dedup-isc-ft-v107-score float64 0.3 1 | uid stringlengths 32 32 | text stringlengths 1 17.9k | paper_id stringlengths 8 11 | original_image_filename stringlengths 7 69 |
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0.37146 | c2b0937afe4c4931a21c9541acd43722 | Influence of different light qualities on chlorophyll concentrations of mung bean sprouts (mg/g DW). Mung bean seeds of three cultivars were germinated and grown under dark or light conditions for 6 days. “-1” and “SH1” means Su Huang No.1, “-5” and “ZL5” means Zhong Lv No.5, “-13” and “ZL13” means Zhong Lv No.13; “CK”... | PMC10025981 | gr1.jpg |
0.479147 | e97ef8be09e94b38804896d52af54570 | Influence of different light qualities on carotenoid compositions and concentrations of mung bean sprouts (μg/g DW). Mung bean seeds of three cultivars were germinated and grown under dark or light conditions for 6 days. “SH1” means Su Huang No.1, “ZL5” means Zhong Lv No.5, “ZL13” means Zhong Lv No.13; “CK” means dark ... | PMC10025981 | gr2.jpg |
0.378338 | f257659ef19745afa644245807bbe27e | Influence of different light qualities on tocochromanol concentrations of mung bean sprouts (μg/g DW). Mung bean seeds of three cultivars were germinated and grown under dark or light conditions for 6 days. “SH1” means Su Huang No.1, “ZL5” means Zhong Lv No.5, “ZL13” means Zhong Lv No.13; “CK” means dark control, “WL” ... | PMC10025981 | gr3.jpg |
0.419154 | 4a024048f8784708b6986856c4088f4d | Related gene expression levels of carotenoid and tocochromanol biosynthesis pathway in mung bean sprouts exposed to dark or different light quality treatments. The values show the expression relative to Actin as means ± SD (n = 3). HPP, 4-hydroxyphenylpyruvate; HGA, homogentisic acid; MBPQ, 2-methyl-6-phytylbenzoquinol... | PMC10025981 | gr4.jpg |
0.495086 | 67f2c2f470a54cccb643ed4ddb498a8a | Pearson correlations between compounds and gene expression in the synthesis pathway of (A) tocochromanols (B) carotenoids. Colored circles represent correlation is significant at the 0.05 and 0.01 levels. The number of samples used for correlation analysis was 36, including 3 replicates of each genotype. | PMC10025981 | gr5.jpg |
0.575072 | 2a18b09e14ef4387a4b939e8315b9b6d | The relationship between whether there was a storm in the 48 hours prior to capture (yes, darker shade; no, lighter shade) and (A) fat mass, (B) total body water, (C) lean mass and (D) hematocrit of male (blue) and female (grey) grasshopper sparrows (A. savannarum, n = 325 for A, B and C, n = 263 for D). The black poin... | PMC10026549 | coad011f1.jpg |
0.413563 | d8584f017d184a5695ee6e6dac58ca5c | The relationship between the average wet bulb temperature (°C, wet bulb temperature is an index of temperature and humidity) in the week prior to capture and the fat mass (g) of grasshopper sparrows (A. savannarum). Each point represents one individual (n = 325). | PMC10026549 | coad011f2.jpg |
0.434938 | a654e858b9a54f59a332b888a9e4bcf9 | Schematic of sample acquisition for analysis.A) CD90 positive mesenchymal stromal cells isolated from breast cancer patients express a unique gene expression profile indicative of increased cell to cell signaling. MSCs were isolated from fresh stromal tissue adjacent to an invasive lesion (tumor-associated) or distal t... | PMC10027225 | pone.0282473.g001.jpg |
0.467128 | 32982ca0969d4bb18edf6a547f053ca2 | Gene expression analysis of patient-derived stromal and tumor samples.A) Principal component analysis (PCA) of gene expression profiles from MSCs isolated from patients. PCA of 35,264 transcripts expressed in MSCs isolated from unaffected young individuals (normal), unaffected tissue from breast cancer patients (PNS), ... | PMC10027225 | pone.0282473.g002.jpg |
0.472166 | 365e8950731b4c9e9619487b8bd69ccb | Single cell analysis of patient-derived MSCs.A) CD90+ cells were isolated from normal donors or patients with invasive breast cancer and subjected to single cell analysis. Gene expression profiles from single cells were clustered using tSNE, and 7 distinct cell clusters were observed. B) Candidate gene expression profi... | PMC10027225 | pone.0282473.g003.jpg |
0.478081 | 3031a53d6b7f49be8b6e91edf232ef67 | Pathway and ontology analyses reveal that patient-derived MSCs demonstrate unique properties.A) Dot plot of proportion of cells in the respective cell clusters (Other, Chondrogenic, Patient-specific) expressing each gene (dot size), and average expression (color scale). B) Ontology and GSEA enrichment plots demonstrati... | PMC10027225 | pone.0282473.g004.jpg |
