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Ans. c (Pellagra). (Ref to Q.10 of MH 2001)Animal foods, such as milk, eggs, and meat, have high biologic value as most of the needed amino acids are present in adequate amounts. Plant proteins corn/maize (maize is deficient inlysine and tryptophan), soya (soya is deficient methionine), and wheat (wheat is deficient in...
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Catatonia most commonly seen with Depression than Schizophrenia.
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Ans. b (Herpes genitalis)TORCH group of infections are the most vital and morbidity and mortality causing intrauterine infections.Herpes amongst these is common cause of fetal loss.
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Answer is C (Desferroxamine is the treatment of choice): The therapy of hematochromatosis involves removal of excess body iron Iron removal is best acieved by periodic phlebotomies which is the treatment of choice for Hematochromosis. Chelating agents like desferoxamine are less effective and indicated when anemia or h...
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Metropathia haemorrhagica or cystic glandular hyperplasia or Schroeder's disease is a type of abnormal bleeding, usually met in premenopausal women. The basic pathology may lie in the ovaries or may be due to disturbance of the rhythmic secretion of the gonadotrophins. There is slow increase in secretion of estrogen bu...
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Dying declaration It is a written or oral statement of a person, who is going to die as a result of some unlawful act, relating to the cause and circumstances of his death. Made to Judicial Magistrate Or Medical officer Oath is not needed Not in the presence of accused. Cross examination not permitted Practiced in Indi...
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Necrosis: Type of cell death associated with loss of membrane integrity and leakage of cellular contents culminating in the dissolution of cells, largely resulting from the degradative action of enzymes on lethally injured cells. The enzymes responsible for digestion of cells may be derived from the lysosomes of the dy...
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Hypokalemia Hypokalemia is defined as serum potassium values of less than 3.5 meq/L.
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In first order/exponential kinetics: Rate of elimination is propoional to the plasma drug concentration Clearence and tl/2 remains constant Constant fraction of the drug is eliminated in unit time Most of the drugs follow first order kinetics Zero order/linear kinetics Rate of elimination remains constant irrespective ...
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A. No long-term effect(Ref: Nelson's 20/e p 876-880, Ghai 8/e p 327-329)Kernicterus is due to deposition of conjugated bilirubin in basal ganglia.Mnemonic for features of Chronic Bilirubin Encephalopathy (Kernicterius): "S-A-D M-U-M"
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The protein skeleton consists of 2D mesh of spectrin tetramers and oligomers. It is attached to RBC membrane by attaching to ankyrin. Membrane proteins like glycophorin also present. Ref: Textbook of medical physiology by N Geetha, 3rd edition, page no. 77
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Erythema nodosum * Erythema nodosum produces debilitating cutaneous symptoms indicative of a variety of underlying pathophysiologic processes. * The condition can develop in a patient with acute disease or one who is asymptomatic, and onset is sudden. * Symptoms include fever, chills, malaise, and ahralgia. Leukocytosi...
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Vecuronium, a non-depolarizing blocker, acts on nicotinic receptors at myoneural junction.
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In Lactose intolerance, there is a deficiency of the enzyme lactaseSo there is no natural breakdown of lactose - a carbohydrate present in milkThis causes diarrheaThe stool contains reducing sugar which causes perianal excoriation(Refer: Nelson's Textbook of Pediatrics, SAE, 1st edition, pg no. 1876)
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Estimation of chlorine demand of water (or dose of bleaching powder required for disinfection of water) is done by 'Horrock's apparatus'. Chlorine demand of water: is the amount of chlorine that is needed to destroy bacteria and to oxidize all the organic matter and ammoniacal substances present in water. Is the amount...
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Hypocalcemia: The most significant sign is intermittent QT prolongation, or intermittent prolongation of the QTc (corrected QT interval) secondary to a lengthened ST segment and depressed ST segment. Although rare, this may lead to arrhythmias such as torsades de pointes, VT, or complete hea block. Ref : Harrison 20th ...
