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Refer Goodman Gilman 12/e p 1296 The serious adverse effects noted with most of bisphoshonates is osteonecrosis of jaw bone Zoledronate can cause serious side effects as Nephrotoxicity and renal failure
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The inferior turbinate is a separate bone, while rest of the turbinates are a part of ethmoidal bone.
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Structures located between the X-ray source and moving center of rotation (orange zone) cast ghost images. On the panoramic image, ghost images appear on the image on the opposite side of its true anatomic location and at a higher level, because of the upward inclination of the X-ray beam. Because the object is located...
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A i.e. 50- 60 microns
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Pompe's disease (Type H glycogenosis) is due to deficiency of acid maltase (lysosomal α l →4 and α l→6 glucosidase).
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B i.e. HgF 2,3. DPG does not combine with fetal hemoglobin 2,3DPG & Hemoglobin 2,3 DPG is present in high concentration in erythrocytes (HbA> HbA2) 2,3 DPG greatly reduces the affinity of Hb to O2 Q (shifts O2-dissociation curve to right) Fetus Hb (HbF) consists of a2Y2, this tetramer has much lower affinity for 2-3 DP...
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Gallstones, which affect 10 to 20% of the adult population in developed countries, are divided into two main types. Cholesterol stones are pale yellow, hard, round, radiographically translucent stones that are most often multiple. Their formation is related to multiple factors including female sex hormones (such as wit...
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The hematopoietic syndrome results from acute whole-body doses above 200 rads. A prodromal phase consists of nausea and vomiting within the first 12 hrs, with symptoms usually lasting up to 48 hrs. A latent period of 2-3 wks during which patients may feel quite well follows. Although patients are asymptomatic, bone mar...
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Ans. Nervous tissue
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Ans-C
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Cushings reflex is a special type of CNS ischemic response. The cause is raised intracranial tension. When blood flow to the VMC is decreased., it suffers from ischemia. The VMC is stimulated leading to vasoconstriction and increase in BP. There is simultaneous stimulation of cardioinhibitory center by sinoaoic reflex ...
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Ans. D: Echocardiography The presence of a nonejection click on physical examination is sufficient to make the diagnosis of mitral valve prolapse. The sound has a sharp high-frequency clicking quality and, although often confined to the bit apex, can be transmitted widely on the precordium. The cause of the sound is du...
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Ans. D. Identifying maladaptive assumptionsBehavioral Techniques:This includes the various sho-term modalities like social skills training problem solving techniques, asseiveness training, self-control therapy, activity scheduling & decision-making techniques.Among the behavioral techniques in cognitive therapy are sch...
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ANSWER: (D) Transitional carcinoma of the pelvis extending till ureterREF: Sabiston 18th ed chapter 77The standard treatment of renal pelvis and upper ureteral urothelial carcinomas includes complete nephroureterectomy with excision of the distal ureteral cuff from the bladder
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Decrease in PaO2 stimulates the peripheral chemoreceptors at high altitudes. This triggers hyperventilation. Hyperventilation results in CO2 washout and respiratory alkalosis. This is compensated by increased excretion of bicarbonates by the kidney.
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Section 320 IPC Grievous The following kinds of hu only are designated as "Grievous": First - Emasculation Second - Permanent privation of the sight of either eye Third - Permanent privation of the hearing of either ear Fouh - Privation of any member or joint Fifth - Destruction or permanent impairing of the powers of ...
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RECTAL POLYPS Occur most commonly in children < 5 years of age. Occur as a single lesion of the rectum. Typical symptoms are rectal bleeding, mucus discharge, diarrhea, and abdominal pain. Can cause bleeding, or pain if it prolapses during defaecation
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Ciclopirox olamine(nail lacquer) is most effective topical drug for Rx of mild to moderate onychomycosis Drug for Rx onychomycosis Dose Terbinafine 250 mg/day for 6 and 12 wks in fingernail and toenail onychomycosis respectively. Itraconazole Pulse therapy: 200 mg twice daily for 1 wk/month for 2 and 3 consecutive mont...