0.510855 | c3504407ee6e48a3ab56713a62138295 | MSC-related gene expression can be observed in whole tumor single cell RNAseq.UMAP visualization of 130,246 cells analyzed by scRNA-seq and integrated across 26 primary breast tumors (from Wu et al [34]). Clusters were annotated for their cell types as predicted using canonical markers for epithelial cells (EPCAM), pro... | PMC10027225 | pone.0282473.g005.jpg |
0.46937 | 998b422b968649668ff01c6fd68362cd | Treatment of MSCs with TGFβ inhibitor affects interactions with cancer cells.A) Cell proliferation assay of patient-derived or donor-derived MSCs treated with TGFβ-R1 inhibitors or control (DMSO). Points represent means with SEM. Significance was calculated by two-way repeated measures ANOVA using Tukey post hoc test a... | PMC10027225 | pone.0282473.g006.jpg |
0.389572 | 4b694bebc2084b138ecb1d6658eb05ad | Native mass spectrometry of C145S SARS-CoV-2 Mpro.From left to right, peaks show monomers cleaved (blue semicircle) an uncleaved (red semicircle), dimers formed by cleaved (blue circles) or half-cleaved (blue-red circle) particles, trimers formed by two cleaved and one uncleaved particles (two thirds blue, one-third re... | PMC10027274 | 41467_2023_37035_Fig1_HTML.jpg |
0.40747 | 3f9dfda9cd7c4ee5b62ce508f932f478 | Cryo-EM data processing schematic for C145S SARS-CoV-2 Mpro.a Aligned micrographs, with scale bar at the bottom. b CTF-function calculated from obtained micrographs. c Extracted particles examples. d Detailed schematic of steps taken for final reconstruction, highlighting obtained 2D and 3D classes, and first high-reso... | PMC10027274 | 41467_2023_37035_Fig2_HTML.jpg |
0.447901 | a661cc3c83724504a7e8c702ba38a220 | A. Overview of SARS-CoV-2 C145S Mpro cryo-EM model.a Four-sides rotation view of final map displayed as surface, with chains A and B coloured in white and grey, respectively, and active site peptide map coloured in cyan. b Chain A (blue) domain III model fitted into final map (grey). c Chain A (blue) and B (salmon) int... | PMC10027274 | 41467_2023_37035_Fig3_HTML.jpg |
0.42072 | 30e0acdf3dfd434bb578ea69921249ff | Detailed view on Mpro C145S peptide interaction.a Active site view of Mpro C145S chain A surface (in grey) bound to nsp4-nsp5 peptide (yellow sticks). Subsites are denotated from S4 to S5’. b Detailed view of Mpro C145S chain A active site residues (in grey) bound to nsp4-nsp5 peptide (yellow sticks), with cryo-EM map ... | PMC10027274 | 41467_2023_37035_Fig4_HTML.jpg |
0.396617 | 519cfc3e1bec44628ef5a298cf63d63b | Schematic representation of in solution dynamics of SARS-CoV-2 C145S Mpro monomeric form (sample 1) analyzed with SEC-MALS.a Control reaction containing monomers at 0 h (top), after 24 h incubation (middle) and after 48 h (bottom). b Monomers conversion reaction in presence of non-covalent inhibitor MAT-POS-e194df51-1 ... | PMC10027274 | 41467_2023_37035_Fig5_HTML.jpg |
0.423658 | 48afde283ebd48ce8a320156cd166409 | Schematic representation of in solution dynamics of SARS-CoV-2 C145S Mpro tetrameric form (sample 2) analyzed with SEC-MALS.a Control reaction containing tetramers at 0 h (top), after 24 h incubation (middle) and after 48 h (bottom). b Tetramers conversion reaction in presence of non-covalent inhibitor MAT-POS-e194df51... | PMC10027274 | 41467_2023_37035_Fig6_HTML.jpg |
0.431575 | c2f7e54649e644eb8129c00efb0043ce | Cartoon model of X-ray structure of Mpro C145S bound to Nirmatrelvir, with chain A showed in yellow, and chain B showed in blue.Ser1 and Gln-1 alpha carbons are highlighted as red spheres. Native Mpro is shown as grey transparent cartoon, with Ser1 alpha-carbon highlighted as a green sphere. | PMC10027274 | 41467_2023_37035_Fig7_HTML.jpg |
0.412492 | 980f1a1b4b994650bda3ff7f033284bd | Active site comparison between apo and intermediary states of Mpro.a Key active site residues (green sticks) of Mpro in apo form (top), cartoon view of active site in apo state in yellow (middle) and calculated electrostatic potential projected into surface of Mpro active site (bottom). b Key active site residues (gree... | PMC10027274 | 41467_2023_37035_Fig8_HTML.jpg |
0.391393 | 55f37ff6c79841f4904f5088040fe943 | SBS signaturesin WM compared with MM. | PMC10027506 | BLOODA_ADV-2022-008876-gr1.jpg |
