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Ans. is 'd' i.e., Patent ductus arteriosus Tetralogy of falloto TOF is the commonest cyanotic congenital heart disease.o It has four componentsi) VSDii) Pulmonic stenosisiii) Overriding or dextroposed aortaiv) Right ventricular hypertrophyo Pulmonic stenosis (right ventricular outflow obstruction) is mainly due to infu...
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Von Willebrand disease (VWD) is the most common inherited bleeding disorder. It is autosomal dominant, and its prevalence is estimated to be as high as 1 case per 1000 population.
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C i.e. Lower GI contrast study Lower GI contrast study confirms the diagnosis & indicate the type of involvement, in cases of lower intestinal obstruction causing failure to pass meconium timelyQ.
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Prospective study is the exposure to the risk factor and subsequent health outcomes are observed after the beginning of the study. Incidence can be calculated by this study. Ref: Park's Textbook of Preventive and Social medicine, 19th edition, Page 71, 74.
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Answer- D. Tension PneumothoraxEmergency thoracotomy is indicated after chest trauma in following conditions :Cardiac arrest (resuscitative thoractomy)Massive hemoththorax (>1500 mL of blood through the chest tube acutely or > 200-300 ml/hr after initial drainage.Penetrating injuries of the anterior aspect of the chest...
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Ans. is 'a' i.e., Squamous pa The pterion is situated in the floor of temporal fossa. It is an H-shaped suture, where four bones meet each other :? i) Greater wing of sphenoid ii) Squamous temporal iii) Frontal iv) Anterioinferior angle of parietal Central point of pterion is known as Syln point. the cranium is very th...
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D i.e. Antecubital fossa
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TYPES OF PRR Based on the extent and depth of the carious lesions: a) Type A - Suspicious pits and fissures where caries removal is limited to enamel. b) Type B - Incipient lesion in dentin that is small and confined. c) Type C - Characterized by the need for greater expIoratory preparation in dentin. Key concept Type ...
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Elevated E.S.R. * The jones criteria for rheumatic fever: Major criteria * CarditisQ . * Migratory polyahrrusQ Minor cieria Clinical * Fever * Sydenham's choreaQ * AhralgiaQ * Subcutaneous nodules Laboratory Erythema marginatumQ * Elevated acute phase reactants * Prolonged PR interval PLUS Suppoing evidence of a recent...
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Ans. is 'a' i.e., Pearl index
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Ans. is 'a' i.e., Imatinib and suntinib Molecular targeted agents Tyrosine kinase inhibitors Competitive inhibitors - Imatinib, Nilotinib, Sunitinib, Dasatinib, Erlotinib, Gefitinib, Lapitinib, Sorafinib (Remember all ends with ' nib'). Monoclonal antibodies - Cetuximab, panitumomab. HER2/neu (ERB B2) inhibitors Monocl...
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Fetischism
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Ans. is 'd' i.e., Secondary hyperparathyroidism with chief cell adenoma o Davidson states "In very small propoion of cases of secondary hyperparathyroidism continuous stimulation of the parathyroid may result in adenoma formation and autonomous PTH secretion. This is known as teiary hyperparathyroidism".
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Answer- C. Hyperventilation provokes absence seizuresTypical absence seizures are characterized by sudden, brief lapses of consciousness without loss of postural control.The seizure typically lasts for only seconds, consciousness returns as suddenly as it was lost, and there is no post ictal confusion.Typical absence s...
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Predisposing factors for candidiasis are diabetes, malignancy, immunodeficiency, prolonged administration of antibiotics, patients on immunosuppressive drugs and intravenous catheters. Use of OCP causes elevation of blood glucose level by causing carbohydrate intolerance which in turn causes diabetes. Ref: Textbook of ...
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The abnormal posture is likely to be muscular dystonia. Metoclopramide can result in dystonias due to its D2 receptor blocking propey in the CNS. Domperidone also blocks D2 receptors but does not cross the blood brain barrier.
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Ans. D: All of the above Typhoid fever is caused by Salmonella typhi. Paratyphoid fever is caused by Salmonella paratyphi A, B and C. The term enteric fever encompasses both typhoid and paratyphoid fevers.