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Nissl bodies are basophilic bodies or granules composed of many thin, parallelly arranged, membrane-bounded cavities or cisternae which are covered by many minute paicles consisting of Ribose nucleoproteins i.e. RNA with proteins. Granule&;s size and number vary with physiological condition of the cell. For example, fa...
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Vaccum Erection Device Therapy In patients who donot respond to or decline oral or local vasoactive pharmacotherapeutic options, vaccum erection device therapy may be alternatively explored. The principle of vaccum erection device therapy is to mechanically create negative pressure surrounding the penis in order to eng...
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Retinoblastoma is the most common primary intraocular malignancy of children. Cell of origin of retinoblastoma is a neuronal progenitor. In approximately 40% of cases, retinoblastoma occurs in individuals who inherit a germline mutation of one RB allele In the sporadic cases, both RB alleles are lost by somatic mutatio...
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Moderate to severe protein energy malnutrition reduces risk of DHF/DSS in dengue-infected children Treatment of DHF: None specific – Paracetamol – ORS, Oral fluids – I/V fluids, IV colloids – Blood transfusion
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Drugs causing DLE ( Drug induced Lupus Erythematosus ) can also be asked as drugs undergoing metabolism by liver acetylation. Such drugs are: C- SHIP C-Chlorpromazine S - Sulfonamides H - Hydralazine I - Isoniazid P - Procainamide
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The general rule in that : Myopathies have proximal muscle weakness. Neuropathies have distal muscle weakness. Myotonic dystrophy is an exception to this general rule and mainly involves the distal muscles. Also know The difference between myopathy and muscular dystrophy. Myopathy Any skeletal muscle disorder t...
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Here note that the serum peak oestradiol is very high and she had received an injection as a pa of her treatment for infeility which may have been human chorionic gonadotropin. This resulted in ovarian hyperstimulation syndrome. In Budd Chiari syndrome or Meigs syndrome oestradiol need not be this high. Note that throm...
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Extensor digitorum Hybrid muscles are the muscles having more than one nerve supply Pctoralis major: lateral & medial pectoral nerves Brachialis: additional proprioceptive fibres from radial nerve, in addition to its muscular nerve, musculocutaneous nerve. Extensor digitorum is supplied by the posterior interosseous ne...
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The fibrous and parietal pericardia are supplied by phrenic nerves.They are sensitive to pain.Pain of pericarditis originates in the parietal pericardium alone. B D CHAURASIA'S HUMAN ANATOMY UPPER LIMB THORAX-VOLUME-1 SIXTH EDITION Page no-251
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Gallstones In the USA and Europe, 80% are cholesterol or mixed stones, whereas in Asia, 80% are pigment stones Cholesterol or mixed stones - 51-99% pure cholesterol Pigment stone contains <30% cholesterol Black stones - Insoluble bilirubin polymer + calcium phosphate + calcium bicarbonate Brown pigment stones- calcium ...
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Tetralogy of Fallot (TOF) is a cardiac anomaly that refers to a combination of four related hea defects that commonly occur together. The four defects are: Ventricular septal defect (VSD) Tetralogy of Fallot results in low oxygenation of blood. This is due to: Mixing of oxygenated and deoxygenated blood in the left ven...
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Gynecomastia is the abnormal growth of mammary glands in males. Polythelia refers to supernumerary nipples. Polymastia refers to supernumerary, or extra, breasts. Amastia refers to the absence of breasts.
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SAR of measles = 80% and Rubella = 90%
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B i.e. RV decreased
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Ans. is 'c' i.e. Microdochotomy
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Beckwith - Wiedmann syndrome : Oragnomeagly seen like macroglossia, omphalocele, hemihypertrophy, adrenal cytomegaly. There is increased risk of Wilm's tumour.
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Ans is 'c' i.e., Stage 2 NREM Stages of sleepo Sleep is basically divided into two phases :-Non-REM (NREM) or slow-wave sleep It is called Non-REM sleep because no rapid eye movement (REM) is there on eletrooculogram, rather there is slow or quiscent eye movement. It is also referred as S- sleep (synchronized sleep) or...