0.442913 | f416bea9c2a348b9a8a6167741972f03 | Clonal and subclonal contribution of SBS signatures in WM. 96-class profile of genome-wide SBS mutations at the (A) clonal and (B) subclonal level. (C) SBS mutational signatures obtained after collapsing all genome-wide mutations at the clonal and subclonal level. (D-E) 96-class profile of SBS mutations specific to the... | PMC10027506 | BLOODA_ADV-2022-008876-gr2.jpg |
0.433001 | f695833cc4a447e6bf3e2ebcbb5c000a | Structural variants in WM. (A) Example of a chromoplexy event between chromosomes 1, 6, 10, and 12. (B-D) Examples of structural variants affecting driver genes: translocations affecting NFKB2 (B/C) and MEF2B (D). (E) Total number of structural variants by disease stage. | PMC10027506 | BLOODA_ADV-2022-008876-gr3.jpg |
0.44268 | 5ccab7ea19c64f6d9346846b4568c0d9 | Copy number profiles from Waldenström's macroglobulinemia. Cumulative copy number profiles across samples with (A) IgM MGUS or symptomatic precursor WM, and (B) symptomatic and treatment-exposed Waldenström's macroglobulinemia. Samples from patients with asymptomatic disease that later progressed were considered togeth... | PMC10027506 | BLOODA_ADV-2022-008876-gr4.jpg |
0.434995 | 862ba5572add46d5805b2e606210f494 | Molecular timing analysis. Copy number profiles from; (A) MYD88-wt sample, demonstrating gains in chromosomes 3, 5, 12, 15, 16, (B) MYD88-wt sample with gain in chromosome 12, (C) MYD88-mutant sample with gain of 3q and (D) MYD88-mutant sample with gains of chromosomes 4 and 18. (E-H) Molecular timing analysis for the ... | PMC10027506 | BLOODA_ADV-2022-008876-gr5.jpg |
0.472077 | e2c34b07fcd445838676af48f61debb9 | Pre-extracorporeal membrane oxygenation (ECMO) conventional protective ventilation compared to ultra-lung protective mechanical ventilation during ECMO. ACV assist-control ventilation, BIPAP-APRV bilevel positive airway pressure-airway pressure release ventilation, RR respiratory rate, PEEP positive end-expiratory pres... | PMC10027594 | 13054_2023_4372_Fig1_HTML.jpg |
0.429854 | ba880c2df01d4c8aa6f5a31deca00362 | Tools to set positive end-expiratory pressure on venovenous extracorporeal membrane oxygenation (VV-ECMO). RCT randomized controlled trial, CT computed tomography | PMC10027594 | 13054_2023_4372_Fig2_HTML.jpg |
0.425567 | 77ce61fda99246c7b61b89d4379e2903 | Inner side patient's right thigh. a Wound upon arrival in the nutrition department: fibrinous edges and necrotic central zone. b Intermediate state after wound trimming, during VAC therapy: diameter of the wound was reduced and substance is regained. c After the skin graft: healthy edges and good epidermalization. VAC,... | PMC10028363 | ofa-0016-0212-g01.jpg |
0.41856 | 43b7a2964c4e49c28ebe30f4dbae158a | Integral
carbon selectivity and methanol throughput values calculated
until the moment when conversion of methanol drops below 75%. Reaction
conditions: (a) 350 °C, 25 mg of catalyst, 0.75 kPa of MeOH,
carrier −10 mL·min–1 He, WHSV 0.3 h–1; (b) 400 °C, 25 mg of catalyst, 6 kPa of MeOH,
carrier −30 mL·min–1 He, WHSV 6 h... | PMC10028611 | cs3c00059_0001.jpg |
0.399732 | 90ed83b3c2094c4e928faa6f40bc38ce | Total amounts of methanol converted normalized
by number of BAS
for respective catalysts. | PMC10028611 | cs3c00059_0002.jpg |
0.45142 | 450a05828e7e472088077cf39a03f047 | Ion signal as a function of m/z and photon energy from the detected products
and intermediates over
HZSM-5 (a) and Ca/ZSM-5 (b) catalysts during the MTH reaction. Reaction
conditions: 350 °C; 100 mg of the catalyst, 12.3 kPa of methanol,
carrier −75 mL·min–1 He. The data acquisition
took 8 h for each catalyst. | PMC10028611 | cs3c00059_0003.jpg |
0.435183 | 68f48cf760344a3a9da251d95121e436 | Comparison of recorded and literature photoelectron spectra42−48 for selected m/z = 30, 42, and
58 channels over HZSM-5 (left) and Ca/ZSM-5 (right), corresponding
to various oxygenate and hydrocarbon species. Reaction conditions:
350 °C, 100 mg of the catalyst, 12.3 kPa of methanol, carrier
−75 mL mL·min–1 He. | PMC10028611 | cs3c00059_0004.jpg |
0.511922 | f1157f5567cc4279901db5ec4770ac66 | Step-response MTH experiments performed at 350 °C. (a) Total
hydrocarbon traces of all catalysts compared to Ar tracer. (b) Amount
of hydrocarbons eluted from zeolites after methanol was switched off.
