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Ref. GG I2!h edp.799 Explanation: Direct Renin Inhibitor DRIs are a novel class of antihypertensive drugs that inhibit the RAS at its origin. Angiotensinogen is the only specific substrate for renin, and its conversion to AngI presents a rate-limiting step for the generation of downstream components of the RAS. Aliskir...
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They are present in Submucosa. Brunner glands secrete a mucous, alkaline fluid in response to parasympathetic stimulation. This fluid helps neutralize the acidic chyme that enters the duodenum from the pyloric stomach. The glands also manufacture the polypeptide hormone urogastrone (also known as human epidermal growth...
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A prolonged bleeding time, prolonged APTT
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Prenatal diagnosis of CAH is possible with chorion villus sampling at early weeks of pregnancy using DNA probes The 17-OHP level in the amniotic fluid is elevated Prenatal therapy with dexamethasone or termination of pregnancy is the option
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A i.e. Constricted pupil in response to light
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Arithmetic mean It is the most commonly used statistical average. To calculate mean, add up the values of all individual observation and then divide by the number of observations. The process of adding together is called summation and is denoted by the sign ∑ or S. The individual observation is denoted by ŋ The mean ...
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Ans. is 'a' i.e., Increase the dose of warfarin
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Ans. is 'd' i.e., All the above Uterovaginal prolapse:* A minor degree of prolapse may be asymptomatic but with more significant degrees the patient complains of 'something coming down'.* A cystocele (bladder prolapse) and a cystourethrocele lead to the sensation of a lump in the vagina and may also be associated with ...
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Nonselective irreversible a receptor blocker Phenoxybenzamine Nonselective reversible a receptor blocker Phentolamine Selective a receptor blocker Prazosin Terazosin Doxazosin
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Uncommon sunlight-induced whealing confined to exposed body sites. Eruption occurs within minutes of exposure and resolves in a few hours. Very disabling and sometimes life threatening. Action spectrum is UVB, UVA, and visible light or any combination thereof. Most commonly UVA. Is an immediate type I hypersensitivity ...
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D i.e. Ischemic vascular injury to muscles
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Ref: Nelson's Textbook of Pediatrics. 19th EditionExplanation:Some important definitions in Neonatology Low birth weight: Birth weight of less than 2.5 kg irrespective of gestational age Very low birth weight: Birth weight of less than 1.5 kg irrespective of gestational age.Extremely low birth weight: Birth weight of l...
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Ans. is 'c' i.e., Calcaneum
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ANSWER: (B) Renal amyloidosisREF: Robbins 8th ed chapter 6See PLATE - Key PLATE - KeyRENAL AMYLOIDOSIS:See amyloid stains in APPENDIX-24 below "HISTOLOGY/PATHOLOGY/ MICROBIOLOGY STAINS"(A) Congo red staining of renal amyloidosis: Amyloid (an abnormal protein) accumulates as extra-cellular deposits, nodular or diffuse, ...
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Ans. is 'b' i.e., Feeling of double of oneself o Doppelgangers (subjective double) is the delusion that there is double of oneself. A person feels that double of himself exists elswhere.
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First keep in your mind that any of the described complication can occur with either ICCE or ECCE. However, ECCE (leaving capsule behind) decreases the chances of many complications. Complications dereased by ECCE are:- i) Vitreous prolapse & loss ii)Endophthalmitis iii)Cystoied macular edema iv) Aphakic glaucoma v) Fi...
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When electrons from cathode strikes the anode , X rays are produced but also there is large amount of heat production and hence tungsten having high melting point(3360c) used as a target material.
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Ans. is 'c' i.e., Regional ileitis Inflammatory bowel disease o Inflammatory bowel disease (IBD) is used to represent two distinct disorders of idiopathic intestinal inflammation : i) Crohn disease or regional ileitis ii) Ulcerative colitis
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B i.e. Umbilical Vein - Umblical vein and pulmonary veins carry oxygenated bloodQ. Whereas umbilical and pulmonary aeries carry deoxygenated bloodQ. - Deoxygenated blood (with 62% 02 saturation) leave umbilical aeries to be oxygenated at placenta whereas, umbilical veins carry oxygenated blood from the placenta with Hb...
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Ans. is d. i.e. MRIRef: Shaw 16th/ed, p221 & 222The Investigation done in VVF are:* Urine culture* USG* IVP* Cystoscopy* Methylene blue 3 swab test
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A i.e. Kerosene
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Human diploid fibroblasts (HDF) cell line is used for cultivation of coxsackie A7, 9, 16; CMV; Echovirus; enteroviruses; HSV-1, 2; Poliovirus; parainfluenza virus, rhinovirus and VZV.