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Ref:Pathologic Basis of Disease (Robbins and cotran) 7th edition ,page no.765 Mediastinal tumors and other mass Superior Mediastinum Lymphoma Thymoma Thyroid lesions Metasttic carcinoma Parathyroid tumors Anterior Mediastinum Thymoma Teratoma Lymphoma Thyroid lesions Parathyroid tumours Posterior Mediastinum Neurogenic...
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Lumbar spinal stenosis is defined as narrowing of the spinal canal, its lateral recesses, and neural foramina that results in a compression of lumbosacral nerve roots. The hallmark of spinal stenosis is bilateral pseudoclaudication. It is induced by standing or walking and is relieved by sitting or flexing forward. Ped...
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Ans. c. Previous classical cesarean section Trial of normal vaginal delivery is contraindicated in previous classical or inveed-T shaped uterine incision cesarean section. Vaginal Bih After Cesarean (VBAC) Trial of Labour (TOL Selection Criteria One previous lower segment transverse scarQ Pelvis adequate for the fetusQ...
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(B) II & III degree heart block# Except for those drugs specifically approved for use in heart failure, beta blockers are contraindicated in heart failure patients> Side effects of beta-blockers are related to their cardiac mechanisms and include bradycardia, reduced exercise capacity, heart failure, hypotension, and a...
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Ans-A
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hea : strychinine , digoxin Skin- Hypodermic injections, snake bite, Corrosives. Hair, Nails- Heavy Metal Poisoning. Spinal Cord- Strychnine Poisoning CSF- Alcohol intoxication (in 1.0 mg NaF/ml of fluid) Urine- Narcotics Body Fat- Endrin , DDT(Organo Chlorines). Muscle- When internal organs are badly putrefied. ref : ...
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(D) Neurosarcoidosis# NEUROSARCOIDOSIS generally occurs only in cases of sarcoidosis with substantial systemic involvement, and signs of neurologic involvement usually are seen in patients known to have active disease.> Strictly neurologic forms are seen in fewer than 10% of patients; a subset has predominantly neuromu...
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Metabolic syndrome/Syndrome X: Central obesity: Waist circumference >102cm in males,>88cm in females. Hyperiglyceridemia: >150mg% Low HDL cholesterol: <40mg%I(male), <50mg% (female) Hypeension: >130/80 mmHg Fasting blood glucose >100 mg% / previously diagnosed type 2 diabetes. NOTE:Raised LDL is NOT a feature of Metabo...
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Ans. is 'c' i.e., Noncompetitive reversible inhibitor Brinzolamide is a white powder formulated as l% ophthalmic suspension to reduce intraocular pressure.Pharmacologically Brinzolamide is a highly specific noncompetitive reversible and effective inhibitor of carbonic anhydrase II (CA-II) which is able to suppress form...
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Ans. Southern blotting
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Ans. is 'a' i.e., Jealousy o Symptoms of conversion disorder:Sensory:- Anesthesia, paresthesia, hemianesthesia, deafness, blindness, tubular vision.Motor .--Abnormal movement, paralysis, weakness, gait disturbances, aphonia, torticollis, opisthotonus, blephrospasm.
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Reversal of the reaction catalyzed by pyruvate kinase in glycolysis involves two endothermic reactions. Mitochondrial pyruvate carboxylase catalyzes the carboxylation of pyruvate to oxaloacetate, Key Gluconeogenic Enzymes 1. Pyruvate carboxylase.Pyruvate Carboxylase Reaction Pyruvate in the cytoplasm enters the mitocho...
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Extra-ocular muscles are composed of white fibres (type II B), which contract quickly with peak tension attained within 7.5 msec of stimulation. Type I or 1 Type II A or 2A Type II B or 2X Other names Slow, Oxidative (SO) Fast, Oxidative, glycolytic (FOG) Fast Glycolytic (FG) Function Sustained forces, such as postural...