Conditions: 350 °C, 50 mg of catalyst, 18.3 min switch, 5 mL·min–1 He flow with 1.5 kPa of MeOH + 5 mL·min–1 side flow ... | PMC10028611 | cs3c00059_0005.jpg |
0.426193 | ae0d324d67034fadaf02e6a8e1e60f26 | Operando TGA profiled recorded during switching from methanol-containing
He flow to dry He over HZSM-5, Ca/ZSM-5 and Na/ZSM-5 catalysts. (a)
TGA profiles and amount of adsorbates retained and flushed during
three methanol switches for ZSM-5 catalysts (inset). (b) MS profiles
of m/z = 31 signal corresponding
to methanol... | PMC10028611 | cs3c00059_0006.jpg |
0.446209 | 291143f8bbd64a21956ef930d6694610 | 1H–13C CP MAS NMR of the used catalysts
from continuous flow experiments after 10 min (a) and 3 h (b) on stream.
Conditions: 350 °C, 100 mg of the catalyst; carrier −30
mL·min–1 He, 12 kPa of 13C MeOH.
Sidebands are denoted with asterisks. | PMC10028611 | cs3c00059_0007.jpg |
0.466873 | 0fe473cf85014508a597629ab3d83c4b | 1H–13C{1H} HETCOR
MAS NMR
2D of the used catalysts from continuous flow experiments after 3
h of stream. Conditions: 350 °C, 100 mg of catalyst, carrier
−30 mL–1·min He, 12 kPa of 13C MeOH. | PMC10028611 | cs3c00059_0008.jpg |
0.472263 | a722d5068f5341b3ada073a233af8c42 | Enlarged
regions of Δ abs spectra: (a–c) OH-region
and (d–f) region of methanol adsorption, and (g–i) 1750–1300
cm–1 region. Δ abs spectra were obtained by
subtraction of the first spectrum recorded at 350 °C in absence
of methanol from all other spectra. Conditions: 350 °C, 15 mg
of catalyst pellet, carrier −130 mL·mi... | PMC10028611 | cs3c00059_0009.jpg |
0.424632 | d48e279ca1014104a94e7700226951b4 | Bands of interest integrated from Δ abs spectra
from operando
IR measurements for ZSM-5 catalysts in presence and absence of the
methanol feed: (a) BAS, (b) EfAl and Ca-OH, (c) methoxy groups, and
(d) polymethylated benzenes. Conditions: 350 °C, 15 mg of catalyst
pellet, carrier −130 mL·min–1 He, 0.12
kPa of MeOH. | PMC10028611 | cs3c00059_0010.jpg |
0.475789 | 8d97ace8045841298ee2d4e79ff021f4 | IR measurements of ZSM-5
catalysts combined with temperature-programmed
experiments with water. Conditions: 150–500 °C, heating
rate 5 °C·min–1, 15–20 mg of catalysts,
carrier −130 mL·min–1 He, 0.07 kPa of
water. | PMC10028611 | cs3c00059_0011.jpg |
0.434043 | f4a1877465cb42afa917b749c816ee3b | (a) Positions within the catalyst bed where
the XRD data were acquired.
(b–d) Unit cell volumes derived from Rietveld refinement of
operando XRD data for HZSM-5, Ca/ZSM-5, and Na/ZSM-5 catalysts and
after 5 h on stream and subsequent switch off the methanol for 30
min; MS spectra of the reaction are attached below. Con... | PMC10028611 | cs3c00059_0012.jpg |
0.418751 | 857b375807a34d8e9d839da42c084141 | Type of antimicrobial stewardship recommendation. | PMC10028943 | S2732494X2300133X_fig1.jpg |
0.394368 | 68481da37c9a4a449a8d712ce31d1691 | Intensive care unit stay in patients receiving elective coronary artery bypass grafting. Patients who had elective coronary artery bypass grafting are divided by temperature upon ICU admission. Their intensive care unit stays were plotted. | PMC10030842 | 41598_2023_31889_Fig1_HTML.jpg |
0.418096 | 3a06421761114f3ba618b19b4e65ea9e | Literacy rate by province and gender in Pakistan. Source: Author construction based on data from PSLM Bureau of Statistics, Pakistan. Figure 2 displays the trend of per capita income from 2005 to 2019, one of the inevitable indicators of educational achievement. The statistics calculate a sharp drop in per capita incom... | PMC10031191 | 13132_2023_1222_Fig1_HTML.jpg |
0.513661 | 8a82583f500f4f5cad4fd8fd13199ce8 | Household’s income in Pakistan. Source: Author construction based on data from PSLM Bureau of Statistics, Pakistan. Figure 2 displays the trend of per capita income from 2005 to 2019, one of the inevitable indicators of educational achievement. The statistics calculate a sharp drop in per capita income after 2010, whic... | PMC10031191 | 13132_2023_1222_Fig2_HTML.jpg |