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p53 is the protein produced by TP53, guardian of human genome. It stimulates cells for DNA repair and in anti onco genic.Basic Pathology, Robbins. Page no.:185
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Ans. is 'a' i.e., Metyrapone Drug metabolizing enzymes The drug metabolizing enzymes are divided into two types : Microsomal These are located on smooth endoplasmic reticulum primarily in liver, also in kidney, intestinal mucosa and lungs. Examples are monooxygenase, cytochrome P450, glucronyl transferase. They catalyz...
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All varieties of visual hallucination are found in acute organic states but small animals and insects are most often hallucinated in delirium. Reference: Fish's Clinical Psychopathology, page 23.
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10 ATPs are generated per 1 pyruvate molecule. 1 Glucose yields 2 pyruvate molecules.
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Onychomycosis is a fungal infection of nails MC site for onychomycosis: hyponychium Types 1. Distal lat.subungual onychomycosis- MC 2. Proximal subungual onychomycosis (rare)-In HIV+ patient 3. Superficial white onychomycosis4. Total dystrophic onychomycosis- it is the end result of either of the types. It is complete ...
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Nerves related to kidneys posteriorly are: Subcostal (T12), iliohypogastric (L1), and ilioinguinal (L1). Four muscles are in posterior relations of kidney: Diaphragm, quadratus lumborum, psoas major, and transversus abdominis. fig:- posterior relation of kidney
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Ans. (d) Cerebral malaria(Ref: Malaria - Page 76)In malignant cerebral malaria caused by Plasmodium falciparum, brain vessels are plugged with parasitized red cells, causing ring hemorrhage which is accompanied by necrosis of surrounding parenchyma.The damage leads to formation of Durck's granuloma - collection of micr...
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(Shock lung): (2205-HI8th edition; 189-CSTD 13th)Contusion of the lung - used to indicate the consequences of the blunt trauma to the lung. It often occurs in rapid deceleration of the chest against an automobile steering wheel or fall from a height or in blast injuries.An associated lung contusion may produce a decrea...
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Cylindroma A malignant epithelial tumour also known as Turban tumor Known as cylindroma because of histological appearance
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Sensations carried by the posterior column -        Proprioception, Vibration, kinesthesia, fine touch. Sensations carried by the anterolateral column -        Temperature, pain (lateral) and crude touch (anterior) Crossing over of fibers occurs in case of the anterolateral system.
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The metabolic pathway of catecholamines is initiated by conversion of tyrosine to dopa, which in turn, forms dopamine. Dopamine forms norepinephrine, which is the precursor of epinephrine. Epinephrine is the main amine secreted during life and is concerned with the "fight or flight" reaction.
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Ximelgatran is an oral direct thrombin inhibitor. All the other given drugs are parenterally acting direct thrombin inhibitor. From medical pharmacology padmaja 4th edition Page no 334
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question repeated
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Step 1: Uptake and Phosphorylation of Glucose Glucose is phosphorylated to form glucose-6-phosphate. The reaction is catalysed by the specific enzyme glucokinase in liver cells and by non-specific enzyme hexokinase in liver and extrahepatic tissue. The enzyme splits the ATP into ADP, and the Pi is added to the glucose....
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Model For End-Stage Liver Disease (MELD) for Ages 12 and Older * The Model for End Stage Liver Disease (MELD) predicts survival for patients with advanced liver disease. * The United Network for Organ Sharing (UNOS) made a policy change regarding a revision in the MELD scoring system on January 11, 2016 that is related...
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Ans. Barium swallow right anterior oblique view
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C i.e. Bone marrow in femur
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(A) Spinocerebellar ataxia # Vitamin E deficiency causes Ataxic neuropathy due to loss of proprioception & myopathy with proximal weakness.
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- Papilledema is usually not seen in infancy & neonates, as the fontanelle are open. - Signs & symptoms of raised ICP: Headache, vomiting, visual disturbances, progressing to neurological deficits & coma Chronically raised ICP before closure of sutures results in increased head size & hydrocephalus presenting as Bilate...
