9271688461303711, "2015": 0.2749055027961731, "2024": 0.22079704701900482, "2029": 0.20977331697940826, "2031": 0.12986256182193756, "2034"... | 34034749 | Ever since the discovery of the nucleosome in 1974, scientists have stumbled upon discrete particles in which DNA is wrapped around histone complexes of different stoichiometries: octasomes, hexasomes, tetrasomes, "split" half-nucleosomes, and, recently, bona fide hemisomes. Do all these particles exist in vivo? Under ... | The nucleosome family: dynamic and growing. |
{"1014": 0.2501201331615448, "1038": 0.3127557039260864, "1039": 0.2231435477733612, "1044": 0.13925230503082275, "1052": 0.46363574266433716, "1998": 0.0797421783208847, "1999": 0.40285754203796387, "2005": 0.08871890604496002, "2007": 0.3656192123889923, "2011": 0.021256839856505394, "2026": 0.6950984001159668, "2029... | 34054472 | BACKGROUND Accumulating evidence has indicated that corin plays critical roles in regulating salt-water balance, blood pressure and cardiac function by activating natriuretic peptides. The present case-control study was designed to evaluate the association of serum soluble corin with acute myocardial infarction (AMI). ... | Association between serum corin levels and risk of acute myocardial infarction. |
{"1054": 0.20022670924663544, "1998": 0.2719337046146393, "2007": 0.03831886500120163, "2014": 0.25694093108177185, "2029": 0.08871890604496002, "2038": 0.1221139207482338, "2064": 0.1485546976327896, "2071": 0.38041436672210693, "2079": 0.09317722171545029, "2080": 0.09228714555501938, "2090": 0.47463157773017883, "20... | 34066665 | Breast cancer evolution and tumor progression are governed by the complex interactions between steroid receptor [estrogen receptor (ER) and progesterone receptor] and growth factor receptor signaling. In recent years, the field of cancer therapy has witnessed the emergence of multiple strategies targeting these specifi... | Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. |
{"1011": 0.15275461971759796, "1052": 0.1510767638683319, "1055": 0.1946154683828354, "2007": 0.35128939151763916, "2011": 0.28597161173820496, "2012": 0.12642613053321838, "2026": 0.5080875158309937, "2029": 0.1602703034877777, "2038": 0.004870930220931768, "2078": 0.06429435312747955, "2104": 0.255429208278656, "2140... | 34071621 | Vascular disease progression is associated with marked changes in vascular smooth muscle cell (SMC) phenotype and function. SMC contractile gene expression and, thus differentiation, is under direct transcriptional control by the transcription factor, serum response factor (SRF); however, the mechanisms dynamically reg... | Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation |
{"1048": 0.2223619967699051, "1058": 0.07341018319129944, "1157": 0.0009760859538801014, "1999": 0.016465263441205025, "2000": 0.013579257763922215, "2003": 0.037378571927547455, "2006": 0.04674193635582924, "2007": 0.0009760859538801014, "2011": 0.07431721687316895, "2013": 0.38308101892471313, "2014": 0.5444341897964... | 34074902 | Abstract Feline leukemia virus (FeLV), Gammaretrovirus, and feline immunodeficiency virus, a Lentivirus, are members of the family Retroviridae, and may establish persistent infections in the domestic cat (Felis catus). Cytoproliferative and cytosuppressive disorders may result from infection with these viruses. Morbid... | SEROSURVEY FOR FELINE LEUKEMIA VIRUS AND LENTIVIRUSES IN CAPTIVE SMALL NEOTROPIC FELIDS IN SÃO PAULO STATE, BRAZIL |