0.453709 | 65741625ddfb4d85b0078d71e64ccf73 | Education attainment by age (2005–2019). Source: Author construction based on data from PSLM Bureau of Statistics, Pakistan. Figure 3 expresses the predictive margins between the age of the persons living in the household and their education levels. The probability of primary education attainment decreases after 25 yea... | PMC10031191 | 13132_2023_1222_Fig3_HTML.jpg |
0.441619 | f3902bba5caf4a8fb83fe6734a2cdb98 | Flowchart of the experimental design for RNA-seq and data analysis | PMC10031896 | 12864_2023_9214_Fig1_HTML.jpg |
0.372155 | 5e5df52b0a94427b970acab1198a2e98 | Overview on the expression data. A Normalization boxplot representing sequencing depth and rescaled log2 counts per million for 16 time points (16*3 biological replicates). B Gene-wise variance estimation, mean vs. standard deviation plot for normalized row-wise gene counts. The horizontal red line is the median estima... | PMC10031896 | 12864_2023_9214_Fig2_HTML.jpg |
0.458404 | 2f7b37df45904355a4944db85ac6c6b6 | Clustered and scaled expression patterns for the top 500 differentially expressed (DE) genes. Each group represents a gene expression pattern shared among different DE genes | PMC10031896 | 12864_2023_9214_Fig3_HTML.jpg |
0.447092 | 703fad7ee9594fd18b26845aab7ca465 | Putative regulatory motifs for clusters enriched in genes associated with pathogenicity, exocytosis and vesicle transport, ion channels and calcium binding proteins, plant cell wall degrading enzymes and transcription factors. The X-axis in the expression profile shows 16 time-points of Pl. halstedii lifecycle and on t... | PMC10031896 | 12864_2023_9214_Fig4_HTML.jpg |
0.458402 | e930c13e95644a91a5a517fb713a9748 | Bending-induced 5-fold twin formation in a single-crystalline
Au
nanocrystal. (a) TEM image of a single-crystalline Au nanocrystal.
(b–e) Successive emission of partial dislocations on four different
twinning systems in the Au nanocrystal. The GB angle increases from
12 to 16° upon bending. (f) Transformation of SF bun... | PMC10032584 | nl2c03852_0001.jpg |
0.499527 | 44e93bcdc26942de9d5ac71eb4fd0f6f | MD simulation showing
the atomic-scale process of 5-fold twin formation
in a single-crystalline Au nanocrystal upon bending. (a) The bending
Au nanocrystal before defect nucleation. (b) Successive partial dislocations
emit from the free surface and terminate near the neutral plane, resulting
in the formation of a TB an... | PMC10032584 | nl2c03852_0002.jpg |
0.464157 | fe50b919024a441ea118bb8c0c0c3e78 | Shear- and tension-induced
formation and dissolution of a 5-fold
twin in a multifold twinned nanocrystal. (a) An as-fabricated Au nanocrystal
with a 4-fold twin structure. The nanocrystal is viewed along [1̅10].
(b) Formation of a 5-fold twin via successive twinning partial slip
along the preexisting SF and TBs. (c–g) ... | PMC10032584 | nl2c03852_0003.jpg |
0.47789 | e888b5ca7266422bb6cec5475ce75942 | MD simulation showing atomic-scale processes
of 5-fold twin formation
in the Au nanocrystal and Σ9 GB decomposition. (a) A Au nanocrystal
with a TB intersected with a Σ9 GB under ⟨112⟩
compression. (b) Formation of four TBs via Σ9 GB decomposition
upon compression. (c–f) Adjustment of the FFT via a series
of partial di... | PMC10032584 | nl2c03852_0004.jpg |
0.474608 | 4c3c5752760445d38fef26c274edd2e0 | FFT formation
in the neck area of a Au nanocrystal with a TB parallel
to the tensile loading direction. (a, b) In situ atomic-scale
observation of FFT formation in the neck of the Au nanocrystal loaded
along ⟨112⟩ direction at room temperature under a strain
rate of 10–3 s–1. The nanocrystal
is viewed along [1̅10]. All... | PMC10032584 | nl2c03852_0005.jpg |