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Ans: D (Hepatic encephalopathy.) Ref: Davidson 21st edn and Harrison's Principles of Internal Medicine, 18th ednExplanation:HEPATIC ENCEPHALOPATHYIt is a neuropsychiatric syndrome caused by chronic liver disease.Due to disturbance of brain function by circulating neurotoxins metabolised by liver.Neurotoxins include:o A...
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Mass in bronchus in an old chronic smoker suggest bronchogenic carcinoma. The marker of carcinoma, on immunohistochemistry, is cytokeratin. Other epithelial markers for carcinoma are :- Epithelial membrane antigen (EMA):- Breast, lung and Kidney's adenocarcinoma. Carcino-embryonic antigen: - Carcinomas of GIT, pancre...
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CSOM is notorious for intracranial complications. The first priority in mastoid surgery is given to free drainage of pus to render the ear safe. Second priority is given to preserve or reconstruct hearing mechanism.
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The disease is adenocarcinoma of the colon. Predisposing conditions include inflammatory bowel disease (ulcerative colitis more than Crohn's disease) and adenomatous polyps occurring either as an isolated finding or as pa of familial syndromes including familial polyposis coli, Gardner syndrome, and Turcot syndrome. We...
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The major causes of neonatal moality are prematurity/low bihweight (LBW) and congenital anomalies.Moality is highest during the 1st 24 hr after bih.Neonatal moality accounts for about two-thirds of all infant deaths (deaths before 1 yr of age).(Refer: Nelson, Chapter 93; pg no. 789)
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IgG antibodies are generated following class switching and maturation of the antibody response and thus paicipate predominantly in the secondary immune response Ref: Ananthanarayan & Panikers textbook of microbiology 9th edition pg:97
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Modified Milwaukee classification is used for Biliary sphincter of oddi classification Types Sphincter of oddi stenosis : Also known as papillitis Benign intrinsic obstruction of the CBD outlet. Sphincter of oddi dyskinesis : It is an intermittent functional Blockage of the high pressure zone of the sphincter. Basal pr...
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Ans is d i.e. All of the above
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Neutrophils can provide clues to a variety of conditions. Vacuolated neutrophils may be a sign of bacterial sepsis. The presence of 1- to 2-mm blue cytoplasmic inclusions, called Dohle bodies, can reflect infections, burns, or other inflammatory states. If the neutrophil granules are larger than normal and stain a dark...
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Ans. (a)For proteins and erythrocytes - T cell dependent antigens.For polysaccharides - T cell independent antigens.Protein antigens eliminated in days to weeks whereas polysaccharide antigens persist for months to years e.g., pneumococcal polysaccharide may persist upto 20 years in humans following a single injection.
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1. Ketanserin It has selective 5-HT2 receptor blocking propey with negligible action on 5-HT1, 5-HT3 and 5 HT4 receptors and no paial agonistic activity. 2. Methysergide is a potent 5-HT2A antagonist, nonselective-acts on S-HT1 receptors. It is used for migraine prophylaxis, carcinoid, and postgastrectomy dumping syndr...
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Ans. (a) Papillary cancerRef: Page 765. Bailey and love 26th edition* Lateral aberrant thyroid is a metastatic node from papillary cancer which is not palpable
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Obesity is qualitative variable ; breast cancer also qualitative. So, appropriate statistical test to find out obesity as a significant risk factor for breast cancer is Chi-square test.
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Chloroquine is the treatment of choice for malaria caused by all sensitive Plasmodium species. For the woman with chloroquine-resistant infection, which constitutes the majority of falciparum infections, quinine plus clindamycin is currently recommended. Quinine may induce hyperinsulinemia and thus, possible maternal a...