{"1017": 0.3416208028793335, "1039": 0.17840765416622162, "1043": 0.4926934838294983, "1045": 0.3070250153541565, "1053": 0.9628462791442871, "1055": 0.2478361576795578, "1997": 0.11168810725212097, "1999": 0.3923587501049042, "2011": 0.25239890813827515, "2029": 0.2969166338443756, "2034": 0.10555581003427505, "2035":... | 34101101 | Several species of rodents are used to investigate the metabolism of quercetin in vivo. However, it is unclear whether they are a proper animal model. Thus, we compared the metabolism of quercetin in Wistar rats (rats), Balb/c mice (mice) and Mongolian gerbils (gerbils). We determined the levels of quercetin metabolite... | Comparing the metabolism of quercetin in rats, mice and gerbils |
{"1011": 0.1808556467294693, "1052": 0.6249561905860901, "1056": 0.021256839856505394, "2011": 0.08244366943836212, "2015": 0.06977381557226181, "2019": 0.5290185213088989, "2029": 0.20739519596099854, "2046": 0.06703783571720123, "2058": 0.7276995778083801, "2098": 0.12384103983640671, "2100": 0.5579402446746826, "210... | 34103335 | A long-standing hypothesis on tumorigenesis is that cell division failure, generating genetically unstable tetraploid cells, facilitates the development of aneuploid malignancies. Here we test this idea by transiently blocking cytokinesis in p53-null (p53-/-) mouse mammary epithelial cells (MMECs), enabling the isolati... | Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells |
{"1011": 0.16110190749168396, "1037": 0.02412080205976963, "1054": 0.817850649356842, "1055": 0.823009729385376, "1060": 0.5860490798950195, "1996": 0.006812678650021553, "1997": 0.029824240133166313, "1999": 0.1710275560617447, "2003": 0.012615402229130268, "2005": 0.31845372915267944, "2006": 0.02792670577764511, "20... | 34105878 | Claspin is required for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing incompletely replicated DNA. We show here that Claspin associates with chromatin in a regulated manner during S phase. Binding of Claspin to chromatin depends on the pre-replication complex (pre-RC) and Cdc45 but not on repl... | Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. |
{"1014": 0.5415972471237183, "1016": 0.06337817758321762, "1017": 0.1358480453491211, "1019": 0.3949938118457794, "1039": 0.7629209756851196, "2020": 0.0770333781838417, "2034": 0.02412080205976963, "2055": 0.015504186972975731, "2062": 0.18816383183002472, "2084": 0.12814582884311676, "2086": 0.20580662786960602, "211... | 34121231 | INTRODUCTION Cold-related respiratory symptoms are common among northern populations, especially among people suffering from respiratory diseases. However, the prevalence of such symptoms in the general population and the threshold temperatures at which the symptoms start to emerge are poorly known. OBJECTIVES The pres... | Cold-related respiratory symptoms in the general population. |
{"1014": 0.01934296265244484, "1052": 0.13499516248703003, "1156": 0.12384103983640671, "2007": 0.11081436276435852, "2084": 0.007782140281051397, "2090": 0.41195443272590637, "2116": 0.07250232994556427, "2121": 0.26146242022514343, "2140": 0.5718178153038025, "2146": 0.21135559678077698, "2152": 0.3903779089450836, "... | 34139429 | CONTEXT Although beta-blockers improve symptoms and survival in adults with heart failure, little is known about these medications in children and adolescents. OBJECTIVE To prospectively evaluate the effects of carvedilol in children and adolescents with symptomatic systemic ventricular systolic dysfunction. DESIGN, SE... | Carvedilol for children and adolescents with heart failure: a randomized controlled trial. |
{"1011": 0.16359257698059082, "1015": 0.10993985831737518, "1019": 0.18004031479358673, "1038": 0.8400169610977173, "1049": 0.46363574266433716, "1052": 0.3723714053630829, "2003": 0.25694093108177185, "2004": 0.23402166366577148, "2013": 0.3248254358768463, "2026": 0.03925827145576477, "2029": 0.0029254043474793434, "... | 34189936 | Malignant pleural mesothelioma (MPM) is a highly aggressive neoplasm arising from the mesothelial cells lining the parietal pleura and it exhibits poor prognosis. Although there has been significant progress in MPM treatment, development of more efficient therapeutic approaches is needed. BMAL1 is a core component of t... | The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma. |
