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olimiemma
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MIT-OCW-Transcripts

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205
went out of town
and came back three
weeks later, and they
found something must have
gone wrong with the exposure
because the hair cells are here.
They're fine.
But they figured out
later that, actually,
the supporting cells
nearby had grown back.
So that doesn't seem to help
us in the mammalian pathway.
There's some sort of
growth factor or growth
pathway in birds where
these hair cells grow back,
but not in the
mammal unfortunately.
So this is an example
from a cochlea that's
been treated by
an aminoglycoside,
and this is just to
remind me to tell you
that, once again, you can count
hair cells along the cochlea.
This is a plot of
hair cells present
where lots of black bars
means lots of hair cells.
And this is a beautiful
example of this particular drug
treatment, which I
believe is kanamycin,
and a certain dose doesn't
affect the inner hair cells
at all.
But look at the
outer hair cell loss
in the basal part of the
cochlea, virtually complete
outer hair cell loss showing
that the outer hair cells are
more sensitive, they're more
labile to this drug treatment
than are the inner hair cells.
And once again, the most
vulnerable part of the cochlea
is not the apex.
0% distance from
the apex is up here.
And the basal region
would be down here,
and that's again the
most vulnerable part
of the cochlear for some reason.
We can speculate
about why this might
be the case for drug treatment.
We don't know this,
but maybe the drug
appears in more in a
higher concentration