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Systemic coicosteroids are not teratogenic and they are the recommended treatment of choice for pustular psoriasis in a pregnant woman. Ref: Obstetric Dermatology: A Practical Guide By Arieh Ingber, Chapter 13, Page 135
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The membrane of the zymogen granule fuses with the apical cell membrane to release the proenzymes synthesized by the pancreatic acinar cells into the acinar lumen. This is exocytosis. Transcytosis describes the transit through the cytoplasm of ceain materials, such as immunoglobulin A, from one surface of a cell to ano...
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The crossing of the uterine vessels and ureter is at the level of internal os. Over here the ureter runs below the uterine vessels (water below the bridge) and the distance between the ureter and uterine vessels is only 1.5–2 cm. The ureter can get injured at all the sites mentioned in the question but during gynaecolo...
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(d) Loss of consciousness(Ref. Scott Brown, 8th ed., Vol 2, 819)The patient is fully conscious and oriented during an attack of Meniere.Meniere being a disturbance of peripheral vestibular system is therefore not characterised by any focal (such as diplopia, dysarthria, paresthesia, etc.) or generalised neurological sy...
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Ans. is 'd' i.e., Veebrae Haemangioma This benign lesion, probably a hemaoma, is composed of vascular spaces lined by endothelial cells. They constitute 1-1.5% of all primary bone neoplasms. It has a peak incidence in the fifth decade (according to Maheshwari, young adults). About 50% of hemangiomas of bone occur in ve...
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Accelerated Rural Water Supply programme was launched in 1972-73. Rajiv Gandhi National Drinking water mission was staed in1991-92. It was later scaled up to Swajaldhara in 2002. Ref: Health policies and programmes in India, D.K. Taneja 11th edition page: 397
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Ans. is 'a' i.e., Listeria monocytogenes L. monocytogenes is a short, gram positive, non-spore forming rod. The motility test rapidly differentiates listeria from diphtheroids that are members of the normal microbiota of the skin. The organism has several adhesion proteins (Ami, Fbp A, and flagellin proteins) that faci...
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Ans. (c) Production of vitamin KRef: Robbin's pathology 9th ed. Z821* Vitamin K is produced by the bacteria of gut and is used by liver for gamma carboxylation of factor 2/7/9/10.# Liver produces albumin which falls in liver cirrhosis producing ascites/edema.# Ammonia is combined with carbon dioxide to produce urea whi...
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Ans. is 'b' i.e., Leucine o Branched-chain amino acids are leucine, Isoleucine, and Valine. Leucine is purely ketogenic. Isoleucine is both ketogenic and glucogenic. Valine is glucogenic.
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Ans DIn pectus excavatum the heart is shifted towards left side. As right heart border goes behind the sternum it is obscured and can thus mimic right middle lobe disease.
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Contraindication of centchroman "are" PCOS. Cervical hyperplasia.
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Deep vein thrombosis Deep vein thrombosis (DVT) is a well-known and, when complicated by pulmonary embolus, potentially fatal complication of surgery. All hospitals must have a pro cess for screening all surgical patients to identify those at risk and for implementing prophylactic measures. There is inter- national agr...
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Ans. Hysterical amblyopia
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Cowper
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Ans. is `c' i.e., Pseudomonas Pseudomonas aeruginosa . Morphology - Gram negative bacilli - Motile by polar flagellum - Non capsulated but many strains have mucoid slim layer especially the organisms which are isolated from cystic fibrosis patient. . Culture - Obligate aerobe - Colonies emit a distinctive, musty, mawki...
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Ans. is 'C' i.e., DIEP flap
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.Hamaomatous polyps are seen in * Peutz-Jegher's syndrome. * Juvenile polyp. * Cronkhite - Canada syndrome. Juvenile Polyps * Commonest polyp of colorectum in infants and children. * Can cause intussusception, prolapse through rectum, bleeding. Cronkite - Canada Syndrome * Polyps in stomach, duodenum and colorectum. No...