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Alpha cellsGlucagonBeta cellsInsulin, amylinDelta cellsSomatostatinPP cellsPancreatic polypeptideRef: Harrison 19e pg: 2403
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* Intravenous drug abusers with no history of homosex- ual behavior compose the next largest group, represent- ing about 17% of all patients. * Recipients of blood and blood components (but not hemophiliacs) who received transfusions of HIV- infected whole blood or components (e.g., platelets, plasma) account for about...
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The pressure in the oesophagus increases rapidly and the oesophagus burst at its weakest point in the lower third sending a stream of material into the mediastinum and often the pleural cavity as well. Bailey and Love&;s sho practice of surgery,26 th ed.pg:992
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Famotidine is the most potent H2 blocker.
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In fragile-X syndrome, there would be a small nose, not large. Fragile--X syndrome or Main-Bell Syndrome: Trinucleotide repeat mutation of CGG Characteristics Hyperextensible joint or high-arched palate Mitral valve prolapse FMR1 P deficiency (fragile X mental retardation 1 protein)- upregulates the metabotropic glutam...
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Ans: A i.e. Medical termination of pregnancy Medical termination of pregnancy has not been mentioned as a component of CSSM programme (1992), though it been stated as a major intervention under RCH (Reproductive and Child Health) programme.
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Schistosomiasis - is the commonest cause of calcification in the wall of bladder. Thin curvilinear calcification outlines a bladder of normal size and shape. Calcification spreads proximally to involve the distal ureters (appearing as two parallel lines) in 15%." This is maximum. I could lay my hands on. But this parag...
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Oxytocin has a half life of approximately 3-5 minutes.
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Ans is 'd' i.e., Increased level of thyroxine * Following table depicts the hormonal changes in a patient following the surgical stress:Principal Hormonal Responses to Surgical StressEndocrine glandHormonesChange in secretionAnterior pituitaryACTHIncreased Growth hormoneIncreased TSHViriable FSH/LHVariablePosterior pit...
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A i.e. Phenylephrine
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C i.e. 5 - 15 years The lateral condylar (or capitellar) epiphysis beings to ossify during the first year of life & fuses with shaft at 12-16 yearsQ. Between these ages it may be sheared off or avulsed by forceful traction. The maximum chances of injury is between 5 -15 yearsQ.
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During embryogenesis, skeletal muscle develops through the fusion of mononucleated precursor cells (myoblasts) into multinucleated myotubes. These subsequently mature into myofibers (muscle fibers) of varying length that contain thousands of nuclei. In adult tissues, these myofibers are arranged in fascicles, each asso...
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Scoliosis can be a secondary condition in such disorders as muscular dystrophy and polio in which abnormal muscle does not keep the vertebral column's normal alignment and results in a lateral curvature. Lordosis is increased secondary curvature of the lumbar region. It can be caused by stress on the lower back and is ...
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Antibodies against Desmoglein 1 : P.Foliaceous and P.erythematous Antibodies against Desmoplakin : Paraneoplastic pemphigus Antibodies against Desmocollin : Drug induced pemphigus
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The main pathogenesis underlying Lobular carcinoma is accquired loss of the tumor suppressive adhesion protein E-cadherin, also called as CDH-1.
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Right Bronchial artery is a branch of Right 3rd posterior intercostal Artery
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Ans. A i.e. Gout
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The initial treatment for cancer of the thyroid is surgical. A consensus approach might be to perform a total thyroidectomy if the primary tumor is larger than 1 cm in diameter or if there is extra-thyroidal involvement or distant metastases. Clinically evident lymphadenopathy should be removed with a neck dissection. ...
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Takatsubo cardiomyopathy is stress induced infundibular spasm resulting in LV hypokinesia . ECG shows ST elevation
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Carotid sinus pressure will produce increased baroreceptor discharge inhibits the tonic discharge of the vasoconstrictor nerves and excites the vagal innervation of the hea, producing vasodilation, venodilation, a drop in blood pressure, bradycardia, and a decrease in cardiac output.
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Ans. is 'b' i.e., Primary
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Malignant (necrotizing) otitis externa: Rapidly spreading Pseudomonas infection in immunocompromised patients. Patient presents with excruciating ear pain, profuse greenish black ear discharge & granulations on the floor of EAC. Necrosis of bone aids in spread of infection to skull base known as Lateral Skull base Oste...