{"1011": 0.5629584193229675, "1013": 0.006812678650021553, "1040": 1.180456280708313, "1057": 0.417115718126297, "1060": 0.3547199070453644, "1998": 0.07159364968538284, "2003": 0.19862671196460724, "2008": 0.034552380442619324, "2011": 0.1905880719423294, "2015": 0.6471850275993347, "2024": 0.2741633653640747, "2076":... | 34198365 | Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription. Little was known about DPC-specific repair mechanisms until the recent identification of a DPC-processing protease in yeast. The existence of a DPC protease in higher... | Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN |
{"1043": 0.27934664487838745, "1999": 0.6170841455459595, "2004": 0.12038381397724152, "2009": 0.05786345899105072, "2013": 0.06154331564903259, "2025": 0.0029254043474793434, "2037": 0.022212404757738113, "2038": 0.034552380442619324, "2073": 0.28963330388069153, "2079": 0.26446542143821716, "2084": 0.1889725625514984... | 34198460 | BACKGROUND Given the high value placed on children in sub-Saharan Africa, previous research suggests that infertility increases the risk of psychological distress and marital conflict, encourages risky sexual behavior and deprives infertile individuals and couples of an important source of economic and social capital. ... | 'Zero is not good for me': implications of infertility in Ghana. |
{"1011": 0.026976587250828743, "1038": 0.13925230503082275, "1050": 0.04113444685935974, "2000": 0.04953393340110779, "2001": 0.10993985831737518, "2004": 0.056018441915512085, "2007": 0.2822965085506439, "2012": 0.026025565341114998, "2020": 0.15526613593101501, "2034": 0.23787821829319, "2044": 0.1221139207482338, "2... | 34208005 | OBJECTIVES The original objective was to determine whether the use of bilevel positive airway pressure (BiPAP) ventilation would reduce the need for endotracheal intubation, the length of hospital stay, and hospital charges in patients with status asthmaticus. The development of physician treatment bias made patient en... | Ethical dilemmas in a randomized trial of asthma treatment: can Bayesian statistical analysis explain the results? |
{"1998": 0.16607704758644104, "1999": 0.0058422754518687725, "2007": 0.0913962796330452, "2015": 0.16110190749168396, "2062": 0.15442965924739838, "2076": 0.23710809648036957, "2077": 0.1946154683828354, "2084": 0.2763880789279938, "2087": 0.13414156436920166, "2088": 0.07884006202220917, "2094": 0.4914994537830353, "2... | 34227917 | OBJECTIVE To review the literature on mental health and psychiatric morbidity in prison populations and relate findings to a Danish study on remand prisoners. METHOD The literature is reviewed and subdivided in the following section: validity of psychometrics in prison populations, prevalence of psychiatric disorders p... | Mental health in prison populations. A review--with special emphasis on a study of Danish prisoners on remand. |
{"1043": 0.2105647772550583, "2005": 0.0058422754518687725, "2013": 0.058784693479537964, "2015": 0.5080875158309937, "2029": 0.12814582884311676, "2037": 0.27044451236724854, "2057": 0.11517547070980072, "2058": 0.15023678541183472, "2062": 0.37907835841178894, "2064": 0.2018241584300995, "2079": 0.4318077862262726, "... | 34228604 | Females live longer than males in many species, including humans. We have traced a possible explanation for this phenomenon to the beneficial action of estrogens, which bind to estrogen receptors and increase the expression of longevity-associated genes, including those encoding the antioxidant enzymes superoxide dismu... | Why females live longer than males: control of longevity by sex hormones. |
