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IP3 / DAG: - Phospholipase catalyzes the breakdown of phospholipids in the cell membrane into two different second messenger products- IP3 & DAG. IP3 mobilizes the calcium ion from mitochondria & endoplasmic reticulum lumen to cytoplasm & then the Ca++ ions have their own IInd messenger effects, such as smooth muscle c...
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Ans. is d, i.e. AbortionRef. Williams Obs. 23/e, p 300; Dutta Obs. 7/e, p 107It must be quite surprising for some you that why I have not marked option "a" i.e. Limb abnormality as the answer.This is because Williams Obs. 23/e, p 300 says--"Early reports of an association between CVS and limb reduction defects, oromand...
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Inhibiting FSH secretion
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A European study of heterosexual couples in suggests that chances of transmission of HIV infection from male to female is twice as likely as from female to male. Reference; Park&;s Textbook of preventive and social medicine, 24th edition.Pg no. 364
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The patient is suffering from field deficit called upper right homonymous quadrantanopia, which is also known as Meyer's loop quadrantanopia.The lesion lies at the contralateral inferior (temporal) lobe. Area of lesion Type of Defect Disc/optic nerve lesions Same sided monocular blindness Chiasmal lesions Bitemporal He...
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A unique feature is a clinical severity and high case fatality rate of 20 -40 percent in pregnant women. Especially in the last trimester of pregnancy. REF:ANANTHANARAYAN AND PANIKER'S TEXTBOOK OF MICROBIOLOGY 9TH EDITION PAGE NO-550
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Rate of CSF formation normally remains constant and is independent of CSF pressure. CSF absorption by arachnoid villi is propoionate to CSF pressure. Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 33. Circulation through Special Regions. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Ed...
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Normal range of urine osmolality in humans ranges between 300-1200 mosmol/lRef: Ganong&;s Review of Medical Physiology, 23rd edition, page no: 654, 655
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Lateral pterygoid muscle opens the mouth by depressing the jaw. Masseter, medial pterygoid, and temporalis muscles close the jaw. Buccinator muscle is a muscle of facial expression.
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The features described are typical of complex partial seizure.the patient’s aura includes olfactory hallucination, which is usually associated with lesion of mesial temporal lobe (uncus and parahippocampal gyrus)
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Malignant hypehermia (MH) is a rare (1:15,000 in pediatric patients and 1:40,000 in adult patients) genetic hypermetabolic muscle disease, the characteristic phenotypical signs and symptoms of which most commonly appear with exposure to inhaled general anesthetics or succinylcholine (triggering agents). MH may occasion...
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Ans. (d) To remove foreign bodyRef.: Harrison 19th ed. /1667Foreign body is removed by rigid bronchoscopy.Indications for Rigid Bronchoscopy* Bleeding or hemorrhage* Foreign body extraction* Deeper biopsy specimen when Fiber-optic specimen is inadequate* Dilation of tracheal or bronchial strictures, relief of airway ob...
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Hypotension (shock) causes tissue hypoxia leading to production of lactic acid and this lactic acidosis is th6 most common cause of metabolic acidosis seen during anaesthesia.
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Formaldehyde (formalin) is not used in poisoning because extraction of poisons especially non-volatile organic compounds become difficult in chemical analysis.
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Ans. is 'a' ie Common on the Rt. side Varicocele is seen on left side in 95% of cases VaricoceleIt is seen 95% of times on left side.Several anatomic features contribute to the predominance of left-sided varicoceles. The left internal spermatic vein is longer than the right; in addition, it usually joins the left renal...
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Ans. is 'a' i.e., Ewing's Sarcoma
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Both sporadic and familial RCC is associated with: Loss of sequence on chromosome 3 either by translocation (3:6, 3:8, 3:11) or deletion. This region harbours the VHL gene. Familial RCC is associated with:- Von Hippel-Lindau syndrome Ref: RAM DAS NAYAK EXAM PREPARATORY MANUAL FOR UNDERGRADUATES 2nd ed. pg no: 633
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A try in is not possible for immediate dentures. Therefore esthetics would be unpredictable.
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Prostate cancer is the most common malignancy in men in the UK, with a prevalence of 105 per 100 000 population. It is also common in nohern Europe and the USA (paicularly in the African American population) but is rare in China and Japan. It is uncommon in India but the incidence is increasing. Prostate cancer rarely ...