0.478286 | 975fef6603484bd78544ff869729cad3 | The molecular structure, in vitro pan-genotype and -serotype activity, and mechanism of action of JNJ-1802.a, The molecular structure of JNJ-1802. b, In vitro antiviral activity in Vero E6 cells against a panel of clinical isolates23. Data are mean EC50 values. The asterisk and hash symbols indicate that the DENV strai... | PMC10033419 | 41586_2023_5790_Fig1_HTML.jpg |
0.457325 | bc4c3aed70674460897c4090ce77f79b | In vivo efficacy of JNJ-1802 (b.i.d.) against DENV-1–4 after infection in AG129 mice.a, Schematic of viraemia studies against DENV-2. b, The effect of JNJ-1802 on viraemia on day 3 after infection in DENV-2-infected mice treated b.i.d. with 60, 20, 6, 2, 0.6, 0.2 mg per kg per day JNJ-1802 (n = 7, 14, 14, 16, 16 and 13... | PMC10033419 | 41586_2023_5790_Fig2_HTML.jpg |
0.459826 | 35d67db3c7a0455093bab0e5ec251e2a | In vivo efficacy of JNJ-1802 against DENV-2 in NHPs by measuring viral RNA load, NS1 protein, IgM/IgG response and TCID50.a, Schematic of the viraemia studies using rhesus macaques. b, The effect of JNJ-1802 on viral RNA in plasma of rhesus macaques (R1–R12) treated q.d. with vehicle, or 0.01, 0.18 or 3 mg per kg per d... | PMC10033419 | 41586_2023_5790_Fig3_HTML.jpg |
0.472997 | 83f1b4b0fdc2443cb097d41094a19a3c | The in vivo efficacy of JNJ-1802 against DENV-1/45AZ5 was examined in NHPs by measuring viral RNA load and IgM/IgG response.a, Schematic of the DENV-1/45AZ5 study. b, The effect of JNJ-1802 on viral RNA in rhesus macaques (R1–R12) infected with DENV-1/45AZ5 (0.5 ml at 1.2 × 105 PFU per ml) and treated with JNJ-1802 at ... | PMC10033419 | 41586_2023_5790_Fig4_HTML.jpg |
0.495306 | ea9238576a5d4cce8f737de1ae500d0e | In vitro resistance selection profile of JNJ-1802 against DENV-2.a, b, The dynamics of emerging mutations were studied using whole virus genome sequencing in two independent experiments (Experiment A (a) and experiment B (b)). Each coloured line shows the kinetics of appearance of a particular mutation during virus pas... | PMC10033419 | 41586_2023_5790_Fig5_ESM.jpg |
0.516364 | 74004240f005448ba5996d3a3332720c | JNJ-1802 prevents DENV NS3-NS4B interaction.a, b, Huh-7 cells stably expressing T7 RNA polymerase and DENV-2 NS2B-NS3 were transfected with T7-based expression plasmids encoding NS4A-2K-NS4B(-HACt) (NS4B corresponding to wild-type [WT] or mutant NS4B). Four hours post-transfection, cells were treated with various conce... | PMC10033419 | 41586_2023_5790_Fig6_ESM.jpg |
0.429272 | f3e2cf9a842d4ffd97d3ae6cbc41aced | In vivo efficacy of JNJ-1802 against DENV-2 infection, dosed once-daily for 3 days.a, Schematic outline of a viraemia study using AG129 mice adapted from Kaptein et al.3
b, Effect of JNJ-1802 on viraemia on Day 3 post-infection (p.i.) in mice orally treated once daily (q.d.) with a dose of 30, 3 or 0.3 (n = 8 for all g... | PMC10033419 | 41586_2023_5790_Fig7_ESM.jpg |
0.480829 | a5775fb9f4e24e70854242cc1094a9ec | In vivo efficacy of JNJ-1802 against DENV-2 infection, dosed twice daily for 6 days.a, Schematic of the in vivo kinetics study. Compound administration started 1 h before infection and continued twice daily (b.i.d.) for 6 consecutive days. Each treatment group (n = 8) was equally divided into sub-groups A and B for blo... | PMC10033419 | 41586_2023_5790_Fig8_ESM.jpg |
0.496166 | cd67ee3b2d7e473ab4dbfb55297c0b1b | Individual and mean JNJ-1802 plasma concentration-time profiles in non-human primates.a, Weight curves (mean values + standard deviation) of rhesus macaques in the different treatment groups (n = 3 per group, except for Day 3, n = 1 for 0.01 mg/kg/day and 0.18 mg/kg/day groups and n = 2 for 3 mg/kg/day group). b, Mean ... | PMC10033419 | 41586_2023_5790_Fig9_ESM.jpg |
0.529606 | c5e107ffbeae4a22a26c271730456369 | Overall progression of individuals through study. | PMC10035812 | pone.0280638.g001.jpg |