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Ans. is 'd' i.e., Ornithine transpoer Hyperornithinaemia, hyperammonaemia, homocitrullinuria (HHH) syndrome is an autosomal recessive disorder of ornithine transpo caused by mutations in gene SLC 25A15 encoding the ornithine transoer protein (ORNT1).There is defective activity of the ornithine transpoer across the mito...
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Ans. (d)DTH responses are generally the first effective responses involved in clearance of intraendosomal microbes. Later in such infections, the microbes or their molecules may escape into the cytoplasm, making it possible for Cytotoxic T lymphocyte responses to develop. Complement does not clear active intracellular ...
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'Port wine' coloured urine is not unusual following major electrical burns due to release of haemochromogens in to the blood stream from injured musculature.
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*Deletion or inactivation of RB gene by two mutations (knudson's two hit hypothesis) results in occurence of retinoblastoma. Ref: Khurana 7th/e p.314.
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Ans. is 'a', 'b' & 'c' i.e. Duodenal atresia, Duodenal stenosis and Volvulus
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A dendritic ulcer is a typical lesion of Herpetic keratitis. It is treated with topical acyclovir (not oral). Topical corticosteroids are contraindicated. Spontaneous healing does not occur.
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Adrenal adenoma on contrast-enhanced CT/MRI shows rapid uptake and relatively rapid washout of contrast material than do non adenomasQ. Adenoma: CT features Well defined/sharply defined  <5 cm in size Low attenuation (<10 HU) due to lipid content Mild homogenous enhancement Relatively rapid washout of contrast materia...
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Symblepharon: This is a condition where adhesion of the lid to the globe takes place. Any cause which produces raw surfaces on two opposed areas of the palpebral and bulbar conjunctiva will lead to adhesion if the areas are allowed to remain in contact during the process of healing, and thus allows cicatrization and fi...
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Ans. is 'b' i.e., Mast cells Type I hypersensitivity (Immediate hypersensitivity) o It is a rapidly developing immunological reaction occuring within minutes after the combination of an antigen with antibody bound to mast cells in individuals previously sensitized to the antigen. o Immediate hypersensitivity reactions ...
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Ans. Roger Haugen
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Lymphoreticular system include lymphoid & reticular components, with clearly demarcated function. The lymphoid cells lymphocytes & plasma cells are primarly concerned with specific immune response. The phagocytic cells, forming pa of the reticuloendothelial system are primarly concerned with the scavenger functions Ref...
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Dysthymia is chronic mild depression in which person have symptoms for more than 2 yrs. Ref: Essentials of postgraduate psychiatry By JN Vyas 1st ed Pg 604-607
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Ans. is 'd' i.e. Retinacular branches of circumflex femoral arteriesRef: Apley's 8th/e p 684; Adams 10th/e p 195; Maheshwari 3rd/e p 118Normally blood is supplied to the head of the femur by three routes-Intramedullary vessels in the femoral neckVessels in the ligament of head of the femur (ligamentum teres)Ascending c...
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Ans. C: Reduced side effects Advantages of Condoms Available on shelves without any medical prescription. Most harmless method of contraception. Best protection against sexually transmitted diseases and AIDS (HIV infection). Most suitable for couples having infrequent coitus, during lactation (breast-feeding), during h...
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A i.e. (Threatened abortion) (161 - 165 - Dutta 6th)THREATENED ABORTIONINEVITABLE ABORTIONINCOMPLETE ABORTION* Clinical entity where the process of abortion has started but has not progressed to a state from which recovery is impossible* Bleeding per vaginam is usally slight and bright red in colour. Bleeding stops spo...
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FISH IS: Richest source of Vitamin A and D is fish liver oils (especially Halibut fish). Rich source of proteins (15-25 percent). Rich source of Calcium, phosphorus, fluorides Good source of iron Poor source of carbohydrates & iodine (barring few sea fish).
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Ans is 'c' Peroxisomal defect Zellweger syndrome (cerebrohepatorenal syndrome)o It is one of three peroxisome biogenesis disorders which belong to the Zellweger spectrum of peroxisome biogenesis disorders (PBD-ZSD). The other two disorders are neonatal adrenoleukodystrophy (NALD), and infantile Refsum disease (3RD). Ze...
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Patients with K. pneumoniae infections usually have predisposing conditions such as alcoholism, advanced age, chronic respiratory disease, and diabetes Pulmonary infections can lead to necrosis and abscess formation Upper lobes of the lungs are predominantly affected The "currant-jelly" sputum distinguishes K. pneumoni...
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Ans. A. Cushing's syndromeOverproduction of ACTH leads to Cushing's syndrome. It is characterized by hyper-pigmentation and increased production of adrenocorticosteroid. These symptoms lead to negative nitrogen balance, impaired glucose tolerance, hypertension, edema, muscle atrophy etc.