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Morgagni hernias are related to maldevelopment of the embryologic septum transversum and to failed fusion of the sternal and costal fibrotendinous elements of the diaphragm. These hernias are generally asymptomatic and usually detected as incidental findings on radiographs.
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1,25(011) 2 vit-D (Ref: Harper 26/e, p 484-485; Harrison 16/e, p 2246: Chatterjee Shinde Biochemistry 6/e, p 151] Synthesis and metabolism of Vitamin D Calcidiol may undergo 24-hydroxylation to yield an inactive metabolite, 24, 25-dihydroxy vit. D mediated by vit. D 24 - hydroxylase. 1, 25 (01-1)2D is the major inducer...
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D i.e. Act on dorsal horn cells
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According to lattice hypothesis, precipitation results when a large lattice is formed consisting of alternating antigen and antibody molecules. This is possible only at the zone of equivalence. At the zone of equivalence, antigen and antibody are in optimum propoion. Lattice formation and visible reactions are enhanced...
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Some cardiac fibers have the capability of self-excitation, a process that can cause automatic rhythmical discharge and contraction. This capability is especially true of the fibers of the hea's specialized conducting system, including the fibers of the sinus node. For this reason, the sinus node ordinarily controls th...
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Ans. is 'c' i.e., Laryngeal
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Hydrocyanic acid is not muriatic acid. Oil of vitriol - Sulphuric acid Muriatic acid - Hydrochloric acid Aqua fois - Nitric acid Carbolic acid - Phenol Salt of sorrel - oxalic acid
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Treatment of carcinoma Gallbladder Gallbladder cancer: Incidental pathological finding after laparoscopic cholecystectomy T1a with negative cystic duct margin : No fuher therapy T1a with postive cystic duct margin : Reresection of cystic duct or CBD to negative margin T1b, T2, T3 tumor with no evidence of metastasis : ...
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Malignant hypehermia is hypermetabolic state with following clinical features 1. Marked increased metabolism Increased co2 production Increased oxygen consumption Reduced mixed venous oxygen tension Metabolic acidosis Cyanosis Hypehermia 2. Increased sympathetic activity Tachycardia Hypeension Arrhythmias 3. Muscle dam...
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Mosquitoes belonging to the genera Culex,Aedes and Anopheles act as intermediate host The major vector in India is Culex quinquefasciatus (refer pgno:168 baveja 3 rd edition)
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Giving antibiotics prior to surgery (prophylactic antibiotics) one hour before surgery has been identified as an intervention for prevention of surgical site infections. Shaving is now avoided and clipping of hair is preferred. Preop bath, Blood glucose control, and maintaining normothermia (esp in colorectal surgery) ...
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Hemolytic anemia Hemolytic anemia is anemia due to hemolysis, i.e. the abnormal breakdown of red blood cells. Hemolytic anemia has the following features - A shortened red cell lifespan, i.e. premature destruction of red cells. Elevated erythropoietin level and increased erythropoiesis in the marrow and other sites,...
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Autoantibody seen in drug induced liver inuury is Anti LKM2 antibody. It is directed against cytochrome P 450. Ref: Harrison, Edition-18, Page-2560
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Dopamine activates b1-receptors and this was probably the reason for the arrhythmia. Amrinone will inhibit phosphodiesterase and result in an increased cyclic AMP level, producing the same result as b-receptor stimulation. Dobutamine and epinephrine also stimulate the b- receptors. The only choice which stimulates only...
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Glutaraldehyde is especially effective against the tubercle bacilli, fungi, and viruses. It is less toxic and irritant to eyes and skin than formaldehyde. It has no deleterious effects on the cement or lenses of instruments such as cystoscope and bronchoscope. It can be safely used to treat corrugated rubber, anestheti...
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Ans. (b) Metabolic alkalosis* In HPS, hypertrophy of the circular muscle of the pylorus results in constriction and obstruction of the gastric outlet.* Most commonly clinical presentation is seen between 3-6 weeks of life* Clinical features:* Projectile nonbilious vomiting* Visible gastric peristalsis may be seen as a ...