0.494815 | 4c3c087575ef4e05af0b555c17a2c98b | The flow chart of patient selection and data analysis. | PMC10036588 | fsurg-10-1110040-g001.jpg |
0.455227 | 86e6dd105b7f42cd9c454a9b168683d6 | Nomograms to predict 1-, 3-, and 5-year OS or CSS of NEPC patients. (A) Nomogram for OS; (B) Nomogram for CSS. | PMC10036588 | fsurg-10-1110040-g002.jpg |
0.47166 | 74abe22dd0204bb88463eb1133d91ff4 | ROC curves to analyze the accuracy of the nomogram for 1-, 3-, and 5-year OS and CSS. ROC for OS at 1-year (A), 3-year (B), 5-year (C) in training group; ROC for OS at 1-year (D), 3-year (E), 5-year (F) in validation group; ROC for CSS at 1-year (G), 3-year (H), 5-year (I) in training group; ROC for CSS at 1-year (J), ... | PMC10036588 | fsurg-10-1110040-g003.jpg |
0.453617 | b9c72879ed284a619ace7ae9e39050d1 | Calibration curves of the 1-, 3-, and 5-year OS of NEPC patients. 1-year (A), 3-year (C), 5-year (E) OS in training group; 1-year (B), 3-year (D), 5-year (F) OS in validation group. | PMC10036588 | fsurg-10-1110040-g004.jpg |
0.460438 | 503d1e471d5144f29319061c47c818f9 | Calibration curves of the 1-, 3-, and 5-year CSS of NEPC patients. 1-year (A), 3-year (C), 5-year (E) CSS in training group; 1-year (B), 3-year (D), 5-year (F) CSS in validation group. | PMC10036588 | fsurg-10-1110040-g005.jpg |
0.434157 | 402d219cfe07484bb95825b66a6ce11a | DCA curves of the 1-, 3-, and 5-year OS of NEPC patients. 1-year (A), 3-year (B), 5-year (C) OS in training group; 1-year (D), 3-year (E), 5-year (F) OS in validation group. | PMC10036588 | fsurg-10-1110040-g006.jpg |
0.406286 | 13ea7f8133944fe886429917e5ff1a5c | DCA curves of the 1-, 3-, and 5-year CSS of NEPC patients. 1-year (A), 3-year (B), 5-year (C) CSS in training group; 1-year (D), 3-year (E), 5-year (F) CSS in validation group. | PMC10036588 | fsurg-10-1110040-g007.jpg |
0.459031 | c9f7ef6b3ae042099e284e0c02829856 | Kaplan–meier curves of OS and CSS of NEPC patients by different risk levels. OS in training set (A) and validation set (B); CSS in training set (C) and validation set (D). | PMC10036588 | fsurg-10-1110040-g008.jpg |
0.405042 | d6e246d3e754443ba115fa681172308f | The rockburst in certain tunnel. | PMC10036632 | 41598_2022_27058_Fig1_HTML.jpg |
0.456517 | b1532884173145c2ab484520ea9c492a | Dynamic change diagram. | PMC10036632 | 41598_2022_27058_Fig2_HTML.jpg |
0.38712 | 29fd2545b4b44b8ebe71fc38e3403573 | Diagram of opposite fuzzy sets. | PMC10036632 | 41598_2022_27058_Fig3_HTML.jpg |
0.40781 | a6ee1bda7d5d49dcbb0afa33d34022fc | Diagram of relative difference function. | PMC10036632 | 41598_2022_27058_Fig4_HTML.jpg |
0.436206 | 77d16b0b790a4ff49ec68f05a37742d5 | The drawing of position relation. | PMC10036632 | 41598_2022_27058_Fig5_HTML.jpg |
0.458202 | 4d7e081005e14c9cb01a50f89eabee91 | Location of ventilation shafts of tunnel. | PMC10036632 | 41598_2022_27058_Fig6_HTML.jpg |
0.52116 | 5f6bd9e812684dc8afc0b53f911528a3 | Diagram of ventilation scheme of Zhongnanshan Highway Tunnel. | PMC10036632 | 41598_2022_27058_Fig7_HTML.jpg |
0.395932 | 3adc9ace3e4945d79d52df29015bfd33 | 2 # shaft tower. | PMC10036632 | 41598_2022_27058_Fig8_HTML.jpg |
0.413797 | 2da0b14fb1ac4884b65b950f88aae1e7 | The risk evaluation process of rockburst intensity. | PMC10036632 | 41598_2022_27058_Fig9_HTML.jpg |
0.480937 | 6e877d8bdb7c49e2a211cd433ffec4da | The effect of job stress on implementation quality was moderated by teachers’ perception of feasibility of PAX GBG + MTP. Teachers experiencing high levels of stress and felt the program was harder to use demonstrated greater (A) instructional support, and (B) classroom organization than those who were highly stressed ... | PMC10036766 | fpsyg-14-1059138-g001.jpg |
0.420942 | a02d3e5c44e74fe497b1589490e81f07 |
Indications for thrombolysis.