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The thin filaments are made up of actin, tropomyosin, and troponin. Thick filaments are made up ofmyosin.(REF: GANONG'S REVIEW OF MEDICAL PHYSIOLOGY -23rd EDITION. Page No-95)
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Ans. (A) 5HT1A(Ref: Goodman and Gilman 13th/234)Drugs acting on serotonergic receptors 5-hydroxytryptamine (serotonin) is synthesized from tryptophan. It acts by activation of several serotonin receptors (5-HT1 to HT7).5-HT1A (presynaptic receptor) modulates the release of serotonin. Partial agonists of this receptor (...
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Ans. is 'c' i.e., Infectious and parasitic diseases The ICD-10 is arranged in 21 major chaptors.21 Chapters and their contentsChapter I includes 'Infectious and parasitic diseases'Chapter II includes Weoplams'Chapter III includes 'Diseases of blood & immune system'Chapter IV includes 'Endocrine, nutritional and metabol...
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Most cases of tuberculosis are caused when patients inhale droplet nuclei containing infectious organisms. While the bacilli are deposited on the alveolar spaces, they do not clog up the alveoli but are engulfed by macrophages. Tissue injury is not a result of toxin secretion but by cell-mediated hypersensitivity, that...
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In Boerhaave's syndrome, vomiting occurs against a closed glottis and pressure builds up in the oesophagus. The pressure in the oesophagus increases rapidly, and the oesophagus bursts at its weakest point in the lower third, sending a stream of material into the mediastinum and often the pleural cavity as well. In Mall...
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Child is presenting with mouth breathing. Palate is high arched.There is nasal obstruction and recurrent respiratory tract infections along with hearing impairment. All these features are suggestive of adenoid hyperplasia. In case of adenoid hyperplasia, impairment of hearing is due to secretory otitis. Thus the logica...
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Ans. C. B-DNA(Ref: Harper 31/e page 340)Physiologically most common is B-DNA.QUnder low salt and high degree of hydration B DNA is usually foundUnder high salt concentration and low degree of hydration A-DNA is usually found.The distance spanned by one turn of B-DNA is 3.4nm (34Adeg)The width of the double helix in B-D...
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Ans. is 'a' i.e., Haematuriao Painless Hematuria is the most common presenting symptom. It may be gross or microscopic, intermittent rather than continuous.Symptoms of vesical irratibility are second most common --> Frequency, urgency, dysuria.Pain may occur rarely due to secondary clot retention, tumor extension into ...
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Vasopressin is often called the antidiuretic hormone (ADH). It increases the permeability of the collecting ducts of the kidney, so that water enters the hypeonic interstitium of the renal pyramids. The urine becomes concentrated, and its volume decreases. The overall effect is, therefore, retention of water in excess ...
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Verpamil (CCB) does not cause hyperglycemia at therapeutic doses required for the management of Angina. CCB cause A-V block so causes || PR interval and bradycardia in the patients. Other side effects of CCB are:- Constipation(more common with Verapamil) Peripheral edema
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Ans. is 'c' i.e., isoleucine
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.Groin flap: It is based on superficial circumflex iliac aery which is 2-3 cm below and parallel to the inguinal ligament. Aery originates from femoral aery over medial border of the saorius and ends at anterior superior iliac spine. 1:1 rectangular flap with deep fascia is used. Secondary defect can usually be closed ...
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Congenital synkinetic ptosis (Marcus Gunn jaw winking ptosis). In this condition there occurs retraction of the ptotic lid with jaw movements i.e., with stimulation of ipsilateral pterygoid muscle. It is due to the mixing of the fibres of 5th and 3rd cranial nerves. Ref:AK Khurana 4thE pg356
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Lamivudine (3TC) :This deoxycytidine analogue IS phosphorylated intracellularly and inhibits HIV reverse transcriptase as well as hepatitis B virus (HBV) DNA polymerase. Zidovudine: It is a thymidine analogue (azidothymidine, AZT), the prototype NI. After phosphorylation in the host cell-zidovudine triphosphate selecti...