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Ans. (c) 512 HzRef: Dhingra's ENT 6th ed./22, 5th ed. / 26
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Ans. C: Folk acid Deficiency of : Thiamine causes Ben Beni, neuritis Pyridoxine causes Convulsion, hyperirritability Folic acid causes sprue, Anemia and neural tube defect in the newborn born to folate-deficient mothers Cyanocobalamin causes pernicious anemia, loss of vibration and position sense, dementia, abnormal ga...
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Ans. is 'd' i.e., Aromatase inhibitors Drugs commonly used in hormone (estrogen) receptor positive breast cancero SERMs:- Tamoxifen, tromifeneo SERDs:- Fulvestranto Aromatase inhibitors:- Letrozole, anastrazole, exemestone.
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The mammographic appearance of breast depends on the relative amount of fat and glandular tissue which are present. Young woman's breast contains a large proportion of glandular tissue which appears as a soft tissue density and lowers the sensitivity of mammogram. Mammographic appearance of breast (Based on the relativ...
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Hot air is useful for sterilizing aicles such as glassware, syringes, swabs, dressing, French chalk oil , Vaseline and sharp instruments. The drawback of hot air is that it has no penetrating power and is not suitable for disinfection of bulky aicles such as mattresses Ref: 25th edition, Park's Textbook of Preventive a...
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Ans. is 'b' i.e., Calcaneum [Ref: Maheshwari 5th/e p. 167Radiological angles on Lateral view of Calcaneum* Bohler's Tuber Joint Angle and Crucial Angle of Gissane are measured for Intra Articular Fractures of Calcaneum.1) Bohler's angle (tuber joint angle)# It measues the angular relationship between talus and calcaneu...
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Ans. a. Cognitive behavioral therapyPost Traumatic Stress Disorder (PTSD)It is an intense, prolonged and sometimes protracted or delayed response to exceptionally intense stressful eventse.Etiology:Events involving actual or threatened serious injury or death of the person or otherNatural disasters, man made calamities...
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Ans. is 'c' i.e., Decreased gut motility o The gastrointestinal tract has a nervous system all its own called the enteric nervous system. It lies entirely in the wall of the gut, begining in the esophagus and extending all the way to the anus. The enteric nervous system is composed mainly of two plexus: -Myenteric plex...
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(D) Clozapine # Clozapine can cause agranulocytosis and seizures as side-effects, it should be used with caution.ANTI PSYCHOTIC DRUGSA. Typical Or Traditional Antipsychotics1. Chlorpromazine (CPZ)300-15002. Thioridazine300-8003. Trifluoperazine15-604. Haloperidol5-1005. Pimozide4-126. Triflupromazine100-4007. Prochlorp...
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Park&;s texbook of Preventive and Social Medicine 23rd edition Page no: 166 Currently available meningococcal vaccines include polysaccharide vaccines and polysaccharide-protein conjugate vaccines. Both vaccines are available against meaningococci of serogroup A, C, W135 and Y
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Genetic abnormalities in haemophilia : Inversions: Intron 22 inversion, Intron 1 inversion Point mutations: Missense mutation, nonsense mutation, frameshift mutation Deletion of pa or whole of gene Inseion of repetitive sequences Splicing errors affecting production of mRNA Hemophilia A(factor 8 deficiency) -x linked r...
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Difference between Gram positive cell wall and gram negative cell wall Structure Primary Functions Chemical Constituents Gram- Positive cell wall Peptidoglycan osmotic stability, structural integrity, cell shape; permeable to antibiotics Thick meshwork of peptide cross-linked polysaccharide chains Teichoic and lipoteic...
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Neostigmine is an anticholinesterase used to reverse effects of muscle relaxants in all of the above conditions except for Phase 1 block by depolarizing muscle relaxants.
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Hodgkin lymphoma is currently classified in the following manner: Nodular lymphocyte-predominant Hodgkin lymphoma. Classical Hodgkin lymphoma (comprising five histopathologic subtypes): Lymphocyte rich Nodular sclerosis Mixed cellularity Lymphocyte depletion Unclassifiable These names describe the most prominent hi...
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Answer: a) Serial evaluation of liver functions in a 54 years female with metastatic carcinoma breast with doxorubicin chemotherapyCT is preferred than MRI for Serial evaluation of liver functions in a 54 years female with metastatic carcinoma breast with doxorubicin chemotherapy
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In reality the pseudomyxoma peritonei or "jelly belly" probably represents mucinous ascites, in association with a cystadenoma of the appendix (resulting in true PMP); to frank mucinous adenocarcinoma. Additionally intestinal mucinous tumours, paicularly colorectal cancers, or any mucinous neoplasm may present with cli...