{"1011": 0.41065993905067444, "1038": 0.8658194541931152, "1045": 0.8509185314178467, "1048": 0.36426326632499695, "1056": 0.6043586730957031, "1996": 0.12814582884311676, "1998": 0.09761575609445572, "1999": 0.02792670577764511, "2029": 0.19862671196460724, "2034": 0.0913962796330452, "2035": 0.4914994537830353, "2076... | 34254203 | In this Opinion article, I address the role of the pre-B-cell receptor (pre-BCR) in the development of antigen-specific B cells in terms of immunoglobulin heavy chain (IgH) variable-region repertoire selection, precursor B-cell differentiation and proliferation, and IgH allelic exclusion. Comparisons with the role of t... | The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire |
{"1041": 0.1994270235300064, "1044": 1.0172666311264038, "1048": 0.02316705882549286, "2002": 1.2284748554229736, "2003": 0.567397952079773, "2007": 0.030771657824516296, "2010": 0.22859740257263184, "2054": 0.18654440343379974, "2072": 0.3930181860923767, "2087": 0.1889725625514984, "2121": 0.40285754203796387, "2140"... | 34258065 | Helicobacter infection is a chronic persistent condition which is responsible for the majority of cases of gastric and duodenal ulcers, and gastric cancer. The study of the bacteria, the interaction of the bacteria with the host, and the host immune response has greatly benefited from standardization of culture techniq... | Helicobacter species methods and protocols. Introduction. |
{"1009": 0.6659244894981384, "1014": 0.2659635543823242, "1017": 0.11430477350950241, "1023": 0.14602625370025635, "1038": 0.6583697199821472, "1040": 0.2667117714881897, "1041": 0.1011524572968483, "1052": 0.34922540187835693, "1999": 0.4462870955467224, "2006": 0.006812678650021553, "2007": 0.026976587250828743, "201... | 34268160 | BACKGROUND Drug-eluting stent (DES) implantation is routine during coronary revascularization because DES significantly reduce rates of restenosis and target lesion revascularization compared with bare metal stent (BMS). However, available DES have limitations, such as late thrombosis because of delayed healing with po... | Effectiveness of statin-eluting stent on early inflammatory response and neointimal thickness in a porcine coronary model. |
{"1014": 0.2231435477733612, "1041": 0.04487626627087593, "1050": 0.053244512528181076, "1059": 1.0030416250228882, "1999": 0.09406650811433792, "2001": 0.1332872211933136, "2013": 0.5116065740585327, "2020": 0.3339579105377197, "2029": 0.06795065850019455, "2048": 0.09850110858678818, "2062": 0.43623676896095276, "207... | 34287602 | Intrahost genetic diversity was analysed in naturally infected mosquitoes and birds to determine whether West Nile virus (WNV) exists in nature as a quasispecies and to quantify selective pressures within and between hosts. WNV was sampled from ten infected birds and ten infected mosquito pools collected on Long Island... | Genetic variation in West Nile virus from naturally infected mosquitoes and birds suggests quasispecies structure and strong purifying selection. |
{"1011": 0.010684899985790253, "1016": 0.1693800985813141, "1043": 0.20739519596099854, "1044": 0.861702561378479, "1045": 0.9500881433486938, "1052": 0.4425300657749176, "1996": 0.06154331564903259, "1998": 0.3870677351951599, "2002": 0.06429435312747955, "2007": 0.0770333781838417, "2019": 0.47036975622177124, "2021"... | 34316341 | The spatial patterns of IGF2 and H19 gene expression are strikingly similar during parts of human embryonic/fetal and early postnatal development. Notable exceptions were found with the ciliary anlage of the embryonic retina and the choroid plexus/leptomeninges, where transcripts from the IGF2 but not the H19 locus cou... | Overlapping patterns of IGF2 and H19 expression during human development: biallelic IGF2 expression correlates with a lack of H19 expression. |