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Palatal paralysis is a cause of Rhinolalia Apea (Hypernasality) and not Rhinolilia Clausa (Hyponasality). Rhinolalia Apea (Hypernasality or hyperrhinolalia or open nasality) is defined as excess resonance of vowels and voiced consonants within the nasal cavities. The anatomic-physiologic basis is open coupling between ...
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Answer is D (Carbamazepine) : Carbamazepine is the most effective drug for complex paial seizures and shares first choice drug status with phenytoin for generalized tonic clonic seizures and simple paial seizures. It is however not indicated in status epilepticus. Anticonvulsant therapy therapy for status epilepticus :...
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Ans. (d) Severe bacterial infection(Ref Gut liver 2010, 4 (3): 338-344)Uveitis and polyarthritis are common extra intestinal manifestation of crohn's disease.Sacroiliitis is more common in crohn's disease (21%) as compared to U.C (12.2%) especially in patients with upper CaI or personal involvement.Pre cholangitis is c...
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Ans. is 'a' i.e.. Ulnar artery [Ref: Schwartz 9th/e p. 636; Sabiston 18th/e p. 1813; o Allen's test is used to assess collateral circulation in hand. In Allen's test, the radial artery is occluded by pressure over it at the wrist, for several minutes and the color of hand is compared with other hand. This is the first ...
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Deep palmar arch is formed mainly by terminal pa of the radial aery and is completed medially at the base of fifth metacarpal bone by the deep palmar branch of the ulnar aery. Superficial palmar branch of radial aery joins with the ulnar aery laterally to form a superficial palmar arch which supplies the digits. Deep p...
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- complement is a complex of nine different fractions, C1 to C9. - they are synthesised at various sites in the body. - the complement C3, C6, C9 are synthesised in liver. Reference : Anathanarayan & paniker's 9th edition, pg no:126 <\p>
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Recombinant IL-2 (aldesleukin) is used for the treatment of malignant melanoma and renal cell carcinoma.
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[Cl (Seropuralent discharge from the part of tubes) (419-S) (166-Gynae -Dutta 5th)Acute salpingitis, the fallopian tube is swollen, oedematous, and hyperaemic with visible dilated vessels on the peritoneal surface. Some degree of serous exudation is seen around the fallopian tubes.* The sure sign of salpingitis is the ...
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maternal ti child trnsmisdion is prevented by nevirapine REF:TEXT BOOK OF DERMATOLOGY IADVL'S TEXT BOOK PAGE.159 MCQ
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Ans. (d) AvidinRef.-.Nelson 18th ed., Chapter 42* Human milk contains a variety of cells, including macrophages, T cells, stem cells, and lymphocytes.* In early lactation, the breastfed infant may consume as many as 1010 maternal leukocytes per day.* About 80% of the cells in early milk are breast milk macrophages, whi...
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Single positive blood culture positive for coxiella burnetti is one of the criteria for diagnosis of Infective endocarditis.
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TIGAR-O Classification of Etiology of Chronic Pancreatitis * T - Toxic - Metabolic I - Idiopathic G - Genetic A - Auto Immune R - Recurrent severe O - Obstructive
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CRUCIATE LIGAMENTS: Very thick and strong fibrous bands. Direct bonds of union between tibia and fibula. Maintain anteroposterior stability of knee joint. Anterior cruciate ligament:- Begins from anterior pa of intercondylar area of tibia, runs upward, backward and laterally and is attached to the posterior pa of media...
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Ans. is 'a' i.e., ATN; 'b' i.e., Pulmonary Congestion; 'c' i.e., Depletion of lipid in adrenal coex Morphological changes in shock o The cellular and tissue changes induced by shock are essentially of those of hypoxic injury as final pathway in all types of shock is reduced tissue perfusion and decreased oxygen supply....
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Temper tantrum reaches its peak point during second and third year of life and gradually subsides in between 3 to 6 years as the child learng to control his negativism and complies to the requests of others.
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In constitutional growth delay, IGF-1 levels tend to be low for chronological age but within the normal range for bone age. Birth weight and height are normal. Bone age is less than chronological age.