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Ans. is 'c' i.e., 2 Light chains, 2 Heavy Chains
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* Factors affecting the height of block :- -- Volume of drug -- Baricity (Ratio of specific gravity of an agent to that of CSF). -- Position of the patient -- Intra-abdominal pressure -- Curvature of spine * Factors affecting duration of block :- -- Dose -- Concentration - - Drug (LA used) -- Added vasoconstrictors
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Insulin
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Ans. is 'c' i.e., Acute intermittent porphyriaType of PorphyriaNeuropsychiatric symptomsSkin symptoms/PhototoxicityA. Hepatic porphyrias1) Acute intermittent porphyria2) 5-ALA dehydratase deficiency3) Hereditary coproporphyria4) Variegate porphyria5) Porphyria cutanea tarda++++---+++B. Erythropoietic porphyrias1) Eryth...
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Ref. The Short Textbook of Pediatrics. Pg 550   Anterior fontanelle closes  around 10-18 months Posterior fontanelle closes around 8 weeks Persistent posterior fontanelles is earliest sign of hypothyroidism
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Chalky white disc is seen in primary optic atrophy. Trauma to optic nerve, Tabes dorsalis (syphilis), and Leber's hereditary neuritis can cause primary optic atrophy. In post papilledematous (Secondary) optic atrophy the disc is pale or dirty/ grey disc.
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Diseases under WHO surveillance  Polio Rabies Relapsing fever Influenza Salmonellosis  Malaria Louse born typhus
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Energy expenditure in resting state is almost equal to Basal metabolic rate i.e. the minimum energy expenditure for the body to exist. Basal metabolic rate is related to both Body surface area and Lean body mass. However it appears to be more closely related to Lean body mass. Lean body mass is the total mass of the bo...
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Vitamin A deficiency and Keratomalacia The condition is usually bilateral. The cornea becomes dull and insensitive, hazy, and yellow infiltrates form until finally the whole tissue undergoes necrosis and seems to melt away (Keratomalacia) with in few hrs. A characterstic feature is the absence of inflammatory reaction....
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(Refer: AK Khurana Comprehensive Ophthalmology, 6th edition, pg no.63 - 65) Methyl alcohol is metabolized very slowly and thus stays for a longer period in the bodyIt is oxidized into formic acid and formaldehyde in the tissues. These toxic agents cause edema followed by degeneration of the ganglion cells of the retina...
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Ans. is 'c' i.e., Posterior subcapsular o Corticosteroid induced cataract is posterior subcapsular cataract.Types of CataractCausesPosterior subcapsularMyotoic dystrophy, Wilson's disease, DM, Atopic dermatitis, Down's syndrome, Corticosteroids, Busulfan, Chloroquine, Trauma, Ionizing radiation , Galactosemia, Senile c...
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Sensitivity
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Ref. Grainger and Allison's Diagnostic Radiology. Page. 30   Bragg Peak The Bragg peak is a pronounced peak on the Bragg curve which plots the energy loss of ionizing radiation during its travel through matter. For protons, α-rays, and other ion rays, the peak occurs immediately before the particles come to rest
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The mid-year population is considered. Hence July 1st is taken.
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Ans. is 'b' i.e., Endoplasmic reticulum Remember that all the proteins are synthesized on ribosomes.Ribosomes are of two types * Free ribosomes (in cytoplasm) * Ribosomes attached to endoplasmic reticulumProtein synthesis takes place both in free ribosomes located in cytoplasm and ribosomes attached to endoplasmic reti...
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Ans. is 'c' Hepatic disease Digoxin toxicity is enhanced by renal failure as it is excreted through kidneys where as digitoxin toxicity is enhanced by liver failure because it is eliminated by hepatic metabolism.Other factors precipitating Digitalis toxicityAdvanced ageAcute myocardial infarction or ischemiaHypoxemiaHy...