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Ans. (c)The immature T. trichiura buries its entire body in the epithelium of the large intestine forming a tunnel. As the worm matures, its posterior portion is extruded or ruptures from the tunnel and hangs in the intestinal lumen.Intimate contact of T. trichiura with the mucosa of large intestine leads to inflammati...
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Most testicular neoplasms in the first 4 years of life are classified as yolk sac tumors. Microscopic examination of a yolk sac tumor shows interlacing strands of epithelial cells surrounded by loose connective stroma. The lobular arrangement of cells, surrounded by empty spaces, leads to the formation of glomeruloid s...
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Ans. is 'b' i.e., Hypercalcemia Tumour lysis svndrome|Destruction of large number of rapidly proliferating cellsHyperuricemiaHyperphosphatemiaHyperkalemia|||Uric acid pptCauses reciprocalArrhythmiasin tubulesdecrease in calcium || Renal failure-Hypocalcemia
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The uvrABC endonuclease is an enzyme that is involved in the repair of DNA that has been damaged by thymine dimer formation. It cuts a DNA strand on both sides of the thymine dimer, which allows the damaged region of DNA to be removed. DNA repair is completed by the action of DNA polymerase I, which fills in the gap wi...
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Ans. is 'b' i.e., Nitric acid o Nitric acid causes yellow discoloration of the tissues including the crowns of the teeth & yellow stains on the clothing,o Inhalation of fumes causes lacrimation, photophobia, irritation of air-passages & lungs producing sneezing, coughing, dyspnea & asphyxia,o The color of urine is brow...
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Femoral and Popliteal aery aneurysms Femoral and Popliteal aery aneurysms constitute about 90% of peripheral aneurysms. Femoral 20% and Popliteal 70%. The majority of these aneurysms are the degenerative type. More common in men. Popliteal aery aneurysms are almost always seen in men (97%) More than 50% are bilateral. ...
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SPECIAL FEATURES 1)  Susceptibility to A) Hypoxia                     B > A > C B) Pressure                    A > B > C C) Local Anasthesia      C > B > A 2) Diameter A alpha > A beta > A gamma > A delta > B > C 3) Velocity A alpha > A beta > A gamma > A delta > B > C 4) a)Large axons are associated with  Proprioce...
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Ans. is 'b' i.e., Enters skull through foramen magnum Vertebral arteryo It is the largest branch of subclavian artery.o Vertebra] artery traverses through vertebral triangle, foramina transversaria of upper six cervical vertebrae. suboccipital triangle, posterior atlanto-occipital membrane, vertebral canal, pierce dura...
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Ans. is 'b' i.e., Speech discrimination is highly impaired Cochlear SNHLRetrocochlear SNHLDamage to hair cellsDamage to VIII nerve and its connectionsRecruitment presentRecruitment AbsentNo significant tone decaySignificant tone decaySISI PositiveSISI NegativeSpeech discrimination not highly impairedSpeech discriminati...
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Ans. is 'd' i.e., Bladder
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Cerebrosides are both present as galactocerbrosides and glucocerebrosidesGalacto cerebrosides in neural cells and glucocerebrosides in the non neural cells.
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Ans- D Optic Neuritis A. Papilitis Most common causes : Multiple sclerosis. Ophthalmoscopic features: Swollen optic disc up to 2 D Hyperemic disc. Disc margins blurred. Clinical feature Usually U/L Sudden loss of vision. Pain on eye movement (retrobulbar neuritis) Marcus gunn pupil or RAPD (Relative Afferent Pupillary ...
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In donovanosis there are subcutaneous granulomas in inguinal region, which look like enlarged lymph nodes, but they are not enlarged lymph nodes. So, they are referred to as pseudobubo.
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Besides staphylococcus aureus, a few other coagulase positive species are Staphylococcus intermedius and Staphylococcus hyicus. These are animal parasites and do not infect humans. Coagulase-negative staphylococci are Staphylococcus epidermidis, staphylococcus hemolyticus, and Staphylococcus saprophyticus. They are the...