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The stipple sign refers to tracking of contrast into the interstices of a papillary lesion. This is seen in Intravenous urography (intravenous pyelography) of transitional cell carcinoma of renal collecting sysym. Other signs on IVP are filling defect; Calyceal obliteration & amputation; hydronephrosis with soap bubble...
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*acute graft versus host disease occurs within days to weeks after allogenic bone marrow transplantation.Reference;Robbins and Cotran pathologic basis of disease South Asia edition.
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The hallmark of bone conduction thresholds in otosclerosis/otospongiosis is the Carha notch. This is characterized by the elevation of bone conduction thresholds of approximately 5, 10, and 15 dB at 500, 1000, and 2000 Hz, respectively. The Carha notch is thought to result from the disruption of normal ossicular resona...
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Women in the question stem with altered sensorium and dehydration is suffering from ketoacidosis. Absence of sugar exclude the diagnosis of diabetic ketoacidosis. So ketosis could be due to starvation which can be detected by Rotheras test. During starvation acetylCoA takes alternate fate to form ketone bodies. Ref: Te...
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Logo given question is of Radiation Hazard:- Central circles of radius R, an internal radius of 1.5R and an external radius of 5R for the blades, which are separated from each other by 60 degree. Trefoil is black in the international version. Commonly referred to as a Radioactivity warning sign, but it is actually a wa...
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Encephalopathy precipitating events:HypokalemiaInfectionIncreased dietary protein load Electrolyte disturbancesRef: Harrison's; 18/e; p2601
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Risk factors of recurrence of simple and complex febrile seizures are : 1. Early age of onset ( less than 15 months ) 2. Epilepsy or fevers in 1st degree relatives 3. Frequent fevers and low temperature at the Onset of febrile seizure -The risk of developing epilepsy is higher if the seizure are atypical , EEG is persi...
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Moebius syndrome results from the underdevelopment of the VI and VII cranial nerves. It is characterized by facial paralysis and there is inability to move the eyes from side to side. Most people with this syndrome are born with complete facial paralysis and cannot close their eyes or form facial expressions. There is ...
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Ans. is 'd' i.e., Third metacarpal All metacarpals (except first) have Distal (head) epiphysis.First metacarpal and all phalanges have - Proximal (base) epiphysis.Thus, 1' metacarpal resembles phalanges more than other metacarpals.
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Ans ie 'a' ie Extradural haemorrhage (Ref. : Chapman, 3/e, p438)CT scan (non-contrast) is the best diagnostic method to evaluate a head injury pt. (better than MRI)On CT scan -Extradural haemorrhage appears as biconvex lentiform opacity. *Subdural haemorrhage appears as concavoconvex crescentic opacity. *Intracerebral ...
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Ans. is 'c' i.e., Across ora serrata Attachement of vitreous Vitreous is attached anteriorly to the lens (Hyloid capsular ligament of Wieger) and ciliary epithelium in front of the ora serrata. The pa of vitreous about 4 mm across the ora serrata is known as the "base of vitreous" where the attachement is strongest Pos...
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Ans. is a, b, and c i.e. GnRH analogues; Danazol; and Mifeprestone As I have already explained in previous question, the drugs used to decrease blood loss / vascularity of fibroid during surgery are :
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Rheumatoid factor: Antibodies in rheumatoid disease, especially the IgM, can be demonstrated by the Rose Waaler test, latex fixation test or bentonite flocculation. Rheumatoid factor is positive in 80% of adults with rheumatoid ahritis. A differential agglutination titer of16 and above is diagnostic of rheumatoid ahrit...
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Fluoride
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Brain is the first organ to putrefy amongst the options provided. Putrefaction Review: Putrefaction is disintegration of body tissues after death produced by the action of bacteria and other microorganism thriving on the body. It represents the last stage in resolution of body from the inorganic to organic state. Putre...
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Ans. is 'c' i.e. proteolytic enzymes secreted in inactive form The pancreatic enzymes have the capability of digesting the pancreas itself (mainly proteases)(Auto digestion of pancreas is considered to be the main pathogenic mechanism for pancreatitis)Normally, auto digestion of pancreas is prevented by several means :...
