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in the basal part
of the cochlea.
In the cochlea, like
you have in the brain,
you have a blood-brain barrier.
You have a
blood-cochlea barrier.
Obviously, some drug has
gotten into the cochlea,
but maybe the
blood-cochlea barrier
is more permeable
down here in the base.
And in the apex not
as much drug got in.
That's an idea.
It hasn't been borne out
by experimental evidence,
but it's an idea that
people have in mind.
Or, it could be
that the outer hair
cells are just, for some reason,
easier to kill in the base.
That's more suggestive
that all of these things
affect the hair cells in
the base more than the apex.
Now, these were some of the
original experiments that
showed what outer hair cells did
for us in the sense of hearing.
So earlier in this
course, we had the effect
of knocking out the
outer hair cells
by knocking out the
gene for Prestin.
OK?
In this case, the
outer hair cells
are knocked out by
the drug treatment.
So you've lesioned
the outer hair cells
in the very basal
part of the cochlea.
The inner hair
cells are present.
Let's look at the tuning
curves from auditory nerve
fibers in that preparation.
Now let me remind you again
what's happening here.
So you have the
inner hair cells,
and you have the
outer hair cells,
which have been killed
by the drug treatment.
And then you have most of the
auditory nerve fibers coming
from the inner hair cells
in the auditory nerve going
to the brain.