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Ans. is `d' i.e., Oliguria due to uretic obstruction
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Ans: b (Anxiety) Ref: Ahuja, 6th ed, p. 95; Kaplan & Sadock, 8th ed, p. 1719Pharmacological treatment of anxiety disorders includes the use of benzodiazepines, beta blockers, buspirone and anti depressants.Antidepressants are among the most effective antianxiety agents available. SSRIs have been shown to help reduce or...
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All the exocrine glands are lined by pseudo stratified cuboidal/columnar epithelium with few exceptions. One of them is sebaceous gland duct which caries the epithelium same as that of the skin (stratified squamous epithelium) Ref: IB textbook of histology 6e pg 54.
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WORKING PRINCIPLE : light bulbs heat air in the bottom pa of the incubator,the air passes over a container with evaporating water, so that its humidity increases,the warm, humid air then flows upwards (chimney effect) into the baby compament Reference: GHAI Essential pediatrics, 8th edition.
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Trigeminal
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(Ref: Katzung 14th ed. P 755)Insulin glargine is a soluble, "peakless" (i.e. having broad concentration plateau), long acting insulin analogue.Onset: 1-1.5 hours. Duration of action: 11-24 hours.Summary of bioavailability characteristics of the insulinsInsulin preparationsOnset of actionPeak actionEffective durationIns...
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Ans. is 'd' i.e., Succinate thiokinase o There are 2 types of phosphorylation of ADP to ATP.Substrate level phosphorylationOxidative phosphorylation at respiratory' chain levelo Substrate level phosphorylation is the production of ATP at the substrate level without participation of ETC.o It occurs in TCA cycle and glyc...
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The biological tests for pregnancy are: 1) Aschheim - Zondek test 2) Rapid rat test 3) Friedman test 4) Hogben or Female toad test 5) Male frog test 6) Galli - Mainini test Alo know: Indirect and direct latex slide tests are immunological tests. Ref: Textbook of Forensic Medicine and Toxicology by Narayan Reddy, Editio...
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Ans. is 'a' i.e., G1- S phaseo Phosphorylation of RB is a molecular "On-off' switch for cell cycle.o It regulates cell cycle at G,- S phase (has been explained in details in previous explanations).
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Inguinal triangle is a region defined by the following structures:Rectus abdominis muscle (medially)Inguinal ligament (inferiorly)Inferior epigastric vessels (superior and laterally)It is the region in which direct inguinal hernias protrude through the abdominal wall.The Hesselbach triangle is bounded by the inguinal l...
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.
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Ans. B. 63 degrees for 30 minutes.a. Holder method of pasteurization-moist heat at 63 C for 30 minutesb. Flash method of pasteurization-moist heat at 72 C for 15-20 seconds followed by quickly cooling to 13 C.c. Ultra-High Temperature (UHT) of pasteurization-moist heat 140degC for 15 sec/ 149deg C for 0.5 sec.
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Ans. (B). ScaldsLocal effects of heat & cold:Dry heat: Flame burnsMoist heat: scaldsDry cold: Frost biteMoist cold: Immersion foot
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.ACHALASIA CARDIA is a failure of relaxation of cardia (oesophagogastric junction) due to disorganised oesophageal peristalsis, as a result of a failure of integration of parasympathetic impulses causing functional obstruction.Aetiology comprises of, * There is absence or less numbered ganglions in myenteric plexus. - ...
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In TOF hea will be normal in size. In ebstein anomaly first hea sound is split. Ref : Ghai essential of pediatrics, eighth edition, p.no:424
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Answer is B (IgM fixes complements): IgM and IgG .fix complement the classical pathway
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Chemoprophylaxis against Diphtheria:- * Close contacts are subjected to throat cultures to establish their carrier status. * Irrespective of culture results, all contacts are staed on chemoprophylaxis. Chemoprophylaxis Drug options: * Oral Erythromycin (1g/day for adults; children - 40mg/Kg/day): once a day for 7-10 da...