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Satellite lesions → Borderline tuberculoid Punched out or inverted saucer shaped lesions → Mid borderline (BB), borderline leprosy (BL)
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Ref - Davidsons 23e p1024
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Deep venous system of the brain is composed of the internal cerebral, basal and great cerebral vein and their tributaries. This system drains the deep white and grey matter surrounding the lateral and 3rd ventricles and the basal cisterns.The deep veins are divided into a ventricular group composed of veins converging ...
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Subglottic stenosis (SGS) is a narrowing of the subglottic airway, which is housed in the cricoid cailage. Myers and Cotton devised a classification scheme for grading circumferential subglottic stenosis from I-IV. The scale is based on a percentage of stenosis established by the age of the patient and the size of the ...
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Isotonic dehydration with acidosis is the most common finding in children with severe viral enteritis. In Diarrhoea- loss of bicarbonate in stools- causes normal anion gap metabolic acidosis.
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Multiple,small satellite lesions may be present around the ulcer,its a sign in fungal corneal ulcer.Reference:Comprehensive ophthalmology,AK Khurana,6th edition,page no.106
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Ans. a (Inquest). (Ref. Parikh, Textbook of FMT, 5th/5)INQUEST (legal or judicial inquiry to ascertain matter of fact). : Section 174 Cr.P.C. -# When a person dies it is necessary to determine the cause of death either natural or unnatural to meet with the requirement of law.# In forensic, an inquest generally means an...
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Ans: B i.e. Milk is a rich source
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Chancroid is an STD that presents as a genital ulcer. It is caused by H.ducreyi
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Neurofibromatoses are a group of clinically and genetically different autosomal dominant hereditary diseases that predispose to benign and malignant tumors of the nervous system. It is of two types NF 1 and NF2. Cutaneous neurofibromas occur in NF1, and NF 2 is associated with posterior subcapsular cataract. Ref: Harri...
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Ans. C i.e. Burns Antemoem burns The presence of carbon paicles in the terminal bronchioles on histological examination is absolute proof of life during fire. The soot is better seen by spreading a thin film of mucus on a clean sheet of white paper. Presence and amount of soot in air-passage depends on the type of fire...
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Ref Robbins 9/e p242 , Harrison 17/e p384;2061;2056;381 Hyper IgE Syndrome (HIES) is a rare primary immunodeficiency disease characterized by eczema, recurrent staphylococcal skin abscesses, recurrent lung infections, eosinophilia (a high number of eosinophils in the blood) and high serum levels of IgE But normal IgG ,...
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C i.e. Release norepinephrine Tyramine, ephedrine & amphetamine (TEA) augment autonomic activity by releasing norepinephrineQ from endings of post-ganglionic neurons. Stnne drugs and toxins affecting Autonomic activity /IP Site of Action Compounds That Augment Autonomic Activity Compounds That Depress Autonomic Activit...
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Ans. is a i.e. 500 gms The placenta at term Gross anatomy : It is a circular disc with diameter is 15 - 20 cms It is about 2.5 cm thick at the centre Weight is ,00 gmdeg Ratio of Weight of placenta : weight of fetus is 1 : 6deg it has 2 surfaces : Maternal surface Fetal surface It is formed by decidua basalis, It is fo...
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i.e. (Renin): (670-Ganong 23rd)RENIN - is a glycoprotein hormone secreted by the granular cells (Juxtaglomerular cells) of the Juxta glomerular apparatus.* Juxtaglomerular apparatus (JGA) lies at hilum of glomerulus** (Juxta means near)Secretion of renin is stimulated by four factors1. Fall in arterial blood pressure2....
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C i.e. Vernal conjunctivitis Staphylococcus has been mentioned as a causative organism for bacterial conjunctivitis which can present as Acute Purulent/Muco-purulent Conjuntivitis, Membranous/Pseuo-Membranous Conjunctivitis or Ophthalmia Neonatorum. And, corneal marginal ulcer Q is a complication of Acute Purulent/ Muc...
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Activity of acute anterior uveitis is indicated by presence of cells (aquous cells) and flare in anterior chamber -Grading is done on these two. Ref: Khurana 7th/e p.158 & 4th/e p.143.