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Monoamniocity in mono chorionic twins leads to high perinatal moality due to cord problems(entanglement) Reference:DD Dutta&;s textbook of obstetrics,8th edition,page no:240. <\p>
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The cervix is the inferior end of the uterus that projects into the vagina. This means that the vagina comes up and wraps around the cervix, creating the vaginal fornix. There are multiple fornices at the top of the vagina: anterior, posterior, and lateral. The cervical canal is the passageway through the cervix to the...
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Exocytosis is a calcium dependent process. In non-constitutive exocytosis, secretory product after synthesis and processing in the RER and GA, is stored in the cytoplasm in secretory granules until an appropriate signal for secretion is received In constitutive exocytosis, prompt transpo of secretory product to the cel...
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Sub Arachnoid Hemorrhage Most common cause : Trauma >Spontaneous rupture of Berry aneurysm Clinical features Sudden transient loss of consciousness (occurs in nearly half of the patients) Excruciating severe headache: presenting complaint in 45% of cases (worst headache of patients life) more common upon regaining cons...
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Ref:- Ganong's Review of Medical Physiology 25th ed; pg num:- 243
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The shapes of RBCs can change remarkably as the cells squeeze through capillaries. Actually, the RBC is a "bag" that can be deformed into almostany shape.
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Ans. a (Uronic acid) (Ref. Harper's Biochemistry-26th/pg. 105, 163, 170; 27th/pg. 177)Glucuronic acid is synthesized from glucose via the uronic acid pathway, of major significance for the excretion of metabolites and foreign chemicals (xenobiotics) as glucuronides. A deficiency in the pathway leads to essential pentos...
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Ans. is a, i.e. If anomaly scan not done at 1st trimesterFor anomaly scan copy USG is done in 1st trimester and repeated at 16 to 20 weeks. There is no use getting a scan done in third trimester as MTP cannot be done beyond 20 weeks.
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Ref: Koeppen BM, Stanton BA. Skeletal Muscle Physiology. In: Berne & Levy Physiology 6th ed. Mosby; 2008 p 250. & Hershko A, Ciechanover A. The uhiquitin system. Anna Rev Biochem. 1998:67:425-79.Explanation:"One factor thought to contribute to the decreased protein synthesis and increased protein degradation during per...
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Individuals with DM have a greater frequency and severity of infection. It is due to abnormalities in cell-mediated immunity and phagocyte function associated with hyperglycemia, as well as diminished vascularization. Hyperglycemia aids the colonization and growth o f a variety of organisms . Most commonly by Candida a...
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Ans. b. Parotid gland
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ANSWER: (A) HyperparathyroidismREF: Essentials of aic Radiology: A Multimodality Approach - Page 276Subperiosteal bone resorption is pathognomic of hyperparathyroidism. In the skull areas of reduced radiopacity is intermingled with sclerotic radiopaque areas to give a characteristic "salt and pepper appearance"
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Ans. is 'c' i.e., B-Scan Vitreous hemorrhageo Vitreous hemorrhage refers to bleeding into the vitreous chamber or a space created by vitreous detachmento Causes of vitreous hemorrhage are :i) Posterior vitreous detachment.ii) Proliferative diabetic retinopathy.iii) Eale's disease & Coat's disease.iv) Retinal tear (brea...
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Posterior urethral valves are a problem with the urethra in a boy. The urethra is the tube that drains urine from the bladder to the outside of the body. These valves are small leaflets of tissue in the urethra. They paly block urine flow because not enough urine can get through them to leave the body. Reference: GHAI ...
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Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes mainly T-cells Reff: www.mayoclinic.com
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Chronic alcoholism
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Ref Robbins 9/e p97 Delayed type of hypersensitivity results from accumulation of mononucleated cells around small veins and venules producing a perivascular cuffing .mono cytes transform into macrophages which undergo morphological changes to produce epitheliod cell
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Patients with acquired cholesteatomas typically present with recurrent or persistent purulent otorrhea and hearing loss. The discharge is scanty & always foul-smelling due to bone destruction. Facial nerve twitching, palsy, or paralysis can also result from the inflammatory process or from mechanical compression of the...