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Surveillance after treatment Clinical surveillance of cases after completion of treatment is an important part of the current recommendations for multidrug therapy. It is essential for the assurance of the long-term success of treatment and for the early detection of any relapses. The recommendations are - i) Paucib...
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Bishop Koop Operation  Done for meconium ileus. It is resection of most dilated segment with an end to side anastomosis of colon to ileum. The distal eleal opening is formed into ileostomy.
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Ans. A. Diazepam is helpful in reducingExplanationDiazepam is used to treat alcohol withdrawal tremors.In Parkinsonism slow resting tremors 3-6 Hz are seen. Treatment of parkinsonism is with:Anticholinergic drugs like trihexiphenidyl, Benztropine, amantadine and selegilineDopamine agonist like Pramipexole, Ropinirole, ...
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Glycogen is the reserve carbohydrate in animals. It is stored in liver and muscles.The phosphorylated enzyme is less sensitive to allosteric inhibitors. Thus even if cellular ATP and glucose-6-phosphate are high, Phosphorylase will be active. The glucose-1-phosphate produced from glycogen in the liver may be conveed to...
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Phospholipids are :Glycerophospholipids (glycerol containing) :- Phosphatidylcholine (lecithin), phosphatidylethanolamine (cephaline), phosphatidylserine, phosphatidylinositol, plasmalogens, lysophospholipids, cardiolipin.Sphingophospholipids (sphingosine containing) :- Sphingomyeline
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Roth spots Round retinal hemorrhages with white centers Seen in : Infective endocarditis SLE Serum sickness Polyaeritis nodosa Severe anemia Leukemia Prolonged anesthesia
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*The functional residual capacity and residual volume are decreased due to elevated diaphragm. GFR increases by 50% Cardiac output increases by 40% Hemoglobin and hematocrit decreases. Reference : William's Textbook of Obstetrics 24th edition page 62
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Ans. is 'a' i.e., Edinger westphal nucleusPupillary light reflex (Light reflex)* Pupillary light reflex refers to constriction of pupil in response to light. When a sudden light is thrown into the eye, the pupil of that eye constricts (direct light reflex). The pupil of other eye also constricts (Consensual or indirect...
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Ans. is 'd' i.e., All of the above Pubey is triggered by a release of gonadotropins (FSH and LH) from pituitary gland. These hormones act as signals to the gonads (testes/ovaries) that trigger the production of - i) Estrogen, progesterone and some testosterone in women. ii) Testosterone in men. In both males and female...
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Ans. Retinoblastoma
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Pheochromocytoma must be operated on first. These tumors are generally (>50%) bilateral. Total thyroidectomy is the treatment of choice for patients with MTC because of the high incidence of multicentricity, the more aggressive course, and the fact that 131I therapy usually is not effective. Central compartment nodes f...
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Atractyloside inhibits oxidative phosphorylation by inhibiting the transpoer of ADP into and ATP out of the mitochondrion. Reference: Harper; 30th edition; Page no: 132
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Ans. is b i.e. Is due to increase in blood flow through the dilated uterine vessels Uterine souffle is a soft blowing systolic murmur The sound is synchronous with maternal pulse It is due to increase in blood flow through the dilated uterine vessels Heard low down at the sides of the uterus, best on the left side It c...
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* Narcoanalysis is a test carried out on a patient or suspect when he/she, after administering truth serum, comes in a sleep like state, and his/her repressed feelings are released. * Truth serum are drugs used in narcoanalysis. Two most common drugs used in narcoanalysis are Sodium amytal, which is also known as amoba...
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The typical findings in acquired or inherited forms of classic distal A (type 1 A) include hypokalemia, non-AG metabolic acidosis, low urinary NH4+ excretion (positive UAG, low urine ), and inappropriately high urine pH (pH > 5.5). Most patients have hypocitraturia and hypercalciuria, so nephrolithiasis, nephrocalcinos...