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Ans. is 'a' i.e., G6PD deficiency
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Ans. is 'd i.e., More common in term baby During fetal life, most of the pulmonary aerial blood is shunted through the ductus aeriosus into the aoa . Functional closure of the ductus normally occurs soon after bih, but if the ductus remains patent when pulmonary vascular resistance falls, aoic blood is shunted into the...
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Ans. is 'b' i.e., Dexamethasone Coicosteroids should not be used' - Paediatrics for doctors - Frankshann & John Vince Management Protocol The management protocol of babies with asphyxia : Oxygen. In the absence of continuous oxygen saturation monitoring, it is reasonable to give nasopharyngeal oxygen (0.5 litre/min) un...
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Answer is A (Hyponatremia and urine sodium excretion > 20 meq/l) : Cardinal features of SIADH include: Hyponatremia (dilutional hyponatremia with Na+ < 135 mmol/1) Decreased plasma osmolality (150 m osm). Urine sodium over 20 meq/1 Low Blood urea Nitrogen < 10 mg/L Hypouricemia ( Clinical Euvolemia - Absence of sign of...
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Ans. is 'a' i.e., Wilm's tumor Wilms tumor o Wilms tumor is the most common primary renal tumor of childhood. o Usual age for diagnosis is 2-5 years. o Approximately 5% to 10% of Wilms tumors involve both kidney, either simultaneously or one after the other. o Nephrogenic rests are the precursor lesions of Wilms Tumor....
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Ans. is a i.e. Carcinoma Endometrium Pyometra is collection of pus or mixture of pus and blood within the uterus Causes : Most common cause 2"d most common cause : Other causes : Congenital atresia of the vagina/cervix. Stenosis of cervix / vagina following : - Operations - Burns Radiotherapy Endometritis : Senile Tube...
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.
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C i.e. Pronator qauadratus
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ANSWER: (C) Phospholipase CREF: Guyton s physiology 12th edition page 890, KDT 6th edition page no 46See APPENDIX- 84 below "ENDOCRINE GLANDS, HORMONES, AND THEIR FUNCTIONS AND STRUCTURE"Phospholipase C catalyzes the breakdown of some phospholipids in the cell membrane, especially phosphatidylinositol biphosphate (PIP2...
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Ans. is 'a' i.e., Left supraclavicular fossa o Virchow's node (or signal node) is a lymph node in the left supraclavicular fossa (the area above the left clavicle). It takes its supply from lymph vessels in the abdominal cavity. The finding of an enlarged, hard node (also referred to as Troisier's sign) has long been r...
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Ans. is c i.e. Simultaneous emptying of uterus and blood transfusion
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Ans. Reflection
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New damage may be initiated during reoxygenation by increased generation of ROS. Some of the ROS may be generated by injured cells with damaged mitochondria that cannot carry out the complete reduction of oxygen. Cellular anti-oxidant defense mechanisms may be compromised by ischemia, exacerbating the situation.  ROS g...
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ANSWER: (C) > 3 secondsREF: http://wwwunicef.org/india/FBC_Participants_Manual.pdfCapillary refill is a simple test that assesses how quickly blood returns to the skin after pressure is applied. It is carried out by applying pressure to the pink part of the nail bed of the thumb or big toe in a child and over the stern...
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Spermatozoa contain a tail for motility. The structure of the tail or composition of the tail is the axoneme which is composed of several internal structures. The structures are termed dynein outer arm, dynein inner arm, A tubule, B tubule, radial spoke, radial head, central tubule (middle of wheel) and a nexin link be...
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Given features (Female, primary amenorrhea, short stature, widely spaced nipples) suggests the diagnosis of Turner’s syndrome.   Turner’s Syndrome Turner’s syndrome is the most common sex chromosomal disorder in phenotypic females. Turner’s syndrome results from complete or partial loss of one X chromosome (45, XO) an...
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Ans. is 'a' i.e., Ballooning degeneration; 'b' i.e., Acidophilic inclusion (necrosis); `c' i.e., lnterphase hepatitis
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Rapacuronium has a rapid onset of action, minimal cardiovascular side effects, and a sho duration of action. It was withdrawn by the manufacturer following several repos of serious bronchospasm, including a few unexplained fatalities. Histamine release may have been a factor. Ref: Morgan, Jr. G.E., Mikhail M.S., Murray...