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A i.e. Auditory tube
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Answer is B (Tuberculous Pyelonephritis) ruberculosis is the least impoant/common cause of necrotizing papillitis amongst the options provided. Causes of Renal Papillary Necrosis /Necrotizing Papillitis Analgesic Abuse Nephropathy (NSA1Ds) Diabetes Mellitus Sickle cell Disease Obstruction in association with infection ...
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Ans: d (All of the above)Ref: Still searching
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Thirst is also controlled by receptors in the anterior hypothalamus.
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Fascicular architecture of skeletal muscleThe major types of arrangement of muscle fibers or fasciculi are :-1) Parallel fasciculiThe muscle fibers or fasciculi are parallel to line of muscle pull.These muscles contract over a great distance (have maximum range of movement) and have good endurance.Convergent fasciculiT...
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Leishmania
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Most common cause of secondary postpaum hemorrhage is retained tissues Secondary postpaum hemorrhage is bleeding 24 hours to 12 weeks after delivery. Causes of PPH(10 and 20) : Uterine atonicity Injury to any pa of genital tract Coagulopathy (von Willebrand's disease) Retained tissues - MCC of 20PPH
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Microglia in CNS has phagocytic activity.
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Ans. (b) To put ICD in pleural effusion* Above triangle is known as Safety triangle.* This is the triangle where ICD is inserted at 5th ICS for Pleural Effusion
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Ans. is 'd' i.e., Median nerve o The median nerve controls coarse movements of the hand, as it supplies most of the long muscles of the front of the forearm. It is therefore called the "labourer's nerve".o The ulnar nerve is known as the musician's nerve as it supplies most of the small muscles of the hand.
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The child is most probably suffering from HIV infection. The clinical picture described in this question like recurrent diarrhoea, resistant oral thrush, gross underweight with hepatosplenomegaly are seen in HIV infection (AIDS). This clinical picture is absent in rest of the three conditions.
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The synopsis of forensic medicine & toxicology; Dr k.s Narayan reddy; 28th edition;pg.no. 88; Contusion or bruises are not washable but postmortem lividity is washable.
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Ans. is 'a' i.e., Allergic rhinitis Causes of epistaxiso Causes of epistaxis may be divided into : - i) Local (in nose and nasopharynx), ii) General, iii) Idiopathic.Common causes of epistaxisLocal causesSystemic causeso Trauma (nose-picking, fracture, nose plugs)o Hypertensiono Infection or inflammationo Arteriosclero...
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Eagleton criteria for diagnosis of cavernous sinus thrombosis are: → Known site of infection. → Ocular nerve paralysis (via lesions of cranial nerves, III, IV, V, VI). → Early obstructive signs (such as retinal vein fullness, proptosis, exophthalmos and collateral venous circulation). → Surrounding soft tissues abscess...
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Ans. is 'b' i.e., Nucleic acid amplificationRef: Harrison, 19th/e, p. 1165 and Ananthanarayan, 9th/e, p. 415NAAT (Nucleic acid amplification test) - PCR, LCR (Ligase Chain Reaction).Most sensitive test in cervical C. trachomatis.
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Struvite, a crystalline substance is composed of magnesium ammonium phosphate (MgNH4PO4 * 6H2O). Struvite urinary stones have also been referred to as "infection stones" and "triple phosphate" stones. Struvite stones can be caused by alkaline urine, steroid therapy, abnormal retention of urine, a urinary tract infectio...
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ANSWER: (B) PapillaryREF: Schwartz's Principles of Surgery 9th edition chapter 38, American Cancer Society. In turn citing: AJCC Cancer Staging Manual (7th ed), National Cancer Database in the US by F. Griinwald; Biersack, H. J.; Gr-umvald, F. (2005). Thyroid cancer Springer ISBN 3-540-22309-6 Page 10Prognosis depends ...
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Ans. Retinal haemorrhages
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