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D i.e. LSD
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Furious Rabies generally manifests as headache, fever, irritability, restlessness and anxiety. It is associated with dilated pupils, lacrimation, salivation and perspiration. Muscle pains, salivation and vomitting may follow. A few days following exposure the patient may experience a stage of excitement or muscle spasm...
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RV = Total lung capacity minus vital capacity. RV is volume remained in lungs after forceful expiration.
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The gene for CRP is on chromosome 1. CRP is an abnormal protein which appear in blood in response to inflammatory cytokines such as IL 6. It is one of the most sensitive acute pahse reactant. It is elevated following severe trauma, bacterial infections, inflammation, surgery or neoplastic proliferation.
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Hb Ba: Most severe form of Alpha thalassemia As Hb Ba's consists of 4-gamma chains - have very high oxygen affinity Thus, it cannot release oxygen to fetal tissues.
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Topical steroid
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A panel discussion is designed to provide an oppounity for a group to hear several people knowledgeable about a specific issue or topic present information and discuss personal views. A panel discussion may help the audience fuher clarify and evaluate their positions regarding specific issues or topics being discussed ...
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REF : ANANTHANARYANA MICROBIOLOGY
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Isozymes/Isoenzymes are different forms of same enzyme,catalyzing same reaction in same species, Example:- There are five isozymes of Lactate Dehydrogenase (LDH-1 to LDH-5), All conve Pyruvate to Lactate. Same for Isoenzymes Reaction Species Different for Isoenzymes Structure (subunits) Km, Vmax Electrophoretic mobilit...
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The trapezoid body is located in the caudal pons, or more specifically the pontine tegmentum. The trapezoid body is pa of the auditory pathway where some of the axons coming from the cochlear nucleus decussate, or cross over to the other side before traveling on to the superior olivary nucleus. This is believed to help...
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Leprosy
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Epigenetic changes include:- alterations of chromatin structure mediated by methylation of cytosine residues in CpG dinucleotides modification of histones by acetylation or methylation. The transcriptional regulatory regions of active genes often contain a high frequency of CpG dinucleotides (referred to as CpG islands...
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The synopsis of forensic medicine & toxicology ; Dr k.s.narayan reddy ;28th edition ; Pg .no. 110 Blunt force on areas where the skin is close to bone ,and the subcutaneous tissues are scanty ,may produce a wound that looks like a incised wound . In the options given forehead is the most applicable answer as it fulfils...
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Palliative procedures like palliative paial gastrectomy, anterior gastrojejunostomy, Devine's exclusion procedure, luminal stenting in proximal inoperable growths, chemotherapy are used in inoperable cases. * In early carcinoma proper lymph nodal clearance is impoant. Antrectomy is also called as hemi-gastrectomy. Remo...
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Ans. is 'b' i.e., Median nerve Anterior interosseous nerve is a branch of median nerve. Anterior interosseous aery is a branch of ulnar aery.
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Zinc deficiency is characterized by growth retardation, loss of appetite, and impaired immune function. In more severe cases, zinc deficiency causes hair loss, diarrhea, delayed sexual maturation, impotence, hypogonadism in males, and eye and skin lesions. Reference: GHAI Essential pediatrics, 8th edition
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Osteosarcoma - New bone is laid down along the blood vessels within the tumor growing centrifugally giving rise to a 'Sun -ray appearance' on x -ray. Chondrosarcoma- "Speckled" calcification on x-ray Ewings sarcoma - Second most common malignant. Classic x-ray appearance is the "onion skin"
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*Rivastigmine is used in Alzheimer's disease. It inhibits acetylcholinesterase and increases the level of ACh. *Tricyclic antidepressants have strong anticholinergic actions.Therefore,these can reduce the efficacy of rivastigmine. Depression is commonly seen in patients with Alzheimer's disease. The anti-depressants th...
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TRANSPOSABLE GENETIC ELEMENTS Ceain structurally and genetically discrete segments of DNA have been identified that have the ability to move around in a cut and paste manner between chromosomal and extrachromosomal DNA molecule within the cells. These DNA molecules are called transposons(jumping genes) A transposon is ...
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