{"1038": 0.5562619566917419, "1042": 0.38308101892471313, "1043": 0.3134697377681732, "1999": 0.15693697333335876, "2005": 0.09050461649894714, "2006": 0.15359249711036682, "2012": 0.02792670577764511, "2025": 0.2800849378108978, "2029": 0.23864774405956268, "2043": 0.1221139207482338, "2044": 0.7352184057235718, "2051... | 34328964 | The localization and synthesis of basic fibroblast growth factor (bFGF) in the rat carotid artery were investigated at times of chronic smooth muscle cell proliferation. Immunocytochemical staining showed the presence of bFGF in the uninjured arterial wall, and after balloon injury, this cellular staining was decreased... | Intimal smooth muscle cell proliferation after balloon catheter injury. The role of basic fibroblast growth factor. |
{"1014": 0.15526613593101501, "1039": 0.535327672958374, "1047": 0.822151780128479, "1058": 0.3923587501049042, "1999": 0.319873183965683, "2002": 0.8100618124008179, "2004": 0.4400174915790558, "2005": 0.4203280806541443, "2007": 0.4311734735965729, "2029": 0.009718249551951885, "2035": 0.21135559678077698, "2102": 0.... | 34338075 | PURPOSE Anticoagulant prophylaxis in patients with central venous catheters is controversial. We performed a meta-analysis of randomized controlled trials of anticoagulant prophylaxis in patients with central venous catheters. METHODS MEDLINE and EMBASE were searched up to May 2006, supplemented by manual searches of c... | Prevention of central venous catheter-associated thrombosis: a meta-analysis. |
{"1003": 0.02792670577764511, "1020": 0.3241194784641266, "1021": 0.16359257698059082, "1022": 0.47036975622177124, "1041": 0.09050461649894714, "1050": 0.08244366943836212, "1056": 0.7163142561912537, "1081": 0.4831010699272156, "2005": 0.20660123229026794, "2007": 0.06703783571720123, "2012": 0.07341018319129944, "20... | 34369306 | BACKGROUND A double-blind RCT on the short-term efficacy of nicotine patches compared to placebo patches among Dutch adolescents was conducted. The findings demonstrated that nicotine patches are efficacious for smoking cessation at end-of-treatment; however, only in highly compliant participants. We tested whether the... | Long-term efficacy of nicotine replacement therapy for smoking cessation in adolescents: a randomized controlled trial. |
{"1011": 0.14179791510105133, "1043": 0.6080870032310486, "1155": 0.02412080205976963, "1157": 0.4190443754196167, "2004": 0.24171993136405945, "2008": 0.08961215615272522, "2029": 0.4337083101272583, "2064": 0.20660123229026794, "2065": 1.108330488204956, "2078": 0.9739698171615601, "2109": 0.12470348179340363, "2119"... | 34378726 | Early views of autoimmune disease cast IFNγ as a prototypic pro-inflammatory factor. It is now clear that IFNγ is capable of both pro- and anti-inflammatory activities with the functional outcome dependent on the physiological and pathological setting examined. Here, the major immune modulatory activities of IFNγ are r... | Interferon gamma in autoimmunity: A complicated player on a complex stage. |
{"1011": 0.22548456490039825, "1017": 0.272677481174469, "1038": 0.3177432417869568, "1040": 0.3757305145263672, "2004": 0.16524957120418549, "2011": 0.401551216840744, "2012": 0.2447827309370041, "2029": 0.26146242022514343, "2034": 0.1751343309879303, "2044": 0.2689530849456787, "2048": 0.4974553883075714, "2050": 0.... | 34386619 | The Bacillus subtilis clpC operon is regulated by two stress induction pathways relying on either sigmaB or a class III stress induction mechanism acting at a sigmaA-like promoter. When the clpC operon was placed under the control of the isopropyl-beta-D-thiogalactopyranoside (IPTG)-inducible Pspac promoter, dramatic r... | The first gene of the Bacillus subtilis clpC operon, ctsR, encodes a negative regulator of its own operon and other class III heat shock genes. |
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