aSystolic blood pressure < 90 mm Hg or drop of > 40 mm Hg not explained by another cause. bHeart rate < 40 bpm | PMC10037295 | WJCC-11-1702-g001.jpg |
0.476443 | 8a328c8ff50b4a35a9d245114b10e3bc |
Thrombolysis contraindications according to societal guidelines. BP: Blood pressure; CPR: Cardiopulmonary resuscitation. | PMC10037295 | WJCC-11-1702-g002.jpg |
0.474272 | 2f9553a90acc4b80abe0f87d19d86353 |
Diagnostic strategy in suspected cases of pulmonary embolism. PE: Pulmonary embolism; CTPA: Computed pulmonary tomography angiography. | PMC10037295 | WJCC-11-1702-g003.jpg |
0.459844 | e8e5fc7930b34056bc49d42a7d34b83e | Virtual Pharmacy Cardiac Optimization Clinic pathway. | PMC10037589 | pharmacy-11-00048-g001.jpg |
0.467594 | b2ee9c41a6544533950326564a3c709a | Anticoagulation initiated following PCOC enrollment. | PMC10037589 | pharmacy-11-00048-g002.jpg |
0.489959 | 2a7ff02b0cdd480aa51bf7272cba8543 | Recruitment and participation of the study. | PMC10038253 | pone.0283500.g001.jpg |
0.489232 | eb3ce39e4d8f45a78f27be1eb696b844 | Mediation model of the effects of demoralization on the relationship between fear and PTSD in both (A) high-risk group (N = 148) (Sobel’s test: Z = 3.64, p < 0.001) and (B) low risk group (N = 203) (Sobel’s test: Z = 3.72, p < 0.001). (FCV-19S = The Fear of COVID-19 Scale; DS-MV = Demoralization Scale—Mandarin Version;... | PMC10038253 | pone.0283500.g002.jpg |
0.458672 | 7eb68b4c14c64c2d8bf26a3fcd5181d8 | Mediation model of the effects of burnout and teamwork on the relationship between DASS and quality of life.(N = 351) (DASS = Depression, Anxiety, Stress Scale; CBI = Copenhagen Burnout Inventory; TPOT = Teamwork Performance Observation Tool; PM = the ratio of the indirect effect to the total effect). | PMC10038253 | pone.0283500.g003.jpg |
0.467955 | b006f1d100c34d75bbc12329384c37b1 | Map of Kenya and Uganda showing the location of buffalo sampling sites in Northern Uganda (Kidepo and Murchison Falls National Parks) and central Kenya (Ol Pejeta conservancy and the Maasai Mara game reserve) | PMC10039833 | 251_2022_1287_Fig1_HTML.jpg |
0.424374 | fa175f24c0974a978a3b6d28d7666d5b | Box plot displaying the number of retained illumina reads after a stepwise filtering criterion. Central lines show the medians; box limits indicate the 25th and 75th percentiles as determined by R software; whiskers extend 1.5 times the interquartile range from the 25th and 75th percentiles; outliers are represented by... | PMC10039833 | 251_2022_1287_Fig2_HTML.jpg |
0.448191 | a0da73607cc2424e82e3d16473cad8df | Boxplot showing the distribution of the percent pairwise sequence identities when the antigen recognition sites of class I MHC alleles of the African buffalo are compared to alleles from different African cattle breeds and alleles from European Bos taurus | PMC10039833 | 251_2022_1287_Fig3_HTML.jpg |
0.376132 | 8f3bc061dffa4f0ab23b2d6121785da4 | Amino acid alignment of buffalo class I MHC alleles. Plus sign ( +) marks sites under positive selection, codons which have ω > 1 with a significant Bayes Empirical Bayes probability are indicated by a single asterisk (*) if P > 95% or a double asterisk (**) if P > 99%. Codons known to be involved in antigen binding in... | PMC10039833 | 251_2022_1287_Fig4_HTML.jpg |
0.399427 | 2880345589af497faf84b65b3142e4dc | Class I MHC distance tree depicting the relationship between predicted peptide-binding specificities of bovine alleles (black branch labels) and buffalo alleles (red branch labels). Alleles with similar peptide binding specificities cluster together and the closer class I MHC alleles branch, the larger the overlap betw... | PMC10039833 | 251_2022_1287_Fig5_HTML.jpg |
0.488085 | 1ada9f595ab343698890355241490ddf | Heat-map visualization of the predicted peptide binding specificity overlaps between cattle and buffalo class I MHC transcripts inferred in MHCcluster. buffalo allele names are either prefixed ‘MF’, ‘KV’ or ‘OP’. All cattle alleles are prefixed ‘BoLA’. The colour key shows the MHC specificity distances between alleles.... | PMC10039833 | 251_2022_1287_Fig6_HTML.jpg |
0.445017 | 4e2fa019fc794daa931886574fdcb089 | Logos illustrating predicted peptide-binding motifs for buffalo (upper panel) and bovine (lower panel) class I MHC proteins. The height of each stack of symbols (y-axis) represents information content (the level of amino acid conservation) in each position, the relative frequency of a particular amino acid at that posi... | PMC10039833 | 251_2022_1287_Fig7_HTML.jpg |
0.437011 | 261209a9d7624cb79341579d036a6e9f | The predicted amino acid sequences for the transmembrane (TM) and cytoplsmic domains of buffalo class I MHC. The transmembrane lengths and the cattle loci with matching transmembrane lengths are also shown. Also shown are alleles identified per animal. Where two alleles from the same animal are identical in this region... | PMC10039833 | 251_2022_1287_Fig8_HTML.jpg |
0.426924 | d49d7fd1554c440c9d683459205aec5f | Selection process of the study participants. KNHANES, Korea National Health and Nutrition Examination Survey. | PMC10040265 | kjfm-22-0133f1.jpg |
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