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??' The given picture shows Bitot's spots, seen in Vitamin A deficiency. ??' Bitot's spots : Foamy appearance in conjunctiva due to superficial deposition of keratin in conjunctiva . Vitamin A deficiency (VAD), as graded by the WHO: Night blindness (XN) Conjunctival xerosis (X1A) Bitot's spots (X1B) Corneal xerosis (X2...
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Xerophthalmia The term xerophthalmia is now reserved (by a joint WHO and USAID Committee, 1976) to cover all ocular manifestations of vitamin A deficiency, including not only the structral changes affecting the conjunctiva, cornea and occasionally retina, but also the biophysical disorders of retinal rods and cones f...
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Ans. is 'd' i.e., Nabumetone o All NSAIDs are acidic in nature except nabumetone.
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Features of the Genetic CodeDegenerateUnambiguousNonoverlappingNot punctuatedUniversalRef: Harper&;s Biochemistry; 30th edition; Chapter 37; Protein Synthesis & the Genetic Code
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Inhaled steroid medications for better asthma control include: Beclomethasone dipropionate(Qvar) Budesonide (Pulmico) Budesonide/Formoterol (Symbico) - a combination drug that includes a steroid and a long-acting bronchodilator drug. Fluticasone (Flovent) Fluticasone inh powder (Arnuity Ellipta) Dexamethasone Use in pr...
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Abnormal schilling test implies impaired vitamin B12 absorption It can be due to: Pernicious anemia Chronic pancreatitis Bacterial overgrowth Ileal disease Schilling test becoming normal after giving antibiotics implies Bacterial overgrowth. In bacterial overgrowth syndrome there is migration of large intestine flora i...
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Ref Ajay yadav 2/e p 73 Treatment of accidental intra aerial injection of thipentone is Immediately stop fuher injection Leave the needle at site Inject heparin through this needle Inject papaverine through this needle If vasodilators like papaverine are not available ,xylocaine can be used Brachial plexus or stellate ...
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Ans. B Descent in air Ref. Dhingra 5th/ed p 74, 6th/ed p 66 Otitic Barotrauma: It this condition, Eustachian tube fails to mantain middle ear pressure at ambient atmospheric level Etiology: Rapid descent during airflight Underwater diving Compression in pressure chamber. Mechanism When middle ear pressure rises | Norma...
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Type IV thyroplasty- This procedure is used to lengthen (tighten) the vocal cord and elevate the pitch. It conves male character of voice to female and has been used in gender transformation. It is also used when vocal cord is lax and bowing due to ageing process or trauma. Ref: PL Dhingra Textbook of Ear, Nose and Thr...
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If we are doing resuscitation of a pregnant female in cardiac arrest and no successful in return of spontaneous circulation within 4 min then we have to go for perimoem cesarean section. If attempts at maternal resuscitation fail, consider immediate cesarean section. Gestational age greater than 23 weeks is the recomme...
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Radio-immunoguided surgery procedureinwhichradiolabeledsubstancesareadministeredandtumorsareexcisedbasedonthelocationofradioactivesignals Radio-immunoguided surgery for colorectal cancer The intra-operative detection of metastatic disease in colorectal cancer depends on tumor associated antigen and antibodies as well a...
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Ans. is'a' i.e., ADH o Blood pressure is regulated by following mechanisms.A) Short term regulation# These mechanisms act immediately and correct the blood pressure quickly. These arei) Baroreceptor reflex: Works during BP range 70-150 mmHg.ii) Chemoreceptor reflex: Works when BP below 80 mmHg.iii) CNS ischemic respons...
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Prophylactic craniospinal irradiation is given in:- medulloblastoma, SCC lung, Glioblastoma, Germinoma, ALL, Non-Hodgkin's lymphoma (NHL), Leptomeningeal rhabdomyosarcoma
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Keshan disease is endemic cardiomyopathy due to selenium deficiency.
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As a signatory to the Alma-Ata Declaration,the government of India was committed to achieving the goal of Health for All through primary health care approach which seeks to provide universal comprehensive health care at a cost which is affordable (refer pgno:902 park 23rd edition)
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ANORECTAL ANOMALIES Anatomically classified as high,intermediate or low An Xray film of the abdomen is obtained 12-24 hours after bih,with the baby being kept in an inveed position. a lateral picture of the pelvis obtained to define whether the rectal pouch is above or below the line drawn from the pubis to coccyx. Ano...
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