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Most common cardiac anomoly associated with Turner's syndrome is Bicuspid Aortic valve > Coarctation of Aorta.
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Ans. is 'c' i.e., Lymphatics o "It is the in flammatory reaction in the arterial wall with involvement of the neighbouring vein and nerve ".o "Occlusive lesions are predominate seen in muscular arteries".
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H/O systemic sclerosis with shoness of breath and CXR findings are suggestive ofInterstitial lung disease(ILD). Investigation Of Choice for ILD is HRCT ILD is the most common pulmonary manifestatation of systemic sclerosis It occurs in about half of patients with diffuse disease and in about 1/3rd cases with limited di...
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Radiotherapy is the treatment of cancer with ionizing radiation. It works by damaging the DNA within the tumor cells, making them unable to divide and grow. The goal of radiation therapy is to maximize the dose to tumor cells while minimizing exposure to normal, healthy cells. Ref: Emami B et al. 1991
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C i.e. Referred to as paradoxical sleep
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Atropine has a very long duration of action in the eye while shorter action in other organs.
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The threshold for prophylactic platelet transfusion is 10,000/mL. For invasive procedures, the target level is 50,000/mL. Note: Shelf life of donor platelets is 5 days.It is stored on a special agitator at 20-24 degC. The half-life of transfused platelets is 3-5 days. One unit of pooled platelets should be infused over...
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The stomach's acidity keeps the number of microorganisms at a minimum (102-103/mL of contents). In the adult duodenum, there are 103-104 bacteria/mL of effluent; with higher populations in the jejunum, 104-105 bacteria/mL, and ileum, 108 bacteria/mL; and in the cecum and transverse colon, 1011 bacteria/mL. In the sigmo...
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Ans. is 'c' i.e., MacrophagesAcute inflammatory reaction with a predominance of Neutrophils is seen upto 2-3 days.After 3 days (i.e. after 72 hours), Macrophages become the predominant cell type and become involved in removal of necrotic debris.
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The first change in precancerous lesion is punctuation
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HSP is characterized by tetrad of palpable purpura, arthritis, glomerulonephritis and abdominal pain. Less common skin lesions are : nonpalpable macules & patches, urticaria, bullous lesions, vesicles, splinter hemorrhage and ulcerations. Rarely epistaxis may occur.
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The first stage of sleep is characterized by theta waves, which are even slower in frequency and greater in amplitude than alpha waves. The difference between relaxation and stage 1 sleep is gradual and subtle. A person falling asleep first enters stage 1, the EEG begins to show a low-voltage, mixed-frequency pattern. ...
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Clozapine causes weight gain, not weight loss. Agranulocytosis and Myocarditis are does independent side effects. Seizures are dose dependent side effect seen with Clozapine.
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CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc) is a multisystem connective tissue disorder. The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. It is associated with detectable antibodi...
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The mycoplasmas are cell wall-lacking bacteria that do not synthesize the precursors of peptidoglycan. A unique characteristic is that some genera require cholesterol for growth; unesterified cholesterol is a unique component of the membranes of both sterol-requiring and non-sterol-requiring species if present in the m...
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Ans. D: Opsonization Phagocytosis is largely responsible for depletion of cells coated with antibodies Cells opsonized by the IgG antibodies are recognized by phagocyte Fc receptors, which are specific for the Fc poions of some IgG subclasses Agglutination When a paiculate antigen is mixed with its antibody in the pres...
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Ans. is 'a' i.e., Hyperkalemia Effect of svmpathomimetics on plasma potassium. o The biochemical pump that shifts potassium into cells is activated by the f32-adrenoreceptor agonists. o So [3,-agonists cause hypokalemia. o The hypokalemia effects of 132-agonists may be clinically impoant, paicularly in patients having ...
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Clavipectoral fascia forms the anterior wall of the axilla.Also know:Boundaries of Axilla:Anterior wall: Pectoralis major, Pectoralis minor, Clavipectoral fasciaPosterior Wall: Subscapularis, Teres major, Latissimus dorsiMedial Wall: First rib and their associated intercostals muscles, Serratus anteriorLateral Wall: In...
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