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An unusual form of cyst called botryoid odontogenic cyst, manifests radiographically with a multilocular pattern, is simply a polycystic variant of the lateral periodontal cyst developing through cystic transformation of multiple islands of dental lamina rests. The  botryoid odontogenic cyst appears similar, except tha...
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Ans. is a, i.e. Montevideo unitsRef Williams Obs, 23/e, p 4371 montevideo unit = Intensity of constraction x number of contractions in 10 mins.Montevideo unit is to define uterine activity.As per this:Clinical labour usually commences when uterine activity reaches values between 80-120 Montevideo units (This translates...
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Ans. is 'c' i.e., IgA IgAo It is the second most abundant antibody (after IgG).o It is major immunoglobulin in dost rum, saliva, tears, respiratory and gastrointestinal secretions. Ig A occurs in two forms.o Slg A and J chain are synthesized by plasma cells.o Secretory# component is produced by mucosal or glandular epi...
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It is impoant to remember that the medial circumflex femoral aery supplies blood to the femoral neck. During fractures of the femoral neck, this aery may be ruptured, and the femoral neck will be deprived of blood. The acetabular branch of the obturator aery provides blood to the acetabulum of the hip bone, which aicul...
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Ans. is 'a' i.e., Hemophilia A Hemophila A o Hemophilia A is due to deficiency offactor VIII. o Hemophilia A is inherited as an X-linked recessive trait. o Factor VIII is an intrinsic pathway component required for activation of factor X. o Clinical manifestations are due to defect in coagulation system : ? i) Large po...
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Aspirin is not a porphyrinogenic drug. There is a very exhaustive list of drugs given in the table from Harrison; I am giving some impoant drugs! Carbamezapine , chloramphenicol, clindamycin Dihydroergotamine , droperidol Hydralazine Fosphenytoin Indinavir Ketamine, ketoconazole Lidocaine Medroxyprogesterone , mifepris...
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Answer is A (Family history is present in 90% of cases): A strong family history (.90%) is a feature of type II DM and not type I DM. Family history may he present in only about 15% cases of type I DM.
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Hairy pinna points to the dignosis of infant of diabetic mother. Problems in infant of diabetic mother: Macrosomia- Difficult/ prolonged labour, | chances of bih trauma Metabolic- Hypoglycemia, hypocalcemia, polycythemia, hypomagnesemia Congenital hea defects- VSD, TGA CNS- neural tube defects, caudal regression syndro...
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. Myocardial infarction
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I trimester
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Antenatal Screening for Down's Syndrome USG - Nuchal Thickness > 3 mm 11 - 14 weeks of gestation - Absence of nasal bones - Sho femur - Duodenal Atresia Biochemical Tests 1st Trimester - b-HCG, PAPP-A (Pregnancy associated Plasma Protein - A) (Dual Test) 2nd Trimester QTriple Test - AFP (a-Fetoprotein) + b-hCG + Unconj...
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Symptoms of acute poisoning are similar to atropine poisoning hence atropine sulphate would aggravate the symptoms. All the other given options are used as treatment. REF: K D Tripathi 8TH ED.
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Ans. Detecting errors of refraction
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TypeConditionType ANormal tympanogramType AsCompliance is lower at or near ambient air pressure. Seen in fixation of ossicles, e.g. otosclerosis or malleus fixationType ADHigh compliance at or near ambient pressure.Seen in the ossicular discontinuity or thin and lax tympanic membraneType BA flat or dome-shaped graph. N...
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The main function of vitamin E is as a chain-breaking, free-radical-trapping antioxidant in cell membranes and plasma lipoproteins by reacting with the lipid peroxide radicals formed by peroxidation of polyunsaturated fatty acids.In experimental animals, vitamin E deficiency results in resorption of fetuses and testicu...
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Palmer's sign refers to the regular and rythmic uterine contractions which is elicited during bimanual examination. It is present as early as 4-8 weeks. Osiander's sign refers to the feeling of increased vaginal pulsation felt through the lateral fornices at 8th week of gestation. Jacquemier's sign or Chadwick's sign r...
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Ans. is 'a' i.e., Ludwig's angina o Ludwig's angina is a rapidly spreading bilateral cellulitis that involves the floor of mouth, under the tongue. Floor of mouth is comprised of sublingual space, submandibular space and submental space. Ludwig's angina usually begins in the submandibular space, and then rapidly spread...
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Ans. is 6b' i.e., 150 mlo In healthy individuals, physiological (total) dead space is equal to anatomica dead space, which is about 150 ml.Anatomical dead spaceo When air is breathed in, only the air that reaches the alveoli participates in gas exchange. The air in the airways (Trachea, bronchi) is breathed out unchang...
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